Angel Lopez
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Professor Angel F Lopez AO, MBBS, PhD, FRCPA, FAHMS, FAA
Head, Human Immunology, SA Pathology
Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia
Qualifications: MB BS School of Medicine (Argentina), PhD (London), Fellow of the Royal College of Pathologists.
My major interest is understanding how growth factors or hormones produced by the immune system regulate inflammation and some cancers. I have authored more than 250 research publications and my work has led to significant insights and breakthrough discoveries in understanding how growth factors and their receptors work in health and in diseases such as allergic inflammation and some cancers. This has led to new paradigms of cell signalling and has underpinned the development of novel antibodies as diagnostic tools as well as potential therapeutics. My group has been supported continuously by the NHMRC since 1987 and also receives support from the pharmaceutical industry.
Cytokines are protein hormones that regulate survival, proliferation and differentiation of many cell types including haematopoietic cells and also control a range of immune functions and inflammatory responses. Cytokine receptors transmit signals between the extracellular environment and the cell’s internal machinery and cause cells to respond in a variety of ways such as maintenance of viability, proliferation, differentiation or activation of functional responses. Abnormalities of cytokine receptor signalling may lead to enhanced cell viability or survival, and increased cell proliferation, hallmarks of cancer while prolonged or inappropriate cell activation is a feature of inflammatory disease. The main focus of my research is to understand the mechanism of cytokine receptor activation and the impact of these cytokines in health and disease. This work reveals universal biological rules and enables the development of new drugs for diseases such as leukaemia, asthma and arthritis.
My laboratory studies a family of cytokines known as the beta common (Bc) family, so named because they share a receptor subunit, Bc. The Bc family includes granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5). The research programs in my laboratory include structural biology approaches to elucidate structural and functional properties of the Bc receptor complexes. To date we have solved structures for the GM-CSF and IL-3 receptor complexes, identifying novel mechanisms of receptor assembly, activation and signalling. We are using this knowledge to develop novel ligands that can selectively activate Bc receptors to promote cell differentiation but not cell activation and have developed antibodies that block c cytokine function or target leukaemic cells for destruction as part of a long-term collaboration with CSL Limited.
Recently we have developed a novel strategy of patient treatment with Primary myelofibrosis initiated by mutations in Calreticulin. This work was published (Tvorogov et al, Embo Rports 2022) this year and has initiated some collaboration with pharmaceutical industry. Primary myelofibrosis is severe myeloproliferative neoplasm that affects both young and older adults, and is characterised by marrow fibrosis and chronic inflammatory symptoms with a 5-year survival of less than 50%. Our translational application of research is helping to develop new therapeutic agents for use in a range of disease settings.
Area of Research
Cytokine Receptors, Cell Signalling, Cancer, Structural Biology, Allergic Inflammation, New Therapeutics
Project Title
Cytokine Receptor Laboratory
Overall Project Descriptions
Cytokines are soluble factors that regulate the production and function of haematopoietic and other cells, play a role in leukaemia and solid cancers, and modulate inflammatory responses. Their receptors transmit signals between the extracellular environment and the cell’s internal machinery and cause cells to respond in a variety of ways such as adherence to substrates, proliferation, differentiation and migrate through blood and lymphatic vessels to other parts of the body. Abnormalities of cytokine receptor signalling may lead to enhanced cell survival and increased cell proliferation, hallmarks of cancer, while prolonged or inappropriate cell activation is a feature of inflammatory diseases. The focus of my research is to understand how cytokines and their receptors regulate cellular signalling and how their signalling impacts on health and disease.
My laboratory studies a family of cytokines that includes granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5), as well as certain cancer-derived soluble factors that influence their immediate microenvironment. The research programs in my laboratory are designed to decipher how these cytokines and other soluble factors interact with their cell surface receptors, and how they signal normally and in cancer and in inflammatory conditions using multiple approaches and biological systems. To date we have solved structures for the GM-CSF and IL-3 receptor complexes, and have identified novel mechanisms of receptor assembly and activation that shed light into how these receptors signal normally and when they are dysregulated in disease. We are using this knowledge to understand the basis for disease initiation and progression, and to develop novel therapeutics that can block undesirable functions or that by promoting biased signalling reveal a new biology.
For available projects please see Professor Lopez’s Researcher Profile under “My Research”
Projects available for Third Year; Honours; HDR; Masters; Mphil
Maximum Number of Students: 3
Category: Wet Laboratory
Research Areas: Cytokine Receptors, Cell Signalling, Cancer, Structural Biology, Allergic Inflammation, New Therapeutics
Research Project 1 – Dr Tim Hercus
Title: Development of novel ligands that selectively activate Bc receptor signalling
Description: We have recently solved the structure of the IL-3 receptor signalling complex and with collaborators have developed novel peptide scaffolds that generate subtly altered receptor arrangements. This project will study the function of novel ligands of the IL-3 receptor to characterise molecules that selectively activate the receptor and act as biased agonists. This will involve expression and purification of peptide ligands and assessment of their function on cell lines and primary cells using a range of techniques including flow cytometry, phosphoprotein quantitation and transcriptomic analysis.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
Email: angel.lopez@sa.gov.au
Research Project 2 – Dr Tim Hercus
Title: Characterisation of the structural and functional mechanisms of IL-5 receptor activation.
Description: We have solved structures for the ternary GM-CSF and IL-3 receptor signalling complexes and characterised their novel mechanism of activation however it remains unclear the extent to which IL-5, which uniquely exists as a dimer, follows this paradigm. To understand the conserved and cytokine-specific features of cytokine signalling in this family, we will study the structure and function of the IL-5 receptor complex in collaboration with colleagues at Bio21 in Melbourne. This will involve expression and purification of receptor subunits and cytokine, structure determination of protein complexes and assessment of conserved or unique structural interactions through in silico methods such as molecular dynamics and functional studies of mutant components in cell lines in bioassays and FRET experiments as well as phosphoprotein and transcriptomic analysis.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
Email: angel.lopez@sa.gov.au
Research Project 3 – Dr Winnie Kan
Title: Establishing the transcriptional programs that determine stem cell fate in haemopoiesis and leukaemia
Description: Although cytokines stimulate multiple functions of haematopoietic cells such as cell survival, proliferation and differentiation, the mechanisms governing these cell fate decisions are not understood. We have recently discovered that the IL-3 receptor assembles into two forms upon IL-3 binding, activating distinct signalling and gene expression programs to direct different biological outcomes: the hexameric form of the receptor promotes stemness while the dodecameric form induces cell differentiation. Importantly, we found that leukaemia stem cells (which are responsible for the initiation of acute myeloid leukaemia and its relapse) preferentially activate hexamer signalling to maintain their stemness and self-renewal properties. In this project, we will: i) dissect the signalling and gene expression programs induced by different IL-3 receptor assemblies that drive cell fate decisions in normal haemopoiesis and leukaemia and ii) determine the regulation of these transcriptional programs by a critical network of small non-coding RNAs called microRNAs. This project will involve a variety of biological and cell signalling assays by flow cytometry to study stemness and cell differentiation and transcriptomic analyses using our unique haematopoietic stem and progenitor cell models.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
Research Project 4 – Dr Denis Tvorogov
Title: Neoepitope-directed strategy to selectively eliminate pathogenic clones in young adults with myelofibrosis
Description: We have developed a novel immunotherapeutic approach (a blocking monoclonal anti-neoepitope antibody, 4D7) that has high potential to change the treatment course for patients with myelofibrosis expressing a highly recurrent mutation (CALR, the 2nd most common genetic driver and more common in younger adults < 50 years) that was previously considered “undruggable”. This study will involve haemopoietic assays, cell signalling analysis and sophisticated biochemical approaches.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
Email: angel.lopez@sa.gov.au
Research Project 5 – Dr Marina Kochetkova
Title: How can we target tumour microenvironment to treat breast cancer?
Description: Breast cancer is the leading cause of cancer-related death in women. Finding effective drugs for metastatic breast cancer, preventing disease recurrence, and reversing chemotherapy resistance are the current challenges that must be solved to reduce mortality. Recent discoveries by us and others have led to an appreciation that cancers, including breast tumours, must be considered not just as a collection of cells but as complex systems, components of which interact with each other via multifaceted and plastic signalling networks. Cancer associated fibroblasts (CAFs) are a major cellular component of the tumour stroma and they have been attributed multiple tumour-promoting roles in breast and other malignancies. However, origin, specific functions, and molecular regulators of CAFs are still, to the large degree undiscovered and will be the subject of this research project. We have established a variety of in vitro and in vivo breast cancer models that will enable cutting edge research into unravelling the role of CAFs in the generating cancer-enabling tumour midcontinent.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
Email: angel.lopez@sa.gov.au
Research Project 6 – Dr Damon Tumes and A/Prof Harshita Pant
Title: Defining novel inflammatory cell types in asthma and other chronic airway diseases
Description: Many people with asthma have elevated numbers of eosinophils in their airway tissue that are thought to cause airway damage and in severe cases remodelling. Our new data shows that eosinophils in the airways are transcriptionally and functionally diverse and indicates that targeting all eosinophils may not be the best way to manage eosinophilic disease. In this project, enabled by our close collaborations with Adelaide ENT and respiratory specialists, single cell transcriptomics will be used to define previously unrecognised heterogeneity within human airway eosinophils and spatial transcriptomics will be used to map how these cells interact with other inflammatory and structural cells in the airway.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
E: angel.lopez@sa.gov.au
Research Project Start: Semester 1 and 2
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Education
Date Institution name Country Title 1981 National Institute for Medical Research, Mill Hill, University of London United Kingdom PhD 1975 University of Rosario (School of Medicine) Argentina MB BS
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Journals
Year Citation 2024 Wang, H., Yip, K. H., Keam, S. P., Vlahos, R., Nichol, K., Wark, P., . . . Tumes, D. J. (2024). Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade. Journal of Allergy and Clinical Immunology, 153(3), 672-683.e6.
2024 Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 13 pages.
2024 Johan, M. Z., Pyne, N. T., Kolesnikoff, N., Poltavets, V., Esmaeili, Z., Woodcock, J. M., . . . Samuel, M. S. (2024). Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis.. The Journal of investigative dermatology, S0022-202X(24)00276-8.
2023 Yip, K. H., Chao, J., Coolen, C., Pant, H., Kral, A., Smith, W., . . . Tumes, D. J. (2023). IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ. Journal of Allergy and Clinical Immunology, 152(3), 725-735.
Scopus1 WoS1 Europe PMC12023 Kan, W. L., Dhagat, U., Hercus, T. R., Kaufmann, K. B., Nero, T. L., Zeng, A. G. X., . . . Lopez, A. (2023). Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia. Cancer Discovery, 13(8), 1922-1947.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. Blood Cancer Discovery, 4(5), 352-364.
Scopus12023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Methods from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2023 Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.
2022 Yip, K. H., McKenzie, D., Ramshaw, H. S., Chao, J., McClure, B. J., Raquet, E., . . . Tumes, D. J. (2022). Targeting the human βc Receptor inhibits contact dermatitis in a transgenic mouse model. The Journal of Investigative Dermatology, 142(4), 1103-1113.
Scopus3 WoS2 Europe PMC22022 Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., . . . Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death and Disease, 13(2), 11 pages.
Scopus9 WoS5 Europe PMC32022 Tvorogov, D., Thompson-Peach, C. A. L., Foßelteder, J., Dottore, M., Stomski, F., Onnesha, S. A., . . . Lopez, A. F. (2022). Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody. EMBO Reports, 23(4), e52904-1-e52904-12.
Scopus9 WoS8 Europe PMC102022 Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., . . . Vinuesa, C. G. (2022). TLR7 gain-of-function genetic variation causes human lupus. Nature, 605(7909), 349-356.
Scopus180 WoS111 Europe PMC1222022 Fung, N. H., Wang, H., Vlahos, R., Wilson, N., Lopez, A. F., Owczarek, C. M., & Bozinovski, S. (2022). Targeting the human β<inf>c</inf> receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure. Respirology, 27(8), 617-629.
Scopus4 WoS3 Europe PMC12022 Pant, H., Hercus, T. R., Tumes, D. J., Yip, K. H., Parker, M. W., Owczarek, C. M., . . . Huston, D. P. (2022). Translating the biology of β common receptor-engaging cytokines into clinical medicine. Journal of Allergy and Clinical Immunology, 151(2), 324-344.
Scopus3 WoS1 Europe PMC12021 Begley, C. G., Ashton, M., Baell, J., Bettess, M., Brown, M. P., Carter, B., . . . Sullivan, M. (2021). Drug repurposing: misconceptions, challenges, and opportunities for academic researchers. Sci Transl Med, 13(612), 1-13.
