David Haynes

Research Interests

Arthritis & Rheumatology Biomaterials Orthopaedics Pathology Periodontics Musculoskeletal Health Oral Health Immunology and Infection Innovative Therapeutics

EPrf David Haynes

School of Pharmacy and Biomedical Science

College of Health

Professor David R Haynes is Deputy Head of the School of Medicine, University of Adelaide. He has published well over 100 publications in respected peer reviewed journals. Over the past two decades he has developed a respected international reputation in the fields of bone pathologies, biomaterials and inflammation. Over the past decade he has been President and Secretary of the Australian and New Zealand Society of Orthopaedic Research (www.ANZORS.org.au). In these roles he has help organise more than 5 national and 3 international meetings. Professor Haynes has been chief investigator on more than 17 successful major national and international grants (NH&MRC, European Union Framework 7 and ARC) grants since the early 1990’s as well as several commercially funded studies on pharmacological regulation of inflammatory cytokines, pathogenic bone loss and implant loosening. He also makes a significant contribution to the training of medical students (MBBS), Health Science students and Nursing students in the Faculty of Health and Medical Sciences.

Date Position Institution name
2015 - 2016 Professor & Deputy Head University of Adelaide
2013 - 2015 Head of the School of Medical Sciences University of Adelaide, Adelaide
2010 - 2015 Associate Professor University of Adelaide
2009 - 2013 Head of Anatomy and Pathology University of Adelaide, Adelaide
2006 - 2010 Senior Lecturer University of Adelaide
2000 - 2006 Lecturer University of Adelaide
1994 - 2000 Scientific Officer University of Adelaide
1982 - 1994 Technical Officer University of Adelaide
1978 - 1982 Research assistant/technical assistant University of Adelaide

Date Type Title Institution Name Country Amount
2012 Award The Presidents Prize for Collaborative Research , Australian Arthritis Association. - Australia -
2012 Award Prof Malcolm Smith The Presidents Prize for Collaborative Research 2012 Australian Arthritis Association - -
2006 Award Awarded Subspeciallity Showcase ASM Hobart Australian Orthopaedic Association 2008. - Australia -

Date Institution name Country Title
University of Adelaide Australia BSc
University of Adelaide Australia BSc Hons
University of Adelaide Australia PhD (Med)

