Dr Mohammed Alsharifi

Senior Lecturer

School of Biological Sciences

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Alsharifi studied Biomedical Science at Monash University. After graduating with First Class Honours, he moved to the Australian National University to take up a PhD scholarship at The John Curtin School of Medical Research (JCSMR). During his PhD, he investigated with Prof Arno Müllbacher, Prof Robert Blanden, and Dr Mario Lobigs the immunobiology of an alphavirus infection. Based on his PhD research, he published many papers describing some important concepts related to type-I interferon responses following an acute primary viral infection and the increased risk to a more sever secondary viral and/or bacterial infection. Following the completion of his PhD, he remained at the JCSMR as postdoctoral fellow to investigated with Prof Müllbacher the use of γ-irradiated influenza preparations as a universal flu vaccine candidate, funded by the NHMRC. This work resulted in multiple patents and the establishment of a biotech company (Gamma Vaccine Pty Ltd). In 2008, he was awarded the Hanson Fellowship to established an independent research group and to continue his research into the universal Flu vaccine and also the possibility of producing other vaccines using similar technique. In 2010, he relocated his group to the School of Biological Science/ The University of Adelaide and in collaboration with James Paton attracted funding from ARC and NHMRC to develop a single vaccine for influenza and pneumonia with “Gamma Vaccines Pty Ltd” as the Commercial Partner Organisation. This work resulted in patentable IP surrounding a novel pneumococcal whole cell vaccine and the formation of "GPN Vaccines Pty Ltd". In addition, he had been invited by the International Atomic Energy Agency (IAEA) as a technical expert to take part in IAEA’s coordinated research program to investigate the use of gamma-ray inactivation of pathogens for vaccine purposes.
Many of Dr Alsharifi's work has been published in high ranked peer-reviewed scientific journals and his flu vaccine research has been featured in the Catalyst program on ABC (http://www.abc.net.au/catalyst/stories/2613604.htm), and in many newspaper articles such as (http://www.news.com.au/adelaidenow/story/0,,25625291-5018662,00.html) and (http://www.news.com.au/adelaidenow/story/0,22606,25406694-5006301,00.html).

Career
Publications
Supervision
Professional Activities
Contact

Appointments

Date	Position	Institution name
2016 - ongoing	Senior Lecturer	University of Adelaide
2013 - 2015	Visiting Professor	Management and Science University
2012 - 2016	Lecturer	University of Adelaide
2010 - 2012	Research Fellow	University of Adelaide

Language Competencies

Language Competency

Arabic -

English -

Language	Competency
Arabic	-
English	-

Education

Date	Institution name	Country	Title
2005	Australian National University	Australia	Ph.D
2004	Australian National University	Australia	Certificate (with merit) in graduate teaching
2001	Monash University	Australia	Bachelor of Biomedical Science (Honours, Class I)

Postgraduate Training

Date Title Institution Country

2008 - 2010 RRC Research Fellow SA Health Australia

2005 - 2007 Postdoctoral fellow Australian National University Australia
Research Interests

Immunology Infectious Diseases Medical Microbiology Medical Virology Vaccinology

Date	Title	Institution	Country
2008 - 2010	RRC Research Fellow	SA Health	Australia
2005 - 2007	Postdoctoral fellow	Australian National University	Australia

