Dr Tatiana Soares da Costa
Senior Lecturer
School of Agriculture, Food and Wine
College of Science
Eligible to supervise Masters and PhD, but is currently at capacity - email supervisor to discuss availability.
Dr Tatiana Soares da Costa is an Australian Research Council Future Fellow and the Head of the Herbicide and Antimicrobial Innovation Laboratory at The University of Adelaide's Waite campus.
Dr Soares da Costa leads a research team dedicated to developing innovative strategies to mitigate the rise in herbicide and antimicrobial resistance that threatens the global agricultural and health industries. Dr Soares da Costa's team have applied their expertise in protein biochemistry, plant biology, chemistry and microbiology to make several breakthrough discoveries:
- Discovery of the first inhibitors of lysine biosynthesis with herbicidal activity. This discovery demonstrates that inhibition of lysine biosynthesis represents a novel herbicide mode of action. Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants | eLife (elifesciences.org)
- First report of a dual-target herbicidal compound, i.e., a compound that inhibits two targets simultaneously to impede the generation of resistance in weeds. Multi-target compounds allow us to progress the herbicide field beyond the ‘one target–one herbicide’ paradigm. A dual-target herbicidal inhibitor of lysine biosynthesis | eLife (elifesciences.org)
- Discovery that we can modify the structure of failed antibiotics and turn them into herbicides that are effective against weeds. This study highlights an innovative strategy to fast-track the development of herbicides. Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity | Communications Biology (nature.com)
- Determination of >30 protein crystal structures of unexplored herbicide and antibiotic targets. This has allowed the discovery of herbicidal and antimicrobial compounds with high potency and specificity. Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria | PNAS; Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus* - Journal of Biological Chemistry (jbc.org)
Dr Soares da Costa has published >50 journal articles and has been awarded >$5M in competitive funding as sole or lead chief investigator, including an NHMRC Peter Doherty Biomedical Fellowship (2015-2019), an ARC DECRA (2019-2022) and an ARC Future Fellowship (2024-2028). Her research has been recognised by >35 awards, including being named a 2023–24 Superstar of STEM (Science & Technology Australia), the 2023 Peter Goldacre Medallist (Australian Society of Plant Scientists) and the 2022 SA Young Tall Poppy of the Year (Australian Institute of Policy and Science). Dr Soares da Costa is passionate about science communication and promoting scientific research to the media, policymakers and the general community. She regularly gives radio interviews, writes newspaper/magazine articles, participates in community festivals and outreach at schools, and contributes to activities during University Open Days and National Science Week.
For more information on Dr Tatiana Soares da Costa's research, have a look at her laboratory webpage Herbicide and Antimicrobial Innovation Laboratory | School of Agriculture, Food & Wine | University of Adelaide, and profiles on LinkedIn and Research Gate. You can follow Tatiana on X/Twitter @Tatiana_Biochem and Bluesky @tatiana-biochem.bsky.social. To get in contact with her, please e-mail tatiana.soaresdacosta@adelaide.edu.au.
Dr Tatiana Soares da Costa is recruiting Honours, Masters and PhD students to work on various projects spanning biochemistry, chemistry, microbiology, molecular biology and plant biology. Please contact Tatiana directly with an expression of interest (tatiana.soaresdacosta@adelaide.edu.au).
Members of the Soares da Costa research group (from left to right). Dr Andrew Barrow (postdoctoral researcher), Dr Emily Mackie (postdoctoral researcher), Sreshtha Malik (PhD student), Olivia Oh (PhD student), Art Hussnain (MPhil student), Ryan McClean (PhD student), Mirrin McKay (PhD student) and Dr Tatiana Soares da Costa (Laboratory Head).
