Professor Andrew Abell

Andrew Abell
Professor
School of Physical Sciences
Faculty of Sciences

Andrew graduated from the University of Adelaide with BSc(Hon) and PhD and then undertook a postdoctoral fellowship at the University of Cambridge. He held a professorship at the University of Canterbury before returning to the University of Adelaide in 2007, where he is currently Professor of Chemistry and node director of the ARC Centre of Excellence for Nanoscale Biophotonics. His research interests are concerned with understanding the fundamental link between the chemical structure and shape of key biological molecules and their biological function. While his work is very much driven by fundamental science, he has always had a keen interest in pursuing associated commercial opportunities. The seed for this was sown with a sabbatical leave working as a visiting scientist, consultant and senior Fulbright Fellow with SmithKline Beecham (now GSK) in Philadelphia. In Adelaide he co-founded an Adelaide-based company (Calpain Therapeutics) to develop macrocyclic protease inhibitors as a potential treatment for cataract and other conditions. Past member of ARC College of Experts and Head of School of Chemistry and Physics at the University of Adelaide and also recent recipient of the Royal Australian Chemical Institute Adrien Albert Prize and the Alexander R. Matzuk Prize and Lecture in Drug Discovery (Baylor College of Medicine, Houston).

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Professor Andrew Abell

Andrew graduated from the University of Adelaide with BSc(Hon) and PhD and then undertook a postdoctoral fellowship at the University of Cambridge. He held a professorship at the University of Canterbury before returning to the University of Adelaide in 2007, where he is currently Professor of Chemistry and node director of the ARC Centre of Excellence for Nanoscale Biophotonics. His research interests are concerned with understanding the fundamental link between the chemical structure and shape of key biological molecules and their biological function. While his work is very much driven by fundamental science, he has always had a keen interest in pursuing associated commercial opportunities. The seed for this was sown with a sabbatical leave working as a visiting scientist, consultant and senior Fulbright Fellow with SmithKline Beecham (now GSK) in Philadelphia. In Adelaide he co-founded an Adelaide-based company (Calpain Therapeutics) to develop macrocyclic protease inhibitors as a potential treatment for cataract and other conditions. Past member of ARC College of Experts and Head of School of Chemistry and Physics at the University of Adelaide and also recent recipient of the Royal Australian Chemical Institute Adrien Albert Prize and the Alexander R. Matzuk Prize and Lecture in Drug Discovery (Baylor College of Medicine, Houston).

The focus of our extended group is concerned with the design, synthesis, and exploitation of small molecule enzyme inhibitors and mimics of key biological compounds. These compounds provide a basis of new therapeutics for the treatment of cancer and other diseases, as well as probes to study key metabolic processes such as electron transfer. They can also be attached to surfaces to provide functional materials and biosensors.

Please see our Group webpage: http://physsci.adelaide.edu.au/bomcl/

Please also see the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP): http://cnbp.org.au/

Please also see Calpain Therapeutics: http://www.calpaintherapeutics.com/

Do you want to join our research group?

PhD Scholarships

University scholarships for Australian students are known as Australian Postgraduate Awards (APA). These scholarships are awarded on the basis of academic merit and in designated areas of research strength within the University. If a student does not secure an APA, then the School of Physical Sciences considers the option of divisional scholarships (based on academic merit and budget limits). The University also offers a range of Scholarships for international students.

Application involves filling in the "application form for admission/scholarship".

When applying for domestic scholarships please remember to tick both the APA and Divisional box.  After the closing date, the Graduate Centre will forward your application to the School to consider. If an APA is not awarded then the school will consider offering a divisional scholarship.  Further details can be found at the scholarship websites http://www.adelaide.edu.au/scholarships/

Further information on international PhD scholarships can be found at:  https://www.adelaide.edu.au/graduatecentre/scholarships/research-international/opportunities/

Postdoctoral Positions

Postdoctoral positions arise from time to time, so if you're interested please get in touch and we'll get back to you ASAP.

Appointments

Date Position Institution name
2014 Adelaide Node Leader Centre for Nanosale BioPhotonics (CNBP)
2013 - 2014 Head of School of Chemistry and Physics The University of Adelaide
2011 Chief Scientific Advisor Calpain Therapeutics
2007 Adjunct Professor Lincoln University (New Zealand)
2007 Professor University of Adelaide
2007 Adjunct Professor University of Canterbury
2001 - 2007 Professor University of Canterbury
1993 - 1994 Visiting Scientist and Fulbright Scientist SmithKline Beecham
1985 - 1987 Postdoctoral Fellow University of Cambridge

Awards and Achievements

Date Type Title Institution Name Amount
2013 Award Alexander R. Matzuk Prize and Lecture in Drug Discovery
2012 Award Adrien Albert Prize
2011 Award The University of Queensland Business School's Enterprize
2010 Distinction Adjunct Professor at the University of Canterbury Lincoln University
2007 Honour Adjunct Professor at the University of Canterbury
2007 Distinction Fellow of Royal Australian Institute of Chemistry
2004 Distinction Elected Member of the New Zealand Centre for Molecular Biodiscovery CoRE
2003 Fellowship University of Canterbury Erskine Fellowship
2002 Distinction Elected member of the New Zealand MacDiarmid Institute for Advanced Materials and Nanotechnology CoRE
2001 Fellowship University of Canterbury Erskine Fellowship
2000 Honour Elected member of the American Chemical Society
1998 Award Royal Society of Chemistry Journals Grants for international Authors
1997 Invitation Invited Editor for JAI Press, London and Connecticut
1995 Award Easterfield medal
1995 Distinction Fellow of New Zealand Institute of Chemistry (FNZIC)
1993 Distinction 12 month visiting scientist SmithKline Beecham Pharmaceuticals USA
1993 Award Fulbright Fellow
1985 Research Award George Murray Scholarship
1981 Award C.S.R. Chemicals Prize

