Mohammed Alsharifi

Research Interests

Immunology Infectious Diseases Medical Microbiology Medical Virology Vaccinology

Dr Mohammed Alsharifi

Senior Lecturer

School of Biological Sciences

College of Science

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Alsharifi studied Biomedical Science at Monash University. After graduating with First Class Honours, he moved to the Australian National University to take up a PhD scholarship at The John Curtin School of Medical Research (JCSMR). During his PhD, he investigated with Prof Arno Müllbacher, Prof Robert Blanden, and Dr Mario Lobigs the immunobiology of an alphavirus infection. Based on his PhD research, he published many papers describing some important concepts related to type-I interferon responses following an acute primary viral infection and the increased risk to a more sever secondary viral and/or bacterial infection. Following the completion of his PhD, he remained at the JCSMR as postdoctoral fellow to investigated with Prof Müllbacher the use of γ-irradiated influenza preparations as a universal flu vaccine candidate, funded by the NHMRC. This work resulted in multiple patents and the establishment of a biotech company (Gamma Vaccine Pty Ltd). In 2008, he was awarded the Hanson Fellowship to established an independent research group and to continue his research into the universal Flu vaccine and also the possibility of producing other vaccines using similar technique. In 2010, he relocated his group to the School of Biological Science/ The University of Adelaide and in collaboration with James Paton attracted funding from ARC and NHMRC to develop a single vaccine for influenza and pneumonia with “Gamma Vaccines Pty Ltd” as the Commercial Partner Organisation. This work resulted in patentable IP surrounding a novel pneumococcal whole cell vaccine and the formation of "GPN Vaccines Pty Ltd". In addition, he had been invited by the International Atomic Energy Agency (IAEA) as a technical expert to take part in IAEA’s coordinated research program to investigate the use of gamma-ray inactivation of pathogens for vaccine purposes.Many of Dr Alsharifi's work has been published in high ranked peer-reviewed scientific journals and his flu vaccine research has been featured in the Catalyst program on ABC (http://www.abc.net.au/catalyst/stories/2613604.htm), and in many newspaper articles such as (http://www.news.com.au/adelaidenow/story/0,,25625291-5018662,00.html) and (http://www.news.com.au/adelaidenow/story/0,22606,25406694-5006301,00.html).

Date Position Institution name
2016 - ongoing Senior Lecturer University of Adelaide
2013 - 2015 Visiting Professor Management and Science University
2012 - 2016 Lecturer University of Adelaide
2010 - 2012 Research Fellow University of Adelaide

Language Competency
Arabic -
English -

Date Institution name Country Title
2005 Australian National University Australia Ph.D
2004 Australian National University Australia Certificate (with merit) in graduate teaching
2001 Monash University Australia Bachelor of Biomedical Science (Honours, Class I)

Date Title Institution Country
2008 - 2010 RRC Research Fellow SA Health Australia
2005 - 2007 Postdoctoral fellow Australian National University Australia

