Andrea Yool

Research Interests

Basic Pharmacology Biochemistry and Cell Biology Cancer Therapy Neurosciences Pharmacology and Pharmaceutical Sciences Proteins and Peptides Cancer Biology and Clinical Oncology Neuroscience, Behaviour and Brain Health Translational Health Outcomes Innovative Therapeutics

Prof Andrea Yool

Professor of Physiology

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Andrea is a Professor of Physiology at Adelaide University, a member of the Institute for Photonics and Advanced Sensing, and Director of Aquaporin Physiology and Drug Discovery Program. She has a strong publication record in ion channel and water channel physiology, with more than 100 publications, book chapters and review articles  including top tier journals (Science, Nature and PNAS). She has catalysed excellence in research scholarship having supervised research projects for more than 40 Bachelor and Honours students, and served as principal or co-supervisor to over 60 HDR students, and 5 postdoctoral fellows and MD/PhD research fellows over her career. Her work is defining the roles of AQPs in physiological systems, and amassing a portfolio of AQP antagonist and agonist compounds as tools for basic research and clinical innovation.

Research

Andrea is a Professor of Physiology and a member of the Institute for Photonics at Adelaide University. She earned her PhD from the University of California Santa Barbara,  completed research fellowships at Scripps Clinic and Stanford University, then joined academic staff at the University of Arizona with joint appointments in Physiology, Pharmacology, Neuroscience. She accepted a position at Adelaide University (formerly University of Adelaide) as Head of Physiology in 2007, and continues a strong track record of advances in membrane signalling and cancer therapeutics (H-index 49). Her team is defining the molecular basis of aquaporin channel function, and building a portfolio of aquaporin modulators as leads for clinical innovation.

AQUAPORIN PHYSIOLOGY AND DRUG DISCOVERY RESEARCH PROGRAM

The clinical challenge for treating glioblastoma (GBM) brain cancers is that even with best current therapy (which combines surgical resection, radiation therapy and chemotherapy), median survival time is still only ~15 months post-diagnosis. The main clinical challenge that remains unaddressed is how to control the lethal spreading of these highly invasive cells. We hypothesised that unique features of glioblastoma which enhance cell motility not only drive pathology but also create points of vulnerability, which we are exploiting to create new treatments. The main focus in our Aquaporin Drug Discovery and Physiology research program at Adelaide University is on  Aquaporin-1 dual water and ion channels, which are upregulated in leading edges of highly motile types of cells including GBM, colon cancer, endometrial cancer, and neural crest cells. 

In collaboration with Sunita Ramesh (Flinders University) and Rohan Davis (Griffith University), we have discovered a new structurally-related array of indole alkaloid compounds that potently block of GBM invasiveness at very low (submicromolar) doses without toxicity in adult and paediatric GBM. These agents are the most potent blockers of Aquaporin-1 channels yet described. Ongoing molecular, imaging, electrophysiology and medicinal chemistry work is aimed at defining target sites, mechanisms of action, and optimising lead compounds for future clinical translation into adjunct therapies that essentially would hold GBM cells in place, preventing escape that leads to recurrence, while other first line treatments are in progress. Our drug agents are currently being tested in collaborative projects in Australia, Europe and the USA.

CURRENT RESEARCH PROJECT: Using cell culture, molecular biology, expression systems, imaging, and pharmacological tools, we are defining mechanisms and discovering novel drugs for controlling the invasiveness of glioblastoma (brain cancer) cells, in collaboration with Dr Sunita Ramesh, Flinders University and Dr Rohan Davis, Griffith Uni QLD. Projects are available for Honours and Masters of Research students.

Location-- Available projects are conducted in the Yool laboratory, Helen Mayo South, level 2, Frome Rd (North Terrace campus). 

Special requirements--  No special requirements apply; however, having completed  year 3 Cell & Systems Neurobiology as well as a first year chemistry, biochemistry, molecular biology or the equivalent are highly recommended.

Date Position Institution name
2007 - ongoing Professor of Physiology University of Adelaide
2004 - 2007 Professor University of Arizona
1998 - 2004 Associate Professor University of Arizona
1992 - 1998 Assistant Professor University of Arizona

Date Institution name Country Title
1980 - 1985 University of California, Santa Barbara United States PhD

Date Title Institution Country
1990 - 1992 Postdoctoral Scholar Stanford University United States
1985 - 1989 Postdoctoral Research Fellow Scripps Research Institute United States

