Professor Andrea Yool

Professor of Physiology

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Andrea is a Professor of Physiology at the University of Adelaide, South Australia, and a member of the Institute for Photonics and Advanced Sensing.

She obtained her PhD in Physiology and Cell Biology from the University of California Santa Barbara, and subsequently worked as a research fellow in Neuropharmacology at Scripps Clinic & Research Foundation in California. After further postdoctoral research in Molecular & Cellular Physiology at Stanford University, she was appointed as an academic staff member in the Dept of Physiology at the University of Arizona, with joint appointments in the Dept of Pharmacology and the Division of Neuroscience. She moved to Australia as Professor and Head of Physiology at the University of Adelaide in 2007.

She has a strong publication record in ion channel and water channel physiology, with more than 100 publications, book chapters and review articles in total. More than 70 papers feature her as first or senior author, including work in top tier journals (Science, Nature and PNAS). She has catalysed excellence in research scholarship having supervised research projects for more than 40 Bachelor and Honours students, and served as principal or co-supervisor to over 60 HDR students, and 5 postdoctoral fellows and MD/PhD research fellows, over her career.

Her goals as director of Aquaporin Physiology and Drug Discovery Program are to define the molecular basis of the dual water and ion channel function of aquaporins (AQPs), to understand the roles of AQPs in physiological systems, and to build a definitive portfolio of AQP antagonist and agonist compounds as tools for basic research and clinical innovation.

My Research
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Research

AQUAPORIN PHYSIOLOGY AND DRUG DISCOVERY RESEARCH PROGRAM

The water channels known as aquaporins (AQPs) are an ancient family found in all the kingdoms of life, from bacteria and plants to invertebrates and vertebrates. They play key roles in water balance and fluid homeostasis, cell volume and motility. The thirteen classes of human AQPs show tissue-specific patterns of expression relevant to health and disease. Our goals are to define the molecular basis of the dual water and ion channel functions of aquaporins, to understand the roles of AQPs in physiological systems, and to build a definitive portfolio of AQP antagonist and agonist compounds as tools for basic research and clinical innovation. Aquaporins are currently being uncovered as essential components of rapid cell migration in normal development, wound healing and cancer metastasis (particularly in aggressive cancers such as glioblastoma and colon cancers). AQPs also are emerging as important components for signal transduction in sensory systems. Our work over the past decade has challenged the original dogma that the archetypal channel AQP1 is rigid and constitutively open. We have shown that AQP1 is regulated by intracellular signals and serves as cGMP-gated ion channel as well as an osmotic water channel. Our focus on AQP pharmacology defined the first library of pharmacological agents in the world, based on arylsulfonamide scaffolds showing differential activities on the ion and the water pores. We are also discovering new pharmacological AQP modulators from traditional Chinese and Indian herbal medicines, identifying the active chemical components and defining their molecular targets of action on AQP gating domains. Our findings could offer exciting opportunities for clinical intervention in cancer metastasis, brain oedema, hydrocephalus, and other fluid transport disorders. Our drug agents are currently being tested in vivo in collaborative projects in Australia, Europe and the USA.

Slide title page An overview of AQP research was covered in a plenary talk by Andrea at the first international Aquaporins Solutions conference in Nov 2020 sponsored by Australian National University, available to Uni Adelaide staff and students for viewing at this OneDrive link (24 min):

New Views of Aquaporins

--CURRENT RESEARCH PROJECTS--

Project 1. Using cell culture, molecular biology, expression systems, imaging, and pharmacological tools to define mechanisms and discover novel drugs for controlling the invasiveness of glioblastoma (brain cancer) cells. (Collaboration with Dr Sunita Ramesh, Flinders University; Prof Rainer Haberberger, UofA; and Dr Rohan Davis, Griffith Uni QLD). Available for Honours and HDR placements in 2025.

Project 2. Exploring the roles of aquaporin channels in the tongue as signal transduction mechanisms in sensory system function. (Collaboration with Damian Espinase Nandorfy and Dr Leigh Francis at the Australian Wine Research Institute, UofA). Available for Honours placements in 2024.

Project 3. Discovering new pharmacological modulators of cell motility in natural products including traditional Chinese medicinal herbs. Available for Honours placements in 2024

Location-- Available research projects will be conducted in the Yool laboratory, Helen Mayo South, level 2, Frome Rd (North Terrace campus).

Special requirements-- None; however Physiology courses (PHYSIOL 2510, 2520, 3104), and a background in first year chemistry, biochemistry or the equivalent are highly recommended.

Appointments

Date	Position	Institution name
2007 - ongoing	Professor of Physiology	University of Adelaide
2004 - 2007	Professor	University of Arizona
1998 - 2004	Associate Professor	University of Arizona
1992 - 1998	Assistant Professor	University of Arizona

Education

Date Institution name Country Title

1980 - 1985 University of California, Santa Barbara United States PhD
Postgraduate Training

Date Title Institution Country

1990 - 1992 Postdoctoral Scholar Stanford University United States

1985 - 1989 Postdoctoral Research Fellow Scripps Research Institute United States
Research Interests

Basic Pharmacology Biochemistry and Cell Biology Cancer Therapy Neurosciences Pharmacology and Pharmaceutical Sciences Proteins and Peptides Cancer Biology and Clinical Oncology Neuroscience, Behaviour and Brain Health Translational Health Outcomes Innovative Therapeutics

Date	Institution name	Country	Title
1980 - 1985	University of California, Santa Barbara	United States	PhD

Date	Title	Institution	Country
1990 - 1992	Postdoctoral Scholar	Stanford University	United States
1985 - 1989	Postdoctoral Research Fellow	Scripps Research Institute	United States

