
David Haynes
School of Biomedicine
Faculty of Health and Medical Sciences
Professor David R Haynes is Deputy Head of the School of Medicine, University of Adelaide. He has published well over 100 publications in respected peer reviewed journals. Over the past two decades he has developed a respected international reputation in the fields of bone pathologies, biomaterials and inflammation.
Over the past decade he has been President and Secretary of the Australian and New Zealand Society of Orthopaedic Research (www.ANZORS.org.au). In these roles he has help organise more than 5 national and 3 international meetings.
Professor Haynes has been chief investigator on more than 17 successful major national and international grants (NH&MRC, European Union Framework 7 and ARC) grants since the early 1990’s as well as several commercially funded studies on pharmacological regulation of inflammatory cytokines, pathogenic bone loss and implant loosening. He also makes a significant contribution to the training of medical students (MBBS), Health Science students and Nursing students in the Faculty of Health and Medical Sciences.
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Appointments
Date Position Institution name 2015 - 2016 Professor & Deputy Head University of Adelaide 2013 - 2015 Head of the School of Medical Sciences University of Adelaide, Adelaide 2010 - 2015 Associate Professor University of Adelaide 2009 - 2013 Head of Anatomy and Pathology University of Adelaide, Adelaide 2006 - 2010 Senior Lecturer University of Adelaide 2000 - 2006 Lecturer University of Adelaide 1994 - 2000 Scientific Officer University of Adelaide 1982 - 1994 Technical Officer University of Adelaide 1978 - 1982 Research assistant/technical assistant University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2012 Award The Presidents Prize for Collaborative Research , Australian Arthritis Association. - Australia - 2012 Award Prof Malcolm Smith The Presidents Prize for Collaborative Research 2012 Australian Arthritis Association - - 2006 Award Awarded Subspeciallity Showcase ASM Hobart Australian Orthopaedic Association 2008. - Australia - -
Education
Date Institution name Country Title University of Adelaide Australia BSc University of Adelaide Australia BSc Hons University of Adelaide Australia PhD (Med) -
Research Interests
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Journals
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Books
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Book Chapters
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Conference Papers
Year Citation 2011 Dharmapatni, A., Fitzpatrick, D., Cantley, M. D., & Haynes, D. R. (2011). INCREASED SOFAT MRNA EXPRESSION DURING OSTEOCLAST DEVELOPMENT, EVIDENCE THAT SOFAT IS NOT ONLY ASSOCIATED WITH T CELLS. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD. 2011 Atkins, G. J., Vincent, C., Wijenayaka, A. R., Welldon, K. J., Haynes, D. R., Zheng, T. S., . . . Findlay, D. M. (2011). THE EFFECTS OF TWEAK AND TNF ON HUMAN OSTEOBLASTS: MAPK DEPENDENT INDUCTION OF SCLEROSTIN EXPRESSION. In D. Wallach, A. Kovalenko, & M. Feldman (Eds.), ADVANCES IN TNF FAMILY RESEARCH Vol. 691 (pp. 688). San Lorenzo del Escorial, SPAIN: SPRINGER-VERLAG BERLIN. 2011 Crotti, T. N., Zawawi, M. S., Dharmapatni, A. A., Cantley, M. D., & Haynes, D. R. (2011). INHIBITION OF ITAM ADAPTOR MOLECULES AND THEIR RECEPTORS BY INHIBITION OF CALCINEURIN-NFAT SIGNALLING DURING LATE STAGE HUMAN OSTEOCLAST DIFFERENTIATION. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD. 2011 Dharmapatni, A. A. S., Gillard, J. W., Rainsford, K. D., & Haynes, D. R. (2011). REGULATION OF HUMAN OSTEOCLAST ACTIVITY AND APOPTOSIS BY IAP INHIBITORS IN VITRO. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603-S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD. 2011 Cantley, M. D., Fairlie, D. P., Bartold, P., Marino, V., & Haynes, D. R. (2011). INHIBITING HISTONE DEACETYLASES EXPRESSED IN HUMAN PERIODONTAL TISSUES PREVENTS BONE LOSS IN AN ANIMAL MODEL OF PERIODONTAL DISEASE. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S613). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD. 2010 Haynes, D. R., Dharmapatni, K., Smith, M. D., Chen, D. Y., Holding, C. A., Weedon, H., & Upton, A. (2010). A ROLE FOR TNF-LIKE WEAK INDUCER OF APOPTOSIS (TWEAK) DERIVED FROM SYNOVIAL TISSUES AND CARTILAGE IN THE PATHOGENESIS OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S100). Brussels, BELGIUM: W B SAUNDERS CO LTD.