Journals

Year	Citation
2024	Brazel, E., Alsharifi, M., & Giorgio, L. (2024). Whole-cell pneumococcal vaccines: a future-proof approach to overcoming pneumococcal serotype replacement. Vaccine Insights, 03(01), 17-22. DOI
2023	Abbott, C. A., Freimayer, E. L., Tyllis, T. S., Norton, T. S., Alsharifi, M., H S Heng, A., . . . Comerford, I. (2023). Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection. Mucosal Immunology, 16(5), 606-623. DOI Scopus3 Europe PMC3
2022	David, S. C., Brazel, E. B., Singleton, E. V., Minhas, V., Laan, Z., Scougall, C., . . . Alsharifi, M. (2022). A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies. mBio, 13(5), 02367-22-1-02367-22-21. DOI Scopus1
2021	Tyllis, T. S., Fenix, K. A., Norton, T. S., Kara, E. E., McKenzie, D. R., David, S. C., . . . Comerford, I. (2021). CXCR5⁺CD8⁺ T cells shape antibody responses In Vivo following protein immunisation and peripheral viral infection. Frontiers in Immunology, 12, 626199-1-626199-14. DOI Scopus12 WoS8 Europe PMC9
2021	Singleton, E., Gates, C. J., David, S. C., Hirst, T. R., Davies, J. B., & Alsharifi, M. (2021). Enhanced Immunogenicity of a Whole-Inactivated Influenza A Virus Vaccine Using Optimised Irradiation Conditions. Frontiers in Immunology, 12, 1-12. DOI Scopus4 WoS3 Europe PMC4
2020	Rabiei, M., Cahyono, M. I., Doan, P. T. K., Pandarangga, P., Tarigan, S., Indriani, R., . . . Hemmatzadeh, F. (2020). Genome Sequences of Newly Emerged Newcastle Disease Virus Strains Isolated from Disease Outbreaks in Indonesia.. Microbiol Resour Announc, 9(23), 4 pages. DOI Scopus4 WoS2 Europe PMC2
2020	Doan, P. T. K., Cahyono, M. I., Rabiei, M., Pandarangga, P., McAllister, M. M., Low, W. Y., . . . Hemmatzadeh, F. (2020). Genome Sequences of Newcastle Disease Virus Strains from Two Outbreaks in Indonesia.. Microbiology resource announcements, 9(23), 3 pages. DOI Scopus8 WoS5 Europe PMC6
2020	Singleton, E. V., David, S. C., Davies, J. B., Hirst, T. R., Paton, J. C., Beard, M. R., . . . Alsharifi, M. (2020). Sterility of gamma-irradiated pathogens: a new mathematical formula to calculate sterilizing doses. Journal of Radiation Research, 61(6), 886-894. DOI Scopus14 WoS8 Europe PMC9
2020	Rabiei, M., Cahyono, M. I., Doan, P. T. K., Pandarangga, P., Tarigan, S., Indriani, R., . . . Hemmatzadeh, F. (2020). Correction for Rabiei et al., "Genome Sequences of Newly Emerged Newcastle Disease Virus Strains Isolated from Disease Outbreaks in Indonesia".. Microbiol Resour Announc, 9(38), 2 pages. DOI
2019	David, S. C., Laan, Z., Minhas, V., Chen, A. Y., Davies, J., Hirst, T. R., . . . Paton, J. C. (2019). Enhanced safety and immunogenicity of a pneumococcal surface antigen A mutant whole-cell inactivated pneumococcal vaccine. Immunology and Cell Biology, 97(8), 1-14. DOI Scopus7 WoS7 Europe PMC6
2019	David, S. C., Norton, T., Tyllis, T., Wilson, J. J., Singleton, E. V., Laan, Z., . . . Alsharifi, M. (2019). Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity. Nature Microbiology, 4(8), 1316-1327. DOI Scopus18 WoS14 Europe PMC13
2018	Kara, E. E., Bastow, C. R., McKenzie, D. R., Whyte, C. E., Fenix, K. A., Babb, R., . . . McColl, S. R. (2018). Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), 801-813. DOI Scopus20 WoS16 Europe PMC12
2018	Shahrudin, S., Chen, C., David, S., Singleton, E., Davies, J., Kirkwood, C., . . . Alsharifi, M. (2018). Gamma-irradiated rotavirus: a possible whole virus inactivated vaccine. PLoS ONE, 13(6), e0198182-1-e0198182-15. DOI Scopus15 WoS13 Europe PMC12
2017	Babb, R., Chen, A., Ogunniyi, A., Hirst, T., Kara, E., McColl, S., . . . Paton, J. (2017). Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine. Clinical Science, 131(2), 169-180. DOI Scopus19 WoS15 Europe PMC9
