Prof Angel Lopez
Centre for Cancer Biology
College of Health
Prof Angel Lopez AO is the Head of Human Immunology at SA Pathology, CALHN, in Adelaide, holds an MD from the University of Rosario, Argentina, a PhD from the University of London, UK, and is a Fellow of the Royal College of Pathologists of Australasia. He is an experimental immunologist and haematologist with an international reputation for his work on the structure and function of cytokine receptors and their mechanism of action in health and disease.
Prof Lopez leads a team of hard working and enthusiastic investigators internationally recognized for their work into the βc cytokine family that studies how βc cytokines and their receptors assemble on the cell surface, how they signal and how they influence human health. The work of this laboratory has been highly collaborative involving several academic and clinical groups. His breakthrough discoveries revealed significant new paradigms in cytokine receptor activation that were published in major international journals. Prof Lopez’s team works closely with the pharmaceutical industry enabling the practical application of the laboratory’s insights as demonstrated by the development of several anti-receptor antibodies as potential new treatments of allergic inflammatory conditions and certain leukaemias.
The impact of Prof Lopez’s work has been recognised by his election as a Fellow of the Australian Academy of Health and Medical Science in 2014 and of the Australian Academy of Health and Medical Sciences in 2015. Prof Lopez received the 2010 South Australian Scientist of the Year Award and the 2010 South Australian of the Year - Science Category Award from the SA Government. In June 2017 he was appointed as an Officer to the Order of Australia for his medical and scientific research in the areas of immunology, cell biology and innovative developments in cancer treatment.
Prof Lopez is passionate about mentoring young researchers and promoting medical research excellence. He established (with S Kumar) the Centre for Cancer Biology in 2009 which is a member of the Australian Association of Medical Research Institute, and in 2019 he (together with Prof M Brown and Senator Griffin) was awarded an $80m Commonwealth grant to establish the South Australian immunoGenetics Cancer Institute (SAiGENCI) in South Australia
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1981 | National Institute for Medical Research, Mill Hill, University of London | United Kingdom | PhD |
| 1975 | University of Rosario (School of Medicine) | Argentina | MB BS |
| Year | Citation |
|---|---|
| 2026 | Thompson-Peach, C. A. L., Thomas, D., Dottore, M., Lim, K., Stomski, F., Panagopoulos, R. A., . . . Tvorogov, D. (2026). Ultraprecision therapy for type 1 vs type 2 CALR+MPN by dual epitope targeting that restores ruxolitinib sensitivity. Blood, 147(14), 1611-1623. Scopus2 WoS2 Europe PMC1 |
| 2026 | Nteris, O., Verghese, E., Nguyen, Q. A., Iscaro, J., Chan, S. M. H., Yip, K. H., . . . Wang, H. (2026). Extracellular vimentin promotes neutrophil-dominant granulomatous inflammation in progressive pulmonary sarcoidosis. Clinical Science London England 1979, 140(6), 975-991. |
| 2025 | Wang, H., Tumes, D. J., Keam, S., Lim, J. W., Nguyen, Q. A., Vlahos, R., . . . Yip, K. H. (2025). βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism. Frontiers in Immunology, 16, 16 pages. |
| 2025 | Kan, W. L., Weekley, C. M., Nero, T. L., Hercus, T. R., Yip, K. H., Tumes, D. J., . . . Parker, M. W. (2025). The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities. Immunological Reviews, 329(1), e13430-1-e13430-25. Scopus3 WoS4 Europe PMC2 |
| 2025 | Wang, H., Fung, N. H., Aloe, C., Miles, M., Selemidis, S., Lopez, A. F., . . . Bozinovski, S. (2025). CD131 antagonism blocks inflammation, emphysema and fibrosis in an asthma-COPD overlap mouse model originating in early life. Respirology, 30(4), 303-316. Scopus3 WoS3 Europe PMC2 |
| 2025 | Toubia, J., Kusay, Y., Maqsood, M., Warnock, N. I., Lawrence, D. M., Bracken, C. P., . . . Schreiber, A. W. (2025). TRanscriptome ANalysis of StratifiEd CohorTs (TRANSECT) enables automated assessment of global gene regulation linked to disparate expression in user defined genes and gene sets. NAR Genomics and Bioinformatics, 7(2), lqaf041-1-lqaf041-13. Scopus1 WoS1 |
| 2025 | Wang, H., Fung, N. H., Gamell, C., Woodman, N., Chan, S., Lachapelle, P., . . . Bozinovski, S. (2025). Signalling via CD131 regulates pulmonary inflammation, alveolar cell death and emphysema in COPD. ERJ Open Research, 11(3), 01020-2024-1-01020-2024-12. Scopus2 WoS2 |
| 2025 | Expòsit, M., Abedi, M., Krishnakumar, A., Jain, S., Yu, T. -Y., Hercus, T. R., . . . Baker, D. (2025). Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.. bioRxiv. |
| 2025 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2025). Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2024 | Wang, H., Yip, K. H., Keam, S. P., Vlahos, R., Nichol, K., Wark, P., . . . Tumes, D. J. (2024). Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade. Journal of Allergy and Clinical Immunology, 153(3), 672-683.e6. Scopus11 WoS12 Europe PMC9 |
| 2024 | Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 42(2), 49-61. Scopus5 WoS6 Europe PMC3 |
| 2024 | Johan, M. Z., Pyne, N. T., Kolesnikoff, N., Poltavets, V., Esmaeili, Z., Woodcock, J. M., . . . Samuel, M. S. (2024). Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis. The Journal of Investigative Dermatology, 144(11), 2562-2573.e4. Scopus2 WoS2 Europe PMC2 |
| 2024 | Hoang, N. M., Liu, Y., Bates, P. D., Heaton, A. R., Lopez, A. F., Liu, P., . . . Rui, L. (2024). Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma. Cell Reports Medicine, 5(4), 101484. Scopus15 Europe PMC8 |
| 2024 | Lim, K., Kan, W. L., Nair, P. C., Kutyna, M., Lopez, A. F., Hercus, T., . . . Thomas, D. (2024). CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting. PLoS One, 19(9), e0310641-1-e0310641-19. Scopus2 WoS1 Europe PMC1 |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. Blood Cancer Discovery, 4(5), 352-364. Scopus21 WoS18 Europe PMC14 |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. |
| 2023 | Yip, K. H., Chao, J., Coolen, C., Pant, H., Kral, A., Smith, W., . . . Tumes, D. J. (2023). IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ. Journal of Allergy and Clinical Immunology, 152(3), 725-735. Scopus5 WoS5 Europe PMC3 |
| 2023 | Kan, W. L., Dhagat, U., Hercus, T. R., Kaufmann, K. B., Nero, T. L., Zeng, A. G. X., . . . Lopez, A. (2023). Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia. Cancer Discovery, 13(8), 1922-1947. Scopus9 WoS8 Europe PMC10 |
| 2022 | Yip, K. H., McKenzie, D., Ramshaw, H. S., Chao, J., McClure, B. J., Raquet, E., . . . Tumes, D. J. (2022). Targeting the human βc Receptor inhibits contact dermatitis in a transgenic mouse model. The Journal of Investigative Dermatology, 142(4), 1103-1113. Scopus7 WoS8 Europe PMC9 |
| 2022 | Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., . . . Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death and Disease, 13(137), 1-11. Scopus31 WoS30 Europe PMC24 |
| 2022 | Tvorogov, D., Thompson-Peach, C. A. L., Foßelteder, J., Dottore, M., Stomski, F., Onnesha, S. A., . . . Lopez, A. F. (2022). Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody. EMBO Reports, 23(4), e52904-1-e52904-12. Scopus31 WoS31 Europe PMC25 |
| 2022 | Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., . . . Vinuesa, C. G. (2022). TLR7 gain-of-function genetic variation causes human lupus. Nature, 605(7909), 349-356. Scopus465 WoS426 Europe PMC435 |
| 2022 | Fung, N. H., Wang, H., Vlahos, R., Wilson, N., Lopez, A. F., Owczarek, C. M., & Bozinovski, S. (2022). Targeting the human βc receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure. Respirology, 27(8), 617-629. Scopus11 WoS11 Europe PMC10 |
| 2022 | Pant, H., Hercus, T. R., Tumes, D. J., Yip, K. H., Parker, M. W., Owczarek, C. M., . . . Huston, D. P. (2022). Translating the biology of β common receptor-engaging cytokines into clinical medicine. Journal of Allergy and Clinical Immunology, 151(2), 324-344. Scopus16 WoS11 Europe PMC13 |
| 2021 | Begley, C. G., Ashton, M., Baell, J., Bettess, M., Brown, M. P., Carter, B., . . . Sullivan, M. (2021). Drug repurposing: misconceptions, challenges, and opportunities for academic researchers. Sci Transl Med, 13(612), 1-13. Scopus118 WoS97 Europe PMC88 |
| 2021 | El Khawanky, N., Hughes, A., Yu, W., Myburgh, R., Matschulla, T., Taromi, S., . . . Zeiser, R. (2021). Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia. Nat Commun, 12(1), 6436-1-6436-20. Scopus95 WoS91 Europe PMC90 |
| 2021 | Kan, W. L., Cheung Tung Shing, K. S., Nero, T. L., Hercus, T. R., Tvorogov, D., Parker, M. W., & Lopez, A. F. (2021). Messing with βc: a unique receptor with many goals. Seminars in Immunology, 54(101513), 101513-1-101513-14. Scopus4 WoS4 Europe PMC4 |
| 2021 | De Silva, A. P., Schembri, M. A., Sarah, A. H., Chao, J., Yip, K. H., Cildir, G., . . . Pant, H. (2021). Short-term oral steroids significantly improves chronic rhinosinusitis without nasal polyps. Laryngoscope, 131(10), E2618-E2626. Scopus8 WoS8 Europe PMC5 |
| 2021 | Cildir, G., Yip, K. H., Pant, H., Tergaonkar, V., Lopez, A. F., & Tumes, D. J. (2021). Understanding mast cell heterogeneity at single cell resolution. Trends in Immunology, 42(6), 523-535. Scopus35 WoS32 Europe PMC31 |
| 2020 | Yip, K. H., Wilson, N. J., Pant, H., Brown, C. L., Busfield, S., Ng, M., . . . Owczarek, C. M. (2020). Anti-βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model. Allergy, 75(2), 475-478. Scopus10 WoS9 Europe PMC9 |
| 2020 | Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895. Scopus62 WoS62 Europe PMC57 |
| 2020 | Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908. Scopus5 WoS4 Europe PMC6 |
| 2020 | Baroni, M. L., Sanchez Martinez, D., Gutierrez Aguera, F., Roca Ho, H., Castella, M., Zanetti, S., . . . Menendez, P. (2020). 41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo. Journal for ImmunoTherapy of Cancer, 8(1), 11 pages. Scopus59 WoS59 Europe PMC56 |
| 2020 | Diallo, K., Dussault, S., Noll, C., Lopez, A. F., Rivard, A., Carpentier, A. C., & Lim, G. E. (2020). 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Molecular Metabolism, 41(101052), 1-12. Scopus4 Europe PMC7 |
| 2019 | Cheung Tung Shing, K., Broughton, S., Nero, T., Gillinder, K., Ilsley, M., Ramshaw, H., . . . Dhagat, U. (2019). Author Correction: EPO does not promote interaction between the erythropoietin and beta-common receptors (Scientific Reports, (2018), 8, 1, (12457), 10.1038/s41598-018-29865-x). Scientific Reports, 9(1), 7851. |
| 2019 | Cañete, P. F., Sweet, R. A., Gonzalez-Figueroa, P., Papa, I., Ohkura, N., Bolton, H., . . . Vinuesa, C. G. (2019). Regulatory roles of IL-10-producing human follicular T cells. The Journal of Experimental Medicine, 216(8), 1843-1856. Scopus80 WoS70 Europe PMC70 |
| 2019 | Cildir, G., Toubia, J., Yip, K. H., Zhou, M., Pant, H., Hissaria, P., . . . Tergaonkar, V. (2019). Genome-wide analyses of chromatin state in human mast cells reveal molecular drivers and mediators of allergic and inflammatory diseases. Immunity, 51(5), 949-965. Scopus49 WoS49 Europe PMC50 |