Year Citation
2025 Gates, C. J., Brazel, E. B., Kennedy, E. V., Brown, J. S., Ercoli, G., Davies, J., . . . Alsharifi, M. (2025). A gamma-irradiated pneumococcal vaccine elicits superior immunogenicity in comparison to heat or chemically inactivated whole-cell vaccines.. Vaccine, 54, 126982-1-126982-10.
DOI
2025 Hall, J., Psaltis, A., Vreugde, S., Feizi, S., Chuah, Y., Alsharifi, M., & Ramezanpour, M. (2025). Effects of influenza A infection on liberation of bacteria from biofilms and inflammatory response in an in vitro model of chronic rhinosinusitis.. Microbiology (Reading), 171(8), 9 pages.
DOI
2024 Brazel, E. B., Alsharifi, M., Giorgio, L., Hirst, T., & Paton, J. (2024). Whole-cell pneumococcal vaccines: a future-proof approach to overcoming pneumococcal serotype replacement. Vaccine Insights, 3(1), 17-22.
DOI
2023 Abbott, C. A., Freimayer, E. L., Tyllis, T. S., Norton, T. S., Alsharifi, M., H S Heng, A., . . . Comerford, I. (2023). Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection. Mucosal Immunology, 16(5), 606-623.
DOI Scopus3 WoS3 Europe PMC5
2022 David, S. C., Brazel, E. B., Singleton, E. V., Minhas, V., Laan, Z., Scougall, C., . . . Alsharifi, M. (2022). A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies. mBio, 13(5), 02367-22-1-02367-22-21.
DOI Scopus5 WoS6 Europe PMC6
2021 Tyllis, T. S., Fenix, K. A., Norton, T. S., Kara, E. E., McKenzie, D. R., David, S. C., . . . Comerford, I. (2021). CXCR5⁺CD8⁺ T cells shape antibody responses In Vivo following protein immunisation and peripheral viral infection. Frontiers in Immunology, 12, 626199-1-626199-14.
DOI Scopus15 WoS15 Europe PMC13
2021 Singleton, E., Gates, C. J., David, S. C., Hirst, T. R., Davies, J. B., & Alsharifi, M. (2021). Enhanced Immunogenicity of a Whole-Inactivated Influenza A Virus Vaccine Using Optimised Irradiation Conditions. Frontiers in Immunology, 12, 1-12.
DOI Scopus6 WoS6 Europe PMC6
2020 Rabiei, M., Cahyono, M. I., Doan, P. T. K., Pandarangga, P., Tarigan, S., Indriani, R., . . . Hemmatzadeh, F. (2020). Genome Sequences of Newly Emerged Newcastle Disease Virus Strains Isolated from Disease Outbreaks in Indonesia.. Microbiol Resour Announc, 9(23), 4 pages.
DOI Scopus4 WoS3 Europe PMC3
2020 Doan, P. T. K., Cahyono, M. I., Rabiei, M., Pandarangga, P., McAllister, M. M., Low, W. Y., . . . Hemmatzadeh, F. (2020). Genome Sequences of Newcastle Disease Virus Strains from Two Outbreaks in Indonesia.. Microbiology resource announcements, 9(23), 3 pages.
DOI Scopus8 WoS8 Europe PMC7
2020 Singleton, E. V., David, S. C., Davies, J. B., Hirst, T. R., Paton, J. C., Beard, M. R., . . . Alsharifi, M. (2020). Sterility of gamma-irradiated pathogens: a new mathematical formula to calculate sterilizing doses. Journal of Radiation Research, 61(6), 886-894.
DOI Scopus17 WoS16 Europe PMC12
2020 Rabiei, M., Cahyono, M. I., Doan, P. T. K., Pandarangga, P., Tarigan, S., Indriani, R., . . . Hemmatzadeh, F. (2020). Correction for Rabiei et al., "Genome Sequences of Newly Emerged Newcastle Disease Virus Strains Isolated from Disease Outbreaks in Indonesia".. Microbiol Resour Announc, 9(38), 2 pages.
DOI
2019 David, S. C., Laan, Z., Minhas, V., Chen, A. Y., Davies, J., Hirst, T. R., . . . Paton, J. C. (2019). Enhanced safety and immunogenicity of a pneumococcal surface antigen A mutant whole-cell inactivated pneumococcal vaccine. Immunology and Cell Biology, 97(8), 1-14.
DOI Scopus9 WoS10 Europe PMC9
2019 David, S. C., Norton, T., Tyllis, T., Wilson, J. J., Singleton, E. V., Laan, Z., . . . Alsharifi, M. (2019). Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity. Nature Microbiology, 4(8), 1316-1327.
DOI Scopus24 WoS23 Europe PMC23
2018 Kara, E. E., Bastow, C. R., McKenzie, D. R., Whyte, C. E., Fenix, K. A., Babb, R., . . . McColl, S. R. (2018). Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), 801-813.
DOI Scopus21 WoS21 Europe PMC23
2018 Shahrudin, S., Chen, C., David, S., Singleton, E., Davies, J., Kirkwood, C., . . . Alsharifi, M. (2018). Gamma-irradiated rotavirus: a possible whole virus inactivated vaccine. PLoS ONE, 13(6), e0198182-1-e0198182-15.
DOI Scopus17 WoS15 Europe PMC14
2017 Babb, R., Chen, A., Ogunniyi, A., Hirst, T., Kara, E., McColl, S., . . . Paton, J. (2017). Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine. Clinical Science, 131(2), 169-180.
DOI Scopus20 WoS18 Europe PMC15
2017 Al-Shujairi, W., Clarke, J., Davies, L., Alsharifi, M., Pitson, S., & Carr, J. (2017). Intracranial injection of dengue virus induces interferon stimulated genes and CD8⁺ T cell infiltration by sphingosine kinase 1 independent pathways. PLoS One, 12(1), 0169814-1-0169814-12.
DOI Scopus11 WoS11 Europe PMC9
2017 David, S. C., Lau, J., Singleton, E. V., Babb, R., Davies, J., Hirst, T. R., . . . Alsharifi, M. (2017). The effect of gamma-irradiation conditions on the immunogenicity of whole-inactivated Influenza A virus vaccine. Vaccine, 35(7), 1071-1079.
DOI Scopus33 WoS31 Europe PMC26
2017 Alsharifi, M., & David, S. C. (2017). Virus inactivation using a high dose of gamma-irradiation: a possible approach for safer vaccines against highly infectious agents. Journal of Vaccines & Vaccination, 8(3), 1000360-1-1000360-2.
DOI