Scopus52 WoS34 Europe PMC382021 El Khawanky, N., Hughes, A., Yu, W., Myburgh, R., Matschulla, T., Taromi, S., . . . Zeiser, R. (2021). Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia. Nat Commun, 12(1), 6436-1-6436-20.
Scopus47 WoS30 Europe PMC342021 Kan, W. L., Cheung Tung Shing, K. S., Nero, T. L., Hercus, T. R., Tvorogov, D., Parker, M. W., & Lopez, A. F. (2021). Messing with βc: a unique receptor with many goals. Seminars in Immunology, 54, 101513-1-101513-14.
Scopus2 WoS1 Europe PMC12021 De Silva, A. P., Schembri, M. A., Sarah, A. H., Chao, J., Yip, K. H., Cildir, G., . . . Pant, H. (2021). Short-term Oral Steroids Significantly Improves Chronic Rhinosinusitis Without Nasal Polyps. Laryngoscope, 131(10), E2618-E2626.
Scopus3 WoS2 Europe PMC12021 Cildir, G., Yip, K. H., Pant, H., Tergaonkar, V., Lopez, A. F., & Tumes, D. J. (2021). Understanding mast cell heterogeneity at single cell resolution. Trends in Immunology, 42(6), 523-535.
Scopus19 WoS15 Europe PMC152020 Yip, K. H., Wilson, N. J., Pant, H., Brown, C. L., Busfield, S., Ng, M., . . . Owczarek, C. M. (2020). Anti-βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model. Allergy, 75(2), 475-478.
Scopus9 WoS7 Europe PMC32020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.
Scopus45 WoS40 Europe PMC282020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908.
Scopus4 WoS4 Europe PMC32020 Baroni, M. L., Sanchez Martinez, D., Gutierrez Aguera, F., Roca Ho, H., Castella, M., Zanetti, S., . . . Menendez, P. (2020). 41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo. Journal for ImmunoTherapy of Cancer, 8(1), 11 pages.
Scopus35 WoS31 Europe PMC292020 Diallo, K., Dussault, S., Noll, C., Lopez, A. F., Rivard, A., Carpentier, A. C., & Lim, G. E. (2020). 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Molecular Metabolism, 41, 101052.
Scopus1 Europe PMC12019 Cheung Tung Shing, K., Broughton, S., Nero, T., Gillinder, K., Ilsley, M., Ramshaw, H., . . . Dhagat, U. (2019). Author Correction: EPO does not promote interaction between the erythropoietin and beta-common receptors (Scientific Reports, (2018), 8, 1, (12457), 10.1038/s41598-018-29865-x). Scientific Reports, 9(1), 7851.
2019 Cañete, P. F., Sweet, R. A., Gonzalez-Figueroa, P., Papa, I., Ohkura, N., Bolton, H., . . . Vinuesa, C. G. (2019). Regulatory roles of IL-10-producing human follicular T cells. The Journal of Experimental Medicine, 216(8), 1843-1856.
Scopus54 WoS36 Europe PMC382019 Cildir, G., Toubia, J., Yip, K. H., Zhou, M., Pant, H., Hissaria, P., . . . Tergaonkar, V. (2019). Genome-wide analyses of chromatin state in human mast cells reveal molecular drivers and mediators of allergic and inflammatory diseases. Immunity, 51(5), 949-965.
Scopus32 WoS34 Europe PMC232019 Gartlan, K. H., Koyama, M., Lineburg, K. E., Chang, K., Ensbey, K. S., Kuns, R. D., . . . Hill, G. R. (2019). Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract. Blood Advances, 3(19), 2859-2865.
Scopus19 WoS14 Europe PMC132018 Hercus, T., Kan, W., Broughton, S., Tvorogov, D., Ramshaw, H., Sandow, J., . . . Lopez, A. (2018). Role of the β common (βc) family of cytokines in health and disease. Cold Spring Harbor Perspectives in Biology, 10(6), a028514.
Scopus31 WoS21 Europe PMC152018 Woodcock, J., Goodwin, K., Sandow, J., Coolen, C., Perugini, M., Webb, A., . . . Carver, J. (2018). Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity. Journal of Biological Chemistry, 293(1), 89-99.
Scopus18 WoS15 Europe PMC72018 Tvorogov, D., Thomas, D., Liau, N. P. D., Dottore, M., Barry, E. F., Lathi, M., . . . Lopez, A. F. (2018). Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis. Science Advances, 4(11), 1-12.
Scopus37 WoS34 Europe PMC302018 Cheung Tung Shing, K. S., Broughton, S. E., Nero, T. L., Gillinder, K., Ilsley, M. D., Ramshaw, H., . . . Dhagat, U. (2018). EPO does not promote interaction between the erythropoietin and beta-common receptors. Scientific Reports, 8(1), 12457-1-12457-16.
Scopus20 WoS17 Europe PMC152018 Dhagat, U., Hercus, T. R., Broughton, S. E., Nero, T. L., Cheung Tung Shing, K. S., Barry, E. F., . . . Parker, M. W. (2018). The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. mAbs, 10(7), 1018-1029.
Scopus7 WoS6 Europe PMC42018 Broughton, S., Hercus, T., Nero, T., Kan, W., Barry, E., Dottore, M., . . . Parker, M. (2018). A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nature Communications, 9(1), 386-1-386-15.
Scopus25 WoS23 Europe PMC132018 Paquette, M., Beaudoin, S., Tremblay, M. A., Jean, S., Lopez, A. F., Lecomte, R., . . . Leyton, J. V. (2018). NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and in Vivo Tumor-Targeting Properties in a Bladder Cancer Model. Bioconjugate Chemistry, 29(4), 1352-1363.
Scopus8 WoS6 Europe PMC82017 Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., . . . Jackson, S. (2017). Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature communications, 8(1), 16125.
Scopus1 WoS12017 Wittwer, N. L., Brumatti, G., Marchant, C., Sandow, J. J., Pudney, M. K., Dottore, M., . . . Ramshaw, H. S. (2017). High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression. Blood Advances, 1(15), 1067-1079.
Scopus24 WoS20 Europe PMC162017 Cildir, G., Pant, H., Lopez, A., & Tergaonkar, V. (2017). The transcriptional program, functional heterogeneity, and clinical targeting of mast cells. Journal of Experimental Medicine, 214(9), 2491-2506.
Scopus76 WoS68 Europe PMC502017 Paquette, M., Vilera-Perez, L. G., Beaudoin, S., Ekindi-Ndongo, N., Boudreaut, P. L., Bonin, M. A., . . . Leyton, J. V. (2017). Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. OncoImmunology, 6(10), 11 pages.
Scopus15 WoS15 Europe PMC122017 Powell, J., Lewis, A., Zhu, W., Toubia, J., Pitman, M., Wallington-Beddoe, C., . . . Pitson, S. (2017). Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.. Blood, 129(6), 771-782.
Scopus67 WoS59 Europe PMC482017 Hughes, A., Clarson, J., Gargett, T., Yu, W., Brown, M. P., Lopez, A. F., . . . Yong, A. S. M. (2017). Comment on “KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study”. Leukemia Research, 55, 55-57.
Scopus3 WoS3 Europe PMC22017 Ng, Y., Sorvina, A., Bader, C., Weiland, F., Lopez, A., Hoffmann, P., . . . Brooks, D. (2017). Proteome analysis of Drosophila mutants identifies a regulatory role for 14-3-3ε in metabolic pathways. Journal of Proteome Research, 16(5), 1976-1987.
Scopus1 WoS1 Europe PMC12016 Gargett, T., Christo, S. N., Hercus, T. R., Abbas, N., Singhal, N., Lopez, A. F., & Brown, M. P. (2016). GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 5(12), 12 pages.
Scopus33 WoS27 Europe PMC182016 Yip, K., Kolesnikoff, N., Hauschild, N., Biggs, L., Lopez, A., Galli, S., . . . Grimbaldeston, M. (2016). The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nature Communications, 7(1), 13198-1-13198-14.
Scopus22 WoS23 Europe PMC122016 Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., . . . Jackson, S. P. (2016). 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7(1), 12862-1-12862-15.
Scopus47 WoS45 Europe PMC282016 Nievergall, E., Reynolds, J., Kok, C., Watkins, D., Biondo, M., Busfield, S., . . . White, D. (2016). TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy. Leukemia, 30(6), 1263-1272.
Scopus38 WoS32 Europe PMC232016 Vu, T., Austin, R., Kuhn, C. P., Bruedigam, C., Song, A., Guignes, S., . . . Lane, S. W. (2016). Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling. Haematologica, 101(3), e77-e80.
Scopus5 WoS5 Europe PMC52016 Lim, G. E., Piske, M., Lulo, J. E., Ramshaw, H. S., Lopez, A. F., & Johnson, J. D. (2016). Ywhaz/14-3-3ζ deletion improves glucose tolerance through a GLP-1-dependent mechanism. Endocrinology, 157(7), 2649-2659.
Scopus24 WoS21 Europe PMC162016 Ebert, L. M., Tan, L. Y., Johan, M. Z., Min, K. K. M., Cockshell, M. P., Parham, K. A., . . . Bonder, C. S. (2016). A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis. Angiogenesis, 19(4), 463-486.
Scopus31 WoS27 Europe PMC222016 Broughton, S. E., Hercus, T. R., Nero, T. L., King-Scott, J., Lopez, A. F., Parker, M. W., . . . Gorman, M. A. (2016). Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. Structure, 24(8), 1271-1281.
Scopus38 WoS33 Europe PMC262016 Panousis, C., Dhagat, U., Edwards, K. M., Rayzman, V., Hardy, M. P., Braley, H., . . . Owczarek, C. M. (2016). CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. mAbs, 8(3), 436-453.
Scopus35 WoS29 Europe PMC172015 Broughton, S. E., Nero, T. L., Dhagat, U., Kan, W. L., Hercus, T. R., Tvorogov, D., . . . Parker, M. W. (2015). The βc receptor family - Structural insights and their functional implications. Cytokine, 74(2), 247-258.
Scopus62 WoS52 Europe PMC402015 Lee, E., Yee, D., Busfield, S., McManus, J., Cummings, N., Vairo, G., . . . Lock, R. (2015). Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice. Haematologica, 100(7), 914-926.
Scopus48 WoS45 Europe PMC322015 Moldenhauer, L., Cockshell, M., Frost, L., Parham, K., Tvorogov, D., Tan, L., . . . Bonder, C. (2015). Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties. Stem Cell Research, 14(3), 380-395.
Scopus16 WoS14 Europe PMC92015 Woodcock, J., Coolen, C., Goodwin, K., Baek, D., Bittman, R., Samuel, M., . . . Lopez, A. (2015). Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics. Oncotarget, 6(16), 14522-14536.
Scopus29 WoS25 Europe PMC182015 He, S., Busfield, S., Ritchie, D., Hertzberg, M., Durrant, S., Lewis, I., . . . Roberts, A. (2015). A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia. Leukemia & Lymphoma, 56(5), 1406-1415.
Scopus92 WoS85 Europe PMC732015 Xu, X., Jaehne, E., Greenberg, Z., McCarthy, P., Saleh, E., Parish, C., . . . Schwarz, Q. (2015). 14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders. Scientific Reports, 5(1), 12434-1-12434-15.
Scopus35 WoS33 Europe PMC272015 Lim, G., Albrecht, T., Piske, M., Sarai, K., Lee, J., Ramshaw, H., . . . Johnson, J. (2015). 14-3-3ζ coordinates adipogenesis of visceral fat. Nature Communications, 6(1), 7671-1-7671-17.
Scopus46 WoS41 Europe PMC342015 Jaehne, E., Ramshaw, H., Xu, X., Saleh, E., Clark, S., Schubert, K., . . . Baune, B. (2015). In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders. Pharmacology Biochemistry and Behavior, 138, 1-8.
Scopus12 WoS10 Europe PMC72015 Kular, J., Scheer, K., Pyne, N., Allam, A., Pollard, A., Magenau, A., . . . Samuel, M. (2015). A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis. Developmental Cell, 35(6), 759-774.
Scopus28 WoS22 Europe PMC192014 Toyo-oka, K., Wachi, T., Hunt, R. F., Baraban, S. C., Taya, S., Ramshaw, H., . . . Wynshaw-Boris, A. (2014). 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. The Journal of Neuroscience, 34(36), 12168-12181.
