Rui Chen

Rui Chen

School of Chemical Engineering

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr Rui Chen (Richard) is a postdoctoral research fellow in the School of Chemical Engineering and Advanced Materials at the University of Adelaide. His research work is primarily funded by a CRC-P grant project "mRNA manufacturing and formulation service for late-stage clinical trials", where he contributes to assessment of mRNA lipid nanoparticle (LNP) quality, evaluation of nano-formulation stability, optimization of mRNA LNP bioprocessing, and development of ready-to-inject liquid aqueous preparations that can be stored at 5 +/- 3 degrees Celsius.
With a doctoral degree in chemistry and a postdoctoral study in cancer immunotherapy, Dr. Rui Chen has expertise in designing nanomaterial for cancer-targeted drug/gene delivery, validating drug/gene delivery systems in vitro, and evaluating cancer therapeutics for immunotherapy in vivo. His research focuses on development of applicable therapeutic strategies and clinical translation of nano-biomedicine for gene delivery and cancer immunotherapy.

  • Appointments
    Date Position Institution name
    2023 - ongoing Postdoctoral research fellow The University of Adelaide
    2019 - 2022 Postdocotral research fellow University of Queensland
    2017 - 2018 Research associate City University of Hong Kong

  • Education
    Date Institution name Country Title
    2014 - 2017 City University of Hong Kong Hong Kong PhD