Journals

Year Citation
2017 Yu, J., Horsley, J. & Abell, A. (2017). A controllable mechanistic transition of charge transfer in helical peptides: From hopping to superexchange. RSC Advances, 7, 67, 42370-42378.
10.1039/c7ra07753j
2017 Yu, J., Horsley, J. & Abell, A. (2017). Exploiting the interplay of quantum interference and backbone rigidity on electronic transport in peptides: a step towards bio-inspired quantum interferometers. Molecular Systems Design &​ Engineering, 2, 1, 67-77.
10.1039/C6ME00077K
2017 Heng, S., Zhang, X., Pei, J. & Abell, A. (2017). A Rationally designed reversible 'turn-off' sensor for glutathione. Biosensors, 7, 3, 36-36.
10.3390/bios7030036
2017 Heng, S., Mak, A., Kostecki, R., Zhang, X., Pei, J., Stubing, D. ... Abell, A. (2017). Photoswitchable calcium sensor: ‘On’–‘Off’ sensing in cells or with microstructured optical fibers. Sensors and Actuators, B: Chemical, 252, 965-972.
10.1016/j.snb.2017.06.051
2017 Stubing, D. B., Heng, S., Monro, T. M. & Abell, A. D. (2017). A comparative study of the fluorescence and photostability of common photoswitches in microstructured optical fibre. Sensors and Actuators B: Chemical, 239, 474-480.
10.1016/j.snb.2016.07.172
2017 Pehere, A., Zhang, X. & Abell, A. (2017). Macrocyclic Peptidomimetics Prepared by Ring-Closing Metathesis and Azide-Alkyne Cycloaddition. Australian Journal of Chemistry, 70, 2, 138-151.
10.1071/CH16532
2017 Law, C., Sylvia, G., Nemati, M., Yu, J., Losic, D., Abell, A. & Santos, A. (2017). Engineering of surface chemistry for enhanced sensitivity in nanoporous interferometric sensing platforms. ACS Applied Materials and Interfaces, 9, 10, 8929-8940.
10.1021/acsami.7b01116
2017 McDowall, M., Gosnell, M., Anwer, A., White, M., Purdey, M., Abell, A. ... Thompson, J. (2017). Hyperspectral microscopy can detect metabolic heterogeneity within bovine post-compaction embryos incubated under two oxygen concentrations (7% versus 20%). Human Reproduction, 32, 10, 2016-2025.
10.1093/humrep/dex261
2017 Frkic, R., He, Y., Rodriguez, B., Chang, M., Kuruvilla, D., Ciesla, A. ... Bruning, J. (2017). Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. Journal of Medicinal Chemistry, 60, 11, 4584-4593.
10.1021/acs.jmedchem.6b01727
2017 Blanco, B., Palasis, K., Adwal, A., Callen, D. & Abell, A. (2017). Azobenzene-containing photoswitchable proteasome inhibitors with selective activity and cellular toxicity. Bioorganic and Medicinal Chemistry, 25, 19, 5050-5054.
10.1016/j.bmc.2017.06.011
2017 Heng, S., Reineck, P., Vidanapathirana, A., Pullen, B., Drumm, D., Ritter, L. ... Abell, A. (2017). Rationally Designed Probe for Reversible Sensing of Zinc and Application in Cells. ACS Omega, 2, 9, 6201-6210.
10.1021/acsomega.7b00923
2016 Zhang, X., Adwal, A., Turner, A., Callen, D. & Abell, A. (2016). New peptidomimetic boronates for selective inhibition of the chymotrypsin-like activity of the 26S proteasome. ACS Medicinal Chemistry Letters, 7, 12, 1039-1043.
10.1021/acsmedchemlett.6b00217
2016 Heng, S., McDevitt, C., Kostecki, R., Morey, J., Eijkelkamp, B., Ebendorff-Heidepriem, H. ... Abell, A. (2016). Microstructured optical fiber-based biosensors: reversible and nanoliter-scale measurement of zinc ions. ACS Applied Materials and Interfaces, 8, 20, 12727-12732.
10.1021/acsami.6b03565
2016 Feng, J., Paparella, A., Booker, G., Polyak, S. & Abell, A. (2016). Biotin protein ligase is a target for new antibacterials. Antibiotics, 5, 3, 26-1-26-15.
10.3390/antibiotics5030026
2016 Yu, J., Horsley, J. & Abell, A. (2016). Turning electron transfer 'on-off' in peptides through side-bridge gating. Electrochimica Acta, 209, 65-74.
10.1016/j.electacta.2016.05.067
2016 Cottam Jones, J., Harris, P., Scanlon, D., Forbes, B., Brimble, M. & Abell, A. (2016). Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R. Organic and Biomolecular Chemistry, 14, 9, 2698-2705.
10.1039/c5ob02110c
2016 Keeling, K., Cho, O., Scanlon, D., Booker, G., Abell, A. & Wegener, K. (2016). The key position: influence of staple location on constrained peptide conformation and binding. Organic & Biomolecular Chemistry, 14, 41, 9731-9735.
10.1039/c6ob01745b
2016 Stubing, D., Heng, S. & Abell, A. (2016). Crowned spiropyran fluoroionophores with a carboxyl moiety for the selective detection of lithium ions. Organic and Biomolecular Chemistry, 14, 15, 3752-3757.
10.1039/c6ob00468g
2016 Zuber, A., Purdey, M., Schartner, E., Forbes, C., Van Der Hoek, B., Giles, D. ... Ebendorff-Heidepriem, H. (2016). Detection of gold nanoparticles with different sizes using absorption and fluorescence based method. Sensors and Actuators, B: Chemical, 227, 117-127.
10.1016/j.snb.2015.12.044
2016 Greenwood, J., Tan, J., Choong Tzen Ming, J. & Abell, A. (2016). Alkalis and skin. Journal of Burn Care and Research, 37, 2, 135-141.
10.1097/BCR.0000000000000222
2016 Feng, J., Paparella, A., Tieu, W., Heim, D., Clark, S., Hayes, A. ... Abell, A. (2016). New series of BPL inhibitors to probe the ribose-binding pocket of Staphylococcus aureus biotin protein ligase. ACS Medicinal Chemistry Letters, 7, 12, 1068-1072.
10.1021/acsmedchemlett.6b00248
2016 Carpenter, R., Holman, A., Abell, A. & Grice, K. (2016). Cretaceous fire in Australia: a review with new geochemical evidence, and relevance to the rise of the angiosperms. Australian Journal of Botany, 64, 8, 564-578.
10.1071/BT16109
2016 Zhang, X., Bruning, J., George, J. & Abell, A. (2016). A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde. Organic and Biomolecular Chemistry, 14, 29, 6970-6978.
10.1039/c6ob01159d
2016 Sutton-McDowall, M., Wu, L., Purdey, M., Abell, A., Goldys, E., MacMillan, K. ... Robker, R. (2016). Non-esterified fatty acid-induced endoplasmic reticulum stress in cattle cumulus oocyte complexes alters cell metabolism and developmental competence. Biology of Reproduction, 94, 1, 23 -1-23 -9.
10.1095/biolreprod.115.131862
2015 Schartner, E., Tsiminis, G., François, A., Kostecki, R., Warren-Smith, S., Nguyen, L. ... Monro, T. (2015). Taming the light in microstructured optical fibers for sensing. International Journal of Applied Glass Science, 6, 3, 229-239.
10.1111/ijag.12128
2015 Kumeria, T., Yu, J., Alsawat, M., Kurkuri, M., Santos, A., Abell, A. & Losic, D. (2015). Membranes: Photoswitchable Membranes Based on Peptide-Modified Nanoporous Anodic Alumina: Toward Smart Membranes for On-Demand Molecular Transport (Adv. Mater. 19/2015). Advanced materials, 27, 19, 2950-2950.
10.1002/adma.201570127
2015 Tieu, W., Polyak, S., Paparella, A., Yap, M., Soares Da Costa, T., Ng, B. ... Abell, A. (2015). Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery. ACS Medicinal Chemistry Letters, 6, 2, 216-220.
10.1021/ml500475n
2015 Sutton-McDowall, M., Purdey, M., Brown, H., Abell, A., Mottershead, D., Cetica, P. ... Thompson, J. (2015). Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone. Molecular Reproduction and Development, 82, 4, 281-294.
10.1002/mrd.22470
2015 Purdey, M., Connaughton, H., Whiting, S., Schartner, E., Monro, T., Thompson, J. ... Abell, A. (2015). Boronate probes for the detection of hydrogen peroxide release from human spermatozoa. Free Radical Biology & Medicine, 81, 69-76.
10.1016/j.freeradbiomed.2015.01.015
2015 Purdey, M., Thompson, J., Monro, T., Abell, A. & Schartner, E. (2015). A dual sensor for pH and hydrogen peroxide using polymer-coated optical fibre tips. Sensors, 15, 12, 31904-31913.
10.3390/s151229893
2015 Horsley, J., Yu, J. & Abell, A. (2015). The correlation of electrochemical measurements and molecular junction conductance simulations in β-strand peptides. Chemistry, 21, 15, 5926-5933.
10.1002/chem.201406451
2015 Kumeria, T., Yu, J., Alsawat, M., Kurkuri, M., Santos, A., Abell, A. & Losic, D. (2015). Photoswitchable membranes based on peptide-modified nanoporous anodic alumina: toward smart membranes for on-demand molecular transport. Advanced Materials, 27, 19, 3019-3024.
10.1002/adma.201500473
2015 Zhang, X., Heng, S. & Abell, A. (2015). Photoregulation of α-chymotrypsin activity by spiropyran-based inhibitors in solution and attached to an optical fiber. Chemistry, 21, 30, 10703-10713.
10.1002/chem.201501488
2014 Jones, S. A., Duncan, J., Aitken, S. G., Coxon, J. M. & Abell, A. D. (2014). The preparation of macrocyclic calpain inhibitors by ring closing metathesis and cross metathesis. Australian Journal of Chemistry, 67, 9, 1257-1263.
10.1071/CH14121
2014 Yu, J., Horsley, J., Moore, K., Shapter, J. & Abell, A. (2014). The effect of a macrocyclic constraint on electron transfer in helical peptides: a step towards tunable molecular wires. Chemical Communications, 50, 14, 1652-1654.
10.1039/C3CC47885H
2014 Chua, K., Pietsch, M., Zhang, X., Hautmann, S., Chan, H., Bruning, J. ... Abell, A. (2014). Macrocyclic protease inhibitors with reduced peptide character. Angewandte Chemie International Edition, 53, 30, 7828-7831.
10.1002/anie.201404301
2014 Soares da Costa, T., Yap, M., Perugini, M., Wallace, J., Abell, A., Wilce, M. ... Booker, G. (2014). Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus. Molecular Microbiology, 91, 1, 110-120.
10.1111/mmi.12446
2014 Tieu, W., Jarrad, A., Paparella, A., Keeling, K., Soares da Costa, T., Wallace, J. ... Abell, A. (2014). Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase. Bioorganic & Medicinal Chemistry Letters, 24, 19, 4689-4693.
10.1016/j.bmcl.2014.08.030
2014 Horsley, J., Yu, J., Moore, K., Shapter, J. & Abell, A. (2014). Unraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires. Journal of the American Chemical Society, 136, 35, 12479-12488.
10.1021/ja507175b
2014 Paparella, A., Soares Da Costa, T., Yap, M., Tieu, W., Wilce, M., Booker, G. ... Polyak, S. (2014). Structure guided design of biotin protein ligase inhibitors for antibiotic discovery. Current Topics in Medicinal Chemistry, 14, 1, 4-20.
10.2174/1568026613666131111103149
2014 Heng, S., Mak, A., Stubing, D., Monro, T. & Abell, A. (2014). Dual sensor for Cd(II) and Ca(II): selective nanoliter-scale sensing of metal ions. Analytical Chemistry, 86, 7, 3268-3272.
