Alexandra Mc Carron

Alexandra Mc Carron

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr McCarron is a post-doctoral researcher with the Cystic Fibrosis Airway Research Group (CFARG) and is based in the Department of Respiratory Medicine at the Women's and Children's Hospital. 

My research

My research is in the area of airway gene therapy, a therapeutic approach that has potential to treat or prevent cystic fibrosis lung disease by correcting the underlying genetic defect. My work includes the production of lentiviral gene vectors, characterising and employing cystic fibrosis animal models for trialing of airway gene therapy, and investigating novel methods for enhancing the efficacy of airway gene transfer. 

Student projects

I have projects available for Summer Research Scholarship students, Bachelor of Health and Medical Sciences (BHMS) Third Year Research Placement students, and Honours students. The skills developed during these projects can include: rodent handling, airway gene delivery techniques, tissue collection, histology, immunohistochemistry, cell culture, gene vector production, data collection, analysis and interpretation.

  • Education

    Date Institution name Country Title
    2021 The University of Adelaide Australia PhD in Medicine
    2015 The University of Adelaide Australia Bachelor of Health Science (Honours)
    2014 The University of Adelaide Australia Bachelor of Science (Animal Science)
  • Journals

    Year Citation
    2021 Mc Carron, A., Parsons, D., & Donnelley, M. (2021). Animal and cell culture models for cystic fibrosis: which model is right for your application?. American Journal of Pathology, 191(2), 228-242.
    DOI Scopus3 WoS5 Europe PMC3
    2021 Carpentieri, C., Farrow, N., Cmielewski, P., Rout-Pitt, N., Mccarron, A., Knight, E., . . . Donnelley, M. (2021). The Effects of Conditioning and Lentiviral Vector Pseudotype on Short- A nd Long-Term Airway Reporter Gene Expression in Mice. Human Gene Therapy, 32(15-16), 817-827.
    DOI Scopus1 WoS1
    2021 McCarron, A., Farrow, N., Cmielewski, P., Knight, E., Donnelley, M., & Parsons, D. (2021). Breaching the delivery barrier: Chemical and physical airway epithelium disruption strategies for enhancing lentiviral-mediated gene therapy. Frontiers in Pharmacology, 12, 669635-1-669635-11.
    2021 Reyne, N., Cmielewski, P., McCarron, A., Delhove, J., Parsons, D., & Donnelley, M. (2021). Single-dose lentiviral mediated gene therapy recovers CFTR function in cystic fibrosis knockout rats. Frontiers in Pharmacology, 12, 682299-1-682299-8.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Gardner, M., Parsons, D., Morgan, K. S., McCarron, A., Cmielewski, P., Gradl, R., & Donnelley, M. (2020). Towards automated <i>in vivo</i> tracheal mucociliary transport measurement: detecting and tracking particle movement in synchrotron phase-contrast X-ray images. Physics in Medicine and Biology, 65(14), 145012-1-145012-17.
    2020 McCarron, A., Cmielewski, P., Reyne, N., McIntyre, C., Finnie, J., Craig, F., . . . Donnelley, M. (2020). Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing. The American Journal of Pathology, 190(5), 977-993.
    DOI Scopus10 WoS11 Europe PMC9
    2020 Morgan, K. S., Parsons, D., Cmielewski, P., McCarron, A., Gradl, R., Farrow, N., . . . Donnelley, M. (2020). Methods for dynamic synchrotron X-ray respiratory imaging in live animals. Journal of synchrotron radiation, 27(Pt 1), 164-175.
    DOI Scopus8 WoS7 Europe PMC4
    2019 McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2019). Transient lentiviral vector production using a packed-bed bioreactor system. Human Gene Therapy Methods, 30(3), 93-101.
    DOI Scopus10 WoS9 Europe PMC5
    2019 Gardner, M. T., McCarron, A., Morgan, K., Parsons, D., & Donnelley, M. (2019). Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study. Scientific Reports, 9(1), 10983-1-10983-10.
    DOI Scopus2
    2018 Rout-Pitt, N., McCarron, A., McIntyre, C., Parsons, D., & Donnelley, M. (2018). Large-scale production of lentiviral vectors using multilayer cell factories. Journal of Biological Methods, 5(2), e90-1-e90-9.
    DOI Europe PMC7
    2018 McCarron, A., Donnelley, M., & Parsons, D. (2018). Airway disease phenotypes in animal models of cystic fibrosis. Respiratory Research, 19(1), 54-1-54-12.
    DOI Scopus27 WoS30 Europe PMC23
    2017 McCarron, A., Donnelley, M., & Parsons, D. (2017). Scale-up of lentiviral vectors for gene therapy: advances and challenges. Cell and Gene Therapy Insights, 3(9), 719-729.
    2016 McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2016). Challenges of up-scaling lentivirus production and processing. Journal of Biotechnology, 240, 23-30.
    DOI Scopus58 WoS55 Europe PMC31
  • Conference Papers

    Year Citation
    2019 Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers.
    DOI Scopus1
    2019 Li, J., Quirk, B., Delhove, J., Kirk, R., Mc Carron, A., Cmielewski, P., . . . McLaughlin, R. (2019). Imaging genetically-modified cells with a miniaturised multimodal optical coherence tomography + fluorescence probem. In Proceedings of the 2019 IEEE Photonics Conference (IPC) (pp. 1-2). Piscataway, NJ: IEEE.
    2019 McCarron, A., Donnelley, M., Cmielewski, P., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. In MOLECULAR THERAPY Vol. 27 (pp. 209). Washington, DC: CELL PRESS.

2020 - 2021 Women's and Children's Hospital Foundation "Airway gene correction in neonatal cystic fibrosis rats", $100,000

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