Dr Catherine Toben

Catherine Toben
Lecturer
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr Catherine Toben
University of Adelaide , Discipline of Psychiatry.

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Dr Catherine Toben

Dr Catherine Toben
University of Adelaide , Discipline of Psychiatry.

My current research focus is investigating the bidirectional communication between the neuroimmune and endocrine systems underlying neuropsychiatric disorders such as schizophrenia, PTSD and major depressive disorder. With a background in immunology my research interest lies in the cellular and molecular mechanisms of the innate and adaptive immune arms. I am particularly interested in understanding the regulatory roles of monocytes/macrophages and T cell interactions including cytokine/chemokine profiles at either the cellular or transcriptomic level. In addition to empirical data being derived from clinical cohorts, animal models of chronic stress are also being utilised to gain a better understanding into the cellular and genomic alterations underlying affective disorders.

Journals

Year Citation
2018 Culverhouse, R., Saccone, N., Horton, A., Ma, Y., Anstey, K., Banaschewski, T. ... Coffey, C. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular psychiatry, 23, 1, 133-142.
10.1038/mp.2017.44
2016 Hagstrom, A., Marshall, P., Lonsdale, C., Papalia, S., Cheema, B., Toben, C. ... Green, S. (2016). The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial. Breast Cancer Research and Treatment, 155, 3, 471-482.
10.1007/s10549-016-3688-0
2015 Toben, C. & Baune, B. (2015). An act of balance between adaptive and maladaptive immunity in depression: a role for T lymphocytes. Journal of Neuroimmune Pharmacology, 10, 4, 595-609.
10.1007/s11481-015-9620-2
2015 Jaehne, E., Corrigan, F., Toben, C., Jawahar, M. & Baune, B. (2015). The effect of the antipsychotic drug quetiapine and its metabolite norquetiapine on acute inflammation, memory and anhedonia. Pharmacology, Biochemistry, and Behavior, 135, 136-144.
10.1016/j.pbb.2015.05.021
2014 Grundy, T., Toben, C., Jaehne, E., Corrigan, F. & Baune, B. (2014). Long-term omega-3 supplementation modulates behavior, hippocampal fatty acid concentration, neuronal progenitor proliferation and central TNF-alpha expression in 7 month old unchallenged mice. Frontiers in Cellular Neuroscience, 8, 399-1-399-13.
10.3389/fncel.2014.00399
2014 Singhal, G., Jaehne, E. J., Corrigan, F., Toben, C. & Baune, B. T. (2014). Inflammasomes in neuroinflammation and changes in brain function: a focused review. Frontiers in Neuroscience, 8, 315-1-315-22.
10.3389/fnins.2014.00315
2013 Ried, K., Toben, C. & Fakler, P. (2013). Effect of garlic on serum lipids: an updated meta-analysis. Nutrition Reviews, 71, 5, 282-299.
10.1111/nure.12012
2013 Stacey, D., Cohen-Woods, S., Toben, C., Arolt, V., Dannlowski, U. & Baune, B. (2013). Evidence of increased risk for major depressive disorder in individuals homozygous for the high-expressing 5-HTTLPR/rs25531 (LA) allele of the serotonin transporter promoter. Psychiatric Genetics, 23, 5, 222-223.
10.1097/YPG.0000000000000006
2008 Na, S., Cao, Y., Toben, C., Nitschke, L., Stadelmann, C., Gold, R. ... Hunig, T. (2008). Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system. Brain, 131, 9, 2353-2365.
10.1093/brain/awn148
2006 Cao, Y., Toben, C., Na, S. -. Y., Stark, K., Nitschke, L., Peterson, A. ... Hünig, T. (2006). Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes. European Journal of Immunology, 36, 1, 207-215.
10.1002/eji.200535211

Conference Items

Year Citation
2015 Jawahar, M. C., Toben, C., Izzo, J., Heriot, N., Harrison, E., Murgatroyd, C. & Baune, B. T. (2015). The two-hit stress model: effect of early life stress and later life stressors on adult psychiatric disorders. Society for Mental Health Research (SMHR) 2015. Brisbane.
2015 Jawahar, M. C., Toben, C., Izzo, J., Heriot, N., Harrison, E., Murgatroyd, C. & Baune, B. T. (2015). The two-hit stress model:effect of early life stress and later life stressors on adult psychiatric disorders. Society for Mental Health Research 2015. Brisbane.

2016:

Royal Adelaide Hospital (RAH) Research Funds: Clinical Project research grant – 2017 $44,588.00, CI-A Title: Identification of altered regulatory miRNA expression associated with altered systemic cytokine expression in a clinical cohort of patients with recurrent depression at the Royal Adelaide Hospital 

2014:

Rebecca L Cooper Grant – 2015 $19,850, CI-B Title: A centralised Neuropsychiatric Biobank and Disease Marker Centre

Undergraduate Programmes

Faculty of Health and Medical Sciences Elective Course "Fundamentals of Biological Psychiatry": topic lectures - "Pathways to neuroinflammation"; "Pathogenic roles of neuroinflammation in selected psychiatric disorders"

Faculty of Health and Medical Sciences "Scientific Basis of Medicine III Part 2": topic lecture - "Immune System and the Nervous System"

Postgraduate Programmes

MBBS Yr6 Psychiatry Selective Coordinator 

HDR Supervision 

Honours Co-supervision (2013): Natalie Heriot

Honours Co-supervision (2014): Franky So

PhD Co-supervision (2016 - ): Liliana Ciobanu

Position
Lecturer
Phone
83137318
Campus
North Terrace
Building
Adelaide Health and Medical Sciences Building
Room Number
WS7062.34
Org Unit
Medical Specialties

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