Journals

Year	Citation
2024	Ahmed, J., Ismail, A., Ding, L., Yool, A. J., & Chaumont, F. (2024). A new method to measure aquaporin-facilitated membrane diffusion of hydrogen peroxide and cations in plant suspension cells. Plant, Cell and Environment, 47(2), 527-539. DOI Scopus4
2024	Amro, Z., Collins-Praino, L. E., & Yool, A. J. (2024). Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors. Bioscience Reports, 44(3), 21 pages. DOI Scopus4 Europe PMC3
2024	Nourmohammadi, S., Henderson, S. W., Ramesh, S. A., & Yool, A. J. (2024). Characterization of human aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery. Bioscience reports, 44(8), 20 pages. DOI
2023	Varricchio, A., & Yool, A. J. (2023). Aquaporins and Ion Channels as Dual Targets in the Design of Novel Glioblastoma Therapeutics to Limit Invasiveness. Cancers, 15(3), 849. DOI Scopus1 WoS1 Europe PMC2
2023	Varricchio, A., Khan, S., Price, Z. K., Davis, R. A., Ramesh, S. A., & Yool, A. J. (2023). Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro. Cancers, 15(4), 1-20. DOI Scopus8 WoS4 Europe PMC5
2023	Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15. DOI Scopus3 WoS2 Europe PMC2
2023	Varricchio, A., Yool, A. J., & Ramesh, S. A. (2023). Subtype-specific block of glioblastoma motility through dual inhibition of water and ion flux. Biophysical journal, 122(3S1), 255a-256a. DOI
2023	Amro, Z., Ryan, M., Collins-Praino, L. E., & Yool, A. J. (2023). Unexpected Classes of Aquaporin Channels Detected by Transcriptomic Analysis in Human Brain Are Associated with Both Patient Age and Alzheimer’s Disease Status. Biomedicines, 11(3), 1-19. DOI Scopus5 Europe PMC5
2023	Khan, S., Lokman, N. A., Oehler, M. K., Ricciardelli, C., & Yool, A. J. (2023). Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. Cancers, 15(18), 4507-1-4507-27. DOI
2022	Khan, S., Varricchio, A., Ricciardelli, C., & Yool, A. J. (2022). Invasiveness of endometrial cancer cell lines is potentiated by estradiol and blocked by a traditional medicine Guizhi Fuling at clinically relevant doses.. Frontiers in Oncology, 12, 15 pages. DOI Scopus3 WoS2 Europe PMC2
2022	Salman, M. M., Kitchen, P., Yool, A. J., & Bill, R. M. (2022). Recent breakthroughs and future directions in drugging aquaporins. Trends in Pharmacological Sciences, 43(1), 30-42. DOI Scopus64 WoS47 Europe PMC50
2022	Henderson, S. W., Nourmohammadi, S., Ramesh, S. A., & Yool, A. J. (2022). Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology. Biophysical Reviews, 14(1), 181-198. DOI Scopus12 WoS7 Europe PMC11
2022	Wagner, K., Unger, L., Salman, M. M., Kitchen, P., Bill, R. M., & Yool, A. J. (2022). Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease. International Journal of Molecular Sciences, 23(3), 1388. DOI Scopus63 WoS34 Europe PMC42
2021	Chow, P. H., Cox, C. D., Pei, J. V., Anabaraonye, N., Nourmohammadi, S., Henderson, S. W., . . . Yool, A. J. (2021). Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling.. Frontiers in pharmacology, 12, 1-13. DOI Scopus3 WoS3 Europe PMC4
2021	Tomita, Y., Smith, E., Palethorpe, H. M., Nakhjavani, M., Yeo, K. K. L., Townsend, A. R., . . . Hardingham, J. E. (2021). In vitro synergistic inhibition of HT-29 proliferation and 2H-11 and HUVEC tubulogenesis by bacopaside I and II Is associated with Ca²⁺ flux and loss of plasma membrane integrity. Pharmaceuticals, 14(5), 1-18. DOI Scopus3 WoS2
2021	Nakhjavani, M., Smith, E., Yeo, K., Tomita, Y., Price, T. J., Yool, A., . . . Hardingham, J. E. (2021). Differential antiangiogenic and anticancer activities of the active metabolites of ginsenoside Rg3. Journal of Ginseng Research, 48(2), 10 pages. DOI Scopus2 Europe PMC2
2021	Amro, Z., Yool, A. J., & Collins-Praino, L. E. (2021). The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathies. Brain, behavior, & immunity - health, 14, 100242-1-100242-14. DOI Scopus18 WoS11 Europe PMC14
2021	Varricchio, A., Ramesh, S. A., & Yool, A. J. (2021). Novel ion channel targets and drug delivery tools for controlling glioblastoma cell invasiveness. International Journal of Molecular Sciences, 22(21), 11909-1-11909-22. DOI Scopus9 WoS5 Europe PMC9
2021	Khan, S., Ricciardelli, C., & Yool, A. J. (2021). Targeting aquaporins in novel therapies for male and female breast and reproductive cancers. Cells, 10(2), 1-18. DOI Scopus17 WoS13 Europe PMC12
2021	Tyerman, S. D., McGaughey, S. A., Qiu, J., Yool, A. J., & Byrt, C. S. (2021). Adaptable and multifunctional ion-conducting aquaporins. Annual Review of Plant Biology, 72(1), 1-34. DOI Scopus62 WoS39 Europe PMC32
2020	Chow, P. H., Kourghi, M., Pei, J. V., Nourmohammadi, S., & Yool, A. J. (2020). 5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion. Mol Pharmacol, 98(1), 38-48. DOI Scopus22 WoS16 Europe PMC18
2020	Fabrick, J. A., Yool, A. J., & Spurgeon, D. W. (2020). Insecticidal activity of marigold Tagetes patula plants and foliar extracts against the hemipteran pests, Lygus hesperus and Bemisia tabaci. PLoS ONE, 15(5), 15 pages. DOI Scopus34 WoS18 Europe PMC8
2020	Chow, P. H., Bowen, J., & Yool, A. J. (2020). Combined systematic review and transcriptomic analyses of mammalian aquaporin classes 1 to 10 as biomarkers and prognostic indicators in diverse cancers. Cancers, 12(7), 1-31. DOI Scopus25 WoS18 Europe PMC17
2020	Montiel, V., Bella, R., Michel, L. Y. M., Esfahani, H., De Mulder, D., Robinson, E. L., . . . Balligand, J. -L. (2020). Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Science Translational Medicine, 12(564), 1-16. DOI Scopus44 WoS32 Europe PMC35
2020	Yool, A. J., & Ramesh, S. (2020). Molecular targets for combined therapeutic strategies to limit glioblastoma cell migration and invasion. Frontiers in Pharmacology, 11, 358-1-358-26. DOI Scopus30 WoS25 Europe PMC21
2019	Pei, J. V., Heng, S., De Ieso, M. L., Sylvia, G., Kourghi, M., Nourmohammadi, S., . . . Yool, A. J. (2019). Development of a photoswitchable lithium-sensitive probe to analyze nonselective cation channel activity in migrating cancer cells. Molecular Pharmacology, 95(5), 573-583. DOI Scopus20 WoS15 Europe PMC9
2019	Tomita, Y., Palethorpe, H. M., Smith, E., Nakhjavani, M., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2019). Bumetanide-derived aquaporin 1 inhibitors, AqB013 and AqB050 inhibit tube formation of endothelial cells through induction of apoptosis and impaired migration in vitro. International Journal of Molecular Sciences, 20(8), 1818-1-1818-11. DOI Scopus16 WoS16 Europe PMC15
2019	Nourmohammadi, S., Aung, T. N., Cui, J., Pei, J., De Ieso, M. L., Harata-Lee, Y., . . . Yool, A. J. (2019). Effect of compound kushen injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Frontiers in Oncology, 9(APR), 1-14. DOI Scopus46 WoS38 Europe PMC32
2019	Nakhjavani, M., Palethorpe, H. M., Tomita, Y., Smith, E., Price, T. J., Yool, A. J., . . . Hardingham, J. E. (2019). Stereoselective anti-cancer activities of ginsenoside Rg3 on triple negative breast cancer cell models. Pharmaceuticals, 12(3), 117-1-117-14. DOI Scopus40 WoS29 Europe PMC23