Year Citation
2026 Wagner, K. K., Fotiou, M., Suo, S. J., Ramesh, S. A., Davis, R. A., & Yool, A. J. (2026). Semisynthetic indole alkaloids restrain the invasiveness of glioblastoma cell lines and inhibit human Aquaporin-1 water channels. Biochemical Pharmacology, 244, 117613-1-117613-16.
DOI
2026 Wagner, K. K., Heinze, A., Zenz, T., Yool, A. J., Franke, H., & Aigner, A. (2026). Xenograft tissue slice tandem co-cultures are a highly specific model to selectively analyze drug inhibitory effects on invasion. JOURNAL OF BIOLOGICAL CHEMISTRY, 302(1), 16 pages.
DOI
2026 Yool, A. J. (2026). Structural Domains Associated with Permeation, Gating, and Selectivity of Aquaporin Ion Channels Found Across Phyla.. Advances in experimental medicine and biology, 1497, 307-325.
DOI
2026 Khan, S., Lokman, N. A., Oehler, M. K., Ricciardelli, C., & Yool, A. J. (2026). Correction: Khan et al. Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. Cancers 2023, 15, 4507. Cancers, 18(6), 996.
DOI
2025 Al-Samir, S., Kyriazi, D., Yool, A. J., Moser, I., Kyriazi, K., Gros, G., . . . Endeward, V. (2025). Aquaporin-1 acts as an O2 channel. The permeability of human and mouse red cell membranes for oxygen.. Am J Physiol Cell Physiol, 328(5), C1605-C1622.
DOI Scopus2 WoS3 Europe PMC8
2025 Espinase Nandorfy, D., Khan, S., Wang, S., Kulathunga, B., Peirce, E., & Yool, A. J. (2025). Astringent Effects of Red Wine Associated with Responses of Aquaporins Found in Human Tongue and Salivary Tissues.. J Agric Food Chem, 73(33), 21035-21047.
DOI Scopus3 WoS3 Europe PMC1
2024 Ahmed, J., Ismail, A., Ding, L., Yool, A. J., & Chaumont, F. (2024). A new method to measure aquaporin-facilitated membrane diffusion of hydrogen peroxide and cations in plant suspension cells. Plant, Cell and Environment, 47(2), 527-539.
DOI Scopus12 WoS11 Europe PMC9
2024 Amro, Z., Collins-Praino, L. E., & Yool, A. J. (2024). Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cells in response to oxidative and inflammatory stressors.. Biosci Rep, 44(3), 21 pages.
DOI Scopus12 WoS13 Europe PMC11
2024 Nourmohammadi, S., Henderson, S. W., Ramesh, S. A., & Yool, A. J. (2024). Characterization of human Aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery. Bioscience Reports: molecular and cellular biology of the cell surface, 44(8), BSR20240542-1-BSR20240542-20.
DOI Scopus2 WoS1 Europe PMC2
2023 Varricchio, A., & Yool, A. J. (2023). Aquaporins and Ion Channels as Dual Targets in the Design of Novel Glioblastoma Therapeutics to Limit Invasiveness. Cancers, 15(3), 849.
DOI Scopus9 WoS8 Europe PMC8
2023 Varricchio, A., Khan, S., Price, Z. K., Davis, R. A., Ramesh, S. A., & Yool, A. J. (2023). Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro. Cancers, 15(4), 1-20.
DOI Scopus16 WoS16 Europe PMC13
2023 Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15.
DOI Scopus5 WoS4 Europe PMC4
2023 Varricchio, A., Yool, A. J., & Ramesh, S. A. (2023). Subtype-specific block of glioblastoma motility through dual inhibition of water and ion flux. Biophysical Journal, 122(3), 255a-256a.
DOI
2023 Amro, Z., Ryan, M., Collins-Praino, L. E., & Yool, A. J. (2023). Unexpected Classes of Aquaporin Channels Detected by Transcriptomic Analysis in Human Brain Are Associated with Both Patient Age and Alzheimer’s Disease Status. Biomedicines, 11(3), 1-19.
DOI Scopus11 WoS11 Europe PMC11
2023 Khan, S., Lokman, N. A., Oehler, M. K., Ricciardelli, C., & Yool, A. J. (2023). Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. Cancers, 15(18), 4507-1-4507-27.
DOI Scopus3 WoS2 Europe PMC2
2022 Khan, S., Varricchio, A., Ricciardelli, C., & Yool, A. J. (2022). Invasiveness of endometrial cancer cell lines is potentiated by estradiol and blocked by a traditional medicine Guizhi Fuling at clinically relevant doses.. Frontiers in Oncology, 12, 15 pages.
DOI Scopus6 WoS5 Europe PMC5
2022 Salman, M. M., Kitchen, P., Yool, A. J., & Bill, R. M. (2022). Recent breakthroughs and future directions in drugging aquaporins. Trends in Pharmacological Sciences, 43(1), 30-42.
DOI Scopus86 WoS87 Europe PMC80
2022 Henderson, S. W., Nourmohammadi, S., Ramesh, S. A., & Yool, A. J. (2022). Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology. Biophysical Reviews, 14(1), 181-198.
DOI Scopus21 WoS19 Europe PMC14
2022 Wagner, K., Unger, L., Salman, M. M., Kitchen, P., Bill, R. M., & Yool, A. J. (2022). Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease. International Journal of Molecular Sciences, 23(3), 1388.
DOI Scopus93 WoS87 Europe PMC78
2021 Chow, P. H., Cox, C. D., Pei, J. V., Anabaraonye, N., Nourmohammadi, S., Henderson, S. W., . . . Yool, A. J. (2021). Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling.. Frontiers in pharmacology, 12, 1-13.
DOI Scopus11 WoS9 Europe PMC8
2021 Tomita, Y., Smith, E., Palethorpe, H. M., Nakhjavani, M., Yeo, K. K. L., Townsend, A. R., . . . Hardingham, J. E. (2021). In vitro synergistic inhibition of HT-29 proliferation and 2H-11 and HUVEC tubulogenesis by bacopaside I and II Is associated with Ca²⁺ flux and loss of plasma membrane integrity. Pharmaceuticals, 14(5), 1-18.
DOI Scopus8 WoS6 Europe PMC3
2021 Nakhjavani, M., Smith, E., Yeo, K., Tomita, Y., Price, T. J., Yool, A., . . . Hardingham, J. E. (2021). Differential antiangiogenic and anticancer activities of the active metabolites of ginsenoside Rg3. Journal of Ginseng Research, 48(2), 10 pages.
DOI Scopus11 WoS11 Europe PMC8
2021 Amro, Z., Yool, A. J., & Collins-Praino, L. E. (2021). The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathies. Brain, behavior, & immunity - health, 14, 100242-1-100242-14.
DOI Scopus29 WoS25 Europe PMC23
2021 Varricchio, A., Ramesh, S. A., & Yool, A. J. (2021). Novel ion channel targets and drug delivery tools for controlling glioblastoma cell invasiveness. International Journal of Molecular Sciences, 22(21), 11909-1-11909-22.
DOI Scopus13 WoS12 Europe PMC11
2021 Khan, S., Ricciardelli, C., & Yool, A. J. (2021). Targeting aquaporins in novel therapies for male and female breast and reproductive cancers. Cells, 10(2), 1-18.
DOI Scopus24 WoS21 Europe PMC18
2021 Tyerman, S. D., McGaughey, S. A., Qiu, J., Yool, A. J., & Byrt, C. S. (2021). Adaptable and multifunctional ion-conducting aquaporins. Annual Review of Plant Biology, 72(1), 1-34.
DOI Scopus92 WoS81 Europe PMC61
2020 Chow, P. H., Kourghi, M., Pei, J. V., Nourmohammadi, S., & Yool, A. J. (2020). 5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion. Mol Pharmacol, 98(1), 38-48.
DOI Scopus32 WoS31 Europe PMC25
2020 Fabrick, J. A., Yool, A. J., & Spurgeon, D. W. (2020). Insecticidal activity of marigold Tagetes patula plants and foliar extracts against the hemipteran pests, Lygus hesperus and Bemisia tabaci. PLoS ONE, 15(5), 15 pages.
DOI Scopus45 WoS32 Europe PMC11
2020 Chow, P. H., Bowen, J., & Yool, A. J. (2020). Combined systematic review and transcriptomic analyses of mammalian aquaporin classes 1 to 10 as biomarkers and prognostic indicators in diverse cancers. Cancers, 12(7), 1-31.
DOI Scopus27 WoS28 Europe PMC21
2020 Montiel, V., Bella, R., Michel, L. Y. M., Esfahani, H., De Mulder, D., Robinson, E. L., . . . Balligand, J. -L. (2020). Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Science Translational Medicine, 12(564), 1-16.
DOI Scopus60 WoS58 Europe PMC61
2020 Yool, A. J., & Ramesh, S. (2020). Molecular targets for combined therapeutic strategies to limit glioblastoma cell migration and invasion. Frontiers in Pharmacology, 11, 358-1-358-26.
DOI Scopus41 WoS39 Europe PMC35
