Mrs Barbara McClure
Research Associate
Centre for Cancer Biology
College of Health
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Barbara McClure is a mid-career researcher currently appointed as a Research Associate in the Vascular Biology and Cell Trafficking Laboratory at The Centre for Cancer Biology, Adelaide Univeristy. She had significant experience studying haematological malignancies including genomics, molecular, receptor and cellular biology. With published 58 peer reviewed articles receiving >1800 citations she was named named an AMP Tomorrow Maker in 2019. Her current research focus is understanding how a biomarker for poor prognosis Multiple Myeloma contributes to disease progression.
I am a mid-career researcher currently appointed as a Research Associate at The Centre for Cancer Biology in the Vascular Biology and Cell Trafficking Laboratory. I have significant experience studying haematological malignancies including genomics, molecular, receptor and cellular biology. I have published 58 peer reviewed articles receiving >1700 citations. My current research focus is understanding how a biomarker for poor prognosis Multiple Myeloma contributes to disease progression.
| Date | Position | Institution name |
|---|---|---|
| 2017 - ongoing | Affiliate Lecturer | University of Adelaide |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2017 | University of Adelaide | Australia | PhD |
| 1993 | Univeristy of Adelaide | Australia | BSc(Hons) |
| 1992 | University of Adelaide | Australia | BSc |
| Date | Title | Institution | Country |
|---|---|---|---|
| HDR Supervisor course | University of Adelaide | Australia |
| Date | Title | Institution name | Country |
|---|---|---|---|
| 2016 | Class B & C Radiation Licence | Environment Protection Office | - |
| Year | Citation |
|---|---|
| 2017 | Broughton, S. E., Hercus, T., Nero, T., Dottore, M., McClure, B., Dhagat, U., . . . Parker, M. W. (2017). The GM-CSF Receptor - mechanisms for affinity conversion and signalling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C1279). INT UNION CRYSTALLOGRAPHY. DOI |
| 2014 | Broughton, S. E., Hercus, T., Nero, T., Dottore, M., McClure, B., Dhagat, U., . . . Parker, M. W. (2014). The GM-CSF Receptor - mechanisms for affinity conversion and signalling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C1279). INT UNION CRYSTALLOGRAPHY. |
| 2014 | Broughton, S. E., Hercus, T. R., Nero, T. L., Dhagat, U., Dottore, M., McClure, B. J., . . . Parker, M. W. (2014). Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex. In CYTOKINE Vol. 70 (pp. 32). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. DOI |
| 2014 | Hercus, T. R., Broughton, S. E., Hardy, M. P., Nero, T. L., McClure, B. J., Dottore, M., . . . Lopez, A. F. (2014). Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123. In CYTOKINE Vol. 70 (pp. 46). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. DOI WoS1 |
| 2009 | Guthridge, M., Thomas, D., Barry, E. F., Chung, K. H., McClure, B. J., To, L. B., . . . Powell, J. A. (2009). Expression Profiling of a Hemopoietic Cell Survival Transcriptome Identifies a Functional Prognostic Gene Signature in Normal Karyotype AML.. In BLOOD Vol. 114 (pp. 647). New Orleans, LA: AMER SOC HEMATOLOGY. |
| 2007 | Lopez, A., Hercus, T., Hansen, G., Woodcock, J., McClure, B., Stomski, F., . . . Parker, M. P. (2007). The structure of the GM-CSF receptor ternary complex reveals a new, mode of cytokine receptor activation. In BLOOD Vol. 110 (pp. 35A). Atlanta, GA: AMER SOC HEMATOLOGY. DOI |
| Year | Citation |
|---|---|
| 2024 | Toomes, C., McClure, B., Best, G., Ebert, L., Vandyke, K., Cockshell, M., . . . Bonder, C. (2024). Elevated Desmoglein-2 Surface Expression Is an Independent Predictor of Poor Outcome in Multiple Myeloma. Poster session presented at the meeting of CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. |
| 2024 | Toomes, C., McClure, B., Best, G., Ebert, L., Vandyke, K., Cockshell, M., . . . Bonder, C. (2024). Elevated desmoglein-2 surface expression is a predictor of poor outcome in multiple myeloma. Poster session presented at the meeting of Poster, SA Cancer Clinical Research Symposium. |