2019	De Ieso, M. L., Pei, J. V., Nourmohammadi, S., Smith, E., Chow, P. H., Kourghi, M., . . . Yool, A. J. (2019). Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration. Scientific Reports, 9(1), 12635-1-12635-17. DOI Scopus33 WoS24 Europe PMC22
2019	Aung, T. N., Nourmohammadi, S., Qu, Z., Harata-Lee, Y., Cui, J., Shen, H. Y., . . . Adelson, D. L. (2019). Fractional deletion of Compound Kushen Injection indicates cytokine signaling pathways are critical for its perturbation of the cell cycle. Scientific Reports, 9(1), 14200-1-14200-16. DOI Scopus10 WoS7 Europe PMC8
2019	Palethorpe, H. M., Smith, E., Tomita, Y., Nakhjavani, M., Yool, A. J., Price, T. J., . . . Hardingham, J. E. (2019). Bacopasides I and II act in synergy to inhibit the growth, migration and invasion of breast cancer cell lines. Molecules, 24(19), 3539-1-3539-16. DOI Scopus29 WoS22 Europe PMC14
2018	Smith, E., Palethorpe, H. M., Tomita, Y., Pei, J., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2018). The purified extract from the medicinal plant Bacopa monnieri, bacopaside II, inhibits growth of colon cancer cells in vitro by inducing cell cycle arrest and apoptosis. Cells, 7(7), 81-1-81-11. DOI Scopus47 WoS36 Europe PMC24
2018	Kourghi, M., Pei, J., De Ieso, M., Nourmohammadi, S., Chow, P., & Yool, A. (2018). Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Clinical and Experimental Pharmacology and Physiology, 45(4), 401-409. DOI Scopus37 WoS31 Europe PMC20
2018	Palethorpe, H., Tomita, Y., Smith, E., Pei, J., Townsend, A., Price, T., . . . Hardingham, J. (2018). The aquaporin 1 inhibitor bacopaside II reduces endothelial cell migration and tubulogenesis and induces apoptosis. International Journal of Molecular Sciences, 19(3), 653-1-653-10. DOI Scopus28 WoS24 Europe PMC17
2018	De Ieso, M., & Yool, A. (2018). Mechanisms of aquaporin-facilitated cancer invasion and metastasis. Frontiers in Chemistry, 6, 135-1-135-20. DOI Scopus76 WoS56 Europe PMC56
2018	Kourghi, M., De Ieso, M., Nourmohammadi, S., Pei, J., & Yool, A. (2018). Identification of loop D domain amino acids in the human Aquaporin-1 channel involved in activation of the ionic conductance and inhibition by AqB011. Frontiers in Chemistry, 6(APR), 142-1-142-12. DOI Scopus18 WoS15 Europe PMC14
2017	Kourghi, M., Nourmohammadi, S., Pei, J., Qiu, J., McGaughey, S., Tyerman, S., . . . Yool, A. (2017). Divalent cations regulate the ion conductance properties of diverse classes of aquaporins. International Journal of Molecular Sciences, 18(11), 2323-1-2323-19. DOI Scopus57 WoS48 Europe PMC33
2017	Zhou, C., Yool, A., & Byard, R. (2017). Armanni–Ebstein Lesions in Terminal Hyperglycemia. Journal of Forensic Sciences, 62(4), 921-925. DOI Scopus14 WoS13 Europe PMC6
2017	Zhou, C., Yool, A., & Byard, R. (2017). The Etiology of Basal Vacuolizations in Renal Tubular Epithelial Cells Evaluated in an Isolated Perfused Kidney Model. Journal of Forensic Sciences, 62(4), 915-920. DOI Scopus6 WoS5
2017	Tomita, Y., Dorward, H., Yool, A. J., Smith, E., Townsend, A. R., Price, T. J., & Hardingham, J. E. (2017). Role of aquaporin 1 signalling in cancer development and progression. International Journal of Molecular Sciences, 18(2), 299-1-299-17. DOI Scopus85 WoS73 Europe PMC56
2017	Zhou, C., Yool, A., & Byard, R. (2017). Basal vacuolization in renal tubular epithelial cells at autopsy and their relation to ketoacidosis. Journal of Forensic Sciences, 62(3), 681-685. DOI Scopus11 WoS12 Europe PMC6
2017	Zhou, C., Yool, A. J., & Byard, R. W. (2017). An Isolated Perfused Rat Kidney Model for the Evaluation of the Effect of Glucose on Renal Tubular Epithelial Morphology. Journal of Forensic Sciences, 62(1), 5 pages. DOI Scopus3 WoS3 Europe PMC2
2017	Byrt, C., Zhao, M., Kourghi, M., Bose, J., Henderson, S., Qiu, J., . . . Tyerman, S. (2017). Non-selective cation channel activity of aquaporin AtPIP2;1 regulated by Ca²⁺ and pH. Plant, Cell and Environment, 40(6), 802-815. DOI Scopus151 WoS124 Europe PMC70
2016	Bajic, J., Eden, G., Lampton, L., Cheah, K., Lymn, K., Pei, J., . . . Howarth, G. (2016). Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World Journal of Gastroenterology, 22(37), 8322-8333. DOI Scopus23 WoS19 Europe PMC12
2016	Dorward, H., Du, A., Bruhn, M., Wrin, J., Pei, J., Evdokiou, A., . . . Hardingham, J. (2016). Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro. Journal of Experimental & Clinical Cancer Research, 35(1), 36-1-36-9. DOI Scopus65 WoS57 Europe PMC48
2016	Pei, J., Kourghi, M., De Ieso, M., Campbell, E., Dorward, H., Hardingham, J., & Yool, A. (2016). Differential inhibition of water and ion channel activities of mammalian aquaporin-1 by two structurally related bacopaside compounds derived from the medicinal plant bacopa monnieri. Molecular Pharmacology, 90(4), 496-507. DOI Scopus52 WoS44 Europe PMC36
2016	Kourghi, M., Pei, J., De Ieso, M., Flynn, G., & Yool, A. (2016). Bumetanide derivatives AqB007 and AqB011 selectively block the aquaporin-1 ion channel conductance and slow cancer cell migration. Molecular Pharmacology, 89(1), 133-140. DOI Scopus54 WoS47 Europe PMC43
2015	Zhou, C., Moore, L., Yool, A., Jaunzems, A., & Byard, R. (2015). Renal Tubular Epithelial Vacuoles-A Marker for Both Hyperlipidemia and Ketoacidosis at Autopsy. Journal of Forensic Sciences, 60(3), 638-641. DOI Scopus13 WoS10 Europe PMC8
2015	Saint, D., Horton, D., Yool, A., & Elliott, A. (2015). A progressive assessment strategy improves student learning and perceived course quality in undergraduate physiology. Advances in Physiology Education, 39(3), 218-222. DOI Scopus4 WoS5 Europe PMC1
2014	Fabrick, J., Pei, J., Hull, J., & Yool, A. (2014). Molecular and functional characterization of multiple aquaporin water channel proteins from the western tarnished plant bug, Lygus hesperus. Insect Biochemistry and Molecular Biology, 45(1), 125-140. DOI Scopus30 WoS28 Europe PMC22
2014	Zhou, C., Bright, F., Winskog, C., Yool, A., & Byard, R. (2014). Lethal hypothermia in an animal model, not associated with basal renal epithelial vacuolization. Journal of Forensic and Legal Medicine, 21, 14-16. DOI Scopus12 WoS9 Europe PMC7
2013	Zhou, C., Yool, A., & Byard, R. (2013). Renal cortical pallor - a useful macroscopic marker for metabolic derangements at autopsy. Journal of Forensic Sciences, 58(3), 693-696. DOI Scopus5 WoS5 Europe PMC2
2013	Zhou, C., Gilbert, J., Yool, A., & Byard, R. (2013). Basal epithelial formalin pigment deposition in the kidneys - A useful marker for ketoacidosis at autopsy. Journal of Forensic and Legal Medicine, 20(4), 305-307. DOI Scopus18 WoS14 Europe PMC8
2013	Zhou, C., Yool, A., Nolan, J., & Byard, R. (2013). Armanni–Ebstein lesions: A need for clarification. Journal of Forensic Sciences, 58(SUPPL. 1), S94-S98. DOI Scopus44 WoS37 Europe PMC24
2013	Yool, A., Morelle, J., Cnops, Y., Verbavatz, J., Campbell, E., Spencer, E., . . . Devuyst, O. (2013). AqF026 is a pharmacologic agonist of the water channel aquaporin-1. Journal of the American Society of Nephrology, 24(7), 1045-1052. DOI Scopus54 WoS42 Europe PMC37