DOI2010 Cantley, M., Haynes, D. R., & Rainsford, K. D. (2010). EFFECTS OF RIBONUCLEINATE COMPONENTS OF OSTEOCHONDRIN<SUP>R</SUP> S OSTEOARTHRITIS THERAPY ON FORMATION AND ACTIVITY OF HUMAN OSTEOCLASTS <i>IN VITRO</i>. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S254-S255). Brussels, BELGIUM: W B SAUNDERS CO LTD.
DOI WoS12009 Wijenayaka, A. R., Vincent, C., Findlay, D. M., Welldon, K. J., Zheng, T. S., Haynes, D. R., . . . Atkins, G. J. (2009). The proinflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFa induce the mitogen activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. In BONE Vol. 44 (pp. S63). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI WoS12009 Welldon, K. J., Holding, C., Haynes, D. R., Howie, D. W., Findlay, D. M., & Atkins, G. J. (2009). Polyethylene particles activate pro-osteoclastogenic signalling pathways in human primary osteoblasts and osteocytes. In BONE Vol. 44 (pp. S127-S128). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI2009 Cantley, M. D., Fairlie, D. P., Bartold, M. P., Rainsford, K. D., & Haynes, D. R. (2009). Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro. In BONE Vol. 44 (pp. S133-S134). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI WoS12008 Atkins, G. J., Vincent, C., Wijenayaka, A. R., Welldon, K. J., Haynes, D. R., Zheng, T. S., . . . Findlay, D. M. (2008). The Proinflammatory Cytokine TWEAK Induces Sclerostin Expression in Human Immature Osteoblasts in a MAPK Dependent Fashion.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 23 (pp. S385). Montreal, CANADA: AMER SOC BONE & MINERAL RES. 2007 Atkins, G. J., Vincent, C., Welldon, K. J., Haynes, D. R., Holding, C., Zheng, T. S., . . . Findlay, D. M. (2007). TWEAK is a regulator of human osteoblast function. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S138). Honolulu, HI: AMER SOC BONE & MINERAL RES. 2006 Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., & Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. In Key Engineering Materials Vol. 309-311 I (pp. 709-712). Trans Tech Publications Ltd..
DOI Scopus32005 Dharmapatni, A. A. S. S. K., Findlay, D. M., Smith, M. D., Evdokiou, A., Chen, P., Screaton, G. R., . . . Haynes, D. R. (2005). Regulating the sensitivity of synovial fibroblasts to trail-induced apoptosis. In ANNALS OF THE RHEUMATIC DISEASES Vol. 64 (pp. 154). Vienna, AUSTRIA: BMJ PUBLISHING GROUP. 2004 Lucas, H., Zreiqat, H., Gross, K. A., Holding, C., Findlay, D. M., Wallwork, M., & Haynes, D. R. (2004). Osteoclast resorption of hydroxyapatite bone substitute materials in vitro. In Transactions - 7th World Biomaterials Congress (pp. 1309). 2004 Peters, K., Haynes, D. R., Crotti, T. N., Unger, R. E., & Kirkpatrick, C. J. (2004). Effects of wear particles from metallic implant materials on the pro-inflammatory state of endothelial cells in vitro. In Transactions - 7th World Biomaterials Congress (pp. 1150). 1999 Atkins, G. J., Loric, M., Crotti, T. N., Haynes, D. R., & Findlay, D. M. (1999). Osteoclast differentiation factors are expressed by both stromal and haematopoietic cells in human osteoclast formation. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 547-551). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD. 1999 Crotti, T. N., Potter, A. E., Atkins, G. J., Findlay, D. M., Howie, D. W., & Haynes, D. R. (1999). Osteoclast differentiation and development is regulated by mediators released in response to prosthetic particles. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 542-546). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD. -
Conference Items
Year Citation 2016 Crotti, T. N., Coleman, R., Dharmapatni, A. A., Weedon, H., Haynes, D. R., Smith, M. D., & Wechalekar, M. D. (2016). EXPRESSION OF OSCAR IN THE SYNOVIUM OF EARLY RA PATIENTS. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP.
