Andrea Yool

Research Interests

Basic Pharmacology Biochemistry and Cell Biology Cancer Therapy Neurosciences Pharmacology and Pharmaceutical Sciences Proteins and Peptides Cancer Biology and Clinical Oncology Neuroscience, Behaviour and Brain Health Translational Health Outcomes Innovative Therapeutics

Prof Andrea Yool

Professor of Physiology

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Andrea is a Professor of Physiology at the University of Adelaide, South Australia, and a member of the Institute for Photonics and Advanced Sensing. She obtained her PhD in Physiology and Cell Biology from the University of California Santa Barbara, and subsequently worked as a research fellow in Neuropharmacology at Scripps Clinic & Research Foundation in California. After further postdoctoral research in Molecular & Cellular Physiology at Stanford University, she was appointed as an academic staff member in the Dept of Physiology at the University of Arizona, with joint appointments in the Dept of Pharmacology and the Division of Neuroscience. She moved to Australia as Professor and Head of Physiology at the University of Adelaide in 2007. She has a strong publication record in ion channel and water channel physiology, with more than 100 publications, book chapters and review articles in total. More than 70 papers feature her as first or senior author, including work in top tier journals (Science, Nature and PNAS). She has catalysed excellence in research scholarship having supervised research projects for more than 40 Bachelor and Honours students, and served as principal or co-supervisor to over 60 HDR students, and 5 postdoctoral fellows and MD/PhD research fellows, over her career.Her goals as director of Aquaporin Physiology and Drug Discovery Program are to define the molecular basis of the dual water and ion channel function of aquaporins (AQPs), to understand the roles of AQPs in physiological systems, and to build a definitive portfolio of AQP antagonist and agonist compounds as tools for basic research and clinical innovation.

Research

AQUAPORIN PHYSIOLOGY AND DRUG DISCOVERY RESEARCH PROGRAM

The water channels known as aquaporins (AQPs) are an ancient family found in all the kingdoms of life, from bacteria and plants to invertebrates and vertebrates. They play key roles in water balance and fluid homeostasis, cell volume and motility.  The thirteen classes of human AQPs show tissue-specific patterns of expression relevant to health and disease. Our goals are to define the molecular basis of the dual water and ion channel functions of aquaporins, to understand the roles of AQPs in physiological systems, and to build a definitive portfolio of AQP antagonist and agonist compounds as tools for basic research and clinical innovation. Aquaporins are currently being uncovered as essential components of rapid cell migration in normal development, wound healing and cancer metastasis (particularly in aggressive cancers such as glioblastoma and colon cancers).  AQPs also are emerging as important components for signal transduction in sensory systems.  Our work over the past decade has challenged the original dogma that the archetypal channel AQP1 is rigid and constitutively open.  We  have shown that AQP1 is regulated by intracellular signals and serves as cGMP-gated ion channel as well as an osmotic water channel.  Our focus on AQP pharmacology defined the first library of pharmacological agents in the world, based on arylsulfonamide scaffolds showing differential activities on the ion and the water pores.  We are also discovering new pharmacological AQP modulators from traditional Chinese and Indian herbal medicines, identifying the active chemical components and defining their molecular targets of action on AQP gating domains.  Our findings could offer exciting opportunities for clinical intervention in cancer metastasis, brain oedema, hydrocephalus, and other fluid transport disorders. Our drug agents are currently being tested in vivo in collaborative projects in Australia, Europe and the USA.

Slide title page An overview of AQP research was covered in a plenary talk by Andrea at the first international Aquaporins Solutions conference in Nov 2020 sponsored by Australian National University, available to Uni Adelaide staff and students for viewing at this OneDrive link (24 min):

     New Views of Aquaporins

--CURRENT RESEARCH PROJECTS--

Project 1. Using cell culture, molecular biology, expression systems, imaging, and pharmacological tools to define mechanisms and discover novel drugs for controlling the invasiveness of glioblastoma (brain cancer) cells. (Collaboration with Dr Sunita Ramesh, Flinders University; Prof Rainer Haberberger, UofA; and Dr Rohan Davis, Griffith Uni QLD). Available  for  Honours and HDR placements in 2025.

Project 2. Exploring the roles of aquaporin channels in the tongue as signal transduction mechanisms in sensory system function. (Collaboration with Damian Espinase Nandorfy and Dr Leigh Francis at the Australian Wine Research Institute, UofA). Available for Honours placements in 2024.

Project 3.  Discovering new pharmacological modulators of cell motility in natural products including traditional Chinese medicinal herbs. Available for Honours placements in 2024

Location-- Available research projects will be conducted in the Yool laboratory, Helen Mayo South, level 2, Frome Rd (North Terrace campus). 

Special requirements--  None; however Physiology courses (PHYSIOL 2510, 2520, 3104), and a background in first year chemistry, biochemistry or the equivalent are highly recommended.

Date Position Institution name
2007 - ongoing Professor of Physiology University of Adelaide
2004 - 2007 Professor University of Arizona
1998 - 2004 Associate Professor University of Arizona
1992 - 1998 Assistant Professor University of Arizona

Date Institution name Country Title
1980 - 1985 University of California, Santa Barbara United States PhD

Date Title Institution Country
1990 - 1992 Postdoctoral Scholar Stanford University United States
1985 - 1989 Postdoctoral Research Fellow Scripps Research Institute United States