2012	Yool, A., & Campbell, E. (2012). Structure, function and translational relevance of aquaporin dual water and ion channels. Molecular Aspects of Medicine, 33(5-6), 553-561. DOI Scopus77 WoS58 Europe PMC49
2012	Baetz, N., Stamer, W., & Yool, A. (2012). Stimulation of Aquaporin-Mediated Fluid Transport by Cyclic GMP in Human Retinal Pigment Epithelium In Vitro. Investigative Ophthalmology & Visual Science, 53(4), 2127-2132. DOI Scopus11 WoS8 Europe PMC6
2012	Campbell, E., Birdsell, D., & Yool, A. (2012). The activity of human aquaporin 1 as a cGMP-gated cation channel is regulated by tyrosine phosphorylation in the carboxyl-terminal domain. Molecular Pharmacology, 81(1), 97-105. DOI Scopus48 WoS43 Europe PMC37
2012	Yool, A. J., & Campbell, E. M. (2012). Structure, function and translational relevance of aquaporin dual water and ion channels.. Mol Aspects Med, 33(5), 443-561.
2012	Byard, R. W., Zhou, C., Yool, A. J., Parai, J. L., & Milroy, C. M. (2012). Armanni-Ebstein Change or Basal Tubular Vacuolization?. Academic Forensic Pathology, 2(3), 304. DOI
2011	Vandenberg, R., Handford, C., Campbell, E., Ryan, R., & Yool, A. (2011). Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. Biochemical Journal, 439(2), 333-340. DOI Scopus17 WoS17 Europe PMC14
2011	Oliva Jr, A., Kang, Y., Truettner, J., Sanchez-Molano, J., Furones, C., Yool, A., & Atkins, C. (2011). Fluid-percussion brain injury induces changes in aquaporin channel expression. Neuroscience, 180, 272-279. DOI Scopus23 WoS21 Europe PMC19
2011	Matthew, L., Campbell, E., Yool, A., & Fabrick, J. (2011). Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci. Insect Biochemistry and Molecular Biology, 41(3), 178-190. DOI Scopus44 WoS36 Europe PMC30
2010	Yool, A., Brown, E., & Flynn, G. (2010). Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clinical and Experimental Pharmacology and Physiology, 37(4), 403-409. DOI Scopus68 WoS61 Europe PMC46
2010	Devuyst, O., & Yool, A. (2010). Aquaporin-1: New developments and perspectives for peritoneal dialysis. Peritoneal Dialysis International, 30(2), 135-141. DOI Scopus24 WoS24 Europe PMC13
2009	Migliati, E., Meurice, N., Dubois, P., Fang, J., Somasekharan, S., Spencer, E., . . . Yool, A. (2009). Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Molecular Pharmacology, 76(1), 105-112. DOI Scopus139 WoS126 Europe PMC93
2009	Baetz, N., Hoffman, E., Yool, A., & Stamer, W. (2009). Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Experimental Eye Research, 89(1), 95-100. DOI Scopus39 WoS28 Europe PMC29
2009	Yool, A. J., Brown, E. A., & Flynn, G. A. (2009). Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clin Exp Pharmacol Physiol, 37(4), 403-409. DOI
2008	Falk, T., Xie, J. Y., Zhang, S., Kennedy, J., Bennett, J., Yool, A. J., & Sherman, S. J. (2008). Over-expression of the potassium channel Kir2.3 using the dopamine-1 receptor promoter selectively inhibits striatal neurons. Neuroscience, 155(1), 114-127. DOI Scopus12 WoS13 Europe PMC8
2007	Yool, A. (2007). Functional domains of aquaporin-1: Keys to physiology and targets for drug discovery. Current Pharmaceutical Design, 13(31), 3212-3221. DOI Scopus45 WoS41 Europe PMC29
2007	Yool, A. (2007). Aquaporins: Multiple roles in the central nervous system. Neuroscientist, 13(5), 470-485. DOI Scopus86 WoS74 Europe PMC47
2006	Boassa, D., Stamer, W., & Yool, A. (2006). Ion channel function of aquaporin-1 natively expressed in choroid plexus. Journal of Neuroscience, 26(30), 7811-7819. DOI Scopus92 WoS81 Europe PMC69
2006	Yu, J., Yool, A., Schulten, K., & Tajkhorshid, E. (2006). Mechanism of gating and ion conductivity of a possible tetrameric pore in Aquaporin-1. Structure, 14(9), 1411-1423. DOI Scopus143 WoS126 Europe PMC93
2006	Yool, A. (2006). Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain. Gene Expression, 13(6), 329-337. DOI Scopus7 WoS5 Europe PMC7
2005	Boassa, D., & Yool, A. (2005). Physiological roles of aquaporins in the choroid plexus. Current Topics in Developmental Biology, 67, 181-206. DOI Scopus33 WoS33 Europe PMC28
2004	Yool, A., & Stamer, W. (2004). Novel roles for aquaporins as gated ion channels. Advances in Molecular and Cell Biology, 32, 351-379. DOI Scopus6
2004	Yanochko, G., & Yool, A. (2004). Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes. Biophysical Journal, 86(3), 1470-1478. DOI Scopus18 WoS17 Europe PMC18
2003	Falk, T., Kilani, R., Strazdas, L., Borders, R., Steidl, J., Yool, A., & Sherman, S. (2003). Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvß1.1 subunit. Neuroscience, 120(2), 387-404. DOI Scopus16 WoS16 Europe PMC15
2003	Boassa, D., & Yool, A. (2003). Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation. BMC Physiology, 3(Article 1), 1-13. DOI Scopus37 Europe PMC30
2002	Yool, A., & Weinstein, A. (2002). New roles for old holes: Ion channel function in aquaporin-1. Physiology, 17(2), 68-72. DOI Scopus101 WoS91 Europe PMC66
2002	Anthony, T., Fujino, H., Pierce, K., Yool, A., & Regan, J. (2002). Differential regulation of Ca²⁺-dependent Cl⁻ currents by FP prostanoid receptor isoforms in Xenopus oocytes. Biochemical Pharmacology, 63(10), 1797-1806. DOI Scopus5 WoS4 Europe PMC3
2002	Yool, A., Brokl, O., Pannabecker, T., Dantzler, W., & Stamer, W. (2002). Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line. BMC Physiology, 2(1), 1-8. DOI Scopus63 Europe PMC47
2002	Yanochko, G., & Yool, A. (2002). Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain. Journal of Neuroscience, 22(7), 2530-2540. DOI Scopus62 WoS59 Europe PMC41
2002	Boassa, D., & Yool, A. (2002). A fascinating tail: cGMP activation of aquaporin-1 ion channels. Trends in Pharmacological Sciences, 23(12), 558-562. DOI Scopus46 WoS39 Europe PMC32
2001	Steidl, J., & Yool, A. (2001). Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds. Biophysical Journal, 81(5), 2606-2613. DOI Scopus10 WoS10 Europe PMC7
2001	Falk, T., Strazdas, L., Borders, R., Kilani, R., Yool, A., & Sherman, S. (2001). A herpes simplex viral vector expressing green fluorescent protein can be used to visualize morphological changes in high-density neuronal culture. Electronic Journal of Biotechnology, 4(1), 33-45. Scopus2
2001	Falk, T., Kilani, R., Yool, A., & Sherman, S. (2001). Viral vector-mediated expression of K+ channels regulates electrical excitability in skeletal muscle. Gene Therapy, 8(18), 1372-1379. DOI Scopus10 WoS11 Europe PMC8
2000	Muller, Y. L., Reitstetter, R., & Yool, A. J. (2000). Antisense knockdown of calcium-dependent K<sup>+</sup> channels in developing cerebellar Purkinje neurons. Developmental Brain Research, 120(2), 135-140. DOI Scopus8 WoS8 Europe PMC6
2000	Anthony, T. L., Brooks, H. L., Boassa, D., Leonov, S., Yanochko, G. M., Regan, J. W., & Yool, A. J. (2000). Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. Molecular Pharmacology, 57(3), 576-588. DOI Scopus160 WoS144 Europe PMC106
2000	Brooks, H. L., Regan, J. W., & Yool, A. J. (2000). Inhibition of aquaporin-1 water permeability by tetraethylammonium: Involvement of the loop E pore region. Molecular Pharmacology, 57(5), 1021-1026. Scopus126 WoS105 Europe PMC73
