Dr Alexandra Mc Carron

NHMRC Grant-Funded Researcher A

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

My Research
Career
Publications
Grants and Funding
Supervision
Contact

I am a postdoctoral researcher with the Cystic Fibrosis Airway Research Group (CFARG), based in the Department of Respiratory Medicine at the Women's and Children's Hospital.

My research

My research is in the area of airway gene therapy, a therapeutic approach that has potential to treat or prevent cystic fibrosis lung disease by correcting the underlying genetic defect. My work includes the production of lentiviral gene vectors, characterising and employing cystic fibrosis animal models for trialing of airway gene therapy, and investigating novel methods for enhancing the efficacy of airway gene transfer.

Student projects

I have projects available for Summer Research Scholarship students, Bachelor of Health and Medical Sciences (BHMS) Third Year Research Placement students, and Honours students. The skills developed during these projects can include: rodent handling, airway gene delivery techniques, tissue collection, histology, immunohistochemistry, cell culture, gene vector production, data collection, analysis and interpretation.

Education

Date	Institution name	Country	Title
2021	The University of Adelaide	Australia	PhD in Medicine
2015	The University of Adelaide	Australia	Bachelor of Health Science (Honours)
2014	The University of Adelaide	Australia	Bachelor of Science (Animal Science)

Journals

Year	Citation
2023	McCarron, A., Cmielewski, P., Drysdale, V., Parsons, D., & Donnelley, M. (2023). Effective viral-mediated lung gene therapy: is airway surface preparation necessary?. Gene Therapy, 30(6), 469-477. DOI Scopus6 WoS6 Europe PMC3
2023	Reyne, N., McCarron, A., Cmielewski, P., Parsons, D., & Donnelley, M. (2023). To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis. FRONTIERS IN PHYSIOLOGY, 14, 13 pages. DOI Scopus1
2023	Shrestha, N., Rout-Pitt, N., McCarron, A., Jackson, C. A., Bulmer, A. C., McAinch, A. J., . . . Hryciw, D. H. (2023). Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis. International Journal of Molecular Sciences, 24(8), 7194-1-7194-10. DOI
2023	Donnelley, M., Cmielewski, P., Knight, E., Carpentieri, C., McCarron, A., Rout-Pitt, N., . . . Farrow, N. (2023). Repeat or single-dose lentiviral vector administration to mouse lungs? It’s all about the timing. Gene Therapy, 30(9), 1-8. DOI
2023	McCarron, A. (2023). Slow and steady wins the race: Optimizing lentiviral vector production for efficient clinical-scale manufacturing. Molecular Therapy - Methods and Clinical Development, 30, 484-485. DOI
2022	Donnelley, M., Cmielewski, P., Morgan, K., Delhove, J., Reyne, N., McCarron, A., . . . Parsons, D. (2022). Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging. Scientific Reports, 12(1), 9000-1-9000-14. DOI
2022	Drysdale, V., Cmielewski, P., Donnelley, M., Reyne, N., Parsons, D., & Mccarron, A. (2022). Comparison of Physical Perturbation Devices for Enhancing Lentiviral Vector-Mediated Gene Transfer to the Airway Epithelium. Human Gene Therapy, 33(19-20), 1062-1072. DOI
2022	Shrestha, N., McCarron, A., Rout-Pitt, N., Donnelley, M., Parsons, D. W., & Hryciw, D. H. (2022). Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex. Nutrients, 14(21), 4666. DOI Scopus1 WoS1 Europe PMC1
2021	Mc Carron, A., Parsons, D., & Donnelley, M. (2021). Animal and cell culture models for cystic fibrosis: which model is right for your application?. American Journal of Pathology, 191(2), 228-242. DOI Scopus27 WoS23 Europe PMC20
2021	Carpentieri, C. L., Farrow, N. R., Cmielewski, P., Rout-Pitt, N., Mc Carron, A., Knight, E., . . . Donnelley, M. (2021). The effects of conditioning and lentiviral vector pseudotype on short- and long-term airway reporter gene expression in mice.. Human gene therapy, 32(15-16), 817-827. DOI Scopus4 WoS4 Europe PMC3
2021	Mc Carron, A., Farrow, N., Cmielewski, P., Knight, E., Donnelley, M., & Parsons, D. (2021). Breaching the delivery barrier: Chemical and physical airway epithelium disruption strategies for enhancing lentiviral-mediated gene therapy. Frontiers in Pharmacology, 12, 669635-1-669635-11. DOI Scopus5 WoS5 Europe PMC3
2021	Reyne, N., Cmielewski, P., Mc Carron, A., Delhove, J., Parsons, D., & Donnelley, M. (2021). Single-dose lentiviral mediated gene therapy recovers CFTR function in cystic fibrosis knockout rats. Frontiers in Pharmacology, 12, 682299-1-682299-8. DOI Scopus7 WoS6 Europe PMC5
2020	Gardner, M., Parsons, D., Morgan, K. S., McCarron, A., Cmielewski, P., Gradl, R., & Donnelley, M. (2020). Towards automated <i>in vivo</i> tracheal mucociliary transport measurement: detecting and tracking particle movement in synchrotron phase-contrast X-ray images. Physics in Medicine and Biology, 65(14), 145012-1-145012-17. DOI Scopus4 Europe PMC2
2020	McCarron, A., Cmielewski, P., Reyne, N., McIntyre, C., Finnie, J., Craig, F., . . . Donnelley, M. (2020). Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing. The American Journal of Pathology, 190(5), 977-993. DOI Scopus22 WoS20 Europe PMC16
2020	Morgan, K. S., Parsons, D., Cmielewski, P., McCarron, A., Gradl, R., Farrow, N., . . . Donnelley, M. (2020). Methods for dynamic synchrotron X-ray respiratory imaging in live animals. Journal of synchrotron radiation, 27(Pt 1), 164-175. DOI Scopus17 WoS16 Europe PMC7
2019	McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2019). Transient lentiviral vector production using a packed-bed bioreactor system. Human Gene Therapy Methods, 30(3), 93-101. DOI Scopus19 WoS17 Europe PMC12
2019	Gardner, M. T., McCarron, A., Morgan, K., Parsons, D., & Donnelley, M. (2019). Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study. Scientific Reports, 9(1), 10983-1-10983-10. DOI Scopus5 WoS2 Europe PMC1
2018	Rout-Pitt, N., McCarron, A., McIntyre, C., Parsons, D., & Donnelley, M. (2018). Large-scale production of lentiviral vectors using multilayer cell factories. Journal of Biological Methods, 5(2), e90-1-e90-9. DOI Europe PMC12
2018	McCarron, A., Donnelley, M., & Parsons, D. (2018). Airway disease phenotypes in animal models of cystic fibrosis. Respiratory Research, 19(1), 54-1-54-12. DOI Scopus50 WoS48 Europe PMC41
2017	McCarron, A., Donnelley, M., & Parsons, D. (2017). Scale-up of lentiviral vectors for gene therapy: advances and challenges. Cell and Gene Therapy Insights, 3(9), 719-729. DOI
2016	McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2016). Challenges of up-scaling lentivirus production and processing. Journal of Biotechnology, 240, 23-30. DOI Scopus74 WoS63 Europe PMC44