DOI2014 Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2014). THE X-LINKED INHIBITORY OF APOPTOSIS PROTEIN INHIBITOR, EMBELIN SUPPRESSES INFLAMMATION AND BONE EROSION IN COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA) MICE. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL. 2013 Dharmapatni, A., Coleman, R., Lorimer, M., Zannettino, A., Weedon, H., Wechalekar, M., . . . Crotti, T. (2013). Relationship between Soluble OSCAR and Disease Activity: A 12 Month Study of Newly Diagnosed RA Patients. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Baltimore, MD: WILEY-BLACKWELL. 1998 Irani, D. M., Pierce, A. M., Gully, N. J., Haynes, D. R., & Wilson, D. F. (1998). <i>Eikenella corrodens</i> surface associated material stimulates osteolytic cytokines.. Poster session presented at the meeting of JOURNAL OF DENTAL RESEARCH. AMER ASSOC DENTAL RESEARCH. 1998 Irani, D. M., Pierce, A. M., Haynes, D. R., Gully, N. J., & Wilson, D. F. (1998). <i>Eikenella corrodens</i> surface associated material stimulates osteolytic cytokines.. Poster session presented at the meeting of JOURNAL OF DENTAL RESEARCH. SAGE PUBLICATIONS INC.
Date | Project/ No. | Investigators | Funding Body | Amount |
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1991-1994 | Arthritis : Mechanisms of initiation and their modulation by drugs. / #31264 |
Vernon-Roberts B, Whitehouse MW, Haynes DR |
NHMRC | $238622 |
1994 | Wear particle induced bone resorption causing joint replacement loosening. / #31965 |
Howie DW, Vernon-Roberts B, Haynes DR |
NHMRC | $133454 |
1994 | Arthritis: Manipulating endogenous mediators to optimise treatment. / #32432 |
Vernon-Roberts B, Whitehouse MW, Haynes DR |
NHMRC | $60,152 |
1996-1998 | Cell biology and drug control of loosening of joint prostheses. / #34313 |
Vernon-Roberts B, Howie DW, Haynes DR, Graves SE |
NHMRC | $161100 |
1998-2000 | Requirements for human osteoclast generation. / #35252 |
Findlay DM, Haynes DR, Howie DW |
NHMRC | $166,000 |
2000-2002 | Cell regulation of periprosthetic bone loss. / #104818* |
Haynes DR, Findlay DM, Vernon-Roberts B, Howie DW |
NHMRC | $318,630 |
2001-2003 | Requirements for human osteoclast generation. / #157984 |
Findlay DM, Atkins GJ, Haynes DR, Zannetino A |
NHMRC | $273,000 |
2003-2005 | Mechanisms of periprosthetic bone loss. / #250344 |
Findlay DM, Haynes DR, Howie DW, McGee MA |
NHMRC | $315,000 |
2005-2007 | Improving orthopaedic/dental devices by surface chemical modification / #DP0556403 |
Zreiqat H, Swain MV, Haynes DR, Anderson G |
ARC | $555,000 |
2004-2006 | Regulation of bone resorption in periodontal disease. / #299028 |
Haynes DR, Bartold PM, Findlay DM, Gully NJ |
NHMRC |
$254,750 |
2004-2006 | Inducing normal bone remodelling at the medical device/ bone interface. / #300487 |
Zreiqat H , Haynes DR |
NHMRC | $468,250 |
2006 -2008 | Impaired bone remodelling leads to failure of orthopaedic prostheses. / #399168 |
Findlay DM, Haynes DR, Howie DW, Atkins GJ, Crotti TN |
NHMRC | $515,917 |
2007-2009 | The role of TNF family members TWEAK and TNF-alpha in bone remodelling./ #453605 |
Atkins GJ, Findlay DM, Haynes DR, Zheng TS, Zannetino A |
NHMRC | $544,500 |
2007-2009 | Regulation of Osteoclasts in Bone Pathologies./ #453568 |
Haynes DR, Bartold PM, Smith MD, Rainsford KD |
NHMRC | $566,947 |
2009-2012 | Regulation of key pathways causing peri-implant bone loss./ #565361 |
Haynes DR, Findlay DM, Atkins GA, Howie DW, Crotti TN |
NHMRC | $536,613 |
2011-2013 | Sclerostin effects on bone mineralisation and catabolism. / #1004871 |
GJ Atkins, Findlay DM, Haynes DR |
NHMRC | $536,653 |
2012-2014 | Periodontal disease and rheumatoid arthritis / #1023747 |
Bartold PM , Haynes DR, Smith MD, Proudman S |
NHMRC | $536,128 |
2013-2015 | Particle induced osteolysis and osteocytes / #1041456 |
GJ Atkins, Haynes DR, Findlay DM |
NHMRC | $449,619 |
2014-2016 | HDAC 1 and 5 in periodontitis / #1057853 |
Haynes DR, Bartold PM , Cantley MD |
NHMRC | $518,901 |
2014-2017 | An international network on new strategies for processing calcium phosphates. |
Riga Technical University, University of Riga, Universite de Technologie de Belfort Montbeliard, University College London, Ludwig Boltzmann Gesellschaft, University de Limoges |
European Community Seventh Framework Programme Grant |
Teaching
Course coordinator of the compulsory second year course Biology of Disease in the Bachelor of Health Sciences program.