1999	Falk, T., Garver, W. S., Erickson, R. P., Wilson, J. M., & Yool, A. J. (1999). Expression of Niemann-Pick type C transcript in rodent cerebellum in vivo and in vitro. Brain Research, 839(1), 49-57. DOI Scopus21 WoS19 Europe PMC16
1999	Falk, T., Muller, Y. L., & Yool, A. J. (1999). Differential expression of three classes of voltage-gated Ca<sup>2+</sup> channels during maturation of the rat cerebellum in vitro. Developmental Brain Research, 115(2), 161-170. DOI Scopus13 WoS12 Europe PMC8
1999	Steidl, J. V., & Yool, A. J. (1999). Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor. Molecular Pharmacology, 55(5), 812-820. Scopus71 WoS67 Europe PMC53
1998	Muller, Y. L., & Yool, A. J. (1998). Increased calcium-dependent K<sup>+</sup> channel activity contributes to the maturation of cellular firing patterns in developing cerebellar Purkinje neurons. Developmental Brain Research, 108(1-2), 193-203. DOI Scopus20 WoS17 Europe PMC13
1998	Reitstetter, R., & Yool, A. J. (1998). Morphological consequences of altered calcium-dependent transmembrane signaling on the development of cultured cerebellar Purkinje neurons. Developmental Brain Research, 107(1), 165-167. DOI Scopus10 WoS9 Europe PMC7
1998	Li Muller, Y., Reitstetter, R., & Yool, A. J. (1998). Regulation of Ca<sup>2+</sup> -dependent K<sup>+</sup> channel expression in rat cerebellum during postnatal development. Journal of Neuroscience, 18(1), 16-25. DOI Scopus51 WoS47 Europe PMC38
1998	Jacquin, T. D., Yool, A., Benoit, E., Spitzer, N. C., & Moody, W. J. (1998). Firing and wiring of excitable cells during maturation: the rationale for rhythm. M S-MEDECINE SCIENCES, 14(1), 63-71. DOI WoS1
1998	Sutherland, V., Sutherland, G., Tucker, V. A., Lynch, R., & Yool, A. (1998). Glucose sensing by neurons isolated from the hypothalamus. FASEB Journal, 12(5), A747.
1998	Yool, A., Benoît, E., Spitzer, N. C., & Moody, W. J. (1998). Petites cellules excitables deviendront grandes : le rythme pour la raison. Medecine/Sciences, 14(1), 63-71. DOI Scopus1
1997	Agre, P., Lee, M. D., Devidas, S., Guggino, W. B., Sasaki, S., Uchida, S., . . . Yool, A. J. (1997). Aquaporins and ion conductance. Science, 275(5305), 1490-1492. DOI Scopus87 WoS1 Europe PMC35
1996	Pierce, K., Yool, A., Moyer, P., Gil, D., Woodward, D., & Regan, J. (1996). Cloning of a novel isoform of the sheep FP prostaglandin receptor. Proceedings of the Western Pharmacology Society, 39, 104.
1996	Steidl, J. V., & Yool, A. J. (1996). Molecular mechanisms of action of a class III antiarrhythmic. FASEB Journal, 10(3), 183.
1996	Yool, A. J., Stamer, W. D., & Regan, J. W. (1996). Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. Science, 273(5279), 1216-1218. DOI Scopus155 WoS147 Europe PMC86
1996	Yool, A. J., & Schwarz, T. L. (1996). Anomalous mole fraction effect induced by mutation of the H5 pore region in the Shaker K<sup>+</sup> channel. Biophysical Journal, 71(5), 2467-2472. DOI Scopus10 WoS10 Europe PMC6
1995	Graves, P. E., Pierce, K. L., Bailey, T. J., Rueda, B. R., Gil, D. W., Woodward, D. F., . . . Regan, J. W. (1995). Cloning of a receptor for prostaglandin F2α from the ovine corpus luteum. Endocrinology, 136(8), 3430-3436. DOI Scopus65 Europe PMC31
1995	Yool, A. J., & Schwarz, T. L. (1995). Interactions of the H5 pore region and hydroxylamine with N-type inactivation in the Shaker K+ channel. Biophysical Journal, 68(2), 448-458. DOI Scopus15 WoS16 Europe PMC10
1995	GRAVES, P. E., PIERCE, K. L., BAILEY, T. J., RUEDA, B. R., GIL, D. W., WOODWARD, D. F., . . . REGAN, J. W. (1995). CLONING OF A RECEPTOR FOR PROSTAGLANDIN-F2-ALPHA FROM THE OVINE CORPUS-LUTEUM. ENDOCRINOLOGY, 136(8), 3430-3436. DOI WoS62
1994	Yool, A. J. (1994). Block of the inactivating potassium channel by clofilium and hydroxylamine depends on the sequence of the pore region. Molecular Pharmacology, 46(5), 970-976. Scopus8 WoS8 Europe PMC6
1992	SCHWARZ, T. L., & YOOL, A. J. (1992). THE MOLECULAR-BIOLOGY OF POTASSIUM CHANNELS AND MUTATIONS THAT ALTER THE SELECTIVITY OF THE PORE. NEUROTOX 91, 165-177.
1992	Yool, A. J., Krieger, R. M., & Gruol, D. L. (1992). Multiple ionic mechanisms are activated by the potent agonist quisqualate in cultured cerebellar Purkinje neurons. Brain Research, 573(1), 83-94. DOI Scopus13 WoS15 Europe PMC11
1992	Gruol, D. L., Deal, C. R., & Yool, A. J. (1992). Developmental changes in calcium conductances contribute to the physiological maturation of cerebellar purkinje neurons in culture. Journal of Neuroscience, 12(7), 2838-2848. DOI Scopus53 WoS56 Europe PMC45
1991	Yool, A. J., & Schwarz, T. L. (1991). Alteration of ionic selectivity of a K<sup>+</sup> channel by mutation of the H5 region. Nature, 349(6311), 700-704. DOI Scopus358 WoS375 Europe PMC228
1991	Gruol, D. L., Jacquin, T., & Yool, A. J. (1991). Single-channel K<sup>+</sup> currents recorded from the somatic and dendritic regions of cerebellar purkinje neurons in culture. Journal of Neuroscience, 11(4), 1002-1015. DOI Scopus49 WoS51 Europe PMC41
1990	Van Gelder, R. N., Von Zastrow, M. E., Yool, A., Dement, W. C., Barchas, J. D., & Eberwine, J. H. (1990). Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proceedings of the National Academy of Sciences of the United States of America, 87(5), 1663-1667. DOI Scopus1057 WoS939 Europe PMC695
1989	Gruol, D. L., Dionne, V. E., & Yool, A. J. (1989). Multiple voltage-sensitive K<sup>+</sup> channels regulate dendritic excitability in cerebellar Purkinje neurons. Neuroscience Letters, 97(1-2), 97-102. DOI Scopus13 WoS17 Europe PMC12
1989	Joels, M., Yool, A. J., & Gruol, D. L. (1989). Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured Purkinje neurons. Proceedings of the National Academy of Sciences of the United States of America, 86(9), 3404-3408. DOI Scopus30 WoS31 Europe PMC17
1988	Yool, A. J., Dionne, V. E., & Gruol, D. L. (1988). Developmental changes in K<sup>+</sup>-selective channel activity during differentiation of the Purkinje neuron in culture. Journal of Neuroscience, 8(6), 1971-1980. DOI Scopus49 WoS62 Europe PMC48
1988	Yool, A. J., Gruol, D. L., & Dionne, V. E. (1988). Voltage-sensitive K+ channels contribute to dendritic excitability in cerebellar Purkinje neurons.. Symposia in Neuroscience, 6, 57-68.
1987	Yool, A. J., & Gruol, D. L. (1987). Development of spontaneous and glutamate-evoked activity is altered by chronic ethanol in cultured cerebellar Purkinje neurons. Brain Research, 420(2), 205-219. DOI Scopus27 WoS30 Europe PMC24
1986	YOOL, A. J., GRAU, S. M., HADFIELD, M. G., JENSEN, R. A., MARKELL, D. A., & MORSE, D. E. (1986). EXCESS POTASSIUM INDUCES LARVAL METAMORPHOSIS IN 4 MARINE INVERTEBRATE SPECIES. BIOLOGICAL BULLETIN, 170(2), 255-266. DOI WoS145
1984	BALOUN, A. J., & MORSE, D. E. (1984). IONIC CONTROL OF SETTLEMENT AND METAMORPHOSIS IN LARVAL HALIOTIS-RUFESCENS (GASTROPODA). BIOLOGICAL BULLETIN, 167(1), 124-138. DOI
1980	Morse, D. E., Duncan, H., Hooker, N., Baloun, A., & Young, G. (1980). GABA induces behavioral and developmental metamorphosis in planktonic molluscan larvae. Fed Proc, 39(14), 3237-3241.