Year Citation
2023 Ng, J. Q., Jafarov, T. H., Little, C. B., Wang, T., Ali, A. M., Ma, Y., . . . Mukherjee, S. (2023). Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Nature Communications, 14(1), 6909-1-6909-14.
DOI Scopus28 WoS26 Europe PMC26
2020 Algate, K., Haynes, D., Fitzsimmons, T., Romeo, O., Wagner, F., Holson, E., . . . Cantley, M. (2020). Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. Journal of Cellular Biochemistry, 121(1), 244-258.
DOI Scopus23 WoS23 Europe PMC20
2019 Bartold, M., Gronthos, S., Haynes, D., & Ivanovski, S. (2019). Mesenchymal stem cells and biologic factors leading to bone formation. Journal of Clinical Periodontology, 46(S21), 12-32.
DOI Scopus57 WoS52 Europe PMC46
2019 Ormsby, R. T., Solomon, L. B., Yang, D., Crotti, T. N., Haynes, D. R., Findlay, D. M., & Atkins, G. J. (2019). Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways. Acta Biomaterialia, 87, 296-306.
DOI Scopus55 WoS46 Europe PMC39
2017 Cantley, M. D., Zannettino, A. C. W., Bartold, P. M., Fairlie, D. P., & Haynes, D. R. (2017). Histone deacetylases (HDAC) in physiological and pathological bone remodelling. Bone, 95, 162-174.
DOI Scopus47 WoS40 Europe PMC39
2017 Cantley, M., Rainsford, K., & Haynes, D. (2017). Yeast RNA extract suppresses human osteoclast resorption in vitro. Inflammopharmacology, 25(5), 571-576.
DOI
2016 Saad, S., Dharmapatni, A., Crotti, T., Cantley, M., Algate, K., Findlay, D., . . . Haynes, D. (2016). Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss. Acta Biomaterialia, 30, 311-318.
DOI Scopus22 WoS20 Europe PMC19
2016 Algate, K., Haynes, D., Bartold, P., Crotti, T., & Cantley, M. (2016). The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes. Journal of Periodontal Research, 51(5), 549-566.
DOI Scopus94 WoS88 Europe PMC72
2016 Ormsby, R., Cantley, M., Kogawa, M., Solomon, L., Haynes, D., Findlay, D., & Atkins, G. (2016). Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis. Acta Biomaterialia, 33, 242-251.
DOI Scopus66 WoS57 Europe PMC43
2016 Hynes, K., Bright, R., Proudman, S., Haynes, D., Gronthos, S., & Bartold, M. (2016). Immunomodulatory properties of mesenchymal stem cell in experimental arthritis in rat and mouse models: a systematic review. Seminars in Arthritis and Rheumatism, 46(1), 1-19.
DOI Scopus22 WoS19 Europe PMC17
2016 Cantley, M., Dharmapatni, A., Algate, K., Crotti, T., Bartold, P., & Haynes, D. (2016). Class I and II histone deacetylase expression in human chronic periodontitis gingival tissue. Journal of Periodontal Research, 51(2), 143-151.
DOI Scopus29 WoS25 Europe PMC26
2015 Crotti, T., Dharmapatni, A., Alias, E., & Haynes, D. (2015). Osteoimmunology: major and costimulatory pathway expression associated with chronic inflammatory induced bone loss. Journal of Immunology Research, 2015, 281287-1-281287-13.
DOI Scopus99 WoS90 Europe PMC85
2015 Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2015). The X-Linked Inhibitor of Apoptosis Protein inhibitor embelin suppresses inflammation and bone erosion in collagen antibody induced arthritis mice. Mediators of Inflammation, 2015(1), 564042-1-564042-10.
DOI Scopus23 WoS20 Europe PMC21
2015 Perilli, E., Cantley, M., Marino, V., Crotti, T., Smith, M., Haynes, D., & Dharmapatni, A. (2015). Quantifying not only bone loss, but also soft tissue swelling, in a murine inflammatory arthritis model using micro-computed tomography. Scandinavian Journal of Immunology, 81(2), 142-150.
DOI Scopus21 WoS19 Europe PMC16
2015 Zawawi, M., Perilli, E., Stansborough, R., Marino, V., Cantley, M., Xu, J., . . . Crotti, T. (2015). Caffeic accid phenethyl ester abrogates bone resorption in a murine calvarial model of polyethylene particle-induced osteolysis. Calcified Tissue International, 96(6), 565-574.
DOI Scopus21 WoS16 Europe PMC17
2015 Cantley, M., Fairlie, D., Bartold, P., Marino, V., Gupta, P., & Haynes, D. (2015). Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology, 54(9), 1713-1723.
DOI Scopus68 WoS66 Europe PMC57
2015 Zawawi, M., Marino, V., Perilli, E., Cantley, M., Xu, J., Purdue, P., . . . Crotti, T. (2015). Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis. Journal of Biomedical Materials Research Part A, 103(11), 3572-3579.
DOI Scopus19 WoS16 Europe PMC13
2014 Gully, N., Bright, R., Marino, V., Marchant, C., Cantley, M., Haynes, D., . . . Bartold, M. (2014). Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis. PLoS One, 9(6), e100838-1-e100838-12.
DOI Scopus96 WoS88 Europe PMC87
2013 Rainsford, K. D., & Haynes, D. R. (2013). Erratum to: Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA (vol 21, pg 269, 2013). INFLAMMOPHARMACOLOGY, 21(5), 387.
DOI
2013 Harvey, G., Fitzsimmons, T., Dharmapatni, A., Marchant, C., Haynes, D., & Bartold, P. (2013). Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. Journal of Periodontal Research, 48(2), 252-261.
DOI Scopus133 WoS117 Europe PMC104
2013 Gannon, S., Cantley, M., Haynes, D., Hirsch, R., & Bartold, P. (2013). Azithromycin suppresses human osteoclast formation and activity in vitro. Journal of Cellular Physiology, 228(5), 1098-1107.
DOI Scopus21 WoS20 Europe PMC18
2013 Cantley, M., Rainsford, K., & Haynes, D. (2013). Comparison of the ability of chondroitin sulfate derived from bovine, fish and pigs to suppress human osteoclast activity in vitro. Inflammopharmacology, 21(6), 407-412.
DOI Scopus12 WoS8 Europe PMC8
2013 Howie, D., Neale, S., Haynes, D., Holubowycz, O., McGee, M., Solomon, L., . . . Findlay, D. (2013). Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management. Inflammopharmacology, 21(6), 389-396.
DOI Scopus40 WoS35 Europe PMC28
2013 Cantley, M., Rainsford, K., & Haynes, D. (2013). Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro. Journal of Pharmacy and Pharmacology, 65(8), 1214-1222.
DOI Scopus3 WoS3 Europe PMC3
2013 Bartold, P., Du Bois, A., Gannon, S., Haynes, D., & Hirsch, R. (2013). Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis. Inflammopharmacology, 21(4), 321-338.
DOI Scopus41 WoS40 Europe PMC32
2013 Rainsford, K., & Haynes, D. (2013). Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA. Inflammopharmacology, 21(4), 269-277.
DOI WoS1
2013 Cantley, M., & Haynes, D. (2013). Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs. Inflammopharmacology, 21(4), 301-307.
DOI Scopus64 WoS60 Europe PMC50
2012 Zawawi, M., Dharmapatni, A., Cantley, M., McHugh, K., Haynes, D., & Crotti, T. (2012). Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation. Biochemical and Biophysical Research Communications, 427(2), 404-409.
DOI Scopus25 WoS22 Europe PMC18
2012 Alias, E., Dharmapatni, A., Holding, C., Atkins, G., Findlay, D., Howie, D., . . . Haynes, D. (2012). Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro. Acta Biomaterialia, 8(8), 3104-3112.
DOI Scopus21 WoS19 Europe PMC20
2012 Cantley, M., Bartold, P., Fairlie, D., Rainsford, K., & Haynes, D. (2012). Histone deacetylase inhibitors as suppressors of bone destruction in inflammatory diseases. Journal of Pharmacy and Pharmacology, 64(6), 763-774.
DOI Scopus27 WoS22 Europe PMC18
2012 Gross, K., Muller, D., Lucas, H., & Haynes, D. (2012). Osteoclast resorption of thermal spray hydoxyapatite coatings is influenced by surface topography. Acta Biomaterialia, 8(5), 1948-1956.
DOI Scopus33 WoS27 Europe PMC18