| 2019 | Gartlan, K. H., Koyama, M., Lineburg, K. E., Chang, K., Ensbey, K. S., Kuns, R. D., . . . Hill, G. R. (2019). Donor T-cell-derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract. Blood advances, 3(19), 2859-2865. Scopus21 WoS22 Europe PMC20 |
| 2018 | Hercus, T., Kan, W., Broughton, S., Tvorogov, D., Ramshaw, H., Sandow, J., . . . Lopez, A. (2018). Role of the β common (βc) family of cytokines in health and disease. Cold Spring Harbor Perspectives in Biology, 10(6), a028514. Scopus42 WoS34 Europe PMC32 |
| 2018 | Woodcock, J., Goodwin, K., Sandow, J., Coolen, C., Perugini, M., Webb, A., . . . Carver, J. (2018). Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity. Journal of Biological Chemistry, 293(1), 89-99. Scopus23 WoS23 Europe PMC20 |
| 2018 | Tvorogov, D., Thomas, D., Liau, N. P. D., Dottore, M., Barry, E. F., Lathi, M., . . . Lopez, A. F. (2018). Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis. Science Advances, 4(11), 1-12. Scopus53 WoS53 Europe PMC52 |
| 2018 | Cheung Tung Shing, K. S., Broughton, S. E., Nero, T. L., Gillinder, K., Ilsley, M. D., Ramshaw, H., . . . Dhagat, U. (2018). EPO does not promote interaction between the erythropoietin and beta-common receptors. Scientific Reports, 8(1), 12457-1-12457-16. Scopus26 WoS25 Europe PMC25 |
| 2018 | Dhagat, U., Hercus, T. R., Broughton, S. E., Nero, T. L., Cheung Tung Shing, K. S., Barry, E. F., . . . Parker, M. W. (2018). The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. mAbs, 10(7), 1018-1029. Scopus11 WoS12 Europe PMC9 |
| 2018 | Broughton, S., Hercus, T., Nero, T., Kan, W., Barry, E., Dottore, M., . . . Parker, M. (2018). A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nature Communications, 9(1), 386-1-386-15. Scopus35 WoS34 Europe PMC30 |
| 2018 | Paquette, M., Beaudoin, S., Tremblay, M. A., Jean, S., Lopez, A. F., Lecomte, R., . . . Leyton, J. V. (2018). NLS-cholic acid conjugation to IL-5Rα-specific antibody improves cellular accumulation and in vivo tumor-targeting properties in a bladder cancer model. Bioconjugate chemistry, 29(4), 1352-1363. Scopus10 WoS11 Europe PMC11 |
| 2017 | Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., . . . Jackson, S. (2017). Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature communications, 8(1), 16125. Scopus1 WoS1 |
| 2017 | Wittwer, N. L., Brumatti, G., Marchant, C., Sandow, J. J., Pudney, M. K., Dottore, M., . . . Ramshaw, H. S. (2017). High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression. Blood Advances, 1(15), 1067-1079. Scopus33 WoS31 Europe PMC28 |
| 2017 | Cildir, G., Pant, H., Lopez, A., & Tergaonkar, V. (2017). The transcriptional program, functional heterogeneity, and clinical targeting of mast cells. Journal of Experimental Medicine, 214(9), 2491-2506. Scopus86 WoS82 Europe PMC79 |
| 2017 | Paquette, M., Vilera Perez, L. G., Beaudoin, S., Ekindi Ndongo, N., Boudreaut, P. L., Bonin, M. A., . . . Leyton, J. V. (2017). Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. OncoImmunology, 6(10, article no. e1331195), 1-11. Scopus17 WoS17 Europe PMC17 |
| 2017 | Powell, J., Lewis, A., Zhu, W., Toubia, J., Pitman, M., Wallington-Beddoe, C., . . . Pitson, S. (2017). Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.. Blood, 129(6), 771-782. Scopus88 WoS80 Europe PMC77 |
| 2017 | Hughes, A. E., Clarson, J., Gargett, T., Yu, W., Brown, M. P., Lopez, A. F., . . . Yong, A. S. M. (2017). Comment on 'KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study'. Leukemia research, 55, 55-57. Scopus3 WoS3 Europe PMC3 |
| 2017 | Ng, Y., Sorvina, A., Bader, C., Weiland, F., Lopez, A., Hoffmann, P., . . . Brooks, D. (2017). Proteome analysis of Drosophila mutants identifies a regulatory role for 14-3-3ε in metabolic pathways. Journal of Proteome Research, 16(5), 1976-1987. Scopus1 WoS1 Europe PMC1 |
| 2016 | Gargett, T., Christo, S. N., Hercus, T. R., Abbas, N., Singhal, N., Lopez, A. F., & Brown, M. P. (2016). GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 5(12), 12 pages. Scopus41 WoS34 Europe PMC29 |
| 2016 | Yip, K., Kolesnikoff, N., Hauschild, N., Biggs, L., Lopez, A., Galli, S., . . . Grimbaldeston, M. (2016). The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nature Communications, 7(article no. 13198), 13198-1-13198-14. Scopus35 WoS35 Europe PMC29 |
| 2016 | Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., . . . Jackson, S. P. (2016). 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7(12862), 12862-1-12862-15. Scopus57 WoS55 Europe PMC51 |
| 2016 | Nievergall, E., Reynolds, J., Kok, C., Watkins, D., Biondo, M., Busfield, S., . . . White, D. (2016). TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy. Leukemia, 30(6), 1263-1272. Scopus50 WoS45 Europe PMC38 |
| 2016 | Vu, T., Austin, R., Kuhn, C. P., Bruedigam, C., Song, A., Guignes, S., . . . Lane, S. W. (2016). Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling. Haematologica, 101(3), e77-e80. Scopus5 WoS5 Europe PMC5 |
| 2016 | Lim, G. E., Piske, M., Lulo, J. E., Ramshaw, H. S., Lopez, A. F., & Johnson, J. D. (2016). Ywhaz/14-3-3ζ deletion improves glucose tolerance through a GLP-1-dependent mechanism. Endocrinology, 157(7), 2649-2659. Scopus27 WoS27 Europe PMC25 |
| 2016 | Ebert, L. M., Tan, L. Y., Johan, M. Z., Min, K. K. M., Cockshell, M. P., Parham, K. A., . . . Bonder, C. S. (2016). A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis. Angiogenesis, 19(4), 463-486. Scopus43 WoS44 Europe PMC36 |
| 2016 | Broughton, S. E., Hercus, T. R., Nero, T. L., King-Scott, J., Lopez, A. F., Parker, M. W., . . . Gorman, M. A. (2016). Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. Structure, 24(8), 1271-1281. Scopus47 WoS45 Europe PMC39 |
| 2016 | Panousis, C., Dhagat, U., Edwards, K. M., Rayzman, V., Hardy, M. P., Braley, H., . . . Owczarek, C. M. (2016). CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. mAbs, 8(3), 436-453. Scopus43 WoS36 Europe PMC33 |
| 2015 | Broughton, S. E., Nero, T. L., Dhagat, U., Kan, W. L., Hercus, T. R., Tvorogov, D., . . . Parker, M. W. (2015). The βc receptor family - Structural insights and their functional implications. Cytokine, 74(2), 247-258. Scopus70 WoS62 Europe PMC56 |
| 2015 | Lee, E., Yee, D., Busfield, S., McManus, J., Cummings, N., Vairo, G., . . . Lock, R. (2015). Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice. Haematologica, 100(7), 914-926. Scopus60 WoS53 Europe PMC51 |
| 2015 | Moldenhauer, L., Cockshell, M., Frost, L., Parham, K., Tvorogov, D., Tan, L., . . . Bonder, C. (2015). Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties. Stem Cell Research, 14(3), 380-395. Scopus18 WoS19 Europe PMC15 |
| 2015 | Woodcock, J., Coolen, C., Goodwin, K., Baek, D., Bittman, R., Samuel, M., . . . Lopez, A. (2015). Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics. Oncotarget, 6(16), 14522-14536. Scopus35 WoS31 Europe PMC27 |
| 2015 | He, S., Busfield, S., Ritchie, D., Hertzberg, M., Durrant, S., Lewis, I., . . . Roberts, A. (2015). A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia. Leukemia & Lymphoma, 56(5), 1406-1415. Scopus109 WoS105 Europe PMC99 |
| 2015 | Xu, X., Jaehne, E., Greenberg, Z., McCarthy, P., Saleh, E., Parish, C., . . . Schwarz, Q. (2015). 14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders. Scientific Reports, 5(12434), 12434-1-12434-15. Scopus40 WoS38 Europe PMC37 |
| 2015 | Lim, G., Albrecht, T., Piske, M., Sarai, K., Lee, J., Ramshaw, H., . . . Johnson, J. (2015). 14-3-3ζ coordinates adipogenesis of visceral fat. Nature Communications, 6(7671), 7671-1-7671-17. Scopus59 WoS58 Europe PMC60 |
| 2015 | Jaehne, E., Ramshaw, H., Xu, X., Saleh, E., Clark, S., Schubert, K., . . . Baune, B. (2015). In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders. Pharmacology Biochemistry and Behavior, 138, 1-8. Scopus13 WoS12 Europe PMC11 |
| 2015 | Kular, J., Scheer, K., Pyne, N., Allam, A., Pollard, A., Magenau, A., . . . Samuel, M. (2015). A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis. Developmental Cell, 35(6), 759-774. Scopus32 WoS26 Europe PMC32 |
| 2014 | Toyo-oka, K., Wachi, T., Hunt, R. F., Baraban, S. C., Taya, S., Ramshaw, H., . . . Wynshaw-Boris, A. (2014). 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. The Journal of Neuroscience, 34(36), 12168-12181. Scopus99 WoS100 Europe PMC98 |
| 2014 | Yip, K., Kolesnikoff, N., Yu, C., Hauschild, N., Taing, H., Biggs, L., . . . Grimbaldeston, M. (2014). Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation. Journal of Allergy and Clinical Immunology, 133(5), 1356-1379. Scopus105 WoS92 Europe PMC83 |
| 2014 | Hercus, T., Broughton, S., Hardy, M., Nero, T., Wilson, N., Parker, M., & Lopez, A. (2014). Unexpected mechanisms of action for a cytokine receptor-blocking antibody.. Molecular & cellular oncology, 1(4), e969129. Scopus1 WoS1 Europe PMC1 |
| 2014 | Broughton, S., Hercus, T., Hardy, M., McClure, B., Nero, T., Dottore, M., . . . Lopez, A. (2014). Dual mechanism of Interleukin-3 receptor blockade by an anti-cancer antibody. Cell Reports, 8(2), 410-419. Scopus54 WoS47 Europe PMC41 |
| 2014 | Broughton, S., Hercus, T., Nero, T., Dhagat, U., Owczarek, C., Hardy, M., . . . Parker, M. (2014). Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362. Acta Crystallographica Section F: Structural Biology Communications, 70(3), 358-361. Scopus8 WoS8 Europe PMC6 |
| 2014 | Busfield, S., Biondo, M., Wong, M., Ramshaw, H., Lee, E., Ghosh, S., . . . Nash, A. (2014). Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC. Leukemia, 28(11), 2213-2221. Scopus127 WoS114 Europe PMC107 |
| 2014 | Sadras, T., Perugini, M., Kok, C., Iarossi, D., Heatley, S., Brumatti, G., . . . D'Andrea, R. (2014). Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia. Journal of Leukocyte Biology, 96(1), 83-91. Scopus18 WoS17 Europe PMC15 |
| 2014 | Nievergall, E., Ramshaw, H., Yong, A., Biondo, M., Busfield, S., Vairo, G., . . . Hiwase, D. (2014). Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells. Blood, 123(8), 1218-1228. Scopus91 WoS84 Europe PMC82 |
| 2013 | Ramshaw, H., Xu, X., Jaehne, E., McCarthy, P., Greenberg, Z., Saleh, E., . . . Schwarz, Q. (2013). Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction. Translational Psychiatry, 3(e327), 1-10. Scopus27 WoS26 Europe PMC24 |
| 2013 | Lim, Y., Wright, J., Attema, J., Gregory, P., Bert, A., Smith, E., . . . Goodall, G. (2013). Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. Journal of Cell Science, 126(10), 2256-2266. Scopus175 WoS161 Europe PMC153 |
| 2013 | Thomas, D., Powell, J., Green, B., Barry, E., Ma, Y., Woodcock, J., . . . Guthridge, M. (2013). Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology, 11(3), 1-14. Scopus20 WoS17 Europe PMC21 |
| 2013 | Thomas, D., Powell, J., Vergez, F., Segal, D., Nguyen, N., Baker, A., . . . Guthridge, M. (2013). Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood, 122(5), 738-748. Scopus59 WoS58 Europe PMC53 |