Scopus90 WoS84 Europe PMC722014 Yip, K., Kolesnikoff, N., Yu, C., Hauschild, N., Taing, H., Biggs, L., . . . Grimbaldeston, M. (2014). Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation. Journal of Allergy and Clinical Immunology, 133(5), 1356-1379.
Scopus95 WoS84 Europe PMC612014 Hercus, T., Broughton, S., Hardy, M., Nero, T., Wilson, N., Parker, M., & Lopez, A. (2014). Unexpected mechanisms of action for a cytokine receptor-blocking antibody.. Molecular & cellular oncology, 1(4), e969129.
Scopus1 WoS1 Europe PMC12014 Broughton, S., Hercus, T., Hardy, M., McClure, B., Nero, T., Dottore, M., . . . Lopez, A. (2014). Dual mechanism of Interleukin-3 receptor blockade by an anti-cancer antibody. Cell Reports, 8(2), 410-419.
Scopus45 WoS39 Europe PMC292014 Broughton, S., Hercus, T., Nero, T., Dhagat, U., Owczarek, C., Hardy, M., . . . Parker, M. (2014). Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362. Acta Crystallographica Section F: Structural Biology Communications, 70(3), 358-361.
Scopus8 WoS7 Europe PMC42014 Busfield, S., Biondo, M., Wong, M., Ramshaw, H., Lee, E., Ghosh, S., . . . Nash, A. (2014). Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC. Leukemia, 28(11), 2213-2221.
Scopus116 WoS108 Europe PMC812014 Sadras, T., Perugini, M., Kok, C., Iarossi, D., Heatley, S., Brumatti, G., . . . D'Andrea, R. (2014). Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia. Journal of Leukocyte Biology, 96(1), 83-91.
Scopus14 WoS15 Europe PMC82014 Nievergall, E., Ramshaw, H., Yong, A., Biondo, M., Busfield, S., Vairo, G., . . . Hiwase, D. (2014). Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells. Blood, 123(8), 1218-1228.
Scopus83 WoS77 Europe PMC622013 Ramshaw, H., Xu, X., Jaehne, E., McCarthy, P., Greenberg, Z., Saleh, E., . . . Schwarz, Q. (2013). Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction. Translational Psychiatry, 3(e327), 1-10.
Scopus26 WoS24 Europe PMC172013 Lim, Y., Wright, J., Attema, J., Gregory, P., Bert, A., Smith, E., . . . Goodall, G. (2013). Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. Journal of Cell Science, 126(10), 2256-2266.
Scopus167 WoS154 Europe PMC1282013 Thomas, D., Powell, J., Green, B., Barry, E., Ma, Y., Woodcock, J., . . . Guthridge, M. (2013). Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology, 11(3), 1-14.
Scopus19 WoS16 Europe PMC172013 Thomas, D., Powell, J., Vergez, F., Segal, D., Nguyen, N., Baker, A., . . . Guthridge, M. (2013). Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood, 122(5), 738-748.
Scopus51 WoS51 Europe PMC372013 Hercus, T., Dhagat, U., Kan, W., Broughton, S., Nero, T., Perugini, M., . . . Lopez, A. (2013). Signalling by the βc family of cytokines. Cytokine & Growth Factor Reviews, 24(3), 189-201.
Scopus79 WoS68 Europe PMC552013 Kim, S., Karasuyama, H., Lopez, A., Ouyang, W., Li, X., Le Gros, G., & Min, B. (2013). IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses. Immune Network, 13(6), 249-256.
Europe PMC92013 Tettamanti, S., Marin, V., Pizzitola, I., Magnani, C., Giordano Attianese, G., Cribioli, E., . . . Biagi, E. (2013). Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. British Journal of Haematology, 161(3), 389-401.
Scopus170 WoS166 Europe PMC1422013 Hercus, T., Barry, E., Dottore, M., McClure, B., Webb, A., Lopez, A., . . . Murphy, J. (2013). High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties. PLoS ONE, 8(8), e74376-e74376-8.
Scopus14 WoS12 Europe PMC112012 Appleby, S., Cockshell, M., Pippal, J., Thompson, E., Barrett, J., Tooley, K., . . . Bonder, C. (2012). Characterization of a distinct population of circulating human non-adherent endothelial forming cells and their recruitment via intercellular adhesion molecule-3. PLoS One, 7(11), 1-15.
Scopus19 WoS19 Europe PMC142012 Broughton, S., Dhagat, U., Hercus, T., Nero, T., Grimbaldeston, M., Bonder, C., . . . Parker, M. (2012). The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunological Reviews, 250(1), 277-302.
Scopus192 WoS168 Europe PMC1282012 Broughton, S., Hercus, T., Lopez, A., & Parker, M. (2012). Cytokine receptor activation at the cell surface. Current Opinion in Structural Biology, 22(3), 350-359.
Scopus27 WoS27 Europe PMC232012 Markey, K., Koyama, M., Kuns, R., Lineburg, K., Wilson, Y., Olver, S., . . . MacDonald, K. (2012). Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets. Blood, 119(24), 5918-5930.
Scopus34 WoS28 Europe PMC242012 Cheah, P., Ramshaw, H., Thomas, P., Toyo-oka, K., Xu, X., Martin, S., . . . Schwarz, Q. (2012). Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency. Molecular Psychiatry, 17(4), 451-466.
Scopus86 WoS81 Europe PMC702012 Hercus, T., Broughton, S., Ekert, P., Ramshaw, H., Perugini, M., Grimbaldeston, M., . . . Lopez, A. (2012). The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors, 30(2), 63-75.
Scopus58 WoS55 Europe PMC432012 Sandow, J., Jabbour, A., Condina, M., Daunt, C., Stomski, F., Green, B., . . . Ekert, P. (2012). Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death and Differentiation, 19(4), 633-641.
Scopus27 WoS23 Europe PMC222012 Pitman, M., Woodcock, J., Lopez, A., & Pitson, S. (2012). Molecular targets of FTY720 (Fingolimod). Current Molecular Medicine, 12(10), 1207-1219.
Scopus60 WoS58 Europe PMC452011 Yu, C., Fedoric, B., Anderson, P. H., Lopez, A. F., & Grimbaldeston, M. A. (2011). Vitamin D<sub>3</sub> signalling to mast cells: A new regulatory axis. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 43(1), 41-46.
WoS212011 Shandala, T., Woodcock, J., Ng, Y., Biggs, L., Skoulakis, E., Brooks, D., & Lopez, A. (2011). Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity. Journal of Cell Science, 124(13), 2165-2174.
Scopus42 WoS40 Europe PMC312011 Yu, C., Fedoric, B., Anderson, P., Lopez, A., & Grimbaldeston, M. (2011). Vitamin D₃ signalling to mast cells: A new regulatory axis. International Journal of Biochemistry & Cell Biology, 43(1), 41-46.
Scopus26 Europe PMC142010 Lopez, A., Hercus, T., Ekert, P., Littler, D., Guthridge, M., Thomas, D., . . . Parker, M. (2010). Molecular basis of cytokine receptor activation. IUBMB Life, 62(7), 509-518.
Scopus59 WoS54 Europe PMC382010 Hiwase, D., White, D., Powell, J., Saunders, V., Zrim, S., Frede, A., . . . Hughes, T. (2010). Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors. Leukemia, 24(4), 771-778.
Scopus48 WoS42 Europe PMC332010 Kim, S., Prout, M., Ramshaw, H., Lopez, A., LeGros, G., & Min, B. (2010). Cutting edge: Basophils are transiently recruited into the draining lymph nodes during Helminth infection via IL-3, but infection-induced Th2 immunity can develop without Basophil lymph node recruitment or IL-3. Journal of Immunology, 184(3), 1143-1147.
Scopus124 WoS113 Europe PMC922010 Woodcock, J., Ma, Y., Coolen, C., Pham, D., Jones, C., Lopez, A., & Pitson, S. (2010). Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cellular Signalling, 22(9), 1291-1299.
Scopus63 WoS61 Europe PMC482010 Perugini, M., Brown, A., Salerno, D., Booker, G., Stojkoski, C., Hercus, T., . . . D'Andrea, R. (2010). Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit. Blood, 115(16), 3346-3353.
Scopus54 WoS47 Europe PMC322010 Biggs, L., Yu, C., Fedoric, B., Lopez, A., Galli, S., & Grimbaldeston, M. (2010). Evidence that vitamin D-3 promotes mast cell-dependent reduction of chronic UVB-nduced skin pathology in mice. Journal of Experimental Medicine, 207(3), 455-463.
Scopus102 WoS95 Europe PMC682009 Powell, J., Thomas, D., Barry, E., Kok, C., McClure, B., Tsykin, A., . . . Guthridge, M. (2009). Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. Blood, 114(23), 4859-4870.
Scopus52 WoS49 Europe PMC412009 Hercus, T., Thomas, D., Guthridge, M., Ekert, P., King-Scott, J., Parker, M., & Lopez, A. (2009). The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood, 114(7), 1289-1298.
Scopus251 WoS235 Europe PMC1742009 Jin, L., Lee, E., Ramshaw, H., Busfield, S., Peoppl, A., Wilkinson, L., . . . Lock, R. (2009). Monoclonal antibody-mediated targeting of CD123, IL-3 receptor α chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell, 5(1), 31-42.
Scopus442 WoS395 Europe PMC3332009 Barry, E., Felquer, F., Powell, J., Biggs, L., Stomski, F., Urbani, A., . . . Guthridge, M. (2009). 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. Journal of Biological Chemistry, 284(18), 12080-12090.
Scopus33 WoS30 Europe PMC242009 Jabbour, A., Heraud, J., Daunt, C., Kaufmann, T., Sandow, J., O'Reilly, L., . . . Ekert, P. (2009). Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death and Differentiation, 16(4), 555-563.
Scopus65 WoS64 Europe PMC572009 Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., . . . Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117.
Scopus37 WoS34 Europe PMC302008 Hansen, G., Hercus, T., Mc Clure, B., Stomski, F., Dottore, M., Powell, J., . . . Parker, M. (2008). The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell, 134(3), 496-507.
Scopus254 WoS231 Europe PMC1822008 Hansen, G., Hercus, T., Xu, Y., Lopez, A., Parker, M., & McKinstry, W. (2008). Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 64(Part 8), 711-714.
Scopus8 WoS5 Europe PMC22008 Mu, F., Andrews, R., Arthur, J., Munday, A., Cranmer, S., Jackson, S., . . . Berndt, M. (2008). A functional 14-3-3ζ-independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Blood, 111(9), 4580-4587.
Scopus41 WoS35 Europe PMC282008 Asquith, K., Ramshaw, H., Hansbro, P., Beagley, K., Lopez, A., & Foster, P. (2008). The IL-3/IL-5/GM-CSF common beta receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. Journal of Immunology, 180(2), 1199-1206.
Scopus106 WoS103 Europe PMC682007 Ramshaw, H., Guthridge, M., Stomski, F., Barry, E., Ooms, L., Mitchell, C., . . . Lopez, A. (2007). The Shc-binding site of the β[c] subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood, 110(10), 3582-3590.
Scopus19 WoS16 Europe PMC122007 Guthridge, M. A., & Lopez, A. F. (2007). Phosphotyrosine/phosphoserine binary switches: A new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?. Biochemical Society Transactions, 35(2), 250-252.
Scopus9 WoS9 Europe PMC92006 Holland, J., Kochetkova, M., Akekawatchai, C., Dottore, M., Lopez, A., & McColl, S. (2006). Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells. Cancer Research, 66(8), 4117-4124.
Scopus82 WoS81 Europe PMC622006 Guthridge, M., Powell, J., Barry, E., Stomski, F., Mc Clure, B., Ramshaw, H., . . . Lopez, A. (2006). Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. EMBO Journal, 25(3), 479-489.
Scopus68 WoS65 Europe PMC532005 Ma, Y., Pitson, S., Hercus, T., Murphy, J., Lopez, A., & Woodcock, J. (2005). Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. Journal of Biological Chemistry, 280(28), 26011-26017.
Scopus63 WoS58 Europe PMC442004 Guthridge, M., Barry, E., Felquer, F., Mc Clure, B., Stomski, F., Ramshaw, H., & Lopez, A. (2004). The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kB and induction of bcl-2. Blood, 103(3), 820-827.
Scopus65 WoS62 Europe PMC462004 Thomas, D., Vadas, M., & Lopez, A. (2004). Regulation of haematopoiesis by growth factors - emerging insights and therapies. Expert Opinion on Biological Therapy, 4(6), 869-879.
Scopus17 WoS16 Europe PMC142003 Mc Clure, B., Hercus, T., Cambareri, B., Woodcock, J., Bagley, C., Howlett, G., & Lopez, A. (2003). Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex. Blood, 101(4), 1308-1315.