2019 Pei, J. V., Heng, S., De Ieso, M. L., Sylvia, G., Kourghi, M., Nourmohammadi, S., . . . Yool, A. J. (2019). Development of a photoswitchable lithium-sensitive probe to analyze nonselective cation channel activity in migrating cancer cells. Molecular Pharmacology, 95(5), 573-583.
DOI Scopus26 WoS23 Europe PMC16
2019 Tomita, Y., Palethorpe, H. M., Smith, E., Nakhjavani, M., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2019). Bumetanide-derived aquaporin 1 inhibitors, AqB013 and AqB050 inhibit tube formation of endothelial cells through induction of apoptosis and impaired migration in vitro. International Journal of Molecular Sciences, 20(8), 1818-1-1818-11.
DOI Scopus21 WoS23 Europe PMC20
2019 Nourmohammadi, S., Aung, T. N., Cui, J., Pei, J., De Ieso, M. L., Harata-Lee, Y., . . . Yool, A. J. (2019). Effect of compound kushen injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Frontiers in Oncology, 9(APR), 1-14.
DOI Scopus53 WoS52 Europe PMC48
2019 Nakhjavani, M., Palethorpe, H. M., Tomita, Y., Smith, E., Price, T. J., Yool, A. J., . . . Hardingham, J. E. (2019). Stereoselective anti-cancer activities of ginsenoside Rg3 on triple negative breast cancer cell models. Pharmaceuticals, 12(3), 117-1-117-14.
DOI Scopus45 WoS36 Europe PMC30
2019 De Ieso, M. L., Pei, J. V., Nourmohammadi, S., Smith, E., Chow, P. H., Kourghi, M., . . . Yool, A. J. (2019). Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration. Scientific Reports, 9(1), 12635-1-12635-17.
DOI Scopus44 WoS41 Europe PMC31
2019 Aung, T. N., Nourmohammadi, S., Qu, Z., Harata-Lee, Y., Cui, J., Shen, H. Y., . . . Adelson, D. L. (2019). Fractional deletion of Compound Kushen Injection indicates cytokine signaling pathways are critical for its perturbation of the cell cycle. Scientific Reports, 9(1), 14200-1-14200-16.
DOI Scopus12 WoS10 Europe PMC14
2019 Palethorpe, H. M., Smith, E., Tomita, Y., Nakhjavani, M., Yool, A. J., Price, T. J., . . . Hardingham, J. E. (2019). Bacopasides I and II act in synergy to inhibit the growth, migration and invasion of breast cancer cell lines. Molecules, 24(19), 3539-1-3539-16.
DOI Scopus41 WoS34 Europe PMC26
2018 Smith, E., Palethorpe, H. M., Tomita, Y., Pei, J., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2018). The purified extract from the medicinal plant Bacopa monnieri, bacopaside II, inhibits growth of colon cancer cells in vitro by inducing cell cycle arrest and apoptosis. Cells, 7(7), 81-1-81-11.
DOI Scopus61 WoS55 Europe PMC41
2018 Kourghi, M., Pei, J., De Ieso, M., Nourmohammadi, S., Chow, P., & Yool, A. (2018). Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Clinical and Experimental Pharmacology and Physiology, 45(4), 401-409.
DOI Scopus45 WoS44 Europe PMC37
2018 Palethorpe, H., Tomita, Y., Smith, E., Pei, J., Townsend, A., Price, T., . . . Hardingham, J. (2018). The aquaporin 1 inhibitor bacopaside II reduces endothelial cell migration and tubulogenesis and induces apoptosis. International Journal of Molecular Sciences, 19(3), 653-1-653-10.
DOI Scopus33 WoS33 Europe PMC23
2018 De Ieso, M., & Yool, A. (2018). Mechanisms of aquaporin-facilitated cancer invasion and metastasis. Frontiers in Chemistry, 6, 135-1-135-20.
DOI Scopus89 WoS81 Europe PMC78
2018 Kourghi, M., De Ieso, M., Nourmohammadi, S., Pei, J., & Yool, A. (2018). Identification of loop D domain amino acids in the human Aquaporin-1 channel involved in activation of the ionic conductance and inhibition by AqB011. Frontiers in Chemistry, 6(APR), 142-1-142-12.
DOI Scopus20 WoS19 Europe PMC20
2017 Kourghi, M., Nourmohammadi, S., Pei, J., Qiu, J., McGaughey, S., Tyerman, S., . . . Yool, A. (2017). Divalent cations regulate the ion conductance properties of diverse classes of aquaporins. International Journal of Molecular Sciences, 18(11), 2323-1-2323-19.
DOI Scopus65 WoS63 Europe PMC51
2017 Zhou, C., Yool, A., & Byard, R. (2017). Armanni–Ebstein Lesions in Terminal Hyperglycemia. Journal of Forensic Sciences, 62(4), 921-925.
DOI Scopus15 WoS14 Europe PMC8
2017 Zhou, C., Yool, A., & Byard, R. (2017). The Etiology of Basal Vacuolizations in Renal Tubular Epithelial Cells Evaluated in an Isolated Perfused Kidney Model. Journal of Forensic Sciences, 62(4), 915-920.
DOI Scopus6 WoS5 Europe PMC3
2017 Tomita, Y., Dorward, H., Yool, A. J., Smith, E., Townsend, A. R., Price, T. J., & Hardingham, J. E. (2017). Role of aquaporin 1 signalling in cancer development and progression. International Journal of Molecular Sciences, 18(2), 299-1-299-17.
DOI Scopus98 WoS94 Europe PMC79
2017 Zhou, C., Yool, A., & Byard, R. (2017). Basal vacuolization in renal tubular epithelial cells at autopsy and their relation to ketoacidosis. Journal of Forensic Sciences, 62(3), 681-685.
DOI Scopus14 WoS15 Europe PMC11
2017 Zhou, C., Yool, A. J., & Byard, R. W. (2017). An Isolated Perfused Rat Kidney Model for the Evaluation of the Effect of Glucose on Renal Tubular Epithelial Morphology. Journal of Forensic Sciences, 62(1), 5 pages.
DOI Scopus3 WoS3 Europe PMC2
2017 Byrt, C., Zhao, M., Kourghi, M., Bose, J., Henderson, S., Qiu, J., . . . Tyerman, S. (2017). Non-selective cation channel activity of aquaporin AtPIP2;1 regulated by Ca²⁺ and pH. Plant, Cell and Environment, 40(6), 802-815.
DOI Scopus182 WoS163 Europe PMC134
2016 Bajic, J., Eden, G., Lampton, L., Cheah, K., Lymn, K., Pei, J., . . . Howarth, G. (2016). Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World Journal of Gastroenterology, 22(37), 8322-8333.
DOI Scopus29 WoS26 Europe PMC18
2016 Dorward, H., Du, A., Bruhn, M., Wrin, J., Pei, J., Evdokiou, A., . . . Hardingham, J. (2016). Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro. Journal of Experimental & Clinical Cancer Research, 35(1), 36-1-36-9.
DOI Scopus73 WoS70 Europe PMC59
2016 Pei, J., Kourghi, M., De Ieso, M., Campbell, E., Dorward, H., Hardingham, J., & Yool, A. (2016). Differential inhibition of water and ion channel activities of mammalian aquaporin-1 by two structurally related bacopaside compounds derived from the medicinal plant bacopa monnieri. Molecular Pharmacology, 90(4), 496-507.
DOI Scopus67 WoS64 Europe PMC50
2016 Kourghi, M., Pei, J., De Ieso, M., Flynn, G., & Yool, A. (2016). Bumetanide derivatives AqB007 and AqB011 selectively block the aquaporin-1 ion channel conductance and slow cancer cell migration. Molecular Pharmacology, 89(1), 133-140.
DOI Scopus64 WoS61 Europe PMC61
2015 Zhou, C., Moore, L., Yool, A., Jaunzems, A., & Byard, R. (2015). Renal Tubular Epithelial Vacuoles-A Marker for Both Hyperlipidemia and Ketoacidosis at Autopsy. Journal of Forensic Sciences, 60(3), 638-641.
DOI Scopus15 WoS13 Europe PMC10
2015 Saint, D., Horton, D., Yool, A., & Elliott, A. (2015). A progressive assessment strategy improves student learning and perceived course quality in undergraduate physiology. Advances in Physiology Education, 39(3), 218-222.
DOI Scopus8 WoS7 Europe PMC1
2014 Fabrick, J., Pei, J., Hull, J., & Yool, A. (2014). Molecular and functional characterization of multiple aquaporin water channel proteins from the western tarnished plant bug, Lygus hesperus. Insect Biochemistry and Molecular Biology, 45(1), 125-140.
DOI Scopus31 WoS31 Europe PMC29
2014 Zhou, C., Bright, F., Winskog, C., Yool, A., & Byard, R. (2014). Lethal hypothermia in an animal model, not associated with basal renal epithelial vacuolization. Journal of Forensic and Legal Medicine, 21, 14-16.
DOI Scopus13 WoS9 Europe PMC8