| 2013 | Hercus, T., Dhagat, U., Kan, W., Broughton, S., Nero, T., Perugini, M., . . . Lopez, A. (2013). Signalling by the βc family of cytokines. Cytokine & Growth Factor Reviews, 24(3), 189-201. Scopus88 WoS79 Europe PMC75 |
| 2013 | Kim, S., Karasuyama, H., Lopez, A., Ouyang, W., Li, X., Le Gros, G., & Min, B. (2013). IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses. Immune Network, 13(6), 249-256. Europe PMC9 |
| 2013 | Tettamanti, S., Marin, V., Pizzitola, I., Magnani, C., Giordano Attianese, G., Cribioli, E., . . . Biagi, E. (2013). Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. British Journal of Haematology, 161(3), 389-401. Scopus191 WoS184 Europe PMC171 |
| 2013 | Hercus, T., Barry, E., Dottore, M., McClure, B., Webb, A., Lopez, A., . . . Murphy, J. (2013). High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties. PLoS ONE, 8(8), e74376-e74376-8. Scopus16 WoS15 Europe PMC13 |
| 2012 | Appleby, S., Cockshell, M., Pippal, J., Thompson, E., Barrett, J., Tooley, K., . . . Bonder, C. (2012). Characterization of a distinct population of circulating human non-adherent endothelial forming cells and their recruitment via intercellular adhesion molecule-3. PLoS One, 7(11), 1-15. Scopus22 WoS22 Europe PMC17 |
| 2012 | Broughton, S., Dhagat, U., Hercus, T., Nero, T., Grimbaldeston, M., Bonder, C., . . . Parker, M. (2012). The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunological Reviews, 250(1), 277-302. Scopus217 WoS196 Europe PMC181 |
| 2012 | Broughton, S., Hercus, T., Lopez, A., & Parker, M. (2012). Cytokine receptor activation at the cell surface. Current Opinion in Structural Biology, 22(3), 350-359. Scopus29 WoS29 Europe PMC27 |
| 2012 | Markey, K., Koyama, M., Kuns, R., Lineburg, K., Wilson, Y., Olver, S., . . . MacDonald, K. (2012). Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets. Blood, 119(24), 5918-5930. Scopus35 WoS30 Europe PMC29 |
| 2012 | Cheah, P., Ramshaw, H., Thomas, P., Toyo-oka, K., Xu, X., Martin, S., . . . Schwarz, Q. (2012). Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency. Molecular Psychiatry, 17(4), 451-466. Scopus98 WoS94 Europe PMC96 |
| 2012 | Hercus, T., Broughton, S., Ekert, P., Ramshaw, H., Perugini, M., Grimbaldeston, M., . . . Lopez, A. (2012). The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors, 30(2), 63-75. Scopus64 WoS60 Europe PMC57 |
| 2012 | Sandow, J., Jabbour, A., Condina, M., Daunt, C., Stomski, F., Green, B., . . . Ekert, P. (2012). Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death and Differentiation, 19(4), 633-641. Scopus29 WoS25 Europe PMC26 |
| 2012 | Pitman, M., Woodcock, J., Lopez, A., & Pitson, S. (2012). Molecular targets of FTY720 (Fingolimod). Current Molecular Medicine, 12(10), 1207-1219. Scopus62 WoS59 Europe PMC57 |
| 2011 | Yu, C., Fedoric, B., Anderson, P. H., Lopez, A. F., & Grimbaldeston, M. A. (2011). Vitamin D<sub>3</sub> signalling to mast cells: A new regulatory axis. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 43(1), 41-46. WoS24 |
| 2011 | Shandala, T., Woodcock, J., Ng, Y., Biggs, L., Skoulakis, E., Brooks, D., & Lopez, A. (2011). Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity. Journal of Cell Science, 124(13), 2165-2174. Scopus44 WoS44 Europe PMC39 |
| 2011 | Yu, C., Fedoric, B., Anderson, P., Lopez, A., & Grimbaldeston, M. (2011). Vitamin D₃ signalling to mast cells: A new regulatory axis. International Journal of Biochemistry & Cell Biology, 43(1), 41-46. Scopus31 Europe PMC16 |
| 2010 | Lopez, A., Hercus, T., Ekert, P., Littler, D., Guthridge, M., Thomas, D., . . . Parker, M. (2010). Molecular basis of cytokine receptor activation. IUBMB Life, 62(7), 509-518. Scopus65 WoS58 Europe PMC49 |
| 2010 | Hiwase, D., White, D., Powell, J., Saunders, V., Zrim, S., Frede, A., . . . Hughes, T. (2010). Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors. Leukemia, 24(4), 771-778. Scopus48 WoS42 Europe PMC41 |
| 2010 | Kim, S., Prout, M., Ramshaw, H., Lopez, A., LeGros, G., & Min, B. (2010). Cutting edge: Basophils are transiently recruited into the draining lymph nodes during Helminth infection via IL-3, but infection-induced Th2 immunity can develop without Basophil lymph node recruitment or IL-3. Journal of Immunology, 184(3), 1143-1147. Scopus133 WoS118 Europe PMC113 |
| 2010 | Woodcock, J., Ma, Y., Coolen, C., Pham, D., Jones, C., Lopez, A., & Pitson, S. (2010). Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cellular Signalling, 22(9), 1291-1299. Scopus65 WoS63 Europe PMC61 |
| 2010 | Perugini, M., Brown, A., Salerno, D., Booker, G., Stojkoski, C., Hercus, T., . . . D'Andrea, R. (2010). Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit. Blood, 115(16), 3346-3353. Scopus60 WoS52 Europe PMC46 |
| 2010 | Biggs, L., Yu, C., Fedoric, B., Lopez, A., Galli, S., & Grimbaldeston, M. (2010). Evidence that vitamin D-3 promotes mast cell-dependent reduction of chronic UVB-nduced skin pathology in mice. Journal of Experimental Medicine, 207(3), 455-463. Scopus108 WoS101 Europe PMC82 |
| 2009 | Powell, J., Thomas, D., Barry, E., Kok, C., McClure, B., Tsykin, A., . . . Guthridge, M. (2009). Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. Blood, 114(23), 4859-4870. Scopus53 WoS51 Europe PMC49 |
| 2009 | Hercus, T., Thomas, D., Guthridge, M., Ekert, P., King-Scott, J., Parker, M., & Lopez, A. (2009). The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood, 114(7), 1289-1298. Scopus271 WoS259 Europe PMC221 |
| 2009 | Jin, L., Lee, E., Ramshaw, H., Busfield, S., Peoppl, A., Wilkinson, L., . . . Lock, R. (2009). Monoclonal antibody-mediated targeting of CD123, IL-3 receptor α chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell, 5(1), 31-42. Scopus471 WoS423 Europe PMC386 |
| 2009 | Barry, E., Felquer, F., Powell, J., Biggs, L., Stomski, F., Urbani, A., . . . Guthridge, M. (2009). 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. Journal of Biological Chemistry, 284(18), 12080-12090. Scopus35 WoS32 Europe PMC29 |
| 2009 | Jabbour, A., Heraud, J., Daunt, C., Kaufmann, T., Sandow, J., O'Reilly, L., . . . Ekert, P. (2009). Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death and Differentiation, 16(4), 555-563. Scopus72 WoS70 Europe PMC64 |
| 2009 | Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., . . . Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. Scopus39 WoS37 Europe PMC34 |
| 2008 | Hansen, G., Hercus, T., Mc Clure, B., Stomski, F., Dottore, M., Powell, J., . . . Parker, M. (2008). The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell, 134(3), 496-507. Scopus278 WoS256 Europe PMC228 |
| 2008 | Hansen, G., Hercus, T., Xu, Y., Lopez, A., Parker, M., & McKinstry, W. (2008). Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 64(Part 8), 711-714. Scopus8 WoS5 Europe PMC3 |
| 2008 | Mu, F., Andrews, R., Arthur, J., Munday, A., Cranmer, S., Jackson, S., . . . Berndt, M. (2008). A functional 14-3-3ζ-independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Blood, 111(9), 4580-4587. Scopus43 WoS37 Europe PMC33 |
| 2008 | Asquith, K., Ramshaw, H., Hansbro, P., Beagley, K., Lopez, A., & Foster, P. (2008). The IL-3/IL-5/GM-CSF common beta receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. Journal of Immunology, 180(2), 1199-1206. Scopus112 WoS108 Europe PMC92 |
| 2007 | Ramshaw, H., Guthridge, M., Stomski, F., Barry, E., Ooms, L., Mitchell, C., . . . Lopez, A. (2007). The Shc-binding site of the β[c] subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood, 110(10), 3582-3590. Scopus21 WoS19 Europe PMC15 |
| 2007 | Guthridge, M. A., & Lopez, A. F. (2007). Phosphotyrosine/phosphoserine binary switches: A new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?. Biochemical Society Transactions, 35(2), 250-252. Scopus9 WoS9 Europe PMC9 |
| 2006 | Holland, J., Kochetkova, M., Akekawatchai, C., Dottore, M., Lopez, A., & McColl, S. (2006). Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells. Cancer Research, 66(8), 4117-4124. Scopus85 WoS83 Europe PMC80 |
| 2006 | Guthridge, M., Powell, J., Barry, E., Stomski, F., Mc Clure, B., Ramshaw, H., . . . Lopez, A. (2006). Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. EMBO Journal, 25(3), 479-489. Scopus74 WoS73 Europe PMC70 |
| 2005 | Ma, Y., Pitson, S., Hercus, T., Murphy, J., Lopez, A., & Woodcock, J. (2005). Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. Journal of Biological Chemistry, 280(28), 26011-26017. Scopus67 WoS62 Europe PMC52 |
| 2004 | Guthridge, M., Barry, E., Felquer, F., Mc Clure, B., Stomski, F., Ramshaw, H., & Lopez, A. (2004). The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kB and induction of bcl-2. Blood, 103(3), 820-827. Scopus68 WoS64 Europe PMC57 |
| 2004 | Thomas, D., Vadas, M., & Lopez, A. (2004). Regulation of haematopoiesis by growth factors - emerging insights and therapies. Expert Opinion on Biological Therapy, 4(6), 869-879. Scopus17 WoS16 Europe PMC17 |
| 2003 | Mc Clure, B., Hercus, T., Cambareri, B., Woodcock, J., Bagley, C., Howlett, G., & Lopez, A. (2003). Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex. Blood, 101(4), 1308-1315. Scopus38 WoS34 Europe PMC30 |
| 2003 | Olayioye, M., Guthridge, M., Stomski, F., Lopez, A., Visvader, J., & Lindeman, G. (2003). Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins. Journal of Biological Chemistry, 278(35), 32929-32935. Scopus25 WoS23 Europe PMC20 |
| 2003 | Woodcock, J., Murphy, J., Stomski, F., Berndt, M., & Lopez, A. (2003). The dimeric versus monomeric status of 14-3-3z is controlled by phosphorylation of Ser58 at the dimer interface. Journal of Biological Chemistry, 278(38), 36323-36327. Scopus161 WoS153 Europe PMC153 |
| 2002 | Ramshaw, H., Lopez, A., & Bardy, P. (2002). The development of cytokine receptor antagonists as potential therapeutic agents for the myeloproliferative disorders. Current Pharmaceutical Design, 8(5), 357-368. Scopus1 Europe PMC1 |
| 2002 | Ramshaw, H., Bardy, P., Lee, M., & Lopez, A. (2002). Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. Experimental Hematology, 30(10), 1124-1131. Scopus41 WoS38 Europe PMC35 |
| 2002 | Olver, I., Hercus, T., Lopez, A., Vadas, M., Somogyi, A., Doyle, I., . . . Wigley, P. (2002). A phase I study of the GM-CSF antagonist E21R. Cancer Chemotherapy and Pharmacology, 50(3), 171-178. Scopus8 WoS8 Europe PMC7 |
| 2001 | Mc Clure, B., Stomski, F., Lopez, A., & Woodcock, J. (2001). Perverted responses of the human granulocyte-macrophage colony-stimulating factor receptor in mouse cell lines due to cross-species b-subunit association. Blood, 98(10), 3165-3168. Scopus6 WoS6 Europe PMC6 |
| 2001 | Bagley, C., Woodcock, J., Guthridge, M., Stomski, F., & Lopez, A. (2001). Structural and functional hot spots in cytokine receptors. International Journal of Hematology, 73(3), 299-307. Scopus10 WoS8 Europe PMC7 |
| 2001 | Mc Clure, B., Woodcock, J., Harrison-Findik, D., Lopez, A., & D'Andrea, R. (2001). GM-CSF binding to its receptor induces oligomerisation of the common beta-subunit. Cytokine, 13(4), 240-243. Scopus6 WoS6 Europe PMC5 |
| 2001 | Ramshaw, H. S., Woodcock, J. M., McClure, B. J., Hercus, T. R., Lopez, A. F., & Bagley, C. J. (2001). New approaches in the treatment of asthma. Immunology and Cell Biology, 79(2), 154-159. Scopus29 WoS26 Europe PMC20 |