Scopus35 WoS33 Europe PMC232003 Olayioye, M., Guthridge, M., Stomski, F., Lopez, A., Visvader, J., & Lindeman, G. (2003). Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins. Journal of Biological Chemistry, 278(35), 32929-32935.
Scopus24 WoS22 Europe PMC132003 Woodcock, J., Murphy, J., Stomski, F., Berndt, M., & Lopez, A. (2003). The dimeric versus monomeric status of 14-3-3z is controlled by phosphorylation of Ser58 at the dimer interface. Journal of Biological Chemistry, 278(38), 36323-36327.
Scopus143 WoS134 Europe PMC1102002 Ramshaw, H., Lopez, A., & Bardy, P. (2002). The development of cytokine receptor antagonists as potential therapeutic agents for the myeloproliferative disorders. Current Pharmaceutical Design, 8(5), 357-368.
Scopus1 Europe PMC12002 Ramshaw, H., Bardy, P., Lee, M., & Lopez, A. (2002). Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. Experimental Hematology, 30(10), 1124-1131.
Scopus39 WoS35 Europe PMC272002 Olver, I., Hercus, T., Lopez, A., Vadas, M., Somogyi, A., Doyle, I., . . . Wigley, P. (2002). A phase I study of the GM-CSF antagonist E21R. Cancer Chemotherapy and Pharmacology, 50(3), 171-178.
Scopus8 WoS8 Europe PMC62001 Mc Clure, B., Stomski, F., Lopez, A., & Woodcock, J. (2001). Perverted responses of the human granulocyte-macrophage colony-stimulating factor receptor in mouse cell lines due to cross-species b-subunit association. Blood, 98(10), 3165-3168.
Scopus6 WoS6 Europe PMC62001 Bagley, C., Woodcock, J., Guthridge, M., Stomski, F., & Lopez, A. (2001). Structural and functional hot spots in cytokine receptors. International Journal of Hematology, 73(3), 299-307.
Europe PMC42001 Mc Clure, B., Woodcock, J., Harrison-Findik, D., Lopez, A., & D'Andrea, R. (2001). GM-CSF binding to its receptor induces oligomerisation of the common beta-subunit. Cytokine, 13(4), 240-243.
Scopus6 WoS6 Europe PMC22001 Ramshaw, H. S., Woodcock, J. M., McClure, B. J., Hercus, T. R., Lopez, A. F., & Bagley, C. J. (2001). New approaches in the treatment of asthma. Immunology and Cell Biology, 79(2), 154-159.
Scopus29 WoS26 Europe PMC172000 Le, F., Stomski, F., Woodcock, J., Lopez, A., & Gonda, T. (2000). The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity. Journal of Biological Chemistry, 275(7), 5124-5130.
Scopus21 WoS19 Europe PMC152000 Guthridge, M., Stomski, F., Barry, E., Winnall, W., Woodcock, J., Mc Clure, B., . . . Lopez, A. (2000). Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. Molecular Cell, 6(1), 99-108.
Scopus69 WoS67 Europe PMC482000 Rossjohn, J., McKinstry, W., Woodcock, J., Mc Clure, B., Hercus, T., Parker, M., . . . Bagley, C. (2000). Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common b-chain bound to an antagonist. Blood, 95(8), 2491-2498.
Scopus51 WoS45 Europe PMC372000 Mulhern, T., Lopez, A., D'Andrea, R., Gaunt, C., Vandeleur, L., Vadas, M., . . . Bagley, C. (2000). The solution structure of the cytokine-binding domain of the common -chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. Journal of Molecular Biology, 297(4), 989-1001.
Scopus26 WoS26 Europe PMC162000 Stomski, F. C., Guthridge, M. A., Barry, E. F., Winnall, W., Woodcock, J. M., Lopez, A. F., & Ramshaw, H. (2000). Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. EXPERIMENTAL HEMATOLOGY, 28(7), 119.
2000 Kedzierska, K., Maerz, A., Warby, T., Jaworowski, A., Chan, H. T., Mak, J., . . . Crowe, S. (2000). Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages. AIDS, 14(12), 1739-1748.
Scopus50 WoS44 Europe PMC352000 Kedzierska, K., Mak, J., Mijch, A., Cooke, I., Rainbird, M., Roberts, S., . . . Crowe, S. M. (2000). Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1- infected monocytes/macrophages in vitro and in vivo. Journal of Infectious Diseases, 181(1), 390-394.
Scopus63 WoS56 Europe PMC401999 Ramshaw, H. S., Bardy, P., & Lopez, A. F. (1999). Role of E21R, a specific GM-CSF antagonist, on chronic myelomonocytic leukaemia. EXPERIMENTAL HEMATOLOGY, 27(7), 82. 1999 Haman, A., Cadieux, C., Wilkes, B., Hercus, T., Lopez, A., Clark, S., & Hoang, T. (1999). Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly. Journal of Biological Chemistry, 274(48), 34155-34163.
Scopus22 WoS21 Europe PMC101999 Jiang, X., Lopez, A., Holyoake, T., Eaves, A., & Eaves, C. (1999). Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 96(22), 12804-12809.
Scopus205 WoS196 Europe PMC1311999 Sun, Q., Jones, K., McClure, B., Cambareri, B., Zacharakis, B., Iversen, P., . . . Lopez, A. (1999). Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulting factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors. Blood, 94(6), 1943-1951.
Scopus60 WoS50 Europe PMC321999 Stomski, F., Dottore, M., Winnall, W., Guthridge, M., Woodcock, J., Bagley, C., . . . Lopez, A. (1999). Identification of a 14-3-3 binding sequence in the common B chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF. Blood, 94(6), 1933-1942.
Scopus45 WoS38 Europe PMC251999 Mulhern, T., Bagley, C., Gaunt, C., Lopez, A., Vadas, M., D'Andrea, R., & Booker, G. (1999). Letter to the Editor: 1H and 15N chemical shift assignments for domain 4 of the common β-chain of the IL-3, IL-5 and GM-CSF receptors. Journal of Biomolecular NMR, 14(3), 281-282.
Scopus1 WoS1 Europe PMC11999 Woodcock, J., Bagley, C., & Lopez, A. (1999). The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications. International Journal of Biochemistry and Cell Biology, 31(-), 1017-1025.
Scopus18 WoS13 Europe PMC101999 Woodcock, J., Bagley, C., & Lopez, A. (1999). The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications.. Int J Biochem Cell Biol, 31(10), 1017-1025.
1998 Guthridge, M. A., Stomski, F. C., Thomas, D., Woodcock, J. M., Bagley, C. J., Berndt, M. C., & Lopez, A. F. (1998). Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors. Stem Cells, 16(5), 301-313.
Scopus157 WoS144 Europe PMC1001998 Stomski, F. C., Woodcock, J. M., Zacharakis, B., Bagley, C. J., Sun, Q., & Lopez, A. F. (1998). Identification of a cys motif in the common β chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors. Journal of Biological Chemistry, 273(2), 1192-1199.
Scopus53 WoS50 Europe PMC291998 Hoang, T., Rajotte, D., Cadieux, C., Haitian, A., Wilkes, B. C., Clark, S. C., . . . Lopez, A. (1998). Crucial role of the residue ARG280 at the F-G loop of the human GM-CSF receptor a chain for ligand recognition. Experimental Hematology, 26(8), 720. 1998 Woodcock, J., McClure, B., Zacharakis, B., Slomski, F., & Lopez, A. (1998). Determining the biological significance of the preformed GM-CSF receptor. Experimental Hematology, 26(8), 720. 1998 Kedzierska, K., Rainbird, M. A., Lopez, A. F., & Crowe, S. M. (1998). Effect of GM-CSF on HIV-1 replication in monocytes/macrophages in vivo and in vitro: A review. Veterinary Immunology and Immunopathology, 63(1-2), 111-121.
Scopus18 WoS15 Europe PMC141998 Ramshaw, H. S., Iversen, P., & Lopez, A. F. (1998). E21R, a human GM-CSF antagonist, eradicates engrafted leukemic cells from immunodeficient mice. Experimental Hematology, 26(8), 745. 1998 Yamada, T., Sun, Q., Zeibecoglou, K., Bungre, J., North, J., Kay, A. B., . . . Robinson, D. S. (1998). IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor α-subunit, and common β-subunit expression by peripheral leukocytes and blood dendritic cells. Journal of Allergy and Clinical Immunology, 101(5), 677-682.
Scopus52 WoS48 Europe PMC291997 Iversen, P. O., Lewis, I. D., Turczynowicz, S., Hasle, H., Niemeyer, C., Schmiegelow, K., . . . Lopez, A. F. (1997). Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice. Blood, 90(12), 4910-4917.
Scopus50 WoS43 Europe PMC231997 Murray, J., Barbara, J. A. J., Dunkley, S. A., Lopez, A. F., VanOstade, X., Condliffe, A. M., . . . Chilvers, E. R. (1997). Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. BLOOD, 90(7), 2772-2783.
WoS257 Europe PMC1421997 Meng, Q., Ying, S., Iversen, P., Lopez, A. F., Kay, A. B., & Robinson, D. S. (1997). E21R, a mutant of human granulocyte-macrophage colony-stimulating factor (GM-CSF), selectively inhibits GM-CSF-enhanced eosinophil degranulation.. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 99(1), 497. 1997 Woodcock, J., McClure, B., Stomski, F., Baglev, C., & Lopez, A. (1997). The mechanism of GM-CSF receptor activation. Experimental Hematology, 25(8), 760. 1997 Vadas, M. A., Lopez, A. F., & Shannon, M. F. (1997). Human interleukin-3(IL-3) variants and their use to promote or antagonize IL-3-mediated processes. Biotechnology Advances, 15(3-4), 773.
1997 Woodcock, J. M., Bagley, C. J., & Lopez, A. F. (1997). Receptors of the cytokine superfamily: Mechanisms of activation and involvement in disease. Bailliere's Clinical Haematology, 10(3), 507-524.
Scopus2 WoS2 Europe PMC11997 Iversen, P. O., Robinson, D., Ying, S., Meng, Q., Kay, A. B., Clark-Lewis, I., & Lopez, A. F. (1997). The GM-CSF analogue E21R induces apoptosis of normal and activated eosinophils. American Journal of Respiratory and Critical Care Medicine, 156(5), 1628-1632.
Scopus23 WoS18 Europe PMC61997 Woodcock, J. M., McClure, B. J., Stomski, F. C., Elliott, M. J., Bagley, C. J., & Lopez, A. F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM- CSF, interleukin-3, or interleukin-5. Blood, 90(8), 3005-3017.
Scopus52 WoS51 Europe PMC341997 Bagley, C., Lopez, A., & Vadas, M. (1997). New frontiers for IL-5.. The Journal of allergy and clinical immunology, 99(6 Pt 1), 725-728.
Europe PMC221997 Bagley, C. J., Woodcock, J. M., Stomski, F. C., & Lopez, A. F. (1997). The structural and functional basis of cytokine receptor activation: Lessons from the common β subunit of the granulocyte-macrophage colony- stimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood, 89(5), 1471-1482.
Scopus163 WoS152 Europe PMC921997 Iversen, P., Hart, P., Bonder, C., & Lopez, A. (1997). Interleukin (IL)-10, but not IL-4 or IL-13, inhibits cytokine production and growth in juvenile myelomonocytic leukemic cells.. Cancer Research, 57(3), 476-480.
Scopus14 WoS15 Europe PMC81997 Bagley, C., Woodcock, J., Stomski, F., & Lopez, A. (1997). The structural and functional basis of cytokine receptor activation: lessons from the commonb subunit of the GM-CSF, IL-3 and IL-5 receptors.. Blood, 89, 1471-1482. 1997 Barry, S., Korpelainen, E., Sun, Q., Stomski, F., Moretti, P., Wakao, H., . . . Goodall, G. (1997). Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function.. Blood, 89(3), 842-852.
Scopus51 WoS52 Europe PMC271997 Murray, J., Barbara, J., Dunkley, S., Lopez, A., Van Ostade, X., Condliffe, A., . . . Chilvers, E. (1997). Regulation of neutrophil apoptosis by TNF-a: requirement for TNFR55 and TNFR75 for induction of apoptois in vitro.. Blood, 90(7), 2772-2783.