| 2024 | Toomes, C., McClure, B., Best, G., Ebert, L., Vandyke, K., Cockshell, M., . . . Bonder, C. (2024). Elevated desmoglein-2 surface expression is an independent predictor of poor outcome in multiple myeloma. Poster session presented at the meeting of Oral, Australian Society for Medical Research (ASMR) National Scientific Conference. |
| 2023 | Toomes, C., Best, G., McClure, B., Bonder, C., & Wallington-Gates, C. (2023). Understanding Desmoglein-2 (DSG2) and its association with poor outcomes in multiple myeloma. Poster session presented at the meeting of Oral, Flinders University Emerging Leaders Showcase. |
| 2023 | Rehn, J., Schutz, C., Page, E., Heatley, S., Eadie, L., McClure, B., . . . White, D. (2023). High expression of DUX4 mRNA is a reliable indicator of DUX4-rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian and New Zealand Children’s Haematology/Oncology group (ANZCHOG) Scientific Meeting. |
| 2022 | Toomes, C., McClure, B., Bruning, J., Page, E., Breen, J., Rehn, J., . . . White, D. (2022). Acquired JAK2 kinase domain mutations confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, New Directions in Leukaemia Research (NDLR). |
| 2022 | Thomson, A., Rehn, J., Heatley, S., Eadie, L., McClure, B., Page, E., . . . White, D. (2022). Benchmarking the detection rate of IGH gene fusions in B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) Conference. |
| 2021 | Heatley, S. L., Page, E. C., Eadie, L. N., McClure, B. J., Rehn, J., Yeung, D. T., . . . White, D. L. (2021). Modeling Relapsed, Refractory Acute Lymphoblastic Leukemia from a Child with Neurofibromatosis. Poster session presented at the meeting of BLOOD. GA, Atlanta: AMER SOC HEMATOLOGY. DOI WoS1 |
| 2021 | Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 4th International T-ALL/T-NHL conference: T-ALL2020: Omics, genetics and therapy. |
| 2021 | McClure, B., Heatley, S., Grose, R., & White, D. (2021). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). |
| 2021 | Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). |
| 2021 | Toomes, C., McClure, B., Bruning, J., Breen, J., Rehn, J., Yeung, D., & White, D. (2021). Acquired JAK2 kinase domain mutations confer resistance to JAK inhibitors in cell models of a high-risk acute lymphoblastic leukaemia. Poster session presented at the meeting of Oral, South Australian Health and Medical Research Institute (SAHMRI) Research Showcase. |
| 2021 | Toomes, C., McClure, B., Bruning, J., Breen, J., Rehn, J., Hughes, T., . . . White, D. (2021). Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, Lorne Cancer Conference. |
| 2021 | Toomes, C., McClure, B., Bruning, J., Breen, J., Rehn, J., Hughes, T., . . . Yeung, D. (2021). Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of high-risk ALL. Poster session presented at the meeting of Poster, European School of Haematology (ESH) Translational Research Conference. |
| 2021 | Toomes, C., McClure, B., Bruning, J., Breen, J., Rehn, J., Yeung, D., & White, D. (2021). Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) Annual Scientific Meeting. |
| 2021 | Toomes, C., McClure, B., Bruning, J., Breen, J., Rehn, J., Yeung, D., & White, D. (2021). Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of acute lymphoblastic leukaemia. Poster session presented at the meeting of Oral, Haematology Society of Australia & New Zealand (HSANZ) Blood Meeting. |
| 2020 | Toomes, C., McClure, B., Bruning, J., & White, D. (2020). The race is on in high-risk acute lymphoblastic leukaemia. Poster session presented at the meeting of Oral, University of Adelaide School of Biological Sciences Postgraduate Symposium. |
| 2020 | Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Targeted pseudo-alignment technique for rapid and accurate identification of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of 14th Annual Florey Postgraduate Conference. Adelaide, South Australia. |
| 2020 | Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Pseudo-alignment technique for accurate detection of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) 2020 National Conference. Canberra, ACT. |
| 2020 | Forgione, M. O., McClure, B. J., Eadie, L. N., & White, D. L. (2020). CD44 and its ligand osteopontin are upregulated specifically in KMT2A-AFF1 T-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. |