2012 Marchant, C., Smith, M., Proudman, S., Haynes, D., & Bartold, P. (2012). Effect of Porphyromonas gingivalis on citrullination of proteins by macrophages in vitro. Journal of Periodontology, Online(9), 1-15.
DOI Scopus15 WoS16 Europe PMC11
2012 Upton, A., Holding, C., Dharmapatni, A., & Haynes, D. (2012). The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatology International, 32(2), 535-540.
DOI Scopus46 WoS45 Europe PMC40
2012 Crotti, T., Dharmapatni, A., Alias, E., Zannettino, A., Smith, M., & Haynes, D. (2012). The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Research & Therapy, 14(6, article no. R245), 1-13.
DOI Scopus48 WoS45 Europe PMC41
2011 Cantley, M., Bartold, P., Marino, V., Fairlie, D., Le, G., Lucke, A., & Haynes, D. (2011). Histone deacetylase inhibitors and periodontal bone loss. Journal of Periodontal Research, 46(6), 697-703.
DOI Scopus65 WoS58 Europe PMC54
2011 Cantley, M., Fairlie, D., Bartold, P., Rainsford, K., Le, G., Lucke, A., . . . Haynes, D. (2011). Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro. Journal of Cellular Physiology, 226(12), 3233-3241.
DOI Scopus70 WoS70 Europe PMC59
2011 Dharmapatni, A., Smith, M., Crotti, T., Holding, C., Vincent, C., Weedon, H., . . . Haynes, D. (2011). TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Research & Therapy, 13(2), R51-1-R51-10.
DOI Scopus40 WoS37 Europe PMC35
2011 Cantley, M., Haynes, D., Marino, V., & Bartold, P. (2011). Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. Journal of Clinical Periodontology, 38(6), 532-541.
DOI Scopus103 WoS95 Europe PMC87
2011 Atkins, G., Haynes, D., Howie, D., & Findlay, D. (2011). Role of polyethylene particles in peri-prosthetic osteolysis: A review. World Journal of Orthopedics, 2(10), 93-101.
DOI Scopus52 WoS40 Europe PMC32
2011 Haynes, D. R. (2011). Erratum: Bone lysis and inflammation (Inflammation Research (2004) 53 (596-600)DOI 10.1007/s00011-004-1303-z). Inflammation Research, 60(10), 997.
DOI
2010 Bartold, P., Cantley, M., & Haynes, D. (2010). Mechanisms and control of pathologic bone loss in periodontitis. Periodontology 2000, 53(1), 55-69.
DOI Scopus196 WoS184 Europe PMC145
2010 Kataria, N., Bartold, P., Dharmapatni, A., Atkins, G., Holding, C., & Haynes, D. (2010). Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis. Journal of Periodontal Research, 45(4), 564-573.
DOI Scopus22 WoS22 Europe PMC17
2010 Bartold, P., Marino, V., Cantley, M., & Haynes, D. (2010). Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. Journal of Clinical Periodontology, 37(5), 405-411.
DOI Scopus81 WoS69 Europe PMC64
2010 Lucas, H., Bartold, P., Dharmapatni, A., Holding, C., & Haynes, D. (2010). Inhibition of apoptosis in periodontitis. Journal of Dental Research, 89(1), 29-33.
DOI Scopus50 WoS46 Europe PMC42
2010 Bhadang, K., Holding, C., Thissen, H., McLean, K., Forsythe, J., & Haynes, D. (2010). Biological responses of human osteoblasts and osteoclasts to flame-sprayed coatings of hydroxyapatite and fluorapatite blends. Acta Biomaterialia, 6(4), 1575-1583.
DOI Scopus53 WoS45 Europe PMC18
2009 Lacey, D., De Kok, B., Clanchy, F., Bailey, M., Speed, K., Haynes, D., . . . Hamilton, J. (2009). Low dose metal particles can induce monocyte/macrophage survival. Journal of Orthopaedic Research, 27(11), 1481-1486.
DOI Scopus14 WoS10 Europe PMC11
2009 Vincent, C., Findlay, D., Welldon, K., Wijenayaka, A., Zheng, T., Haynes, D., . . . Atkins, G. (2009). Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNF alpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. Journal of Bone and Mineral Research, 24(8), 1434-1449.
DOI Scopus160 WoS156 Europe PMC132
2009 Atkins, G., Welldon, K., Holding, C., Haynes, D., Howie, D., & Findlay, D. (2009). The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles. Biomaterials, 30(22), 3672-3681.
DOI Scopus92 WoS88 Europe PMC82
2009 Cantley, M., Bartold, P., Marino, V., Reid, R., Fairlie, D., Wyszynski, R., . . . Haynes, D. (2009). The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A₂ inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis. Journal of Periodontal Research, 44(3), 317-322.
DOI Scopus21 WoS17 Europe PMC17
2009 Dharmapatni, A., Smith, M., Findlay, D., Holding, C., Evdokiou, A., Ahern, M., . . . Haynes, D. (2009). Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. Arthritis Research & Therapy, 11(1), R13:1-R13:11.
DOI Scopus54 WoS57 Europe PMC53
2009 Cantley, M., Smith, M., & Haynes, D. (2009). Pathogenic bone loss in rheumatoid arthritis: Mechanisms and therapeutic approaches. International Journal of Clinical Rheumatology, 4(5), 561-582.
DOI Scopus15
2008 Haynes, D., Crotti, T., Weedon, H., Slavotinek, J., Au, V., Coleman, M., . . . Smith, M. (2008). Modulation of RANKL and osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis in response to disease-modifying antirheumatic drug treatment and correlation with radiologic outcome. Arthritis and Rheumatism, 59(7), 911-920.
DOI Scopus37 WoS34 Europe PMC30
2008 Shimamura, Y., Holding, C., Haynes, D., Vernon-Roberts, B., Blumbergs, P., Fraser, R., & Moore, R. (2008). The biologic response to particles from a potential disc prosthesis material. Spine, 33(4), 351-355.
DOI Scopus4 WoS4 Europe PMC4
2007 Haynes, D. (2007). Inflammatory cells and bone loss in rheumatoid arthritis. Arthritis Research & Therapy, 9(3), 3 pages.
DOI Scopus22 WoS19 Europe PMC15
2006 Haynes, D. (2006). Emerging and future therapies for the treatment of bone loss associated with chronic inflammation. Inflammopharmacology, 14(5-6), 193-197.
DOI Scopus20 Europe PMC15
2006 Holding, C., Findlay, D., Stamenkov, R., Neale, S., Lucas, H., Dharmapatni, A., . . . Haynes, D. (2006). The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants. Biomaterials, 27(30), 5212-5219.
DOI Scopus116 WoS107 Europe PMC93
2005 Krisstiansson, P., Holding, C., Hughes, S., & Haynes, D. (2005). Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?. Annals of the New York Academy of Sciences, 1041(1), 317-319.
DOI Scopus10 Europe PMC10
2005 Findlay, D., & Haynes, D. (2005). Mechanisms of bone loss in rheumatoid arthritis. Modern Rheumatology, 15(4), 232-240.
DOI Scopus47 Europe PMC33
2005 Ramaswamy, Y., Haynes, D., Berger, G., Gildenhaar, R., Lucas, H., Holding, C., & Zreiqat, H. (2005). Bioceramics composition modulate resorption of human osteoclasts. Journal of Materials Science-Materials in Medicine, 16(12), 1199-1205.
DOI Scopus35 WoS34 Europe PMC19
2005 Bartold, P., Marshall, R., & Haynes, D. (2005). Periodontitis and rheumatoid arthritis: a review. Journal of Periodontology, 76(11S), 2066-2074.
DOI Scopus242 WoS210 Europe PMC104
2005 Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., . . . Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723.
DOI Scopus146 WoS145 Europe PMC117
2005 Walker, J., Stirling, J., Beroukas, D., Dharmapatni, A., Haynes, D., Smith, M., . . . Roberts-Thomson, P. (2005). Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis. Pathology, 37(3), 220-225.
DOI Scopus31 WoS27 Europe PMC18
2005 Bartold, P. M., Marshall, R. I., & Haynes, D. R. (2005). Periodontitis and Rheumatoid Arthritis: A Review.. Journal of periodontology, 76 Suppl 11S, 2066-2074.
DOI Europe PMC71