2013 Zhou, C., Yool, A., & Byard, R. (2013). Renal cortical pallor - a useful macroscopic marker for metabolic derangements at autopsy. Journal of Forensic Sciences, 58(3), 693-696.
DOI Scopus5 WoS5 Europe PMC2
2013 Zhou, C., Gilbert, J., Yool, A., & Byard, R. (2013). Basal epithelial formalin pigment deposition in the kidneys - A useful marker for ketoacidosis at autopsy. Journal of Forensic and Legal Medicine, 20(4), 305-307.
DOI Scopus20 WoS17 Europe PMC14
2013 Zhou, C., Yool, A., Nolan, J., & Byard, R. (2013). Armanni–Ebstein lesions: A need for clarification. Journal of Forensic Sciences, 58(SUPPL. 1), S94-S98.
DOI Scopus49 WoS44 Europe PMC31
2013 Yool, A., Morelle, J., Cnops, Y., Verbavatz, J., Campbell, E., Spencer, E., . . . Devuyst, O. (2013). AqF026 is a pharmacologic agonist of the water channel aquaporin-1. Journal of the American Society of Nephrology, 24(7), 1045-1052.
DOI Scopus61 WoS55 Europe PMC52
2012 Yool, A., & Campbell, E. (2012). Structure, function and translational relevance of aquaporin dual water and ion channels. Molecular Aspects of Medicine, 33(5-6), 553-561.
DOI Scopus85 WoS74 Europe PMC69
2012 Baetz, N., Stamer, W., & Yool, A. (2012). Stimulation of Aquaporin-Mediated Fluid Transport by Cyclic GMP in Human Retinal Pigment Epithelium In Vitro. Investigative Ophthalmology & Visual Science, 53(4), 2127-2132.
DOI Scopus13 WoS9 Europe PMC11
2012 Campbell, E., Birdsell, D., & Yool, A. (2012). The activity of human aquaporin 1 as a cGMP-gated cation channel is regulated by tyrosine phosphorylation in the carboxyl-terminal domain. Molecular Pharmacology, 81(1), 97-105.
DOI Scopus52 WoS49 Europe PMC43
2012 Yool, A. J., & Campbell, E. M. (2012). Structure, function and translational relevance of aquaporin dual water and ion channels.. Mol Aspects Med, 33(5), 443-561.
2012 Byard, R. W., Zhou, C., Yool, A. J., Parai, J. L., & Milroy, C. M. (2012). Armanni-Ebstein Change or Basal Tubular Vacuolization?. Academic Forensic Pathology, 2(3), 304.
DOI
2011 Vandenberg, R., Handford, C., Campbell, E., Ryan, R., & Yool, A. (2011). Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. Biochemical Journal, 439(2), 333-340.
DOI Scopus18 WoS17 Europe PMC17
2011 Oliva Jr, A., Kang, Y., Truettner, J., Sanchez-Molano, J., Furones, C., Yool, A., & Atkins, C. (2011). Fluid-percussion brain injury induces changes in aquaporin channel expression. Neuroscience, 180, 272-279.
DOI Scopus25 WoS24 Europe PMC22
2011 Matthew, L., Campbell, E., Yool, A., & Fabrick, J. (2011). Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci. Insect Biochemistry and Molecular Biology, 41(3), 178-190.
DOI Scopus48 WoS47 Europe PMC40
2010 Yool, A., Brown, E., & Flynn, G. (2010). Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clinical and Experimental Pharmacology and Physiology, 37(4), 403-409.
DOI Scopus71 WoS66 Europe PMC58
2010 Devuyst, O., & Yool, A. (2010). Aquaporin-1: New developments and perspectives for peritoneal dialysis. Peritoneal Dialysis International, 30(2), 135-141.
DOI Scopus25 WoS25 Europe PMC14
2009 Migliati, E., Meurice, N., Dubois, P., Fang, J., Somasekharan, S., Spencer, E., . . . Yool, A. (2009). Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Molecular Pharmacology, 76(1), 105-112.
DOI Scopus155 WoS145 Europe PMC125
2009 Baetz, N., Hoffman, E., Yool, A., & Stamer, W. (2009). Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Experimental Eye Research, 89(1), 95-100.
DOI Scopus40 WoS33 Europe PMC36
2009 Yool, A. J., Brown, E. A., & Flynn, G. A. (2009). Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clin Exp Pharmacol Physiol, 37(4), 403-409.
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2008 Falk, T., Xie, J. Y., Zhang, S., Kennedy, J., Bennett, J., Yool, A. J., & Sherman, S. J. (2008). Over-expression of the potassium channel Kir2.3 using the dopamine-1 receptor promoter selectively inhibits striatal neurons. Neuroscience, 155(1), 114-127.
DOI Scopus13 WoS14 Europe PMC11
2007 Yool, A. (2007). Functional domains of aquaporin-1: Keys to physiology and targets for drug discovery. Current Pharmaceutical Design, 13(31), 3212-3221.
DOI Scopus46 WoS42 Europe PMC35
2007 Yool, A. (2007). Aquaporins: Multiple roles in the central nervous system. Neuroscientist, 13(5), 470-485.
DOI Scopus89 WoS81 Europe PMC63
2006 Boassa, D., Stamer, W., & Yool, A. (2006). Ion channel function of aquaporin-1 natively expressed in choroid plexus. Journal of Neuroscience, 26(30), 7811-7819.
DOI Scopus94 WoS88 Europe PMC82
2006 Yu, J., Yool, A., Schulten, K., & Tajkhorshid, E. (2006). Mechanism of gating and ion conductivity of a possible tetrameric pore in Aquaporin-1. Structure, 14(9), 1411-1423.
DOI Scopus149 WoS141 Europe PMC116
2006 Yool, A. (2006). Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain. Gene Expression, 13(6), 329-337.
DOI Scopus8 WoS7 Europe PMC7
2005 Boassa, D., & Yool, A. (2005). Physiological roles of aquaporins in the choroid plexus. Current Topics in Developmental Biology, 67, 181-206.
DOI Scopus35 WoS34 Europe PMC33
2004 Yool, A., & Stamer, W. (2004). Novel roles for aquaporins as gated ion channels. Advances in Molecular and Cell Biology, 32, 351-379.
DOI Scopus6
2004 Yanochko, G., & Yool, A. (2004). Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes. Biophysical Journal, 86(3), 1470-1478.
DOI Scopus19 WoS18 Europe PMC20
2003 Falk, T., Kilani, R., Strazdas, L., Borders, R., Steidl, J., Yool, A., & Sherman, S. (2003). Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvß1.1 subunit. Neuroscience, 120(2), 387-404.
DOI Scopus16 WoS16 Europe PMC16
2003 Boassa, D., & Yool, A. (2003). Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation. BMC Physiology, 3(Article 1), 1-13.
DOI Scopus39 Europe PMC34
2002 Yool, A., & Weinstein, A. (2002). New roles for old holes: Ion channel function in aquaporin-1. Physiology, 17(2), 68-72.
DOI Scopus104 WoS97 Europe PMC80
2002 Anthony, T., Fujino, H., Pierce, K., Yool, A., & Regan, J. (2002). Differential regulation of Ca²⁺-dependent Cl⁻ currents by FP prostanoid receptor isoforms in Xenopus oocytes. Biochemical Pharmacology, 63(10), 1797-1806.
DOI Scopus6 WoS5 Europe PMC4
2002 Yool, A., Brokl, O., Pannabecker, T., Dantzler, W., & Stamer, W. (2002). Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line. BMC Physiology, 2(1), 1-8.
DOI Scopus65 Europe PMC61
2002 Yanochko, G., & Yool, A. (2002). Regulated cationic channel function in Xenopus oocytes expressing Drosophila big brain. Journal of Neuroscience, 22(7), 2530-2540.
DOI Scopus66 WoS64 Europe PMC53
2002 Boassa, D., & Yool, A. (2002). A fascinating tail: cGMP activation of aquaporin-1 ion channels. Trends in Pharmacological Sciences, 23(12), 558-562.
DOI Scopus48 WoS43 Europe PMC38
2001 Steidl, J., & Yool, A. (2001). Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds. Biophysical Journal, 81(5), 2606-2613.
DOI Scopus11 WoS11 Europe PMC7
2001 Falk, T., Strazdas, L., Borders, R., Kilani, R., Yool, A., & Sherman, S. (2001). A herpes simplex viral vector expressing green fluorescent protein can be used to visualize morphological changes in high-density neuronal culture. Electronic Journal of Biotechnology, 4(1), 33-45.
Scopus2
2001 Falk, T., Kilani, R., Yool, A., & Sherman, S. (2001). Viral vector-mediated expression of K+ channels regulates electrical excitability in skeletal muscle. Gene Therapy, 8(18), 1372-1379.
DOI Scopus10 WoS12 Europe PMC9
2000 Muller, Y. L., Reitstetter, R., & Yool, A. J. (2000). Antisense knockdown of calcium-dependent K+ channels in developing cerebellar Purkinje neurons. Developmental Brain Research, 120(2), 135-140.
