Anak Dharmapatni

Research Interests

Arthritis & Rheumatology Dentistry

Dr Anak Dharmapatni

School of Pharmacy and Biomedical Science

College of Health

Dr Anak Dharmapatni completed her PhD in the Discipline of Anatomy and Pathology, School of Medicine, the University of Adelaide in 2007, and MSc in Immunology, Allergy and arthritis, Flinders University in 2002, and MBBS and MD in 1991 and 1987 in Indonesia. Currently she is a post doctoral researcher and academic in the School of Medicine and Dentistry the University of Adelaide. She has obtained grants in arthritis and dental fields, published more than 20 papers and a regular reviewer for many scientific journals. She review grants for funding bodies such as NHMRC and United States-Israel Binational Science Foundation.

My research interests include human diseases associated with auto-immunity, in particular Rheumatoid Arthritis (RA) and systemic sclerosis. However, I am also interested in other forms of arthritis such as osteoarthritis and psoriatic arthritis. In recent years I have focused primarily on chronic inflammation-induced bone loss, such as chronic periodontitis and peri-implant osteolysis. With regards to cellular and molecular processes, my research focuses particularly on apoptosis, autophagy and osteoclast signaling. These are research strengths within the bone and joint lab, discipline of Anatomy and Pathology School of Medical Sciences. These research focuses have great potential for cross disciplinary studies and research collaborations, as demonstrated in a number of our publications.

I have also been successful in attaining various grants since 2012 until recently. These grants were awarded by the Arthritis Australia, the American Society of Bone and Mineral Research (ASBMR) and by the Australian Dental Research Foundation (ADRF).

I have collaborated with various research groups, both nationally and internationally, and continue to do so. Presently, I collaborate with the Colgate Australian Clinical Dental Research Centre, the Orthodontic Unit within the School of Dentistry, the Rheumatology Research Unit at the Repatriation Hospital, and Orthopaedics and Trauma at the University of Adelaide. I have also had international collaborations with Biogen Idec Inc., Cambridge Centre, Cambridge, Department of Medicine Imperial College London (Professor Gavin R. Screaton), Aegera Inc, Canada and SRI International, CA, USA.

 

I have contributed to my research fields by reviewing numerous scientific journals and grant proposals, and continue to do so. In the past few years I have been invited to review articles for various scientific journals such as Inflammopharmacology, Rheumatology (Oxford), Journal of Inflammation, Journal of Clinical Experimental Immunology, Journal of Histology and Histopathology, Journal of Periodontology, Journal of Cellular Physiology, Journal of Clinical Intervention of Aging, Journal of Human Immunology, Journal of Inflammation Research and Journal Pharma, International Journal of Molecular Sciences (IJMS), Calcified tissue International, PLOS one, Arthritis Research and Therapy. I have been a regular reviewer for the Journal of Periodontal Research, Journal of Human Immunology and Rheumatology (Oxford), which demonstrates my capacity to contribute to worldwide research.

National and international funding bodies have also invited me to review grant proposals. Some of these reviews include grant proposals from the United State-Israel Binational Foundation (BSF) for grant applications for funding the years 2013 and 2014. This demonstrates the recognition of my expertise by an International organization. More recently, I have been invited by the NHMRC to review a project grant for the 2014 project grant funding scheme.

 

Supervision of high degree research students is an integral part of my research activities. Currently, I am assigned to supervise postgraduate research students in both the School of Medical Sciences and the School of Dentistry.

 

Date Position Institution name
2017 - ongoing Lecturer University of Adelaide
2008 - 2015 Post Doctoral Researcher and casual teaching academic The University of Adelaide

Date Type Title Institution Name Country Amount
2016 Research Award Arthritis Australia Project Grant 2016 The University of Adelaide Australia AUD$25,000
2015 Research Award Marion A Simpson grant funded by the State of the Late Marion Alice Simpson. University of Adelaide Australia AUD $25,000

Language Competency
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2003 - 2007 The University of Adelaide Australia PhD