| 2020 | Eadie, L. N., Rehn, J., Heatley, S. L., McClure, B. J., Schutz, C. S., Breen, J., . . . White, D. L. (2020). Next Generation Genomic Analyses in T-ALL Patients Identify Recurrent and Novel Genomic Abnormalities. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: ELSEVIER. DOI WoS1 |
| 2020 | Eadie, L., Heatley, S., McClure, B., Schutz, C., Breen, J., Hughes, T., . . . White, D. (2020). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. |
| 2020 | McClure, B., Heatley, S., Grose, R., Yeung, D., & White, D. (2020). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia.. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. |
| 2020 | Downes, C. E. J., McClure, B. J., Rehn, J., Breen, J., Bruning, J. B., Yeung, D. T., & White, D. L. (2020). Acquired Mutations within the JAK2 Kinase Domain Confer Resistance to JAK Inhibitors in an <i>in Vitro</i> model of a High-Risk Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: ELSEVIER. DOI WoS2 |
| 2019 | Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of 1st European Society of Haematology (ESH) Translational Conference on ALL. Berlin, Germany. |
| 2019 | Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. |
| 2019 | Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L., Schutz, C. E., . . . White, D. L. (2019). Investigating “alignment-free” computational techniques for the accurate identification of Acute Lymphoblastic Leukaemia (ALL) gene fusion events. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. |
| 2019 | Heatley, S. L., McClure, B. J., Eadie, L. N., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. |
| 2019 | Yeung, D., Greenwood, M., Rehn, J., Heatley, S., McClure, B., Eadie, L., . . . White, D. (2019). High risk genomic alterations identified at the time of diagnosis are strongly associated with MRD and subsequent poor outcomes in AYA ALL patients treated on a pediatric inspired chemotherapy regimen. Poster session presented at the meeting of Blood. Orlando, CA: American Society of Hematology. DOI |
| 2019 | Toomes, C., McClure, B., Mayne, B., Bruning, J., Heatley, S., Kok, C., . . . White, D. (2019). Identification and characterisation of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, Australian Society for Medical Research (ASMR) SA Meeting. |
| 2019 | Toomes, C., McClure, B., Bruning, J., & White, D. (2019). JAK2 kinase domain mutations confer resistance to JAK inhibitors in a pro-B cell model of high-risk acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, University of Adelaide School of Biological Sciences Postgraduate Symposium. |
| 2018 | Downes, C., McClure, B., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Poster, Childhood Leukemia and Lymphoma Symposium (CLLS). Helsinki, Finland. |
| 2018 | Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . . . White, D. L. (2018). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of 23rd Congress of European Hematology Association. Stockholm, Sweden. |
| 2018 | Downes, C. E., McClure, B. J., Heatley, S. L., Yeung, D. T., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Poster, New Directions in Leukaemia Research (NDLR). |
| 2018 | Heatley, S. L., McClure, B. J., Kok, C., Sadras, T., Dang, P., Galbraith, K., . . . White, D. L. (2018). Exploring the genomic diversity of adult and AYA cases with high-risk B-ALL by mRNA sequencing. Poster session presented at the meeting of NDLR. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, Adelaide Protein Group (APG) Student Awards. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk JAK2 fusion in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Oral, Australian Society for Medical Research (ASMR) SA Meeting. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and Characterisation of Ruxolitinib Resistant Mutations in JAK2-rearranged B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster, Australasian Genomic Technologies Association (AGTA) Annual Conference. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Poster, Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) Annual Scientific Meeting. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, South Australian Health and Medical Research Institute (SAHMRI) Annual Scientific Meeting. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, European Molecular Biology Laboratory (EMBL) Australia Postgraduate Symposium. |