Year Citation
2026 Wagner, K. K., Fotiou, M., Suo, S. J., Ramesh, S. A., Davis, R. A., & Yool, A. J. (2026). Semisynthetic indole alkaloids restrain the invasiveness of glioblastoma cell lines and inhibit human Aquaporin-1 water channels. Biochemical Pharmacology, 244, 16 pages.
DOI
2025 Al-Samir, S., Kyriazi, D., Yool, A. J., Moser, I., Kyriazi, K., Gros, G., . . . Endeward, V. (2025). Aquaporin-1 acts as an O2 channel. The permeability of human and mouse red cell membranes for oxygen.. Am J Physiol Cell Physiol, 328(5), C1605-C1622.
DOI Scopus2 WoS2 Europe PMC8
2025 Espinase Nandorfy, D., Khan, S., Wang, S., Kulathunga, B., Peirce, E., & Yool, A. J. (2025). Astringent Effects of Red Wine Associated with Responses of Aquaporins Found in Human Tongue and Salivary Tissues.. J Agric Food Chem, 73(33), 21035-21047.
DOI Scopus1 WoS1
2024 Ahmed, J., Ismail, A., Ding, L., Yool, A. J., & Chaumont, F. (2024). A new method to measure aquaporin-facilitated membrane diffusion of hydrogen peroxide and cations in plant suspension cells. Plant, Cell and Environment, 47(2), 527-539.
DOI Scopus9 WoS9 Europe PMC8
2024 Amro, Z., Collins-Praino, L. E., & Yool, A. J. (2024). Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cells in response to oxidative and inflammatory stressors.. Biosci Rep, 44(3), 21 pages.
DOI Scopus11 WoS12 Europe PMC10
2024 Nourmohammadi, S., Henderson, S. W., Ramesh, S. A., & Yool, A. J. (2024). Characterization of human Aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery. Bioscience Reports: molecular and cellular biology of the cell surface, 44(8), BSR20240542-1-BSR20240542-20.
DOI Scopus1 WoS1 Europe PMC1
2023 Varricchio, A., & Yool, A. J. (2023). Aquaporins and Ion Channels as Dual Targets in the Design of Novel Glioblastoma Therapeutics to Limit Invasiveness. Cancers, 15(3), 849.
DOI Scopus6 WoS6 Europe PMC4
2023 Varricchio, A., Khan, S., Price, Z. K., Davis, R. A., Ramesh, S. A., & Yool, A. J. (2023). Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro. Cancers, 15(4), 1-20.
DOI Scopus13 WoS13 Europe PMC10
2023 Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15.
DOI Scopus4 WoS4 Europe PMC3
2023 Varricchio, A., Yool, A. J., & Ramesh, S. A. (2023). Subtype-specific block of glioblastoma motility through dual inhibition of water and ion flux. Biophysical Journal, 122(3), 255a-256a.
DOI
2023 Amro, Z., Ryan, M., Collins-Praino, L. E., & Yool, A. J. (2023). Unexpected Classes of Aquaporin Channels Detected by Transcriptomic Analysis in Human Brain Are Associated with Both Patient Age and Alzheimer’s Disease Status. Biomedicines, 11(3), 1-19.
DOI Scopus11 WoS11 Europe PMC11
2023 Khan, S., Lokman, N. A., Oehler, M. K., Ricciardelli, C., & Yool, A. J. (2023). Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. Cancers, 15(18), 4507-1-4507-27.
DOI Scopus1 WoS1 Europe PMC1
2022 Khan, S., Varricchio, A., Ricciardelli, C., & Yool, A. J. (2022). Invasiveness of endometrial cancer cell lines is potentiated by estradiol and blocked by a traditional medicine Guizhi Fuling at clinically relevant doses.. Frontiers in Oncology, 12, 15 pages.
DOI Scopus5 WoS5 Europe PMC5
2022 Salman, M. M., Kitchen, P., Yool, A. J., & Bill, R. M. (2022). Recent breakthroughs and future directions in drugging aquaporins. Trends in Pharmacological Sciences, 43(1), 30-42.
DOI Scopus81 WoS83 Europe PMC80
2022 Henderson, S. W., Nourmohammadi, S., Ramesh, S. A., & Yool, A. J. (2022). Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology. Biophysical Reviews, 14(1), 181-198.
DOI Scopus17 WoS16 Europe PMC13
2022 Wagner, K., Unger, L., Salman, M. M., Kitchen, P., Bill, R. M., & Yool, A. J. (2022). Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease. International Journal of Molecular Sciences, 23(3), 1388.
DOI Scopus88 WoS80 Europe PMC70
2021 Chow, P. H., Cox, C. D., Pei, J. V., Anabaraonye, N., Nourmohammadi, S., Henderson, S. W., . . . Yool, A. J. (2021). Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling.. Frontiers in pharmacology, 12, 1-13.
DOI Scopus6 WoS6 Europe PMC6
2021 Tomita, Y., Smith, E., Palethorpe, H. M., Nakhjavani, M., Yeo, K. K. L., Townsend, A. R., . . . Hardingham, J. E. (2021). In vitro synergistic inhibition of HT-29 proliferation and 2H-11 and HUVEC tubulogenesis by bacopaside I and II Is associated with Ca²⁺ flux and loss of plasma membrane integrity. Pharmaceuticals, 14(5), 1-18.
DOI Scopus5 WoS4 Europe PMC2
2021 Nakhjavani, M., Smith, E., Yeo, K., Tomita, Y., Price, T. J., Yool, A., . . . Hardingham, J. E. (2021). Differential antiangiogenic and anticancer activities of the active metabolites of ginsenoside Rg3. Journal of Ginseng Research, 48(2), 10 pages.
DOI Scopus8 WoS9 Europe PMC7
2021 Amro, Z., Yool, A. J., & Collins-Praino, L. E. (2021). The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathies. Brain, behavior, & immunity - health, 14, 100242-1-100242-14.
DOI Scopus27 WoS24 Europe PMC23
2021 Varricchio, A., Ramesh, S. A., & Yool, A. J. (2021). Novel ion channel targets and drug delivery tools for controlling glioblastoma cell invasiveness. International Journal of Molecular Sciences, 22(21), 11909-1-11909-22.
DOI Scopus11 WoS11 Europe PMC10
2021 Khan, S., Ricciardelli, C., & Yool, A. J. (2021). Targeting aquaporins in novel therapies for male and female breast and reproductive cancers. Cells, 10(2), 1-18.
DOI Scopus21 WoS19 Europe PMC17
2021 Tyerman, S. D., McGaughey, S. A., Qiu, J., Yool, A. J., & Byrt, C. S. (2021). Adaptable and multifunctional ion-conducting aquaporins. Annual Review of Plant Biology, 72(1), 1-34.
DOI Scopus85 WoS76 Europe PMC57
2020 Chow, P. H., Kourghi, M., Pei, J. V., Nourmohammadi, S., & Yool, A. J. (2020). 5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion. Mol Pharmacol, 98(1), 38-48.
DOI Scopus29 WoS28 Europe PMC23
2020 Fabrick, J. A., Yool, A. J., & Spurgeon, D. W. (2020). Insecticidal activity of marigold Tagetes patula plants and foliar extracts against the hemipteran pests, Lygus hesperus and Bemisia tabaci. PLoS ONE, 15(5), 15 pages.
DOI Scopus42 WoS29 Europe PMC10
2020 Chow, P. H., Bowen, J., & Yool, A. J. (2020). Combined systematic review and transcriptomic analyses of mammalian aquaporin classes 1 to 10 as biomarkers and prognostic indicators in diverse cancers. Cancers, 12(7), 1-31.
DOI Scopus26 WoS26 Europe PMC21
2020 Montiel, V., Bella, R., Michel, L. Y. M., Esfahani, H., De Mulder, D., Robinson, E. L., . . . Balligand, J. -L. (2020). Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Science Translational Medicine, 12(564), 1-16.
DOI Scopus57 WoS55 Europe PMC59
2020 Yool, A. J., & Ramesh, S. (2020). Molecular targets for combined therapeutic strategies to limit glioblastoma cell migration and invasion. Frontiers in Pharmacology, 11, 358-1-358-26.
DOI Scopus37 WoS36 Europe PMC28
2019 Pei, J. V., Heng, S., De Ieso, M. L., Sylvia, G., Kourghi, M., Nourmohammadi, S., . . . Yool, A. J. (2019). Development of a photoswitchable lithium-sensitive probe to analyze nonselective cation channel activity in migrating cancer cells. Molecular Pharmacology, 95(5), 573-583.
DOI Scopus25 WoS23 Europe PMC14
2019 Tomita, Y., Palethorpe, H. M., Smith, E., Nakhjavani, M., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2019). Bumetanide-derived aquaporin 1 inhibitors, AqB013 and AqB050 inhibit tube formation of endothelial cells through induction of apoptosis and impaired migration in vitro. International Journal of Molecular Sciences, 20(8), 1818-1-1818-11.