| Date | Position | Institution name |
|---|---|---|
| 2024 - ongoing | Group Leader and ARC Future Fellow | University of Adelaide |
| 2022 - 2024 | Group Leader and Future Making Fellow | University of Adelaide |
| 2019 - 2022 | Group Leader and ARC DECRA Fellow | La Trobe University |
| 2015 - 2019 | NHMRC Early Career Peter Doherty Fellow | La Trobe University |
| 2013 - 2015 | Teaching Only Lecturer | Charles Sturt University |
| Language | Competency |
|---|---|
| Portuguese | Can read, write, speak and understand spoken |
| Date | Institution name | Country | Title |
|---|---|---|---|
| The University of Adelaide | Australia | PhD | |
| University of Canterbury | New Zealand | Master of Science (First Class Honours) | |
| University of Canterbury | New Zealand | Bachelor of Science |
| Year | Citation |
|---|---|
| 2025 | Antoney, J., Kainrath, S., Dubowsky, J. G., Ahmed, F. H., Kang, S. W., Mackie, E. R. R., . . . Janovjak, H. (2025). A F420-dependent single domain chemogenetic tool for protein de-dimerization. Journal of Molecular Biology, 437(17), 169184-1-169184-17. |
| 2025 | Mackie, E. R. R., Mckay, M. V., Barrow, A. S., & da Costa, T. P. S. (2025). Inhibitors of lysine biosynthesis enzymes as potential new herbicides. Functional Plant Biology, 52(5), FP25030-1-FP25030-13. |
| 2023 | Javorsky, A., Maddumage, J. C., Mackie, E. R. R., Soares da Costa, T. P., Humbert, P. O., & Kvansakul, M. (2023). Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM. The FEBS journal, 290(4), 974-987. Scopus9 WoS9 Europe PMC9 |
| 2023 | Vujcic, B., Wyllie, J., Tania., Burns, J., White, K. F., Cromwell, S., . . . Houston, S. D. (2023). Cage Hydrocarbons as Linkers in Dimeric Drug Design: Case Studies with Trimethoprim and Tedizolid. Bioorganic and Medicinal Chemistry Letters, 80, 129086-1-129086-5. Scopus4 WoS5 Europe PMC1 |
| 2023 | Ottonello, A., Wyllie, J. A., Yahiaoui, O., Sun, S., Koelln, R. A., Homer, J. A., . . . Moses, J. E. (2023). Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.. Proceedings of the National Academy of Sciences of the United States of America, 120(15), e2208737120. Scopus18 WoS16 Europe PMC10 |
| 2023 | Mackie, E. R. R., Barrow, A. S., Giel, M. -C., Hulett, M. D., Gendall, A. R., Panjikar, S., & Soares da Costa, T. P. (2023). Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity. Communications Biology, 6(1), 1-11. Scopus3 WoS3 Europe PMC4 |
| 2023 | Christoff, R. M., Al Bayer, M., Soares da Costa, T. P., Perugini, M. A., & Abbott, B. M. (2023). Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds. RSC Medicinal Chemistry, 14(9), 1698-1703. Scopus3 |
| 2022 | Soares da Costa, T., Wyllie, J., Ghardi, C., Hulett, M., Abbott, B., Sutton, M., & Perugini, M. (2022). The First Inhibitor of <i>Meso</i>-Diaminopimelate Biosynthesis with Antibacterial Activity Against Multi-Drug Resistant Bacteria. Europe PMC1 |
| 2022 | Mackie, E. R. R., Barrow, A. S., Christoff, R. M., Abbott, B. M., Gendall, A. R., & Soares da Costa, T. P. (2022). A dual-target herbicidal inhibitor of lysine biosynthesis. eLife, 11, 1-11. Scopus8 WoS7 Europe PMC6 |
| 2022 | Wyllie, J. A., McKay, M. V., Barrow, A. S., & Soares da Costa, T. P. (2022). Biosynthesis of uridine diphosphate N-Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?. IUBMB life, 71(12), 1232-1252. Scopus13 WoS11 Europe PMC10 |
| 2022 | Mather, J. C., Wyllie, J. A., Hamilton, A., Soares da Costa, T. P., & Barnard, P. J. (2022). Antibacterial silver and gold complexes of imidazole and 1,2,4-triazole derived N-heterocyclic carbenes. Dalton Transactions, 51(32), 12056-12070. Scopus26 WoS24 Europe PMC12 |
| 2022 | Teakel, S., Marama, M., Aragao, D., Tsimbalyuk, S., Mackie, E. R. R., da Costa, T. P. S., . . . Cahill, M. A. (2022). Structural characterisation of a MAPR-related archaeal cytochrome b(5M) protein. FEBS Letters, 596(18), 2409-2417. Scopus3 WoS3 Europe PMC2 |
