| 2025 |
Akter, J., Lee, J. H. Z., Whelan, F., De Voss, J. J., & Bell, S. G. (2025). Characterisation of the Cytochrome P450 Monooxygenase CYP116B46 from Tepidiphilus thermophilus as a Homogentisic Acid Generating Enzyme and its Conversion to a Peroxygenase. ChemBioChem, 13 pages.
DOI |
| 2024 |
Lee, J. H. Z., Bruning, J. B., & Bell, S. G. (2024). An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase**. Chemistry: A European Journal, 30(8), e202303335-1-e202303335-8.
DOI Scopus2 |
| 2024 |
Lee, J. H. Z., Coleman, T., Mclean, M. A., Podgorski, M. N., Hayball, E. F., Stone, I. S. J., . . . Bell, S. G. (2024). Selective α-Hydroxyketone Formation and Subsequent C-C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes. ACS Catalysis, 14(11), 8958-8971.
DOI Scopus2 |
| 2023 |
Miller, J. C., Lee, J. H. Z., Mclean, M. A., Chao, R. R., Stone, I. S. J., Pukala, T. L., . . . Bell, S. G. (2023). Engineering C–C Bond Cleavage Activity into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society, 145(16), 9207-9222.
DOI Scopus13 WoS2 Europe PMC4 |
| 2023 |
Akter, J., Stockdale, T. P., Child, S. A., Lee, J. H. Z., De Voss, J. J., & Bell, S. G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244, 1-9.
DOI Scopus10 WoS3 |
| 2023 |
Podgorski, M. N., Lee, J. H. Z., Harbort, J. S., Nguyen, G. T. H., Doherty, D. Z., Donald, W. A., . . . Bell, S. G. (2023). Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant. Journal of Inorganic Biochemistry, 249, 1-13.
DOI Scopus1 |
| 2022 |
Coleman, T., Kirk, A. M., Lee, J. H. Z., Doherty, D. Z., Bruning, J. B., Krenske, E. H., . . . Bell, S. G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12(2), 1258-1267.
DOI Scopus21 WoS11 |
| 2022 |
Podgorski, M. N., Harbort, J. S., Lee, J. H. Z., Nguyen, G. T. H., Bruning, J. B., Donald, W. A., . . . Bell, S. G. (2022). An altered heme environment in an engineered cytochrome P450 enzyme enables the switch from monooxygenase to peroxygenase activity. ACS Catalysis, 12(3), 1614-1625.
DOI Scopus36 WoS17 |
| 2022 |
Lee, J., Podgorski, M., Moir, M., Gee, A. R., & Bell, S. G. (2022). Selective oxidations using a cytochrome P450 enzyme variant driven with surrogate oxygen donors and light. Chemistry: A European Journal, 28(49), 1-9.
DOI Scopus12 WoS7 Europe PMC2 |
| 2022 |
Coleman, T., Lee, J., Kirk, A. M., Doherty, D. Z., Podgorski, M. N., Pinidiya, D. K., . . . Bell, S. G. (2022). Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering. Chemistry: A European Journal, 28(67), 1-13.
DOI Scopus14 WoS2 Europe PMC3 |
| 2022 |
Coleman, T., Doherty, D. Z., Zhang, T., Podgorski, M. N., Qiao, R., Lee, J. H. Z., . . . Bell, S. G. (2022). Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation. Chemistry: An Asian Journal, 17(24), 1-15.
DOI Scopus9 WoS4 Europe PMC2 |
| 2021 |
Chao, R., Lau, I., Coleman, T., Churchman, L. R., Child, S. A., Lee, J. H. Z., . . . Bell, S. G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry: A European Journal, 27(59), 14765-14777.
DOI Scopus9 WoS6 Europe PMC2 |
| 2019 |
Day, A. J., Lee, J. H. Z., Phan, Q. D., Lam, H. C., Ametovski, A., Sumby, C. J., . . . George, J. H. (2019). Biomimetic and biocatalytic synthesis of bruceol. Angewandte Chemie - International Edition, 58(5), 1427-1431.
DOI Scopus15 WoS10 Europe PMC3 |
| 2019 |
Lee, J. H. Z., Wong, S. H., Stok, J. E., Bagster, S. A., Beckett, J., Clegg, J. K., . . . Bell, S. G. (2019). Selective hydroxylation of 1,8- and 1,4-cineole using bacterial P450 variants. Archives of Biochemistry and Biophysics, 663, 54-63.
DOI Scopus11 WoS8 Europe PMC4 |
| 2018 |
Dezvarei, S., Lee, J., & Bell, S. (2018). Stereoselective hydroxylation of isophorone by variants of the cytochromes P450 CYP102A1 and CYP101A1. Enzyme and Microbial Technology, 111, 29-37.
DOI Scopus17 WoS14 Europe PMC7 |
| 2017 |
Sarkar, M., Lee, J., & Bell, S. (2017). The oxidation of hydrophobic aromatic substrates by using a variant of the P450 monooxygenase CYP101B1. ChemBioChem, 18(21), 2119-2128.
DOI Scopus14 WoS13 Europe PMC6 |
| 2016 |
Hall, E., Sarkar, M., Lee, J., Munday, S., & Bell, S. (2016). Improving the monooxygenase activity and the regio- and stereoselectivity of terpenoid hydroxylation using ester directing groups. ACS Catalysis, 6(9), 6306-6317.
DOI Scopus37 WoS31 |