DOI Scopus20 WoS22 Europe PMC20
2019 Nourmohammadi, S., Aung, T. N., Cui, J., Pei, J., De Ieso, M. L., Harata-Lee, Y., . . . Yool, A. J. (2019). Effect of compound kushen injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Frontiers in Oncology, 9(APR), 1-14.
DOI Scopus53 WoS51 Europe PMC46
2019 Nakhjavani, M., Palethorpe, H. M., Tomita, Y., Smith, E., Price, T. J., Yool, A. J., . . . Hardingham, J. E. (2019). Stereoselective anti-cancer activities of ginsenoside Rg3 on triple negative breast cancer cell models. Pharmaceuticals, 12(3), 117-1-117-14.
DOI Scopus43 WoS36 Europe PMC30
2019 De Ieso, M. L., Pei, J. V., Nourmohammadi, S., Smith, E., Chow, P. H., Kourghi, M., . . . Yool, A. J. (2019). Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration. Scientific Reports, 9(1), 12635-1-12635-17.
DOI Scopus38 WoS33 Europe PMC29
2019 Aung, T. N., Nourmohammadi, S., Qu, Z., Harata-Lee, Y., Cui, J., Shen, H. Y., . . . Adelson, D. L. (2019). Fractional deletion of Compound Kushen Injection indicates cytokine signaling pathways are critical for its perturbation of the cell cycle. Scientific Reports, 9(1), 14200-1-14200-16.
DOI Scopus12 WoS10 Europe PMC14
2019 Palethorpe, H. M., Smith, E., Tomita, Y., Nakhjavani, M., Yool, A. J., Price, T. J., . . . Hardingham, J. E. (2019). Bacopasides I and II act in synergy to inhibit the growth, migration and invasion of breast cancer cell lines. Molecules, 24(19), 3539-1-3539-16.
DOI Scopus37 WoS32 Europe PMC25
2018 Smith, E., Palethorpe, H. M., Tomita, Y., Pei, J., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2018). The purified extract from the medicinal plant Bacopa monnieri, bacopaside II, inhibits growth of colon cancer cells in vitro by inducing cell cycle arrest and apoptosis. Cells, 7(7), 81-1-81-11.
DOI Scopus56 WoS51 Europe PMC40
2018 Kourghi, M., Pei, J., De Ieso, M., Nourmohammadi, S., Chow, P., & Yool, A. (2018). Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Clinical and Experimental Pharmacology and Physiology, 45(4), 401-409.
DOI Scopus42 WoS41 Europe PMC36
2018 Palethorpe, H., Tomita, Y., Smith, E., Pei, J., Townsend, A., Price, T., . . . Hardingham, J. (2018). The aquaporin 1 inhibitor bacopaside II reduces endothelial cell migration and tubulogenesis and induces apoptosis. International Journal of Molecular Sciences, 19(3), 653-1-653-10.
DOI Scopus31 WoS31 Europe PMC23
2018 De Ieso, M., & Yool, A. (2018). Mechanisms of aquaporin-facilitated cancer invasion and metastasis. Frontiers in Chemistry, 6, 135-1-135-20.
DOI Scopus83 WoS75 Europe PMC77
2018 Kourghi, M., De Ieso, M., Nourmohammadi, S., Pei, J., & Yool, A. (2018). Identification of loop D domain amino acids in the human Aquaporin-1 channel involved in activation of the ionic conductance and inhibition by AqB011. Frontiers in Chemistry, 6(APR), 142-1-142-12.
DOI Scopus19 WoS19 Europe PMC18
2017 Kourghi, M., Nourmohammadi, S., Pei, J., Qiu, J., McGaughey, S., Tyerman, S., . . . Yool, A. (2017). Divalent cations regulate the ion conductance properties of diverse classes of aquaporins. International Journal of Molecular Sciences, 18(11), 2323-1-2323-19.
DOI Scopus63 WoS62 Europe PMC50
2017 Zhou, C., Yool, A., & Byard, R. (2017). Armanni–Ebstein Lesions in Terminal Hyperglycemia. Journal of Forensic Sciences, 62(4), 921-925.
DOI Scopus15 WoS14 Europe PMC8
2017 Zhou, C., Yool, A., & Byard, R. (2017). The Etiology of Basal Vacuolizations in Renal Tubular Epithelial Cells Evaluated in an Isolated Perfused Kidney Model. Journal of Forensic Sciences, 62(4), 915-920.
DOI Scopus6 WoS5 Europe PMC3
2017 Tomita, Y., Dorward, H., Yool, A. J., Smith, E., Townsend, A. R., Price, T. J., & Hardingham, J. E. (2017). Role of aquaporin 1 signalling in cancer development and progression. International Journal of Molecular Sciences, 18(2), 299-1-299-17.
DOI Scopus95 WoS89 Europe PMC78
2017 Zhou, C., Yool, A., & Byard, R. (2017). Basal vacuolization in renal tubular epithelial cells at autopsy and their relation to ketoacidosis. Journal of Forensic Sciences, 62(3), 681-685.
DOI Scopus13 WoS14 Europe PMC11
2017 Zhou, C., Yool, A. J., & Byard, R. W. (2017). An Isolated Perfused Rat Kidney Model for the Evaluation of the Effect of Glucose on Renal Tubular Epithelial Morphology. Journal of Forensic Sciences, 62(1), 5 pages.
DOI Scopus3 WoS3 Europe PMC2
2017 Byrt, C., Zhao, M., Kourghi, M., Bose, J., Henderson, S., Qiu, J., . . . Tyerman, S. (2017). Non-selective cation channel activity of aquaporin AtPIP2;1 regulated by Ca²⁺ and pH. Plant, Cell and Environment, 40(6), 802-815.
DOI Scopus177 WoS158 Europe PMC131
2016 Bajic, J., Eden, G., Lampton, L., Cheah, K., Lymn, K., Pei, J., . . . Howarth, G. (2016). Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World Journal of Gastroenterology, 22(37), 8322-8333.
DOI Scopus28 WoS24 Europe PMC17
2016 Dorward, H., Du, A., Bruhn, M., Wrin, J., Pei, J., Evdokiou, A., . . . Hardingham, J. (2016). Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro. Journal of Experimental & Clinical Cancer Research, 35(1), 36-1-36-9.
DOI Scopus69 WoS65 Europe PMC58
2016 Pei, J., Kourghi, M., De Ieso, M., Campbell, E., Dorward, H., Hardingham, J., & Yool, A. (2016). Differential inhibition of water and ion channel activities of mammalian aquaporin-1 by two structurally related bacopaside compounds derived from the medicinal plant bacopa monnieri. Molecular Pharmacology, 90(4), 496-507.
DOI Scopus63 WoS61 Europe PMC47
2016 Kourghi, M., Pei, J., De Ieso, M., Flynn, G., & Yool, A. (2016). Bumetanide derivatives AqB007 and AqB011 selectively block the aquaporin-1 ion channel conductance and slow cancer cell migration. Molecular Pharmacology, 89(1), 133-140.
DOI Scopus62 WoS60 Europe PMC57
2015 Zhou, C., Moore, L., Yool, A., Jaunzems, A., & Byard, R. (2015). Renal Tubular Epithelial Vacuoles-A Marker for Both Hyperlipidemia and Ketoacidosis at Autopsy. Journal of Forensic Sciences, 60(3), 638-641.
DOI Scopus14 WoS12 Europe PMC9
2015 Saint, D., Horton, D., Yool, A., & Elliott, A. (2015). A progressive assessment strategy improves student learning and perceived course quality in undergraduate physiology. Advances in Physiology Education, 39(3), 218-222.
DOI Scopus5 WoS5 Europe PMC1
2014 Fabrick, J., Pei, J., Hull, J., & Yool, A. (2014). Molecular and functional characterization of multiple aquaporin water channel proteins from the western tarnished plant bug, Lygus hesperus. Insect Biochemistry and Molecular Biology, 45(1), 125-140.
DOI Scopus30 WoS30 Europe PMC27
2014 Zhou, C., Bright, F., Winskog, C., Yool, A., & Byard, R. (2014). Lethal hypothermia in an animal model, not associated with basal renal epithelial vacuolization. Journal of Forensic and Legal Medicine, 21, 14-16.
DOI Scopus13 WoS9 Europe PMC8
2013 Zhou, C., Yool, A., & Byard, R. (2013). Renal cortical pallor - a useful macroscopic marker for metabolic derangements at autopsy. Journal of Forensic Sciences, 58(3), 693-696.
DOI Scopus5 WoS5 Europe PMC2
2013 Zhou, C., Gilbert, J., Yool, A., & Byard, R. (2013). Basal epithelial formalin pigment deposition in the kidneys - A useful marker for ketoacidosis at autopsy. Journal of Forensic and Legal Medicine, 20(4), 305-307.
