Barbara McClure
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Barbara McClure is a Post Doc in the Acute Lymphoblastic Leukaemia(ALL) Research group at SAHMRI. Dr McClure has extensive expertise in the structure and function of cytokine receptors, proteins that tightly regulate normal haematopoiesis and whose alterations can result in haematological malignancies. Her position within the ALL Research Team is focused on investigating Acute Lymphoblastic Leukaemia (ALL), an aggressive heamopoietic malignancy that is caused by a variety of genomic lesions. This research will focus on a new subtype of ALL, Ph-like ALL, which has an extremely poor prognosis. Using whole genome sequencing it has been identified that novel genetic fusions are present in the ALL patient samples. Dr McClure will be cloning these novel fusion genes and determining if the products of these fusion genes are the driving force responsible the uncontrolled leukaemic cell growth. Cell systems will then be developed to investigate the altered molecular events responsible for driving proliferation, and to determine if current therapeutics can abrogate the novel driver genes function. This work will help with improvement in the early diagnostic identification of ALL subtypes and to identify better therapeutic options for this aggressive disease.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
I am a mid-career researcher currently appointed as a Research Associate at The Centre for Cancer Biology in the Vascular Biology and Cell Trafficking Laboratory. I have significant experience studying haematological malignancies including genomics, molecular, receptor and cellular biology. I have published 53 peer reviewed articles receiving >1500 citations. My current research focus is understanding how a biomarker for poor prognosis Multiple Myeloma contributes to disease progression.
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Appointments
Date Position Institution name 2017 - ongoing Affiliate Lecturer University of Adelaide -
Education
Date Institution name Country Title 2017 University of Adelaide Australia PhD 1993 Univeristy of Adelaide Australia BSc(Hons) 1992 University of Adelaide Australia BSc -
Postgraduate Training
Date Title Institution Country HDR Supervisor course University of Adelaide Australia -
Certifications
Date Title Institution name Country 2016 Class B & C Radiation Licence Environment Protection Office - -
Research Interests
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Journals
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Conference Papers
Year Citation 2017 Broughton, S. E., Hercus, T., Nero, T., Dottore, M., McClure, B., Dhagat, U., . . . Parker, M. W. (2017). The GM-CSF Receptor - mechanisms for affinity conversion and signalling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C1279). INT UNION CRYSTALLOGRAPHY.
DOI2014 Broughton, S. E., Hercus, T., Nero, T., Dottore, M., McClure, B., Dhagat, U., . . . Parker, M. W. (2014). The GM-CSF Receptor - mechanisms for affinity conversion and signalling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C1279). INT UNION CRYSTALLOGRAPHY. 2014 Broughton, S. E., Hercus, T. R., Nero, T. L., Dhagat, U., Dottore, M., McClure, B. J., . . . Parker, M. W. (2014). Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex. In CYTOKINE Vol. 70 (pp. 32). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
DOI2014 Hercus, T. R., Broughton, S. E., Hardy, M. P., Nero, T. L., McClure, B. J., Dottore, M., . . . Lopez, A. F. (2014). Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123. In CYTOKINE Vol. 70 (pp. 46). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
DOI2009 Guthridge, M., Thomas, D., Barry, E. F., Chung, K. H., McClure, B. J., To, L. B., . . . Powell, J. A. (2009). Expression Profiling of a Hemopoietic Cell Survival Transcriptome Identifies a Functional Prognostic Gene Signature in Normal Karyotype AML.. In BLOOD Vol. 114 (pp. 647). New Orleans, LA: AMER SOC HEMATOLOGY. 2007 Lopez, A., Hercus, T., Hansen, G., Woodcock, J., McClure, B., Stomski, F., . . . Parker, M. P. (2007). The structure of the GM-CSF receptor ternary complex reveals a new, mode of cytokine receptor activation. In BLOOD Vol. 110 (pp. 35A). Atlanta, GA: AMER SOC HEMATOLOGY.