Conference Papers

Year	Citation
2019	Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers. DOI Scopus1
2019	Li, J., Quirk, B. C., Delhove, J., Kirk, R., Mc Carron, A., Cmielewski, P., . . . McLaughlin, R. A. (2019). Imaging genetically-modified cells with a miniaturised multimodal optical coherence tomography + fluorescence probem. In Proceedings of the 2019 IEEE Photonics Conference (IPC) (pp. 1-2). Piscataway, NJ: IEEE. DOI
2019	McCarron, A., Donnelley, M., Cmielewski, P., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. In MOLECULAR THERAPY Vol. 27 (pp. 209). Washington, DC: CELL PRESS.

2023- 2024 Channel 7 Children's Research Foundation "Does the presence of lung infection impact the efficacy of cystic fibrosis airway gene therapy?", $40,060 (Chief investigator)

2020 - 2021 Women's and Children's Hospital Foundation "Airway gene correction in neonatal cystic fibrosis rats", $100,000 (Chief investigator)

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2023	Co-Supervisor	Understanding and improving gene vector targeting with lentiviral magnetic nanoparticles	Doctor of Philosophy under a Jointly-awarded Degree Agreement with	Doctorate	Part Time	Ms Madison Michelle Davis
2021	Co-Supervisor	Improving the effectiveness of airway lentiviral gene therapy for cystic fibrosis	Doctor of Philosophy	Doctorate	Full Time	Mrs Nikki Reyne

Position: NHMRC Grant-Funded Researcher A
Phone: 0881619182
Email: alexandra.mccarron@adelaide.edu.au
Campus: North Terrace
Building: Women's and Children's Hospital, floor 6
Org Unit: Women's and Children's Health

Dr Alexandra Mc Carron

Education

Journals

Conference Papers

Current Higher Degree by Research Supervision (University of Adelaide)

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External Profiles