Year Citation
2024 Darmawan, I. G. N., & Dharmapatni, A. A. S. S. K. (2024). A multilevel analysis of student and school characteristics associated with 15-year-olds’ reading performances: a Southeast Asian perspective. Large-Scale Assessments in Education, 12(1), 26 pages.
DOI Scopus3 WoS3
2018 Williams, B., Dharmapatni, A., & Crotti, T. (2018). Intracellular apoptotic pathways: a potential target for reducing joint damage in rheumatoid arthritis. Inflammation Research, 67(3), 219-231.
DOI Scopus23 WoS21 Europe PMC14
2017 Williams, B., Tsangari, E., Stansborough, R., Marino, V., Cantley, M., Dharmapatni, A., . . . Crotti, T. (2017). Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis. Inflammopharmacology, 25(1), 55-68.
DOI Scopus11 WoS10 Europe PMC7
2017 Dharmapatni, A., Algate, K., Coleman, R., Lorimer, M., Cantley, M., Smith, M., . . . Crotti, T. (2017). Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro. Inflammation, 40(5), 1566-1575.
DOI Scopus10 WoS10 Europe PMC9
2016 Saad, S., Dharmapatni, A., Crotti, T., Cantley, M., Algate, K., Findlay, D., . . . Haynes, D. (2016). Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss. Acta Biomaterialia, 30, 311-318.
DOI Scopus22 WoS20 Europe PMC19
2016 Cantley, M., Dharmapatni, A., Algate, K., Crotti, T., Bartold, P., & Haynes, D. (2016). Class I and II histone deacetylase expression in human chronic periodontitis gingival tissue. Journal of Periodontal Research, 51(2), 143-151.
DOI Scopus29 WoS25 Europe PMC26
2015 Crotti, T., Dharmapatni, A., Alias, E., & Haynes, D. (2015). Osteoimmunology: major and costimulatory pathway expression associated with chronic inflammatory induced bone loss. Journal of Immunology Research, 2015, 281287-1-281287-13.
DOI Scopus99 WoS90 Europe PMC85
2015 Doyle, C., Fitzsimmons, T., Marchant, C., Dharmapatni, A., Hirsch, R., & Bartold, P. (2015). Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro. Clinical Oral Investigations, 19(2), 221-227.
DOI Scopus33 WoS31 Europe PMC22
2015 Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2015). The X-Linked Inhibitor of Apoptosis Protein inhibitor embelin suppresses inflammation and bone erosion in collagen antibody induced arthritis mice. Mediators of Inflammation, 2015(1), 564042-1-564042-10.
DOI Scopus23 WoS20 Europe PMC21
2015 Perilli, E., Cantley, M., Marino, V., Crotti, T., Smith, M., Haynes, D., & Dharmapatni, A. (2015). Quantifying not only bone loss, but also soft tissue swelling, in a murine inflammatory arthritis model using micro-computed tomography. Scandinavian Journal of Immunology, 81(2), 142-150.
DOI Scopus21 WoS19 Europe PMC16
2015 Zawawi, M., Perilli, E., Stansborough, R., Marino, V., Cantley, M., Xu, J., . . . Crotti, T. (2015). Caffeic accid phenethyl ester abrogates bone resorption in a murine calvarial model of polyethylene particle-induced osteolysis. Calcified Tissue International, 96(6), 565-574.
DOI Scopus21 WoS16 Europe PMC17
2015 Zawawi, M., Marino, V., Perilli, E., Cantley, M., Xu, J., Purdue, P., . . . Crotti, T. (2015). Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis. Journal of Biomedical Materials Research Part A, 103(11), 3572-3579.