10.1021/ac500619z
2014 Pendini, N., Yap, M., Polyak, S., Cowieson, N., Abell, A., Booker, G. ... Wilce, M. (2014). Erratum: Structural characterisation of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target (Protein Science (2013) 22 (762-773)). Protein Science, 23, 1, 121-.
10.1002/pro.2399
2013 Moore, K., Flavel, B., Yu, J., Abell, A. & Shapter, J. (2013). Increased redox-active peptide loading on carbon nanotube electrodes. Electrochimica Acta, 89, 206-211.
10.1016/j.electacta.2012.10.108
2013 Pendini, N., Yap, M., Polyak, S., Cowieson, N., Abell, A., Booker, G. ... Wilce, M. (2013). Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target. Protein Science, 22, 6, 762-773.
10.1002/pro.2262
2013 Heng, S., Nguyen, M. C., Kostecki, R., Monro, T. & Abell, A. (2013). Nanoliter-scale, regenerable ion sensor: sensing with a surface functionalized microstructured optical fibre. RSC Advances, 3, 22, 8308-8317.
10.1039/c3ra40321a
2013 Pehere, A., Sumby, C. & Abell, A. (2013). New cylindrical peptide assemblies defined by extended parallel β-sheets. Organic & Biomolecular Chemistry, 11, 3, 425-429.
10.1039/C2OB26637G
2013 Cottam, J., Scanlon, D., Karas, J., Calabrese, A., Pukala, T., Forbes, B. ... Abell, A. (2013). Chemical synthesis of a fluorescent IGF-II analogue. International Journal of Peptide Research and Therapeutics, 19, 1, 61-69.
10.1007/s10989-012-9339-3
2013 Pehere, A., Pietsch, M., Gutschow, M., Neilsen, P., Pedersen, D., Nguyen, S. ... Abell, A. (2013). Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors. Chemistry-A European Journal, 19, 24, 7975-7981.
10.1002/chem.201204260
2013 Yu, J., Horsley, J. & Abell, A. (2013). The influence of secondary structure on electron transfer in peptides. Australian Journal of Chemistry, 66, 8, 848-851.
10.1071/CH13276
2013 Neilsen, P., Pehere, A., Pishas, K., Callen, D. & Abell, A. (2013). New 26S proteasome inhibitors with high selectivity for chymotrypsin-like activity and p53-dependent cytotoxicity. ACS Chemical Biology, 8, 2, 353-359.
10.1021/cb300549d
2013 Tieu, W., Soares da Costa, T., Yap, M., Keeling, K., Wilce, M., Wallace, J. ... Abell, A. (2013). Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitors. Chemical Science, 4, 9, 3533-3537.
10.1039/c3sc51127h
2013 Jones, S., Neilsen, P., Siew, L., Callen, D., Goldfarb, N., Dunn, B. & Abell, A. (2013). A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease. ChemMedChem, 8, 12, 1918-1921.
10.1002/cmdc.201300387
2013 Heng, S., McDevitt, C., Stubing, D., Whittall, J., Thompson, J., Engler, T. ... Monro, T. (2013). Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules, 14, 10, 3376-3379.
10.1021/bm401040v
2013 Morton, J., Lee, H., McDermott, J., Robertson, L., Bickerstaffe, R., Jones, M. ... Abell, A. (2013). A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model. Investigative Ophthalmology and Visual Science, 54, 1, 389-395.
10.1167/iovs.12-11088
2013 Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Stanley, N. ... Somogyi, A. (2013). The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metabolism and Disposition, 41, 6, 1264-1272.
10.1124/dmd.113.051631
2012 Soares da Costa, T., Tieu, W., Yap, M., Pendini, N., Polyak, S., Pedersen, D. ... Abell, A. (2012). Selective inhibition of biotin protein ligase from Staphylococcus aureus. Journal of Biological Chemistry, 287, 21, 17823-17832.
10.1074/jbc.M112.356576
2012 Chen, H., Jiao, W., Jones, M., Coxon, J., Morton, J., Bickerstaffe, R. ... Abell, A. (2012). New tripeptide-based macrocyclic calpain inhibitors formed by n-alkylation of histidine. Chemistry & Biodiversity, 9, 11, 2473-2484.
10.1002/cbdv.201200320
2012 Yu, J., Huang, D., Shapter, J. & Abell, A. (2012). Electrochemical and computational studies on intramolecular dissociative electron transfer in β‐peptides. Journal of Physical Chemistry C, 116, 50, 26608-26617.
10.1021/jp3082563
2012 Peddie, V. & Abell, A. (2012). A study on the diastereoselective synthesis of α-fluorinated β³-amino acids by α-fluorination. Helvetica Chimica Acta, 95, 12, 2460-2473.
10.1002/hlca.201200520
2012 Soares da Costa, T., Tieu, W., Yap, M., Zvarec, O., Bell, J., Turnidge, J. ... Polyak, S. (2012). Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase. ACS Medicinal Chemistry Letters, 3, 6, 509-514.
10.1021/ml300106p
2012 Yu, J., Zvarec, O., Huang, D., Bissett, M., Scanlon, D., Shapter, J. & Abell, A. (2012). Electron transfer through α-peptides attached to vertically aligned carbon nanotube arrays: a mechanistic transition. Chemical Communications, 48, 8, 1132-1134.
10.1039/c2cc16665h
2012 Zvarec, O., Polyak, S., Tieu, W., Kuan, K., Dai, H., Pedersen, D. ... Abell, A. (2012). 5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials. Bioorganic & Medicinal Chemistry Letters, 22, 8, 2720-2722.
10.1016/j.bmcl.2012.02.100
2012 Polyak, S., Abell, A., Wilce, M., Zhang, L. & Booker, G. (2012). Structure, function and selective inhibition of bacterial acetyl-coa carboxylase. Applied Microbiology and Biotechnology, 93, 3, 983-992.
10.1007/s00253-011-3796-z
2012 Pehere, A. & Abell, A. (2012). New β-strand templates constrained by Huisgen cycloaddition. Organic Letters, 14, 5, 1330-1333.
10.1021/ol3002199
2012 Peddie, V., Butcher, R., Robinson, W., Wilce, M., Traore, D. & Abell, A. (2012). Synthesis and conformation of fluorinated β-peptidic compounds. Chemistry-A European Journal, 18, 21, 6655-6662.
10.1002/chem.201200313
2011 Packwood, D., Brooksby, P., Abell, A. & Downard, A. (2011). pH-dependent wettability of carboxyphenyl films grafted to glassy carbon. Australian Journal of Chemistry, 64, 1, 122-126.
10.1071/CH10285
2011 Ellis-Steinborner, S., Scanlon, D., Musgrave, I., Tran, T., Hack, S., Wang, T. ... Bowie, J. (2011). An unusual kynurenine-containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 25, 12, 1735-1740.
10.1002/rcm.5041
2011 Pedersen, D. & Abell, A. (2011). 1,2,3-triazoles in peptidomimetic chemistry. European Journal of Organic Chemistry, 2011, 13, 2399-2411.
10.1002/ejoc.201100157
2011 Zaman, S., Chen, H. & Abell, A. (2011). Studies of a soluble polyethylene glycol immobilized ruthenium catalyst in aqueous media. Tetrahedron Letters, 52, 8, 878-880.
10.1016/j.tetlet.2010.12.046
2011 Wang, T., Tran, T., Scanlon, D., Andreazza, H., Abell, A. & Bowie, J. (2011). Diagnostic di- and triphosphate cyclisation in the negative ion electrospray mass spectra of phosphoSer peptides. Rapid Communications in Mass Spectrometry, 25, 18, 2649-2656.
10.1002/rcm.5171
2011 Lim, S., Neilsen, P., Sharma, R., Abell, A. & Callen, D. (2011). The application of delivery systems for DNA methyltransferase inhibitors. Biodrugs, 25, 4, 227-242.
10.2165/11592770-000000000-00000
2011 Stuart, B., Coxon, J., Morton, J., Abell, A., McDonald, D., Aitken, S. ... Bickerstaffe, R. (2011). Molecular modeling: A search for a calpain inhibitor as a new treatment for cataractogenesis. Journal of Medicinal Chemistry, 54, 21, 7503-7522.
10.1021/jm200471r
2011 Pehere, A. & Abell, A. (2011). Selective N-acylation and N-alkylation of biotin. Journal of Organic Chemistry, 76, 22, 9514-9518.
10.1021/jo201615j
2011 Warren-Smith, S., Heng, S., Ebendorff-Heidepriem, H., Abell, A. & Monro, T. (2011). Fluorescence-Based Aluminum Ion Sensing using a Surface Functionalized Microstructured Optical Fiber. Langmuir, 27, 9, 5680-5685.
10.1021/la2002496
2011 Pehere, A. & Abell, A. (2011). An improved large scale procedure for the preparation of N-Cbz amino acids. Tetrahedron Letters, 52, 13, 1493-1494.
10.1016/j.tetlet.2011.01.102
2011 Brooksby, P., Anderson, K., Downard, A. & Abell, A. (2011). Voltammetric and electrochemical impedance study of ferrocenyl containing beta-peptide monolayers on gold. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces, 115, 15, 7516-7526.
10.1021/jp112278g
2011 Heng, S., Tieu, W., Hautmann, S., Kuan, K., Pedersen, D., Pietsch, M. ... Abell, A. (2011). New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds. Bioorganic & Medicinal Chemistry, 19, 24, 7453-7463.
10.1016/j.bmc.2011.10.042
2010 Brooksby, P., Anderson, K., Downard, A. & Abell, A. (2010). Electrochemistry of ferrocenoyl β-peptide monolayers on gold. Langmuir, 26, 2, 1334-1339.
10.1021/la902402t
2010 Peddie, V., Pietsch, M., Bromfield, K., Pike, R., Duggan, P. & Abell, A. (2010). Fluorinated β²- and β³-amino acids: synthesis and inhibition of α-chymotrypsin. Synthesis-Stuttgart, 2010, 11, 1845-1859.
10.1055/s-0029-1218743
2010 Stanley, N., Pedersen, D., Nielsen, B., Kvist, T., Mathiesen, J., Brauner-Osborne, H. ... Abell, A. (2010). 1,2,3-Triazolyl amino acids as AMPA receptor ligands. Bioorganic & Medicinal Chemistry Letters, 20, 24, 7512-7515.
10.1016/j.bmcl.2010.09.139
2010 Pearson, D. & Abell, A. (2010). Structural optimization of photoswitch ligands for surface attachment of α-chymotrypsin and regulation of its surface binding. Chemistry-A European Journal, 16, 23, 6983-6992.
10.1002/chem.200903369
2010 Pietsch, M., Chua, K. & Abell, A. (2010). Calpains: Attractive targets for the development of synthetic inhibitors. Current Topics in Medicinal Chemistry, 10, 3, 270-293.
10.2174/156802610790725489
2010 Ballet, S., Marczak, E., Feytens, D., Salvadori, S., Sasaki, Y., Abell, A. ... Tourwe, D. (2010). Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. Bioorganic & Medicinal Chemistry Letters, 20, 5, 1610-1613.
10.1016/j.bmcl.2010.01.055
2010 Stanley, N., Hutchinson, M., Kvist, T., Nielsen, B., Mathiesen, J., Brauner-Osborne, H. ... Taylor, D. (2010). A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry, 18, 16, 6089-6098.
10.1016/j.bmc.2010.06.051
2009 Abell, A., Alexander, N., Aitken, S., Chen, H., Coxon, J., Jones, M. ... Muscroft-Taylor, A. (2009). Synthesis of macrocyclic β-Strand memplates by ring closing metathesis. Journal of Organic Chemistry, 74, 11, 4354-4356.
10.1021/jo802723w
2009 Ebert, M. O., Gardiner, J., Ballet, S., Abell, A. & Seebach, D. (2009). Synthesis and high-resolution NMR structure of a β³-octapeptide with and without a tether introduced by olefin metathesis. Helvetica Chimica Acta, 92, 12, 2643-2658.