Scopus2771997 Iversen, P., Lewis, I., Turczynowicz, S., Hasle, H., Niemeyer, C., Schmiegelow, K., . . . Lopez, A. (1997). Inhibition of GM-CSF prevents dissemination and induces remission of human juvenile myelomonocytic leukemia in engrafted immunodeficient mice.. Blood, 90(12), 4910-4917. 1997 Woodcock, J., McClure, F., Stomski, F., Elliott, M., Bagley, C., & Lopez, A. (1997). The human GM-CSF receptor exists as a preformed receptor complex that can be activated by GM-CSF, IL-3 or IL-5. Blood, 90, 3005-3017. 1997 Iversen, P., Hercus, T., Zacharakis, B., Woodcock, J., Stomski, F., Kumar, S., . . . Lopez, A. (1997). The apoptosis-inducing granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R functions through specific regions of the heterodimeric GM-CSF receptor, and requires interleukin-1 beta converting enzyme-like proteases.. Journal of Biological Chemistry, 272(15), 9877-9883.
Scopus12 WoS12 Europe PMC71997 Bagley, C., Lopez, A., & Vadas, M. (1997). New frontiers for IL-5. Journal of Allergy and Clinical Immunology, 99(Number 6 Part 1), 725-728.
Scopus40 WoS371997 Rajotte, D., Cadieux, C., Haman, A., Wilkes, B., Clark, S., Hercus, T., . . . Hoang, T. (1997). Crucial role of the residue at the F'-G' loop of the human GM-CSF receptor a chain for ligand recognition.. Journal of Experimental Medicine, 185(11), 1939-1950.
Scopus31 WoS30 Europe PMC161997 Kocketkova, M., Iversen, P., Lopez, A., & Shannon, M. (1997). Deoxyribo-nucleic acid triplex formation inhibits granulocyte-macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells.. Journal of Clinical Investigation, 99(12), 3000-3008.
Scopus47 WoS45 Europe PMC221996 Qiyu, S., Woodcock, J., Stomski, F., Bagley, C., Goodall, G., Smith, W., . . . Lopez, A. (1996). Monoclonal antibody 7G3 recognises the N-terminal domain of the human IL-3 receptor and functions as a specific IL-3 receptor antagonist. Blood, 87(1), 83-92.
Scopus97 WoS95 Europe PMC631996 Jenkins, B., Bagley, C., Woodcock, J., Lopez, A., & Gonda, T. (1996). Interacting residues ion the extracellular region of the common β subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation. Journal of Biological Chemistry, 271(47), 29707-29714.
Scopus21 WoS21 Europe PMC151996 Macardle, P., Chen, Z., Shih, C., Huang, C., Weedon, H., Sun, Q., . . . Zola, H. (1996). Characterization of human leucocytes bearing the IL-3 receptor. Cellular Immunology, 168(1), 59-68.
Scopus9 WoS10 Europe PMC71996 Bagley, C. J., Phillips, J., Cambareri, B., Vadas, M. A., & Lopez, A. F. (1996). A discontinuous eight-amine acid epitope in human interleukin-3 binds the α-chain of its receptor. Journal of Biological Chemistry, 271(50), 31922-31928.
Scopus18 WoS18 Europe PMC61996 Woodcock, J. M., Bagley, C. J., Zacharakis, B., & Lopez, A. F. (1996). A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL- 5 receptor common β-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. Journal of Biological Chemistry, 271(42), 25999-26006.
Scopus87 WoS89 Europe PMC531996 Iversen, P. O., Rodwell, R. L., Pitcher, L., Taylor, K. M., & Lopez, A. F. (1996). Inhibition of proliferation and induction of apoptosis in juvenile myelomonocytic leukemic cells by the granulocyte-macrophage colony- stimulating factor analogue E21R. Blood, 88(7), 2634-2639.
Scopus42 WoS38 Europe PMC121996 Stomski, F. C., Sun, Q., Bagley, C. J., Woodcock, J., Goodall, G., Andrews, R. K., . . . Lopez, A. F. (1996). Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor α- and β-chain heterodimerization, which is required for receptor activation but not high-affinity binding. Molecular and Cellular Biology, 16(6), 3035-3046.
Scopus72 WoS70 Europe PMC381996 Iversen, P. O., To, L. B., & Lopez, A. F. (1996). Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R. Proceedings of the National Academy of Sciences of the United States of America, 93(7), 2785-2789.
Scopus26 WoS25 Europe PMC131996 Khew-Goodall, Y., Butcher, C. M., Litwin, M. S., Newlands, S., Korpelainen, E. I., Noack, L. M., . . . Vadas, M. A. (1996). Chronic expression of P-selectin on endothelial cells stimulated by the T-Cell cytokine, interleukin-3. Blood, 87(4), 1432-1438.
Scopus81 WoS72 Europe PMC501996 Korpelainen, E. I., Gamble, J. R., Vadas, M. A., & Lopez, A. F. (1996). IL-3 receptor expression, regulation and function in cells of the vasculature. Immunology and Cell Biology, 74(1), 1-7.
Scopus51 WoS49 Europe PMC441996 Till, K. J., Burthem, J., Lopez, A., & Cawley, J. C. (1996). Granulocyte-macrophage colony-stimulating factor receptor: Stage- specific expression and function on late B cells. Blood, 88(2), 479-486.
Scopus30 WoS31 Europe PMC171996 Woodcock, J. M., Baglev, C. J., Zacharakis, B., & Lopez, A. F. (1996). Tyrosine<sup>421</sup> in the GM-CSF, il-3 and IL-5 receptor common β chain is necessary and sufficient for binding and signalling by all three ligands. FASEB Journal, 10(6), 1795. 1996 Barbara, I. A. J., Smith, W. B., VanOstade, X., Fiers, W., Vadas, M. A., & Lopez, A. F. (1996). The proinflammatory and cytotoxic activities of TNF-alpha.. KIDNEY INTERNATIONAL, 50(4), 1394. 1996 Barbara, J. A. J., Van Ostade, X., & Lopez, A. F. (1996). Tumour necrosis factor-alpha (TNF-α): The good, the bad and potentially very effective. Immunology and Cell Biology, 74(5), 434-443.
Scopus104 WoS99 Europe PMC641996 Sun, Q., Woodcock, J. M., Bagley, C. J., Jones, K., DAndrea, R., & Lopez, A. F. (1996). A monoclonal antibody (MoAb) to the human IL-3, GM-CSF and IL-5 receptor common beta-chain (beta(c)) neutralises the binding and function of all three ligands.. BLOOD, 88(10), 2170.
WoS11995 Till, K. J., Burthem, J., Lopez, A. F., & Cawley, J. C. (1995). Late B cells express receptors for GM-CSF, and the cytokine inhibits B-cell movement.. BLOOD, 86(10), 90. 1995 Korpelainen, E. I., Gamble, J. R., Smith, W. B., Dottore, M., Vadas, M. A., & Lopez, A. F. (1995). Interferon-γ upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production. Blood, 86(1), 176-182.
Scopus39 WoS39 Europe PMC211995 Korpelainen, E., Gamble, J., Smith, W., Dottore, M., Vadas, M., & Lopez, A. (1995). Interferon gamma upregulates IL-3 receptor expression in human endothelial cells and synergises with IL-3 in stimulating MHC class II expression and cytokine production. Blood, 86, 176-182. 1995 Bagley, C., Woodcock, J., Hercus, T., Shannon, M., & Lopez, A. (1995). The interaction of GM-CSF and IL-3 with the common beta chain of their receptors. Journal of Leukocyte Biology, 57(5), 739-746.
Scopus27 WoS24 Europe PMC111995 Smith, W., Guida, L., Qiuy, S., Korpelainen, E., van den Hueven, C., Gillis, D., . . . Lopez, A. (1995). Neutrophils activated by granulocyte-macrophage colony-stimulating factor express receptors for interleukin-3 which mediate class II expression. Blood, 86(10), 3938-3944.
Scopus66 WoS60 Europe PMC391994 Woodcock, J. M., Zacharakis, B., Plaetinck, G., Bagley, C. J., Qiyu, S., Hercus, T. R., . . . Lopez, A. F. (1994). Three residues in the common β chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO Journal, 13(21), 5175-5185.
Scopus101 Europe PMC481994 Hercus, T. R., Bagley, C. J., Cambareri, B., Dottore, M., Woodcock, J. M., Vadas, M. A., . . . Lopez, A. F. (1994). Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5838-5842.
Scopus104 WoS102 Europe PMC471994 Hercus, T. R., Cambareri, B., Dottore, M., Woodcock, J., Bagley, C. J., Vadas, M. A., . . . Lopez, A. F. (1994). Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the α- and β-chains of its receptor. Blood, 83(12), 3500-3508.
Scopus67 WoS66 Europe PMC351994 Barbara, J. A. J., Smith, W. B., Gamble, J. R., Van Ostade, X., Vandenabeele, P., Tavernier, J., . . . Lopez, A. F. (1994). Dissociation of TNF-α cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-α mutants. EMBO Journal, 13(4), 843-850.
Scopus145 WoS145 Europe PMC761994 BAGLEY, C. J., WOODCOCK, J. M., BARRY, S. C., PHILLIPS, J. A., DOTTORE, M., CAMBARERI, B., . . . LOPEZ, A. F. (1994). INTERACTION OF THE FIRST AND 4TH HELICES OF INTERLEUKIN-3 WITH THE ALPHA-CHAINS AND BETA-CHAINS OF ITS RECEPTOR. JOURNAL OF CELLULAR BIOCHEMISTRY, 17.
WoS11994 WOODCOCK, J. M., ZACHARAKIS, B., PLAETINCK, G., BAGLEY, C. J., QIYU, S., HERCUS, T. R., & LOPEZ, A. F. (1994). 3 RESIDUES IN THE COMMON BETA-CHAIN OF THE HUMAN GM-CSF, IL-3 AND IL-5 RECEPTORS ARE ESSENTIAL FOR GM-CSF AND IL-5 BUT NOT IL-3 HIGH-AFFINITY BINDING AND INTERACT WITH GLU21 OF GM-CSF. EMBO JOURNAL, 13(21), 5176-5185.
WoS1031994 Barry, S. C., Bagley, C. J., Phillips, J., Dottore, M., Cambareri, B., Moretti, P., . . . Lopez, A. F. (1994). Two contiguous residues in human interleukin-3, Asp 21 and Glu 22, selectively interact with the α- and β-chains of its receptor and participate in function. Journal of Biological Chemistry, 269(11), 8488-8492.
Scopus76 WoS76 Europe PMC351994 Vadas, M., Lopez, A., Gamble, J., Khew-Goodall, Y., Smith, W., Bernard, C., . . . Hercus, T. (1994). Cytokines and allergy. The Journal of Allergy and Clinical Immunology, 94(6 PART 2), 1289-1293.
Scopus13 WoS12 Europe PMC101994 Kazazi, F., Chang, J., Lopez, A., Vadas, M., & Cunningham, A. L. (1994). Interleukin 4 and human immunodeficiency virus stimulate LFA-1-ICAM-1-mediated aggregation of monocytes and subsequent giant cell formation. Journal of General Virology, 75(10), 2795-2802.
Scopus36 WoS32 Europe PMC231994 D'Andrea, R., Rayner, J., Moretti, P., Lopez, A., Goodall, G. J., Gonda, T. J., & Vadas, M. (1994). A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity. Blood, 83(10), 2802-2808.
Scopus53 WoS56 Europe PMC241993 Till, K. J., Lopez, A., Slupsky, J., & Cawley, J. C. (1993). C‐fms protein expression by B‐cells, with particular reference to the hairy cells of hairy‐cell leukaemia. British Journal of Haematology, 83(2), 223-231.
Scopus27 WoS30 Europe PMC81993 BAGLEY, C. J., PHILLIPS, J. A., DOTTORE, M., CAMBARERI, B., & LOPEZ, A. F. (1993). INTERACTION OF THE 1ST AND 4TH HELICES OF INTERLEUKIN-3 WITH THE ALPHA-CHAIN AND BETA-CHAIN OF ITS RECEPTOR. JOURNAL OF LEUKOCYTE BIOLOGY, 69. 1993 LOPEZ, A. F., BAGLEY, C., DANDREA, R., GOODALL, G., HERCUS, T., SHANNON, M. F., . . . WOODCOCK, J. (1993). THE STRUCTURAL BASIS FOR THE INTERACTION OF HEMATOPOIETIC GROWTH-FACTORS WITH THEIR RECEPTORS. JOURNAL OF LEUKOCYTE BIOLOGY, 108. 1993 Weich, N. S., Tullai, J., Guido, E., McMahon, M., Jolliffe, L. K., Lopez, A. F., . . . Rosen, J. (1993). Interleukin-3/erythropoietin fusion proteins: In vitro effects on hematopoietic cells. Experimental Hematology, 21(5), 647-655.