| 2000 | Le, F., Stomski, F., Woodcock, J., Lopez, A., & Gonda, T. (2000). The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity. Journal of Biological Chemistry, 275(7), 5124-5130. Scopus22 WoS19 Europe PMC17 |
| 2000 | Guthridge, M., Stomski, F., Barry, E., Winnall, W., Woodcock, J., Mc Clure, B., . . . Lopez, A. (2000). Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. Molecular Cell, 6(1), 99-108. Scopus72 WoS68 Europe PMC61 |
| 2000 | Rossjohn, J., McKinstry, W., Woodcock, J., Mc Clure, B., Hercus, T., Parker, M., . . . Bagley, C. (2000). Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common b-chain bound to an antagonist. Blood, 95(8), 2491-2498. Scopus51 WoS45 Europe PMC40 |
| 2000 | Mulhern, T., Lopez, A., D'Andrea, R., Gaunt, C., Vandeleur, L., Vadas, M., . . . Bagley, C. (2000). The solution structure of the cytokine-binding domain of the common -chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. Journal of Molecular Biology, 297(4), 989-1001. Scopus26 WoS26 Europe PMC21 |
| 2000 | Stomski, F. C., Guthridge, M. A., Barry, E. F., Winnall, W., Woodcock, J. M., Lopez, A. F., & Ramshaw, H. (2000). Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. EXPERIMENTAL HEMATOLOGY, 28(7), 119. |
| 2000 | Kedzierska, K., Maerz, A., Warby, T., Jaworowski, A., Chan, H. T., Mak, J., . . . Crowe, S. (2000). Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages. AIDS, 14(12), 1739-1748. Scopus54 WoS46 Europe PMC41 |
| 2000 | Kedzierska, K., Mak, J., Mijch, A., Cooke, I., Rainbird, M., Roberts, S., . . . Crowe, S. M. (2000). Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1- infected monocytes/macrophages in vitro and in vivo. Journal of Infectious Diseases, 181(1), 390-394. Scopus67 WoS60 Europe PMC46 |
| 1999 | Ramshaw, H. S., Bardy, P., & Lopez, A. F. (1999). Role of E21R, a specific GM-CSF antagonist, on chronic myelomonocytic leukaemia. EXPERIMENTAL HEMATOLOGY, 27(7), 82. |
| 1999 | Haman, A., Cadieux, C., Wilkes, B., Hercus, T., Lopez, A., Clark, S., & Hoang, T. (1999). Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly. Journal of Biological Chemistry, 274(48), 34155-34163. Scopus23 WoS21 Europe PMC17 |
| 1999 | Jiang, X., Lopez, A., Holyoake, T., Eaves, A., & Eaves, C. (1999). Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 96(22), 12804-12809. Scopus210 WoS198 Europe PMC174 |
| 1999 | Sun, Q., Jones, K., McClure, B., Cambareri, B., Zacharakis, B., Iversen, P., . . . Lopez, A. (1999). Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulting factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors. Blood, 94(6), 1943-1951. Scopus61 WoS52 Europe PMC28 |
| 1999 | Stomski, F., Dottore, M., Winnall, W., Guthridge, M., Woodcock, J., Bagley, C., . . . Lopez, A. (1999). Identification of a 14-3-3 binding sequence in the common B chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF. Blood, 94(6), 1933-1942. Scopus46 WoS39 Europe PMC30 |
| 1999 | Mulhern, T., Bagley, C., Gaunt, C., Lopez, A., Vadas, M., D'Andrea, R., & Booker, G. (1999). Letter to the Editor: 1H and 15N chemical shift assignments for domain 4 of the common β-chain of the IL-3, IL-5 and GM-CSF receptors. Journal of Biomolecular NMR, 14(3), 281-282. Scopus1 WoS1 Europe PMC1 |
| 1999 | Woodcock, J., Bagley, C., & Lopez, A. (1999). The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications. International Journal of Biochemistry and Cell Biology, 31(-), 1017-1025. Scopus18 WoS14 Europe PMC13 |
| 1999 | Woodcock, J., Bagley, C., & Lopez, A. (1999). The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications.. Int J Biochem Cell Biol, 31(10), 1017-1025. |
| 1998 | Guthridge, M. A., Stomski, F. C., Thomas, D., Woodcock, J. M., Bagley, C. J., Berndt, M. C., & Lopez, A. F. (1998). Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors. Stem Cells, 16(5), 301-313. Scopus159 WoS150 Europe PMC127 |
| 1998 | Stomski, F. C., Woodcock, J. M., Zacharakis, B., Bagley, C. J., Sun, Q., & Lopez, A. F. (1998). Identification of a cys motif in the common β chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors. Journal of Biological Chemistry, 273(2), 1192-1199. Scopus55 WoS50 Europe PMC43 |
| 1998 | Hoang, T., Rajotte, D., Cadieux, C., Haitian, A., Wilkes, B. C., Clark, S. C., . . . Lopez, A. (1998). Crucial role of the residue ARG280 at the F-G loop of the human GM-CSF receptor a chain for ligand recognition. Experimental Hematology, 26(8), 720. |
| 1998 | Woodcock, J., McClure, B., Zacharakis, B., Slomski, F., & Lopez, A. (1998). Determining the biological significance of the preformed GM-CSF receptor. Experimental Hematology, 26(8), 720. |
| 1998 | Kedzierska, K., Rainbird, M. A., Lopez, A. F., & Crowe, S. M. (1998). Effect of GM-CSF on HIV-1 replication in monocytes/macrophages in vivo and in vitro: A review. Veterinary Immunology and Immunopathology, 63(1-2), 111-121. Scopus18 WoS16 Europe PMC14 |
| 1998 | Ramshaw, H. S., Iversen, P., & Lopez, A. F. (1998). E21R, a human GM-CSF antagonist, eradicates engrafted leukemic cells from immunodeficient mice. Experimental Hematology, 26(8), 745. |
| 1998 | Yamada, T., Sun, Q., Zeibecoglou, K., Bungre, J., North, J., Kay, A. B., . . . Robinson, D. S. (1998). IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor α-subunit, and common β-subunit expression by peripheral leukocytes and blood dendritic cells. Journal of Allergy and Clinical Immunology, 101(5), 677-682. Scopus54 WoS50 Europe PMC36 |
| 1997 | Iversen, P. O., Lewis, I. D., Turczynowicz, S., Hasle, H., Niemeyer, C., Schmiegelow, K., . . . Lopez, A. F. (1997). Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice. Blood, 90(12), 4910-4917. Scopus51 WoS44 Europe PMC24 |
| 1997 | Murray, J., Barbara, J. A. J., Dunkley, S. A., Lopez, A. F., VanOstade, X., Condliffe, A. M., . . . Chilvers, E. R. (1997). Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. BLOOD, 90(7), 2772-2783. WoS266 Europe PMC149 |
| 1997 | Meng, Q., Ying, S., Iversen, P., Lopez, A. F., Kay, A. B., & Robinson, D. S. (1997). E21R, a mutant of human granulocyte-macrophage colony-stimulating factor (GM-CSF), selectively inhibits GM-CSF-enhanced eosinophil degranulation.. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 99(1), 497. |
| 1997 | Woodcock, J., McClure, B., Stomski, F., Baglev, C., & Lopez, A. (1997). The mechanism of GM-CSF receptor activation. Experimental Hematology, 25(8), 760. |
| 1997 | Vadas, M. A., Lopez, A. F., & Shannon, M. F. (1997). Human interleukin-3(IL-3) variants and their use to promote or antagonize IL-3-mediated processes. Biotechnology Advances, 15(3-4), 773. |
| 1997 | Woodcock, J. M., Bagley, C. J., & Lopez, A. F. (1997). Receptors of the cytokine superfamily: Mechanisms of activation and involvement in disease. Bailliere S Clinical Haematology, 10(3), 507-524. Scopus3 WoS2 Europe PMC1 |
| 1997 | Iversen, P. O., Robinson, D., Ying, S., Meng, Q., Kay, A. B., Clark-Lewis, I., & Lopez, A. F. (1997). The GM-CSF analogue E21R induces apoptosis of normal and activated eosinophils. American Journal of Respiratory and Critical Care Medicine, 156(5), 1628-1632. Scopus23 WoS18 Europe PMC11 |
| 1997 | Woodcock, J. M., McClure, B. J., Stomski, F. C., Elliott, M. J., Bagley, C. J., & Lopez, A. F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM- CSF, interleukin-3, or interleukin-5. Blood, 90(8), 3005-3017. Scopus54 WoS53 Europe PMC41 |
| 1997 | Bagley, C. J., Lopez, A. F., & Vadas, M. A. (1997). New frontiers for IL-5.. The Journal of allergy and clinical immunology, 99(6 Pt 1), 725-728. Europe PMC25 |
| 1997 | Bagley, C. J., Woodcock, J. M., Stomski, F. C., & Lopez, A. F. (1997). The structural and functional basis of cytokine receptor activation: Lessons from the common β subunit of the granulocyte-macrophage colony- stimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood, 89(5), 1471-1482. Scopus170 WoS157 Europe PMC102 |
| 1997 | Iversen, P., Hart, P., Bonder, C., & Lopez, A. (1997). Interleukin (IL)-10, but not IL-4 or IL-13, inhibits cytokine production and growth in juvenile myelomonocytic leukemic cells.. Cancer Research, 57(3), 476-480. Scopus14 WoS16 Europe PMC9 |
| 1997 | Bagley, C., Woodcock, J., Stomski, F., & Lopez, A. (1997). The structural and functional basis of cytokine receptor activation: lessons from the commonb subunit of the GM-CSF, IL-3 and IL-5 receptors.. Blood, 89, 1471-1482. |
| 1997 | Barry, S., Korpelainen, E., Sun, Q., Stomski, F., Moretti, P., Wakao, H., . . . Goodall, G. (1997). Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function.. Blood, 89(3), 842-852. Scopus56 WoS56 Europe PMC31 |
| 1997 | Murray, J., Barbara, J., Dunkley, S., Lopez, A., Van Ostade, X., Condliffe, A., . . . Chilvers, E. (1997). Regulation of neutrophil apoptosis by TNF-a: requirement for TNFR55 and TNFR75 for induction of apoptois in vitro.. Blood, 90(7), 2772-2783. Scopus287 |
| 1997 | Iversen, P., Lewis, I., Turczynowicz, S., Hasle, H., Niemeyer, C., Schmiegelow, K., . . . Lopez, A. (1997). Inhibition of GM-CSF prevents dissemination and induces remission of human juvenile myelomonocytic leukemia in engrafted immunodeficient mice.. Blood, 90(12), 4910-4917. |
| 1997 | Woodcock, J., McClure, F., Stomski, F., Elliott, M., Bagley, C., & Lopez, A. (1997). The human GM-CSF receptor exists as a preformed receptor complex that can be activated by GM-CSF, IL-3 or IL-5. Blood, 90, 3005-3017. |
| 1997 | Iversen, P., Hercus, T., Zacharakis, B., Woodcock, J., Stomski, F., Kumar, S., . . . Lopez, A. (1997). The apoptosis-inducing granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R functions through specific regions of the heterodimeric GM-CSF receptor, and requires interleukin-1 beta converting enzyme-like proteases.. Journal of Biological Chemistry, 272(15), 9877-9883. Scopus12 WoS12 Europe PMC9 |
| 1997 | Bagley, C., Lopez, A., & Vadas, M. (1997). New frontiers for IL-5. Journal of Allergy and Clinical Immunology, 99(Number 6 Part 1), 725-728. Scopus40 WoS37 |
| 1997 | Rajotte, D., Cadieux, C., Haman, A., Wilkes, B., Clark, S., Hercus, T., . . . Hoang, T. (1997). Crucial role of the residue at the F'-G' loop of the human GM-CSF receptor a chain for ligand recognition.. Journal of Experimental Medicine, 185(11), 1939-1950. Scopus31 WoS30 Europe PMC24 |
| 1997 | Kocketkova, M., Iversen, P., Lopez, A., & Shannon, M. (1997). Deoxyribo-nucleic acid triplex formation inhibits granulocyte-macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells.. Journal of Clinical Investigation, 99(12), 3000-3008. Scopus47 WoS45 Europe PMC30 |
| 1996 | Qiyu, S., Woodcock, J., Stomski, F., Bagley, C., Goodall, G., Smith, W., . . . Lopez, A. (1996). Monoclonal antibody 7G3 recognises the N-terminal domain of the human IL-3 receptor and functions as a specific IL-3 receptor antagonist. Blood, 87(1), 83-92. Scopus99 WoS97 Europe PMC66 |
| 1996 | Jenkins, B., Bagley, C., Woodcock, J., Lopez, A., & Gonda, T. (1996). Interacting residues ion the extracellular region of the common β subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation. Journal of Biological Chemistry, 271(47), 29707-29714. Scopus22 WoS22 Europe PMC21 |