2004 Haynes, D., & Crotti, T. (2004). Regulation of osteoclast activity in peri-implant tissues. Biomaterials, 25(20), 4877-4885.
DOI Scopus73 WoS60 Europe PMC47
2004 Haynes, D. (2004). Bone lysis and inflammation. Inflammation Research, 53(11), 596-600.
DOI Scopus59 WoS53 Europe PMC47
2004 Crotti, T., Smith, M., Findlay, D., Zreiqat, H., Ahern, M., Weedon, H., . . . Haynes, D. (2004). Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NF[kappa]B, RANK ligand and osteoprotegerin. Biomaterials, 25(4), 565-573.
DOI Scopus145 WoS131 Europe PMC118
2003 Haynes, D., & Crotti, T. (2003). Regulation of bone lysis in inflammatory diseases. Inflammopharmacology, 11(4-6), 323-331.
DOI Scopus6 Europe PMC5
2003 Zreiqat, H., Crotti, T., Howlett, C., Capone, M., Markovic, B., & Haynes, D. (2003). Prosthetic particles modify the expression of bone-related protiens by human osteoblastic cells in vitro. Biomaterials, 24(2), 337-346.
DOI Scopus30 WoS26 Europe PMC22
2003 Crotti, T., Ahern, M., Lange, K., Weedon, H., Coleman, M., Roberts-Thomson, P., . . . Smith, M. (2003). Variability of RANKL and osteoprotegerin staining in synovial tissue from patients with active rheumatoid arthritis: Quantification using color video image analysis. Journal of Rheumatology, 30(11), 2319-2324.
Scopus23 WoS20 Europe PMC15
2003 Haynes, D., Barg, E., Crotti, T., Holding, C., Weedon, H., Atkins, G., . . . Smith, M. (2003). Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls. Rheumatology, 42(1), 123-134.
DOI Scopus136 WoS123 Europe PMC100
2003 Zreiqat, H., Akin, F., Howlett, C., Markovic, B., Haynes, D., Lateef, S., & Hanley, L. (2003). Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 64A(1), 105-113.
DOI Scopus78 WoS64 Europe PMC48
2003 Crotti, T., Smith, M., Hirsch, R., Soukoulis, S., Weedon, H., Capone, M., . . . Haynes, D. (2003). Receptor activator NF kB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis. Journal of Periodontal Research, 38(4), 380-387.
DOI Scopus256 WoS236 Europe PMC195
2002 Atkins, G., Bouralexis, S., Evdokiou, A., Hay, S., Labrinidis, A., Zannettino, A., . . . Findlay, D. (2002). Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. Bone, 31(4), 448-456.
DOI Scopus60 WoS60 Europe PMC48
2002 Crotti, T., Smith, M., Weedon, H., Ahern, M., Findlay, D., Kraan, M., . . . Haynes, D. (2002). Receptor activator NFκB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis. Annals of the Rheumatic Diseases, 61(12), 1047-1054.
DOI Scopus174 WoS158 Europe PMC132
2002 Moore, R., Fraser, R., Vernon-Roberts, B., Finnie, J., Blumbergs, P., Haynes, D., . . . Koszyca, B. (2002). The biologic response to particles from a lumbar disc prosthesis. Spine, 27(19), 2088-2094.
DOI Scopus31 WoS26 Europe PMC22
2002 Atkins, G., Haynes, D., Zannettino, A., Capone, M., Crotti, T., & Findlay, D. (2002). Haemopoietic cells influence stromal cell gene expression during human osteoclast development. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 235.
2002 Atkins, G., Crotti, T., Loric, M., Findlay, D., Howie, D., Bain, G., & Haynes, D. (2002). Periprosthetic osteolysis is associated with wear particles stimulating factors that control osteoclast formation. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 234.
2002 Atkins, G., Crotti, T., Loric, M., Findlay, D., Smith, M., & Haynes, D. (2002). Osteolysis in bone loss pathologies is associated with similar factors that control osteoclast formation. Asia Pacific Orthopaedic Association.. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 234-235.
2001 Haynes, D., Crotti, T., Loric, M., Bain, G., Atkins, G., & Findlay, D. (2001). Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint. Rheumatology, 40(6), 623-630.
DOI Scopus188 WoS168 Europe PMC138
2001 Haynes, D., Crotti, T., Potter, A., Loric, M., Atkins, G., Howie, D., & Findlay, D. (2001). The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis. Journal of Bone and Joint Surgery-British Volume, 83B(6), 902-911.
DOI Scopus170 WoS142 Europe PMC108
2001 Atkins, G., Bouralexis, S., Haynes, D., Graves, S., Geary, S., Evdokiou, A., . . . Findlay, D. (2001). Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone. Bone, 28(4), 370-377.
DOI Scopus86 WoS83 Europe PMC68
2001 Dalidjan, M., Pierce, A. M., Wilson, D. F., Crotti, T. N., Capone, M., & Haynes, D. R. (2001). The presence of regulators of osteoclast formation in periodontal disease.. JOURNAL OF DENTAL RESEARCH, 80(4), 978.
2001 Crotti, T. N., Smith, M. D., Weedon, H., Capone, M., Holding, C., Findlay, D. M., & Haynes, D. R. (2001). Osteoprotegerin (OPG) and RANKL expression in tissues near bone in diseases of pathological bone loss: A comparison of rheumatoid arthritis, prosthetic joint failure and periodontal disease.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S227.
WoS1
2000 Atkins, G., Haynes, D., Graves, S., Evdokiou, A., Hay, S., Bouralexis, S., & Findlay, D. (2000). Expression of osteoclast differentiation signals by stromal elements of giant cell tumors. Journal of Bone and Mineral Research, 15(4), 640-649.
DOI Scopus167 WoS167 Europe PMC131
2000 Neale, S., Haynes, D., Howie, D., Murray, D., & Athanasou, N. (2000). The effect of particle phagocytosis and metallic wear particles on osteoclast formation and bone resorption in vitro. Journal of Arthroplasty, 15(5), 654-662.
DOI Scopus53 WoS49 Europe PMC43
2000 Mc Gee, M., Howie, D., Tsirgiotis, K., Haynes, D., Wildenauer, C., Pearcy, M., & McLean, J. (2000). Implant retrieval studies of the wear and loosening of prosthetic joints: a review. Wear, 241(2), 158-165.
DOI Scopus101 WoS86
2000 Haynes, D., Crotti, T., & Haywood, M. (2000). Corrosion of and changes in biological effects of cobalt chrome alloy and 316L staianless steel prosthetic particles with age. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 49(2), 167-175.
DOI Scopus76 WoS71 Europe PMC30
2000 Haynes, D., Harkin, D., Bignold, L., Hutchens, M., Taylor, S., & Fairlie, D. (2000). Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production In vitro by a new C5a receptor antagonist. Biochemical Pharmacology, 60(5), 729-733.
DOI Scopus57 WoS56 Europe PMC40
2000 Atkins, G., Haynes, D., Geary, S., Loric, M., Crotti, T., & Findlay, D. (2000). Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation. Bone, 26(6), 653-661.
DOI Scopus69 WoS65 Europe PMC52
1999 Haynes, D., Atkins, G., Loric, M., Crotti, T., Geary, S., & Findlay, D. (1999). Bidirectional signaling between stromal and hemopoietic cells regulates interleukin-1 expression during human osteoclast formation. Bone, 25(3), 269-278.
DOI Scopus40 WoS34 Europe PMC28
1999 Atkins, G. J., Haynes, D. R., Graves, S. E., Evdokiou, A., Hay, S., Bouralexis, S., . . . Findlay, D. M. (1999). Expression of osteoclast differentiation signals by stromal elements of giant cell tumours.. JOURNAL OF BONE AND MINERAL RESEARCH, 14, S176.
WoS1
1998 Pierce, A. M., Haynes, D. R., Loric, M., Findlay, D., Dreyer, C., & Vernon-Roberts, B. (1998). The use of animal and human model systems to study tooth and bone resorption <i>in vitro</i>.. JOURNAL OF DENTAL RESEARCH, 77, 721.
1998 Haynes, D., Hutchens, M., Whitehouse, M., & Vernon-Roberts, B. (1998). A comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats. Inflammopharmacology, 6(3), 193-202.
DOI Scopus3 Europe PMC2
