Dr Tatiana Soares da Costa

• Appointments

  Date	Position	Institution name
  2024 - ongoing	Group Leader and ARC Future Fellow	University of Adelaide
  2022 - 2024	Group Leader and Future Making Fellow	University of Adelaide
  2019 - 2022	Group Leader and ARC DECRA Fellow	La Trobe University
  2015 - 2019	NHMRC Early Career Peter Doherty Fellow	La Trobe University
  2013 - 2015	Teaching Only Lecturer	Charles Sturt University

• Language Competencies

  Language	Competency
  Portuguese	Can read, write, speak and understand spoken

• Education

  Date	Institution name	Country	Title
  	The University of Adelaide	Australia	PhD
  	University of Canterbury	New Zealand	Master of Science (First Class Honours)
  	University of Canterbury	New Zealand	Bachelor of Science

• Journals

  Year	Citation
  2025	Mackie, E. R. R., Mckay, M. V., Barrow, A. S., & da Costa, T. P. S. (2025). Inhibitors of lysine biosynthesis enzymes as potential new herbicides. FUNCTIONAL PLANT BIOLOGY, 52(5), 13 pages. DOI
  2023	Javorsky, A., Maddumage, J. C., Mackie, E. R. R., Soares da Costa, T. P., Humbert, P. O., & Kvansakul, M. (2023). Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM. The FEBS journal, 290(4), 974-987. DOI Scopus9 Europe PMC9
  2023	Vujcic, B., Wyllie, J., Tania., Burns, J., White, K. F., Cromwell, S., . . . Houston, S. D. (2023). Cage Hydrocarbons as Linkers in Dimeric Drug Design: Case Studies with Trimethoprim and Tedizolid. Bioorganic and Medicinal Chemistry Letters, 80, 129086-1-129086-5. DOI Scopus3 WoS2
  2023	Ottonello, A., Wyllie, J. A., Yahiaoui, O., Sun, S., Koelln, R. A., Homer, J. A., . . . Moses, J. E. (2023). Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.. Proceedings of the National Academy of Sciences of the United States of America, 120(15), e2208737120. DOI Scopus12 WoS1 Europe PMC8
  2023	Mackie, E. R. R., Barrow, A. S., Giel, M. -C., Hulett, M. D., Gendall, A. R., Panjikar, S., & Soares da Costa, T. P. (2023). Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity. Communications Biology, 6(1), 1-11. DOI Scopus2 Europe PMC3
  2023	Christoff, R. M., Al Bayer, M., Soares da Costa, T. P., Perugini, M. A., & Abbott, B. M. (2023). Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds. RSC Medicinal Chemistry, 14(9), 1698-1703. DOI Scopus1
  2022	Soares da Costa, T., Wyllie, J., Ghardi, C., Hulett, M., Abbott, B., Sutton, M., & Perugini, M. (2022). The First Inhibitor of <i>Meso</i>-Diaminopimelate Biosynthesis with Antibacterial Activity Against Multi-Drug Resistant Bacteria. DOI
  2022	Mackie, E. R. R., Barrow, A. S., Christoff, R. M., Abbott, B. M., Gendall, A. R., & Soares da Costa, T. P. (2022). A dual-target herbicidal inhibitor of lysine biosynthesis. eLife, 11, 1-11. DOI Scopus6 WoS4 Europe PMC5
  2022	Wyllie, J. A., McKay, M. V., Barrow, A. S., & Soares da Costa, T. P. (2022). Biosynthesis of uridine diphosphate N-Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?. IUBMB life, 71(12), 1232-1252. DOI Scopus12 WoS5 Europe PMC8
  2022	Mather, J. C., Wyllie, J. A., Hamilton, A., Soares da Costa, T. P., & Barnard, P. J. (2022). Antibacterial silver and gold complexes of imidazole and 1,2,4-triazole derived N-heterocyclic carbenes. Dalton Transactions, 51(32), 12056-12070. DOI Scopus21 WoS4 Europe PMC7
  2022	Teakel, S., Marama, M., Aragao, D., Tsimbalyuk, S., Mackie, E. R. R., da Costa, T. P. S., . . . Cahill, M. A. (2022). Structural characterisation of a MAPR-related archaeal cytochrome b(5M) protein. FEBS Letters, 596(18), 2409-2417. DOI Scopus3 WoS2 Europe PMC2