| 2021 | Christoff, R. M., Soares da Costa, T. P., Bayat, S., Holien, J. K., Perugini, M. A., & Abbott, B. M. (2021). Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase. Bioorganic and Medicinal Chemistry, 52, 116518-1-116518-9. Scopus7 WoS7 Europe PMC6 |
| 2021 | Wines, B. D., Trist, H. M., Esparon, S., Impey, R. E., Mackay, G. A., Andrews, R. K., . . . Hogarth, P. M. (2021). Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2. Frontiers in Immunology, 12, 666813-1-666813-13. Scopus3 WoS3 Europe PMC3 |
| 2021 | Nonis, S. G., Haywood, J., Schmidberger, J. W., Mackie, E. R. R., Soares da Costa, T. P., Bond, C. S., & Mylne, J. S. (2021). Structural and biochemical analyses of concanavalin A circular permutation by jack bean asparaginyl endopeptidase. Plant Cell, 33(8), 2794-2811. Scopus24 WoS20 Europe PMC17 |
| 2021 | Soares da Costa, T. P., Hall, C. J., Panjikar, S., Wyllie, J. A., Christoff, R. M., Bayat, S., . . . Perugini, M. A. (2021). Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants. eLife, 10, 1-17. Scopus21 WoS17 Europe PMC16 |
| 2021 | Hall, C. J., Lee, M., Boarder, M. P., Mangion, A. M., Gendall, A. R., Panjikar, S., . . . Soares da Costa, T. P. (2021). Differential lysine-mediated allosteric regulation of plant dihydrodipicolinate synthase isoforms. FEBS Journal, 288(16), 4973-4986. Scopus9 WoS8 Europe PMC6 |
| 2020 | Li, Z., MacKie, E. R. R., Ramkissoon, P., Mather, J. C., Wiratpruk, N., Soares Da Costa, T. P., & Barnard, P. J. (2020). Synthesis, conformational analysis and antibacterial activity of Au(I)-Ag(I) and Au(I)-Hg(II) heterobimetallic N-heterocyclic carbene complexes. Dalton Transactions, 49(36), 12820-12834. Scopus14 WoS14 Europe PMC7 |
| 2020 | Impey, R. E., Hawkins, D. A., Sutton, J. M., & Soares da Costa, T. P. (2020). Overcoming intrinsic and acquired resistance mechanisms associated with the cell wall of gram-negative bacteria. Antibiotics, 9(9), 1-19. Scopus70 WoS63 Europe PMC47 |
| 2020 | Suraweera, C. D., Anasir, M. I., Chugh, S., Javorsky, A., Impey, R. E., Hasan Zadeh, M., . . . Kvansakul, M. (2020). Structural insight into tanapoxvirus-mediated inhibition of apoptosis. FEBS Journal, 287(17), 3733-3750. Scopus14 WoS13 Europe PMC12 |
| 2020 | Impey, R. E., Lee, M., Hawkins, D. A., Sutton, J. M., Panjikar, S., Perugini, M. A., & Soares da Costa, T. P. (2020). Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens. FEBS Letters, 594(9), 1453-1463. Scopus4 WoS4 Europe PMC3 |
| 2020 | Young, N. D., Harris, T. J., Evangelista, M., Tran, S., Wouters, M. A., Soares da Costa, T. P., . . . Fairlie, W. D. (2020). Diversity in the intrinsic apoptosis pathway of nematodes. Communications Biology, 3(1), 478-1-478-12. Scopus5 WoS4 Europe PMC3 |
| 2020 | Bleackley, M. R., Vasa, S., Harvey, P. J., Shafee, T. M. A., Kerenga, B. K., Soares da Costa, T. P., . . . Anderson, M. A. (2020). Histidine-rich defensins from the solanaceae and brasicaceae are antifungal and metal binding proteins. Journal of Fungi, 6(3), 1-14. Scopus11 WoS11 Europe PMC9 |
| 2020 | Hall, C. J., Mackie, E. R. R., Gendall, A. R., Perugini, M. A., & Soares da Costa, T. P. (2020). Review: amino acid biosynthesis as a target for herbicide development. Pest Management Science, 76(12), 3896-3904. Scopus25 WoS20 Europe PMC18 |
| 2020 | Giel, M. C., Smedley, C. J., Mackie, E. R. R., Guo, T., Dong, J., Soares da Costa, T. P., & Moses, J. E. (2020). Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides. Angewandte Chemie - International Edition, 59(3), 1181-1186. Scopus77 WoS75 Europe PMC31 |
| 2020 | Impey, R. E., Panjikar, S., Hall, C. J., Bock, L. J., Sutton, J. M., Perugini, M. A., & Soares da Costa, T. P. (2020). Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation. The Federation of European Biochemical Societies (FEBS) Journal, 287(2), 386-400. Scopus15 WoS15 Europe PMC13 |
