Barbara McClure

Barbara McClure

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Barbara McClure is a Post Doc in the Acute Lymphoblastic Leukaemia(ALL) Research group at SAHMRI. Dr McClure has extensive expertise in the structure and function of cytokine receptors, proteins that tightly regulate normal haematopoiesis and whose alterations can result in haematological malignancies. Her position within the ALL Research Team is focused on investigating Acute Lymphoblastic Leukaemia (ALL), an aggressive heamopoietic malignancy that is caused by a variety of genomic lesions. This research will focus on a new subtype of ALL, Ph-like ALL, which has an extremely poor prognosis. Using whole genome sequencing it has been identified that novel genetic fusions are present in the ALL patient samples. Dr McClure will be cloning these novel fusion genes and determining if the products of these fusion genes are the driving force responsible the uncontrolled leukaemic cell growth. Cell systems will then be developed to investigate the altered molecular events responsible for driving proliferation, and to determine if current therapeutics can abrogate the novel driver genes function. This work will help with improvement in the early diagnostic identification of ALL subtypes and to identify better therapeutic options for this aggressive disease.

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor Characterisation of the impact of cytokine profiles, the microbiome and innate immunity on the response of Acute Lymphoblastic Leukaemia (ALL) patients to contemporary therapies Doctor of Philosophy Doctorate Part Time Miss Stephanie Jade Field
    2018 Co-Supervisor Characterising signalling cascades and investigating therapeutic targets in JAK2-rearranged acute lymphoblastic leukaemia Doctor of Philosophy Doctorate Full Time Miss Charlotte Emma-Jeane Downes
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2022 Co-Supervisor Characterising KMT2A and MLLT10 Rearranged Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Miss Michelle Olivia Forgione
  • Other Supervision Activities

    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2019 - 2019 Co-Supervisor Characterising the contribution of disease-associated somatic variants in DEAD/H-Box Helicase 11 in B-cell Acute Lymphoblastic Leukemogenesis SAHMRI University of Adelaide, School of Biological Science Honours Full Time Xhin Lin Ngo
  • Committee Memberships

    Date Role Committee Institution Country
    2017 - ongoing Member SAHMRI Radiation Safety Committee SAHMRI Australia
  • Memberships

    Date Role Membership Country
    2021 - ongoing Member Heamatology Society of Australia and New Zealand (HSANZ) Australia
    2016 - ongoing Member Australian Society of Medical Research Australia
    2016 - ongoing Member Australian Epigenetics Alliance Australia

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