1998 Pentilla, I., Harris, R., Storm, P., Haynes, D., Worswick, D., & Marmion, B. (1998). Cytokine dysregulation in the post-Q-fever fatigue syndrome. QJM, 91(8), 549-560.
DOI Scopus93 WoS75 Europe PMC59
1998 Haynes, D., Boyle, S., Rogers, S., Howie, D., & Vernon-Roberts, B. (1998). Variation in cytokines induced by particles from different prosthetic materials. Clinical Orthopaedics and Related Research, 352(352), 223-230.
DOI Scopus105 WoS95 Europe PMC26
1997 McGee, M., Howie, D., Neale, S., Haynes, D., & Pearcy, M. (1997). The role of polyethylene wear in joint replacement failure. Proceedings of the Institution of Mechanical Engineers, Part H, 211(1), 65-72.
DOI Scopus53 WoS37 Europe PMC12
1997 Rogers, S., Howie, D., Graves, S., Pearcy, M., & Haynes, D. (1997). In vitro human monocyte response to wear particles of titanium alloy containing vanadium or niobium. Journal of Bone and Joint Surgery (British), 79-B(2), 311-315.
DOI Scopus154 WoS140 Europe PMC65
1997 Haynes, D., Hay, S., Rogers, S., Ohta, S., Howie, D., & Graves, S. (1997). Regulation of bone cells by particle-activated mononuclear phagocytes. Journal of Bone and Joint Surgery, 79B(6), 988-994.
DOI Scopus67 WoS57 Europe PMC42
1997 Whitehouse, M., Macrides, T., Kalafatis, N., Betts, W., Haynes, D., & Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 5(3), 237-246.
DOI Scopus131
1997 Youssef, P., Haynes, D., Triantafillou, S., Parker, A., Gamble, J., Roberts-Thomson, P., . . . Smith, M. (1997). Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis. Arthritis and Rheumatism, 40(8), 1400-1408.
DOI Scopus112 WoS110 Europe PMC79
1996 Howie, D., Rogers, S., McGee, M., & Haynes, D. (1996). Biologic effects of cobalt chrome in cell and animal models. Clinical Orthopaedics and Related Research, 329(Suppl), S217-S232.
DOI Scopus113 WoS42 Europe PMC40
1996 Haynes, D., Rogers, S., Howie, D., Pearcy, M., & Vernon-Roberts, B. (1996). Drug inhibition of the macrophage response to metal wear particles in vitro. Clinical Orthopaedics and Related Research, 323(323), 316-326.
DOI Scopus48 WoS22 Europe PMC19
1996 Haynes, D., & Vernon-Roberts, B. (1996). Prospects for non-surgical intervention in artificial joint loosening. Journal of Orthopaedic Rheumatology, 9(2), 74-77.
1996 Haynes, D., Gadd, S., Whitehouse, M., Mayrhofer, G., & Vernon-Roberts, B. (1996). Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production. Inflammation Research, 45(4), 159-165.
DOI Scopus15 WoS10 Europe PMC10
1995 Haynes, D., & Vernon-Roberts, B. (1995). Potential pharmacological treatments of prosthetic joint loosening. Inflammopharmacology, 3(3), 213-219.
DOI Scopus4
1994 Rofe, A. M., Philcox, J. C., Haynes, D. R., & Coyle, P. (1994). Wasting in adjuvant-induced arthritis and its relationship to plasma zinc, copper and liver metallothionein. Agents and Actions, 42(1-2), 60-62.
DOI Scopus9 Europe PMC6
1994 Wright, P. F. A., Stacey, N. H., & Haynes, D. R. (1994). Effects of piroxicam and misoprostol on cytokine release from human liver immune cells. In Vitro Toxicology Journal of Molecular and Cellular Toxicology, 7(2), 113-118.
1993 Howie, D. W., Haynes, D. R., Rogers, S. D., McGee, M. A., & Pearcy, M. J. (1993). The response to particulate debris. Orthopedic Clinics of North America, 24(4), 571-581.
Scopus134 WoS118 Europe PMC42
1993 Haynes, D. R., Rogers, S. D., Hay, S., Pearcy, M. J., & Howie, D. W. (1993). The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles. Journal of Bone and Joint Surgery Series A, 75(6), 825-834.
DOI Scopus382 WoS348 Europe PMC192
1993 Haynes, D. R., Wright, P. F. A., Gadd, S. J., Whitehouse, M. W., & Vernon-Roberts, B. (1993). Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites. Agents and Actions, 39(1-2), 49-58.
DOI Scopus36 Europe PMC25
1993 Rogers, S. D., Pearcy, M. J., Hay, S. J., Haynes, D. R., Bramley, A., & Howie, D. W. (1993). A method for production and characterization of metal prosthesis wear particles. Journal of Orthopaedic Research, 11(6), 856-864.
DOI Scopus32 WoS30 Europe PMC15
1992 Haynes, D. R., Whitehouse, M. W., & Vernon-Roberts, B. (1992). The prostaglandin E1 analogue, Misoprostol, regulates inflammatory cytokines and immune functions in vitro like the natural prostaglandins E1, E2 and E3. Immunology, 76(2), 251-257.
Scopus115 Europe PMC81
1992 Rofe, A. M., Philcox, J. C., Haynes, D. R., Whitehouse, M. W., & Coyle, P. (1992). Changes in plasma zinc, copper, iron, and hepatic metallothionein in adjuvant-induced arthritis treated with cyclosporin. Biological Trace Element Research, 34(3), 237-248.
DOI Scopus22 Europe PMC19
1991 Haynes, D. R., Whitehouse, M. W., & Vernon-Roberts, B. (1991). The effects of some anti-arthritic drugs and cytokines on the shape and function of rodent macrophages. International Journal of Experimental Pathology, 72(1), 9-22.
Scopus11 Europe PMC4
1991 Bartold, P. M., & Haynes, D. R. (1991). Interleukin‐6 production by human gingival fibroblasts. Journal of Periodontal Research, 26(4), 339-345.
DOI Scopus120 WoS119 Europe PMC109
1990 Rofe, A. M., Whitehouse, M. W., Bourgeois, C. S., Haynes, D. R., & Vernon‐Roberts, B. (1990). Prevention of adjuvant‐induced cachexia in rats by cyclosporin A. Immunology and Cell Biology, 68(1), 63-69.
DOI Scopus12 Europe PMC8
1990 Bignold, L. P., Ferrante, A., & Haynes, D. R. (1990). Studies of chemotactic, chemotactic movement-inhibiting and random movement-inhibiting effects of interleukin-1 alpha and beta, tumour necrosis factors alpha and beta and interferon gamma on human neutrophils in assays using 'sparse-pore' polycarbonate (Nuclepore) membranes in the boyden chamber. International Archives of Allergy and Immunology, 91(1), 1-7.
DOI Scopus17 WoS20 Europe PMC10
1990 Haynes, D. R., Wright, P. F., Whitehouse, M. W., & Vernon‐Roberts, B. (1990). The cyclo‐oxygenase inhibitor, Piroxicam, enhances cytokine‐induced lymphocyte proliferation in vitro and in vivo. Immunology and Cell Biology, 68(4), 225-230.
DOI Scopus13 Europe PMC13
1989 Smith, M. D., Haynes, D. R., & Roberts-Thomson, P. J. (1989). Interleukin 2 and interleukin 2 inhibitors in human serum and synovial fluid. I. Characterization of the inhibitor and its mechanism of action. Journal of Rheumatology, 16(2), 149-157.
Scopus8 Europe PMC5
1989 Bartold, P. M., Haynes, D. R., & Vernon‐Roberts, B. (1989). Effect of mitogen and lymphokine stimulation on proteoglycan synthesis by lymphocytes. Journal of Cellular Physiology, 140(1), 82-90.
DOI Scopus20 WoS23 Europe PMC13
1988 Haynes, D. R., Garrett, I. R., & Vernon-Roberts, B. (1988). Effect of gold salt treatment on the receptor binding activity of monocytes and macrophages isolated from rats with adjuvant arthritis. Rheumatology International, 8(4), 159-164.
DOI Scopus9 Europe PMC10
1988 Haynes, D. R., Garrett, I. R., Whitehouse, M. W., & Vernon-Roberts, B. (1988). Do gold drugs inhibit interleukin-1? Evidence from an in vitro lymphocyte activating factor assay. Journal of Rheumatology, 15(5), 775-778.
Scopus20 Europe PMC18
1984 Manning, P. A., & Haynes, D. R. (1984). A common-immunogenic Vibrio outer membrane protein. FEMS Microbiology Letters, 24(2-3), 297-302.
DOI Scopus17
1982 Manning, P. A., Imbesi, F., & Haynes, D. R. (1982). Cell envelope proteins in Vibrio cholerae. FEMS Microbiology Letters, 14(3), 159-166.
DOI Scopus31