| 2020 | Suraweera, C. D., Anasir, M. I., Chugh, S., Javorsky, A., Impey, R. E., Zadeh, M. H., . . . Kvansakul, M. (2020). Structural insight into tanapoxvirus mediated inhibition of apoptosis. |
| 2020 | Sakthivel, D., Preston, S., Gasser, R. B., Costa, T. P. S. D., Hernandez, J. N., Shahine, A., . . . Beddoe, T. (2020). The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries). Communications Biology, 3(1), 464. Scopus7 Europe PMC6 |
| 2019 | Gilson, P. R., Kumarasingha, R., Thompson, J., Zhang, X., Penington, J. S., Kalhor, R., . . . Abbott, B. M. (2019). A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4. Scientific Reports, 9(1), 1-15. Scopus24 WoS23 Europe PMC20 |
| 2019 | Lee, E. F., Smith, N. A., Soares da Costa, T. P., Meftahi, N., Yao, S., Harris, T. J., . . . Fairlie, W. D. (2019). Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1. Autophagy, 15(5), 785-795. Scopus42 WoS39 Europe PMC39 |
| 2019 | Christoff, R. M., Gardhi, C. K., Soares Da Costa, T. P., Perugini, M. A., & Abbott, B. M. (2019). Pursuing DHDPS: An enzyme of unrealised potential as a novel antibacterial target. MedChemComm, 10(9), 1581-1588. Scopus10 WoS10 |
| 2018 | Gupta, R., Hogan, C. J., Perugini, M. A., & Soares da Costa, T. P. (2018). Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum. Planta, 248(2), 381-391. Scopus7 WoS6 Europe PMC5 |
| 2018 | Soares da Costa, T. P., Abbott, B. M., Gendall, A. R., Panjikar, S., & Perugini, M. A. (2018). Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis. Biophysical Reviews, 10(2), 153-162. Scopus17 Europe PMC13 |
| 2018 | North, R. A., Wahlgren, W. Y., Remus, D. M., Scalise, M., Kessans, S. A., Dunevall, E., . . . Dobson, R. C. J. (2018). The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity. Frontiers in Chemistry, 6(JUL), 233-1-233-11. Scopus20 Europe PMC22 |
| 2018 | Smith, K. M., Tsimbalyuk, S., Edwards, M. R., Cross, E. M., Batra, J., Soares da Costa, T. P., . . . Forwood, J. K. (2018). Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nature Communications, 9(1), 1-13. Scopus61 WoS60 Europe PMC60 |
| 2018 | Stifter, S. A., Matthews, A. Y., Mangan, N. E., Fung, K. Y., Drew, A., Tate, M. D., . . . Hertzog, P. J. (2018). Defining the distinct, intrinsic properties of the novel type i interferon, IFNϵ. Journal of Biological Chemistry, 293(9), 3168-3179. Scopus38 WoS37 Europe PMC35 |
| 2018 | Gupta, R., Soares da Costa, T. P., Faou, P., Dogovski, C., & Perugini, M. A. (2018). Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae. Protein Expression and Purification, 145, 85-93. Scopus12 WoS12 Europe PMC9 |
| 2018 | Hall, C. J., & Soares da Costa, T. P. (2018). Lysine: biosynthesis, catabolism and roles. Wikijournal of Science, 1(1). Scopus14 |
| 2017 | Ellisdon, A. M., Nold-Petry, C. A., D’Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., . . . Nold, M. F. (2017). Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Science Immunology, 2(8), 1-12. Scopus55 WoS50 Europe PMC43 |
| 2017 | Soares da Costa, T. P., Patel, M., Desbois, S., Gupta, R., Faou, P., & Perugini, M. A. (2017). Identification of a dimeric KDG aldolase from Agrobacterium tumefaciens. Proteins: Structure, Function and Bioinformatics, 85(11), 2058-2065. Scopus8 WoS7 Europe PMC8 |
| 2017 | Soares Da Costa, T. P., Nanson, J. D., & Forwood, J. K. (2017). Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes. Scientific Reports, 7(1), 1-9. Scopus8 WoS8 Europe PMC6 |
| 2016 | Miles, N. G., & Soares da Costa, T. P. (2016). Acceptance of clickers in a large multimodal biochemistry class as determined by student evaluations of teaching: Are they just an annoying distraction for distance students?. Biochemistry and Molecular Biology Education, 44(1), 99-108. Scopus8 WoS5 Europe PMC2 |