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Conference Items
Year Citation 2022 Thomson, A., Rehn, J., Heatley, S., Eadie, L., McClure, B., Page, E., . . . White, D. (2022). Benchmarking the detection rate of IGH gene fusions in B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) Conference. 2021 Heatley, S. L., Page, E. C., Eadie, L. N., McClure, B. J., Rehn, J., Yeung, D. T., . . . White, D. L. (2021). Modeling Relapsed, Refractory Acute Lymphoblastic Leukemia from a Child with Neurofibromatosis. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
DOI2021 Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 4th International T-ALL/T-NHL conference: T-ALL2020: Omics, genetics and therapy. 2021 McClure, B., Heatley, S., Grose, R., & White, D. (2021). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). 2021 Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). 2020 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Targeted pseudo-alignment technique for rapid and accurate identification of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of 14th Annual Florey Postgraduate Conference. Adelaide, South Australia. 2020 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Pseudo-alignment technique for accurate detection of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) 2020 National Conference. Canberra, ACT. 2020 Forgione, M. O., McClure, B. J., Eadie, L. N., & White, D. L. (2020). CD44 and its ligand osteopontin are upregulated specifically in KMT2A-AFF1 T-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. 2020 Eadie, L. N., Rehn, J., Heatley, S. L., McClure, B. J., Schutz, C. S., Breen, J., . . . White, D. L. (2020). Next Generation Genomic Analyses in T-ALL Patients Identify Recurrent and Novel Genomic Abnormalities. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
DOI WoS12020 Eadie, L., Heatley, S., McClure, B., Schutz, C., Breen, J., Hughes, T., . . . White, D. (2020). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. 2020 McClure, B., Heatley, S., Grose, R., Yeung, D., & White, D. (2020). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia.. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. 2020 Downes, C. E. J., McClure, B. J., Rehn, J., Breen, J., Bruning, J. B., Yeung, D. T., & White, D. L. (2020). Acquired Mutations within the JAK2 Kinase Domain Confer Resistance to JAK Inhibitors in an <i>in Vitro</i> model of a High-Risk Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
DOI WoS12019 Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of 1st European Society of Haematology (ESH) Translational Conference on ALL. Berlin, Germany. 2019 Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. 2019 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L., Schutz, C. E., . . . White, D. L. (2019). Investigating “alignment-free” computational techniques for the accurate identification of Acute Lymphoblastic Leukaemia (ALL) gene fusion events. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. 2019 Heatley, S. L., McClure, B. J., Eadie, L. N., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. 2019 Yeung, D., Greenwood, M., Rehn, J., Heatley, S., McClure, B., Eadie, L., . . . White, D. (2019). High risk genomic alterations identified at the time of diagnosis are strongly associated with MRD and subsequent poor outcomes in AYA ALL patients treated on a pediatric inspired chemotherapy regimen. Poster session presented at the meeting of Blood. Orlando, CA: American Society of Hematology.