DOI Scopus8 WoS8 Europe PMC7
2000 Anthony, T. L., Brooks, H. L., Boassa, D., Leonov, S., Yanochko, G. M., Regan, J. W., & Yool, A. J. (2000). Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. Molecular Pharmacology, 57(3), 576-588.
DOI Scopus166 WoS154 Europe PMC127
2000 Brooks, H. L., Regan, J. W., & Yool, A. J. (2000). Inhibition of aquaporin-1 water permeability by tetraethylammonium: Involvement of the loop E pore region. Molecular Pharmacology, 57(5), 1021-1026.
DOI Scopus131 WoS110 Europe PMC84
1999 Falk, T., Garver, W. S., Erickson, R. P., Wilson, J. M., & Yool, A. J. (1999). Expression of Niemann-Pick type C transcript in rodent cerebellum in vivo and in vitro. Brain Research, 839(1), 49-57.
DOI Scopus21 WoS20 Europe PMC16
1999 Falk, T., Muller, Y. L., & Yool, A. J. (1999). Differential expression of three classes of voltage-gated Ca2+ channels during maturation of the rat cerebellum in vitro. Developmental Brain Research, 115(2), 161-170.
DOI Scopus13 WoS12 Europe PMC8
1999 Steidl, J. V., & Yool, A. J. (1999). Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor. Molecular Pharmacology, 55(5), 812-820.
DOI Scopus74 WoS71 Europe PMC58
1998 Muller, Y. L., & Yool, A. J. (1998). Increased calcium-dependent K+ channel activity contributes to the maturation of cellular firing patterns in developing cerebellar Purkinje neurons. Developmental Brain Research, 108(1-2), 193-203.
DOI Scopus20 WoS17 Europe PMC16
1998 Reitstetter, R., & Yool, A. J. (1998). Morphological consequences of altered calcium-dependent transmembrane signaling on the development of cultured cerebellar Purkinje neurons. Developmental Brain Research, 107(1), 165-167.
DOI Scopus10 WoS9 Europe PMC8
1998 Li Muller, Y., Reitstetter, R., & Yool, A. J. (1998). Regulation of Ca2+ -dependent K+ channel expression in rat cerebellum during postnatal development. Journal of Neuroscience, 18(1), 16-25.
DOI Scopus51 WoS48 Europe PMC43
1998 Jacquin, T. D., Yool, A., Benoit, E., Spitzer, N. C., & Moody, W. J. (1998). Firing and wiring of excitable cells during maturation: the rationale for rhythm. M S-MEDECINE SCIENCES, 14(1), 63-71.
DOI WoS1
1998 Sutherland, V., Sutherland, G., Tucker, V. A., Lynch, R., & Yool, A. (1998). Glucose sensing by neurons isolated from the hypothalamus. FASEB Journal, 12(5), A747.
1998 Yool, A., Benoît, E., Spitzer, N. C., & Moody, W. J. (1998). Petites cellules excitables deviendront grandes : le rythme pour la raison. Medecine/Sciences, 14(1), 63-71.
DOI Scopus1
1997 Agre, P., Lee, M. D., Devidas, S., Guggino, W. B., Sasaki, S., Uchida, S., . . . Yool, A. J. (1997). Aquaporins and ion conductance. Science, 275(5305), 1490-1492.
DOI Scopus87 WoS1 Europe PMC15
1996 Pierce, K., Yool, A., Moyer, P., Gil, D., Woodward, D., & Regan, J. (1996). Cloning of a novel isoform of the sheep FP prostaglandin receptor. Proceedings of the Western Pharmacology Society, 39, 104.
1996 Steidl, J. V., & Yool, A. J. (1996). Molecular mechanisms of action of a class III antiarrhythmic. FASEB Journal, 10(3), A32.
1996 Yool, A. J., Stamer, W. D., & Regan, J. W. (1996). Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. Science, 273(5279), 1216-1218.
DOI Scopus162 WoS159 Europe PMC123
1996 Yool, A. J., & Schwarz, T. L. (1996). Anomalous mole fraction effect induced by mutation of the H5 pore region in the Shaker K+ channel. Biophysical Journal, 71(5), 2467-2472.
DOI Scopus10 WoS10 Europe PMC7
1995 Graves, P. E., Pierce, K. L., Bailey, T. J., Rueda, B. R., Gil, D. W., Woodward, D. F., . . . Regan, J. W. (1995). Cloning of a receptor for prostaglandin F2α from the ovine corpus luteum. Endocrinology, 136(8), 3430-3436.
DOI Scopus66 Europe PMC38
1995 Yool, A. J., & Schwarz, T. L. (1995). Interactions of the H5 pore region and hydroxylamine with N-type inactivation in the Shaker K+ channel. Biophysical Journal, 68(2), 448-458.
DOI Scopus15 WoS16 Europe PMC12
1995 GRAVES, P. E., PIERCE, K. L., BAILEY, T. J., RUEDA, B. R., GIL, D. W., WOODWARD, D. F., . . . REGAN, J. W. (1995). CLONING OF A RECEPTOR FOR PROSTAGLANDIN-F2-ALPHA FROM THE OVINE CORPUS-LUTEUM. ENDOCRINOLOGY, 136(8), 3430-3436.
DOI WoS62
1994 Yool, A. J. (1994). Block of the inactivating potassium channel by clofilium and hydroxylamine depends on the sequence of the pore region. Molecular Pharmacology, 46(5), 970-976.
DOI Scopus8 WoS8 Europe PMC7
1992 SCHWARZ, T. L., & YOOL, A. J. (1992). THE MOLECULAR-BIOLOGY OF POTASSIUM CHANNELS AND MUTATIONS THAT ALTER THE SELECTIVITY OF THE PORE. NEUROTOX 91, 165-177.
1992 Yool, A. J., Krieger, R. M., & Gruol, D. L. (1992). Multiple ionic mechanisms are activated by the potent agonist quisqualate in cultured cerebellar Purkinje neurons. Brain Research, 573(1), 83-94.
DOI Scopus13 WoS15 Europe PMC12
1992 Gruol, D. L., Deal, C. R., & Yool, A. J. (1992). Developmental changes in calcium conductances contribute to the physiological maturation of cerebellar purkinje neurons in culture. Journal of Neuroscience, 12(7), 2838-2848.
DOI Scopus53 WoS56 Europe PMC48
1991 Yool, A. J., & Schwarz, T. L. (1991). Alteration of ionic selectivity of a K+ channel by mutation of the H5 region. Nature, 349(6311), 700-704.
DOI Scopus361 WoS376 Europe PMC275
1991 Gruol, D. L., Jacquin, T., & Yool, A. J. (1991). Single-channel K+ currents recorded from the somatic and dendritic regions of cerebellar purkinje neurons in culture. Journal of Neuroscience, 11(4), 1002-1015.
DOI Scopus49 WoS52 Europe PMC41
1990 Van Gelder, R. N., Von Zastrow, M. E., Yool, A., Dement, W. C., Barchas, J. D., & Eberwine, J. H. (1990). Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proceedings of the National Academy of Sciences of the United States of America, 87(5), 1663-1667.
DOI Scopus1078 WoS940 Europe PMC823
1989 Gruol, D. L., Dionne, V. E., & Yool, A. J. (1989). Multiple voltage-sensitive K+ channels regulate dendritic excitability in cerebellar Purkinje neurons. Neuroscience Letters, 97(1-2), 97-102.
DOI Scopus13 WoS18 Europe PMC12
1989 Joels, M., Yool, A. J., & Gruol, D. L. (1989). Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured Purkinje neurons. Proceedings of the National Academy of Sciences of the United States of America, 86(9), 3404-3408.
DOI Scopus30 WoS32 Europe PMC18
1988 Yool, A. J., Dionne, V. E., & Gruol, D. L. (1988). Developmental changes in K+-selective channel activity during differentiation of the Purkinje neuron in culture. Journal of Neuroscience, 8(6), 1971-1980.
DOI Scopus49 WoS62 Europe PMC49
1988 Yool, A. J., Gruol, D. L., & Dionne, V. E. (1988). Voltage-sensitive K+ channels contribute to dendritic excitability in cerebellar Purkinje neurons.. Symposia in Neuroscience, 6, 57-68.
1987 Yool, A. J., & Gruol, D. L. (1987). Development of spontaneous and glutamate-evoked activity is altered by chronic ethanol in cultured cerebellar Purkinje neurons. Brain Research, 420(2), 205-219.
DOI Scopus27 WoS30 Europe PMC24
1986 YOOL, A. J., GRAU, S. M., HADFIELD, M. G., JENSEN, R. A., MARKELL, D. A., & MORSE, D. E. (1986). EXCESS POTASSIUM INDUCES LARVAL METAMORPHOSIS IN 4 MARINE INVERTEBRATE SPECIES. BIOLOGICAL BULLETIN, 170(2), 255-266.
DOI WoS151
1984 BALOUN, A. J., & MORSE, D. E. (1984). IONIC CONTROL OF SETTLEMENT AND METAMORPHOSIS IN LARVAL HALIOTIS-RUFESCENS (GASTROPODA). BIOLOGICAL BULLETIN, 167(1), 124-138.
DOI WoS138
1980 Morse, D. E., Duncan, H., Hooker, N., Baloun, A., & Young, G. (1980). GABA induces behavioral and developmental metamorphosis in planktonic molluscan larvae. Fed Proc, 39(14), 3237-3241.