2016 Stevens, N., Hatjopolous, A., Fraser, C., Alsharifi, M., Diener, K., & Hayball, J. (2016). Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection. Scientific Reports, 6(1), 1-13.
DOI Scopus9 WoS9 Europe PMC7
2016 Chan, J., Babb, R., David, S., Mccoll, S., & Alsharifi, M. (2016). Vaccine-Induced Antibody Responses Prevent the Induction of Interferon Type I Responses Upon a Homotypic Live Virus Challenge. Scandinavian Journal of Immunology, 83(3), 165-173.
DOI Scopus4 WoS3 Europe PMC3
2016 Babb, R., Chen, A., Hirst, T., Kara, E., McColl, S., Ogunniyi, A., . . . Alsharifi, M. (2016). Intranasal vaccination with γ -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses. Clinical Science, 130(9), 697-710.
DOI Scopus45 WoS38 Europe PMC36
2014 Ebrahimi, M., Aghagolzadeh, P., Shamabadi, N., Tahmasebi, A., Alsharifi, M., Adelson, D., . . . Ebrahimie, E. (2014). Understanding the undelaying mechanism of HASubtyping in the level of physic-chemal characteristics of protein. PLoS One, 9(5), e96984-1-e96984-14.
DOI Scopus27 WoS22 Europe PMC20
2014 Babb, R., Chan, J., Khairat, J., Furuya, Y., & Alsharifi, M. (2014). Gamma-irradiated influenza A virus provides adjuvant activity to a co-administered poorly immunogenic SFV vaccine in mice. Frontiers in Immunology, 5(Jun), 267-1-267-7.
DOI Scopus12 WoS10 Europe PMC9
2013 Alsharifi, M., Koskinen, A., Wijesundara, D., Bettadapura, J., & Mullbacher, A. (2013). MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One, 8(6), e68458-1-e68458-8.
DOI Scopus3 WoS3 Europe PMC3
2013 Stevens, N., Fraser, C., Alsharifi, M., Brown, M., Diener, K., & Hayball, J. (2013). An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant. PLoS One, 8(7), 1-10.
DOI Scopus11 WoS9 Europe PMC10
2011 Furuya, Y., Chan, J., Wan, E., Koskinen, A., Diener, K., Hayball, J., . . . Alsharifi, M. (2011). Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. PLoS One, 6(10), e25765-1-e25765-12.
DOI Scopus18 WoS16 Europe PMC15
2010 Wijesundara, D., Kumar, S., Alsharifi, M., Mullbacher, A., & Regner, M. (2010). Antigen-specific activation thresholds of CD8⁺ T cells are independent of IFN-I-mediated partial lymphocyte activation. International Immunology, 22(9), 757-767.
DOI Scopus3 WoS3 Europe PMC3
2010 Furuya, Y., Chan, J., Regner, M., Lobigs, M., Koskinen, A., Kok, T., . . . Alsharifi, M. (2010). Cytoxic T cells are the predominant players providing cross-protective immunity induced by y-irradiated influenza A viruses. Journal of Virology, 84(9), 4212-4221.
DOI Scopus73 WoS71 Europe PMC63
2010 Furuya, Y., Regner, M., Lobigs, M., Koskinen, A., Mullbacher, A., & Alsharifi, M. (2010). Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations. Journal of General Virology, 91(6), 1450-1460.
DOI Scopus67 WoS61 Europe PMC51
2010 Alsharifi, M., & Mullbacher, A. (2010). The γ-irradiated influenza vaccine and the prospect of producing safe vaccines in general. Immunology and Cell Biology, 88(2), 103-104.
DOI Scopus49 WoS47 Europe PMC43
2009 Lobigs, M., Larena, M., Alsharifi, M., Lee, E., & Pavy, M. (2009). Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. Journal of Virology, 83(6), 2436-2445.
DOI Scopus54 WoS47 Europe PMC43
2009 Alsharifi, M., Furuya, Y., Bowden, T., Lobigs, M., Koskinen, A., Regner, M., . . . Mullbacher, A. (2009). Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections. PLoS One, 4(4), 1-6.
DOI Scopus57 WoS52 Europe PMC49
2008 Alsharifi, M., Lobigs, M., Bettadapura, J., Koskinen, A., & Mullbacher, A. (2008). Restricted Semliki Forest virus replication in communication perforin and Fas-ligand double-deficient mice. Journal of General Virology, 89(8), 1942-1944.
DOI Scopus3 WoS3 Europe PMC3
2008 Alsharifi, M., Muellbacher, A., & Regner, M. (2008). Interferon type I responses in primary and secondary infections. Immunology and Cell Biology, 86(3), 239-245.
DOI Scopus55 WoS53 Europe PMC53
2007 Budd, A., Alleva, L., Alsharifi, M., Koskinen, A., Smythe, V., Müllbacher, A., . . . Clark, I. (2007). Increased survival after gemfibrozil treatment of severe mouse influenza. Antimicrobial Agents and Chemotherapy, 51(8), 2965-2968.
DOI Scopus91 WoS89 Europe PMC78
2006 Alsharifi, M., Regner, M., Blanden, R., Lobigs, M., Lee, E., Koskinen, A., & Müllbacher, A. (2006). Exhaustion of type I interferon response following an acute viral infection. Journal of Immunology, 177(5), 3235-3241.
DOI Scopus30 WoS28 Europe PMC24
2006 Alsharifi, M., Lobigs, M., Simon, M. M., Kersten, A., Müller, K., Koskinen, A., . . . Müllbacher, A. (2006). NK cell-mediated immunopathology during an acute viral infection of the CNS. European Journal of Immunology, 36(4), 887-896.
DOI Scopus32 WoS32 Europe PMC30
2006 Müllbacher, A., Lobigs, M., Alsharifi, M., & Regner, M. (2006). Cytotoxic T-cell immunity as a target for influenza vaccines. Lancet Infectious Diseases, 6(5), 255-256.
DOI Scopus15 WoS14 Europe PMC15
2005 Rosen, D. B., Bettadapura, J., Alsharifi, M., Mathew, P. A., Warren, H. S., & Lanier, L. L. (2005). Cutting edge: Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. Journal of Immunology, 175(12), 7796-7799.
DOI Scopus234 WoS228 Europe PMC214
2005 Alsharifi, M., Lobigs, M., Regner, M., Lee, E., Koskinen, A., & Müllbacher, A. (2005). Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection. Journal of Immunology, 175(7), 4635-4640.
DOI Scopus41 WoS38 Europe PMC40