DOI2018 Downes, C., McClure, B., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland. 2018 Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . . . White, D. L. (2018). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of 23rd Congress of European Hematology Association. Stockholm, Sweden. 2018 Downes, C. E., McClure, B. J., Heatley, S. L., Yeung, D. T., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of NDLR. 2018 Heatley, S. L., McClure, B. J., Kok, C., Sadras, T., Dang, P., Galbraith, K., . . . White, D. L. (2018). Exploring the genomic diversity of adult and AYA cases with high-risk B-ALL by mRNA sequencing. Poster session presented at the meeting of NDLR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of APG Student Awards. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk JAK2 fusion in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and Characterisation of Ruxolitinib Resistant Mutations in JAK2-rearranged B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of AGTA. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of mutations that cause ruxolitinib resistance in Pro-B cells driven by a high-risk B-ALL JAK2-fusion.. Poster session presented at the meeting of ANZCHOG. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of SAHMRI Scientific Seminar. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium. 2017 McClure, B. J., Heatley, S. L., Kok, C., Sadras, T., An, J., Quek, K., . . . White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult pre-B-ALL patients. Poster session presented at the meeting of ANZCHOG. 2017 Heatley, S. L., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. L. (2017). High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk-Adapted Treatment. Poster session presented at the meeting of ANZCHOG. 2017 McClure, B. J., Heatley, S. L., Sadras, T., Sutton, R., & White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult Australian pre-B-acute lymphoblastic leukaemia. Poster session presented at the meeting of IBFM. 2017 Downes, C. E., McClure, B. M., Heatley, S. H., Sadras, T. S., Hughes, T. H., Kok, C. K., . . . White, D. W. (2017). Identification and cloning of a novel GOLGA4-JAK2 fusion from an adult patient with B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster session presented at the ASMR SA Scientific Meeting. Adelaide. 2016 White, D. L., McClure, B., Heatley, S., Sadras, T., Quek, K., & Hughes, T. (2016). Investigation of the transforming capacity of a recently identified EP300-ZNF384 fusion gene in adult acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Galbraith, K., Sadras, T., McClure, B., Heatley, S., & White, D. L. (2016). Identification of novel therapeutic targets in CRLF2 rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Heatley, S., Sadras, T., McClure, B., Kok, C. H., Dang, P., Nievergall, E., . . . White, D. L. (2016). The Incidence of Ph-like Acute Lymphoblastic Leukaemia (ALL) Increases with Age and is Characterised by Poor Outcome. Poster session presented at the meeting of Poster Session. Melbourne, VIC. -
Theses
Year Citation 2017 Downes, C. E. (2017). Cloning, Signalling Characterisation and JAK2 Inhibitor-Resistance of Two JAK2 Fusions in High-Risk B-ALL. (Undergraduate Dissertation).
Grants:
2019 AMP Tomorrow Makers Grant ($22,500) as CIA
2023 CUREator grant – MRFF funded scheme ($650,000) as CIB with Prof Claudine Bonder (CIA) and now acting as a Scientific Advisor for the startup company that this funding supports.
Prizes and Awards
2019 SAHMRI’s Annual Scientific meeting ECR presentation prize
2021 Australian Society of Medical Research SA meeting ECR presentation prize
2022 Centre for Cancer Biology Early Career Researcher
- Co-supervision of 2 PhD students (both conferred 2022)
- 1 primary supervised Honours student (First Class) (2022)
- 3 co-supervised Honours students (First Class) (2017, 2020, 2021)
- 6 undergraduate placement students (2016-2024)
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2022 Co-Supervisor Characterising KMT2A and MLLT10 Rearranged Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Miss Michelle Olivia Forgione 2018 - 2022 Co-Supervisor Precision Medicine Approaches for JAK2-Rearranged Acute Lymphoblastic Leukaemia: The Efficacy of Targeted Therapies and Molecular Mechanisms of Drug Resistance Doctor of Philosophy Doctorate Full Time Miss Charlotte Emma-Jeane Downes -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2022 - 2022 Principal Supervisor Identification of therapeutically targetable pathways in EP300::ZNF384 rearranged B-cell Acute Lymphoblastic Leukaemia SAHMRI / University of Adelaide Adelaide Health and Medical Sciences Honours Full Time Annabelle Dickens 2019 - 2019 Co-Supervisor Characterising the contribution of disease-associated somatic variants in DEAD/H-Box Helicase 11 in B-cell Acute Lymphoblastic Leukemogenesis SAHMRI University of Adelaide, School of Biological Science Honours Full Time Xhin Lin Ngo
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Committee Memberships
Date Role Committee Institution Country 2017 - ongoing Member SAHMRI Radiation Safety Committee SAHMRI Australia -
Memberships
Date Role Membership Country 2021 - ongoing Member Heamatology Society of Australia and New Zealand (HSANZ) Australia 2016 - ongoing Member Australian Society of Medical Research Australia 2016 - ongoing Member Australian Epigenetics Alliance Australia
Connect With Me
External Profiles