| 1996 | Macardle, P., Chen, Z., Shih, C., Huang, C., Weedon, H., Sun, Q., . . . Zola, H. (1996). Characterization of human leucocytes bearing the IL-3 receptor. Cellular Immunology, 168(1), 59-68. Scopus9 WoS10 Europe PMC8 |
| 1996 | Bagley, C. J., Phillips, J., Cambareri, B., Vadas, M. A., & Lopez, A. F. (1996). A discontinuous eight-amine acid epitope in human interleukin-3 binds the α-chain of its receptor. Journal of Biological Chemistry, 271(50), 31922-31928. Scopus18 WoS18 Europe PMC12 |
| 1996 | Woodcock, J. M., Bagley, C. J., Zacharakis, B., & Lopez, A. F. (1996). A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL- 5 receptor common β-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. Journal of Biological Chemistry, 271(42), 25999-26006. Scopus87 WoS89 Europe PMC73 |
| 1996 | Iversen, P. O., Rodwell, R. L., Pitcher, L., Taylor, K. M., & Lopez, A. F. (1996). Inhibition of proliferation and induction of apoptosis in juvenile myelomonocytic leukemic cells by the granulocyte-macrophage colony- stimulating factor analogue E21R. Blood, 88(7), 2634-2639. Scopus43 WoS39 Europe PMC17 |
| 1996 | Stomski, F. C., Sun, Q., Bagley, C. J., Woodcock, J., Goodall, G., Andrews, R. K., . . . Lopez, A. F. (1996). Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor α- and β-chain heterodimerization, which is required for receptor activation but not high-affinity binding. Molecular and Cellular Biology, 16(6), 3035-3046. Scopus73 WoS71 Europe PMC53 |
| 1996 | Iversen, P. O., To, L. B., & Lopez, A. F. (1996). Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R. Proceedings of the National Academy of Sciences of the United States of America, 93(7), 2785-2789. Scopus26 WoS25 Europe PMC16 |
| 1996 | Khew-Goodall, Y., Butcher, C. M., Litwin, M. S., Newlands, S., Korpelainen, E. I., Noack, L. M., . . . Vadas, M. A. (1996). Chronic expression of P-selectin on endothelial cells stimulated by the T-Cell cytokine, interleukin-3. Blood, 87(4), 1432-1438. Scopus86 WoS77 Europe PMC51 |
| 1996 | Korpelainen, E. I., Gamble, J. R., Vadas, M. A., & Lopez, A. F. (1996). IL-3 receptor expression, regulation and function in cells of the vasculature. Immunology and Cell Biology, 74(1), 1-7. Scopus57 WoS56 Europe PMC47 |
| 1996 | Till, K. J., Burthem, J., Lopez, A., & Cawley, J. C. (1996). Granulocyte-macrophage colony-stimulating factor receptor: Stage- specific expression and function on late B cells. Blood, 88(2), 479-486. Scopus30 WoS31 Europe PMC18 |
| 1996 | Woodcock, J. M., Baglev, C. J., Zacharakis, B., & Lopez, A. F. (1996). Tyrosine421 in the GM-CSF, il-3 and IL-5 receptor common β chain is necessary and sufficient for binding and signalling by all three ligands. FASEB Journal, 10(6), A1311. |
| 1996 | Barbara, I. A. J., Smith, W. B., VanOstade, X., Fiers, W., Vadas, M. A., & Lopez, A. F. (1996). The proinflammatory and cytotoxic activities of TNF-alpha.. KIDNEY INTERNATIONAL, 50(4), 1394. |
| 1996 | Barbara, J. A. J., Van Ostade, X., & Lopez, A. F. (1996). Tumour necrosis factor-alpha (TNF-α): The good, the bad and potentially very effective. Immunology and Cell Biology, 74(5), 434-443. Scopus107 WoS102 Europe PMC81 |
| 1996 | Sun, Q., Woodcock, J. M., Bagley, C. J., Jones, K., DAndrea, R., & Lopez, A. F. (1996). A monoclonal antibody (MoAb) to the human IL-3, GM-CSF and IL-5 receptor common beta-chain (beta(c)) neutralises the binding and function of all three ligands.. BLOOD, 88(10), 2170. WoS1 |
| 1995 | Till, K. J., Burthem, J., Lopez, A. F., & Cawley, J. C. (1995). Late B cells express receptors for GM-CSF, and the cytokine inhibits B-cell movement.. BLOOD, 86(10), 90. |
| 1995 | Korpelainen, E. I., Gamble, J. R., Smith, W. B., Dottore, M., Vadas, M. A., & Lopez, A. F. (1995). Interferon-γ upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production. Blood, 86(1), 176-182. Scopus42 WoS42 Europe PMC24 |
| 1995 | Korpelainen, E., Gamble, J., Smith, W., Dottore, M., Vadas, M., & Lopez, A. (1995). Interferon gamma upregulates IL-3 receptor expression in human endothelial cells and synergises with IL-3 in stimulating MHC class II expression and cytokine production. Blood, 86, 176-182. |
| 1995 | Bagley, C., Woodcock, J., Hercus, T., Shannon, M., & Lopez, A. (1995). The interaction of GM-CSF and IL-3 with the common beta chain of their receptors. Journal of Leukocyte Biology, 57(5), 739-746. Scopus27 WoS24 Europe PMC19 |
| 1995 | Smith, W., Guida, L., Qiuy, S., Korpelainen, E., van den Hueven, C., Gillis, D., . . . Lopez, A. (1995). Neutrophils activated by granulocyte-macrophage colony-stimulating factor express receptors for interleukin-3 which mediate class II expression. Blood, 86(10), 3938-3944. Scopus71 WoS67 Europe PMC46 |
| 1994 | Woodcock, J. M., Zacharakis, B., Plaetinck, G., Bagley, C. J., Qiyu, S., Hercus, T. R., . . . Lopez, A. F. (1994). Three residues in the common β chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO Journal, 13(21), 5175-5185. Scopus105 Europe PMC76 |
| 1994 | Hercus, T. R., Bagley, C. J., Cambareri, B., Dottore, M., Woodcock, J. M., Vadas, M. A., . . . Lopez, A. F. (1994). Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5838-5842. Scopus107 WoS104 Europe PMC69 |
| 1994 | Hercus, T. R., Cambareri, B., Dottore, M., Woodcock, J., Bagley, C. J., Vadas, M. A., . . . Lopez, A. F. (1994). Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the α- and β-chains of its receptor. Blood, 83(12), 3500-3508. Scopus69 WoS67 Europe PMC37 |
| 1994 | Barbara, J. A. J., Smith, W. B., Gamble, J. R., Van Ostade, X., Vandenabeele, P., Tavernier, J., . . . Lopez, A. F. (1994). Dissociation of TNF-α cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-α mutants. EMBO Journal, 13(4), 843-850. Scopus145 WoS145 Europe PMC93 |
| 1994 | BAGLEY, C. J., WOODCOCK, J. M., BARRY, S. C., PHILLIPS, J. A., DOTTORE, M., CAMBARERI, B., . . . LOPEZ, A. F. (1994). INTERACTION OF THE FIRST AND 4TH HELICES OF INTERLEUKIN-3 WITH THE ALPHA-CHAINS AND BETA-CHAINS OF ITS RECEPTOR. JOURNAL OF CELLULAR BIOCHEMISTRY, 17. WoS1 |
| 1994 | WOODCOCK, J. M., ZACHARAKIS, B., PLAETINCK, G., BAGLEY, C. J., QIYU, S., HERCUS, T. R., & LOPEZ, A. F. (1994). 3 RESIDUES IN THE COMMON BETA-CHAIN OF THE HUMAN GM-CSF, IL-3 AND IL-5 RECEPTORS ARE ESSENTIAL FOR GM-CSF AND IL-5 BUT NOT IL-3 HIGH-AFFINITY BINDING AND INTERACT WITH GLU21 OF GM-CSF. EMBO JOURNAL, 13(21), 5176-5185. WoS105 |
| 1994 | Barry, S. C., Bagley, C. J., Phillips, J., Dottore, M., Cambareri, B., Moretti, P., . . . Lopez, A. F. (1994). Two contiguous residues in human interleukin-3, Asp 21 and Glu 22, selectively interact with the α- and β-chains of its receptor and participate in function. Journal of Biological Chemistry, 269(11), 8488-8492. Scopus76 WoS76 Europe PMC48 |
| 1994 | Vadas, M., Lopez, A., Gamble, J., Khew-Goodall, Y., Smith, W., Bernard, C., . . . Hercus, T. (1994). Cytokines and allergy. Journal of Allergy and Clinical Immunology, 94(6 PART 2), 1289-1293. Scopus13 WoS12 Europe PMC11 |
| 1994 | Kazazi, F., Chang, J., Lopez, A., Vadas, M., & Cunningham, A. L. (1994). Interleukin 4 and human immunodeficiency virus stimulate LFA-1-ICAM-1-mediated aggregation of monocytes and subsequent giant cell formation. Journal of General Virology, 75(10), 2795-2802. Scopus36 WoS32 Europe PMC24 |
| 1994 | D'Andrea, R., Rayner, J., Moretti, P., Lopez, A., Goodall, G. J., Gonda, T. J., & Vadas, M. (1994). A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity. Blood, 83(10), 2802-2808. Scopus54 WoS57 Europe PMC32 |
| 1993 | Till, K. J., Lopez, A., Slupsky, J., & Cawley, J. C. (1993). C‐fms protein expression by B‐cells, with particular reference to the hairy cells of hairy‐cell leukaemia. British Journal of Haematology, 83(2), 223-231. Scopus29 WoS32 Europe PMC14 |
| 1993 | BAGLEY, C. J., PHILLIPS, J. A., DOTTORE, M., CAMBARERI, B., & LOPEZ, A. F. (1993). INTERACTION OF THE 1ST AND 4TH HELICES OF INTERLEUKIN-3 WITH THE ALPHA-CHAIN AND BETA-CHAIN OF ITS RECEPTOR. JOURNAL OF LEUKOCYTE BIOLOGY, 69. |
| 1993 | LOPEZ, A. F., BAGLEY, C., DANDREA, R., GOODALL, G., HERCUS, T., SHANNON, M. F., . . . WOODCOCK, J. (1993). THE STRUCTURAL BASIS FOR THE INTERACTION OF HEMATOPOIETIC GROWTH-FACTORS WITH THEIR RECEPTORS. JOURNAL OF LEUKOCYTE BIOLOGY, 108. |
| 1993 | Weich, N. S., Tullai, J., Guido, E., McMahon, M., Jolliffe, L. K., Lopez, A. F., . . . Rosen, J. (1993). Interleukin-3/erythropoietin fusion proteins: In vitro effects on hematopoietic cells. Experimental Hematology, 21(5), 647-655. Scopus13 WoS13 Europe PMC7 |
| 1993 | LOPEZ, A. F., SHANNON, M. F., GOODALL, G., BARRY, S., HERCUS, T., PHILLIPS, J., . . . VADAS, M. A. (1993). IDENTIFICATION OF RESIDUES IN IL-3 AND GM-CSF INTERACTING WITH THE ALPHA-CHAIN AND BETA-CHAIN OF THEIR RECEPTORS. JOURNAL OF CELLULAR BIOCHEMISTRY, 79. |
| 1993 | GOODALL, G. J., BAGLEY, C. J., DANDREA, R. J., VADAS, M. A., & LOPEZ, A. F. (1993). INTERACTIONS BETWEEN HUMAN IL-3 AND ITS RECEPTOR. JOURNAL OF CELLULAR BIOCHEMISTRY, 75. |
| 1993 | Korpelainen, E. I., Gamble, J. R., Smith, W. B., Goodall, G. J., Qiyu, S., Woodcock, J. M., . . . Lopez, A. F. (1993). The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor α and potentiates interleukin 8 secretion and neutrophil transmigration. Proceedings of the National Academy of Sciences of the United States of America, 90(23), 11137-11141. Scopus75 WoS74 Europe PMC49 |
| 1993 | Kremer, E., Baker, E., D'Andrea, R. J., Slim, R., Phillips, H., Moretti, P. A. B., . . . Goodall, G. J. (1993). A cytokine receptor gene cluster in the X-Y pseudoautosomal region?. Blood, 82(1), 22-28. Scopus44 WoS40 Europe PMC25 |
| 1993 | Goodall, G. J., Bagley, C. J., Vadas, M. A., & Lopez, A. F. (1993). A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands. Growth Factors, 8(2), 87-97. Scopus77 WoS79 Europe PMC62 |
| 1992 | Lopez, A. F., Shannon, M. F., Barry, S., Phillips, J. A., Cambareri, B., Dottore, M., . . . Vadas, M. A. (1992). A human interleukin 3 analog with increased biological and binding activities. Proceedings of the National Academy of Sciences of the United States of America, 89(24), 11842-11846. Scopus46 WoS43 Europe PMC27 |
| 1992 | Lopez, A. F., Elliott, M. J., Woodcock, J., & Vadas, M. A. (1992). GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells. Immunology Today, 13(12), 495-500. Scopus139 WoS143 Europe PMC97 |
| 1992 | Bardy, P. G., Lopez, A. F., Moore, S., Park, L. S., Vadas, M. A., & Shannon, M. F. (1992). Human GM-CSF receptor α-chain gene is highly polymorphic but not rearranged in AML. Leukemia, 6(9), 893-897. Scopus5 WoS4 Europe PMC3 |
| 1992 | Hardy, S. J., Haylock, D. N., Lopez, A. F., & Murray, A. W. (1992). Examination of the role of the proteolytically-activated form of protein kinase C in the differentiation of human haemopoietic cells. Differentiation, 50(3), 189-202. Scopus4 WoS5 Europe PMC1 |
| 1992 | Lopez, A. F., Frances Shannon, M., Hercus, T., Nicola, N. A., Cambareri, B., Dottore, M., . . . Vadas, M. A. (1992). Residue 21 of human granulocyte-macrophage colonystimulating factor is critical for biological activity and for high but not low affinity binding. EMBO Journal, 11(3), 909-916. Scopus109 WoS107 Europe PMC75 |