Scopus12 WoS13 Europe PMC71993 LOPEZ, A. F., SHANNON, M. F., GOODALL, G., BARRY, S., HERCUS, T., PHILLIPS, J., . . . VADAS, M. A. (1993). IDENTIFICATION OF RESIDUES IN IL-3 AND GM-CSF INTERACTING WITH THE ALPHA-CHAIN AND BETA-CHAIN OF THEIR RECEPTORS. JOURNAL OF CELLULAR BIOCHEMISTRY, 79. 1993 GOODALL, G. J., BAGLEY, C. J., DANDREA, R. J., VADAS, M. A., & LOPEZ, A. F. (1993). INTERACTIONS BETWEEN HUMAN IL-3 AND ITS RECEPTOR. JOURNAL OF CELLULAR BIOCHEMISTRY, 75. 1993 Korpelainen, E. I., Gamble, J. R., Smith, W. B., Goodall, G. J., Qiyu, S., Woodcock, J. M., . . . Lopez, A. F. (1993). The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor α and potentiates interleukin 8 secretion and neutrophil transmigration. Proceedings of the National Academy of Sciences of the United States of America, 90(23), 11137-11141.
Scopus69 WoS68 Europe PMC401993 Kremer, E., Baker, E., D'Andrea, R. J., Slim, R., Phillips, H., Moretti, P. A. B., . . . Goodall, G. J. (1993). A cytokine receptor gene cluster in the X-Y pseudoautosomal region?. Blood, 82(1), 22-28.
Scopus41 WoS36 Europe PMC211993 Goodall, G. J., Bagley, C. J., Vadas, M. A., & Lopez, A. F. (1993). A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands. Growth Factors, 8(2), 87-97.
Scopus77 WoS79 Europe PMC461992 Lopez, A. F., Shannon, M. F., Barry, S., Phillips, J. A., Cambareri, B., Dottore, M., . . . Vadas, M. A. (1992). A human interleukin 3 analog with increased biological and binding activities. Proceedings of the National Academy of Sciences of the United States of America, 89(24), 11842-11846.
Scopus45 WoS41 Europe PMC211992 Lopez, A. F., Elliott, M. J., Woodcock, J., & Vadas, M. A. (1992). GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells. Immunology Today, 13(12), 495-500.
Scopus138 WoS143 Europe PMC781992 Bardy, P. G., Lopez, A. F., Moore, S., Park, L. S., Vadas, M. A., & Shannon, M. F. (1992). Human GM-CSF receptor α-chain gene is highly polymorphic but not rearranged in AML. Leukemia, 6(9), 893-897.
Scopus5 WoS4 Europe PMC31992 Hardy, S. J., Haylock, D. N., Lopez, A. F., & Murray, A. W. (1992). Examination of the role of the proteolytically-activated form of protein kinase C in the differentiation of human haemopoietic cells. Differentiation, 50(3), 189-202.
Scopus4 WoS51992 Lopez, A. F., Frances Shannon, M., Hercus, T., Nicola, N. A., Cambareri, B., Dottore, M., . . . Vadas, M. A. (1992). Residue 21 of human granulocyte-macrophage colonystimulating factor is critical for biological activity and for high but not low affinity binding. EMBO Journal, 11(3), 909-916.
Scopus108 WoS107 Europe PMC551992 Lopez, A. F., Shannon, M. F., Chia, M. M., Park, L., & Vadas, M. A. (1992). Regulation of human eosinophil production and function by interleukin-5.. Immunology series, 57, 549-571.
Scopus17 Europe PMC61992 Elliott, M. J., Moss, J., Dottore, M., Park, L. S., Vadas, M. A., & Lopez, A. F. (1992). Differential binding of IL-3 and GM-CSF to human monocytes. Growth Factors, 6(1), 15-29.
Scopus14 WoS15 Europe PMC61992 Kazazi, F., Mathijs, J. M., Chang, J., Malafiej, P., Lopez, A., Dowton, D., . . . Cunningham, A. L. (1992). Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages. Journal of General Virology, 73(4), 941-949.
Scopus44 WoS49 Europe PMC311991 PARK, L. S., WILLIAMS, D. E., LOPEZ, A. F., & LARSEN, A. (1991). HUMAN INTERLEUKIN-3 RECEPTOR - STRUCTURE AND FUNCTION. EXPERIMENTAL HEMATOLOGY, 19(6), 458. 1991 Stewart, A. G., Harris, T., De Nichilo, M., & Lopez, A. F. (1991). Involvement of leukotriene B<inf>4</inf> and platelet-activating factor in cytokine priming of human polymorphonuclear leucocytes. Immunology, 72(2), 206-212.
Scopus21 WoS30 Europe PMC141991 Lopez, A. F., Vadas, M. A., Woodcock, J. M., Milton, S. E., Lewis, A., Elliott, M. J., . . . Park, L. S. (1991). Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. Journal of Biological Chemistry, 266(36), 24741-24747.
Scopus120 WoS127 Europe PMC651991 Elliott, M. J., Gamble, J. R., Park, L. S., Vadas, M. A., & Lopez, A. F. (1991). Inhibition of human monocyte adhesion by interleukin-4. Blood, 77(12), 2739-2745.
Scopus45 WoS49 Europe PMC211991 Ryan, G. R., Milton, S. E., Lopez, A. F., Bardy, P. G., Vadas, M. A., & Shannon, M. F. (1991). Human interleukin-3 mRNA accumulation is controlled at both the transcriptional and posttranscriptional level. Blood, 77(6), 1195-1202.
Scopus29 WoS33 Europe PMC141991 DeNichilo, M. O., Stewart, A. G., Vadas, M. A., & Lopez, A. F. (1991). Granulocyte-macrophage colony-stimulating factor is a stimulant of platelet-activating factor and superoxide anion generation by human neutrophils. Journal of Biological Chemistry, 266(8), 4896-4902.
Scopus31 WoS40 Europe PMC211991 Vadas, M. A., Lopez, A. F., Gamble, J. R., & Elliot, M. J. (1991). Role of colony-stimulating factors in leucocyte responses to inflammation and infection. Current Opinion in Immunology, 3(1), 97-104.
Scopus11 WoS12 Europe PMC91990 Lopez, A. F., Eglinton, J. M., Lyons, A. B., Tapley, P. M., To, L. B., Park, L. S., . . . Vadas, M. A. (1990). Human Interleukin‐3 inhibits the binding of granulocyte‐macrophage colony‐stimulating factor and interleukin‐5 to basophils and strongly enhances their functional activity. Journal of Cellular Physiology, 145(1), 69-77.
Scopus113 WoS123 Europe PMC611990 Gamble, J. R., Rand, T. H., Lopez, A. F., Clark-Lewis, I., & Vadas, M. A. (1990). Heterogeneity of recombinant granulocyte-macrophage colony-stimulating factor-mediated enhancement of neutrophil adherence to endothelium. Experimental Hematology, 18(8), 897-902.
Scopus11 WoS13 Europe PMC61990 Elliott, M. J., Vadas, M. A., Cleland, L. G., Gamble, J. R., & Lopez, A. F. (1990). IL-3 and granulocyte-macrophage colony-stimulating factor stimulate two distinct phases of adhesion in human monocytes. Journal of Immunology, 145(1), 167-176.
Scopus81 WoS86 Europe PMC441990 Atkinson, Y. H., Murray, A. W., Krilis, S., Vadas, M. A., & Lopez, A. F. (1990). Human tumour necrosis factor-alpha (TNF-α) directly stimulates arachidonic acid release in human neutrophils. Immunology, 70(1), 82-87.
Scopus46 WoS54 Europe PMC341990 Krissansen, G. W., Elliott, M. J., Lucas, C. M., Stomski, F. C., Berndt, M. C., Cheresh, D. A., . . . Burns, G. F. (1990). Identification of a novel integrin β subunit expressed on cultured monocytes (macrophages): Evidence that one α subunit can associate with multiple β subunits. Journal of Biological Chemistry, 265(2), 823-830.
Scopus87 WoS95 Europe PMC481990 Lopez, A. F., Lyons, A. B., Eglinton, J. M., Park, L. S., To, L. B., Clark, S. C., & Vadas, M. A. (1990). Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils. The Journal of Allergy and Clinical Immunology, 85(1 PART 1), 99-102.
Scopus30 WoS34 Europe PMC181990 Stewart, A. G., Harris, T., de Nicholo, M., & Lopez, A. F. (1990). Intracellular platelet-activating factor in endotoxin and cytokine-primed polymorphonuclear leukocytes. European Journal of Pharmacology, 183(4), 1130.
1989 Spitalnik, P. F., Spitalnik, S. L., Danley, J. M., Lopez, A. F., Vadas, M. A., Civin, C. I., & Ginsburg, V. (1989). Carbohydrate-specific monoclonal antibodies bind to human granulocytes and stimulate antibody-dependent cellular cytotoxicity. Archives of Biochemistry and Biophysics, 271(1), 168-176.
Scopus6 WoS6 Europe PMC41989 Phillips, J. A., Lopez, A. F., Milton, S. E., Vadas, M. A., & Shannon, M. F. (1989). Synthesis and expression of the gene encoding human interleukin-3. Gene, 84(2), 501-507.
Scopus6 WoS6 Europe PMC31989 Elliott, M. J., Vadas, M. A., Eglinton, J. M., Park, L. S., To, L. B., Cleland, L. G., . . . Lopez, A. F. (1989). Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes. Blood, 74(7), 2349-2359.
Scopus132 WoS147 Europe PMC711989 Gamble, J. R., Elliott, M. J., Jaipargas, E., Lopez, A. F., & Vadas, M. A. (1989). Regulation of human monocyte adherence by granulocyte-macrophage colony-stimulating factor. Proceedings of the National Academy of Sciences of the United States of America, 86(18), 7169-7173.
Scopus67 WoS75 Europe PMC351989 Lopez, A. F., Eglinton, J. M., Gillis, D., Park, L. S., Clark, S., & Vadas, M. A. (1989). Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils. Proceedings of the National Academy of Sciences of the United States of America, 86(18), 7022-7026.
Scopus112 WoS123 Europe PMC531989 Jin, B., Lopez, A. F., Gillis, S., Juttner, C. A., Vadas, M. A., & Burns, G. F. (1989). Human interleukin 4 regulates the phenotype of lymphocytes generated during mixed lymphocyte culture and inhibits the IL-2-induced development of LAK function in normal and leukaemic cells. Leukemia Research, 13(4), 297-305.
Scopus5 WoS3 Europe PMC21988 Lopez, A. F., Dyson, P. G., To, L. B., Elliott, M. J., Milton, S. E., Russell, J. A., . . . Vadas, M. A. (1988). Recombinant human interleukin-3 stimulation of hematopoiesis in humans: Loss of responsiveness with differentiation in the neutrophilic myeloid series. Blood, 72(5), 1797-1804.
Scopus79 WoS98 Europe PMC451988 Ferrante, A., Carter, R. F., Lopez, A. F., Rowen-Kelly, B., Hill, N. L., & Vadas, M. A. (1988). Depression of immunity to Naegleria fowleri in mice by selective depletion of neutrophils with a monoclonal antibody. Infection and Immunity, 56(9), 2286-2291.
Scopus22 WoS23 Europe PMC171988 Atkinson, Y. H., Lopez, A. F., Marasco, W. A., Lucas, C. M., Wong, G. G., Burns, G. F., & Vadas, M. A. (1988). Recombinant human ganulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils. Immunology, 64(3), 519-525.
Scopus58 WoS72 Europe PMC361988 Atkinson, Y. H., Marasco, W. A., Lopez, A. F., & Vadas, M. A. (1988). Recombinant human tumor necrosis factor-α. Regulation of N-formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils. Journal of Clinical Investigation, 81(3), 759-765.
Scopus144 WoS194 Europe PMC1001988 Simmers, R. N., Smith, J., Shannon, M. F., Wong, G., Lopez, A. F., Baker, E., . . . Vadas, M. A. (1988). Localization of the human G-CSF gene to the region of a breakpoint in the translocation typical of acute promyelocytic leukemia. Human Genetics, 78(2), 134-136.
Scopus7 WoS8 Europe PMC61988 Rand, T. H., Lopez, A. F., Gamble, J. R., & Vadas, M. A. (1988). Nedocromil sodium and cromolyn (Sodium cromoglycate) selectively inhibit antibody-dependent granulocyte-media ted cytotoxicity. International Archives of Allergy and Immunology, 87(2), 151-158.