DOI Scopus20 WoS17 Europe PMC13
2013 Zhou, C., Yool, A., Nolan, J., & Byard, R. (2013). Armanni–Ebstein lesions: A need for clarification. Journal of Forensic Sciences, 58(SUPPL. 1), S94-S98.
DOI Scopus47 WoS42 Europe PMC30
2013 Yool, A., Morelle, J., Cnops, Y., Verbavatz, J., Campbell, E., Spencer, E., . . . Devuyst, O. (2013). AqF026 is a pharmacologic agonist of the water channel aquaporin-1. Journal of the American Society of Nephrology, 24(7), 1045-1052.
DOI Scopus60 WoS55 Europe PMC48
2012 Yool, A., & Campbell, E. (2012). Structure, function and translational relevance of aquaporin dual water and ion channels. Molecular Aspects of Medicine, 33(5-6), 553-561.
DOI Scopus83 WoS73 Europe PMC67
2012 Baetz, N., Stamer, W., & Yool, A. (2012). Stimulation of Aquaporin-Mediated Fluid Transport by Cyclic GMP in Human Retinal Pigment Epithelium In Vitro. Investigative Ophthalmology & Visual Science, 53(4), 2127-2132.
DOI Scopus12 WoS9 Europe PMC10
2012 Campbell, E., Birdsell, D., & Yool, A. (2012). The activity of human aquaporin 1 as a cGMP-gated cation channel is regulated by tyrosine phosphorylation in the carboxyl-terminal domain. Molecular Pharmacology, 81(1), 97-105.
DOI Scopus50 WoS48 Europe PMC42
2012 Yool, A. J., & Campbell, E. M. (2012). Structure, function and translational relevance of aquaporin dual water and ion channels.. Mol Aspects Med, 33(5), 443-561.
2012 Byard, R. W., Zhou, C., Yool, A. J., Parai, J. L., & Milroy, C. M. (2012). Armanni-Ebstein Change or Basal Tubular Vacuolization?. Academic Forensic Pathology, 2(3), 304.
DOI
2011 Vandenberg, R., Handford, C., Campbell, E., Ryan, R., & Yool, A. (2011). Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. Biochemical Journal, 439(2), 333-340.
DOI Scopus17 WoS17 Europe PMC17
2011 Oliva Jr, A., Kang, Y., Truettner, J., Sanchez-Molano, J., Furones, C., Yool, A., & Atkins, C. (2011). Fluid-percussion brain injury induces changes in aquaporin channel expression. Neuroscience, 180, 272-279.
DOI Scopus25 WoS24 Europe PMC22
2011 Matthew, L., Campbell, E., Yool, A., & Fabrick, J. (2011). Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci. Insect Biochemistry and Molecular Biology, 41(3), 178-190.
DOI Scopus47 WoS45 Europe PMC40
2010 Yool, A., Brown, E., & Flynn, G. (2010). Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clinical and Experimental Pharmacology and Physiology, 37(4), 403-409.
DOI Scopus70 WoS65 Europe PMC56
2010 Devuyst, O., & Yool, A. (2010). Aquaporin-1: New developments and perspectives for peritoneal dialysis. Peritoneal Dialysis International, 30(2), 135-141.
DOI Scopus25 WoS25 Europe PMC14
2009 Migliati, E., Meurice, N., Dubois, P., Fang, J., Somasekharan, S., Spencer, E., . . . Yool, A. (2009). Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Molecular Pharmacology, 76(1), 105-112.
DOI Scopus152 WoS141 Europe PMC124
2009 Baetz, N., Hoffman, E., Yool, A., & Stamer, W. (2009). Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Experimental Eye Research, 89(1), 95-100.
DOI Scopus39 WoS33 Europe PMC35
2009 Yool, A. J., Brown, E. A., & Flynn, G. A. (2009). Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clin Exp Pharmacol Physiol, 37(4), 403-409.
DOI
2008 Falk, T., Xie, J. Y., Zhang, S., Kennedy, J., Bennett, J., Yool, A. J., & Sherman, S. J. (2008). Over-expression of the potassium channel Kir2.3 using the dopamine-1 receptor promoter selectively inhibits striatal neurons. Neuroscience, 155(1), 114-127.
DOI Scopus13 WoS14 Europe PMC11
2007 Yool, A. (2007). Functional domains of aquaporin-1: Keys to physiology and targets for drug discovery. Current Pharmaceutical Design, 13(31), 3212-3221.
DOI Scopus46 WoS41 Europe PMC35
2007 Yool, A. (2007). Aquaporins: Multiple roles in the central nervous system. Neuroscientist, 13(5), 470-485.
DOI Scopus89 WoS81 Europe PMC63
2006 Boassa, D., Stamer, W., & Yool, A. (2006). Ion channel function of aquaporin-1 natively expressed in choroid plexus. Journal of Neuroscience, 26(30), 7811-7819.
DOI Scopus93 WoS88 Europe PMC80
2006 Yu, J., Yool, A., Schulten, K., & Tajkhorshid, E. (2006). Mechanism of gating and ion conductivity of a possible tetrameric pore in Aquaporin-1. Structure, 14(9), 1411-1423.
DOI Scopus147 WoS140 Europe PMC113
2006 Yool, A. (2006). Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain. Gene Expression, 13(6), 329-337.
DOI Scopus8 WoS7 Europe PMC7
2005 Boassa, D., & Yool, A. (2005). Physiological roles of aquaporins in the choroid plexus. Current Topics in Developmental Biology, 67, 181-206.
DOI Scopus35 WoS33 Europe PMC31
2004 Yool, A., & Stamer, W. (2004). Novel roles for aquaporins as gated ion channels. Advances in Molecular and Cell Biology, 32, 351-379.
DOI Scopus6
2004 Yanochko, G., & Yool, A. (2004). Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes. Biophysical Journal, 86(3), 1470-1478.
DOI Scopus18 WoS18 Europe PMC19
2003 Falk, T., Kilani, R., Strazdas, L., Borders, R., Steidl, J., Yool, A., & Sherman, S. (2003). Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvß1.1 subunit. Neuroscience, 120(2), 387-404.
DOI Scopus16 WoS16 Europe PMC16
2003 Boassa, D., & Yool, A. (2003). Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation. BMC Physiology, 3(Article 1), 1-13.
DOI Scopus38 Europe PMC33
2002 Yool, A., & Weinstein, A. (2002). New roles for old holes: Ion channel function in aquaporin-1. Physiology, 17(2), 68-72.
DOI Scopus103 WoS97 Europe PMC78
2002 Anthony, T., Fujino, H., Pierce, K., Yool, A., & Regan, J. (2002). Differential regulation of Ca²⁺-dependent Cl⁻ currents by FP prostanoid receptor isoforms in Xenopus oocytes. Biochemical Pharmacology, 63(10), 1797-1806.
DOI Scopus6 WoS5 Europe PMC4
2002 Yool, A., Brokl, O., Pannabecker, T., Dantzler, W., & Stamer, W. (2002). Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line. BMC Physiology, 2(1), 1-8.
DOI Scopus65 Europe PMC61
2002 Yanochko, G., & Yool, A. (2002). Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain. Journal of Neuroscience, 22(7), 2530-2540.
DOI Scopus64 WoS63 Europe PMC50
2002 Boassa, D., & Yool, A. (2002). A fascinating tail: cGMP activation of aquaporin-1 ion channels. Trends in Pharmacological Sciences, 23(12), 558-562.
DOI Scopus48 WoS43 Europe PMC38
2001 Steidl, J., & Yool, A. (2001). Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds. Biophysical Journal, 81(5), 2606-2613.
DOI Scopus10 WoS10 Europe PMC7
2001 Falk, T., Strazdas, L., Borders, R., Kilani, R., Yool, A., & Sherman, S. (2001). A herpes simplex viral vector expressing green fluorescent protein can be used to visualize morphological changes in high-density neuronal culture. Electronic Journal of Biotechnology, 4(1), 33-45.
Scopus2
2001 Falk, T., Kilani, R., Yool, A., & Sherman, S. (2001). Viral vector-mediated expression of K+ channels regulates electrical excitability in skeletal muscle. Gene Therapy, 8(18), 1372-1379.
DOI Scopus10 WoS12 Europe PMC9
2000 Muller, Y. L., Reitstetter, R., & Yool, A. J. (2000). Antisense knockdown of calcium-dependent K+ channels in developing cerebellar Purkinje neurons. Developmental Brain Research, 120(2), 135-140.
DOI Scopus8 WoS8 Europe PMC7
2000 Anthony, T. L., Brooks, H. L., Boassa, D., Leonov, S., Yanochko, G. M., Regan, J. W., & Yool, A. J. (2000). Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. Molecular Pharmacology, 57(3), 576-588.