Year Citation
2011 Dharmapatni, A., Fitzpatrick, D., Cantley, M. D., & Haynes, D. R. (2011). INCREASED SOFAT MRNA EXPRESSION DURING OSTEOCLAST DEVELOPMENT, EVIDENCE THAT SOFAT IS NOT ONLY ASSOCIATED WITH T CELLS. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Atkins, G. J., Vincent, C., Wijenayaka, A. R., Welldon, K. J., Haynes, D. R., Zheng, T. S., . . . Findlay, D. M. (2011). THE EFFECTS OF TWEAK AND TNF ON HUMAN OSTEOBLASTS: MAPK DEPENDENT INDUCTION OF SCLEROSTIN EXPRESSION. In D. Wallach, A. Kovalenko, & M. Feldman (Eds.), ADVANCES IN TNF FAMILY RESEARCH Vol. 691 (pp. 688). San Lorenzo del Escorial, SPAIN: SPRINGER-VERLAG BERLIN.
2011 Crotti, T. N., Zawawi, M. S., Dharmapatni, A. A., Cantley, M. D., & Haynes, D. R. (2011). INHIBITION OF ITAM ADAPTOR MOLECULES AND THEIR RECEPTORS BY INHIBITION OF CALCINEURIN-NFAT SIGNALLING DURING LATE STAGE HUMAN OSTEOCLAST DIFFERENTIATION. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Dharmapatni, A. A. S., Gillard, J. W., Rainsford, K. D., & Haynes, D. R. (2011). REGULATION OF HUMAN OSTEOCLAST ACTIVITY AND APOPTOSIS BY IAP INHIBITORS IN VITRO. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603-S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Cantley, M. D., Fairlie, D. P., Bartold, P., Marino, V., & Haynes, D. R. (2011). INHIBITING HISTONE DEACETYLASES EXPRESSED IN HUMAN PERIODONTAL TISSUES PREVENTS BONE LOSS IN AN ANIMAL MODEL OF PERIODONTAL DISEASE. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S613). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2010 Haynes, D. R., Dharmapatni, K., Smith, M. D., Chen, D. Y., Holding, C. A., Weedon, H., & Upton, A. (2010). A ROLE FOR TNF-LIKE WEAK INDUCER OF APOPTOSIS (TWEAK) DERIVED FROM SYNOVIAL TISSUES AND CARTILAGE IN THE PATHOGENESIS OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S100). Brussels, BELGIUM: W B SAUNDERS CO LTD.
DOI
2010 Cantley, M., Haynes, D. R., & Rainsford, K. D. (2010). EFFECTS OF RIBONUCLEINATE COMPONENTS OF OSTEOCHONDRIN<SUP>R</SUP> S OSTEOARTHRITIS THERAPY ON FORMATION AND ACTIVITY OF HUMAN OSTEOCLASTS <i>IN VITRO</i>. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S254-S255). Brussels, BELGIUM: W B SAUNDERS CO LTD.
DOI WoS1
2009 Wijenayaka, A. R., Vincent, C., Findlay, D. M., Welldon, K. J., Zheng, T. S., Haynes, D. R., . . . Atkins, G. J. (2009). The proinflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFa induce the mitogen activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. In BONE Vol. 44 (pp. S63). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI WoS1
2009 Welldon, K. J., Holding, C., Haynes, D. R., Howie, D. W., Findlay, D. M., & Atkins, G. J. (2009). Polyethylene particles activate pro-osteoclastogenic signalling pathways in human primary osteoblasts and osteocytes. In BONE Vol. 44 (pp. S127-S128). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI
2009 Cantley, M. D., Fairlie, D. P., Bartold, M. P., Rainsford, K. D., & Haynes, D. R. (2009). Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro. In BONE Vol. 44 (pp. S133-S134). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI WoS1
2008 Atkins, G. J., Vincent, C., Wijenayaka, A. R., Welldon, K. J., Haynes, D. R., Zheng, T. S., . . . Findlay, D. M. (2008). The Proinflammatory Cytokine TWEAK Induces Sclerostin Expression in Human Immature Osteoblasts in a MAPK Dependent Fashion.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 23 (pp. S385). Montreal, CANADA: AMER SOC BONE & MINERAL RES.
2007 Atkins, G. J., Vincent, C., Welldon, K. J., Haynes, D. R., Holding, C., Zheng, T. S., . . . Findlay, D. M. (2007). TWEAK is a regulator of human osteoblast function. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S138). Honolulu, HI: AMER SOC BONE & MINERAL RES.
2006 Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., & Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. In Key Engineering Materials Vol. 309-311 I (pp. 709-712). Trans Tech Publications Ltd..
DOI Scopus3
2005 Dharmapatni, A. A. S. S. K., Findlay, D. M., Smith, M. D., Evdokiou, A., Chen, P., Screaton, G. R., . . . Haynes, D. R. (2005). Regulating the sensitivity of synovial fibroblasts to trail-induced apoptosis. In ANNALS OF THE RHEUMATIC DISEASES Vol. 64 (pp. 154). Vienna, AUSTRIA: BMJ PUBLISHING GROUP.
2004 Lucas, H., Zreiqat, H., Gross, K. A., Holding, C., Findlay, D. M., Wallwork, M., & Haynes, D. R. (2004). Osteoclast resorption of hydroxyapatite bone substitute materials in vitro. In Transactions 7th World Biomaterials Congress (pp. 1309).
2004 Peters, K., Haynes, D. R., Crotti, T. N., Unger, R. E., & Kirkpatrick, C. J. (2004). Effects of wear particles from metallic implant materials on the pro-inflammatory state of endothelial cells in vitro. In Transactions 7th World Biomaterials Congress (pp. 1150).
1999 Atkins, G. J., Loric, M., Crotti, T. N., Haynes, D. R., & Findlay, D. M. (1999). Osteoclast differentiation factors are expressed by both stromal and haematopoietic cells in human osteoclast formation. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 547-551). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD.
1999 Crotti, T. N., Potter, A. E., Atkins, G. J., Findlay, D. M., Howie, D. W., & Haynes, D. R. (1999). Osteoclast differentiation and development is regulated by mediators released in response to prosthetic particles. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 542-546). AUSTRALIA, SYDNEY: FREUND PUBL HOUSE LTD.