Scopus21 WoS30 Europe PMC171988 Lopez, A. F., Sanderson, C. J., Gamble, J. R., Campbell, H. D., Young, I. G., & Vadas, M. A. (1988). Recombinant human interleukin 5 is a selective activator of human eosinophil function. Journal of Experimental Medicine, 167(1), 219-224.
Scopus850 WoS896 Europe PMC5381988 SIMMERS, R. N., WEBBER, L. M., BAKER, E. G., SMITH, J., SHANNON, M. F., LOPEZ, A. F., . . . SUTHERLAND, G. R. (1988). LOCALIZATION OF THE G-CSF GENE TO 17Q11.2-]Q21, PROXIMAL TO THE BREAKPOINT IN THE T(15-17) OF ACUTE PROMYELOCYTIC LEUKEMIA. AUSTRALIAN PAEDIATRIC JOURNAL, 24(1), 96. 1988 Emery, P., Lopez, A. F., Burns, G. F., & Vadas, M. A. (1988). Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes that reflect activation. Annals of the Rheumatic Diseases, 47(1), 34-39.
Scopus33 WoS46 Europe PMC301988 Clark-Lewis, I., Lopez, A. F., To, L. B., Vadas, M. A., Schrader, J. W., Hood, L. E., & Kent, S. B. H. (1988). Structure-function studies of human granulocyte-macrophage colony-stimulating factor: Identification of residues required for activity. Journal of Immunology, 141(3), 881-889.
Scopus64 WoS72 Europe PMC311988 VADAS, M. A., LOPEZ, A. F., SHANNON, M. F., EGLINTON, L., TO, L. B., EGLINTON, J., & RAND, T. H. (1988). HUMAN GM-CSF MUTANTS REVEAL DISSOCIATION BETWEEN ACTIVATION OF MATURE CELLS AND STIMULATION OF PROGENITORS MYELOID CELLS. LYMPHOKINE RESEARCH, 7(3), 291.
WoS21988 LOPEZ, A. F., TO, L. B., DYSON, P. G., RUSSELL, J. A., MILTON, S. A., YANG, Y. C., . . . VADAS, M. A. (1988). RECOMBINANT HUMAN INTERLEUKIN-3 STIMULATION OF HEMATOPOIESIS IN MAN - SELECTIVE LOSS OF RESPONSIVENESS OF NEUTROPHILIC GRANULOCYTES WITH DIFFERENTIATION. EXPERIMENTAL HEMATOLOGY, 16(6), 536.
WoS11988 Sutherland, G. R., Baker, E., Callen, D. F., Hyland, V. J., Wong, G., Clark, S., . . . Vadas, M. A. (1988). Interleukin 4 is at 5q31 and interleukin 6 is at 7p15. Human Genetics, 79(4), 335-337.
Scopus92 WoS96 Europe PMC581988 Sutherland, G. R., Baker, E., Callen, D. F., Campbell, H. D., Young, I. G., Sanderson, C. J., . . . Vadas, M. A. (1988). Interleukin-5 is at 5q31 and is deleted in the 5q-syndrome. Blood, 71(4), 1150-1152.
Scopus85 WoS94 Europe PMC451987 LOPEZ, A. F., CLARKLEWIS, I., KENT, S. B. H., TO, L. B., WONG, G., HOOD, L. E., . . . VADAS, M. A. (1987). BIOLOGICAL PROPERTIES OF RECOMBINANT AND CHEMICALLY-SYNTHESIZED HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (CM-CSF). LYMPHOKINE RESEARCH, 6(1), U90. 1987 SHANNON, M. F., SIMMERS, R. N., SMITH, J., WONG, G., LOPEZ, A. F., BAKER, E., . . . VADAS, M. A. (1987). LOCALIZATION OF THE HUMAN G-CSF GENE TO THE REGION OF A BREAKPOINT IN THE TRANSLOCATION TYPICAL OF ACUTE PROMYELOCYTIC LEUKEMIA. LYMPHOKINE RESEARCH, 6(1), U91.
WoS11987 Vadas, M. A., Lopez, A. F., Shannon, M. F., & Atkinson, Y. (1987). Human myeloid growth factors. Immunology and Cell Biology, 65(2), 141-145.
Scopus4 WoS4 Europe PMC31987 Hart, P. H., Spencer, L. K., Kenny, P. A., Lopez, A. F., McDonald, P. J., & Finlay-Jones, J. J. (1987). Functional neutrophils from long-term murine bone marrow cell cultures. Journal of Immunological Methods, 100(1-2), 223-233.
Scopus6 WoS9 Europe PMC61987 Lopez, A. F., To, L. B., Yang, Y. C., Gamble, J. R., Shannon, M. F., Burns, G. F., . . . Vadas, M. A. (1987). Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2761-2765.
Scopus160 WoS223 Europe PMC421987 VADAS, M. A., ATKINSON, V. H., & LOPEZ, A. F. (1987). RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA(RHTNF-ALPHA) - REGULATION OF FMET-LEU-PHE RECEPTOR EXPRESSION AND FUNCTION ON HUMAN-NEUTROPHILS. IMMUNOBIOLOGY, 175(1-2), 122.
WoS11987 Puddington, L., Woodgett, C., & Rose, J. K. (1987). Replacement of the cytoplasmic domain alters sorting of a viral glycoprotein in polarized cells.. Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2756-2760.
Europe PMC601987 Burgess, A. W., Begley, C. G., Johnson, G. R., Lopez, A. F., Williamson, D. J., Mermod, J. J., . . . DeLamarter, J. F. (1987). Purification and properties of bacterially synthesized human granulocyte-macrophage colony stimulating factor. Blood, 69(1), 43-51.
Scopus204 WoS246 Europe PMC991987 TO, L. B., LOPEZ, A. F., YANG, Y. C., GAMBLE, J. R., DYSON, P. G., SHANNON, M. F., . . . VADAS, M. A. (1987). STIMULATION OF PROLIFERATION, DIFFERENTIATION AND FUNCTION OF HUMAN-CELLS BY PRIMATE INTERLEUKIN-3. EXPERIMENTAL HEMATOLOGY, 15(5), 563. 1986 Metcalf, D., Begley, C. G., Johnson, G. R., Nicola, N. A., Vadas, M. A., Lopez, A. F., . . . Wang, E. A. (1986). Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor. Blood, 67(1), 37-45.
Scopus349 WoS512 Europe PMC2051986 Metcalf, D., Begley, C. G., Johnson, G. R., Nicola, N. A., Lopez, A. F., & Williamson, D. J. (1986). Effects of purified bacterially synthesized murine Multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood, 68(1), 46-57.
Scopus225 WoS321 Europe PMC1421986 Nicola, N. A., Vadas, M. A., & Lopez, A. F. (1986). Down‐modulation of receptors for granulocyte colony‐stimulating factor on human neutrophils by granulocyte‐activating agents. Journal of Cellular Physiology, 128(3), 501-509.
Scopus63 WoS79 Europe PMC281986 Burns, G. F., Cosgrove, L., Triglia, T., Beall, J. A., López, A. F., Werkmeister, J. A., . . . Cawley, J. C. (1986). The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Cell, 45(2), 269-280.
Scopus47 WoS91 Europe PMC411986 Hart, P. H., Spencer, L. K., Nikoloutsopoulos, A., Lopez, A. F., Vadas, M. A., Mcdonald, P. J., & Finlay-Jones, J. J. (1986). Role of cell surface receptors in the regulation of intracellular killing of bacteria by murine peritoneal exudate neutrophils. Infection and Immunity, 52(1), 245-251.
Scopus18 WoS24 Europe PMC141986 Lopez, A. F., Begley, C. G., Williamson, D. J., Warren, D. J., Vadas, M. A., & Sanderson, C. J. (1986). Murine eosinophil differentiation factor: An eosinophil-specific colony-stimulating factor with activity for human cells. Journal of Experimental Medicine, 163(5), 1085-1099.
Scopus149 WoS162 Europe PMC901986 LOPEZ, A. F., WILLIAMSON, D. J., BEGLEY, C. G., NICOLA, N. A., WONG, G., CLARK, S. C., & VADAS, M. A. (1986). A RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (RH GM-CSF) STIMULATES INVITRO MATURE HUMAN NEUTROPHIL AND EOSINOPHIL FUNCTION, SURFACE-RECEPTOR EXPRESSION AND SURVIVAL. JOURNAL OF CELLULAR BIOCHEMISTRY, 93. 1986 Begley, C. G., Lopez, A. F., Nicola, N. A., Warren, D. J., Vadas, M. A., Sanderson, C. J., & Metcalf, D. (1986). Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: A rapid and sensitive microassay for colony-stimulating factors. Blood, 68(1), 162-166.
Scopus227 WoS270 Europe PMC1451986 LOPEZ, A. F., BEGLEY, C. G., WILLIAMSON, D. J., NICOLA, N. A., WARREN, D. J., SANDERSON, C. J., . . . VADAS, M. A. (1986). LINEAGE-SPECIFIC STIMULATION OF MATURE CELLS BY CSF. FEDERATION PROCEEDINGS, 45(3), 264. 1986 Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlan, J. M., Klebanoff, S. J., . . . Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. Journal of Clinical Investigation, 78(5), 1220-1228.
Scopus609 WoS779 Europe PMC3821986 BURNS, G. F., LOPEZ, A. F., BEALL, J. A., VADAS, M. A., & BEGLEY, C. G. (1986). A FUNCTIONAL-ROLE FOR THE IIB-IIIA GLYCOPROTEIN COMPLEX PRESENT ON LEUKOCYTES. FEDERATION PROCEEDINGS, 45(3), 635. 1985 Pentilla, I. A., Ey, P. L., Lopez, A. F., & Jenkin, C. R. (1985). Suppression of early immunity to Nematospiroides dubius in mice by selective depletion of neutrophils with monoclonal antibody. Australian Journal of Experimental Biology and Medical Science, 63(5), 531-543.
Scopus8 Europe PMC61985 PENTILLA, I. A., EY, P. L., LOPEZ, A. F., & JENKIN, C. R. (1985). SUPPRESSION OF EARLY IMMUNITY TO NEMATOSPIROIDES-DUBIUS IN MICE BY SELECTIVE DEPLETION OF NEUTROPHILS WITH MONOCLONAL-ANTIBODY. AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 63(OCT), 531-543.
WoS111985 Vadas, M. A., Lopez, A. F., & Williamson, D. J. (1985). Selective enhancement of the expression of granulocyte functional antigens 1 and 2 on human neutrophils. Proceedings of the National Academy of Sciences of the United States of America, 82(8), 2503-2507.
Scopus9 WoS20 Europe PMC71985 Begley, C. G., Metcalf, D., Lopez, A. F., & Nicola, N. A. (1985). Fractioned populations of normal human marrow cells respond to both human colony-stimulating factors with granulocyte-macrophage activity. Experimental Hematology, 13(9), 956-962.
Scopus13 WoS28 Europe PMC51985 Vadas, M. A., Clarke, C., Nicola, N. A., & Lopez, A. F. (1985). Correlation between the stimulation of human neutrophil function by monoclonal antibody and by colony-stimulating factor. Blood, 66(3), 738-741.
Scopus5 WoS13 Europe PMC31985 Lopez, A. F., Begley, G., Andrews, P., Butterworth, A. E., & Vadas, M. A. (1985). Identification of a human granulocyte functional antigen (GFA-2) involved in antibody-dependent cell-mediated cytotoxicity and phagocytosis. Journal of Immunology, 134(6), 3969-3977.
Scopus12 WoS26 Europe PMC101985 Begley, C. G., Lopez, A. F., Vadas, M. A., & Metcalf, D. (1985). The clonal proliferation in vitro of enriched populations of human promyelocytes and myelocytes. Blood, 65(4), 951-958.
Scopus11 WoS25 Europe PMC101985 Lopez, A. F., Battye, F. L., & Vadas, M. A. (1985). Fc receptors on mouse neutrophils and eosinophils: Antigenic characteristics, isotype specificity and relative cell membrane density measured by flow cytometry. Immunology, 55(1), 125-133.
Scopus12 WoS17 Europe PMC111984 Vadas, M. A., Nicola, N., Lopez, A. F., Metcalf, D., Johnson, G., & Pereira, A. (1984). Mononuclear cell-mediated enhancement of granulocyte function in man. Journal of Immunology, 133(1), 202-207.
Scopus37 WoS67 Europe PMC331984 Lopez, A. F., Triglia, T., Werkmeister, J. A., & Burns, G. F. (1984). A mature myeloid antigen identified on human natural killer cells. Australian Journal of Experimental Biology and Medical Science, 62(4), 445-451.