DOI Scopus163 WoS153 Europe PMC125
2000 Brooks, H. L., Regan, J. W., & Yool, A. J. (2000). Inhibition of aquaporin-1 water permeability by tetraethylammonium: Involvement of the loop E pore region. Molecular Pharmacology, 57(5), 1021-1026.
DOI Scopus130 WoS109 Europe PMC81
1999 Falk, T., Garver, W. S., Erickson, R. P., Wilson, J. M., & Yool, A. J. (1999). Expression of Niemann-Pick type C transcript in rodent cerebellum in vivo and in vitro. Brain Research, 839(1), 49-57.
DOI Scopus21 WoS20 Europe PMC16
1999 Falk, T., Muller, Y. L., & Yool, A. J. (1999). Differential expression of three classes of voltage-gated Ca2+ channels during maturation of the rat cerebellum in vitro. Developmental Brain Research, 115(2), 161-170.
DOI Scopus13 WoS12 Europe PMC8
1999 Steidl, J. V., & Yool, A. J. (1999). Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor. Molecular Pharmacology, 55(5), 812-820.
DOI Scopus73 WoS70 Europe PMC57
1998 Muller, Y. L., & Yool, A. J. (1998). Increased calcium-dependent K+ channel activity contributes to the maturation of cellular firing patterns in developing cerebellar Purkinje neurons. Developmental Brain Research, 108(1-2), 193-203.
DOI Scopus20 WoS17 Europe PMC16
1998 Reitstetter, R., & Yool, A. J. (1998). Morphological consequences of altered calcium-dependent transmembrane signaling on the development of cultured cerebellar Purkinje neurons. Developmental Brain Research, 107(1), 165-167.
DOI Scopus10 WoS9 Europe PMC8
1998 Li Muller, Y., Reitstetter, R., & Yool, A. J. (1998). Regulation of Ca2+ -dependent K+ channel expression in rat cerebellum during postnatal development. Journal of Neuroscience, 18(1), 16-25.
DOI Scopus51 WoS48 Europe PMC42
1998 Jacquin, T. D., Yool, A., Benoit, E., Spitzer, N. C., & Moody, W. J. (1998). Firing and wiring of excitable cells during maturation: the rationale for rhythm. M S-MEDECINE SCIENCES, 14(1), 63-71.
DOI WoS1
1998 Sutherland, V., Sutherland, G., Tucker, V. A., Lynch, R., & Yool, A. (1998). Glucose sensing by neurons isolated from the hypothalamus. FASEB Journal, 12(5), A747.
1998 Yool, A., Benoît, E., Spitzer, N. C., & Moody, W. J. (1998). Petites cellules excitables deviendront grandes : le rythme pour la raison. Medecine/Sciences, 14(1), 63-71.
DOI Scopus1
1997 Agre, P., Lee, M. D., Devidas, S., Guggino, W. B., Sasaki, S., Uchida, S., . . . Yool, A. J. (1997). Aquaporins and ion conductance. Science, 275(5305), 1490-1492.
DOI Scopus87 WoS1 Europe PMC18
1996 Pierce, K., Yool, A., Moyer, P., Gil, D., Woodward, D., & Regan, J. (1996). Cloning of a novel isoform of the sheep FP prostaglandin receptor. Proceedings of the Western Pharmacology Society, 39, 104.
1996 Steidl, J. V., & Yool, A. J. (1996). Molecular mechanisms of action of a class III antiarrhythmic. FASEB Journal, 10(3), A32.
1996 Yool, A. J., Stamer, W. D., & Regan, J. W. (1996). Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. Science, 273(5279), 1216-1218.
DOI Scopus161 WoS159 Europe PMC118
1996 Yool, A. J., & Schwarz, T. L. (1996). Anomalous mole fraction effect induced by mutation of the H5 pore region in the Shaker K+ channel. Biophysical Journal, 71(5), 2467-2472.
DOI Scopus10 WoS10 Europe PMC7
1995 Graves, P. E., Pierce, K. L., Bailey, T. J., Rueda, B. R., Gil, D. W., Woodward, D. F., . . . Regan, J. W. (1995). Cloning of a receptor for prostaglandin F2α from the ovine corpus luteum. Endocrinology, 136(8), 3430-3436.
DOI Scopus66 Europe PMC37
1995 Yool, A. J., & Schwarz, T. L. (1995). Interactions of the H5 pore region and hydroxylamine with N-type inactivation in the Shaker K+ channel. Biophysical Journal, 68(2), 448-458.
DOI Scopus15 WoS16 Europe PMC12
1995 GRAVES, P. E., PIERCE, K. L., BAILEY, T. J., RUEDA, B. R., GIL, D. W., WOODWARD, D. F., . . . REGAN, J. W. (1995). CLONING OF A RECEPTOR FOR PROSTAGLANDIN-F2-ALPHA FROM THE OVINE CORPUS-LUTEUM. ENDOCRINOLOGY, 136(8), 3430-3436.
DOI WoS62
1994 Yool, A. J. (1994). Block of the inactivating potassium channel by clofilium and hydroxylamine depends on the sequence of the pore region. Molecular Pharmacology, 46(5), 970-976.
DOI Scopus8 WoS8 Europe PMC7
1992 SCHWARZ, T. L., & YOOL, A. J. (1992). THE MOLECULAR-BIOLOGY OF POTASSIUM CHANNELS AND MUTATIONS THAT ALTER THE SELECTIVITY OF THE PORE. NEUROTOX 91, 165-177.
1992 Yool, A. J., Krieger, R. M., & Gruol, D. L. (1992). Multiple ionic mechanisms are activated by the potent agonist quisqualate in cultured cerebellar Purkinje neurons. Brain Research, 573(1), 83-94.
DOI Scopus13 WoS15 Europe PMC12
1992 Gruol, D. L., Deal, C. R., & Yool, A. J. (1992). Developmental changes in calcium conductances contribute to the physiological maturation of cerebellar purkinje neurons in culture. Journal of Neuroscience, 12(7), 2838-2848.
DOI Scopus53 WoS56 Europe PMC48
1991 Yool, A. J., & Schwarz, T. L. (1991). Alteration of ionic selectivity of a K+ channel by mutation of the H5 region. Nature, 349(6311), 700-704.
DOI Scopus360 WoS376 Europe PMC275
1991 Gruol, D. L., Jacquin, T., & Yool, A. J. (1991). Single-channel K+ currents recorded from the somatic and dendritic regions of cerebellar purkinje neurons in culture. Journal of Neuroscience, 11(4), 1002-1015.
DOI Scopus49 WoS52 Europe PMC41
1990 Van Gelder, R. N., Von Zastrow, M. E., Yool, A., Dement, W. C., Barchas, J. D., & Eberwine, J. H. (1990). Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proceedings of the National Academy of Sciences of the United States of America, 87(5), 1663-1667.
DOI Scopus1072 WoS940 Europe PMC820
1989 Gruol, D. L., Dionne, V. E., & Yool, A. J. (1989). Multiple voltage-sensitive K+ channels regulate dendritic excitability in cerebellar Purkinje neurons. Neuroscience Letters, 97(1-2), 97-102.
DOI Scopus13 WoS18 Europe PMC12
1989 Joels, M., Yool, A. J., & Gruol, D. L. (1989). Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured Purkinje neurons. Proceedings of the National Academy of Sciences of the United States of America, 86(9), 3404-3408.
DOI Scopus30 WoS32 Europe PMC18
1988 Yool, A. J., Dionne, V. E., & Gruol, D. L. (1988). Developmental changes in K+-selective channel activity during differentiation of the Purkinje neuron in culture. Journal of Neuroscience, 8(6), 1971-1980.
DOI Scopus49 WoS62 Europe PMC49
1988 Yool, A. J., Gruol, D. L., & Dionne, V. E. (1988). Voltage-sensitive K+ channels contribute to dendritic excitability in cerebellar Purkinje neurons.. Symposia in Neuroscience, 6, 57-68.
1987 Yool, A. J., & Gruol, D. L. (1987). Development of spontaneous and glutamate-evoked activity is altered by chronic ethanol in cultured cerebellar Purkinje neurons. Brain Research, 420(2), 205-219.
DOI Scopus27 WoS30 Europe PMC24
1986 YOOL, A. J., GRAU, S. M., HADFIELD, M. G., JENSEN, R. A., MARKELL, D. A., & MORSE, D. E. (1986). EXCESS POTASSIUM INDUCES LARVAL METAMORPHOSIS IN 4 MARINE INVERTEBRATE SPECIES. BIOLOGICAL BULLETIN, 170(2), 255-266.
DOI WoS148
1984 BALOUN, A. J., & MORSE, D. E. (1984). IONIC CONTROL OF SETTLEMENT AND METAMORPHOSIS IN LARVAL HALIOTIS-RUFESCENS (GASTROPODA). BIOLOGICAL BULLETIN, 167(1), 124-138.
DOI WoS136
1980 Morse, D. E., Duncan, H., Hooker, N., Baloun, A., & Young, G. (1980). GABA induces behavioral and developmental metamorphosis in planktonic molluscan larvae. Fed Proc, 39(14), 3237-3241.