| 2016 | Christensen, J. B., Soares Da Costa, T. P., Faou, P., Pearce, F. G., Panjikar, S., & Perugini, M. A. (2016). Structure and Function of Cyanobacterial DHDPS and DHDPR. Scientific Reports, 6(1), 12 pages. Scopus25 WoS20 Europe PMC20 |
| 2016 | Peverelli, M. G., Soares da Costa, T., Kirby, N., & Perugini, M. A. (2016). Dimerization of bacterial diaminopimelate decarboxylase is essential for catalysis. Journal of Biological Chemistry, 291(18), 9785-9795. Scopus38 WoS36 Europe PMC32 |
| 2016 | da Costa, T. P. S. (2016). Conference survival guide-the dos and don'ts. CELL DEATH DISCOVERY, 2(1), 3 pages. Scopus2 WoS1 Europe PMC2 |
| 2016 | Soares da Costa, T. P., Desbois, S., Dogovski, C., Gorman, M. A., Ketaren, N. E., Paxman, J. J., . . . Perugini, M. A. (2016). Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target. Structure, 24(8), 1282-1291. Scopus34 WoS31 Europe PMC28 |
| 2016 | Soares da Costa, T. P. (2016). Supervisor types: which one is your match?. Cell Death Discovery, 2(1), 2 pages. Scopus3 |
| 2015 | Tieu, W., Polyak, S., Paparella, A., Yap, M., Soares Da Costa, T., Ng, B., . . . Abell, A. (2015). Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery. ACS Medicinal Chemistry Letters, 6(2), 216-220. Scopus18 WoS18 Europe PMC9 |
| 2014 | Tieu, W., Jarrad, A. M., Paparella, A. S., Keeling, K. A., Soares da Costa, T. P., Wallace, J. C., . . . Abell, A. D. (2014). Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase. Bioorganic & Medicinal Chemistry Letters, 24(19), 4689-4693. Scopus21 WoS20 Europe PMC10 |
| 2014 | Paparella, A., Soares Da Costa, T., Yap, M., Tieu, W., Wilce, M., Booker, G., . . . Polyak, S. (2014). Structure guided design of biotin protein ligase inhibitors for antibiotic discovery. Current Topics in Medicinal Chemistry, 14(1), 4-20. Scopus27 WoS27 Europe PMC17 |
| 2014 | Soares da Costa, T., Yap, M., Perugini, M., Wallace, J., Abell, A., Wilce, M., . . . Booker, G. (2014). Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus. Molecular Microbiology, 91(1), 110-120. Scopus23 WoS20 Europe PMC17 |
| 2013 | Tieu, W., Soares da Costa, T., Yap, M., Keeling, K., Wilce, M., Wallace, J., . . . Abell, A. (2013). Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitors. Chemical Science, 4(9), 3533-3537. Scopus39 WoS39 |
| 2012 | Soares da Costa, T., Tieu, W., Yap, M., Zvarec, O., Bell, J., Turnidge, J., . . . Polyak, S. (2012). Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase. ACS Medicinal Chemistry Letters, 3(6), 509-514. Scopus41 WoS40 Europe PMC27 |
| 2012 | Soares da Costa, T., Tieu, W., Yap, M., Pendini, N., Polyak, S., Pedersen, D., . . . Abell, A. (2012). Selective inhibition of biotin protein ligase from Staphylococcus aureus. Journal of Biological Chemistry, 287(21), 17823-17832. Scopus63 WoS56 Europe PMC42 |
| 2012 | Mayende, L., Swift, R., Bailey, L., Soares da Costa, T., Wallace, J., Booker, G., & Polyak, S. (2012). A novel molecular mechanism to explain biotin-unresponsive holocarboxylase synthetase deficiency. Journal of Molecular Medicine-JMM, 90(1), 81-88. Scopus28 WoS27 Europe PMC22 |
| 2010 | Soares da Costa, T. P., Muscroft-Taylor, A. C., Dobson, R. C. J., Devenish, S. R. A., Jameson, G. B., & Gerrard, J. A. (2010). How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?. Biochimie, 92(7), 837-845. Scopus34 WoS32 Europe PMC25 |
| 2010 | Muscroft-Taylor, A. C., Soares da Costa, T. P., & Gerrard, J. A. (2010). New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry. Biochimie, 92(3), 254-262. Scopus27 WoS24 Europe PMC19 |
| Year | Citation |
|---|---|
| 2020 | Gaskin, S. M., Soares Da Costa, T. P., & Hulett, M. D. (2020). Heparanase: Cloning, Function and Regulation. In Advances in Experimental Medicine and Biology (Vol. 1221, pp. 189-229). Springer International Publishing. DOI Scopus11 WoS12 Europe PMC11 |