10.1002/hlca.200900311
2009 Jones, S., Jones, M., McNabb, S., Aitken, S., Coxon, J. & Abell, A. (2009). N-heterocyclic dipeptide aldehyde calpain inhibitors. Protein and Peptide Letters, 16, 12, 1466-1472.
10.2174/092986609789839296
2009 Abell, A., Jones, M., Coxon, J., Morton, J., Aitken, S., McNabb, S. ... Bickerstaffe, R. (2009). Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors. Angewandte Chemie-International Edition, 48, 8, 1455-1458.
10.1002/anie.200805014
2009 Zaman, S. & Abell, A. (2009). A robust and recyclable ruthenium catalyst immobilised on polyethylene glycol. Tetrahedron Letters, 50, 38, 5340-5343.
10.1016/j.tetlet.2009.07.022
2009 Zaman, S., Curnow, O. & Abell, A. (2009). Development of Aqueous Metathesis Catalysts. Australian Journal of Chemistry, 62, 2, 91-100.
10.1071/CH08470
2009 Jones, M., Coxon, J., McNabb, S., Mehrtens, J., Alexander, N., Jones, S. ... Abell, A. (2009). Efficient Large-Scale Synthesis of CAT811, a Potent Calpain Inhibitor of Interest in the Treatment of Cataracts. Australian Journal of Chemistry, 62, 7, 671-675.
10.1071/CH09101
2008 Vernall, A., Ballet, S. & Abell, A. (2008). Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates. Tetrahedron, 64, 18, 3980-3997.
10.1016/j.tet.2008.02.043
2008 Pearson, D. & Abell, A. (2008). D-Leu-L-Phe-containing dipeptide inhibitors of -chymosrypsin- the role of the N- and C-termini in enzyme affinity. ARKIVOC, 2008, 12, 85-93.
2008 Jones, M., Morton, J., Coxon, J., McNabb, S., Lee, H., Aitken, S. ... Abell, A. (2008). Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorganic & Medicinal Chemistry, 16, 14, 6911-6923.
10.1016/j.bmc.2008.05.048
2008 Brooksby, P., Schiel, D. & Abell, A. (2008). Electrochemistry of catechol terminated monolayers with Cu(II), Ni(II) and, Fe(III) cations: A model for the marine adhesive interface. Langmuir, 24, 16, 9074-9081.
10.1021/la8007816
2008 Pearson, D., Alexander, N. & Abell, A. (2008). Improved photocontrol of alpha-chymotrypsin activity: Peptidomimetic trifluoromethylketone photoswitch enzyme inhibitors. Chemistry-A European Journal, 14, 24, 7358-7365.
10.1002/chem.200800082
2008 Ballet, S., Pietsch, M. & Abell, A. (2008). Multiple ligands in opioid research. Protein and Peptide Letters, 15, 7, 668-682.
10.2174/092986608785133672
2008 Lee, H., Morton, J., Robertson, L., McDermott, J., Bickerstaffe, R., Abell, A. ... Coxon, J. (2008). Evaluation of a novel calpain inhibitor as a treatment for cataract. Clinical and Experimental Ophthalmology, 36, 9, 852-860.
10.1111/j.1442-9071.2009.01925.x
2008 Edmonds, M., Graichen, F., Gardiner, J. & Abell, A. (2008). Enantioselective synthesis of α-fluorinated β²-amino acids. Organic Letters, 10, 5, 885-887.
10.1021/ol703045z
2007 Payne, R., Peyrot, F., Kerbarh, O., Abell, A. & Abell, C. (2007). Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors. ChemMedChem, 2, 7, 1015-1029.
10.1002/cmdc.200700032
2007 Paulik, M., Brooksby, P., Abell, A. & Downard, A. (2007). Grafting aryl diazonium cations to polycrystalline gold: Insights into film structure using gold oxide reduction redox probe electrochemistry and contact angle behavior. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces, 111, 21, 7808-7815.
10.1021/jp0706578
2007 Payne, R., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A., Lapthorn, A. & Abell, C. (2007). Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases. ChemMedChem, 2, 7, 1010-1013.
10.1002/cmdc.200700062
2007 Mathad, R., Jaun, B., Flogel, O., Gardiner, J., Loweneck, M., Codee, J. ... Abell, A. (2007). NMR-solution structures of fluoro-substituted β-peptides: A 3 14-helix and a hairpin turn. The first case of a 90° O=C-C-F dihedral angle in an a-fluoro-amide group. Helvetica Chimica Acta, 90, 12, 2251-2273.
10.1002/hlca.200790235
2007 Pearson, D., Downard, A., Muscroft-Taylor, A. & Abell, A. (2007). Reversible photoregulation of binding of α-chymotrypsin to a gold surface. Journal of the American Chemical Society, 129, 48, 14862-14863.
10.1021/ja0766674
2007 Zaman, S., Kitamura, M. & Abell, A. (2007). Synthesis of 5-phenyl 2-functionalized pyrroles by amino Heck and Tandem amino Heck carbonylation reactions. Australian Journal of Chemistry, 60, 8, 624-626.
10.1071/CH07132
2007 Abell, A., Jones, M., Neffe, A., Aitken, S., Cain, T., Payne, R. ... Morton, J. (2007). Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes: New anticataract agents. Journal of Medicinal Chemistry, 50, 12, 2916-2920.
10.1021/jm061455n
2007 McCarthy, A., Hartmann, R. & Abell, A. (2007). Evaluation of 4'-substituted bicyclic pyridones as non-steroidal inhibitors of steroid 5a-reductase. Bioorganic & Medicinal Chemistry Letters, 17, 13, 3603-3607.
10.1016/j.bmcl.2007.04.049
2006 Brooksby, P., Anderson, K., Downard, A. & Abell, A. (2006). Olefin Cross-Metathesis of Vinyl-Terminated Self-Assembled Monolayer (SAM) on Au(111): Electrochemical Study Using a Ferrocenyl Redox Center. Langmuir, 22, 22, 9304-9312.
10.1021/la062244o
2006 Abell, A. & Harvey, A. (2006). Synthesis of a [1,4]dioxane-2,5-dione based-peptidomimetic scaffold. ARKIVOC, 2006, 3, 72-76.
2006 Zaman, S., Campaner, P. & Abell, A. (2006). Synthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease. Bioorganic & Medicinal Chemistry, 14, 24, 8323-8331.
10.1016/j.bmc.2006.09.009
2006 McCarthy, A., Thomson, B., Shaw, I. & Abell, A. (2006). Estrogenicity of pyrethroid insecticide metabolites. Journal of Environmental Monitoring, 8, 1, 197-202.
10.1039/b511209e
2006 Pearson, D. & Abell, A. (2006). Photoswitch inhibitors of α-chymotrypsin-increased substitution and peptidic character in peptidomimetic boronate esters. Organic & Biomolecular Chemistry, 4, 19, 3618-3625.
10.1039/b609320p
2006 Gardiner, J., Aitken, S., McNabb, S., Zaman, S. & Abell, A. (2006). Ring closing metathesis of α- and β- amino acid derived dienes. Journal of Organometallic Chemistry, 691, 24-25, 5487-5496.
10.1016/j.jorganchem.2006.09.061
2006 Pearson, D. S., Alexander, N. A. & Abell, A. D. (2006). Light controlled switching of protease inhibition by peptidomimetics. JOURNAL OF PEPTIDE SCIENCE, 12, 167-167.
2005 Graichen, F., Giles, K., Abell, A. & Garrill, A. (2005). Removal of the nitro and phenyl groups from NPPB decreases its inhibitory effect on cytoplasmic streaming in the alga Nitella hookeri. Biochemistry and Cell Biology-Biochimie et Biologie Cellulaire, 83, 2, 133-139.
10.1139/O05-019
2005 Aitken, S. & Abell, A. (2005). Olefin metathesis: Catalyst development, microwave catalysis, and domino applications. Australian Journal of Chemistry, 58, 1, 3-13.
10.1071/CH04153
2005 Payne, R., Kerbarh, O., Miguel, R., Abell, A. & Abell, C. (2005). Inhibition studies on salicylate synthase. Organic & Biomolecular Chemistry, 3, 10, 1825-1827.
10.1039/b503800f
2005 Abell, A., Brown, K., Coxon, J., Jones, M., Miyamoto, S., Neffe, A. ... Stuart, B. (2005). Synthesis and evaluation of eight-membered cyclic pseudo-dipeptides. Peptides, 26, 2, 251-258.
10.1016/j.peptides.2004.09.006
2005 Neffe, A. & Abell, A. (2005). Developments in the design and synthesis of calpain inhibitors. Current Opinion in Drug Discovery & Development, 8, 6, 684-700.
2005 Payne, R., Bulloch, E., Abell, A. & Abell, C. (2005). Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic & Biomolecular Chemistry, 3, 20, 3629-3635.
10.1039/b510633h
2005 Zaman, S., Mitsuru, K. & Abell, A. (2005). Synthesis of Trisubstituted Imidazoles by Palladium-Catalyzed Cyclization of O-Pentafluorobenzoylamidoximes: Application to Amino Acid Mimetics with a C-Terminal Imidazole. Organic Letters, 7, 4, 609-611.
10.1021/ol047628p
2005 Payne, R., Toscano, M., Bulloch, E., Aoell, A. & Abell, C. (2005). Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic and Biomolecular Chemistry, 3, 12, 2271-2281.
10.1039/b503802b
2005 ABELL, A. (2005). Design, Synthesis and Evaluation of Peptidomimetic Inhibitors of Proteases. Peptide science : proceedings of the ... Japanese Peptide Symposium, 2004, 63-66.
2004 Le Sann, C. & Abell, A. (2004). Synthesis and Properties of a Mesylated ArgoGel Resin. Australian Journal of Chemistry, 57, 4, 355-358.
10.1071/CH03247
2004 Payne, R., Brown, K., Coxon, J., Morton, J., Lee, H. & Abell, A. (2004). Peptidic aldehydes based on α- and β-amino acids: synthesis, inhibition of m-calpain, and anti-cataract properties. Australian Journal of Chemistry, 57, 9, 877-884.
10.1071/CH04080
2004 Gardiner, J. & Abell, A. (2004). Synthesis and X-ray structure of functionalised proline mimics. Arkivoc (Online Ed), 2004, 10, 46-52.
10.3998/ark.5550190.0005.a06
2004 Le Sann, C., Gower, M. & Abell, A. (2004). Inhibitors of types I and II dehydroquinase. Mini - Reviews in Medicinal Chemistry, 4, 7, 747-756.
2004 Abell, A. & Vernall, A. (2004). CROSS-METATHESIS REACTIONS OF AMINO ACID-DERIVED COMPOUNDS. JOURNAL OF PEPTIDE SCIENCE, 10, 137-137.
2004 Daines, A. & Abell, A. (2004). The preparation of side chain functionalized analogues of coenzyme Q for protein conjugation studies. Organic & Biomolecular Chemistry, 2, 16, 2371-2375.
10.1039/b407659a
2004 Payne, R., Daines, A., Clark, B. & Abell, A. (2004). Synthesis and protein conjugation studies of vitamin K analogues. Bioorganic & Medicinal Chemistry, 12, 22, 5785-5791.
10.1016/j.bmc.2004.08.037
2004 Gardiner, J. & Abell, A. (2004). Synthesis and solid state conformation of phenylalanine mimetics constrained in a proline-like conformation. Organic & Biomolecular Chemistry, 2, 16, 2365-2370.
10.1039/B406450J
2004 Abell, A. D. (2004). Chemistry at the interface. AUSTRALIAN JOURNAL OF CHEMISTRY, 57, 9, 819-819.
10.1071/CH04180
2004 Gardiner, J., Anderson, K., Downard, A. & Abell, A. (2004). The synthesis of cyclic β-amino acid esters from Methionone, Allylglycine, and Serine. Journal of Organic Chemistry, 69, 10, 3375-3382.
10.1021/jo049794g
2004 Vernall, A. & Abell, A. (2004). Cross-metathesis coupling of sugars and fatty acids to lysine and cysteine. Organic & Biomolecular Chemistry, 2, 18, 2555-2557.