Year Citation
2016 Pei, J., Ameliorate, J., Kourghi, M., De Ieso, M., & Yool, A. (2016). Drug Discovery and Therapeutic Targets for Pharmacological Modulators of Aquaporin Channels. In G. Soveral, S. Nielsen, & A. Casini (Eds.), Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery (pp. 273-296). Boca Raton, FL: CRC Press.
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2008 Stamer, W., Baetz, N., & Yool, A. (2008). Ocular aquaporins and aqueous humor dynamics. In The Eye's Aqueous Humor (Vol. 62, 2 ed., pp. 47-70). San Diego, California: Elsevier.
DOI Scopus8 WoS7

Year Citation
2021 Khan, S., Yool, A., & Ricciardelli, C. (2021). EXPRESSION OF AQUAPORINS IN HUMAN ENDOMETRIAL CANCER: IDENTIFICATION AND REGULATION BY OVARIAN HORMONES IN CARCINOGENESIS OF ENDOMETRIAL CANCER. In INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 31 (pp. A75). BMJ PUBLISHING GROUP.
DOI
2020 Montiel, V., Bella, R., Michel, L., Robinson, E., Jonas, J. C., Michel, T., . . . Balligand, J. L. (2020). Inhibition of the water channel aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. In EUROPEAN HEART JOURNAL Vol. 41 (pp. 3665). ELECTR NETWORK: OXFORD UNIV PRESS.
2015 Tomita, Y., Dorward, H., Wrin, J., Vary, R. J., De Ieso, M. L., Yool, A. J., . . . Hardingham, J. E. (2015). The effect of aquaporin-5 knockdown on HT29 colon cancer cell proliferation and migration. In ANNALS OF ONCOLOGY Vol. 26 (pp. 4). Singapore, SINGAPORE: OXFORD UNIV PRESS.
2004 Migliati, E. R., Ritter, L., & Yool, A. J. (2004). A strategy for drug discovery for cerebral oedema after stroke. In JOURNAL OF NEUROLOGY Vol. 251 (pp. 58). Barcelona, SPAIN: DR DIETRICH STEINKOPFF VERLAG.
2004 Falk, T., Erbe, E. L., Yool, A. J., & Shermann, S. J. (2004). Neurochemical and electrophysiological characterization of cultured rat striatal neurons as a model system for gene therapy.. In BIOPHYSICAL JOURNAL Vol. 86 (pp. 270A). Baltimore, MD: BIOPHYSICAL SOCIETY.
2003 Falk, T., Kumar, A., Yool, A. J., & Carnevale, N. T. (2003). Modeling overexpression of different K<SUP>+</SUP> channels in myotubes. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 420A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Birdsell, D. N., & Yool, A. J. (2003). Regulation of cGMP-gated conductance and water permeability of Aqp1 channels by the carboxyl terminal domain.. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 400A-401A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Kruer, M. C., Erbe, E. L., Yool, A. J., & Sherman, S. J. (2003). Changes in the expression of EF-hand calcium binding proteins in rat fetal hippocampal neurons treated with basic fibroblast growth factor and neurotrophin-3.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 51 (pp. S110). CARMEL, CALIFORNIA: B C DECKER INC.
2002 Boassa, D., & Yool, A. J. (2002). Contribution of single amino acids in the carboxyl terminal domain of Aquaporin-1 channels to cGMP-dependent activation. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 275A). BIOPHYSICAL SOCIETY.
2002 Yool, A. J. (2002). Block by divalent cations of the cyclic-GMP-gated ionic conductance in human Aquaporin-1 channels. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 275A). BIOPHYSICAL SOCIETY.
WoS1
2002 Birdsell, D. N., & Yool, A. J. (2002). Voltage dependence of tea block of osmotic water permeability in Aquaporin 1 channels. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 274A-275A). BIOPHYSICAL SOCIETY.
2001 Yool, A. J., & Boassa, D. (2001). Cyclic-GMP-dependent activation of Aquaporin-1 ion channels.. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 102A). BIOPHYSICAL SOCIETY.
2001 Boassa, D., & Yool, A. (2001). Voltage-sensitive rate of activation of aquaporin-1 channels by cGMP.. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 633A). BIOPHYSICAL SOCIETY.
2001 Falk, T., Kilani, R. K., Yool, A. J., & Sherman, S. J. (2001). Viral-vector-mediated expression of K<SUP>+</SUP> channels regulates electrical excitability in skeletal muscle. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 648A). BIOPHYSICAL SOCIETY.
WoS1
2001 Yanochko, G. M., & Yool, A. J. (2001). Cation permeability and divalent cation block of big brain channels. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 204A). BIOPHYSICAL SOCIETY.
2000 Anthony, T. L., Pujino, H., Pierce, K. L., Yool, A. J., & Regan, J. W. (2000). Differential activation of Ca<SUP>2+</SUP>-dependent Cl<SUP>-</SUP> currents by FP prostanoid receptor isoforms in <i>Xenopus</i> oocytes.. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 41 (pp. S250). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
2000 Yanochko, G. M., Vaillancourt, R. R., Regan, J. W., & Yool, A. J. (2000). The MIP-related channel, big brain is regulated by tyrosine phosphorylation in Xenopus oocytes.. In FASEB JOURNAL Vol. 14 (pp. A344). FEDERATION AMER SOC EXP BIOL.
2000 Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In FASEB JOURNAL Vol. 14 (pp. A71). FEDERATION AMER SOC EXP BIOL.
2000 Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 183A). LIPPINCOTT WILLIAMS & WILKINS.
2000 Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (2000). Expression of a potassium channel-reporter gene fusion protein in cultured rat skeletal myocytes.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 87A). LIPPINCOTT WILLIAMS & WILKINS.
2000 Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 77A). LIPPINCOTT WILLIAMS & WILKINS.
2000 Yool, A. J., Boassa, D., Anthony, T. L., & Regan, J. W. (2000). Mechanisms of activation of aquaporin-1 ion channel function. In FASEB JOURNAL Vol. 14 (pp. A344). FEDERATION AMER SOC EXP BIOL.
1999 Brooks, H. L., Regan, J. W., & Yool, A. J. (1999). Inhibition of aquaporin-1 water permeability by TEA.. In FASEB JOURNAL Vol. 13 (pp. A394). FEDERATION AMER SOC EXP BIOL.
WoS3
1999 Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel -reporter gene fusion protein in cultured hippocampal neurons. In Journal of Investigative Medicine Vol. 47 (pp. 34). SLACK INC.
1999 Kilani, R. K., Faik, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel-reporter gene fusion protein in cultured hippocampal neurons.. In FASEB JOURNAL Vol. 13 (pp. A472). FEDERATION AMER SOC EXP BIOL.
1999 Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel-reporter gene fusion protein in cultured hippocampal neurons.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 47 (pp. 196A). SLACK INC.
1999 Sherman, S. J., Falk, T., Borders, R. J., Srazdas, L. A., & Yool, A. J. (1999). Viral vector-mediated trans-gene expression of an antisense sequence targeting knockdown of the β<sub>1.1</sub>-subunit of the K<sub>V</sub>1 voltage-gated potassium channels in cultured hippocampal neurons.. In EPILEPSIA Vol. 40 (pp. 11). LIPPINCOTT WILLIAMS & WILKINS.
1999 Sutherland, V., Murphy, S., Yool, A., & Lynch, R. (1999). Bimodal responses of cultured hypothalamic neurons.. In FASEB JOURNAL Vol. 13 (pp. A748). FEDERATION AMER SOC EXP BIOL.
1997 Lynch, R. M., Tucker, V. A., Sutherland, G., & Yool, A. (1997). Mechanisms of glucose sensing by neurons of the hypothalamus.. In FASEB JOURNAL Vol. 11 (pp. 3624). FEDERATION AMER SOC EXP BIOL.
1996 Pierce, K. L., Yool, A. J., Woodward, D. F., Gil, D. W., & Regan, J. W. (1996). Second messenger coupling of two FP prostanoid receptor carboxy terminal isoforms. In MOLECULAR BIOLOGY OF THE CELL Vol. 7 (pp. 3458). AMER SOC CELL BIOLOGY.
1996 Stamer, W. D., Regan, J. W., & Yool, A. J. (1996). Calcium influences water and cation fluxes in Xenopus oocytes expressing aquaporin-1. In MOLECULAR BIOLOGY OF THE CELL Vol. 7 (pp. 1488). AMER SOC CELL BIOLOGY.
1988 GRUOL, D. L., & YOOL, A. J. (1988). IDENTIFICATION OF K+ CHANNEL TYPES MEDIATING SPIKE EVENTS IN CEREBELLAR PURKINJE NEURONS. In BIOPHYSICAL JOURNAL Vol. 53 (pp. A458). BIOPHYSICAL SOCIETY.
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1986 YOOL, A. J., & GRUOL, D. L. (1986). CHRONIC ETHANOL ALTERS THE SPONTANEOUS ACTIVITY OF DEVELOPING PURKINJE NEURONS IN CULTURE. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 10 (pp. 121). WILLIAMS & WILKINS.
1985 YOOL, A. J., & MORSE, D. E. (1985). IONIC CONTROL OF METAMORPHOSIS IN GASTROPOD LARVAE. In AMERICAN ZOOLOGIST Vol. 25 (pp. 287). AMER SOC ZOOLOGISTS.

