Adelaide Medical School
Faculty of Health and Medical Sciences
Alexandra McCarron is a PhD candidate from the Adelaide Medical School, University of Adelaide. In 2015, she joined the Cystic Fibrosis Airway Research Group (CFARG) to undertake an honours project and continued on with the group, commencing a PhD in 2016.
Alexandra’s PhD research is in the field of airway gene therapy, a therapeutic approach that has potential to treat or prevent cystic fibrosis lung disease by correcting the underlying genetic defect. Her research includes developing novel bioprocessing methods for large-scale gene vector production, characterising and employing cystic fibrosis animal models for preclinical trialling of airway gene therapy, and investigating airway stem cell targeting methods for achieving a sustained therapeutic effect.
Year Citation 2020 Morgan, K. S., Parsons, D., Cmielewski, P., McCarron, A., Gradl, R., Farrow, N., . . . Donnelley, M. (2020). Methods for dynamic synchrotron X-ray respiratory imaging in live animals. Journal of synchrotron radiation, 27(Pt 1), 164-175.
2020 McCarron, A., Cmielewski, P., Reyne, N., McIntyre, C., Finnie, J., Craig, F., . . . Donnelley, M. (2020). Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing.. The American journal of pathology.
2019 McCarron, A., Donnelley, M., Cmielewski, P., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. MOLECULAR THERAPY, 27(4), 209. 2019 Gardner, M., McCarron, A., Morgan, K., Parsons, D., & Donnelley, M. (2019). Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study. Scientific Reports, 9(1), 10 pages.
2019 McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. Human Gene Therapy Methods, 30(3), 93-101.
DOI Scopus2 WoS1 Europe PMC1
2018 McCarron, A., Donnelley, M., & Parsons, D. (2018). Airway disease phenotypes in animal models of cystic fibrosis. Respiratory Research, 19(1), 54-1-54-12.
DOI Scopus10 WoS10 Europe PMC6
2016 McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2016). Challenges of up-scaling lentivirus production and processing. Journal of Biotechnology, 240, 23-30.
DOI Scopus28 WoS21 Europe PMC15
Year Citation 2019 Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers.
2019 Li, J., Quirk, B., Delhove, J., Kirk, R., Mc Carron, A., Cmielewski, P., . . . McLaughlin, R. (2019). Imaging Genetically-Modified Cells with a Miniaturised Multimodal Optical Coherence Tomography + Fluorescence Probe. In 2019 IEEE Photonics Conference, IPC 2019 - Proceedings (pp. 1-2). online: IEEE.
2020 - 2021 Women's and Children's Hospital Foundation "Airway gene correction in neonatal cystic fibrosis rats", $100,000
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