| 2015 | Soares Da Costa, T. P., Christensen, J. B., Desbois, S., Gordon, S. E., Gupta, R., Hogan, C. J., . . . Perugini, M. A. (2015). Quaternary Structure Analyses of an Essential Oligomeric Enzyme. In J. L. Cole (Ed.), Methods in Enzymology (Vol. 562, pp. 205-223). ELSEVIER ACADEMIC PRESS INC. DOI Scopus22 WoS18 Europe PMC17 |
| Year | Citation |
|---|---|
| 2022 | Antoney, J., Kainrath, S., Ahmed, H., Kang, S. W., Mackie, E., Soares da Costa, T., . . . Janovjak, H. (2022). A F<sub>420</sub>-dependent single domain chemogenetic tool for protein de-dimerization. DOI |
| 2022 | Mackie, E., Barrow, A., Christoff, R., Abbott, B., Gendall, A., & Soares da Costa, T. (2022). A dual-target herbicidal inhibitor of lysine biosynthesis. DOI |
| Year | Funding | Role | Amount |
| 2025–2028 | ARC Discovery Project (DP250102939): Learning lessons from drug resistance to tackle herbicide resistance | Lead CI | $666,653 |
| 2024–2028 | ARC Future Fellowship (FT230100203): Striving for the path of least herbicide resistance | Sole CI | $830,380 |
| 2023–2027 | ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ICC220100050) | CI | $4,508,426 |
| 2023–2025 | NHMRC Ideas Grant (APP2020758): A novel dual therapy approach to treatment of multidrug-resistant Gram-negative infections | CI | $981,046 |
| 2022–2025 | ARC Discovery Project (DP220101901): Re-purposing shelved ‘antibiotics’ in the search for new herbicides | Lead CI | $446,368 |
| 2022–2025 | Hermon Slade Foundation: Towards novel diagnostic tools to monitor and combat herbicide resistance | Lead CI | $77,842 |
| 2022–2024 | South Australian Potato Industry Trust Fund: New herbicides for effective weed control in potato cropping systems | Sole CI | $85,477 |
| 2022–2024 | Australian Academy of Science Thomas Davies Research Grant for Marine, Soil and Plant Biology: Using supercomputers in the search for herbicides that inhibit amino acid production in plants | Sole CI | $19,960 |
| 2022–2023 | Yitpi Foundation Grant: Herbicides with new active ingredients for effective wheat protection | Sole CI | $14,500 |
| 2019–2022 | ARC Discovery Early Career Researcher Award (DE190100806): Towards herbicide cocktails with a new mode of action to avert resistance | Sole CI | $419,854 |
| 2019–2022 | Australian Academy of Science JG Russell Award (to support the ARC DECRA) | Sole CI | $6,000 |
| 2020–2022 | Defence Science Institute Research Higher Degree Stipend (to fund an HDR student): Combating the resistance crisis: Towards new antibiotic and herbicide targets | Sole CI | $15,000 |
| 2020–2022 | Defence Science Institute Research Higher Degree Scholarship (to fund an HDR student): Fighting superbugs with novel drugs to tackle resistance | Sole CI | $15,000 |
| 2019–2022 | Grains Research and Development Corporation Research Higher Degree Scholarship (to fund an HDR student): Development of herbicide cocktails with a novel mode of action for circumventing resistance mechanisms | $107,091 | |
| 2015–2019 | NHMRC Early Career Fellowship (APP1091976): Broad spectrum inhibition of an enzyme antibiotic target | Sole CI | $309,436 |
2022–2024: Honours Coordinator, School of Agriculture, Food and Wine
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2025 | Principal Supervisor | Structural and functional characterisation of protein targets to guide the design of novel herbicides | Master of Philosophy | Master | Full Time | Chaudhry Artemiy Hussnain |
| 2025 | Principal Supervisor | Integration of Experimental Approaches for Exploration and Development of Novel Antifungal Agents: Addressing Emerging Resistance Challenges | Doctor of Philosophy | Doctorate | Full Time | Miss Olivia Pei Ying Oh |
| 2025 | Principal Supervisor | Targeted Herbicide Development: Exploring Novel Modes of Action to Combat Resistance | Doctor of Philosophy | Doctorate | Full Time | Ms Lilitha Njobe |