  2021	Christoff, R. M., Soares da Costa, T. P., Bayat, S., Holien, J. K., Perugini, M. A., & Abbott, B. M. (2021). Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase. Bioorganic and Medicinal Chemistry, 52, 116518-1-116518-9. DOI Scopus6 WoS4 Europe PMC5
  2021	Wines, B. D., Trist, H. M., Esparon, S., Impey, R. E., Mackay, G. A., Andrews, R. K., . . . Hogarth, P. M. (2021). Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2. Frontiers in Immunology, 12, 666813-1-666813-13. DOI Scopus2 WoS1 Europe PMC3
  2021	Nonis, S. G., Haywood, J., Schmidberger, J. W., Mackie, E. R. R., Soares da Costa, T. P., Bond, C. S., & Mylne, J. S. (2021). Structural and biochemical analyses of concanavalin A circular permutation by jack bean asparaginyl endopeptidase. Plant Cell, 33(8), 2794-2811. DOI Scopus19 WoS7 Europe PMC12
  2021	Soares da Costa, T. P., Hall, C. J., Panjikar, S., Wyllie, J. A., Christoff, R. M., Bayat, S., . . . Perugini, M. A. (2021). Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants. eLife, 10, 1-17. DOI Scopus14 WoS11 Europe PMC10
  2021	Hall, C. J., Lee, M., Boarder, M. P., Mangion, A. M., Gendall, A. R., Panjikar, S., . . . Soares da Costa, T. P. (2021). Differential lysine-mediated allosteric regulation of plant dihydrodipicolinate synthase isoforms. FEBS Journal, 288(16), 4973-4986. DOI Scopus6 WoS5 Europe PMC4
  2020	Li, Z., MacKie, E. R. R., Ramkissoon, P., Mather, J. C., Wiratpruk, N., Soares Da Costa, T. P., & Barnard, P. J. (2020). Synthesis, conformational analysis and antibacterial activity of Au(I)-Ag(I) and Au(I)-Hg(II) heterobimetallic N-heterocyclic carbene complexes. Dalton Transactions, 49(36), 12820-12834. DOI Scopus12 WoS6 Europe PMC4
  2020	Impey, R. E., Hawkins, D. A., Sutton, J. M., & Soares da Costa, T. P. (2020). Overcoming intrinsic and acquired resistance mechanisms associated with the cell wall of gram-negative bacteria. Antibiotics, 9(9), 1-19. DOI Scopus62 WoS32 Europe PMC36
  2020	Suraweera, C. D., Anasir, M. I., Chugh, S., Javorsky, A., Impey, R. E., Hasan Zadeh, M., . . . Kvansakul, M. (2020). Structural insight into tanapoxvirus-mediated inhibition of apoptosis. FEBS Journal, 287(17), 3733-3750. DOI Scopus12 WoS8 Europe PMC9
  2020	Impey, R. E., Lee, M., Hawkins, D. A., Sutton, J. M., Panjikar, S., Perugini, M. A., & Soares da Costa, T. P. (2020). Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens. FEBS Letters, 594(9), 1453-1463. DOI Scopus4 WoS4 Europe PMC3
  2020	Young, N. D., Harris, T. J., Evangelista, M., Tran, S., Wouters, M. A., Soares da Costa, T. P., . . . Fairlie, W. D. (2020). Diversity in the intrinsic apoptosis pathway of nematodes. Communications Biology, 3(1), 478-1-478-12. DOI Scopus5 WoS3 Europe PMC3
  2020	Bleackley, M. R., Vasa, S., Harvey, P. J., Shafee, T. M. A., Kerenga, B. K., Soares da Costa, T. P., . . . Anderson, M. A. (2020). Histidine-rich defensins from the solanaceae and brasicaceae are antifungal and metal binding proteins. Journal of Fungi, 6(3), 1-14. DOI Scopus10 WoS4 Europe PMC8
  2020	Hall, C. J., Mackie, E. R. R., Gendall, A. R., Perugini, M. A., & Soares da Costa, T. P. (2020). Review: amino acid biosynthesis as a target for herbicide development. Pest Management Science, 76(12), 3896-3904. DOI Scopus20 WoS13 Europe PMC14
  2020	Giel, M. C., Smedley, C. J., Mackie, E. R. R., Guo, T., Dong, J., Soares da Costa, T. P., & Moses, J. E. (2020). Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides. Angewandte Chemie - International Edition, 59(3), 1181-1186. DOI Scopus72 WoS53 Europe PMC16