10.1039/b411770k
2004 Martyn, D. & Abell, A. (2004). The Synthesis and Testing of α-(Hydroxymethyl) pyrroles as DNA Binding Agents. Australian Journal of Chemistry, 57, 11, 1073-1077.
10.1071/CH04183
2004 Anderson, K., Gardiner, J. & Abell, A. (2004). FUNCTIONALISED beta-AMINO ACIDS. JOURNAL OF PEPTIDE SCIENCE, 10, 160-160.
2003 Humphries, M., Murphy, J., Phillips, A. & Abell, A. (2003). Synthesis of functionalized piperidinones. Journal of Organic Chemistry, 68, 6, 2432-2436.
10.1021/jo0267091
2003 Le Sann, C., Abell, C. & Abell, A. (2003). A Convenient Method for the Synthesis of Dehydroquinic Acid. Synthetic Communications, 33, 4, 527-533.
10.1081/SCC-120015805
2003 Gardiner, J. & Abell, A. (2003). A diastereoselective synthesis of the tetrahydropyridazinone core of 2-oxo-1,6-diazobicyclo[4.3.0]nonane-9-carboxylate-based peptidomimetics starting from (S)-phenylalanine. Tetrahedron Letters, 44, 22, 4227-4230.
10.1016/S0040-4039(03)00882-7
2003 Martyn, D., Vernall, A., Clark, B. & Abell, A. (2003). Ring-deactivated hydroxyalkylpyrrole-based inhibitors of alpha-chymotrypsin: synthesis and mechanism of action. Organic & Biomolecular Chemistry, 1, 12, 2103-2110.
10.1039/b302411c
2003 Vernall, A. & Abell, A. (2003). Cross metathesis of nitrogen-containing systems. Aldrichimica Acta, 36, 3, 93-105.
10.1002/chin.200450254
2003 Daines, A., Payne, R., Humphries, M. & Abell, A. (2003). The synthesis of naturally occurring vitamin K and vitamin K analogues. Current Organic Chemistry, 7, 16, 1625-1634.
10.2174/1385272033486279
2003 Giles, K., Humphries, M., Abell, A. & Garrill, A. (2003). The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K⁺ channels of the alga Nitella hookeri. Bioorganic & Medicinal Chemistry Letters, 13, 2, 293-295.
10.1016/S0960-894X(02)00920-4
2002 Payne, R. & Abell, A. (2002). Protein binding studies of vitamin K analogues for use in an immunological assay. Chemistry in New Zealand, 66, 1, 16-20.
2002 Le Sann, C., Abell, C. & Abell, A. (2002). A simple method for the preparation of 3-hydroxyiminodehydroquinate, a potent inhibitor of type II dehydroquinase. Journal of the Chemical Society. Perkin Transactions 1, 18, 18, 2065-2068.
10.1039/b206066c
2002 Abell, A. & Gardiner, J. (2002). Synthesis of substituted cyclohexenyl-based beta-amino acids by ring-closing metathesis. Organic Letters, 4, 21, 3663-3666.
10.1021/ol0266121
2002 Abell, A., Martyn, D., May, B. & Nabbs, B. (2002). An amino acid N-derivatising group that can be coloured on demand. Tetrahedron Letters, 43, 20, 3673-3675.
10.1016/S0040-4039(02)00625-1
2002 May, B. & Abell, A. (2002). α-Methylene tetrazole-based peptidomimetics: synthesis and inhibition of HIV protease. Journal of the Chemical Society. Perkin Transactions 1, 2, 2, 172-178.
10.1039/b109128j
2001 Zubarev, V., Trifonov, R., Filichev, V., Ostrovskii, V., Abell, A. & Edmonds, M. (2001). Synthesis, X-ray and conformational studies of novel tetrazole-containing macrocyles: 4,13-dioxa-1,7,8,9,17,18,19,20-octaazatricyclo[14.2.1⁷, ¹⁰]icosa-8,10(20),16(19),17-tetraene and 4,14-dioxa-1,7,8,9,10,18,19,20-octaazatricyclo[15.2.1.0⁷, ¹⁰]icosa-8. Journal of the Chemical Society. Perkin Transactions 2, 3, 3, 417-421.
10.1039/b006217k
2001 Abell, A. & Nabbs, B. (2001). Ring-deactivated hydroxymethylpyrroles as inhibitors of α-chymotrypsin. Bioorganic & Medicinal Chemistry, 9, 3, 621-628.
10.1016/S0968-0896(00)00274-1
2001 Harvey, A. & Abell, A. (2001). α-Ketoester-based photobiological switches: synthesis, peptide chain extension and assay against α-chymotrypsin. Bioorganic & Medicinal Chemistry Letters, 11, 18, 2441-2444.
10.1016/S0960-894X(01)00464-4
2001 May, B. & Abell, A. (2001). The synthesis and solid state structure of (8S)-8-benzyl-8,9-dihydro-7H-tetrazolo[1,5-d][1,4]diazepin-6-one. Chemical Communications, 20, 20, 2080-2081.
10.1039/b106175p
2001 Harvey, A. & Abell, A. (2001). Alpha-ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin.. Bioorganic & medicinal chemistry letters, 11, 18, 2441-2444.
10.1016/s0960-894x(01)00464-4
2001 Abell, A. (2001). Heterocyclic-based peptidomimetics. Letters in Peptide Science, 8, 3-5, 267-272.
10.1023/A:1016216828677
2001 May, B. & Abell, A. (2001). The synthesis and crystal structure of alpha-keto tetrazole-based dipeptide mimics. Tetrahedron Letters, 42, 33, 5641-5644.
10.1016/S0040-4039(01)01101-7
2001 Edmonds, M. & Abell, A. (2001). Design and synthesis of a conformationally restricted trans peptide isostere based on the bioactive conformations of saquinavir and nelfinavir. Journal of Organic Chemistry, 66, 11, 3747-3752.
10.1021/jo0016834
2001 Martyn, D., Hoult, D. & Abell, A. (2001). Stereocontrol of the Horner-Wadsworth-Emmons Reaction: Application to the Synthesis of HIV-1 Protease Inhibitors. Australian Journal of Chemistry, 54, 6, 391-396.
10.1071/CH01093
2001 Abell, A. & Gower, M. (2001). New Herbicidal and Antimicrobial Agents that Inhibit the Shikimate Pathway. New Zealand Science Review, 58, 3, 87-90.
2000 Gerrard, J., Prince, M. & Abell, A. (2000). Kinetic characterisation of ene-diol-based inhibitors of α-amylase. Bioorganic and Medicinal Chemistry Letters, 10, 14, 1575-1576.
10.1016/S0960-894X(00)00288-2
2000 Phillips, A., Morris, J. & Abell, A. (2000). Progress towards an intramolecular Diels-Alder ring-expansion approach to taxinine: The interplay of Lewis acids and high pressure. Tetrahedron Letters, 41, 15, 2723-2727.
10.1016/S0040-4039(00)00248-3
2000 Abell, A., Prince, M., McNulty, A. & Neubauer, B. (2000). Simple Bi- and tricyclic inhibitors of human steroid 5α-Reductase. Bioorganic and Medicinal Chemistry Letters, 10, 17, 1909-1911.
10.1016/S0960-894X(00)00368-1
1999 Abell, A., Oldham, M., Moore, M. & Robinson, W. (1999). The synthesis and X-ray crystal structure of phenylalanine-based N-benzyloxysuccinimides. Australian Journal of Chemistry, 52, 10, 977-981.
10.1071/CH99055
1999 Abell, A. & Oldham, M. (1999). Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis of all four stereoisomers and their assay against serine proteases. Bioorganic and Medicinal Chemistry Letters, 9, 3, 497-500.
10.1016/S0960-894X(99)00017-7
1999 Phillips, A. & Abell, A. (1999). Ring-closing metathesis of nitrogen-containing compounds: Applications to heterocycles, alkaloids, and peptidomimetics. Aldrichimica Acta, 32, 3, 75-88.
1999 Martyn, D., Moore, M. & Abell, A. (1999). Succinimide and saccharin-based enzyme-activated inhibitors of serine proteases. Current Pharmaceutical Design, 5, 6, 405-415.
1999 Abell, A., Nabbs, B., Battersby, A., Thompson, A. & Dolphin, D. (1999). Synthesis and properties of ring-deactivated Deuterated (hydroxymethyl)pyrroles. Chemtracts, 12, 7, 534-538.
1999 Nabbs, B. & Abell, A. (1999). The synthesis and P388 cytotoxicity of mycalazol 11 and related 5-acyl- 2-hydroxymethylpyrroles. Bioorganic and Medicinal Chemistry Letters, 9, 3, 505-508.
10.1016/S0960-894X(99)00021-9
1999 May, B. & Abell, A. (1999). A convenient preparation of (2SR,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid; an important peptide bond isostere. Synthetic Communications, 29, 14, 2515-2525.
10.1080/00397919908086259
1999 Abell, A. & Nabbs, B. (1999). Properties and reactions of ring-deactivated deuterated hydroxymethylpyrroles. Organic Letters, 1, 9, 1403-1405.
10.1021/ol990959v
1999 Abell, A. & Gardiner, J. (1999). Synthesis of lactam-based peptidomimetics from β-keto esters and β- keto amides. Journal of Organic Chemistry, 64, 26, 9668-9672.
10.1021/jo991306v
1998 Abell, A., Nabbs, B. & Battersby, A. (1998). Synthesis and properties of ring-deactivated deuterated (hydroxymethyl)pyrroles. Journal of the American Chemical Society, 120, 8, 1741-1746.
10.1021/ja973656+
1998 Abell, A., Nabbs, B. & Battersby, A. (1998). The reaction of N-magnesium derivatives of pyrroles with N- mesylchloromethylpyrroles: A synthesis of dipyrrylmethanes. Journal of Organic Chemistry, 63, 23, 8163-8169.
10.1021/jo980573i
1998 Abell, A., Litten, J. & Nabbs, B. (1998). H-1 NMR study of the hydrolysis of N-acylhydroxy[H-2]methylpyrroles. CHEMICAL COMMUNICATIONS, 8, 919-920.
10.1039/a801276h
1998 Abell, A., Ratcliffe, M. & Gerrard, J. (1998). Ascorbic acid-based inhibitors of α-amylases. Bioorganic and Medicinal Chemistry Letters, 8, 13, 1703-1706.
10.1016/S0960-894X(98)00298-4
1998 Abell, A., Gardiner, J., Phillips, A. & Robinson, W. (1998). Synthesis and X-ray structure of a 1,2,3,6-tetrahydropyridine-based phenylalanine mimetic. Tetrahedron Letters, 39, 51, 9563-9566.
10.1016/S0040-4039(98)02125-X
1998 Abell, A., Phillips, A., Budhia, S., McNulty, A. & Neubauer, B. (1998). The preparation and biological activity of lactam-based, non-steroidal, inhibitors of human type-1 steroid 5α-reductase. Australian Journal of Chemistry, 51, 5, 389-396.
10.1071/C97130
1998 Abell, A., Litten, J. & Nabbs, B. (1998). 1H NMR study of the hydrolysis of N-acylhydroxy[2H]methylpyrroles. Chemical Communications, 8, 919-920.
10.1039/a801276h
1997 Carr, A., Winterbourn, C., Blunt, J., Phillips, A. & Abell, A. (1997). Nuclear magnetic resonance characterization of 6α-chloro-5β- cholestane-3β,5-diol formed from the reaction of hypochlorous acid with cholesterol. Lipids, 32, 4, 363-367.
10.1007/s11745-997-0046-8
1997 Abell, A. D. & Oldham, M. D. (1997). Synthesis and X-ray crystallographic structure of leucine-phenylalanyl succinimide-based pseudopeptides. Journal of Organic Chemistry, 62, 5, 1509-1513.
10.1021/jo961781i
1997 Abell, A., Hoult, D., Bergman, D. & Fairlie, D. (1997). Simple cis-epoxide-based inhibitors of HIV-1 protease. Bioorganic and Medicinal Chemistry Letters, 7, 22, 2853-2856.
10.1016/S0960-894X(97)10106-8
1997 Abell, A., Edwards, R. & Oldham, M. (1997). Chemistry and X-ray crystallographic structure of N-protected (5-oxo-1,3-oxazolidin-4-yl)acetic acids: Versatile intermediates in the synthesis of peptidomimetics. Journal of the Chemical Society - Perkin Transactions 1, 11, 1655-1662.
10.1039/a608165g