Year Citation
2016 Pei, J., Ameliorate, J., Kourghi, M., De Ieso, M., & Yool, A. (2016). Drug Discovery and Therapeutic Targets for Pharmacological Modulators of Aquaporin Channels. In G. Soveral, S. Nielsen, & A. Casini (Eds.), Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery (pp. 273-296). Boca Raton, FL: CRC Press.
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2008 Stamer, W., Baetz, N., & Yool, A. (2008). Ocular aquaporins and aqueous humor dynamics. In The Eye's Aqueous Humor (Vol. 62, 2 ed., pp. 47-70). San Diego, California: Elsevier.
DOI Scopus8 WoS7

Year Citation
2021 Khan, S., Yool, A., & Ricciardelli, C. (2021). EXPRESSION OF AQUAPORINS IN HUMAN ENDOMETRIAL CANCER: IDENTIFICATION AND REGULATION BY OVARIAN HORMONES IN CARCINOGENESIS OF ENDOMETRIAL CANCER. In INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 31 (pp. A75). BMJ PUBLISHING GROUP.
DOI
2020 Montiel, V., Bella, R., Michel, L., Robinson, E., Jonas, J. C., Michel, T., . . . Balligand, J. L. (2020). Inhibition of the water channel aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. In EUROPEAN HEART JOURNAL Vol. 41 (pp. 3665). ELECTR NETWORK: OXFORD UNIV PRESS.
2015 Tomita, Y., Dorward, H., Wrin, J., Vary, R. J., De Ieso, M. L., Yool, A. J., . . . Hardingham, J. E. (2015). The effect of aquaporin-5 knockdown on HT29 colon cancer cell proliferation and migration. In ANNALS OF ONCOLOGY Vol. 26 (pp. 4). Singapore, SINGAPORE: OXFORD UNIV PRESS.
2004 Migliati, E. R., Ritter, L., & Yool, A. J. (2004). A strategy for drug discovery for cerebral oedema after stroke. In JOURNAL OF NEUROLOGY Vol. 251 (pp. 58). Barcelona, SPAIN: DR DIETRICH STEINKOPFF VERLAG.
2004 Falk, T., Erbe, E. L., Yool, A. J., & Shermann, S. J. (2004). Neurochemical and electrophysiological characterization of cultured rat striatal neurons as a model system for gene therapy.. In BIOPHYSICAL JOURNAL Vol. 86 (pp. 270A). Baltimore, MD: BIOPHYSICAL SOCIETY.
2003 Falk, T., Kumar, A., Yool, A. J., & Carnevale, N. T. (2003). Modeling overexpression of different K<SUP>+</SUP> channels in myotubes. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 420A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Birdsell, D. N., & Yool, A. J. (2003). Regulation of cGMP-gated conductance and water permeability of Aqp1 channels by the carboxyl terminal domain.. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 400A-401A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Kruer, M. C., Erbe, E. L., Yool, A. J., & Sherman, S. J. (2003). Changes in the expression of EF-hand calcium binding proteins in rat fetal hippocampal neurons treated with basic fibroblast growth factor and neurotrophin-3.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 51 (pp. S110). CARMEL, CALIFORNIA: B C DECKER INC.
2002 Boassa, D., & Yool, A. J. (2002). Contribution of single amino acids in the carboxyl terminal domain of Aquaporin-1 channels to cGMP-dependent activation. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 275A). BIOPHYSICAL SOCIETY.
2002 Yool, A. J. (2002). Block by divalent cations of the cyclic-GMP-gated ionic conductance in human Aquaporin-1 channels. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 275A). BIOPHYSICAL SOCIETY.
WoS1
2002 Birdsell, D. N., & Yool, A. J. (2002). Voltage dependence of tea block of osmotic water permeability in Aquaporin 1 channels. In BIOPHYSICAL JOURNAL Vol. 82 (pp. 274A-275A). BIOPHYSICAL SOCIETY.
2001 Yool, A. J., & Boassa, D. (2001). Cyclic-GMP-dependent activation of Aquaporin-1 ion channels.. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 102A). BIOPHYSICAL SOCIETY.
2001 Boassa, D., & Yool, A. (2001). Voltage-sensitive rate of activation of aquaporin-1 channels by cGMP.. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 633A). BIOPHYSICAL SOCIETY.
2001 Falk, T., Kilani, R. K., Yool, A. J., & Sherman, S. J. (2001). Viral-vector-mediated expression of K<SUP>+</SUP> channels regulates electrical excitability in skeletal muscle. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 648A). BIOPHYSICAL SOCIETY.
WoS1
2001 Yanochko, G. M., & Yool, A. J. (2001). Cation permeability and divalent cation block of big brain channels. In BIOPHYSICAL JOURNAL Vol. 80 (pp. 204A). BIOPHYSICAL SOCIETY.
2000 Anthony, T. L., Pujino, H., Pierce, K. L., Yool, A. J., & Regan, J. W. (2000). Differential activation of Ca<SUP>2+</SUP>-dependent Cl<SUP>-</SUP> currents by FP prostanoid receptor isoforms in <i>Xenopus</i> oocytes.. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 41 (pp. S250). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
2000 Yanochko, G. M., Vaillancourt, R. R., Regan, J. W., & Yool, A. J. (2000). The MIP-related channel, big brain is regulated by tyrosine phosphorylation in Xenopus oocytes.. In FASEB JOURNAL Vol. 14 (pp. A344). FEDERATION AMER SOC EXP BIOL.
2000 Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In FASEB JOURNAL Vol. 14 (pp. A71). FEDERATION AMER SOC EXP BIOL.
2000 Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 183A). LIPPINCOTT WILLIAMS & WILKINS.
2000 Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (2000). Expression of a potassium channel-reporter gene fusion protein in cultured rat skeletal myocytes.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 87A). LIPPINCOTT WILLIAMS & WILKINS.
2000 Borders, R. J., Falk, T., Strazdas, L. A., Yool, A. J., & Sherman, S. J. (2000). Modulation of potassium channel inactivation by antisense knockdown of the β1 subunit.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 48 (pp. 77A). LIPPINCOTT WILLIAMS & WILKINS.
2000 Yool, A. J., Boassa, D., Anthony, T. L., & Regan, J. W. (2000). Mechanisms of activation of aquaporin-1 ion channel function. In FASEB JOURNAL Vol. 14 (pp. A344). FEDERATION AMER SOC EXP BIOL.
1999 Brooks, H. L., Regan, J. W., & Yool, A. J. (1999). Inhibition of aquaporin-1 water permeability by TEA.. In FASEB JOURNAL Vol. 13 (pp. A394). FEDERATION AMER SOC EXP BIOL.
WoS3
1999 Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel -reporter gene fusion protein in cultured hippocampal neurons. In Journal of Investigative Medicine Vol. 47 (pp. 34). SLACK INC.
1999 Kilani, R. K., Faik, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel-reporter gene fusion protein in cultured hippocampal neurons.. In FASEB JOURNAL Vol. 13 (pp. A472). FEDERATION AMER SOC EXP BIOL.
1999 Kilani, R. K., Falk, T., Yool, A. J., & Sherman, S. J. (1999). Expression of a potassium channel-reporter gene fusion protein in cultured hippocampal neurons.. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 47 (pp. 196A). SLACK INC.
1999 Sherman, S. J., Falk, T., Borders, R. J., Srazdas, L. A., & Yool, A. J. (1999). Viral vector-mediated trans-gene expression of an antisense sequence targeting knockdown of the β<sub>1.1</sub>-subunit of the K<sub>V</sub>1 voltage-gated potassium channels in cultured hippocampal neurons.. In EPILEPSIA Vol. 40 (pp. 11). LIPPINCOTT WILLIAMS & WILKINS.
1999 Sutherland, V., Murphy, S., Yool, A., & Lynch, R. (1999). Bimodal responses of cultured hypothalamic neurons.. In FASEB JOURNAL Vol. 13 (pp. A748). FEDERATION AMER SOC EXP BIOL.
1997 Lynch, R. M., Tucker, V. A., Sutherland, G., & Yool, A. (1997). Mechanisms of glucose sensing by neurons of the hypothalamus.. In FASEB JOURNAL Vol. 11 (pp. 3624). FEDERATION AMER SOC EXP BIOL.
1996 Pierce, K. L., Yool, A. J., Woodward, D. F., Gil, D. W., & Regan, J. W. (1996). Second messenger coupling of two FP prostanoid receptor carboxy terminal isoforms. In MOLECULAR BIOLOGY OF THE CELL Vol. 7 (pp. 3458). AMER SOC CELL BIOLOGY.
1996 Stamer, W. D., Regan, J. W., & Yool, A. J. (1996). Calcium influences water and cation fluxes in Xenopus oocytes expressing aquaporin-1. In MOLECULAR BIOLOGY OF THE CELL Vol. 7 (pp. 1488). AMER SOC CELL BIOLOGY.
1988 GRUOL, D. L., & YOOL, A. J. (1988). IDENTIFICATION OF K+ CHANNEL TYPES MEDIATING SPIKE EVENTS IN CEREBELLAR PURKINJE NEURONS. In BIOPHYSICAL JOURNAL Vol. 53 (pp. A458). BIOPHYSICAL SOCIETY.
WoS1
1986 YOOL, A. J., & GRUOL, D. L. (1986). CHRONIC ETHANOL ALTERS THE SPONTANEOUS ACTIVITY OF DEVELOPING PURKINJE NEURONS IN CULTURE. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 10 (pp. 121). WILLIAMS & WILKINS.
1985 YOOL, A. J., & MORSE, D. E. (1985). IONIC CONTROL OF METAMORPHOSIS IN GASTROPOD LARVAE. In AMERICAN ZOOLOGIST Vol. 25 (pp. 287). AMER SOC ZOOLOGISTS.

