Hon Yeung Chan

Research Interests

Fertility and Conception Men's Health Pregnancy and Birth Fertility Immunology Obstetrics & Reproductive Medicine Reproduction Reproductive Biology

Dr Hon Yeung Chan

ARC Grant-Funded Postdoctoral Research Fellow

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Hon Yeung (Dexter) Chan is a Postdoctoral Researcher in the Reproductive Immunology group at the Robinson Research Institute. His research aims to further the understanding and to define the significance of the male seminal fluid in the reproductive process, and the female response to signalling factors carried within the ejaculate. His research will help understand how both paternal and maternal factors contribute to normal reproductive processes and may ultimately, improve our understanding of the causes of infertility.

His current research interests include:

  1. the identification of the regulators of seminal fluid signalling that alter the female response to conception, such as signalling factors in the male ejaculate and receptors for these signalling moieties in the female reproductive tract 

     
  2. the mechanisms by which semen contributes to gene regulation in the uterus during the peri-implantation phase of pregnancy critical for female receptivity for successful embryo implantation 

Date Position Institution name
2020 - ongoing Postdoctoral Researcher University of Adelaide

Language Competency
Chinese (Cantonese) Can read, write, speak, understand spoken and peer review
Chinese (Mandarin) Can read, speak and understand spoken
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2015 - 2020 University of Adelaide Australia PhD in Medicine
2014 - 2014 University of Adelaide Australia Honours Degree of Bachelor of Health Sciences
2011 - 2013 University of Adelaide Australia Bachelor of Science (Biomedical Science)

Year Citation
2025 Chan, H. Y., Alesi, L. R., Dinh, D. T., Foyle, K. L., Hofstee, P., Hutchison, J. C., . . . Houston, B. J. (2025). Comparative reproductive biology, advances in reproductive health, and cultivating inclusion in the scientific community: highlights from the 2024 Annual Meeting of the Society for Reproductive Biology. Reproduction Fertility and Development, 37(17 Frontiers in Reproduction Science – Rising Stars at the Society for Reproductive Biology 2024), 13 pages.
DOI
2025 Foyle, K. L., Chan, H. Y., Tran, H. M., Breen, J., Schjenken, J. E., & Robertson, S. A. (2025). Seminal fluid expands the uterine gamma/delta T cell pool during early pregnancy in mice. Mucosal Immunology, 19(1), 1-16.
DOI
2025 Chan, H. Y., & Robertson, S. A. (2025). Seminal fluid effects on uterine receptivity to embryo implantation: transcriptomic strategies to define molecular mechanisms. Reproduction Fertility and Development, 37(6), RD24162-1-RD24162-15.
DOI Scopus4 WoS5 Europe PMC4
2024 Panir, K., Schjenken, J. E., Breen, J., Chan, H. Y., Greaves, E., Robertson, S. A., & Hull, M. L. (2024). RNA sequencing reveals novel molecular mechanisms of endometriosis lesion development in a mouse model. Disease Models & Mechanisms, 17(10), 16 pages.
DOI Scopus2 WoS2 Europe PMC2
2024 Hosking, S. L., Moldenhauer, L. M., Tran, H. M., Chan, H. Y., Groome, H. M., Lovell, E. A., . . . Care, A. S. (2024). Regulatory T cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice. JCI Insight, 10(2), e169836-1-e169836-21.
DOI Scopus17 WoS16 Europe PMC12
2024 Houston, B. J., Chan, H. Y., Clark, Z., Swegen, A., Wooldridge, A. L., & Green, E. S. (2024). Reproductive mechanisms, pathologies, and health inclusivity: insights from the 2023 Annual Meeting of the Society for Reproductive Biology.. Reprod Fertil Dev, 36(18), 14 pages.
DOI Scopus1 WoS1 Europe PMC1
2024 Green, E. S., Chan, H. Y., Frost, E., Griffiths, M., Hutchison, J., Martin, J. H., . . . Dunleavy, J. E. M. (2024). Recent advances in reproductive research in Australia and New Zealand: highlights from the Annual Meeting of the Society for Reproductive Biology, 2022. Reproduction, Fertility and Development, 36(4), 10 pages.
DOI Scopus2 WoS3 Europe PMC3
2024 Chin, P. Y., Chan, H. Y., Kieffer, T. E. C., Prins, J. R., Russell, D. L., Davies, M. J., & Robertson, S. A. (2024). Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice. Endocrinology, 165(7), bqae047-1-bqae047-15.
DOI Scopus2 WoS1 Europe PMC2
2023 Chan, H. Y., Tran, H. M., Breen, J., Schjenken, J. E., & Robertson, S. A. (2023). The endometrial transcriptome transition preceding receptivity to embryo implantation in mice. BMC Genomics, 24(1), 1-16.
DOI Scopus7 WoS7 Europe PMC8
2021 Schjenken, J. E., Sharkey, D. J., Green, E. S., Chan, H. Y., Matias, R. A., Moldenhauer, L. M., & Robertson, S. A. (2021). Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice. Communications Biology, 4(1), 1-14.
DOI Scopus49 WoS54 Europe PMC51
2021 Schjenken, J. E., Moldenhauer, L. M., Sharkey, D. J., Chan, H. Y., Chin, P. Y., Fullston, T., . . . Robertson, S. A. (2021). High fat diet alters male seminal plasma composition to impair female immune adaptation for pregnancy in mice. Endocrinology, 162(10), 1-20.
DOI Scopus35 WoS31 Europe PMC25
2021 Chan, H. Y., Moldenhauer, L. M., Groome, H. M., Schjenken, J. E., & Robertson, S. A. (2021). Toll-like receptor-4 null mutation causes fetal loss and fetal growth restriction associated with impaired maternal immune tolerance in mice.. Scientific reports, 11(1), 1-17.
DOI Scopus21 WoS24 Europe PMC15
2020 Schjenken, J. E., Moldenhauer, L. M., Zhang, B., Care, A. S., Groome, H. M., Chan, H. Y., . . . Robertson, S. A. (2020). MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice. Mucosal Immunology, 13(4), 609-625.
DOI Scopus42 WoS42 Europe PMC35
2020 McCarron, A., Cmielewski, P., Reyne, N., McIntyre, C., Finnie, J., Craig, F., . . . Donnelley, M. (2020). Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing. The American Journal of Pathology, 190(5), 977-993.
DOI Scopus37 WoS36 Europe PMC38
2017 Robertson, S., Zhang, B., Chan, H., Sharkey, D., Barry, S., Fullston, T., & Schjenken, J. (2017). MicroRNA regulation of immune events at conception. Molecular Reproduction and Development, 84(9), 914-925.
DOI Scopus25 WoS24 Europe PMC23
2016 Schjenken, J. E., Zhang, B., Chan, H. Y., Sharkey, D. J., Fullston, T., & Robertson, S. A. (2016). miRNA Regulation of Immune Tolerance in Early Pregnancy. American Journal of Reproductive Immunology, 75(3), 272-280.
DOI Scopus47 WoS44 Europe PMC42
2014 Chua, K., Pietsch, M., Zhang, X., Hautmann, S., Chan, H., Bruning, J., . . . Abell, A. (2014). Macrocyclic protease inhibitors with reduced peptide character. Angewandte Chemie International Edition, 53(30), 7828-7831.
DOI Scopus24 WoS23 Europe PMC15
- Schjenken, J. E., Moldenhauer, L., Sharkey, D., Chan, H. Y., Chin, L., Fullston, T., . . . Robertson, S. (n.d.). High fat diet alters male seminal plasma composition to impair female immune adaptation for pregnancy in mice.
DOI
- Chin, L., Kieffer, T., Chan, H. Y., Prins, J. R., Russell, D., Davies, M., & Robertson, S. (n.d.). Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice.
DOI