1997 Abell, A. & Foulds, G. (1997). Synthesis of a cis-conformationally restricted peptide bond isostere and its application to the inhibition of the HIV-1 protease. Journal of the Chemical Society - Perkin Transactions 1, 17, 2475-2482.
10.1039/a702458d
1997 Abell, A., Brandt, M., Levy, M. & Holt, D. (1997). Preparation and biological activity of tricyclic non-steroidal inhibitors of human steroid 5α-reductase. Journal of the Chemical Society - Perkin Transactions 1, 11, 1663-1667.
10.1039/a608169j
1997 Abell, A., Blunt, J., Foulds, G. & Munro, M. (1997). Chemistry of the mycalamides: Antiviral and antitumour compounds from a New Zealand marine sponge. Part 6. The synthesis and testing of analogues of the C(7)-C(10) fragment. Journal of the Chemical Society - Perkin Transactions 1, 11, 1647-1654.
10.1039/a608168a
1996 Abell, A., Taylor, J. & Oldham, M. (1996). Self-addition products from the alkylation of amino acid-derived oxazolidinones: X-ray molecular structures of (2R,4S,1′S)-3-benzoyl-4-[benzoylamino(phenyl)methyl]-4-benzyl-2-phenyl-1, 3-oxazolidin-5-one, (2R,4S,1′S)- and (2R,4S,1′R)-3-benzoyl-4-[benzoylamino(phenyl)methyl]-4-isopropyl-2-phenyl- 1,3-oxazolidin-5-one. Journal of the Chemical Society - Perkin Transactions 1, 11, 1299-1304.
10.1039/p19960001299
1996 Abell, A., Brandt, M., Levy, M. & Holt, D. (1996). A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme. Bioorganic and Medicinal Chemistry Letters, 6, 4, 481-484.
10.1016/0960-894X(96)00054-6
1996 Abell, A., Brandt, M., Levy, M. & Holt, D. (1996). The preparation and evaluation of (+/-)-trans-1-diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro- phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductase. Bioorganic and Medicinal Chemistry Letters, 6, 7, 883-884.
10.1016/0960-894X(96)00136-9
1995 Abell, A. & Henderson, B. (1995). Steroidal and non-steroidal inhibitors of steroid 5α-reductase. Current Medicinal Chemistry, 2, 1, 583-597.
1995 Abell, A., Oldham, M. & Taylor, J. (1995). Synthesis of Cyclic Acylated Enamino Esters from Enol Lactones, 4-Keto Amides, and 5-Hydroxy Lactams. Journal of Organic Chemistry, 60, 5, 1214-1220.
10.1021/jo00110a026
1995 Holt, D., Yamashita, D., Konialian-Beck, A., Luengo, J., Abell, A., Bergsma, D. ... Levy, M. (1995). Benzophenone- and Indolecarboxylic Acids: Potent Type-2 Specific Inhibitors of Human Steroid 5α-Reductase. Journal of Medicinal Chemistry, 38, 1, 13-15.
10.1021/jm00001a004
1995 Abell, A., Oldham, M. & Taylor, J. (1995). Synthesis of phenylalanine-based cyclic acylated enamino ester dipeptide analogues: Inhibitors of α-chymotrypsin. X-ray molecular structure of (2′S,4′R)-4′-benzyl-3′-benzyloxycarbonyl-5′-oxo- 2′-phenyloxazolidin-4′-ylacetic acid. Journal of the Chemical Society, Perkin Transactions 1, 7, 953-961.
10.1039/p19950000953
1994 Abell, A., Hoult, D., Morris, K., Taylor, J. & Trent, J. (1994). Erratum: Halogenation of keto acid phosphoranes: Synthesis of halo enol lactones and haloallenes (Journal of Organic Chemistry (1993) 58, (1531)). Journal of Organic Chemistry, 59, 5, 1230-.
1994 Abell, A., Brandt, M., Levy, M. & Holt, D. (1994). A non-steroidal diene acid inhibitor of human type 2 stereoid 5α-reductase. Bioorganic and Medicinal Chemistry Letters, 4, 19, 2327-2330.
10.1016/0960-894X(94)85034-8
1994 Abell, A., Hoult, D., Morris, K., Taylor, J. & Trent, J. (1994). Additions and Corrections: Halogenation of Keto Acid Phosphoranes:Synthesis of Halo Enol Lactones and Haloallenes (J. Org. Chem. (1993) 58(6) (1531–1537)(10.1021/jo00058a039)). Journal of Organic Chemistry, 59, 5, 1230-.
10.1021/jo00084a055
1994 Abell, A., Erhard, K., Yen, H., Yamashita, D., Brandt, M., Mohammed, H. ... Holt, D. (1994). Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5α-reductases. Bioorganic and Medicinal Chemistry Letters, 4, 11, 1365-1368.
10.1016/S0960-894X(01)80363-2
1993 Abell, A., Hoult, D., Morris, K., Taylor, J. & Trent, J. (1993). Halogenation of Keto Acid Phosphoranes: Synthesis of Halo Enol Lactones and Haloallenes. Journal of Organic Chemistry, 58, 6, 1531-1537.
10.1021/jo00058a039
1993 Abell, A. & Litten, J. (1993). Synthesis and Amino Acid Chain Extension of 1-Acylated Hydroxymethylpyrroles. Australian Journal of Chemistry, 46, 10, 1473-1483.
10.1071/CH9931473
1993 Abell, A., Clark, B., Morris, K. & Taylor, J. (1993). Fast atom bombardment mass spectra of keto acid and keto ester phosphoranes. Organic Mass Spectrometry, 28, 1, 27-29.
10.1002/oms.1210280107
1993 Abell, A. & Taylor, J. (1993). Synthesis of Cyclic Acylated Enamino Ester Dipeptide Analogues via the Bromolactonization of a Keto Acid Phosphorane. Journal of Organic Chemistry, 58, 1, 14-15.
10.1021/jo00053a006
1992 Abell, A., Hoult, D. & Jamieson, E. (1992). Synthesis of 1,2-disubstituted pyrroles: A cis peptide bond surrogate. Tetrahedron Letters, 33, 39, 5831-5832.
10.1016/0040-4039(92)89043-C
1992 Abell, A. & Litten, J. (1992). Synthesis and hydrolysis of dipeptide isosteres containing a proline analogue with latent reactivity. Tetrahedron Letters, 33, 21, 3005-3008.
10.1016/S0040-4039(00)79584-0
1991 Abell, A., Hartshorn, M., Maclennan, M., Robinson, W. & Wright, G. (1991). Reactions of 1,4-Dimethyl-4-nitro-cyclohexa-2,5-dien-1-yl acetates with nitrogen dioxide; The formation of polynitro cyclohexenyl esters. Australian Journal of Chemistry, 44, 1, 43-51.
10.1071/CH9910043
1991 Abell, A., Trent, J. & Robinson, W. (1991). Carboxy to ketone dimeric and catemeric hydrogen bonding in a keto acid phosphorane: X-ray structure of 6-ethoxycarbonyl-5-oxo-6- (triphenylphosphoranylidene)hexanoic acid. Journal of the Chemical Society, Chemical Communications, 6, 362-363.
10.1039/C39910000362
1991 Abell, A., Trent, J. & Morris, K. (1991). Combined x-ray crystallographic and infrared and raman spectroscopic study of hydrogen bonding patterns in keto acid phosphoranes. Journal of the Chemical Society, Perkin Transactions 2, 7, 1077-1083.
10.1039/p29910001077
1990 Abell, A., Morris, K. & Litten, J. (1990). Synthesis and Deprotection of [l-(Ethoxycarbonyl)-4-[(diphenylmethoxy)carbonyl]-l-methyl-2-oxobutyl]-triphenylphosphonium Chloride: A Key Intermediate in the Wittig Reaction between a Cyclic Anhydride and a Stabilized Ylide. Journal of Organic Chemistry, 55, 18, 5217-5221.
10.1021/jo00305a013
1990 Abell, A., Morris, K. & McKee, V. (1990). A single-crystal x-ray analysis of a novel intramolecular hydrogen- bonded biphenyl phosphorane. Australian Journal of Chemistry, 43, 4, 765-771.
10.1071/CH9900765
1989 Abell, A., Hartshorn, M., Robinson, W., Grant Waller, A. & Wright, G. (1989). Reactions of 4-methyl-1-(l′-methylethyl)-4-nitrocyclohexa-2, 5-dien-1-yl acetates with nitrogen dioxide; Towards a mechanism for the formation of polynitro cyclohexenyl esters on reaction of p-cymene with nitrogen dioxide in acetic anhydride. Australian Journal of Chemistry, 42, 12, 2225-2242.
10.1071/CH9892225
1989 Abell, A., Clark, B. & Robinson, W. (1989). Structural investigations of phosphoranes. a single-crystal x-ray analysis of 1-ethoxycarbonyl-2-oxopropylidene-triphenylphosphorane. Australian Journal of Chemistry, 42, 7, 1161-1167.
10.1071/CH9891161
1989 Abell, A., Trent, J. & Whittington, B. (1989). Low Temperature Nuclear Magnetic Resonance Study of the Acylation of a Stabilized Ylide: C- vs O-Acylation. Journal of Organic Chemistry, 54, 11, 2762-2763.
10.1021/jo00272a060
1989 ABELL, A., TRENT, J. & LITTEN, J. (1989). THE DESIGN AND PREPARATION OF REACTIVE AMINO-ACID ANALOGS - A NEW APPROACH TO HIV PROTEASE INHIBITION. NEW ZEALAND MEDICAL JOURNAL, 102, 879, 592-592.
1989 Abell, A. & Trent, J. (1989). A novel bromo lactonization of acylated phosphoranes. A new route to bromo enol lactones. Journal of the Chemical Society, Chemical Communications, 7, 409-410.
10.1039/C39890000409
1988 Abell, A., Clark, B. & Robinson, W. (1988). A Mechanistic Study of the Wittig Reaction Between a Cyclic Anhydride and a Stabilized Phosphorane. Australian Journal of Chemistry, 41, 8, 1243-1249.
10.1071/CH9881243
1987 Schauder, J., Jendrezejewski, S., Abell, A., Hart, G. & Battersby, A. (1987). Stereochemistry of formation of the hydroxymethyl group of hydroxymethylbilane, the precursor of uro'gen-III. Journal of the Chemical Society, Chemical Communications, 6, 436-438.
10.1039/C39870000436
1985 Abell, A. D., Horn, E., Jones, G. P., Snow, M. R., Massywestropp, R. A. & Riccio, R. (1985). The structure of a stable serrulatane diterpenoid acetal from eremophila rotundifolia. Australian Journal of Chemistry, 38, 12, 1837-1845.
10.1071/CH9851837
1985 ABELL, A. & MASSYWESTROPP, R. (1985). EREMOPHILANE AND SERRULATANE TERPENOIDS FROM EREMOPHILA-ROTUNDIFOLIA. AUSTRALIAN JOURNAL OF CHEMISTRY, 38, 8, 1263-1269.
1985 ABELL, A. D., HEINICKE, G. W. & MASSYWESTROPP, R. A. (1985). SYNTHESIS OF DIALKYL HEX-2-YNE-1,6-DIOATES AND HEPT-2-YNE-1,7-DIOATES. SYNTHESIS-STUTTGART, 1985, 8, 764-766.
10.1055/s-1985-31339
1985 Abell, A. D., Massywestropp, R. A. & Reynolds, G. D. (1985). Rearrangement of freelingyne with base. Australian Journal of Chemistry, 38, 7, 1129-1131.
10.1071/CH9851129
1985 Abell, A. D. & Massywestropp, R. A. (1985). Regioselective bond cleavage and coordination effects in the reduction of some acetals with lithium in ammonia. Tetrahedron, 41, 12, 2451-2464.
10.1016/S0040-4020(01)96640-2
1985 Abell, A. D. & Massywestropp, R. A. (1985). Mechanism of acetal cleavage with methylmagnesium iodide. Australian Journal of Chemistry, 38, 7, 1031-1036.
10.1071/CH9851031
1984 Abell, A., Dimitriadis, E. & Massy, R. (1984). Stereospecific formation of tetrahydrofurans from substituted 2, 8-dioxabicyclo[3.2.1]oct-3-ylmethanols. Australian Journal of Chemistry, 37, 2, 395-407.
10.1071/CH9840395
1982 Abell, A., Doyle, I. & Massy-Westropp, R. (1982). The wittig reaction with glutaric and succinic anhydrides. Australian Journal of Chemistry, 35, 11, 2277-2287.
10.1071/CH9822277
1982 Abell, A. & Massy-Westropp, R. (1982). Aspects of the Mechanism of the Wittig Reaction Between Cyclic Anhydrides and Stabilized Phosphoranes. Australian Journal of Chemistry, 35, 10, 2077-2087.
10.1071/CH9822077