Year Citation
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). EPV114/# 325 Expression of aquaporins in human endometrial cancer: identification and regulation by ovarian hormones in carcinogenesis of endometrial cancer. Poster session presented at the meeting of International gynaecological cancer society.
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells.. Poster session presented at the meeting of EMBL Australia.
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Metastasis Research Society (OzMRS).
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Physiological society (AuPS) (oral presentation).
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Identification of Aquaporins in human endometrial cancer and regulation by ovarian hormones in carcinogenesis.. Poster session presented at the meeting of The Australian Society for Medical Research National Scientific Conference, Adelaide, Australia..
2020 Nourmohammadi, S., & Yool, A. (2020). (Oral presentation) Discovering New Cancer-linked Ion Channels using a Photoswitchable Lithium Porbe. Poster session presented at the meeting of 3-minutes talk competition, The Institute for Photonics and Advanced Sensing (IPAS). University of Adelaide.
2019 Nourmohammadi, S., Nwe Aung, T., Cui, J., Pei, J., De leso, M., Qu, Z., . . . Yool, A. (2019). (Oral presentation) Systematic dissection of the molecular actions of compounds from traditional medicinal mixtures on the migration, invasion and apoptosis of brain, bowel and breast cancer cells. Poster session presented at the meeting of AuPS/ABS Meeting, Canberra, 2019.
2019 Nourmohammadi, S., Yool, A., & Adelson, D. (2019). (Poster presentation) Natural Compounds as Potential Anti-metastatic Treatments for Brain, Bowel and Breast Cancer. Poster session presented at the meeting of Florey Postgraduate Conference.
2018 Pei, J. V., Heng, S., De Ieso, M., Sylvia, G., Kourghi, M., Abell, A. D., & Yool, A. J. (2018). Real-Time Imaging of Lithium 'Hot-Spots': An Analysis of Ion Conductance in Aquaporin-1 using Novel Photo-Switchable Sensor. Poster session presented at the meeting of BIOPHYSICAL JOURNAL. San Francisco, CA: CELL PRESS.
2018 Nourmohammadi, S., Nwe Aung, T., Yool, A., & Adelson, D. (2018). (Poster presentation) Fractional Deletion of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical for Its Perturbation of The Cell Cycle. Poster session presented at the meeting of Florey Postgraduate Conference.
2018 Nourmohammadi, S., Yool, A., & Adelson, D. (2018). (Poster presentation) Discovery of the Anti-metastasic Activity of a Chinese medicinal herb mixture 'Compound Kushen Injection' and Identification of the Active Components in Brain, Colon and Breast Cancer Cell Lines. Poster session presented at the meeting of Australian Society for Medical Research (ASMR).
2018 Palethorpe, H. M., Tomita, Y., Smith, E., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Bacopaside II reduces endothelial cell migration and angiogenesis in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne.
2018 Smith, E., Palethorpe, H. M., Tomita, Y., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Anti-tumour effects of Bacopaside II on colorectal cancer cells in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne, VIC.
2017 Nourmohammadi, S., Pie, V. J., Kourghi, M., De leso, M. L., Pak, C., Adelson, D. L., & Yool, A. J. (2017). (Oral presentation) Analysis of effective compounds and mechanisms of action of a Chinese traditional herbal medicine (Compound Kushen Injection) on aquaporins involved in cancer cell migration and metastasis.. Poster session presented at the meeting of Gage Ion Channels and Transporters Conference. Canberra, Australia.
2016 Byrt, C. S., Zhao, M., Kourghi, M., Bose, J., Henderson, S. W., Qui, J., . . . Tyerman, S. (2016). Charging up water transport with plant aquaporins permeable to ions. Poster session presented at the meeting of Combio2016. Brisbane, Australia.
2014 Eden, G., Lampton, L., Cheah, K., Lymn, K., Bajic, J., Yool, A., & Howarth, G. (2014). Aqueous rhubarb extract improves ileal mucosal integrity and reduces acute inflammation in a rat model of 5-fluorouracil-induced intestinal mucositis. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Broadbeach, Qld.: Wiley.
DOI
2013 Pei, J., Campbell, E. M., & Yool, A. J. (2013). Inhibition of aquaporin-1 but not aquaporin-4 water permeability by bacopaside I derived from <i>Bacopa monnieri</i>. Poster session presented at the meeting of PLANTA MEDICA. GEORG THIEME VERLAG KG.
2012 Klebe, S., Griggs, K., Henderson, D. W., & Yool, A. J. (2012). MODULATION OF AQUAPORIN 1 AS A NOVEL TREATMENT STRATEGY FOR MALIGNANT MESOTHELIOMA. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. Adelaide, AUSTRALIA: ELSEVIER SCIENCE INC.
DATE CURRENT GRANTS  Investigators Funding Agency
2022-2024 Investigation the influence of wine macromolecules on aquaporin function and implications for taste signalling