  2020	Impey, R. E., Panjikar, S., Hall, C. J., Bock, L. J., Sutton, J. M., Perugini, M. A., & Soares da Costa, T. P. (2020). Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation. The Federation of European Biochemical Societies (FEBS) Journal, 287(2), 386-400. DOI Scopus13 WoS11 Europe PMC11
  2020	Suraweera, C. D., Anasir, M. I., Chugh, S., Javorsky, A., Impey, R. E., Zadeh, M. H., . . . Kvansakul, M. (2020). Structural insight into tanapoxvirus mediated inhibition of apoptosis. DOI
  2019	Gilson, P. R., Kumarasingha, R., Thompson, J., Zhang, X., Penington, J. S., Kalhor, R., . . . Abbott, B. M. (2019). A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4. Scientific Reports, 9(1), 1-15. DOI Scopus20 WoS14 Europe PMC16
  2019	Lee, E. F., Smith, N. A., Soares da Costa, T. P., Meftahi, N., Yao, S., Harris, T. J., . . . Fairlie, W. D. (2019). Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1. Autophagy, 15(5), 785-795. DOI Scopus38 WoS30 Europe PMC30
  2019	Christoff, R. M., Gardhi, C. K., Soares Da Costa, T. P., Perugini, M. A., & Abbott, B. M. (2019). Pursuing DHDPS: An enzyme of unrealised potential as a novel antibacterial target. MedChemComm, 10(9), 1581-1588. DOI Scopus8 WoS8
  2018	Gupta, R., Hogan, C. J., Perugini, M. A., & Soares da Costa, T. P. (2018). Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum. Planta, 248(2), 381-391. DOI Scopus5 WoS4 Europe PMC3
  2018	Soares da Costa, T. P., Abbott, B. M., Gendall, A. R., Panjikar, S., & Perugini, M. A. (2018). Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis. Biophysical Reviews, 10(2), 153-162. DOI Scopus15 Europe PMC9
  2018	North, R. A., Wahlgren, W. Y., Remus, D. M., Scalise, M., Kessans, S. A., Dunevall, E., . . . Dobson, R. C. J. (2018). The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity. Frontiers in Chemistry, 6, 233-1-233-11. DOI Europe PMC18
  2018	Smith, K. M., Tsimbalyuk, S., Edwards, M. R., Cross, E. M., Batra, J., Soares da Costa, T. P., . . . Forwood, J. K. (2018). Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nature Communications, 9(1), 1-13. DOI Scopus54 WoS42 Europe PMC46
  2018	Stifter, S. A., Matthews, A. Y., Mangan, N. E., Fung, K. Y., Drew, A., Tate, M. D., . . . Hertzog, P. J. (2018). Defining the distinct, intrinsic properties of the novel type i interferon, IFNϵ. Journal of Biological Chemistry, 293(9), 3168-3179. DOI Scopus32 WoS23 Europe PMC27
  2018	Gupta, R., Soares da Costa, T. P., Faou, P., Dogovski, C., & Perugini, M. A. (2018). Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae. Protein Expression and Purification, 145, 85-93. DOI Scopus11 WoS11 Europe PMC7
  2018	Hall, C. J., & Soares da Costa, T. P. (2018). Lysine: biosynthesis, catabolism and roles. WikiJournal of Science, 1(1). DOI Scopus10
  2017	Ellisdon, A. M., Nold-Petry, C. A., D’Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., . . . Nold, M. F. (2017). Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Science Immunology, 2(8), 1-12. DOI Scopus53 WoS40 Europe PMC34
  2017	Soares da Costa, T. P., Patel, M., Desbois, S., Gupta, R., Faou, P., & Perugini, M. A. (2017). Identification of a dimeric KDG aldolase from Agrobacterium tumefaciens. Proteins: Structure, Function and Bioinformatics, 85(11), 2058-2065. DOI Scopus7 WoS6 Europe PMC5
  2017	Soares Da Costa, T. P., Nanson, J. D., & Forwood, J. K. (2017). Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes. Scientific Reports, 7(1), 1-9. DOI Scopus7 WoS5 Europe PMC4
  2016	Miles, N. G., & Soares da Costa, T. P. (2016). Acceptance of clickers in a large multimodal biochemistry class as determined by student evaluations of teaching: Are they just an annoying distraction for distance students?. Biochemistry and Molecular Biology Education, 44(1), 99-108. DOI Scopus7 WoS4 Europe PMC2