DOI Scopus19 WoS16 Europe PMC13
2013 Harvey, G., Fitzsimmons, T., Dharmapatni, A., Marchant, C., Haynes, D., & Bartold, P. (2013). Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. Journal of Periodontal Research, 48(2), 252-261.
DOI Scopus133 WoS117 Europe PMC104
2012 Crotti, T., Dharmapatni, A., Alias, E., Zannettino, A., Smith, M., & Haynes, D. (2012). The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Research & Therapy, 14(6, article no. R245), 1-13.
DOI Scopus49 WoS46 Europe PMC41
2012 Zawawi, M., Dharmapatni, A., Cantley, M., McHugh, K., Haynes, D., & Crotti, T. (2012). Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation. Biochemical and Biophysical Research Communications, 427(2), 404-409.
DOI Scopus25 WoS22 Europe PMC18
2012 Alias, E., Dharmapatni, A., Holding, C., Atkins, G., Findlay, D., Howie, D., . . . Haynes, D. (2012). Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro. Acta Biomaterialia, 8(8), 3104-3112.
DOI Scopus21 WoS19 Europe PMC20
2012 Upton, A., Holding, C., Dharmapatni, A., & Haynes, D. (2012). The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatology International, 32(2), 535-540.
DOI Scopus46 WoS45 Europe PMC40
2011 Dharmapatni, A., Smith, M., Crotti, T., Holding, C., Vincent, C., Weedon, H., . . . Haynes, D. (2011). TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Research & Therapy, 13(2), R51-1-R51-10.
DOI Scopus40 WoS37 Europe PMC35
2010 Megson, E., Fitzsimmons, T., Dharmapatni, A., & Bartold, P. (2010). C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation. Journal of Clinical Periodontology, 37(9), 797-804.
DOI Scopus71 WoS64 Europe PMC52
2010 Kataria, N., Bartold, P., Dharmapatni, A., Atkins, G., Holding, C., & Haynes, D. (2010). Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis. Journal of Periodontal Research, 45(4), 564-573.
DOI Scopus22 WoS22 Europe PMC17
2010 Lucas, H., Bartold, P., Dharmapatni, A., Holding, C., & Haynes, D. (2010). Inhibition of apoptosis in periodontitis. Journal of Dental Research, 89(1), 29-33.
DOI Scopus50 WoS46 Europe PMC42
2009 Dharmapatni, A., Smith, M., Findlay, D., Holding, C., Evdokiou, A., Ahern, M., . . . Haynes, D. (2009). Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. Arthritis Research & Therapy, 11(1), R13:1-R13:11.
DOI Scopus54 WoS57 Europe PMC53
2006 Holding, C., Findlay, D., Stamenkov, R., Neale, S., Lucas, H., Dharmapatni, A., . . . Haynes, D. (2006). The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants. Biomaterials, 27(30), 5212-5219.
DOI Scopus116 WoS107 Europe PMC93
2005 Walker, J., Stirling, J., Beroukas, D., Dharmapatni, A., Haynes, D., Smith, M., . . . Roberts-Thomson, P. (2005). Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis. Pathology, 37(3), 220-225.
DOI Scopus31 WoS27 Europe PMC18
2001 Roberts-Thomson, P. J., Jones, M., Hakendorf, P., Kencana Dharmapatni, A. A., Walker, J. G., MacFarlane, J. G., . . . Ahern, M. J. (2001). Scleroderma in South Australia: epidemiological observations of possible pathogenic significance.. Internal medicine journal, 31(4), 220-229.
DOI Europe PMC71