Book Chapters

Year Citation
2016 Hudson, I. L., Leemaqz, S. Y., Neffe, A. T. & Abell, A. D. (2016). Classifying calpain inhibitors for the treatment of cataracts: A self organising map (SOM) ANN/KM approach in drug discovery. In S. Shanmuganathan & S. Samarasinghe (Eds.), Artificial Neural Network Modelling (pp. 161-212). Switzerland: Springer.
10.1007/978-3-319-28495-8_9
2013 Abell, A. & Pehere, Ashok D., (2013). Macrocyclic Protease Inhibitors Constrained into a β-Strand Geometry. In S. Chakraborti & N. S. Dhalla (Eds.), Proteases in Health and Disease (pp. 181-192). Springer.
10.1007/978-1-4614-9233-7_11
2011 Pedersen, Daniel Sejer, & Abell, A. D. (2011). Huisgen cycloaddition in peptidomimetic chemistry. In Hughes, Andrew B (Ed.), Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis (pp. 99-127). Wiley.
10.1002/9783527631827.ch2
2009 Abell, A. D. & Edmonds, M. (2009). Synthesis using the Wittig and related Phosphorus-, Silicon-, or Sulfur-based reactions.. In V. H. Rawal (Ed.), Science of Synthesis Thieme Chemistry.
2004 Edmonds, M. & Abell, A. (2004). The Wittig Reaction. In Takeshi Takeda (Ed.), Modern Carbonyl Olefination: Methods and Applications (pp. 1-16). VCH: Wiley.
10.1002/3527601880.ch1
2004 Abell, A. & Edmonds, M. (2004). Wittig and related reactions. In P. J. Murphy (Ed.), Organophosphorus Reagents: A Practical Approach in Chemistry (pp. 99-126). Oxford: Oxford University Press.
1999 Abell, A. D. (1999). Advances in Peptidomimetics and amino acid mimics. In A. D. Abell (Ed.), Peptidomimetics and amino acid mimics JAI Press,.
1997 Abell, A. D. (1997). Advances in Peptidomimetics and amino acid mimics. In A. D. Abell (Ed.), Advances in Peptidomimetics and amino acid mimics JAI Press.
1997 Abell, A. D. (1997). Advances in Peptidomimetics and amino acid mimics. In A. D. Abell (Ed.), Advances in Peptidomimetics and amino acid mimics JAI Press.
1995 Abell, A. D. & Taylor, J. M. (1995). Trimethyl phosphonoacetate.. In L. A. Paquette (Ed.), Encyclopedia of Reagents for Organic Synthesis (pp. 5220-5223). John Wiley and Son.
1995 Abell, A. D. (1995). Triethyl phosphonoacetate.. In L. A. Paquette (Ed.), Encyclopedia of Reagents for Organic Synthesis (pp. 5116-5118). John Wiley and Son.
1995 Abell, A. D. & Taylor, J. M. (1995). Dimethyl bis(methylthio)methylphosphonate. In L. A. Paquette (Ed.), Encyclopedia of Reagents for Organic Synthesis (pp. 2031-2033). John Wiley and Son).
1995 Abell, A. D. (1995). Dimethyl methylphosphonate. In L. A. Paquette (Ed.), Encyclopedia of Reagents for Organic Synthesis (pp. 2098-2110). John Wiley and Son.
1991 Abell, A. D. (1991). Latent reactivity: The study of enzyme mechanisms and the design of enzyme inactivators. In J. M. Coxon (Ed.), Advances in Detailed Reaction Mechanisms (pp. 243-278). JAI Press,.

Conference Papers

Year Citation
2016 Peddie, V., Heng, S., Mustafa, S., Thomas, J., Hutchinson, M. & Abell, A. (2016). Shapeshifting photoswitchable azobenzene compounds and their biological applications. SPIE BioPhotonics Australasia Conference. M. Hutchinson & E. Goldys (Eds.) Adelaide, AUSTRALIA.
10.1117/12.2242356
2016 Purdey, M., Saini, A., McLennan, H., Pullen, B., Schartner, E., Sutton-McDowall, M. ... Abell, A. (2016). Biosensors for detecting stress in developing embryos. SPIE BioPhotonics Australasia Conference. M. Hutchinson & E. Goldys (Eds.) Adelaide, Australia.
10.1117/12.2244645
2016 Zhang, P., Ruan, S., Zhang, R., Pullen, B., Zhang, X., Purdey, M. ... Ruan, Y. (2016). Nitric oxide sensitive optic fiber sensor based on immobilized ruthenium(II) complex. Asia-Pacific Optical Sensors Conference, APOS 2016. Shanghai, China.
10.1364/APOS.2016.W3A.5
2016 Kumeria, T., Yu, J., Alsawat, M., Kurkuri, M., Santos, A., Abell, A. & Losic, D. (2016). Modulating molecular transport across peptide-modified nanoporous alumina membranes with light. SPIE BioPhotonics Australasia Conference. M. Hutchinson & E. Goldys (Eds.) Adelaide, Australia.
10.1117/12.2241495
2016 Sylvia, G., Heng, S. & Abell, A. (2016). Fluorescence enhancement of photoswitchable metal ion sensors. SPIE BioPhotonics Australasia Conference. M. Hutchinson & E. Goldys (Eds.) Adelaide, Australia.
10.1117/12.2244656
2015 da Costa, T. S., Tieu, W., Abell, A., Polyak, S. & Booker, G. (2015). "Humanised" biotin protein ligase provides clues about inhibitor selectivity. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life. Berlin, GERMANY.
2015 Purdey, M. S., Schartner, E. P., Sutton-McDowall, M. L., Ritter, L. J., Thompson, J. G., Monro, T. M. & Abell, A. D. (2015). Localised hydrogen peroxide sensing for reproductive health. SPIE Optics + Optoelectronics. F. Baldini, J. Homola & R. A. Lieberman (Eds.) Prague, Czech Republic.
10.1117/12.2178680
2014 Neffe, A., Chua, K., Luetzow, K., Pierce, B., Lendlein, A. & Abell, A. (2014). Crosslinking of gelatin by ring opening metathesis under aqueous conditions - an exploratory study. 12th International Polymers Advanced Technologies Conference (PAT 2013). A. Lendlein & M. Behl (Eds.) Belin, Germany.
10.1002/pat.3359
2014 Kostecki, R., Heng, S., Ebendorff-Heidepriem, H., Abell, A. D. & Monro, T. M. (2014). Functionalization of exposed core fibers with multiligand binding molecules for fluorescence based ion sensing. 23rd International Conference on Optical Fibre Sensors (OFS23). J. M. Lopez-Higuera, J. Jones, M. Lopez-Amo & J. L. Santos (Eds.) Santander, Spain.
10.1117/12.2059481
2013 Heng, S., Nguyen, M. C., Kostecki, R., Monro, T. & Abell, A. (2013). Nanoliter-scale, regenerable ion sensor: Sensing with surface functionalized microstructured optical fiber. Optical Sensors. Prague, Czech Republic.
10.1117/12.2016510
2013 Zafar, S., Cheema, S. A., Beh, E. J., Hudson, I. L., Hudson, S. A. & Abell, A. D. (2013). Linking ordinal log-linear models with Correspondence Analysis: an application to estimating drug-likeness in the drug discovery process. 20th International Congress on Modelling and Simulation (MODSIM). J. Piantadosi, R. S. Anderssen & J. Boland (Eds.) Adelaide, AUSTRALIA.
2009 Schartner, E., Pietsch, M., Abell, A. & Monro, T. (2009). A hydrogen peroxide fibre optic dip sensor for aqueous solutions. Australasian Conference on Optics, Lasers and Spectroscopy and Australian Conference on Optical Fibre Technology (ACOLS ACOFT). Adelaide.
2008 Schartner, E. P., Monro, T. M., Ebendorff-Heidepriem, H., Pietsch, M., Abell, A. D., Hulston, C. & Davis, C. (2008). Fuel degradation sensing using microstructured optical fibres.
2005 Vernall, A. J. & Abell, A. D. (2005). Cross-metathesis reactions of amino acids. 3rd International Peptide Symposium/28th European Peptide Symposium. M. Flegel, M. Fridkin, C. Gilon & J. Slaninova (Eds.) Prague, CZECH REPUBLIC.
2004 Anderson, K., Gardiner, J. & Abell, A. (2004). Conformationally constrained beta-amino acids. International Peptide Symposium & European Peptide Symposium. Prague, Czech Republic.
2003 Gower, M. A., Le Sann, C. & Abell, A. D. (2003). Synthesis of shikimate pathway inhibitors as potential antimicrobial agents.. 226th National Meeting of the American-Chemical-Society. NEW YORK, NEW YORK.
2003 Abell, A. (2003). Lectures presented at the 14th international conference on organic synthesis (ICOS-14), Christchurch, New Zealand, 14-18 July 2002: Preface.
2000 Harvey, A. & Abell, A. (2000). Azobenzene-containing, peptidyl α-ketoesters as photobiological switches of α-chymotrypsin.
10.1016/S0040-4020(00)00883-8

Conference Items

Year Citation
2015 Kostecki, R., Heng, S., Ebendorff-Heidepriem, H., Abell, A. & Monro, T. (2015). Thin-Film Polymer Functionalization of Optical Fiber Enabling Multiligand Chemosensing. 8th International Conference on Materials for Advanced Technologies & 4th Photonics Global Conference. Singapore.
2012 Keeling, K., Abell, A., Wegner, K., Booker, G., Scanlon, D. & Martin, L. (2012). Targeting protein-protein interactions using small peptides for treatment of disease.