| 1992 | Lopez, A. F., Shannon, M. F., Chia, M. M., Park, L., & Vadas, M. A. (1992). Regulation of human eosinophil production and function by interleukin-5.. Immunology Series, 57, 549-571. Scopus17 Europe PMC11 |
| 1992 | Elliott, M. J., Moss, J., Dottore, M., Park, L. S., Vadas, M. A., & Lopez, A. F. (1992). Differential binding of IL-3 and GM-CSF to human monocytes. Growth Factors, 6(1), 15-29. Scopus14 WoS15 Europe PMC8 |
| 1992 | Kazazi, F., Mathijs, J. M., Chang, J., Malafiej, P., Lopez, A., Dowton, D., . . . Cunningham, A. L. (1992). Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages. Journal of General Virology, 73(4), 941-949. Scopus46 WoS51 Europe PMC37 |
| 1991 | PARK, L. S., WILLIAMS, D. E., LOPEZ, A. F., & LARSEN, A. (1991). HUMAN INTERLEUKIN-3 RECEPTOR - STRUCTURE AND FUNCTION. EXPERIMENTAL HEMATOLOGY, 19(6), 458. |
| 1991 | Stewart, A. G., Harris, T., De Nichilo, M., & Lopez, A. F. (1991). Involvement of leukotriene B4 and platelet-activating factor in cytokine priming of human polymorphonuclear leucocytes. Immunology, 72(2), 206-212. Scopus22 WoS30 Europe PMC16 |
| 1991 | Lopez, A. F., Vadas, M. A., Woodcock, J. M., Milton, S. E., Lewis, A., Elliott, M. J., . . . Park, L. S. (1991). Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. Journal of Biological Chemistry, 266(36), 24741-24747. Scopus122 WoS129 Europe PMC91 |
| 1991 | Elliott, M. J., Gamble, J. R., Park, L. S., Vadas, M. A., & Lopez, A. F. (1991). Inhibition of human monocyte adhesion by interleukin-4. Blood, 77(12), 2739-2745. Scopus46 WoS50 Europe PMC23 |
| 1991 | Ryan, G. R., Milton, S. E., Lopez, A. F., Bardy, P. G., Vadas, M. A., & Shannon, M. F. (1991). Human interleukin-3 mRNA accumulation is controlled at both the transcriptional and posttranscriptional level. Blood, 77(6), 1195-1202. Scopus29 WoS33 Europe PMC15 |
| 1991 | DeNichilo, M. O., Stewart, A. G., Vadas, M. A., & Lopez, A. F. (1991). Granulocyte-macrophage colony-stimulating factor is a stimulant of platelet-activating factor and superoxide anion generation by human neutrophils. Journal of Biological Chemistry, 266(8), 4896-4902. Scopus32 WoS40 Europe PMC26 |
| 1991 | Vadas, M. A., Lopez, A. F., Gamble, J. R., & Elliot, M. J. (1991). Role of colony-stimulating factors in leucocyte responses to inflammation and infection. Current Opinion in Immunology, 3(1), 97-104. Scopus11 WoS12 Europe PMC9 |
| 1990 | Lopez, A. F., Eglinton, J. M., Lyons, A. B., Tapley, P. M., To, L. B., Park, L. S., . . . Vadas, M. A. (1990). Human Interleukin‐3 inhibits the binding of granulocyte‐macrophage colony‐stimulating factor and interleukin‐5 to basophils and strongly enhances their functional activity. Journal of Cellular Physiology, 145(1), 69-77. Scopus115 WoS125 Europe PMC78 |
| 1990 | Gamble, J. R., Rand, T. H., Lopez, A. F., Clark-Lewis, I., & Vadas, M. A. (1990). Heterogeneity of recombinant granulocyte-macrophage colony-stimulating factor-mediated enhancement of neutrophil adherence to endothelium. Experimental Hematology, 18(8), 897-902. Scopus11 WoS13 Europe PMC7 |
| 1990 | Elliott, M. J., Vadas, M. A., Cleland, L. G., Gamble, J. R., & Lopez, A. F. (1990). IL-3 and granulocyte-macrophage colony-stimulating factor stimulate two distinct phases of adhesion in human monocytes. Journal of Immunology, 145(1), 167-176. Scopus81 WoS86 Europe PMC47 |
| 1990 | Atkinson, Y. H., Murray, A. W., Krilis, S., Vadas, M. A., & Lopez, A. F. (1990). Human tumour necrosis factor-alpha (TNF-α) directly stimulates arachidonic acid release in human neutrophils. Immunology, 70(1), 82-87. Scopus49 WoS54 Europe PMC38 |
| 1990 | Krissansen, G. W., Elliott, M. J., Lucas, C. M., Stomski, F. C., Berndt, M. C., Cheresh, D. A., . . . Burns, G. F. (1990). Identification of a novel integrin β subunit expressed on cultured monocytes (macrophages): Evidence that one α subunit can associate with multiple β subunits. Journal of Biological Chemistry, 265(2), 823-830. Scopus88 WoS95 Europe PMC61 |
| 1990 | Lopez, A. F., Lyons, A. B., Eglinton, J. M., Park, L. S., To, L. B., Clark, S. C., & Vadas, M. A. (1990). Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils. Journal of Allergy and Clinical Immunology, 85(1 PART 1), 99-102. Scopus30 WoS34 Europe PMC23 |
| 1990 | Stewart, A. G., Harris, T., de Nicholo, M., & Lopez, A. F. (1990). Intracellular platelet-activating factor in endotoxin and cytokine-primed polymorphonuclear leukocytes. European Journal of Pharmacology, 183(4), 1130. |
| 1989 | Spitalnik, P. F., Spitalnik, S. L., Danley, J. M., Lopez, A. F., Vadas, M. A., Civin, C. I., & Ginsburg, V. (1989). Carbohydrate-specific monoclonal antibodies bind to human granulocytes and stimulate antibody-dependent cellular cytotoxicity. Archives of Biochemistry and Biophysics, 271(1), 168-176. Scopus7 WoS7 Europe PMC6 |
| 1989 | Phillips, J. A., Lopez, A. F., Milton, S. E., Vadas, M. A., & Shannon, M. F. (1989). Synthesis and expression of the gene encoding human interleukin-3. Gene, 84(2), 501-507. Scopus6 WoS6 Europe PMC4 |
| 1989 | Elliott, M. J., Vadas, M. A., Eglinton, J. M., Park, L. S., To, L. B., Cleland, L. G., . . . Lopez, A. F. (1989). Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes. Blood, 74(7), 2349-2359. Scopus135 WoS151 Europe PMC72 |
| 1989 | Gamble, J. R., Elliott, M. J., Jaipargas, E., Lopez, A. F., & Vadas, M. A. (1989). Regulation of human monocyte adherence by granulocyte-macrophage colony-stimulating factor. Proceedings of the National Academy of Sciences of the United States of America, 86(18), 7169-7173. Scopus69 WoS75 Europe PMC42 |
| 1989 | Lopez, A. F., Eglinton, J. M., Gillis, D., Park, L. S., Clark, S., & Vadas, M. A. (1989). Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils. Proceedings of the National Academy of Sciences of the United States of America, 86(18), 7022-7026. Scopus114 WoS126 Europe PMC75 |
| 1989 | Jin, B., Lopez, A. F., Gillis, S., Juttner, C. A., Vadas, M. A., & Burns, G. F. (1989). Human interleukin 4 regulates the phenotype of lymphocytes generated during mixed lymphocyte culture and inhibits the IL-2-induced development of LAK function in normal and leukaemic cells. Leukemia Research, 13(4), 297-305. Scopus5 WoS3 Europe PMC2 |
| 1988 | Lopez, A. F., Dyson, P. G., To, L. B., Elliott, M. J., Milton, S. E., Russell, J. A., . . . Vadas, M. A. (1988). Recombinant human interleukin-3 stimulation of hematopoiesis in humans: Loss of responsiveness with differentiation in the neutrophilic myeloid series. Blood, 72(5), 1797-1804. Scopus82 WoS99 Europe PMC42 |
| 1988 | Ferrante, A., Carter, R. F., Lopez, A. F., Rowen-Kelly, B., Hill, N. L., & Vadas, M. A. (1988). Depression of immunity to Naegleria fowleri in mice by selective depletion of neutrophils with a monoclonal antibody. Infection and Immunity, 56(9), 2286-2291. Scopus24 WoS29 Europe PMC23 |
| 1988 | Atkinson, Y. H., Lopez, A. F., Marasco, W. A., Lucas, C. M., Wong, G. G., Burns, G. F., & Vadas, M. A. (1988). Recombinant human ganulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils. Immunology, 64(3), 519-525. Scopus59 WoS72 Europe PMC47 |
| 1988 | Atkinson, Y. H., Marasco, W. A., Lopez, A. F., & Vadas, M. A. (1988). Recombinant human tumor necrosis factor-α. Regulation of N-formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils. Journal of Clinical Investigation, 81(3), 759-765. Scopus147 WoS196 Europe PMC118 |
| 1988 | Simmers, R. N., Smith, J., Shannon, M. F., Wong, G., Lopez, A. F., Baker, E., . . . Vadas, M. A. (1988). Localization of the human G-CSF gene to the region of a breakpoint in the translocation typical of acute promyelocytic leukemia. Human Genetics, 78(2), 134-136. Scopus7 WoS8 Europe PMC7 |
| 1988 | Rand, T. H., Lopez, A. F., Gamble, J. R., & Vadas, M. A. (1988). Nedocromil sodium and cromolyn (Sodium cromoglycate) selectively inhibit antibody-dependent granulocyte-media ted cytotoxicity. International Archives of Allergy and Immunology, 87(2), 151-158. Scopus21 WoS30 Europe PMC24 |
| 1988 | Lopez, A. F., Sanderson, C. J., Gamble, J. R., Campbell, H. D., Young, I. G., & Vadas, M. A. (1988). Recombinant human interleukin 5 is a selective activator of human eosinophil function. Journal of Experimental Medicine, 167(1), 219-224. Scopus856 WoS899 Europe PMC634 |
| 1988 | SIMMERS, R. N., WEBBER, L. M., BAKER, E. G., SMITH, J., SHANNON, M. F., LOPEZ, A. F., . . . SUTHERLAND, G. R. (1988). LOCALIZATION OF THE G-CSF GENE TO 17Q11.2-]Q21, PROXIMAL TO THE BREAKPOINT IN THE T(15-17) OF ACUTE PROMYELOCYTIC LEUKEMIA. AUSTRALIAN PAEDIATRIC JOURNAL, 24(1), 96. |
| 1988 | Emery, P., Lopez, A. F., Burns, G. F., & Vadas, M. A. (1988). Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes that reflect activation. Annals of the Rheumatic Diseases, 47(1), 34-39. Scopus33 WoS46 Europe PMC35 |
| 1988 | Clark-Lewis, I., Lopez, A. F., To, L. B., Vadas, M. A., Schrader, J. W., Hood, L. E., & Kent, S. B. H. (1988). Structure-function studies of human granulocyte-macrophage colony-stimulating factor: Identification of residues required for activity. Journal of Immunology, 141(3), 881-889. Scopus64 WoS72 Europe PMC33 |
| 1988 | VADAS, M. A., LOPEZ, A. F., SHANNON, M. F., EGLINTON, L., TO, L. B., EGLINTON, J., & RAND, T. H. (1988). HUMAN GM-CSF MUTANTS REVEAL DISSOCIATION BETWEEN ACTIVATION OF MATURE CELLS AND STIMULATION OF PROGENITORS MYELOID CELLS. LYMPHOKINE RESEARCH, 7(3), 291. WoS2 |
| 1988 | LOPEZ, A. F., TO, L. B., DYSON, P. G., RUSSELL, J. A., MILTON, S. A., YANG, Y. C., . . . VADAS, M. A. (1988). RECOMBINANT HUMAN INTERLEUKIN-3 STIMULATION OF HEMATOPOIESIS IN MAN - SELECTIVE LOSS OF RESPONSIVENESS OF NEUTROPHILIC GRANULOCYTES WITH DIFFERENTIATION. EXPERIMENTAL HEMATOLOGY, 16(6), 536. WoS1 |
| 1988 | Sutherland, G. R., Baker, E., Callen, D. F., Hyland, V. J., Wong, G., Clark, S., . . . Vadas, M. A. (1988). Interleukin 4 is at 5q31 and interleukin 6 is at 7p15. Human Genetics, 79(4), 335-337. Scopus94 WoS99 Europe PMC63 |
| 1988 | Sutherland, G. R., Baker, E., Callen, D. F., Campbell, H. D., Young, I. G., Sanderson, C. J., . . . Vadas, M. A. (1988). Interleukin-5 is at 5q31 and is deleted in the 5q-syndrome. Blood, 71(4), 1150-1152. Scopus89 WoS94 Europe PMC42 |
| 1987 | LOPEZ, A. F., CLARKLEWIS, I., KENT, S. B. H., TO, L. B., WONG, G., HOOD, L. E., . . . VADAS, M. A. (1987). BIOLOGICAL PROPERTIES OF RECOMBINANT AND CHEMICALLY-SYNTHESIZED HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (CM-CSF). LYMPHOKINE RESEARCH, 6(1), U90. |
| 1987 | SHANNON, M. F., SIMMERS, R. N., SMITH, J., WONG, G., LOPEZ, A. F., BAKER, E., . . . VADAS, M. A. (1987). LOCALIZATION OF THE HUMAN G-CSF GENE TO THE REGION OF A BREAKPOINT IN THE TRANSLOCATION TYPICAL OF ACUTE PROMYELOCYTIC LEUKEMIA. LYMPHOKINE RESEARCH, 6(1), U91. WoS1 |
| 1987 | Vadas, M. A., Lopez, A. F., Shannon, M. F., & Atkinson, Y. (1987). Human myeloid growth factors. Immunology and Cell Biology, 65(2), 141-145. Scopus5 WoS4 Europe PMC3 |
| 1987 | Hart, P. H., Spencer, L. K., Kenny, P. A., Lopez, A. F., McDonald, P. J., & Finlay-Jones, J. J. (1987). Functional neutrophils from long-term murine bone marrow cell cultures. Journal of Immunological Methods, 100(1-2), 223-233. Scopus6 WoS9 Europe PMC6 |