| 2025 | Principal Supervisor | Integration of Experimental Approaches for Exploration and Development of Novel Antifungal Agents: Addressing Emerging Resistance Challenges | Doctor of Philosophy | Doctorate | Full Time | Miss Olivia Pei Ying Oh |
| 2025 | Principal Supervisor | Structural and functional characterisation of protein targets to guide the design of novel herbicides | Master of Philosophy | Master | Full Time | Chaudhry Artemiy Hussnain |
| 2025 | Principal Supervisor | Targeted Herbicide Development: Exploring Novel Modes of Action to Combat Resistance | Doctor of Philosophy | Doctorate | Full Time | Ms Lilitha Njobe |
| 2024 | Co-Supervisor | Preclinical evaluation of new derivatives of the anticoccidial drug robenidine as novel antibacterial agents | Doctor of Philosophy | Doctorate | Full Time | Ms Sayara Bista |
| 2024 | Co-Supervisor | Identify and characterise plant glycosyltransferases involved in critical components of cell wall biosynthesis: identifying essential building blocks for efficient bioenergy production. | Doctor of Philosophy | Doctorate | Full Time | Miss Xingyi Zhou |
| 2024 | Co-Supervisor | Preclinical evaluation of new derivatives of the anticoccidial drug robenidine as novel antibacterial agents | Doctor of Philosophy | Doctorate | Full Time | Ms Sayara Bista |
| 2024 | Co-Supervisor | Identify and characterise plant glycosyltransferases involved in critical components of cell wall biosynthesis: identifying essential building blocks for efficient bioenergy production. | Doctor of Philosophy | Doctorate | Full Time | Miss Xingyi Zhou |
| 2023 | Principal Supervisor | Unlocking the Value of Lysine for Sustainable Agriculture | Doctor of Philosophy | Doctorate | Full Time | Miss Mirrin McKay |
| 2023 | Principal Supervisor | Unlocking the Value of Lysine for Sustainable Agriculture | Doctor of Philosophy | Doctorate | Full Time | Miss Mirrin McKay |
| 2022 | Principal Supervisor | Developing novel strategies to monitor and combat herbicide resistance | Doctor of Philosophy | Doctorate | Full Time | Ms Sreshtha Malik |
| 2022 | Principal Supervisor | A novel repurposing approach for herbicide discovery to combat resistant weeds | Doctor of Philosophy | Doctorate | Full Time | Mr Ryan James Francis McClean |
| 2022 | Principal Supervisor | Developing novel strategies to monitor and combat herbicide resistance | Doctor of Philosophy | Doctorate | Full Time | Ms Sreshtha Malik |
| 2022 | Principal Supervisor | A novel repurposing approach for herbicide discovery to combat resistant weeds | Doctor of Philosophy | Doctorate | Full Time | Mr Ryan James Francis McClean |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2022 - 2023 | Principal Supervisor | Strategies to Circumvent Herbicide Resistance Through the Inhibition of Lysine Biosynthesis | Doctor of Philosophy | Doctorate | Full Time | Dr Emily Rose Ronayne Mackie |
| 2022 - 2024 | Principal Supervisor | Exploring Alternative Strategies in Antibiotic Discovery to Tackle Multidrug-Resistant Bacteria | Doctor of Philosophy | Doctorate | Full Time | Miss Jessica Anne Wyllie |
| 2022 - 2025 | Principal Supervisor | Investigating Novel Antibiotic and Herbicide Targets to Circumvent Resistance | Doctor of Philosophy | Doctorate | Part Time | Mr Daniel Adam Hawkins |
| Date | Role | Board name | Institution name | Country |
|---|---|---|---|---|
| 2020 - ongoing | Board Member | Board of Directors | Science & Technology Australia | Australia |
| 2019 - ongoing | Member | Executive Committee | Australian Society for Biochemistry and Molecular Biology | Australia |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2016 - ongoing | Editor | Editor | Australian Biochemist Magazine | Australia |
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