Barbara McClure
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Barbara McClure joined the Leukaemia Research group bringing with her expertise in the structure and function of cytokine receptors, proteins that tightly regulate normal haematopoiesis and whose alterations can result in haematological malignancies. Her position within the Genomics Research Team will be focused on investigating a cancer of white blood cells, Acute Lymphoblastic Leukaemia (ALL), an aggressive disease that is caused by a variety of genetic lesions. This research will focus on a new subtype of ALL, Ph-like ALL, which has an extremely poor prognosis. Using whole genome sequencing it has been identified that novel genetic fusions are present in the ALL patient samples. Dr McClure will be cloning these novel fusion genes and determining if the products of these fusion genes are the driving force responsible the uncontrolled leukaemic cell growth. Cell systems will then be developed to investigate the altered molecular events responsible for driving proliferation, and to determine if current therapeutics can abrogate the novel driver genes function. This work will help with improvement in the early diagnostic identification of ALL subtypes and to identify better therapeutic options for this aggressive disease.
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Appointments
Date Position Institution name 2017 Affiliate Lecturer University of Adelaide -
Education
Date Institution name Country Title 2017 University of Adelaide Australia PhD 1993 Univeristy of Adelaide Australia BSc(Hons) 1992 University of Adelaide Australia BSc -
Postgraduate Training
Date Title Institution Country — HDR Supervisor course University of Adelaide Australia -
Certifications
Date Title Institution name Country 2016 Class B & C Radiation Licence Environment Protection Office — -
Research Interests
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Journals
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Conference Papers
Year Citation 2017 Broughton, S. E., Hercus, T., Nero, T., Dottore, M., McClure, B., Dhagat, U., . . . Parker, M. W. (2017). The GM-CSF Receptor - mechanisms for affinity conversion and signalling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C1279). INT UNION CRYSTALLOGRAPHY.
2014 Broughton, S. E., Hercus, T., Nero, T., Dottore, M., McClure, B., Dhagat, U., . . . Parker, M. W. (2014). The GM-CSF Receptor - mechanisms for affinity conversion and signalling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C1279). INT UNION CRYSTALLOGRAPHY. 2014 Broughton, S. E., Hercus, T. R., Nero, T. L., Dhagat, U., Dottore, M., McClure, B. J., . . . Parker, M. W. (2014). Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex. In CYTOKINE Vol. 70 (pp. 32). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
2014 Hercus, T. R., Broughton, S. E., Hardy, M. P., Nero, T. L., McClure, B. J., Dottore, M., . . . Lopez, A. F. (2014). Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123. In CYTOKINE Vol. 70 (pp. 46). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
2009 Guthridge, M., Thomas, D., Barry, E. F., Chung, K. H., McClure, B. J., To, L. B., . . . Powell, J. A. (2009). Expression Profiling of a Hemopoietic Cell Survival Transcriptome Identifies a Functional Prognostic Gene Signature in Normal Karyotype AML.. In BLOOD Vol. 114 (pp. 647). New Orleans, LA: AMER SOC HEMATOLOGY. 2007 Lopez, A., Hercus, T., Hansen, G., Woodcock, J., McClure, B., Stomski, F., . . . Parker, M. P. (2007). The structure of the GM-CSF receptor ternary complex reveals a new, mode of cytokine receptor activation. In BLOOD Vol. 110 (pp. 35A). Atlanta, GA: AMER SOC HEMATOLOGY.
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Conference Items
Year Citation 2018 Downes, C., McClure, B., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland. 2018 Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . . . White, D. L. (2018). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of 23rd Congress of European Hematology Association. Stockholm, Sweden. 2018 Downes, C. E., McClure, B. J., Heatley, S. L., Yeung, D. T., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of NDLR. 2018 Heatley, S. L., McClure, B. J., Kok, C., Sadras, T., Dang, P., Galbraith, K., . . . White, D. L. (2018). Exploring the genomic diversity of adult and AYA cases with high-risk B-ALL by mRNA sequencing. Poster session presented at the meeting of NDLR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of APG Student Awards. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk JAK2 fusion in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and Characterisation of Ruxolitinib Resistant Mutations in JAK2-rearranged B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of AGTA. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of mutations that cause ruxolitinib resistance in Pro-B cells driven by a high-risk B-ALL JAK2-fusion.. Poster session presented at the meeting of ANZCHOG. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of SAHMRI Scientific Seminar. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium. 2017 McClure, B. J., Heatley, S. L., Kok, C., Sadras, T., An, J., Quek, K., . . . White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult pre-B-ALL patients. Poster session presented at the meeting of ANZCHOG. 2017 Heatley, S. L., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. L. (2017). High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk-Adapted Treatment. Poster session presented at the meeting of ANZCHOG. 2017 McClure, B. J., Heatley, S. L., Sadras, T., Sutton, R., & White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult Australian pre-B-acute lymphoblastic leukaemia. Poster session presented at the meeting of IBFM. 2017 Downes, C. E., McClure, B. M., Heatley, S. H., Sadras, T. S., Hughes, T. H., Kok, C. K., . . . White, D. W. (2017). Identification and cloning of a novel GOLGA4-JAK2 fusion from an adult patient with B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster session presented at the ASMR SA Scientific Meeting. Adelaide. 2016 White, D. L., McClure, B., Heatley, S., Sadras, T., Quek, K., & Hughes, T. (2016). Investigation of the transforming capacity of a recently identified EP300-ZNF384 fusion gene in adult acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Galbraith, K., Sadras, T., McClure, B., Heatley, S., & White, D. L. (2016). Identification of novel therapeutic targets in CRLF2 rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Heatley, S., Sadras, T., McClure, B., Kok, C. H., Dang, P., Nievergall, E., . . . White, D. L. (2016). The Incidence of Ph-like Acute Lymphoblastic Leukaemia (ALL) Increases with Age and is Characterised by Poor Outcome. Poster session presented at the meeting of Poster Session. Melbourne, VIC. -
Theses
Year Citation 2017 Downes, C. E. (2017). Cloning, Signalling Characterisation and JAK2 Inhibitor-Resistance of Two JAK2 Fusions in High-Risk B-ALL. (Undergraduate Dissertation).
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor Characterising KMT2A and MLLT10 rearranged acute lymphoblastic leukaemia Doctor of Philosophy Doctorate Full Time Miss Michelle Olivia Forgione 2019 Co-Supervisor Characterisation of the impact of cytokine profiles, the microbiome and innate immunity on the response of Acute Lymphoblastic Leukaemia (ALL) patients to contemporary therapies Doctor of Philosophy Doctorate Full Time Miss Stephanie Jade Field 2018 Co-Supervisor Characterising signalling cascades and investigating therapeutic targets in JAK2-rearranged acute lymphoblastic leukaemia Doctor of Philosophy Doctorate Full Time Miss Charlotte Emma-Jeane Downes
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Committee Memberships
Date Role Committee Institution Country 2017 - ongoing Member SAHMRI Radiation Safety Committee SAHMRI Australia -
Memberships
Date Role Membership Country 2016 - ongoing Member Australian Society of Medical Research Australia 2016 - ongoing Member Australian Epigenetics Alliance Australia
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