Year Citation
2016 Crotti, T. N., Coleman, R., Dharmapatni, A. A., Weedon, H., Haynes, D. R., Smith, M. D., & Wechalekar, M. D. (2016). EXPRESSION OF OSCAR IN THE SYNOVIUM OF EARLY RA PATIENTS. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP.
DOI
2014 Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2014). THE X-LINKED INHIBITORY OF APOPTOSIS PROTEIN INHIBITOR, EMBELIN SUPPRESSES INFLAMMATION AND BONE EROSION IN COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA) MICE. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2013 Dharmapatni, A., Coleman, R., Lorimer, M., Zannettino, A., Weedon, H., Wechalekar, M., . . . Crotti, T. (2013). Relationship between Soluble OSCAR and Disease Activity: A 12 Month Study of Newly Diagnosed RA Patients. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Baltimore, MD: WILEY-BLACKWELL.
1998 Irani, D. M., Pierce, A. M., Gully, N. J., Haynes, D. R., & Wilson, D. F. (1998). <i>Eikenella corrodens</i> surface associated material stimulates osteolytic cytokines.. Poster session presented at the meeting of JOURNAL OF DENTAL RESEARCH. AMER ASSOC DENTAL RESEARCH.
1998 Irani, D. M., Pierce, A. M., Haynes, D. R., Gully, N. J., & Wilson, D. F. (1998). <i>Eikenella corrodens</i> surface associated material stimulates osteolytic cytokines.. Poster session presented at the meeting of JOURNAL OF DENTAL RESEARCH. SAGE PUBLICATIONS INC.
Date Project/ No. Investigators Funding Body Amount
1991-1994 Arthritis : Mechanisms of initiation and their modulation by drugs. / #31264