Book Chapters

Year	Citation
2016	Pei, J., Ameliorate, J., Kourghi, M., De Ieso, M., & Yool, A. (2016). Drug Discovery and Therapeutic Targets for Pharmacological Modulators of Aquaporin Channels. In G. Soveral, S. Nielsen, & A. Casini (Eds.), Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery (pp. 273-296). Boca Raton, FL: CRC Press. Scopus9
2008	Stamer, W., Baetz, N., & Yool, A. (2008). Ocular aquaporins and aqueous humor dynamics. In The Eye's Aqueous Humor (Vol. 62, 2 ed., pp. 47-70). San Diego, California: Elsevier. DOI Scopus7 WoS6

Conference Papers

Year	Citation
2021	Khan, S., Yool, A., & Ricciardelli, C. (2021). EXPRESSION OF AQUAPORINS IN HUMAN ENDOMETRIAL CANCER: IDENTIFICATION AND REGULATION BY OVARIAN HORMONES IN CARCINOGENESIS OF ENDOMETRIAL CANCER. In INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 31 (pp. A75). BMJ PUBLISHING GROUP. DOI
2020	Montiel, V., Bella, R., Michel, L., Robinson, E., Jonas, J. C., Michel, T., . . . Balligand, J. L. (2020). Inhibition of the water channel aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. In EUROPEAN HEART JOURNAL Vol. 41 (pp. 3665). ELECTR NETWORK: OXFORD UNIV PRESS.
2015	Tomita, Y., Dorward, H., Wrin, J., Vary, R. J., De Ieso, M. L., Yool, A. J., . . . Hardingham, J. E. (2015). The effect of aquaporin-5 knockdown on HT29 colon cancer cell proliferation and migration. In ANNALS OF ONCOLOGY Vol. 26 (pp. 4). Singapore, SINGAPORE: OXFORD UNIV PRESS.
2004	Migliati, E. R., Ritter, L., & Yool, A. J. (2004). A strategy for drug discovery for cerebral oedema after stroke. In JOURNAL OF NEUROLOGY Vol. 251 (pp. 58). Barcelona, SPAIN: DR DIETRICH STEINKOPFF VERLAG.
2004	Falk, T., Erbe, E. L., Yool, A. J., & Shermann, S. J. (2004). Neurochemical and electrophysiological characterization of cultured rat striatal neurons as a model system for gene therapy.. In BIOPHYSICAL JOURNAL Vol. 86 (pp. 270A). Baltimore, MD: BIOPHYSICAL SOCIETY.
2003	Falk, T., Kumar, A., Yool, A. J., & Carnevale, N. T. (2003). Modeling overexpression of different K<SUP>+</SUP> channels in myotubes. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 420A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003	Birdsell, D. N., & Yool, A. J. (2003). Regulation of cGMP-gated conductance and water permeability of Aqp1 channels by the carboxyl terminal domain.. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 400A-401A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003	Kruer, M. C., Erbe, E. L., Yool, A. J., & Sherman, S. J. (2003). Changes in the expression of EF-hand calcium binding proteins in rat fetal hippocampal neurons treated with basic fibroblast growth factor and neurotrophin-3.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 51 (pp. S110). CARMEL, CALIFORNIA: B C DECKER INC.
2002	Boassa, D., & Yool, A. J. (2002). Contribution of single amino acids in the carboxyl terminal domain of Aquaporin-1 channels to cGMP-dependent activation. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 275A). BIOPHYSICAL SOCIETY.
2002	Yool, A. J. (2002). Block by divalent cations of the cyclic-GMP-gated ionic conductance in human Aquaporin-1 channels. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 275A). BIOPHYSICAL SOCIETY. WoS1
2002	Birdsell, D. N., & Yool, A. J. (2002). Voltage dependence of tea block of osmotic water permeability in Aquaporin 1 channels. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 274A-275A). BIOPHYSICAL SOCIETY.
2001	Yool, A. J., & Boassa, D. (2001). Cyclic-GMP-dependent activation of Aquaporin-1 ion channels.. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 102A). BIOPHYSICAL SOCIETY.
2001	Boassa, D., & Yool, A. (2001). Voltage-sensitive rate of activation of aquaporin-1 channels by cGMP.. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 633A). BIOPHYSICAL SOCIETY.
2001	Falk, T., Kilani, R. K., Yool, A. J., & Sherman, S. J. (2001). Viral-vector-mediated expression of K<SUP>+</SUP> channels regulates electrical excitability in skeletal muscle. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 648A). BIOPHYSICAL SOCIETY. WoS1
2001	Yanochko, G. M., & Yool, A. J. (2001). Cation permeability and divalent cation block of big brain channels. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 204A). BIOPHYSICAL SOCIETY.
2000	Anthony, T. L., Pujino, H., Pierce, K. L., Yool, A. J., & Regan, J. W. (2000). Differential activation of Ca<SUP>2+</SUP>-dependent Cl<SUP>-</SUP> currents by FP prostanoid receptor isoforms in <i>Xenopus</i> oocytes.. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 41 (pp. S250). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
2000	Yanochko, G. M., Vaillancourt, R. R., Regan, J. W., & Yool, A. J. (2000). The MIP-related channel, big brain is regulated by tyrosine phosphorylation in Xenopus oocytes.. In FASEB JOURNAL Vol. 14 (pp. A344). FEDERATION AMER SOC EXP BIOL.
2000	Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In FASEB JOURNAL Vol. 14 (pp. A71). FEDERATION AMER SOC EXP BIOL.
2000	Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 183A). LIPPINCOTT WILLIAMS & WILKINS.
2000	Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (2000). Expression of a potassium channel-reporter gene fusion protein in cultured rat skeletal myocytes.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 87A). LIPPINCOTT WILLIAMS & WILKINS.
2000	Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 77A). LIPPINCOTT WILLIAMS & WILKINS.
2000	Yool, A. J., Boassa, D., Anthony, T. L., & Regan, J. W. (2000). Mechanisms of activation of aquaporin-1 ion channel function. In FASEB JOURNAL Vol. 14 (pp. A344). FEDERATION AMER SOC EXP BIOL.
1999	Brooks, H. L., Regan, J. W., & Yool, A. J. (1999). Inhibition of aquaporin-1 water permeability by TEA.. In FASEB JOURNAL Vol. 13 (pp. A394). FEDERATION AMER SOC EXP BIOL. WoS3
1999	Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel -reporter gene fusion protein in cultured hippocampal neurons. In Journal of Investigative Medicine Vol. 47 (pp. 34A). SLACK INC.
1999	Kilani, R. K., Faik, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel-reporter gene fusion protein in cultured hippocampal neurons.. In FASEB JOURNAL Vol. 13 (pp. A472). FEDERATION AMER SOC EXP BIOL.
1999	Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel-reporter gene fusion protein in cultured hippocampal neurons.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 47 (pp. 196A). SLACK INC.
1999	Sherman, S. J., Falk, T., Borders, R. J., Srazdas, L. A., & Yool, A. J. (1999). Viral vector-mediated trans-gene expression of an antisense sequence targeting knockdown of the β<sub>1.1</sub>-subunit of the K<sub>V</sub>1 voltage-gated potassium channels in cultured hippocampal neurons.. In EPILEPSIA Vol. 40 (pp. 11). LIPPINCOTT WILLIAMS & WILKINS.
1999	Sutherland, V., Murphy, S., Yool, A., & Lynch, R. (1999). Bimodal responses of cultured hypothalamic neurons.. In FASEB JOURNAL Vol. 13 (pp. A748). FEDERATION AMER SOC EXP BIOL.
1997	Lynch, R. M., Tucker, V. A., Sutherland, G., & Yool, A. (1997). Mechanisms of glucose sensing by neurons of the hypothalamus.. In FASEB JOURNAL Vol. 11 (pp. 3624). FEDERATION AMER SOC EXP BIOL.
1996	Pierce, K. L., Yool, A. J., Woodward, D. F., Gil, D. W., & Regan, J. W. (1996). Second messenger coupling of two FP prostanoid receptor carboxy terminal isoforms. In MOLECULAR BIOLOGY OF THE CELL Vol. 7 (pp. 3458). AMER SOC CELL BIOLOGY.
1996	Stamer, W. D., Regan, J. W., & Yool, A. J. (1996). Calcium influences water and cation fluxes in Xenopus oocytes expressing aquaporin-1. In MOLECULAR BIOLOGY OF THE CELL Vol. 7 (pp. 1488). AMER SOC CELL BIOLOGY.
1988	GRUOL, D. L., & YOOL, A. J. (1988). IDENTIFICATION OF K+ CHANNEL TYPES MEDIATING SPIKE EVENTS IN CEREBELLAR PURKINJE NEURONS. In BIOPHYSICAL JOURNAL Vol. 53 (pp. A458). BIOPHYSICAL SOCIETY. WoS1
1986	YOOL, A. J., & GRUOL, D. L. (1986). CHRONIC ETHANOL ALTERS THE SPONTANEOUS ACTIVITY OF DEVELOPING PURKINJE NEURONS IN CULTURE. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 10 (pp. 121). WILLIAMS & WILKINS.
1985	YOOL, A. J., & MORSE, D. E. (1985). IONIC CONTROL OF METAMORPHOSIS IN GASTROPOD LARVAE. In AMERICAN ZOOLOGIST Vol. 25 (pp. 287). AMER SOC ZOOLOGISTS.