1984 Vadas, M., Lopez, A., & Begley, C. (1984). Stimulation of human granulocyte function by monoclonal antibody. Federation Proceedings, 43(6). 1984 Lopez, A. F., & Vadas, M. A. (1984). Stimulation of human granulocyte function by monoclonal antibody WEM-G1. Proceedings of the National Academy of Sciences of the United States of America, 81(6 I), 1818-1821.
Scopus14 WoS31 Europe PMC91984 López, A. F., Burns, G. F., & Stanley, I. J. (1984). Epitope diversity of monoclonal antibodies revealed by cross-species reactivity. Molecular Immunology, 21(5), 371-374.
Scopus6 WoS16 Europe PMC101984 Lopez, A. F., Strath, M., & Sanderson, C. J. (1984). Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies. British Journal of Haematology, 57(3), 489-494.
Scopus80 WoS93 Europe PMC681984 Vadas, M. A., & Lopez, A. F. (1984). Regulation of granulocyte function by colony stimulating factors. Lymphokine Research, 3(2), 45-50.
Scopus6 WoS10 Europe PMC51983 LÓPEZ, A. F., SANTOS, R. R. D., & SANDERSON, C. J. (1983). Antibody‐dependent cytotoxicity of Trypanosoma cruzi antigen‐coated mouse cell lines by eosinophils and neutrophils. Parasite Immunology, 5(1), 77-84.
Scopus1 WoS6 Europe PMC11983 Lopez, A. F., Strath, M., & Sanderson, C. J. (1983). Mouse immunoglobulin isotypes mediating cytotoxicity of target cells by eosinophils and neutrophils. Immunology, 48(3), 503-509.
Scopus20 WoS35 Europe PMC151983 Lopez, A. F., Nicola, N. A., Burgess, A. W., Metcalf, D., Battye, F. L., Sewell, W. A., & Vadas, M. (1983). Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors. Journal of Immunology, 131(6), 2983-2988.
Scopus145 WoS231 Europe PMC821982 Lopez, A. F., & Sanderson, C. J. (1982). Antibody-dependent, cell-mediated cytotoxicity of nucleated mammalian cells by rat eosinophils and neutrophils. International Archives of Allergy and Applied Immunology, 67(3), 200-205.
Scopus7 WoS9 Europe PMC41981 Lopez, A. F., Strath, M., & Sanderson, C. J. (1981). IgG and complement receptors on purified mouse eosinophils and neutrophils. Immunology, 43(4), 779-786.
Scopus19 WoS33 Europe PMC231978 Sanderson, C. J., Moreno, M. M. B., & Lopez, A. F. (1978). Antibody dependent cell-mediated cytotoxicity of Trypanosoma cruzi: The release of tritium-labelled RNA, DNA and protein. Parasitology, 76(3), 299-307.
Scopus17 WoS31 Europe PMC151978 López, A. F., Moreno, M. M. B., & Sanderson, C. J. (1978). The lysis of Trypanosoma cruzi epimastigotes by eosinophils and neutrophils. International Journal for Parasitology, 8(6), 485-489.
Scopus9 WoS18 Europe PMC101977 Sanderson, C. J., Lopez, A. F., & Moreno, M. M. B. (1977). Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes. Nature, 268(5618), 340-341.
Scopus30 WoS64 Europe PMC29 -
Books
Year Citation 2005 Thomas, D., Guthridge, M., Woodcock, J., & Lopez, A. (2005). Protein Signaling in Development and Growth Factor Responses (Vol. 67). G. P. Schatten (Ed.), ELSEVIER ACADEMIC PRESS INC.
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Book Chapters
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Conference Papers
Year Citation 2016 Yip, K. H., Kolesnikoff, N., Hauschild, N., Lopez, A. F., Galli, S. J., Kumar, S., & Grimbaldeston, M. A. (2016). The Nedd4-2-Ndfip1 axis is essential to curtail mast cell-dependent IgE-mediated anaphylaxis <i>in vivo</i>. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 16-17). Melbourne, AUSTRALIA: WILEY-BLACKWELL. 2014 Broughton, S. E., Hercus, T. R., Nero, T. L., Dhagat, U., Dottore, M., McClure, B. J., . . . Parker, M. W. (2014). Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex. In CYTOKINE Vol. 70 (pp. 32). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
2014 Hercus, T. R., Broughton, S. E., Hardy, M. P., Nero, T. L., McClure, B. J., Dottore, M., . . . Lopez, A. F. (2014). Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123. In CYTOKINE Vol. 70 (pp. 46). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
2011 Nievergall, E., White, D. L., Ramshaw, H., Lopez, A. F., Hughes, T. P., & Hiwase, D. K. (2011). Antibody-Targeting of IL-3 Receptor-α Increases the Susceptibility of CD34<SUP>+</SUP> CML Progenitors to Dasatinib-Induced Cell Death. In BLOOD Vol. 118 (pp. 1599). San Diego, CA: AMER SOC HEMATOLOGY.
WoS12010 Sadras, T., Perugini, M., Ramshaw, H. S., Salerno, D. G., Lewis, I. D., Lopez, A. F., . . . D'Andrea, R. J. (2010). IL-3 MEDIATED ACTIVATION OF β-CATENIN IN ACUTE MYELOID LEUKEMIA. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S59). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2010 Thomas, D., Powell, J. A., Barry, E. F., Woodcock, J., Ekert, P. G., Green, B. D., . . . Guthridge, M. A. (2010). THE PROTEIN KINASE ACTIVITY OF PHOSPHOINOSITIDE 3-KINASE ALPHA PROMOTES AUTONOMOUS CELL SURVIVAL IN AML STEM/PROGENITOR CELLS. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S87). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2010 Powell, J. A., Thomas, D., Barry, E. F., Kok, C. H., Ma, L. Y., To, L. B., . . . Guthridge, M. A. (2010). TARGETING CELL SURVIVAL PATHWAYS IN ACUTE MYELOID LEUKEMIA. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S60). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2008 Thomas, D., Woodcock, J., Powell, J. A., Barry, E. F., Lopez, A. F., & Guthridge, M. A. (2008). Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia. In BLOOD Vol. 112 (pp. 1315). San Francisco, CA: AMER SOC HEMATOLOGY.
WoS32005 Thomas, D., Powell, J., Lee, S. H., Lopez, A. F., & Mark, G. (2005). Primary acute myeloid leukemic blasts display constitutive serine 585 phosphorylation within the 14-3-3 binding motif of the GM-CSF/IL-3 receptor required for survival signalling.. In BLOOD Vol. 106 (pp. 25A). Atlanta, GA: AMER SOC HEMATOLOGY. 2005 Powell, J. A., Thomas, D., Lee, S. H., Lopez, A. F., & Guthridge, M. A. (2005). Constitutive serine-585 phosphorylation of the GM-CSF receptor and the deregulation of survival signalling in AML blasts. In EXPERIMENTAL HEMATOLOGY Vol. 33 (pp. 74). Univ Glasgow, Glasgow, SCOTLAND: ELSEVIER SCIENCE INC. 1997 Crowe, S. M., & Lopez, A. (1997). GM-CSF and its effects on replication of HIV-1 in cells of macrophage lineage. In Journal of Leukocyte Biology Vol. 62 (pp. 41-48). VERONA, ITALY: FEDERATION AMER SOC EXP BIOL.
Scopus26 WoS24 Europe PMC141997 Woodcock, J., McClure, B., Stomski, F., Bagley, C., & Lopez, A. (1997). The mechanism of GM-CSF receptor activation. In EXPERIMENTAL HEMATOLOGY Vol. 25 (pp. 111). CARDEN JENNINGS PUBL CO LTD. 1992 Macpherson, J. L., Lopez, A., & Krilis, S. A. (1992). Co-culture of human bone marrow cells with a mastocytosis cell strain induces mast cell/basophil differentiation. In International Archives of Allergy and Immunology Vol. 99 (pp. 346-349). CAPRI, ITALY: KARGER.
Scopus3 WoS2 -
Conference Items
Year Citation 2019 El Khawanky, N., Hughes, A., Yu, W., Taromi, S., Clarson, J., Lopez, A. F., . . . Zeiser, R. (2019). Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
WoS42017 El-Khawanky, N., Hughes, A., Yu, W., Clarson, J., Lopez, A. F., Brown, M., . . . Yong, A. (2017). CD123 Chimeric Antigen Receptor T-cells in Chronic and Acute Myeloid Leukaemia: pre-clinical in vitro studies. Poster session presented at the meeting of HAA. 2013 Van Der Wal, A., Cranmer, S., Ramshaw, H., Van der Wal, E., Schoenwaelder, M., Yuan, Y., . . . Jackson, S. (2013). 14-3-3? regulates the procoagulant function of platelets. Poster session presented at the meeting of Abstracts of the 24th Congress of the International Society on Thrombosis and Haemostasis, as published in Journal of Thrombosis and Haemostasis. Amsterdam, The Netherlands: Wiley-Blackwell.
2012 Nievergall, E., White, D. L., Yong, A. S. M., Ramshaw, H. S., Busfield, S. J., Vairo, G., . . . Hiwase, D. K. (2012). Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
2012 Lim, G. E., Piske, M., Ramshaw, H. S., Guthridge, M. A., Lopez, A. F., & Johnson, J. D. (2012). 14-3-3 proteins are required for pancreatic beta cell survival and glucose homeostasis. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER. 2012 Markey, K. A., Koyama, M., Kuns, R. D., Lineburg, K. E., Wilson, Y. A., Olver, S. D., . . . MacDonald, K. P. A. (2012). Immune insufficiency after experimental transplantation is due to defective antigen presentation within dendritic cell subsets. Poster session presented at the meeting of Abstracts from the 2012 BMT Tandem Meetings, as published in Biology of Blood And Marrow Transplantation. San Diego, CA: Elsevier Science.
2012 Busfield, S. J., Biondo, M., Wong, M., Ramshaw, H. S., Lee, E. M., Martin, K., . . . Nash, A. (2012). CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
WoS12012 Lim, G. E., Piske, M., Ramshaw, H. S., Guthridge, M. A., Lopez, A. F., & Johnson, J. D. (2012). 14-3-3ζ is required for glucose homeostasis, lipid metabolism, and adipogenesis.. Poster session presented at the meeting of MOLECULAR BIOLOGY OF THE CELL. AMER SOC CELL BIOLOGY. 2011 Sadras, T., Perugini, M., Ramshaw, H. S., Salerno, D. G., Kok, C. H., Lewis, I. D., . . . D'Andrea, R. J. (2011). IL-3 REGULATES B-CATENIN IN MYELOID CELLS AND ENFORCED EXPRESSION OF B-CATENIN REDUCES THE DEPENDENCY ON IL-3 FOR SURVIVAL. Poster session presented at the meeting of EXPERIMENTAL HEMATOLOGY. ELSEVIER SCIENCE INC. 2000 Olver, I., Vadas, M., Lopez, A., Keefe, D., Taylor, A., Brown, M., & To, L. (2000). A phase 1 study of the GM-CSF antagonist E21R. Poster session presented at the meeting of Proceedings of ASCO - Volume 19 2000. USA: American Society of Clinical Oncology.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Immunological determinants of head and neck cancer progression and metastasis, in particular the role of cancer associated fibroblasts Master of Philosophy (Surgery) Master Full Time Miss Laura Kenyon 2020 Principal Supervisor Transforming growth factor beta as a differential regulator of Beta common receptor and Interleukin 3 receptor alpha expression. Doctor of Philosophy Doctorate Full Time Mrs Sepideh Azizi Taramsary -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2007 - 2012 Principal Supervisor Regulation of Cell Survival in Acute Myeloid Leukemia Doctor of Philosophy Doctorate Full Time Dr Daniel Thomas 2006 - 2011 Principal Supervisor Regulation of the BH3-only protein PUMA by growth factor signalling Doctor of Philosophy Doctorate Full Time Mr Jarrod Sandow 2002 - 2006 Principal Supervisor The Role of 14-3-3X in Cytokine Receptor Signalling Doctor of Philosophy Doctorate Full Time Mr Fernando Felquer 1998 - 2008 Principal Supervisor The Role of ?c Subunit Phosphorylation in the Functioning of the GM-CSF/IL-3/ IL-5 Receptors Doctor of Philosophy Doctorate Full Time Ms Wendy Winnall 1996 - 2017 Principal Supervisor Molecular Assembly of the Activated Granulocyte-Macrophage Colony-Stimulating Factor Receptor Doctor of Philosophy Doctorate Part Time Mrs Barbara Jean McClure
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