Year Citation
2016 David, S., Paton, J., McColl, S., & Alsharifi, M. (2016). Gamma-irradiated influenza A virus vaccine: irradiation conditions & vaccine efficacy. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 1236). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2007 Alsharifi, M., Regner, M., Blanden, R., Lobigs, M., Lee, E., Koskinen, A., & Muellbacher, A. (2007). Interferon type-I responses in primary and secondary viral infections. In CYTOKINE Vol. 39 (pp. 1). San Francisco, CA: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD.
DOI WoS1
2005 Alsharifi, M., Lobigs, M., Regner, M., Koskinen, E. L. A., & Müllbacher, A. (2005). Exhaustion of type-I interferon response following an acute viral infection. In TISSUE ANTIGENS Vol. 66 (pp. 345-346). Melbourne, AUSTRALIA: BLACKWELL PUBLISHING.

Year Citation
2019 David, S. C., Laan, Z., Chen, A., Hirst, T., Paton, J., & Alsharifi, M. (2019). A novel co-vaccination strategy to provide serotype-independent protection against pneumococcal infections. Poster session presented at the meeting of 14th European Meeting on the Molecular Biology of the Pneumococcus (Europneumo). Greifswald, Germany.
2019 David, S. C., Singleton, E., Laan, Z., Chen, A., Hirst, T., Comerford, I., . . . Alsharifi, M. (2019). A novel co-vaccination strategy for cross-reactive immunity against influenza A & pneumococcal infections. Poster session presented at the meeting of Australian & New Zealand Society for Immunology (ASI) Meeting. Adelaide, Australia.
2018 David, S. C., Babb, R., McColl, S., Paton, J., & Alsharifi, M. (2018). Bi-directional adjuvant activity of co-administered pneumococcal and influenza A vaccines. Poster session presented at the meeting of International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11). Melbourne, Australia.
2017 David, S. C., Paton, J., McColl, S., & Alsharifi, M. (2017). Enhancement of influenza-specific immunity following intranasal co-administration of whole inactivated Influenza and pneumococcal vaccines. Poster session presented at the meeting of Australian Virology Society (AVS).
2016 David, S. C., Lau, J., Singleton, E., Paton, J., McColl, S., & Alsharifi, M. (2016). THE EFFECT OF GAMMA-IRRADIATION CONDITIONS ON THE IMMUNOGENICITY OF WHOLE-INACTIVATED INFLUENZA A VIRUS VACCINE. Poster session presented at the meeting of Adelaide Immunology Retreat (AIR-12) Meeting. Adelaide, Australia.
2016 Fenix, K., Kara, E., Bastow, C., Gregor, C., McKenzie, D., Norton, T., . . . McColl, S. (2016). CCR2 Is critical for memory CD8 T cell generation following influenza A virus infection. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL.