Conference Items

Year	Citation
2021	Khan, S., Ricciardelli, C., & Yool, A. (2021). EPV114/# 325 Expression of aquaporins in human endometrial cancer: identification and regulation by ovarian hormones in carcinogenesis of endometrial cancer. Poster session presented at the meeting of International gynaecological cancer society.
2021	Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells.. Poster session presented at the meeting of EMBL Australia.
2021	Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Metastasis Research Society (OzMRS).
2021	Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Physiological society (AuPS) (oral presentation).
2021	Khan, S., Ricciardelli, C., & Yool, A. (2021). Identification of Aquaporins in human endometrial cancer and regulation by ovarian hormones in carcinogenesis.. Poster session presented at the meeting of The Australian Society for Medical Research National Scientific Conference, Adelaide, Australia..
2020	Nourmohammadi, S., & Yool, A. (2020). (Oral presentation) Discovering New Cancer-linked Ion Channels using a Photoswitchable Lithium Porbe. Poster session presented at the meeting of 3-minutes talk competition, The Institute for Photonics and Advanced Sensing (IPAS). University of Adelaide.
2019	Nourmohammadi, S., Nwe Aung, T., Cui, J., Pei, J., De leso, M., Qu, Z., . . . Yool, A. (2019). (Oral presentation) Systematic dissection of the molecular actions of compounds from traditional medicinal mixtures on the migration, invasion and apoptosis of brain, bowel and breast cancer cells. Poster session presented at the meeting of AuPS/ABS Meeting, Canberra, 2019.
2019	Nourmohammadi, S., Yool, A., & Adelson, D. (2019). (Poster presentation) Natural Compounds as Potential Anti-metastatic Treatments for Brain, Bowel and Breast Cancer. Poster session presented at the meeting of Florey Postgraduate Conference.
2018	Pei, J. V., Heng, S., De Ieso, M., Sylvia, G., Kourghi, M., Abell, A. D., & Yool, A. J. (2018). Real-Time Imaging of Lithium 'Hot-Spots': An Analysis of Ion Conductance in Aquaporin-1 using Novel Photo-Switchable Sensor. Poster session presented at the meeting of BIOPHYSICAL JOURNAL. San Francisco, CA: CELL PRESS.
2018	Nourmohammadi, S., Nwe Aung, T., Yool, A., & Adelson, D. (2018). (Poster presentation) Fractional Deletion of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical for Its Perturbation of The Cell Cycle. Poster session presented at the meeting of Florey Postgraduate Conference.
2018	Nourmohammadi, S., Yool, A., & Adelson, D. (2018). (Poster presentation) Discovery of the Anti-metastasic Activity of a Chinese medicinal herb mixture 'Compound Kushen Injection' and Identification of the Active Components in Brain, Colon and Breast Cancer Cell Lines. Poster session presented at the meeting of Australian Society for Medical Research (ASMR).
2018	Palethorpe, H. M., Tomita, Y., Smith, E., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Bacopaside II reduces endothelial cell migration and angiogenesis in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne.
2018	Smith, E., Palethorpe, H. M., Tomita, Y., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Anti-tumour effects of Bacopaside II on colorectal cancer cells in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne, VIC.
2017	Nourmohammadi, S., Pie, V. J., Kourghi, M., De leso, M. L., Pak, C., Adelson, D. L., & Yool, A. J. (2017). (Oral presentation) Analysis of effective compounds and mechanisms of action of a Chinese traditional herbal medicine (Compound Kushen Injection) on aquaporins involved in cancer cell migration and metastasis.. Poster session presented at the meeting of Gage Ion Channels and Transporters Conference. Canberra, Australia.
2016	Byrt, C. S., Zhao, M., Kourghi, M., Bose, J., Henderson, S. W., Qui, J., . . . Tyerman, S. (2016). Charging up water transport with plant aquaporins permeable to ions. Poster session presented at the meeting of Combio2016. Brisbane, Australia.
2014	Eden, G., Lampton, L., Cheah, K., Lymn, K., Bajic, J., Yool, A., & Howarth, G. (2014). Aqueous rhubarb extract improves ileal mucosal integrity and reduces acute inflammation in a rat model of 5-fluorouracil-induced intestinal mucositis. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Broadbeach, Qld.: Wiley. DOI
2013	Pei, J., Campbell, E. M., & Yool, A. J. (2013). Inhibition of aquaporin-1 but not aquaporin-4 water permeability by bacopaside I derived from <i>Bacopa monnieri</i>. Poster session presented at the meeting of PLANTA MEDICA. GEORG THIEME VERLAG KG.
2012	Klebe, S., Griggs, K., Henderson, D. W., & Yool, A. J. (2012). MODULATION OF AQUAPORIN 1 AS A NOVEL TREATMENT STRATEGY FOR MALIGNANT MESOTHELIOMA. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. Adelaide, AUSTRALIA: ELSEVIER SCIENCE INC.