| 1987 | Lopez, A. F., To, L. B., Yang, Y. C., Gamble, J. R., Shannon, M. F., Burns, G. F., . . . Vadas, M. A. (1987). Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2761-2765. Scopus177 WoS224 Europe PMC45 |
| 1987 | VADAS, M. A., ATKINSON, V. H., & LOPEZ, A. F. (1987). RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA(RHTNF-ALPHA) - REGULATION OF FMET-LEU-PHE RECEPTOR EXPRESSION AND FUNCTION ON HUMAN-NEUTROPHILS. IMMUNOBIOLOGY, 175(1-2), 122. WoS1 |
| 1987 | Puddington, L., Woodgett, C., & Rose, J. K. (1987). Replacement of the cytoplasmic domain alters sorting of a viral glycoprotein in polarized cells.. Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2756-2760. Europe PMC94 |
| 1987 | Burgess, A. W., Begley, C. G., Johnson, G. R., Lopez, A. F., Williamson, D. J., Mermod, J. J., . . . DeLamarter, J. F. (1987). Purification and properties of bacterially synthesized human granulocyte-macrophage colony stimulating factor. Blood, 69(1), 43-51. Scopus222 WoS249 Europe PMC97 |
| 1987 | TO, L. B., LOPEZ, A. F., YANG, Y. C., GAMBLE, J. R., DYSON, P. G., SHANNON, M. F., . . . VADAS, M. A. (1987). STIMULATION OF PROLIFERATION, DIFFERENTIATION AND FUNCTION OF HUMAN-CELLS BY PRIMATE INTERLEUKIN-3. EXPERIMENTAL HEMATOLOGY, 15(5), 563. |
| 1986 | Metcalf, D., Begley, C. G., Johnson, G. R., Nicola, N. A., Vadas, M. A., Lopez, A. F., . . . Wang, E. A. (1986). Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor. Blood, 67(1), 37-45. Scopus396 WoS518 Europe PMC208 |
| 1986 | Metcalf, D., Begley, C. G., Johnson, G. R., Nicola, N. A., Lopez, A. F., & Williamson, D. J. (1986). Effects of purified bacterially synthesized murine Multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood, 68(1), 46-57. Scopus250 WoS328 Europe PMC144 |
| 1986 | Nicola, N. A., Vadas, M. A., & Lopez, A. F. (1986). Down‐modulation of receptors for granulocyte colony‐stimulating factor on human neutrophils by granulocyte‐activating agents. Journal of Cellular Physiology, 128(3), 501-509. Scopus69 WoS80 Europe PMC37 |
| 1986 | Burns, G. F., Cosgrove, L., Triglia, T., Beall, J. A., López, A. F., Werkmeister, J. A., . . . Cawley, J. C. (1986). The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Cell, 45(2), 269-280. Scopus56 WoS92 Europe PMC53 |
| 1986 | Hart, P. H., Spencer, L. K., Nikoloutsopoulos, A., Lopez, A. F., Vadas, M. A., Mcdonald, P. J., & Finlay-Jones, J. J. (1986). Role of cell surface receptors in the regulation of intracellular killing of bacteria by murine peritoneal exudate neutrophils. Infection and Immunity, 52(1), 245-251. Scopus18 WoS24 Europe PMC17 |
| 1986 | Lopez, A. F., Begley, C. G., Williamson, D. J., Warren, D. J., Vadas, M. A., & Sanderson, C. J. (1986). Murine eosinophil differentiation factor: An eosinophil-specific colony-stimulating factor with activity for human cells. Journal of Experimental Medicine, 163(5), 1085-1099. Scopus156 WoS164 Europe PMC113 |
| 1986 | LOPEZ, A. F., WILLIAMSON, D. J., BEGLEY, C. G., NICOLA, N. A., WONG, G., CLARK, S. C., & VADAS, M. A. (1986). A RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (RH GM-CSF) STIMULATES INVITRO MATURE HUMAN NEUTROPHIL AND EOSINOPHIL FUNCTION, SURFACE-RECEPTOR EXPRESSION AND SURVIVAL. JOURNAL OF CELLULAR BIOCHEMISTRY, 93. |
| 1986 | Begley, C. G., Lopez, A. F., Nicola, N. A., Warren, D. J., Vadas, M. A., Sanderson, C. J., & Metcalf, D. (1986). Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: A rapid and sensitive microassay for colony-stimulating factors. Blood, 68(1), 162-166. Scopus240 WoS276 Europe PMC153 |
| 1986 | LOPEZ, A. F., BEGLEY, C. G., WILLIAMSON, D. J., NICOLA, N. A., WARREN, D. J., SANDERSON, C. J., . . . VADAS, M. A. (1986). LINEAGE-SPECIFIC STIMULATION OF MATURE CELLS BY CSF. FEDERATION PROCEEDINGS, 45(3), 264. |
| 1986 | Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlan, J. M., Klebanoff, S. J., . . . Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. Journal of Clinical Investigation, 78(5), 1220-1228. Scopus635 WoS785 Europe PMC461 |
| 1986 | BURNS, G. F., LOPEZ, A. F., BEALL, J. A., VADAS, M. A., & BEGLEY, C. G. (1986). A FUNCTIONAL-ROLE FOR THE IIB-IIIA GLYCOPROTEIN COMPLEX PRESENT ON LEUKOCYTES. FEDERATION PROCEEDINGS, 45(3), 635. |
| 1985 | Pentilla, I. A., Ey, P. L., Lopez, A. F., & Jenkin, C. R. (1985). Suppression of early immunity to Nematospiroides dubius in mice by selective depletion of neutrophils with monoclonal antibody. Australian Journal of Experimental Biology and Medical Science, 63(5), 531-543. Scopus8 Europe PMC7 |
| 1985 | PENTILLA, I. A., EY, P. L., LOPEZ, A. F., & JENKIN, C. R. (1985). SUPPRESSION OF EARLY IMMUNITY TO NEMATOSPIROIDES-DUBIUS IN MICE BY SELECTIVE DEPLETION OF NEUTROPHILS WITH MONOCLONAL-ANTIBODY. AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 63(OCT), 531-543. WoS11 |
| 1985 | Vadas, M. A., Lopez, A. F., & Williamson, D. J. (1985). Selective enhancement of the expression of granulocyte functional antigens 1 and 2 on human neutrophils. Proceedings of the National Academy of Sciences of the United States of America, 82(8), 2503-2507. Scopus10 WoS20 Europe PMC7 |
| 1985 | Begley, C. G., Metcalf, D., Lopez, A. F., & Nicola, N. A. (1985). Fractioned populations of normal human marrow cells respond to both human colony-stimulating factors with granulocyte-macrophage activity. Experimental Hematology, 13(9), 956-962. Scopus24 WoS28 Europe PMC6 |
| 1985 | Vadas, M. A., Clarke, C., Nicola, N. A., & Lopez, A. F. (1985). Correlation between the stimulation of human neutrophil function by monoclonal antibody and by colony-stimulating factor. Blood, 66(3), 738-741. Scopus7 WoS13 Europe PMC3 |
| 1985 | Lopez, A. F., Begley, G., Andrews, P., Butterworth, A. E., & Vadas, M. A. (1985). Identification of a human granulocyte functional antigen (GFA-2) involved in antibody-dependent cell-mediated cytotoxicity and phagocytosis. Journal of Immunology, 134(6), 3969-3977. Scopus17 WoS26 Europe PMC10 |
| 1985 | Begley, C. G., Lopez, A. F., Vadas, M. A., & Metcalf, D. (1985). The clonal proliferation in vitro of enriched populations of human promyelocytes and myelocytes. Blood, 65(4), 951-958. Scopus17 WoS25 Europe PMC10 |
| 1985 | Lopez, A. F., Battye, F. L., & Vadas, M. A. (1985). Fc receptors on mouse neutrophils and eosinophils: Antigenic characteristics, isotype specificity and relative cell membrane density measured by flow cytometry. Immunology, 55(1), 125-133. Scopus14 WoS18 Europe PMC13 |
| 1984 | Vadas, M. A., Nicola, N., Lopez, A. F., Metcalf, D., Johnson, G., & Pereira, A. (1984). Mononuclear cell-mediated enhancement of granulocyte function in man. Journal of Immunology, 133(1), 202-207. Scopus40 WoS67 Europe PMC32 |
| 1984 | Lopez, A. F., Triglia, T., Werkmeister, J. A., & Burns, G. F. (1984). A mature myeloid antigen identified on human natural killer cells. Australian Journal of Experimental Biology and Medical Science, 62(4), 445-451. |
| 1984 | Vadas, M. A., Lopez, A. F., & Begley, C. G. (1984). Stimulation of human granulocyte function by monoclonal antibody. Federation Proceedings, 43(6). |
| 1984 | Lopez, A. F., & Vadas, M. A. (1984). Stimulation of human granulocyte function by monoclonal antibody WEM-G1. Proceedings of the National Academy of Sciences of the United States of America, 81(6 I), 1818-1821. Scopus17 WoS31 Europe PMC11 |
| 1984 | López, A. F., Burns, G. F., & Stanley, I. J. (1984). Epitope diversity of monoclonal antibodies revealed by cross-species reactivity. Molecular Immunology, 21(5), 371-374. Scopus6 WoS16 Europe PMC11 |
| 1984 | Lopez, A. F., Strath, M., & Sanderson, C. J. (1984). Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies. British Journal of Haematology, 57(3), 489-494. Scopus80 WoS93 Europe PMC74 |
| 1984 | Vadas, M. A., & Lopez, A. F. (1984). Regulation of granulocyte function by colony stimulating factors. Lymphokine Research, 3(2), 45-50. Scopus7 WoS10 Europe PMC6 |
| 1983 | LÓPEZ, A. F., SANTOS, R. R. D., & SANDERSON, C. J. (1983). Antibody‐dependent cytotoxicity of Trypanosoma cruzi antigen‐coated mouse cell lines by eosinophils and neutrophils. Parasite Immunology, 5(1), 77-84. Scopus1 WoS6 Europe PMC1 |
| 1983 | Lopez, A. F., Strath, M., & Sanderson, C. J. (1983). Mouse immunoglobulin isotypes mediating cytotoxicity of target cells by eosinophils and neutrophils. Immunology, 48(3), 503-509. Scopus22 WoS36 Europe PMC21 |
| 1983 | Lopez, A. F., Nicola, N. A., Burgess, A. W., Metcalf, D., Battye, F. L., Sewell, W. A., & Vadas, M. (1983). Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors. Journal of Immunology, 131(6), 2983-2988. Scopus166 WoS232 Europe PMC82 |
| 1982 | Lopez, A. F., & Sanderson, C. J. (1982). Antibody-dependent, cell-mediated cytotoxicity of nucleated mammalian cells by rat eosinophils and neutrophils. International Archives of Allergy and Applied Immunology, 67(3), 200-205. Scopus7 WoS9 Europe PMC6 |
| 1981 | Lopez, A. F., Strath, M., & Sanderson, C. J. (1981). IgG and complement receptors on purified mouse eosinophils and neutrophils. Immunology, 43(4), 779-786. Scopus20 WoS33 Europe PMC25 |
| 1978 | Sanderson, C. J., Moreno, M. M. B., & Lopez, A. F. (1978). Antibody dependent cell-mediated cytotoxicity of Trypanosoma cruzi: The release of tritium-labelled RNA, DNA and protein. Parasitology, 76(3), 299-307. Scopus18 WoS31 Europe PMC17 |
| 1978 | López, A. F., Moreno, M. M. B., & Sanderson, C. J. (1978). The lysis of Trypanosoma cruzi epimastigotes by eosinophils and neutrophils. International Journal for Parasitology, 8(6), 485-489. Scopus9 WoS19 Europe PMC11 |
| 1977 | Sanderson, C. J., Lopez, A. F., & Moreno, M. M. B. (1977). Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes. Nature, 268(5618), 340-341. Scopus30 WoS64 Europe PMC37 |
| Year | Citation |
|---|---|
| 2005 | Thomas, D., Guthridge, M., Woodcock, J., & Lopez, A. (2005). Protein Signaling in Development and Growth Factor Responses (Vol. 67). G. P. Schatten (Ed.), ELSEVIER ACADEMIC PRESS INC. DOI Scopus38 WoS36 Europe PMC31 |
| Year | Citation |
|---|---|
| 2016 | Yip, K. H., Kolesnikoff, N., Hauschild, N., Lopez, A. F., Galli, S. J., Kumar, S., & Grimbaldeston, M. A. (2016). The Nedd4-2-Ndfip1 axis is essential to curtail mast cell-dependent IgE-mediated anaphylaxis <i>in vivo</i>. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 16-17). Melbourne, AUSTRALIA: WILEY-BLACKWELL. |
| 2014 | Broughton, S. E., Hercus, T. R., Nero, T. L., Dhagat, U., Dottore, M., McClure, B. J., . . . Parker, M. W. (2014). Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex. In CYTOKINE Vol. 70 (pp. 32). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. DOI |
| 2014 | Hercus, T. R., Broughton, S. E., Hardy, M. P., Nero, T. L., McClure, B. J., Dottore, M., . . . Lopez, A. F. (2014). Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123. In CYTOKINE Vol. 70 (pp. 46). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. DOI WoS1 |
| 2011 | Nievergall, E., White, D. L., Ramshaw, H., Lopez, A. F., Hughes, T. P., & Hiwase, D. K. (2011). Antibody-Targeting of IL-3 Receptor-α Increases the Susceptibility of CD34<SUP>+</SUP> CML Progenitors to Dasatinib-Induced Cell Death. In BLOOD Vol. 118 (pp. 1599). San Diego, CA: AMER SOC HEMATOLOGY. DOI WoS1 |