Year Citation
2021 David, S., Alsharifi, M., Brazel, E., Hirst, T., & Paton, J. (2021). US20210361758A1, Streptococcal vaccines and methods for use. US.
2021 Brazel, E., Alsharifi, M., David, S., Hirst, T., & Paton, J. (2021). US20210361757A1, Streptococcal vaccine formulations and uses thereof. US.
2016 Alsharifi, M., Babb, R., Chen, A. Y., David, S. C., Hirst, T. R., Ogunniyi, A. D., & Paton, J. C. (2016). 050231, Streptococcal Vaccine. Australia.
2015 Alsharifi, M., Babb, R., Chen, A. Y., Hirst, T. R., Ogunniyi, A. D., & Paton, J. C. (2015). 2015901098, Streptococcal Vaccine. Australia.

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Evaluation of a broad-spectrum otitis media vaccine Master of Philosophy Master Full Time Mr Jack William Robert Basso
2025 Principal Supervisor Cross-protective influenza vaccine Doctor of Philosophy Doctorate Full Time Mr En Rui Wong
2024 Principal Supervisor A combination vaccine targeting Newcastle Disease Virus and Influenza A virus for poultry Doctor of Philosophy Doctorate Full Time Ms Yimin Chuah
2024 Co-Supervisor Development of a novel whole-inactivated Streptococcal vaccine Doctor of Philosophy Doctorate Full Time Ms Rachel Chin
2023 Co-Supervisor Developing a novel cross-protective, inactivated vaccine against non-typeable Haemophilus influenzae Doctor of Philosophy Doctorate Full Time Ms Carla Ruth Gallasch

Date Role Research Topic Program Degree Type Student Load Student Name
2023 - 2025 Principal Supervisor Immune Responses Induced by Highly Purified Inactivated Influenza Vaccines Doctor of Philosophy Doctorate Full Time Miss Mariana Couto Moniz
2023 - 2025 Principal Supervisor Assessing the Oncolytic Activity of Inactivated Newcastle Disease Virus Master of Philosophy Master Full Time Miss Amal Hazem Mohammed Nour Afify Moh Mostafa
2020 - 2024 Principal Supervisor Enhancing the Stability and Immunogenicity of a Whole-Cell Pneumococcal Vaccine Doctor of Philosophy Doctorate Full Time Ms Chloe Gates
2018 - 2020 Principal Supervisor Humoral responses induced by an enzymatically active, whole-cell killed pneumococcal vaccine Master of Philosophy Master Full Time Miss Zoe Laan
2017 - 2020 Principal Supervisor Sterility and Immunogenicity of Gamma Irradiated Respiratory Viruses Doctor of Philosophy Doctorate Full Time Miss Eve Victoria Singleton
2016 - 2018 Principal Supervisor Enhancement of pathogen-specific immunity following co-administration of whole inactivated respiratory vaccines Doctor of Philosophy Doctorate Full Time Dr Shannon Christa David
2014 - 2014 Co-Supervisor Chikungunya Virus: Evidence for Global Policy, Practice and Research in Disease Management, Surveillance and Mosquito Control Doctor of Philosophy Doctorate Full Time Miss Zhili Chen
2013 - 2017 Co-Supervisor The role of chemokine receptors CCR2 and CXCR5 in CD8 positive T cell biology Doctor of Philosophy Doctorate Full Time Dr Kevin Aaron Fenix
2012 - 2017 Principal Supervisor Development of a Novel Co-vaccination Approach for Pneumococcal and Influenza Infections Doctor of Philosophy Doctorate Full Time Miss Rachelle Babb
2012 - 2013 Principal Supervisor Pre-existing strain specific neutralising antibodies abrogates the induction of interferon type I and cytotoxic T cell responses to subsequent homotypic influenza A virus challenge Master of Philosophy Master Full Time Miss Jennifer Chan

Date Role Editorial Board Name Institution Country
2012 - ongoing Editor PLoS One - -

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