DATE

CURRENT GRANTS

Investigators

Funding Agency

2022-2024

Investigation the influence of wine macromolecules on aquaporin function and implications for taste signalling

AJ Yool

D Espinase Nandorfy

Australian Wine Research Institute / UoA Collaborative Research Investment Fund

2022-2024

Testing combined therapies as a powerful tool for controlling paediatric Glioblastoma multiforme invasiveness

SA Ramesh

AJ Yool

R Haberberger

Children's Research Foundation Ch 7, Australia

2022-2023

Developing novel therapeutic candidates for limiting invasive capabilities of Glioblastoma multiforme cells

SA Ramesh

AJ Yool

RA Davis

NeuroSurgical Research Foundation, Australia

PRIOR FUNDING

Date	Title	Investigators	Funding Agency
2019-2021	Fundamental roles of Aquaporin-1 channels in cellular migration and morphology (DP190101745)	AJ Yool and S Ramesh	Australian Research Council (ARC)
2019-2021	Channels for improved crop salt and water stress tolerance (DP190102725)	C Byrt, S Tyerman, AJ Yool, F Chaumont and M Tester	Australian Research Council (ARC)
2020-2022	Developing an animal-free analysis platform to assess human Aquaporin-1 channels involved in cancer cell migration.	S Henderson, AJ Yool, B Martinac	Medical Advances Without Animals

2016- 2018	Properties enabling rapid cell migration by aquaporin-1 channel expression (DP160104641)	Yool	Australian Research Council (ARC)
2015	Characterisation of aquaporin-1 (AQP1) ion channel activity in migrating cancer cells using a novel photoswitchable fluorescent probe	Yool	Institute for Photonics & Advanced Sensing
2011	Aquaporin physiology and drug discovery	Yool	Adelaide Centre for Neuroscience Research
2010	Role of Aquaporins in mesothelioma	Klebe,Yool	Flinders Medical Research Foundation
2010	Cloning the Neoparameoba aquaporin channel as a target for parasite control in finfish	Cook, Yool	CRC Seafood Research Foundation
2010	Role of the brain water channel aquaporin-4 in development and epilepsy	Yool	Children’s Research Foundation Channel7
2009	Water and ion channel blocking activity of novel neurological agents	Yool	Neurotherapeutics, Chicago IL USA
2009	The effects of novel aquaporin 4 channel blockers on reducing post stroke edema	Chen, Yool	Ramaciotti foundation
2006 - 09	Development of novel blockers of Aquaporin-4 channels with translational relevance to stroke-induced brain edema	Yool	BIO5 Pilot grant, AZ USA
2004 - 09	Predoctoral Training Program in Neuroscience (NIH T321 007434-07)	Yool	National Institutes of Health (NIH), USA
2003 - 07	Structural basis of ion channel function in Aquaporin-1 (NIH-R01-GM59986)	Yool	National Institutes of Health (NIH), USA

Current teaching contributions:

Principles of Human Health and Disease (Hlth Sci 1005)

Physiology IIB (Physiol 2520) Systems and Homeostasis

Cellular & Systems Neurobiology (Physiol 3104)

BHMS Year 3 Research Placement Course (Hlth Sci X)

* Research Skills Development, BMS year 3 (Med Stud 3503)

Health Sciences Honours Research (AMS)

Honours Research Skills (AMS)

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* current course coordinator

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2022	Principal Supervisor	Characterization of Drugs Modulating the Aquaporin Channel Activity to Inhibit Angiogenesis and Metastasis	Doctor of Philosophy	Doctorate	Full Time	Ms Kim Kristin Wagner
2020	Principal Supervisor	Analysing the role of Aquaporin channels in the progression of endometrial carcinoma	Doctor of Philosophy	Doctorate	Full Time	Ms Sidra Nawaz Khan

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2021 - 2023	Principal Supervisor	Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels	Master of Philosophy (Medical Science)	Master	Full Time	Miss Alanah Varricchio
2020 - 2023	Principal Supervisor	Discovery of novel aquaporin subtypes in the human brain: Potential relevance of peroxiporins AQP0 and AQP11 to cellular stress and Alzheimer’s Disease	Doctor of Philosophy	Doctorate	Full Time	Mr Zein Alabedyn Amro
2018 - 2022	Co-Supervisor	Bt toxins: using flies, moths, and oocytes to unravel a complex mode of action	Doctor of Philosophy	Doctorate	Full Time	Mr Biko Kahare Muita
2018 - 2023	Principal Supervisor	Aquaporins - from Ion Channels to Human Cancers	Doctor of Philosophy	Doctorate	Full Time	Mr Saeed Nourmohammadi
2016 - 2022	Principal Supervisor	Role of Aquaporin 1 in Diseases and Drug Discovery	Doctor of Philosophy	Doctorate	Full Time	Mr Pak Hin Chow
2015 - 2021	Co-Supervisor	Evaluation of Anti-Cancer Effect of Synthetic and Plant-based Inhibitors of Aquaporin 1 in Colon Cancer	Doctor of Philosophy	Doctorate	Part Time	Miss Yoko Tomita
2015 - 2019	Principal Supervisor	Pharmacological Modulation of Cancer Migration and Invasion Through Targeting AQP1 Ion and Water Channel Activity	Doctor of Philosophy	Doctorate	Full Time	Michael Lucio De Ieso
2013 - 2017	Co-Supervisor	A Clarification of the Aetiology and Pathogenesis of Renal Tubular Epithelial Cell Vacuolization in Diabetic Ketoacidosis	Doctor of Philosophy	Doctorate	Part Time	Chong Zhou
2013 - 2018	Principal Supervisor	A Comparative Study of Physiological and Modulators of Aquaporin ion Channels in Diverse Phyla	Doctor of Philosophy	Doctorate	Full Time	Mohamad Kourghi
2012 - 2014	Co-Supervisor	AQUAPORINS: GATEKEEPERS OF OEDEMA IN TRAUMATIC BRAIN INJURY	Doctor of Philosophy	Doctorate	Full Time	Dr Joshua Luke Burton
2011 - 2016	Co-Supervisor	Evaluation of Indices of Affective State in a Rat Model of Chemotherapy-induced Mucositis	Doctor of Philosophy	Doctorate	Part Time	APrf Alexandra Whittaker
2011 - 2017	Principal Supervisor	Aquaporin in Cancer Cell Migration: Discovery of New Pharmacological Blockers and a Novel Lithium Sensor	Doctor of Philosophy	Doctorate	Full Time	Dr Jinxin Pei
2009 - 2010	Principal Supervisor	Towards Gene Therapy for Cystic Fibrosis Airway Disease: Development of a Single-Dose Lentiviral Gene Transfer for Lifetime Airway Expression	Doctor of Philosophy	Doctorate	Part Time	Ms Alice Stocker
2008 - 2008	Principal Supervisor	Characterisation of a Dominant Negative Androgen Receptor in Prostate Cancer Cells	Doctor of Philosophy	Doctorate	Part Time	Dr Margaret Centenera

Memberships

Date	Role	Membership	Country
2008 - ongoing	Member	Australian Physiology Society	Australia
2007 - ongoing	Member	Australian Society for Biophysics	Australia
2006 - ongoing	Member	Member of Evelyn McKnight Brain Institute	United States
2002 - ongoing	Member	American Society for Pharmacology and Experimental Therapeutics	United States

Editorial Boards

Date Role Editorial Board Name Institution Country

2020 - ongoing Board Member Associate Editor, Frontiers in Pharmacology Frontiers Switzerland
Review, Assessment, Editorial and Advice

Date Title Type Institution Country

2019 - 2022 ARC College of Experts member (2019-2022) Grant Assessment Australian Research Council -

Date	Role	Editorial Board Name	Institution	Country
2020 - ongoing	Board Member	Associate Editor, Frontiers in Pharmacology	Frontiers	Switzerland

Date	Title	Type	Institution	Country
2019 - 2022	ARC College of Experts member (2019-2022)	Grant Assessment	Australian Research Council	-

Position: Professor of Physiology
Phone: 83133359
Email: andrea.yool@adelaide.edu.au
Fax: 83134398
Campus: North Terrace
Building: Helen Mayo North, floor 2
Org Unit: Medical Sciences

Professor Andrea Yool

Research

Appointments

Education

Postgraduate Training

Research Interests

Journals

Book Chapters

Conference Papers

Conference Items

Current Higher Degree by Research Supervision (University of Adelaide)

Past Higher Degree by Research Supervision (University of Adelaide)

Memberships

Editorial Boards

Review, Assessment, Editorial and Advice

Connect With Me

External Profiles