Patents

Year Citation
2015 Wallace, J., Morona, R., Polyak, S., Booker, G., Abell, A. & Wilce, M.; (2015); Novel Antimicrobial Compounds;
2006 Abell, A., Neffe, A., Stuart, B., Lee, H., Morton, J., Coxon, J. ... Aitken, S.; (2006); Compounds and compositions;
2006 Abell, A., Neffe, A., Stuart, B., Lee, H., Morton, J., Coxon, J. ... Aitken, S.; (2006); Calpain inhibitors and compositions;
1995 Abell, A. D.; (1995); Diazo-phenanthrenone-based inhibitors of steroid 5-alpha reductase. Abell, A.D., Holt, D.A. International Application No. PCT/US95/04599, 1995.;

Major recent research grants and funding

  • 1993-1997:  PGSF funding, Synthetic and Natural Products as a Source of Pharmaceuticals ($910,000).
  • 1996-1998:  Three year funding in the inaugural round of the NZ Marsden fund ($59,000).
  • 1998:  The Agriculture and Marketing Research and Development Trust (AGMARDT) funding (PhD fellowship).
  • 1998:  Two year FORST postdoctoral funding ($140,000).
  • 1998:  Royal Society of Chemistry International Authors Travel Grant.
  • 1999-2002:  Chief Investigator A, Royal Society of NZ Marsden award.  Molecular Switches and the Modulation of Chemical Reactivity and Enzyme Action ($323,000).
  • 1999: University of Canterbury Research Grant, The Design and Synthesis of HIV Protease Inhibitors ($28,020).
  • 2001-2003: Chief Investigator A, Royal Society of NZ Marsden award. Design and Synthesis of Shikimate Pathway Inhibitors ($475,000).
  • 2002-2007: Chief Investigator A, FiRST grant. A medical treatment for Cataracts ($2 million over 5 years)
  • 2003-2005: Chief Investigator A, Royal Society of NZ Marsden award. Conformationally constrained and immobilised bioactives ($600,000).
  • 2004-2006: Chief Investigator B, Royal Society of NZ Marsden award. Behaviour, attachment and detachment of algal propagules in turbulent conditions ($700,000).
  • 2006 –2008: Chief Investigator A, Royal Society of NZ Marsden award. ‘To beta or not to beta that is the question’ ($850,000)

Relocated to the University of Adelaide (April 2007)

  • 2007 – 2009: Chief Investigator A, ARC Discovery grant DP077190. Mimicking peptide structure - towards an aqueous environment (A$300,000).
  • 2008 - 2009: Chief Investigator A, ARC International Fellowship grant LX0881950. Conformationally constrained and immobilized beta-peptides (A$119,000).
  • 2008 - 2010: Chief Investigator A, ARC Linkage International grant LX0881949. The synthesis and applications of aqueous metathesis. (A$38,000 over 3 years).
  • 2009: Chief Investigator, ARC Lief grant LE0989336. South Australian Facility for Small and Large Molecule X-ray Diffraction Structure Determination (A$560,000)
  • 2008 - 2009: Chief Investigator, Commercial Accelerator Scheme funding (A$250,000)
  • 2009 - 2010: Chief Investigator NHMRC development grant. Proof of concept studies on a novel antibiotic. (A$195,000).
  • 2009 – 2012: Chief Investigator A, ARC Discovery grant DP0985176. Electron transfer in proteins, a study of mechanism and function. (A$350,000).
  • 2010: Chief Investigator, Cancer Council SA.  Restoration of p53 activity in tumours: A new approach involving the p53 coactivator. (A$90,000).
  • 2010: Chief Investigator, Cancer Council SA. Antagonists of Gankyrin as anti-cancer agents. (A$84,000)
  • 2010: A lead academic for Australian Government HEEF funding to establish a centre for Photonics and Surface Science University of Adelaide (A$28.8 million).
  • 2010-2011: Chief Investigator, International Science Linkages (ISL). Finding new medicines for important infectious diseases. (A$198,581)
  • 2010-2013: Chief Investigator, ARC Super Science fellowship FS100100039. Disruptive approaches to biological sensing. (A$834,000)
  • 2011: Chief Investigator, ARC Lief LE110100169. UV-VIS-IR Spectroscopic Ellipsometers for Advanced Material and Device Characterisation. (A$300,000)
  • 2011: University of Queensland Business School Enterprize award to Calpain Therapeutics ($100,000)
  • 2011-2014: Chief Investigator, Cancer CRC PhD top up scholarship. Proteasomal inhibitors as anti-cancer agents. (A$30,000).
  • 2011-2014: Chief Investigator A. NHMRC Project grant APP1011806. Inhibitors of biotin protein ligase: A new class of antibiotic targetting Staphylococcus aureus. (A$585,000)
  • 2011-2015: Chief Investigator, ARC Linkage LP110200736. Nanosampling sensors for real‑time embryo monitoring (A$420,000)
  • 2012-2016: Chief Investigator A, ARC DP. Defining peptide structure and function: The shape of things to come (A$355,000).
  • 2013-2017: Chief Investigator A, ARC DP130101827. Advancing New Pharmaceuticals (A$360,000)
  • 2013: Chief Investigator A, ARC Lief LE130100168. Adelaide NMR Centre (A$1.250 million)
  • 2014-2017 Chief Investigator A. NHMRC Project grant APP106885. A new class of antibiotic (A$725,000)
  • 2014-2017 Chief Investigator. NHMRC Project grant APP106885. The mechanism of cataract and its prevention. (A$688,000)
  • 2014-2021: Chief Investigator, ARC CE140100003. ARC Centre of Excellence for Nanoscale BioPhotonics. (A$40,000,000)
  • 2016: University of Adelaide Beacon Research equipment grant ($100,000)

Please see our Group webpage: http://physsci.adelaide.edu.au/bomcl/

Please also see the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP): http://cnbp.org.au/

 

RESEARCH GROUP MEMBERS (LISTED PAST TO PRESENT UNDER EACH HEADING)

Postdoctoral Fellows

Bruce Clark

Dr Michael Edmonds

Dr Florian Graichen

Dr Mark Humphries

Dr Christine Le Sann

Dr Wilford Lie

Dr Shigeru Miyamoto

Dr Barbara Thompson

Dr Michael Edmonds

Dr Nathan Alexander

Dr Andrew Muscroft-Taylor

Dr Paula Brooksby

Dr Matt Jones

Dr Axel Neffe

Dr Stephen McNabb

Dr Shazia Zaman

Dr Markus Pietsch

Dr Daniel Sejer Pedersen

Dr James Gardiner

Dr Steven Ballet

Dr Steven Polyak

Dr Denis Scanlon

Dr Jingxian Yu

Dr Sabrina Heng

Dr William Tieu

Dr Ondrej Zvarec

Dr Ashok Pehere

Dr Nathan Stanley

Dr Kate Wegener

Dr Kelly Keeling

Dr John Horsley

Dr Malcolm Purdey

Dr Jenny Butler

Dr Niels Krogsgaard-Larsen

Dr Michelle Zhang

Dr Victoria Peddie

Dr Lina Geng

Dr. Amanpreet Chahal

Dr Borja Lopez

Dr Beatriz Blanco Rodríguez

 

Honours students

Emily Jamieson

Jane Taylor

Chris Litten

Alison Daines

Glenn Foulds

Andrew Harvey

Barnaby May

Blair Henderson

Deborah Hoult

James Murphy

Michael Moore

Brent Nabbs

Mark Oldham

Andy Phillips

Maureen Price (Ratcliff)

Elizabeth Reid

Wong

Karina Brown

James Gardiner

Seung-Joo Lee

Jenny Malmström

Derek Martyn

Richard Payne

Hayden Peacock

Matt Rosenberg

Kelly Smith

Andrea Vernall

Mary Gower

Anna McCarthy

Janna Nikkel

Jennifer Gadd

Emma Turner

Hayden Peacock

Blair Stuart

David Pearson

Kelly Anderson

Victoria Peddie

Joanna Duncan

Hongyuan Chen

Aimee Zhang

Seth Jones

Kim Mitchel

William Tieu

Kevin Kuan

Kelly Keeling

Jiage Feng

Daniel Stubing

Ross Tieman

Benjamin Keiller

Alexandra Marrone

Angie Jarrad

Malcolm Purdey

David Armstrong

Tim Engler

Xiaozhou (Michelle) Zhang

Sarah Clark

Vincent Donohue

Irene Willcocks

Yuan Qi Yeoh

Aniket Kulkarni

Stephen Kirby

Lauren Murray

Kathryn Palasis

 

Masters students/MPhil

Kathy Morris

Fiona Buchanan

Sangeeta Budia

Tim May

Tom Cain

Mutita Klanchantra

Tarek Millar

Rebecca Chao*

Stephen Tulip*

Kayla Downey

Aimee Horsfall

Nicholas Schumann

Joel Lee*

Padraig Fyfe

 

PhD students

John Trent

Jane Taylor

Chris Litten

Scott Bringans

Alison Daines

Glenn Foulds

Andrew Harvey

Barnaby May

Deborah Hoult

Michael Moore

Brent Nabbs

Mark Oldham

Andy Phillips

Maureen Price (Ratcliff)

Elizabeth Reid

Karina Brown

James Gardiner

Derek Martyn

Richard Payne*

Kelly Smith

Andrea Vernall

Mary Gower

Anna McCarthy

Barbara Thompson

Janna Nikkel

Nathan Alexander

Emma Turner

Kristian Giles

Shazia Zaman

Steve Aitken

Blair Stuart

Hannah Lee

David Pearson

Kelly Anderson

Victoria Peddie

Joanna Duncan

Hongyuan Chen

Seth Jones

William Tieu

Tatiana P. Soares da Costa

Sue Ping Lim

Krystle Chua

Limei Siew

Ashok Pehere

Kelly Keeling

Jade Cottam

Nathan Stanley

Jiage Feng

Alaknanda Adwal

Daniel Stubing

John Horsley

Justin Spence*

Henry Pepper*

Malcolm Purdey

Xiaozhou (Michelle) Zhang

Ashleigh Paparella

Georgina Sylvia

Kwang Jun Lee

Jiulia Satiaputra*

Chery Law

Hiu Lam*

Adrian Markwell-Heys*

Michelle Cuickshank*

Yuan Qi Yeoh

Henry Sanders*

Lauren Murray*

Aniket Kulkarni

Stephen Kirby

Kathryn Palasis

Aimee Horsfall

Pat Capon

Birgit Gaiser

Sophie Valembois

Stefania Sassnink*

* co-supervised

Board Memberships

Date Role Board name Institution name Country
2015 - ongoing University of Adelaide Academic Board University of Adelaide
2011 - ongoing Chief Scientific Advisor and co-founder of new company, Calpain Therapeutics
2011 - ongoing Australian Research Council (ARC) College of Experts
2006 - ongoing 6th European Union Funding Framework panel (Brussels)
2005 - ongoing Australasian representative to the advisory group of two PACIFICHEM symposia (Hawaii)
2005 - ongoing New Zealand (MoRST) sponsored delegation to the Riken Institute Japan
2005 - ongoing Governing Board of NZ Chemical Genetics consortium
2001 - ongoing International representative to the Australian National Health and Medical Research Council Program Grant Committee (Melbourne Australia)
2001 - ongoing Royal Society of New Zealand Marsden Physical Sciences and Engineering panel
2000 - ongoing New Zealand representative to the Australian Peptide Association
2000 - ongoing Australasian representative to the advisory group of two PACIFICHEM symposia (Hawaii)

Offices Held

Date Office Name Institution Country
2013 - 2014 Head of School of Chemistry and Physics The University of Adelaide Australia
Position
Professor
Phone
83135652
Fax
8313 4380
Campus
North Terrace
Building
Badger
Room Number
G 19
Org Unit
Chemistry

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