Daniel Thomas

Associate Professor Daniel Thomas

Associate Professor, Haematology

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


With unique training experience at the Stanford School of Medicine, including mentoring from Professors Ravindra Majeti, Irving Weissman, Hiro Nakauchi and Craig Jordan (UC Denver), Daniel Thomas is a clinical haematologist and pathologist whose goals in research are to develop new drugs for the treatment of cancer and lead a productive cutting-edge cancer research group in Australia.

The Thomas Lab on level 5 of SAHMRI (Precision Medicine, Cancer Theme) is focused on interplay between cancer, metabolism and epigenetics using myeloid cells as a human in vivo platform to discover new targets for common mutations that cause cancer. Dr Daniel Thomas is a clinical haematologist and pathologist whose goals in research are to develop new drugs for the treatment of cancer. He has had unique training experience at the Stanford School of Medicine with mentors who have discovered human stem cell populations in blood and bone marrow including Professor Ravindra Majeti, Irving Weissman and Hiro Nakauchi. If you are passionate about thinking outside the square to improve the treatment of cancer, please contact Dr Thomas about potential student internships.

The Thomas Lab has a strong track record in finding new druggable targets in cancer and predicting mutations that respond to specific targeted therapies as well as repurposing old drugs for new uses in cancer. Some of the discoveries that Dr Thomas has contributed to are already in the clinic or are under clinical investigation. These  include (i) discovery mutation-specific drug targets for acute myeloid leukaemia (EZH2 for AML with WT1 mutation, Blood 2015; Bcl2 for AML with IDH1 mutation, Nature Med 2016; ROS activation for AML with NPM1 mutation, Leukemia 2014; ACC1 for AML with IDH1 mutation, Nature Com, 2017), (ii) prediction of 145,891 synthetic partners for 3,120 recurrent mutations for 12 cancer types (Leukemia 2019, first author and co-inventor Nature Com, 2017, (iii) pre-clinical development of a biological therapy (humanized monoclonal antibody directed against CD123 Cell Stem Cell, 2009, Leukemia 2014) and (iv) comprehensive translational experience in the development of  a novel class of small molecular inhibitor for cancer in the Stanford Alliance for Innovative Medicines program.

Dr Thomas has been awarded a number of prizes for his work including the CSL Centenary Fellowship ($1.25M), K99-R00 Pathway to Independence award by the National Cancer Institute, NHMRC PhD award, Albert Bakie Medal, Douglas Hardy Prize, Nimmo Prize and CJ Martin Biomedical Fellowship.

The over-arching goal of Dan’s research is to find novel mutation-specific drug targets for somatic mutations, especially in poor prognosis and difficult to treat cancer types, using leukemia as a test bed. The lab has unique skills in developing humanized in vivo models for AML, isolation and testing of pre-leukemia stem cells and bioinformatic algorithms together with key academic and industry networks.

    Expand
  • Appointments

    Date Position Institution name
    2019 Titleholder Stanford University School of Medicine
    2019 Associate Professor South Australian Health and Medical Research Institute
    2017 - 2019 Instructor/Junior Faculty Stanford University School of Medicine
    2010 - 2012 Staff Specialist Royal Adelaide Hospital
    2000 - 2000 Resident Royal Adelaide Hospital
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2018 Award Stanford Alliance of Innovative Medicines Award Stanford University United States
    2015 Award Honorary Award for Outstanding Presentation, Stanford Hematology-Oncology Retreat Stanford University School of Medicine United States
    2015 Award Outstanding External Grant Reviewer for 2014 National Health and Medical Research Council of Australia Australia
    2014 Award Best Publication for Previous Year Centre for Cancer Biology Australia
    2014 Award Leukemia Foundation New Investigator Award Leukemia Foundation Australia
    2014 Award Outstanding Young Investigator Award, New Directions in Leukemia Research Conference New Directions in Leukemia Research Australia
    2012 Distinction Dean’s Commendation for Doctoral Thesis Excellence for PhD The University of Adelaide Australia
    2011 Fellowship HOTT Haematology/Oncology Targetted Therapy Fellowship Haematology Society of Australia & New Zealand/COSA/Roche/COGA Australia
    2010 Award Nimmo Prize, Best Full-Time Research Royal Adelaide Hospital Australia
    2010 Award Outstanding Research Presentation Prize, New Directions in Leukaemia Conference New Directions in Leukaemia Research (NDLR) Australia
    2010 Fellowship HSANZ Haematology Targeted Therapy Fellowship The Haematology Society of Australia and New Zealand Australia
    2008 Award National Adult Medicine Research Award Royal Australasian College of Physicians Australia
    2007 Award Albert Baikie Memorial Medal Haematology Society of Australia & New Zealand Australia
    2007 Award John Chalmers Prize for Best Medical Research Presentation Royal Australasian College of Physicians Australia
    2007 Scholarship The NHMRC Postgraduate Scholarship National Health & Medical Research Council Australia
    2004 Award Hugh Gilmore Prize for Best Presentation of Medical Research by a Physician in Training Royal Adelaide Hospital Australia
  • Education

    Date Institution name Country Title
    2012 University of Adelaide Australia PhD
    2000 University of Adelaide Australia Bachelor of Medicine and Bachelor of Surgery
    1998 University of Adelaide Australia Bachelor of Medical Science (Honours)
  • Postgraduate Training

    Date Title Institution Country
    2012 - 2013 Postdoctoral Fellow Stanford University School of Medicine United States
  • Certifications

    Date Title Institution name Country
    2007 Fellow (FRACP) Royal Australasian College of Physicians Australia
    2007 Fellow (FRCPA) Royal College of Pathologists of Australasia Australia
  • Research Interests

Date Project/No. Investigators Funding Body Amount
Jan 2017-Jan 2022 Discovery of Synthetic Lethal Targets for Recurrent Epigenetic Mutations in Acute Myeloid Leukemia/APP ID 88686 (Thomas) Thomas, D. National Cancer Institute USD$1,040,000
Jul 2018-Jul 2019

Potent and Selective ACC1 inhibitor for Cancer with IDH1 Mutations

Majeti, R. Stanford University USD$75,000
Jul 2014-Jan 2015 Data-Mining for Synthetic Lethal Targets in Acute Myeloid Leukemia

Majeti, R.    Dill, D.L.

National Institutes of Health USD$

Jan 2014-Jan 2015

SA PATH Equipment Grant/GNT9000253 Lopez, A. Hughes, T. Revesz, T. National Health and Medical Research Council AUD$9,634
Jan 2012-Dec 2017 Targetting Quiescence Signalling Pathways in AML Stem Cells/APP1037514 Thomas, D. National Health and Medical Research Council  
  • Position: Associate Professor, Haematology
  • Phone: 83131288
  • Email: daniel.thomas@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 6
  • Org Unit: Adelaide Medical School

Connect With Me
External Profiles