Year Citation
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). EPV114/# 325 Expression of aquaporins in human endometrial cancer: identification and regulation by ovarian hormones in carcinogenesis of endometrial cancer. Poster session presented at the meeting of International gynaecological cancer society.
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells.. Poster session presented at the meeting of EMBL Australia.
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Metastasis Research Society (OzMRS).
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Physiological society (AuPS) (oral presentation).
2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Identification of Aquaporins in human endometrial cancer and regulation by ovarian hormones in carcinogenesis.. Poster session presented at the meeting of The Australian Society for Medical Research National Scientific Conference, Adelaide, Australia..
2020 Nourmohammadi, S., & Yool, A. (2020). (Oral presentation) Discovering New Cancer-linked Ion Channels using a Photoswitchable Lithium Porbe. Poster session presented at the meeting of 3-minutes talk competition, The Institute for Photonics and Advanced Sensing (IPAS). University of Adelaide.
2019 Nourmohammadi, S., Nwe Aung, T., Cui, J., Pei, J., De leso, M., Qu, Z., . . . Yool, A. (2019). (Oral presentation) Systematic dissection of the molecular actions of compounds from traditional medicinal mixtures on the migration, invasion and apoptosis of brain, bowel and breast cancer cells. Poster session presented at the meeting of AuPS/ABS Meeting, Canberra, 2019.
2019 Nourmohammadi, S., Yool, A., & Adelson, D. (2019). (Poster presentation) Natural Compounds as Potential Anti-metastatic Treatments for Brain, Bowel and Breast Cancer. Poster session presented at the meeting of Florey Postgraduate Conference.
2018 Pei, J. V., Heng, S., De Ieso, M., Sylvia, G., Kourghi, M., Abell, A. D., & Yool, A. J. (2018). Real-Time Imaging of Lithium 'Hot-Spots': An Analysis of Ion Conductance in Aquaporin-1 using Novel Photo-Switchable Sensor. Poster session presented at the meeting of BIOPHYSICAL JOURNAL. San Francisco, CA: CELL PRESS.
2018 Nourmohammadi, S., Nwe Aung, T., Yool, A., & Adelson, D. (2018). (Poster presentation) Fractional Deletion of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical for Its Perturbation of The Cell Cycle. Poster session presented at the meeting of Florey Postgraduate Conference.
2018 Nourmohammadi, S., Yool, A., & Adelson, D. (2018). (Poster presentation) Discovery of the Anti-metastasic Activity of a Chinese medicinal herb mixture 'Compound Kushen Injection' and Identification of the Active Components in Brain, Colon and Breast Cancer Cell Lines. Poster session presented at the meeting of Australian Society for Medical Research (ASMR).
2018 Palethorpe, H. M., Tomita, Y., Smith, E., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Bacopaside II reduces endothelial cell migration and angiogenesis in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne.
2018 Smith, E., Palethorpe, H. M., Tomita, Y., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Anti-tumour effects of Bacopaside II on colorectal cancer cells in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne, VIC.
2017 Nourmohammadi, S., Pie, V. J., Kourghi, M., De leso, M. L., Pak, C., Adelson, D. L., & Yool, A. J. (2017). (Oral presentation) Analysis of effective compounds and mechanisms of action of a Chinese traditional herbal medicine (Compound Kushen Injection) on aquaporins involved in cancer cell migration and metastasis.. Poster session presented at the meeting of Gage Ion Channels and Transporters Conference. Canberra, Australia.
2016 Byrt, C. S., Zhao, M., Kourghi, M., Bose, J., Henderson, S. W., Qui, J., . . . Tyerman, S. (2016). Charging up water transport with plant aquaporins permeable to ions. Poster session presented at the meeting of Combio2016. Brisbane, Australia.
2014 Eden, G., Lampton, L., Cheah, K., Lymn, K., Bajic, J., Yool, A., & Howarth, G. (2014). Aqueous rhubarb extract improves ileal mucosal integrity and reduces acute inflammation in a rat model of 5-fluorouracil-induced intestinal mucositis. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Broadbeach, Qld.: Wiley.
DOI
2013 Pei, J., Campbell, E. M., & Yool, A. J. (2013). Inhibition of aquaporin-1 but not aquaporin-4 water permeability by bacopaside I derived from <i>Bacopa monnieri</i>. Poster session presented at the meeting of PLANTA MEDICA. GEORG THIEME VERLAG KG.
2012 Klebe, S., Griggs, K., Henderson, D. W., & Yool, A. J. (2012). MODULATION OF AQUAPORIN 1 AS A NOVEL TREATMENT STRATEGY FOR MALIGNANT MESOTHELIOMA. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. Adelaide, AUSTRALIA: ELSEVIER SCIENCE INC.
DATE CURRENT GRANTS  Investigators Funding Agency
2026-2028 Identification of the biological targets for novel drugs that block glioblastoma invasiveness