Vernon-Roberts B, Whitehouse MW, Haynes DR

 NHMRC $238622
1994 Wear particle induced bone resorption causing joint replacement loosening. / #31965

Howie DW, Vernon-Roberts B, Haynes DR

 NHMRC $133454
1994 Arthritis: Manipulating endogenous mediators to optimise treatment. / #32432

Vernon-Roberts B, Whitehouse MW, Haynes DR

 NHMRC $60,152
1996-1998 Cell biology and drug control of loosening of joint prostheses. / #34313

Vernon-Roberts B, Howie DW, Haynes DR, Graves SE

 NHMRC $161100
1998-2000 Requirements for human osteoclast generation. / #35252

Findlay DM, Haynes DR, Howie DW

 NHMRC $166,000
2000-2002 Cell regulation of periprosthetic bone loss. / #104818*

Haynes DR, Findlay DM, Vernon-Roberts B, Howie DW

 NHMRC $318,630
2001-2003 Requirements for human osteoclast generation. / #157984

Findlay DM, Atkins GJ, Haynes DR, Zannetino A

 NHMRC $273,000
2003-2005 Mechanisms of periprosthetic bone loss. / #250344

Findlay DM, Haynes DR, Howie DW, McGee MA

 NHMRC $315,000
2005-2007 Improving orthopaedic/dental devices by surface chemical modification / #DP0556403

Zreiqat H, Swain MV, Haynes DR, Anderson G

 ARC $555,000
2004-2006 Regulation of bone resorption in periodontal disease. / #299028

Haynes DR, Bartold PM, Findlay DM, Gully NJ

 NHMRC

 $254,750
2004-2006 Inducing normal bone remodelling at the medical device/ bone interface. / #300487

Zreiqat H , Haynes DR

 NHMRC $468,250
2006 -2008 Impaired bone remodelling leads to failure of orthopaedic prostheses. / #399168

Findlay DM, Haynes DR, Howie DW, Atkins GJ, Crotti TN

 NHMRC $515,917
2007-2009 The role of TNF family members TWEAK and TNF-alpha in bone remodelling./ #453605

Atkins GJ, Findlay DM, Haynes DR, Zheng TS, Zannetino A

 NHMRC $544,500
2007-2009 Regulation of Osteoclasts in Bone Pathologies./ #453568

Haynes DR, Bartold PM, Smith MD, Rainsford KD

 NHMRC $566,947
2009-2012 Regulation of key pathways causing peri-implant bone loss./ #565361

Haynes DR, Findlay DM, Atkins GA, Howie DW, Crotti TN

NHMRC $536,613
2011-2013 Sclerostin effects on bone mineralisation and catabolism. / #1004871

GJ Atkins, Findlay DM, Haynes DR

 NHMRC $536,653
2012-2014 Periodontal disease and rheumatoid arthritis / #1023747

Bartold PM , Haynes DR, Smith MD, Proudman S

 NHMRC $536,128
2013-2015 Particle induced osteolysis and osteocytes / #1041456

GJ Atkins, Haynes DR, Findlay DM

 NHMRC $449,619
2014-2016 HDAC 1 and 5 in periodontitis / #1057853

Haynes DR, Bartold PM , Cantley MD

 NHMRC $518,901
2014-2017 An international network on new strategies for processing calcium phosphates.

Riga Technical University, University of Riga, Universite de Technologie de Belfort Montbeliard, University College London, Ludwig Boltzmann Gesellschaft, University de Limoges

European Community Seventh

Framework Programme Grant

  
Teaching

Course coordinator of the compulsory second year course Biology of Disease in the Bachelor of Health Sciences program.

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2021 Co-Supervisor Studies on the Functions of Latent Transforming Growth Factor Beta (TGF-Beta) Binding Protein-2 (LTBP-2) in the Regulation of TGF-Beta 1 and Fibrosis Progression Doctor of Philosophy Doctorate Full Time Mr Yike You
2015 - 2020 Principal Supervisor Osteochondroreticular Stem Cell Therapy for Osteoarthritis: The right cells for the job Doctor of Philosophy Doctorate Full Time Miss Jia Ng
2014 - 2018 Principal Supervisor Epigenetic Regulation of Cells Involved in Periodontal Bone Destruction Through Targeted Histone Deacetylase Inhibition Doctor of Philosophy Doctorate Full Time Kent Algate
2012 - 2016 Co-Supervisor Function of Latent Transforming Growth Factor-B Binding Protein-2 (LTBP-2) in Elastinogenesis and Modulation of Growth Factor Storage, Expression and Activity in Normal and Fibrotic Tissues Doctor of Philosophy Doctorate Full Time Mr Mohamed Arshad Mohamed Sideek
2011 - 2015 Principal Supervisor Targeting NF-kappaB and NFATc1 signalling to inhibit bone resorption in peri-prosthetic osteolysis Doctor of Philosophy Doctorate Full Time Mr Muhamad Syahrul Fitri Zawawi
2010 - 2013 Principal Supervisor Targeting Histone Deacetylases to Suppress Bone Loss in Similar Chronic Inflammatory Diseases, Periodontitis and Rheumatoid Arthritis. Doctor of Philosophy Doctorate Full Time Dr Melissa Cantley
2008 - 2014 Principal Supervisor Osteoclast-associated Intracellular ITAM Signalling Molecules in Human Peri-implant Osteolysis and Rheumatoid Arthritis Doctor of Philosophy Doctorate Full Time Mr Ekram Alias
2003 - 2007 Principal Supervisor Trail Mediated Apoptosis in Arthritis Doctor of Philosophy Doctorate Full Time Ms Anak Dharmapatni
1999 - 2002 Principal Supervisor MEDIATORS OF LOCALISED PATHOLOGICAL BONE LOSS Doctor of Philosophy Doctorate Full Time APrf Tania Crotti
1997 - 2003 Principal Supervisor IMMUNOGENETIC DETERMINANTS OF CHRONIC Q FEVER Doctor of Philosophy Doctorate Full Time Dr Karla Helbig

Date Role Committee Institution Country
2016 - ongoing Member International Combined Orthopaedic Societies for the Scientific Meeting in Xian - -
2007 - 2013 Member Combined Orthopaedic Research Societies (CORS) - -

Date Role Membership Country
2006 - 2009 President Australian New Zealand Orthopaedic Research Society Australia
2003 - 2006 Secretary Australian New Zealand Orthopaedic Research Society Australia
1999 - 2016 Member Australian New Zealand Bone and Mineral Society Australia

Date Institution Department Organisation Type Country
2013 - 2016 Advisory Board of the Bone Foundation - - -

Date Role Editorial Board Name Institution Country
2007 - ongoing Associate Editor Inflammopharmacology - -

Date Office Name Institution Country
2006 - 2013 Australian representative and committee member of The International Orthopaedic Research Societies - -
2006 - 2009 President of the Australian and New Zealand Society of Orthopaedic Research - Australia
2003 - 2006 Secretary (2003-6) of the Australian and New Zealand Society of Orthopaedic Research (www.ANZORS.org.au) - Australia

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