Year Citation
2011 Crotti, T. N., Zawawi, M. S., Dharmapatni, A. A., Cantley, M. D., & Haynes, D. R. (2011). INHIBITION OF ITAM ADAPTOR MOLECULES AND THEIR RECEPTORS BY INHIBITION OF CALCINEURIN-NFAT SIGNALLING DURING LATE STAGE HUMAN OSTEOCLAST DIFFERENTIATION. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Dharmapatni, A. A. S., Gillard, J. W., Rainsford, K. D., & Haynes, D. R. (2011). REGULATION OF HUMAN OSTEOCLAST ACTIVITY AND APOPTOSIS BY IAP INHIBITORS IN VITRO. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603-S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2005 Dharmapatni, A. A. S. S. K., Findlay, D. M., Smith, M. D., Evdokiou, A., Chen, P., Screaton, G. R., . . . Haynes, D. R. (2005). Regulating the sensitivity of synovial fibroblasts to trail-induced apoptosis. In ANNALS OF THE RHEUMATIC DISEASES Vol. 64 (pp. 154). Vienna, AUSTRIA: BMJ PUBLISHING GROUP.

Year Citation
2016 Crotti, T. N., Coleman, R., Dharmapatni, A. A., Weedon, H., Haynes, D. R., Smith, M. D., & Wechalekar, M. D. (2016). EXPRESSION OF OSCAR IN THE SYNOVIUM OF EARLY RA PATIENTS. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP.
DOI
2014 Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2014). THE X-LINKED INHIBITORY OF APOPTOSIS PROTEIN INHIBITOR, EMBELIN SUPPRESSES INFLAMMATION AND BONE EROSION IN COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA) MICE. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
Date Project title Investigators Funding Body Amount
2016 Role of autophagy and apoptosis in the pathogenesis of inflammation and bone erosion in Chronic Periodontitis A Dharmapatni, D Haynes, M Barthold, T Crotti Australian Dental Research Foundation 17,390
2016 Pharmacologic Modulation of autophagy and apoptosis in Collagen Antibody Induced Arthritis model A Dharmapatni, T Crotti, D Haynes Arthritis Australia State/Territory Affiliate Arthritis SA 25,000
2015 Abrogating bone loss and inflammation in a mouse model of inflammatory arthritis T Crotti, A Dharmapatani, R Gibson, E Perilli Arthritis Australia Marion A Simpson Grant 25,000
2015 OSCAR A Serum Marker of Joint Erosion Enabling Treatment Modification T Crotti, A Dharmapatani, M Smith, M Wechalekar American Society for Bone and Mineral Research 50,000 USD
2014 Inhibiting autophagy to allow apoptosis to prevent joint damage in Rheumatoid Arthritis A Dharmapatani Arthritis Australia 10,000
2012 Investigating the potential use of IAP inhibitors for treatments of rheumatoid arthritis A Dharmapatani Arthritis Australia 15,000
2012 The Role of RUNX2 and VEGF during healing of periodontal ligament following hypothermal insult A Dharmapatani (CIC) Australian Dental Research Foundation 5,000
2010 Expression of Rheumatoid factor citrullinated protein and anti-citrullinated protein antibodies in normal and inflamed gingival tissue A Dharmapatani (CID) Australian Dental Research Foundation 5,000

2016 -           Lecturer Discipline of Anatomy and Pathology School of Medicine, Faculty of Health Sciences, The University of Adelaide

2014 - 2015 Tutor for Small Group discovery Experience (SGDE) part of Biology of Disease 2 (BOD2) for Bachelor of Health sciences

2009 -          Tutor for Dental and Clinical Science and Practice (DSP1 and 2) topics for 1st and 2nd year for Dentistry students at the University of Adelaide

2007 -          Guest lecturer of Biology of Human Disease (BOD2) with topic: “Bone and joint diseases” and “Infections in the developing countries”

2015            Guest lecturer for ENGR 7702, School of Computer Science, Engineering and Mathematics

2013 - 2014 Tutor for Human Biology, Anatomy and Physiology (Human Biology 1B) for Bachelor of Health Sciences

2007 - 2013 Demonstrator for Resource Sessions (integrated medical sciences including gross anatomy, histology and pathology) for 1st and 3rd year for Medicine students at the University of Adelaide

2010            Demonstrator for NURS 1102 (Anatomy and Physiology for Nursing) topic within the Nursing School at Flinders University

1996 - 2000 Lecturer Clinical Pathology for fifth semester/3rd year in the Faculty of Medicine at Udayana University, Bali, Indonesia

1996 - 2000 Lecturer Clinical Pathology for Bachelor of Nursing students at Udayana University, Bali Indonesia

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2019 Co-Supervisor Pharmacological Modulation of Inflammation, Bone Loss and Pain in a Murine Model of Inflammatory Arthritis Doctor of Philosophy Doctorate Full Time Dr Bonnie Williams
2013 - 2015 Co-Supervisor An investigation into the role of RANKL and sclerostin in dentoalveolar ankylosis using a rat model Doctor of Clinical Dentistry Doctorate Full Time Dr Shelley Joanne Coburn
2011 - 2015 Co-Supervisor Targeting NF-kappaB and NFATc1 signalling to inhibit bone resorption in peri-prosthetic osteolysis Doctor of Philosophy Doctorate Full Time Mr Muhamad Syahrul Fitri Zawawi
2010 - 2014 Co-Supervisor Osteoclast-associated Intracellular ITAM Signalling Molecules in Human Peri-implant Osteolysis and Rheumatoid Arthritis Doctor of Philosophy Doctorate Full Time Mr Ekram Alias
2010 - 2011 Co-Supervisor The Role of the Osteocyte in Orthodontic Tooth Movement in the Rat Dento-Alveolar Complex Doctor of Clinical Dentistry Doctorate Full Time Dr Dinesh Sanmuganathan
2010 - 2012 External Supervisor Insight into the Role of Periodontal Ligament Associated Protein 1 Asporin in the Maintenance of the Periodontal Ligament Using a Rat Ankylosis Model Doctor of Clinical Dentistry Doctorate Full Time Dr Wayne Chuo-Wei Chen
2010 - 2013 Co-Supervisor Expression of Runt Related Transcription Factor 2 and Vascular Endothelial Growth Factor in the Pulp, Periodontal Ligament and Alveolar Bone: An Immunohistochemical Study Using a Rat Ankylotic Model Doctor of Clinical Dentistry Doctorate Full Time Dr Trudy Ann Stewart

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