S Ramesh

AJ Yool

 Flinders University competitive Seed Grant funding
2022-2025 Investigation the influence of wine macromolecules on aquaporin function and implications for taste signalling

AJ Yool

D Espinase Nandorfy

 Australian Wine Research Institute / UoA Collaborative Research Investment Fund
2022-2024 Testing combined therapies as a powerful tool for controlling paediatric Glioblastoma multiforme invasiveness

SA Ramesh

AJ Yool

R Haberberger

 Children's Research Foundation Ch 7, Australia
2022-2023

Developing novel therapeutic candidates for limiting invasive capabilities of Glioblastoma multiforme cells

SA Ramesh

AJ Yool

RA Davis

 NeuroSurgical Research Foundation, Australia

PRIOR FUNDING

Date Title Investigators Funding Agency
2019-2021 Fundamental roles of Aquaporin-1 channels in cellular migration and morphology (DP190101745) AJ Yool and S Ramesh Australian Research Council (ARC)
2019-2021 Channels for improved crop salt and water stress tolerance (DP190102725) C Byrt, S Tyerman, AJ Yool, F Chaumont and M Tester Australian Research Council (ARC)
2020-2022 Developing an animal-free analysis platform to assess human Aquaporin-1 channels involved in cancer cell migration. S Henderson, AJ Yool, B Martinac Medical Advances Without Animals
2016- 2018 Properties enabling rapid cell migration by aquaporin-1 channel expression  (DP160104641) Yool Australian Research Council (ARC)
2015 Characterisation of aquaporin-1 (AQP1) ion channel activity in migrating cancer cells using a novel photoswitchable fluorescent probe Yool Institute for Photonics & Advanced Sensing
2011 Aquaporin physiology and drug discovery Yool Adelaide Centre for Neuroscience Research
2010 Role of Aquaporins in mesothelioma Klebe,Yool Flinders Medical Research Foundation
2010 Cloning the Neoparameoba aquaporin channel as a target for parasite control in finfish Cook, Yool CRC Seafood Research Foundation
2010 Role of the brain water channel aquaporin-4 in development and epilepsy Yool Children’s Research Foundation Channel7
2009 Water and ion channel blocking activity of novel neurological agents Yool Neurotherapeutics, Chicago IL USA
2009 The effects of novel aquaporin 4 channel blockers on reducing post stroke edema Chen, Yool Ramaciotti foundation
2006 - 09 Development of novel blockers of Aquaporin-4 channels with translational relevance to stroke-induced brain edema Yool BIO5 Pilot grant, AZ USA
2004 - 09 Predoctoral Training Program in Neuroscience (NIH T321 007434-07) Yool National Institutes of Health (NIH), USA
2003 - 07 Structural basis of ion channel function in Aquaporin-1 (NIH-R01-GM59986) Yool National Institutes of Health (NIH), USA

Current teaching contributions:

Cellular & Systems Neurobiology 

  • BMS Year 3 Research Skills Development 

College of Health Honours Research 

Introduction to Health Research

 

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* primary instructor and course coordinator

 

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor Novel Monitoring of Membrane Electrical Responses in Glioblastoma Cells Using Voltage-Sensitive Dye BeRST 1 for Invasion Inhibition Research Doctor of Philosophy Doctorate Full Time Ms Shijin Suo
2025 Principal Supervisor Novel Monitoring of Membrane Electrical Responses in Glioblastoma Cells Using Voltage-Sensitive Dye BeRST 1 for Invasion Inhibition Research - Doctorate Full Time Ms Shijin Suo
2025 Principal Supervisor Novel Monitoring of Membrane Electrical Responses in Glioblastoma Cells Using Voltage-Sensitive Dye BeRST 1 for Invasion Inhibition Research Doctor of Philosophy Doctorate Full Time Ms Shijin Suo
2022 Principal Supervisor Characterization of Drugs Modulating the Aquaporin Channel Activity to Inhibit Angiogenesis and Metastasis Doctor of Philosophy Doctorate Full Time Ms Kim Kristin Wagner
2022 Principal Supervisor Characterization of Drugs Modulating the Aquaporin Channel Activity to Inhibit Angiogenesis and Metastasis - Doctorate Full Time Ms Kim Kristin Wagner

Date Role Research Topic Program Degree Type Student Load Student Name
2021 - 2023 Principal Supervisor Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels Master of Philosophy (Medical Science) Master Full Time Ms Alanah Varricchio
2020 - 2024 Principal Supervisor Developing Novel Conservative Treatments For Endometrial Cancer By Targeting Aquaporin-1 Doctor of Philosophy Doctorate Full Time Ms Sidra Nawaz Khan
2020 - 2023 Principal Supervisor Discovery of novel aquaporin subtypes in the human brain: Potential relevance of peroxiporins AQP0 and AQP11 to cellular stress and Alzheimer’s Disease Doctor of Philosophy Doctorate Full Time Mr Zein Alabedyn Amro
2018 - 2022 Co-Supervisor Bt toxins: using flies, moths, and oocytes to unravel a complex mode of action Doctor of Philosophy Doctorate Full Time Mr Biko Kahare Muita
2018 - 2023 Principal Supervisor Aquaporins - from Ion Channels to Human Cancers Doctor of Philosophy Doctorate Full Time Mr Saeed Nourmohammadi
2016 - 2022 Principal Supervisor Role of Aquaporin 1 in Diseases and Drug Discovery Doctor of Philosophy Doctorate Full Time Mr Pak Hin Chow
2015 - 2021 Co-Supervisor Evaluation of Anti-Cancer Effect of Synthetic and Plant-based Inhibitors of Aquaporin 1 in Colon Cancer Doctor of Philosophy Doctorate Part Time APrf Yoko Tomita
2015 - 2019 Principal Supervisor Pharmacological Modulation of Cancer Migration and Invasion Through Targeting AQP1 Ion and Water Channel Activity Doctor of Philosophy Doctorate Full Time Michael Lucio De Ieso
2013 - 2017 Co-Supervisor A Clarification of the Aetiology and Pathogenesis of Renal Tubular Epithelial Cell Vacuolization in Diabetic Ketoacidosis Doctor of Philosophy Doctorate Part Time Chong Zhou
2013 - 2018 Principal Supervisor A Comparative Study of Physiological and Modulators of Aquaporin ion Channels in Diverse Phyla Doctor of Philosophy Doctorate Full Time Mohamad Kourghi
2012 - 2014 Co-Supervisor AQUAPORINS: GATEKEEPERS OF OEDEMA IN TRAUMATIC BRAIN INJURY Doctor of Philosophy Doctorate Full Time Dr Joshua Luke Burton
2011 - 2016 Co-Supervisor Evaluation of Indices of Affective State in a Rat Model of Chemotherapy-induced Mucositis Doctor of Philosophy Doctorate Part Time APrf Alexandra Whittaker
2011 - 2017 Principal Supervisor Aquaporin in Cancer Cell Migration: Discovery of New Pharmacological Blockers and a Novel Lithium Sensor Doctor of Philosophy Doctorate Full Time Dr Jinxin Pei
2009 - 2010 Principal Supervisor Towards Gene Therapy for Cystic Fibrosis Airway Disease: Development of a Single-Dose Lentiviral Gene Transfer for Lifetime Airway Expression Doctor of Philosophy Doctorate Part Time Ms Alice Stocker
2008 - 2008 Principal Supervisor Characterisation of a Dominant Negative Androgen Receptor in Prostate Cancer Cells Doctor of Philosophy Doctorate Part Time Dr Margaret Centenera

Date Role Membership Country
2008 - ongoing Member Australian Physiology Society Australia
2007 - ongoing Member Australian Society for Biophysics Australia
2006 - ongoing Member Member of Evelyn McKnight Brain Institute United States
2002 - ongoing Member American Society for Pharmacology and Experimental Therapeutics United States

Date Role Editorial Board Name Institution Country
2020 - ongoing Board Member Associate Editor, Frontiers in Pharmacology Frontiers Switzerland

Date Title Type Institution Country
2019 - 2022 ARC College of Experts member (2019-2022) Grant Assessment Australian Research Council -

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