  2016	Christensen, J. B., Soares Da Costa, T. P., Faou, P., Pearce, F. G., Panjikar, S., & Perugini, M. A. (2016). Structure and Function of Cyanobacterial DHDPS and DHDPR. Scientific Reports, 6(1), 12 pages. DOI Scopus22 WoS16 Europe PMC16
  2016	Peverelli, M. G., Soares da Costa, T., Kirby, N., & Perugini, M. A. (2016). Dimerization of bacterial diaminopimelate decarboxylase is essential for catalysis. Journal of Biological Chemistry, 291(18), 9785-9795. DOI Scopus33 WoS27 Europe PMC23
  2016	da Costa, T. P. S. (2016). Conference survival guide-the dos and don'ts. CELL DEATH DISCOVERY, 2(1), 3 pages. DOI Europe PMC1
  2016	Soares da Costa, T. P., Desbois, S., Dogovski, C., Gorman, M. A., Ketaren, N. E., Paxman, J. J., . . . Perugini, M. A. (2016). Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target. Structure, 24(8), 1282-1291. DOI Scopus31 WoS26 Europe PMC23
  2016	Soares da Costa, T. P. (2016). Supervisor types: which one is your match?. Cell Death Discovery, 2(1), 2 pages. DOI Scopus2
  2015	Tieu, W., Polyak, S., Paparella, A., Yap, M., Soares Da Costa, T., Ng, B., . . . Abell, A. (2015). Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery. ACS Medicinal Chemistry Letters, 6(2), 216-220. DOI Scopus18 WoS17 Europe PMC9
  2014	Tieu, W., Jarrad, A. M., Paparella, A. S., Keeling, K. A., Soares da Costa, T. P., Wallace, J. C., . . . Abell, A. D. (2014). Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase. Bioorganic & Medicinal Chemistry Letters, 24(19), 4689-4693. DOI Scopus20 WoS17 Europe PMC8
  2014	Paparella, A., Soares Da Costa, T., Yap, M., Tieu, W., Wilce, M., Booker, G., . . . Polyak, S. (2014). Structure guided design of biotin protein ligase inhibitors for antibiotic discovery. Current Topics in Medicinal Chemistry, 14(1), 4-20. DOI Scopus27 WoS25 Europe PMC13
  2014	Soares da Costa, T., Yap, M., Perugini, M., Wallace, J., Abell, A., Wilce, M., . . . Booker, G. (2014). Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus. Molecular Microbiology, 91(1), 110-120. DOI Scopus21 WoS17 Europe PMC13
  2013	Tieu, W., Soares da Costa, T., Yap, M., Keeling, K., Wilce, M., Wallace, J., . . . Abell, A. (2013). Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitors. Chemical Science, 4(9), 3533-3537. DOI Scopus38 WoS34
  2012	Soares da Costa, T., Tieu, W., Yap, M., Zvarec, O., Bell, J., Turnidge, J., . . . Polyak, S. (2012). Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase. ACS Medicinal Chemistry Letters, 3(6), 509-514. DOI Scopus41 WoS36 Europe PMC21
  2012	Soares da Costa, T., Tieu, W., Yap, M., Pendini, N., Polyak, S., Pedersen, D., . . . Abell, A. (2012). Selective inhibition of biotin protein ligase from Staphylococcus aureus. Journal of Biological Chemistry, 287(21), 17823-17832. DOI Scopus60 WoS45 Europe PMC35
  2012	Mayende, L., Swift, R., Bailey, L., Soares da Costa, T., Wallace, J., Booker, G., & Polyak, S. (2012). A novel molecular mechanism to explain biotin-unresponsive holocarboxylase synthetase deficiency. Journal of Molecular Medicine-JMM, 90(1), 81-88. DOI Scopus27 WoS23 Europe PMC19
  2010	Soares da Costa, T. P., Muscroft-Taylor, A. C., Dobson, R. C. J., Devenish, S. R. A., Jameson, G. B., & Gerrard, J. A. (2010). How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?. Biochimie, 92(7), 837-845. DOI Scopus32 WoS29 Europe PMC21
  2010	Muscroft-Taylor, A. C., Soares da Costa, T. P., & Gerrard, J. A. (2010). New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry. Biochimie, 92(3), 254-262. DOI Scopus24 WoS19 Europe PMC13