  • Research Interests
    Cancer Therapy Immunology Nanomedicine

  • Journals
    Year Citation
    2025 Lan, Z., Chen, R., Zou, D., & Zhao, C. -X. (2025). Microfluidic Nanoparticle Separation for Precision Medicine. Advanced Science, 12(4), 2411278-1-2411278-38.
    DOI Europe PMC2
    2025 Chen, R., Bhavsar, C., Lourie, R., Li, S., & Wu, S. Y. (2025). Development of an innovative extracellular vesicle mimetic delivery platform for efficient miRNA delivery to tumours. Biomaterials, 321, 123282.
    DOI
    2024 Wilkinson, A. N., Chen, R., Coleborn, E., Neilson, T., Le, K., Bhavsar, C., . . . Wu, S. Y. (2024). Let-7i enhances anti-tumour immunity and suppresses ovarian tumour growth. Cancer Immunology Immunotherapy, 73(5), 80-1-80-12.
    DOI Europe PMC2
    2023 Chen, R., Coleborn, E., Bhavsar, C., Wang, Y., Alim, L., Wilkinson, A. N., . . . Wu, S. Y. (2023). miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+T cell infiltration. Molecular Therapy: Oncolytics, 31, 100725-1-100725-15.
    DOI Europe PMC8
    2019 Zhang, J., Nie, W., Chen, R., Chelora, J., Wan, Y., Cui, X., . . . Lee, C. -S. (2019). Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy.. Nano letters, 19(2), 658-665.
    DOI Scopus51 WoS35 Europe PMC19
    2019 Chen, R., Chen, W. -C., Yan, L., Tian, S., Liu, B., Chen, X., . . . Zhang, W. (2019). Harnessing combinational phototherapy via post-synthetic PpIX conjugation on nanoscale metal-organic frameworks.. Journal of materials chemistry. B, 7(31), 4763-4770.
    DOI Scopus15 WoS10 Europe PMC4
    2019 Wan, Y., Lu, G., Zhang, J., Wang, Z., Li, X., Chen, R., . . . Lee, C. -S. (2019). A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy. ADVANCED FUNCTIONAL MATERIALS, 29(39), 10 pages.
    DOI Scopus113 WoS89
    2019 Cui, X., Zhang, J., Wan, Y., Fang, F., Chen, R., Shen, D., . . . Lee, C. S. (2019). Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells. ACS Applied Bio Materials, 2(9), 3854-3860.
    DOI Scopus48 WoS37 Europe PMC8
    2018 Zhang, J., Chen, J., Ren, J., Guo, W., Li, X., Chen, R., . . . Lee, C. -S. (2018). Biocompatible semiconducting polymer nanoparticles as robust photoacoustic and photothermal agents revealing the effects of chemical structure on high photothermal conversion efficiency.. Biomaterials, 181, 92-102.
    DOI Scopus74 WoS62 Europe PMC13
    2017 Wang, Z., Chen, R., Xiong, Y., Cepe, K., Schneider, J., Zboril, R., . . . Rogach, A. L. (2017). Chemical Sensing: Incorporating Copper Nanoclusters into Metal-Organic Frameworks: Confinement-Assisted Emission Enhancement and Application for Trinitrotoluene Detection (Part. Part. Syst. Charact. 6/2017). Particle and Particle Systems Characterization, 34(6).
    DOI Scopus18
    2017 Wang, Z., Chen, R., Xiong, Y., Cepe, K., Schneider, J., Zboril, R., . . . Rogach, A. L. (2017). Incorporating Copper Nanoclusters into Metal-Organic Frameworks: Confinement-Assisted Emission Enhancement and Application for Trinitrotoluene Detection. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 34(6), 6 pages.
    DOI Scopus30 WoS32
    2017 Chelora, J., Zhang, J., Chen, R., Chandran, H. T., & Lee, C. S. (2017). Highly stable red-emitting polymer dots for cellular imaging. Nanotechnology, 28(28), 7 pages.
    DOI Scopus7 WoS7 Europe PMC1
    2017 Chen, R., Zhang, J., Chelora, J., Xiong, Y., Kershaw, S. V., Li, K. F., . . . Lee, C. S. (2017). Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy. ACS Applied Materials and Interfaces, 9(7), 5699-5708.
    DOI Scopus155 WoS120 Europe PMC37
    2017 Zhang, J., Zhang, J., Li, W., Chen, R., Zhang, Z., Zhang, W., . . . Lee, C. -S. (2017). Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy <i>in Vitro</i> and <i>in Vivo</i>.. Theranostics, 7(12), 3007-3020.
    DOI Scopus84 WoS66 Europe PMC31
    2017 Zhang, J., Yang, C., Zhang, R., Chen, R., Zhang, Z., Zhang, W., . . . Lee, C. S. (2017). Biocompatible D–A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy. Advanced Functional Materials, 27(13), 10 pages.
    DOI Scopus212 WoS181 Europe PMC64
    2016 Wang, Z., Chen, B., Susha, A. S., Wang, W., Reckmeier, C. J., Chen, R., . . . Rogach, A. L. (2016). All-Copper Nanocluster Based Down-Conversion White Light-Emitting Devices. Advanced Science, 3(11), 7 pages.
    DOI Scopus94 WoS100 Europe PMC25
    2016 Zhang, J., Chen, W., Kalytchuk, S., Li, K. F., Chen, R., Adachi, C., . . . Lee, C. S. (2016). Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging. ACS Applied Materials and Interfaces, 8(18), 11355-11365.
    DOI Scopus63 WoS50 Europe PMC15
    2016 Zhang, J., Chen, W., Chen, R., Liu, X. K., Xiong, Y., Kershaw, S. V., . . . Lee, C. S. (2016). Organic nanostructures of thermally activated delayed fluorescent emitters with enhanced intersystem crossing as novel metal-free photosensitizers. Chemical Communications, 52(79), 11744-11747.
    DOI Scopus75 WoS59 Europe PMC15
    2015 Chen, R., Zhang, J., Wang, Y., Chen, X., Zapien, J. A., & Lee, C. S. (2015). Graphitic carbon nitride nanosheet@metal-organic framework core-shell nanoparticles for photo-chemo combination therapy. Nanoscale, 7(41), 17299-17305.
    DOI Scopus173 WoS151 Europe PMC44
    2015 Zhang, J., Chen, R., Zhu, Z., Adachi, C., Zhang, X., & Lee, C. S. (2015). Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging. ACS Applied Materials and Interfaces, 7(47), 26266-26274.
    DOI Scopus133 WoS40 Europe PMC39
    2014 Huang, H., Chen, R., Ma, J., Yan, L., Zhao, Y., Wang, Y., . . . Chen, X. (2014). Graphitic carbon nitride solid nanofilms for selective and recyclable sensing of Cu<sup>2+</sup> and Ag<sup>+</sup> in water and serum. Chemical Communications, 50(97), 15415-15418.
    DOI Scopus96 WoS91 Europe PMC17

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2023 Co-Supervisor Development of mRNA therapeutics Doctor of Philosophy Doctorate Full Time Mr Jitong Lyu
    2023 Co-Supervisor Development of platform technologies for mRNA therapeutics Doctor of Philosophy Doctorate Full Time Mr Zhenwei Lan
    2023 Co-Supervisor Comparative Analysis of mRNA Loading, Cargo Release, and Cellular Uptake Between Virus-Like Particles and Lipid Nanoparticles Doctor of Philosophy Doctorate Full Time Mr Xiaoyan Wang
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