Dr Catherine Toben
Dr Catherine Toben
University of Adelaide , Discipline of Psychiatry.
My current research focus is investigating the bidirectional communication between the neuroimmune and endocrine systems underlying neuropsychiatric disorders such as schizophrenia, PTSD and major depressive disorder. With a background in immunology my research interest lies in the cellular and molecular mechanisms of the innate and adaptive immune arms. I am particularly interested in understanding the regulatory roles of monocytes/macrophages and T cell interactions including cytokine/chemokine profiles at either the cellular or transcriptomic level. In addition to empirical data being derived from clinical cohorts, animal models of chronic stress are also being utilised to gain a better understanding into the cellular and genomic alterations underlying affective disorders.
|2018||Culverhouse, R., Saccone, N., Horton, A., Ma, Y., Anstey, K., Banaschewski, T. ... Coffey, C. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular psychiatry, 23, 1, 133-142.
|2016||Hagstrom, A., Marshall, P., Lonsdale, C., Papalia, S., Cheema, B., Toben, C. ... Green, S. (2016). The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial. Breast Cancer Research and Treatment, 155, 3, 471-482.
|2015||Toben, C. & Baune, B. (2015). An act of balance between adaptive and maladaptive immunity in depression: a role for T lymphocytes. Journal of Neuroimmune Pharmacology, 10, 4, 595-609.
|2015||Jaehne, E., Corrigan, F., Toben, C., Jawahar, M. & Baune, B. (2015). The effect of the antipsychotic drug quetiapine and its metabolite norquetiapine on acute inflammation, memory and anhedonia. Pharmacology, Biochemistry, and Behavior, 135, 136-144.
|2014||Grundy, T., Toben, C., Jaehne, E., Corrigan, F. & Baune, B. (2014). Long-term omega-3 supplementation modulates behavior, hippocampal fatty acid concentration, neuronal progenitor proliferation and central TNF-alpha expression in 7 month old unchallenged mice. Frontiers in Cellular Neuroscience, 8, 399-1-399-13.
|2014||Singhal, G., Jaehne, E. J., Corrigan, F., Toben, C. & Baune, B. T. (2014). Inflammasomes in neuroinflammation and changes in brain function: a focused review. Frontiers in Neuroscience, 8, 315-1-315-22.
|2013||Ried, K., Toben, C. & Fakler, P. (2013). Effect of garlic on serum lipids: an updated meta-analysis. Nutrition Reviews, 71, 5, 282-299.
|2013||Stacey, D., Cohen-Woods, S., Toben, C., Arolt, V., Dannlowski, U. & Baune, B. (2013). Evidence of increased risk for major depressive disorder in individuals homozygous for the high-expressing 5-HTTLPR/rs25531 (LA) allele of the serotonin transporter promoter. Psychiatric Genetics, 23, 5, 222-223.
|2008||Na, S., Cao, Y., Toben, C., Nitschke, L., Stadelmann, C., Gold, R. ... Hunig, T. (2008). Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system. Brain, 131, 9, 2353-2365.
|2006||Cao, Y., Toben, C., Na, S. -. Y., Stark, K., Nitschke, L., Peterson, A. ... Hünig, T. (2006). Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes. European Journal of Immunology, 36, 1, 207-215.
|2015||Jawahar, M. C., Toben, C., Izzo, J., Heriot, N., Harrison, E., Murgatroyd, C. & Baune, B. T. (2015). The two-hit stress model: effect of early life stress and later life stressors on adult psychiatric disorders. Society for Mental Health Research (SMHR) 2015. Brisbane.|
|2015||Jawahar, M. C., Toben, C., Izzo, J., Heriot, N., Harrison, E., Murgatroyd, C. & Baune, B. T. (2015). The two-hit stress model:effect of early life stress and later life stressors on adult psychiatric disorders. Society for Mental Health Research 2015. Brisbane.|
Royal Adelaide Hospital (RAH) Research Funds: Clinical Project research grant – 2017 $44,588.00, CI-A Title: Identification of altered regulatory miRNA expression associated with altered systemic cytokine expression in a clinical cohort of patients with recurrent depression at the Royal Adelaide Hospital
Rebecca L Cooper Grant – 2015 $19,850, CI-B Title: A centralised Neuropsychiatric Biobank and Disease Marker Centre
Faculty of Health and Medical Sciences Elective Course "Fundamentals of Biological Psychiatry": topic lectures - "Pathways to neuroinflammation"; "Pathogenic roles of neuroinflammation in selected psychiatric disorders"
Faculty of Health and Medical Sciences "Scientific Basis of Medicine III Part 2": topic lecture - "Immune System and the Nervous System"
MBBS Yr6 Psychiatry Selective Coordinator
Honours Co-supervision (2013): Natalie Heriot
Honours Co-supervision (2014): Franky So
PhD Co-supervision (2016 - ): Liliana Ciobanu