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2021 Co-Supervisor Studies on the Functions of Latent Transforming Growth Factor Beta (TGF-Beta) Binding Protein-2 (LTBP-2) in the Regulation of TGF-Beta 1 and Fibrosis Progression Doctor of Philosophy Doctorate Full Time Mr Yike You 2015 - 2020 Principal Supervisor Osteochondroreticular Stem Cell Therapy for Osteoarthritis: The right cells for the job Doctor of Philosophy Doctorate Full Time Miss Jia Ng 2014 - 2018 Principal Supervisor Epigenetic Regulation of Cells Involved in Periodontal Bone Destruction Through Targeted Histone Deacetylase Inhibition Doctor of Philosophy Doctorate Full Time Kent Algate 2012 - 2016 Co-Supervisor Function of Latent Transforming Growth Factor-B Binding Protein-2 (LTBP-2) in Elastinogenesis and Modulation of Growth Factor Storage, Expression and Activity in Normal and Fibrotic Tissues Doctor of Philosophy Doctorate Full Time Mr Mohamed Arshad Mohamed Sideek 2011 - 2015 Principal Supervisor Targeting NF-kappaB and NFATc1 signalling to inhibit bone resorption in peri-prosthetic osteolysis Doctor of Philosophy Doctorate Full Time Mr Muhamad Syahrul Fitri Zawawi 2010 - 2013 Principal Supervisor Targeting Histone Deacetylases to Suppress Bone Loss in Similar Chronic Inflammatory Diseases, Periodontitis and Rheumatoid Arthritis. Doctor of Philosophy Doctorate Full Time Dr Melissa Cantley 2008 - 2014 Principal Supervisor Osteoclast-associated Intracellular ITAM Signalling Molecules in Human Peri-implant Osteolysis and Rheumatoid Arthritis Doctor of Philosophy Doctorate Full Time Mr Ekram Alias 2003 - 2007 Principal Supervisor Trail Mediated Apoptosis in Arthritis Doctor of Philosophy Doctorate Full Time Ms Anak Dharmapatni 1999 - 2002 Principal Supervisor MEDIATORS OF LOCALISED PATHOLOGICAL BONE LOSS Doctor of Philosophy Doctorate Full Time APrf Tania Crotti 1997 - 2003 Principal Supervisor IMMUNOGENETIC DETERMINANTS OF CHRONIC Q FEVER Doctor of Philosophy Doctorate Full Time Dr Karla Helbig
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Committee Memberships
Date Role Committee Institution Country 2016 - ongoing Member International Combined Orthopaedic Societies for the Scientific Meeting in Xian - - 2007 - 2013 Member Combined Orthopaedic Research Societies (CORS) - - -
Memberships
Date Role Membership Country 2006 - 2009 President Australian New Zealand Orthopaedic Research Society Australia 2003 - 2006 Secretary Australian New Zealand Orthopaedic Research Society Australia 1999 - 2016 Member Australian New Zealand Bone and Mineral Society Australia -
Consulting/Advisories
Date Institution Department Organisation Type Country 2013 - 2016 Advisory Board of the Bone Foundation - - - -
Editorial Boards
Date Role Editorial Board Name Institution Country 2007 - ongoing Associate Editor Inflammopharmacology - - -
Offices Held
Date Office Name Institution Country 2006 - 2013 Australian representative and committee member of The International Orthopaedic Research Societies - - 2006 - 2009 President of the Australian and New Zealand Society of Orthopaedic Research - Australia 2003 - 2006 Secretary (2003-6) of the Australian and New Zealand Society of Orthopaedic Research (www.ANZORS.org.au) - Australia
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