AJ Yool

D Espinase Nandorfy

 Australian Wine Research Institute / UoA Collaborative Research Investment Fund
2022-2024

Testing combined therapies as a powerful tool for controlling paediatric Glioblastoma multiforme invasiveness

SA Ramesh

AJ Yool

R Haberberger

 Children's Research Foundation Ch 7, Australia
2022-2023

Developing novel therapeutic candidates for limiting invasive capabilities of Glioblastoma multiforme cells

SA Ramesh

AJ Yool

RA Davis

NeuroSurgical Research Foundation, Australia

PRIOR FUNDING

Date Title Investigators Funding Agency
2019-2021 Fundamental roles of Aquaporin-1 channels in cellular migration and morphology (DP190101745) AJ Yool and S Ramesh Australian Research Council (ARC)
2019-2021 Channels for improved crop salt and water stress tolerance (DP190102725) C Byrt, S Tyerman, AJ Yool, F Chaumont and M Tester Australian Research Council (ARC)
2020-2022 Developing an animal-free analysis platform to assess human Aquaporin-1 channels involved in cancer cell migration. S Henderson, AJ Yool, B Martinac Medical Advances Without Animals

2016- 2018

 Properties enabling rapid cell migration by aquaporin-1 channel expression  (DP160104641) Yool

Australian Research Council (ARC)
2015 Characterisation of aquaporin-1 (AQP1) ion channel activity in migrating cancer cells using a novel photoswitchable fluorescent probe Yool Institute for Photonics & Advanced Sensing
2011  Aquaporin physiology and drug discovery Yool Adelaide Centre for Neuroscience Research
2010 Role of Aquaporins in mesothelioma Klebe,Yool Flinders Medical Research Foundation
2010 Cloning the Neoparameoba aquaporin channel as a target for parasite control in finfish Cook, Yool CRC Seafood Research Foundation
2010 Role of the brain water channel aquaporin-4 in development and epilepsy Yool Children’s Research Foundation Channel7
2009 Water and ion channel blocking activity of novel neurological agents Yool Neurotherapeutics, Chicago IL USA
2009 The effects of novel aquaporin 4 channel blockers on reducing post stroke edema Chen, Yool Ramaciotti foundation
2006 - 09 Development of novel blockers of Aquaporin-4 channels with translational relevance to stroke-induced brain edema Yool BIO5 Pilot grant, AZ USA
2004 - 09 Predoctoral Training Program in Neuroscience (NIH T321 007434-07) Yool National Institutes of Health (NIH), USA
2003 - 07

Structural basis of ion channel function in Aquaporin-1 (NIH-R01-GM59986)

 Yool National Institutes of Health (NIH), USA

Current teaching contributions:

Principles of Human Health and Disease (Hlth Sci 1005)

Physiology IIB (Physiol 2520) Systems and Homeostasis

Cellular & Systems Neurobiology (Physiol 3104)

BHMS Year 3 Research Placement Course (Hlth Sci X)

* Research Skills Development, BMS year 3 (Med Stud 3503)

Health Sciences Honours Research (AMS)

Honours Research Skills (AMS)

 

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* current course coordinator

 

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor Novel Monitoring of Membrane Electrical Responses in Glioblastoma Cells Using Voltage-Sensitive Dye BeRST 1 for Invasion Inhibition Research Doctor of Philosophy Doctorate Full Time Ms Shijin Suo
2025 Principal Supervisor Novel Monitoring of Membrane Electrical Responses in Glioblastoma Cells Using Voltage-Sensitive Dye BeRST 1 for Invasion Inhibition Research Doctor of Philosophy Doctorate Full Time Ms Shijin Suo
2022 Principal Supervisor Characterization of Drugs Modulating the Aquaporin Channel Activity to Inhibit Angiogenesis and Metastasis Doctor of Philosophy Doctorate Full Time Ms Kim Kristin Wagner
2022 Principal Supervisor Characterization of Drugs Modulating the Aquaporin Channel Activity to Inhibit Angiogenesis and Metastasis Doctor of Philosophy Doctorate Full Time Ms Kim Kristin Wagner

Date Role Research Topic Program Degree Type Student Load Student Name
2021 - 2023 Principal Supervisor Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels Master of Philosophy (Medical Science) Master Full Time Ms Alanah Varricchio
2020 - 2024 Principal Supervisor Developing Novel Conservative Treatments For Endometrial Cancer By Targeting Aquaporin-1 Doctor of Philosophy Doctorate Full Time Ms Sidra Nawaz Khan
2020 - 2023 Principal Supervisor Discovery of novel aquaporin subtypes in the human brain: Potential relevance of peroxiporins AQP0 and AQP11 to cellular stress and Alzheimer’s Disease Doctor of Philosophy Doctorate Full Time Mr Zein Alabedyn Amro
2018 - 2022 Co-Supervisor Bt toxins: using flies, moths, and oocytes to unravel a complex mode of action Doctor of Philosophy Doctorate Full Time Mr Biko Kahare Muita
2018 - 2023 Principal Supervisor Aquaporins - from Ion Channels to Human Cancers Doctor of Philosophy Doctorate Full Time Mr Saeed Nourmohammadi
2016 - 2022 Principal Supervisor Role of Aquaporin 1 in Diseases and Drug Discovery Doctor of Philosophy Doctorate Full Time Mr Pak Hin Chow
2015 - 2021 Co-Supervisor Evaluation of Anti-Cancer Effect of Synthetic and Plant-based Inhibitors of Aquaporin 1 in Colon Cancer Doctor of Philosophy Doctorate Part Time APrf Yoko Tomita
2015 - 2019 Principal Supervisor Pharmacological Modulation of Cancer Migration and Invasion Through Targeting AQP1 Ion and Water Channel Activity Doctor of Philosophy Doctorate Full Time Michael Lucio De Ieso
2013 - 2017 Co-Supervisor A Clarification of the Aetiology and Pathogenesis of Renal Tubular Epithelial Cell Vacuolization in Diabetic Ketoacidosis Doctor of Philosophy Doctorate Part Time Chong Zhou
2013 - 2018 Principal Supervisor A Comparative Study of Physiological and Modulators of Aquaporin ion Channels in Diverse Phyla Doctor of Philosophy Doctorate Full Time Mohamad Kourghi
2012 - 2014 Co-Supervisor AQUAPORINS: GATEKEEPERS OF OEDEMA IN TRAUMATIC BRAIN INJURY Doctor of Philosophy Doctorate Full Time Dr Joshua Luke Burton
2011 - 2016 Co-Supervisor Evaluation of Indices of Affective State in a Rat Model of Chemotherapy-induced Mucositis Doctor of Philosophy Doctorate Part Time APrf Alexandra Whittaker
2011 - 2017 Principal Supervisor Aquaporin in Cancer Cell Migration: Discovery of New Pharmacological Blockers and a Novel Lithium Sensor Doctor of Philosophy Doctorate Full Time Dr Jinxin Pei
2009 - 2010 Principal Supervisor Towards Gene Therapy for Cystic Fibrosis Airway Disease: Development of a Single-Dose Lentiviral Gene Transfer for Lifetime Airway Expression Doctor of Philosophy Doctorate Part Time Ms Alice Stocker
2008 - 2008 Principal Supervisor Characterisation of a Dominant Negative Androgen Receptor in Prostate Cancer Cells Doctor of Philosophy Doctorate Part Time Dr Margaret Centenera

Date Role Membership Country
2008 - ongoing Member Australian Physiology Society Australia
2007 - ongoing Member Australian Society for Biophysics Australia
2006 - ongoing Member Member of Evelyn McKnight Brain Institute United States
2002 - ongoing Member American Society for Pharmacology and Experimental Therapeutics United States

Date Role Editorial Board Name Institution Country
2020 - ongoing Board Member Associate Editor, Frontiers in Pharmacology Frontiers Switzerland

Date Title Type Institution Country
2019 - 2022 ARC College of Experts member (2019-2022) Grant Assessment Australian Research Council -

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