| 2010 | Sadras, T., Perugini, M., Ramshaw, H. S., Salerno, D. G., Lewis, I. D., Lopez, A. F., . . . D'Andrea, R. J. (2010). IL-3 MEDIATED ACTIVATION OF β-CATENIN IN ACUTE MYELOID LEUKEMIA. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S59). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. |
| 2010 | Thomas, D., Powell, J. A., Barry, E. F., Woodcock, J., Ekert, P. G., Green, B. D., . . . Guthridge, M. A. (2010). THE PROTEIN KINASE ACTIVITY OF PHOSPHOINOSITIDE 3-KINASE ALPHA PROMOTES AUTONOMOUS CELL SURVIVAL IN AML STEM/PROGENITOR CELLS. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S87). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. |
| 2010 | Powell, J. A., Thomas, D., Barry, E. F., Kok, C. H., Ma, L. Y., To, L. B., . . . Guthridge, M. A. (2010). TARGETING CELL SURVIVAL PATHWAYS IN ACUTE MYELOID LEUKEMIA. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S60). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. |
| 2008 | Thomas, D., Woodcock, J., Powell, J. A., Barry, E. F., Lopez, A. F., & Guthridge, M. A. (2008). Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia. In BLOOD Vol. 112 (pp. 1315). San Francisco, CA: AMER SOC HEMATOLOGY. WoS3 |
| 2005 | Thomas, D., Powell, J., Lee, S. H., Lopez, A. F., & Mark, G. (2005). Primary acute myeloid leukemic blasts display constitutive serine 585 phosphorylation within the 14-3-3 binding motif of the GM-CSF/IL-3 receptor required for survival signalling.. In BLOOD Vol. 106 (pp. 25A). Atlanta, GA: AMER SOC HEMATOLOGY. |
| 2005 | Powell, J. A., Thomas, D., Lee, S. H., Lopez, A. F., & Guthridge, M. A. (2005). Constitutive serine-585 phosphorylation of the GM-CSF receptor and the deregulation of survival signalling in AML blasts. In EXPERIMENTAL HEMATOLOGY Vol. 33 (pp. 74). Univ Glasgow, Glasgow, SCOTLAND: ELSEVIER SCIENCE INC. |
| 1997 | Crowe, S. M., & Lopez, A. (1997). GM-CSF and its effects on replication of HIV-1 in cells of macrophage lineage. In Journal of Leukocyte Biology Vol. 62 (pp. 41-48). VERONA, ITALY: FEDERATION AMER SOC EXP BIOL. DOI Scopus26 WoS24 Europe PMC17 |
| 1997 | Woodcock, J., McClure, B., Stomski, F., Bagley, C., & Lopez, A. (1997). The mechanism of GM-CSF receptor activation. In EXPERIMENTAL HEMATOLOGY Vol. 25 (pp. 111). CARDEN JENNINGS PUBL CO LTD. |
| 1992 | Macpherson, J. L., Lopez, A., & Krilis, S. A. (1992). Co-culture of human bone marrow cells with a mastocytosis cell strain induces mast cell/basophil differentiation. In International Archives of Allergy and Immunology Vol. 99 (pp. 346-349). CAPRI, ITALY: KARGER. DOI Scopus3 WoS2 |
| Year | Citation |
|---|---|
| 2019 | El Khawanky, N., Hughes, A., Yu, W., Taromi, S., Clarson, J., Lopez, A. F., . . . Zeiser, R. (2019). Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS4 |
| 2018 | Hunyadkurti, J., Leyton, J., Fafard Couture, L., Lacasse, V., Bonin, M. A., & Lopez, A. (2018). CD125xCNE bispecific antibody development to treat bladder cancer. Poster session presented at the meeting of Cancer research. US: American Association for Cancer Research. DOI |
| 2017 | El-Khawanky, N., Hughes, A., Yu, W., Clarson, J., Lopez, A. F., Brown, M., . . . Yong, A. (2017). CD123 Chimeric Antigen Receptor T-cells in Chronic and Acute Myeloid Leukaemia: pre-clinical in vitro studies. Poster session presented at the meeting of HAA. |
| 2013 | Van Der Wal, A., Cranmer, S., Ramshaw, H., Van der Wal, E., Schoenwaelder, M., Yuan, Y., . . . Jackson, S. (2013). 14-3-3? regulates the procoagulant function of platelets. Poster session presented at the meeting of Abstracts of the 24th Congress of the International Society on Thrombosis and Haemostasis, as published in Journal of Thrombosis and Haemostasis. Amsterdam, The Netherlands: Wiley-Blackwell. DOI |
| 2012 | Nievergall, E., White, D. L., Yong, A. S. M., Ramshaw, H. S., Busfield, S. J., Vairo, G., . . . Hiwase, D. K. (2012). Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment. Poster session presented at the meeting of BLOOD. GA, Atlanta: AMER SOC HEMATOLOGY. DOI |
| 2012 | Lim, G. E., Piske, M., Ramshaw, H. S., Guthridge, M. A., Lopez, A. F., & Johnson, J. D. (2012). 14-3-3 proteins are required for pancreatic beta cell survival and glucose homeostasis. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER. |
| 2012 | Markey, K. A., Koyama, M., Kuns, R. D., Lineburg, K. E., Wilson, Y. A., Olver, S. D., . . . MacDonald, K. P. A. (2012). Immune insufficiency after experimental transplantation is due to defective antigen presentation within dendritic cell subsets. Poster session presented at the meeting of Abstracts from the 2012 BMT Tandem Meetings, as published in Biology of Blood And Marrow Transplantation. San Diego, CA: Elsevier Science. DOI |
| 2012 | Busfield, S. J., Biondo, M., Wong, M., Ramshaw, H. S., Lee, E. M., Martin, K., . . . Nash, A. (2012). CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells. Poster session presented at the meeting of BLOOD. GA, Atlanta: AMER SOC HEMATOLOGY. DOI WoS3 |
| 2012 | Lim, G. E., Piske, M., Ramshaw, H. S., Guthridge, M. A., Lopez, A. F., & Johnson, J. D. (2012). 14-3-3ζ is required for glucose homeostasis, lipid metabolism, and adipogenesis.. Poster session presented at the meeting of MOLECULAR BIOLOGY OF THE CELL. AMER SOC CELL BIOLOGY. |
| 2011 | Sadras, T., Perugini, M., Ramshaw, H. S., Salerno, D. G., Kok, C. H., Lewis, I. D., . . . D'Andrea, R. J. (2011). IL-3 REGULATES B-CATENIN IN MYELOID CELLS AND ENFORCED EXPRESSION OF B-CATENIN REDUCES THE DEPENDENCY ON IL-3 FOR SURVIVAL. Poster session presented at the meeting of EXPERIMENTAL HEMATOLOGY. ELSEVIER SCIENCE INC. |
| 2000 | Olver, I., Vadas, M., Lopez, A., Keefe, D., Taylor, A., Brown, M., & To, L. (2000). A phase 1 study of the GM-CSF antagonist E21R. Poster session presented at the meeting of Proceedings of ASCO - Volume 19 2000. USA: American Society of Clinical Oncology. DOI |
| Year | Citation |
|---|---|
| 2022 | Owczarek, C., Lopez, A., Yip, K. H., & Tumes, D. (2022). WO2022115914, Methods for treating inflammatory skin conditions. |
| 2022 | Owczarek, C., Campbell, I., Krstevski, K., Bozinovski, S., Lopez, A., & Tumes, D. (2022). WO2022133519, Methods for treating or preventing acute respiratory distress syndrome. |
| 2017 | Lopez, A. F., Bonder, C. S., & Thompson, E. (2017). WO2017027898, Novel cancer treatment involving modulation of il-3 activity. |
| 2016 | Woodcock, J., Lopez, A., Pitson, S., Samuel, M., & Coolen, C. (2016). WO2016054680, Modulators of 14-3-3 functionality and uses thereof. |
| 2015 | Bonder, C. S., & Lopez, A. F. (2015). WO2015168750, Method of culturing cells. |
| 2015 | Lopez, A., & Schwarz, Q. (2015). WO2013086574A1, Method of treatment. |
| 2013 | Schwarz, Q., & Lopez, A. (2013). WO2013040650A1, Screening Method. |
| 2013 | Bonder, C. S., López, Á. F., & Talbo, G. H. (2013). EP2635674, Markers of endothelial progenitor cells and uses thereof. |
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Novel approaches to control mast cell function in allergic inflammation., NHMRC - Project Grant, 01/01/2017 - 31/12/2020
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Aberrant signalling in leukaemia, NHMRC - Program Grant, 01/01/2015 - 31/12/2019
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Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
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Defining the role of VEGF and vascular formation in craniofacial development, NHMRC - Project Grant, 01/01/2014 - 31/12/2017
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Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2023 | Co-Supervisor | Immunological determinants of head and neck cancer progression and metastasis, in particular the role of cancer associated fibroblasts | Master of Philosophy (Surgery) | Master | Part Time | Miss Laura Kenyon |
| 2023 | Co-Supervisor | Immunological determinants of head and neck cancer progression and metastasis, in particular the role of cancer associated fibroblasts | Master of Philosophy (Surgery) | Master | Part Time | Miss Laura Kenyon |
| 2021 | Co-Supervisor | Understanding how the epigenetic field effect exerted by cancers upon their microenvironment promotes tumour progression | Doctor of Philosophy | Doctorate | Full Time | Mrs Zahra Esmaeili |
| 2020 | Principal Supervisor | Transforming growth factor beta as a differential regulator of Beta common receptor and Interleukin 3 receptor alpha expression. | Doctor of Philosophy | Doctorate | Full Time | Mrs Sepideh Azizi Taramsary |
| 2020 | Co-Supervisor | Deciphering how airway epithelial programming and inflammation cause chronic allergic airways disease | Doctor of Philosophy | Doctorate | Part Time | Ms Anita Kral |
| 2020 | Principal Supervisor | Transforming growth factor beta as a differential regulator of Beta common receptor and Interleukin 3 receptor alpha expression. | Doctor of Philosophy | Doctorate | Full Time | Dr Sepideh Azizi Taramsary |
| 2019 | Co-Supervisor | Revealing the role of ICAM1 in breast cancer progression | - | Doctorate | Part Time | Ms Anahita Fouladzadeh |
| 2019 | Co-Supervisor | Revealing the role of ICAM1 in breast cancer progression | Doctor of Philosophy | Doctorate | Part Time | Ms Anahita Fouladzadeh |
| 2018 | Co-Supervisor | Understanding the role of 14-3-3 proteins in lung cancer initiation, progression and metastasis. | Doctor of Philosophy | Doctorate | Part Time | Mr Rhys Hamon |
| 2014 | Co-Supervisor | Regulation of vascular development in triple negative breast cancer, roles for interleukin-3 (IL-3) and inhibitor of DNA binding-1 (ID1). | - | Doctorate | Part Time | Miss Emma Thompson |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2019 - 2026 | Co-Supervisor | Revealing the role of ICAM1 in breast cancer progression | Doctor of Philosophy | Doctorate | Part Time | Mrs Anahita Fouladzadeh |
| 2014 - 2026 | Co-Supervisor | Regulation of vascular development in triple negative breast cancer, roles for interleukin-3 (IL-3) and inhibitor of DNA binding-1 (ID1). | Doctor of Philosophy | Doctorate | Part Time | Miss Emma Thompson |
| 2007 - 2012 | Principal Supervisor | Regulation of Cell Survival in Acute Myeloid Leukemia | Doctor of Philosophy | Doctorate | Full Time | Dr Daniel Thomas |
| 2006 - 2011 | Principal Supervisor | Regulation of the BH3-only protein PUMA by growth factor signalling | Doctor of Philosophy | Doctorate | Full Time | Mr Jarrod Sandow |
| 2002 - 2006 | Principal Supervisor | The Role of 14-3-3X in Cytokine Receptor Signalling | Doctor of Philosophy | Doctorate | Full Time | Mr Fernando Felquer |
| 1998 - 2008 | Principal Supervisor | The Role of ?c Subunit Phosphorylation in the Functioning of the GM-CSF/IL-3/ IL-5 Receptors | Doctor of Philosophy | Doctorate | Full Time | Ms Wendy Winnall |
| 1996 - 2017 | Principal Supervisor | Molecular Assembly of the Activated Granulocyte-Macrophage Colony-Stimulating Factor Receptor | Doctor of Philosophy | Doctorate | Part Time | Mrs Barbara Jean McClure |
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