• Book Chapters

  Year	Citation
  2020	Gaskin, S. M., Soares Da Costa, T. P., & Hulett, M. D. (2020). Heparanase: Cloning, Function and Regulation. In Advances in Experimental Medicine and Biology (Vol. 1221, pp. 189-229). Springer International Publishing. DOI Scopus9 WoS8 Europe PMC9
  2015	Soares Da Costa, T. P., Christensen, J. B., Desbois, S., Gordon, S. E., Gupta, R., Hogan, C. J., . . . Perugini, M. A. (2015). Quaternary Structure Analyses of an Essential Oligomeric Enzyme. In J. L. Cole (Ed.), Methods in Enzymology (Vol. 562, pp. 205-223). ELSEVIER ACADEMIC PRESS INC. DOI Scopus20 WoS16 Europe PMC15

• Preprint

  Year	Citation
  2022	Antoney, J., Kainrath, S., Ahmed, F. H., Kang, S. W., Mackie, E. R. R., Soares da Costa, T. P., . . . Janovjak, H. (2022). A F<sub>420</sub>-dependent single domain chemogenetic tool for protein de-dimerization. DOI
  2022	Mackie, E. R. R., Barrow, A. S., Christoff, R. M., Abbott, B. M., Gendall, A. R., & Soares da Costa, T. P. (2022). A dual-target herbicidal inhibitor of lysine biosynthesis. DOI

2022–2024: Honours Coordinator, School of Agriculture, Food and Wine

• Current Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2025	Principal Supervisor	Structural and functional characterisation of protein targets to guide the design of novel herbicides	Master of Philosophy	Master	Full Time	Chaudhry Artemiy Hussnain
  2025	Principal Supervisor	Integration of Experimental Approaches for Exploration and Development of Novel Antifungal Agents: Addressing Emerging Resistance Challenges	Doctor of Philosophy	Doctorate	Full Time	Miss Olivia Pei Ying Oh
  2024	Co-Supervisor	Preclinical evaluation of new derivatives of the anticoccidial drug robenidine as novel antibacterial agents	Doctor of Philosophy	Doctorate	Full Time	Ms Sayara Bista
  2024	Co-Supervisor	Identify and characterise plant glycosyltransferases involved in critical components of cell wall biosynthesis: identifying essential building blocks for efficient bioenergy production.	Doctor of Philosophy	Doctorate	Full Time	Miss Xingyi Zhou
  2023	Principal Supervisor	Unlocking the Value of Lysine for Sustainable Agriculture	Doctor of Philosophy	Doctorate	Full Time	Miss Mirrin McKay
  2022	Principal Supervisor	Developing novel strategies to monitor and combat herbicide resistance	Doctor of Philosophy	Doctorate	Full Time	Ms Sreshtha Malik
  2022	Principal Supervisor	A novel repurposing approach for herbicide discovery to combat resistant weeds	Doctor of Philosophy	Doctorate	Full Time	Mr Ryan James Francis McClean

• Past Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2022 - 2023	Principal Supervisor	Strategies to Circumvent Herbicide Resistance Through the Inhibition of Lysine Biosynthesis	Doctor of Philosophy	Doctorate	Full Time	Dr Emily Rose Ronayne Mackie
  2022 - 2024	Principal Supervisor	Exploring Alternative Strategies in Antibiotic Discovery to Tackle Multidrug-Resistant Bacteria	Doctor of Philosophy	Doctorate	Full Time	Miss Jessica Anne Wyllie
  2022 - 2025	Principal Supervisor	Investigating Novel Antibiotic and Herbicide Targets to Circumvent Resistance	Doctor of Philosophy	Doctorate	Part Time	Mr Daniel Adam Hawkins

• Board Memberships

  Date	Role	Board name	Institution name	Country
  2020 - ongoing	Board Member	Board of Directors	Science & Technology Australia	Australia
  2019 - ongoing	Member	Executive Committee	Australian Society for Biochemistry and Molecular Biology	Australia

• Editorial Boards

  Date	Role	Editorial Board Name	Institution	Country
  2016 - ongoing	Editor	Editor	Australian Biochemist Magazine	Australia

• Position: Group Leader and ARC Future Fellow
• Phone: 83131069
• Email: tatiana.soaresdacosta@adelaide.edu.au
• Campus: Waite
• Building: Plant Genomics Centre, floor Level Two
• Room: 2.34
• Org Unit: Waite Research Institute