Year Citation
2020 Robertson, S. A., Schjenken, J. S., Moldenhauer, L. M., Zhang, B., Groome, H. M., Chan, H. Y., & Care, A. S. (2020). miR-155 Deficiency Impairs Pregnancy Tolerance and Predisposes to Inflammation-Induced Fetal Loss in Mice.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Vancouver, CANADA: SPRINGER HEIDELBERG.

Year Citation
- Chan, H. Y., Tran, H., Breen, J., Schjenken, J. E., & Robertson, S. (n.d.). <strong>The</strong> <strong>endometrial transcriptome transition preceding receptivity to embryo implantation in mice</strong>.
DOI

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Significance of impaired immune tolerance for infertility in men. Doctor of Philosophy Doctorate Full Time Ms Shreetha Ramasubramanian
2025 Co-Supervisor Significance of impaired immune tolerance for infertility in men. Doctor of Philosophy Doctorate Full Time Ms Shreetha Ramasubramanian
2024 Co-Supervisor Paternal MHC disparity and maternal immune adaptation to pregnancy. Doctor of Philosophy Doctorate Full Time Miss Le Phuong Uyen Pham
2024 Co-Supervisor Paternal MHC disparity and maternal immune adaptation to pregnancy. Doctor of Philosophy Doctorate Full Time Miss Le Phuong Uyen Pham
2023 Co-Supervisor Identity of seminal fluid antigens driving expansion of the female adaptive immune response after mating Doctor of Philosophy Doctorate Full Time Mr Ha Manh Tran
2023 Co-Supervisor Identity of seminal fluid antigens driving expansion of the female adaptive immune response after mating Doctor of Philosophy Doctorate Full Time Mr Ha Manh Tran

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