| 2017 | McClure, B. J., Heatley, S. L., Kok, C., Sadras, T., An, J., Quek, K., . . . White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult pre-B-ALL patients. Poster session presented at the meeting of ANZCHOG. |
| 2017 | Heatley, S. L., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. L. (2017). High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk-Adapted Treatment. Poster session presented at the meeting of ANZCHOG. |
| 2017 | McClure, B. J., Heatley, S. L., Sadras, T., Sutton, R., & White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult Australian pre-B-acute lymphoblastic leukaemia. Poster session presented at the meeting of IBFM. |
| 2017 | Downes, C. E., McClure, B. M., Heatley, S. H., Sadras, T. S., Hughes, T. H., Kok, C. K., . . . White, D. W. (2017). Identification and cloning of a novel GOLGA4-JAK2 fusion from an adult patient with B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster, Australian Society for Medical Research (ASMR) SA Meeting. Adelaide. |
| 2016 | White, D. L., McClure, B., Heatley, S., Sadras, T., Quek, K., & Hughes, T. (2016). Investigation of the transforming capacity of a recently identified EP300-ZNF384 fusion gene in adult acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. |
| 2016 | Galbraith, K., Sadras, T., McClure, B., Heatley, S., & White, D. L. (2016). Identification of novel therapeutic targets in CRLF2 rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. |
| 2016 | Heatley, S., Sadras, T., McClure, B., Kok, C. H., Dang, P., Nievergall, E., . . . White, D. L. (2016). The Incidence of Ph-like Acute Lymphoblastic Leukaemia (ALL) Increases with Age and is Characterised by Poor Outcome. Poster session presented at the meeting of Poster Session. Melbourne, VIC. |
| Year | Citation |
|---|---|
| 2017 | Downes, C. E. (2017). Cloning, Signalling Characterisation and JAK2 Inhibitor-Resistance of Two JAK2 Fusions in High-Risk B-ALL. (Undergraduate Dissertation). |
Grants:
2025 Therapeutic Innovation Australia Pipeline Accelerator (AI) $50,000
2025 CHS Grant-in-Aid (CI) $10,000
Grant – Targeting a cancer specific biomarker for improved therapeutics to combat Multiple Myeloma
2023 CUREator Preclinical Stream (AI) $650,000
Grant – DesmoX, advancing anti-cancer agents.
2019 AMP Tomorrow Fund Grant (CI) $22,500
Grant - Using Mass cytometry to understand survival pathways in high-risk B-ALL subtypes.
Awarded AMP 2019 Tomorrow Maker.
Prizes and Awards
2022 Centre for Cancer Biology Early Career Researcher
2021 Australian Society of Medical Research SA meeting ECR presentation prize
2019 SAHMRI’s Annual Scientific meeting ECR presentation prize
- Co-supervision of 2 PhD students (both conferred 2022)
- 1 primary supervised Honours student (First Class) (2022)
- 3 co-supervised Honours students (First Class) (2017, 2020, 2021)
- 6 undergraduate placement students (2016-2024)
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2019 - 2022 | Co-Supervisor | Characterising KMT2A and MLLT10 Rearranged Acute Lymphoblastic Leukaemia | Doctor of Philosophy | Doctorate | Full Time | Miss Michelle Olivia Forgione |
| 2018 - 2022 | Co-Supervisor | Precision Medicine Approaches for JAK2-Rearranged Acute Lymphoblastic Leukaemia: The Efficacy of Targeted Therapies and Molecular Mechanisms of Drug Resistance | Doctor of Philosophy | Doctorate | Full Time | Miss Charlotte Emma-Jeane Toomes |
| Date | Role | Research Topic | Location | Program | Supervision Type | Student Load | Student Name |
|---|---|---|---|---|---|---|---|
| 2022 - 2022 | Principal Supervisor | Identification of therapeutically targetable pathways in EP300::ZNF384 rearranged B-cell Acute Lymphoblastic Leukaemia | SAHMRI / University of Adelaide | Adelaide Health and Medical Sciences | Honours | Full Time | Annabelle Dickens |
| 2019 - 2019 | Co-Supervisor | Characterising the contribution of disease-associated somatic variants in DEAD/H-Box Helicase 11 in B-cell Acute Lymphoblastic Leukemogenesis | SAHMRI | University of Adelaide, School of Biological Science | Honours | Full Time | Xhin Lin Ngo |
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