Ha Tran

Mr Ha Tran

Higher Degree by Research Candidate

PhD Students

School of Biomedicine

Faculty of Health and Medical Sciences

Ha Tran (he/him) is pursuing his PhD and holds a Bachelor of Science (Advanced) degree from the University of Adelaide, obtained in 2021. Born in Vietnam, he moved to Alice Springs (Mparntwe) in 2008 before heading to Adelaide in 2019 for his undergraduate studies in Immunology and Bioinformatics.

Ha's research is centred around the study of mammalian reproduction and development, with a focus on the immune regulation of fertility and pregnancy by male seminal fluid factors. He leverages cutting-edge technologies such as flow cytometry, single-cell sequencing, and machine learning to advance the understanding of T cell activation by seminal fluid proteins, which will be vital for enhancing breeding efficiency and reducing wastage in endangered species conservation and agriculture.

In his spare time, he enjoys making elaborate meals with produce grown in his suburban backyard. As an ex-Territorian, he thoroughly enjoys camping, 4WD, and anything related to the Outback.

PhD Research

Role of seminal fluid histocompatibility antigens in T cell priming after mating in mice.

At conception, seminal fluid introduces factors into the female reproductive tract that help her immune system accept the genetically different fetus. Key proteins in this fluid, known as major and minor histocompatibility antigens (MHC and MiHC), may affect immune tolerance and pregnancy by triggering maternal T cell responses. Our study explores how these seminal fluid antigens initiate a T cell response that supports successful pregnancy.

Other Projects

1. Role of paternal beta-defensin 22 in promoting maternal immune tolerance and receptivity to implantation in mice.

During mating, molecules in seminal plasma and sperm work with the female reproductive system to trigger an immune reaction that helps her body become ready for pregnancy. This research examines the role of DEFB22, a protein in mice that corresponds to human DEFB126, in how seminal fluid influences fertility and the ability to produce offspring.

 

  • Journals
    Year Citation
    2023 Chan, H. Y., Tran, H. M., Breen, J., Schjenken, J. E., & Robertson, S. A. (2023). The endometrial transcriptome transition preceding receptivity to embryo implantation in mice. BMC Genomics, 24(1), 1-16.
    DOI Europe PMC1

  • Conference Items
    Year Citation
    2023 Tran, H., Chan, H. Y., Adelson, D. L., & Robertson, S. A. (2023). Seminal fluid histocompatibility antigens contribute to T cell priming after mating in mice. Poster session presented at the meeting of Society of Reproductive Biology. Brisbane.
    2022 Chan, H. Y., Tran, H. M., Breen, J., Schjenken, J., & Robertson, S. (2022). The endometrial transcriptome transition preceding receptivity to embryo implantation in mice. Poster session presented at the meeting of Society of Reproduction. Christchurch, New Zealand.
    2022 Chan, H. Y., Tran, H. M., Breen, J., Schjenken, J., & Robertson, S. (2022). The endometrial transcriptome transition preceding receptivity to embryo implantation in mice. Poster session presented at the meeting of Society of Reproduction. Christchurch, New Zealand.

  • Software
    Year Citation
    2023 Tran, H. (2023). The endometrial transcriptome transition preceding receptivity to embryo implantation in mice [Computer Software]. https://github.com/tranmanhha135/Mouse_endometrial_transcriptome_2023.

  • Memberships
    Date Role Membership Country
    2024 - ongoing Member Society for the Study of Reproduction (SSR) United States
    2022 - ongoing Member The Society of Reproductive Biology (SRB) Australia
    2022 - ongoing Member The Australian Bioinformatics and Computational Biology Society (ABACBS) Australia
    2022 - ongoing Member Australian and New Zealand Society for Immunology (ASI) Australia
    2021 - ongoing Member International Society for Computational Biology (ISCB) United States

  • Presentation
    Date Topic Presented at Institution Country
    2023 - ongoing Seminal fluid histocompatibility antigens contribute to T cell priming after mating in mice - The Society of Reproductive Biology Australia
  • Position: PhD Students
  • Phone: 00474226079
  • Email: ha.m.tran@adelaide.edu.au
  • Campus: West End Health Precinct
  • Building: AHMS - Adelaide Health and Medical Sciences, floor Sixth Floor
  • Org Unit: Adelaide Medical School
Connect With Me
External Profiles