2017	Al-Shujairi, W., Clarke, J., Davies, L., Alsharifi, M., Pitson, S., & Carr, J. (2017). Intracranial injection of dengue virus induces interferon stimulated genes and CD8⁺ T cell infiltration by sphingosine kinase 1 independent pathways. PLoS One, 12(1), 0169814-1-0169814-12. DOI Scopus11 WoS10 Europe PMC8
2017	David, S. C., Lau, J., Singleton, E. V., Babb, R., Davies, J., Hirst, T. R., . . . Alsharifi, M. (2017). The effect of gamma-irradiation conditions on the immunogenicity of whole-inactivated Influenza A virus vaccine. Vaccine, 35(7), 1071-1079. DOI Scopus29 WoS27 Europe PMC19
2017	Alsharifi, M., & David, S. C. (2017). Virus inactivation using a high dose of gamma-irradiation: a possible approach for safer vaccines against highly infectious agents. Journal of Vaccines & Vaccination, 8(3), 1000360-1-1000360-2. DOI
2016	Stevens, N., Hatjopolous, A., Fraser, C., Alsharifi, M., Diener, K., & Hayball, J. (2016). Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection. Scientific Reports, 6(1), 1-13. DOI Scopus8 WoS8 Europe PMC7
2016	Chan, J., Babb, R., David, S., Mccoll, S., & Alsharifi, M. (2016). Vaccine-Induced Antibody Responses Prevent the Induction of Interferon Type I Responses Upon a Homotypic Live Virus Challenge. Scandinavian Journal of Immunology, 83(3), 165-173. DOI Scopus4 WoS3 Europe PMC3
2016	Babb, R., Chen, A., Hirst, T., Kara, E., McColl, S., Ogunniyi, A., . . . Alsharifi, M. (2016). Intranasal vaccination with γ -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses. Clinical Science, 130(9), 697-710. DOI Scopus42 WoS34 Europe PMC29
2014	Ebrahimi, M., Aghagolzadeh, P., Shamabadi, N., Tahmasebi, A., Alsharifi, M., Adelson, D., . . . Ebrahimie, E. (2014). Understanding the undelaying mechanism of HASubtyping in the level of physic-chemal characteristics of protein. PLoS One, 9(5), e96984-1-e96984-14. DOI Scopus26 WoS18 Europe PMC15
2014	Babb, R., Chan, J., Khairat, J., Furuya, Y., & Alsharifi, M. (2014). Gamma-irradiated influenza A virus provides adjuvant activity to a co-administered poorly immunogenic SFV vaccine in mice. Frontiers in Immunology, 5(Jun), 267-1-267-7. DOI Scopus12 WoS10 Europe PMC8
2013	Alsharifi, M., Koskinen, A., Wijesundara, D., Bettadapura, J., & Mullbacher, A. (2013). MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One, 8(6), e68458-1-e68458-8. DOI Scopus3 WoS3 Europe PMC3
2013	Stevens, N., Fraser, C., Alsharifi, M., Brown, M., Diener, K., & Hayball, J. (2013). An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant. PLoS One, 8(7), 1-10. DOI Scopus10 WoS7 Europe PMC5
2011	Furuya, Y., Chan, J., Wan, E., Koskinen, A., Diener, K., Hayball, J., . . . Alsharifi, M. (2011). Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. PLoS One, 6(10), e25765-1-e25765-12. DOI Scopus17 WoS16 Europe PMC12
2010	Wijesundara, D., Kumar, S., Alsharifi, M., Mullbacher, A., & Regner, M. (2010). Antigen-specific activation thresholds of CD8⁺ T cells are independent of IFN-I-mediated partial lymphocyte activation. International Immunology, 22(9), 757-767. DOI Scopus3 WoS3 Europe PMC3
2010	Furuya, Y., Chan, J., Regner, M., Lobigs, M., Koskinen, A., Kok, T., . . . Alsharifi, M. (2010). Cytoxic T cells are the predominant players providing cross-protective immunity induced by y-irradiated influenza A viruses. Journal of Virology, 84(9), 4212-4221. DOI Scopus71 WoS69 Europe PMC58
2010	Furuya, Y., Regner, M., Lobigs, M., Koskinen, A., Mullbacher, A., & Alsharifi, M. (2010). Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations. Journal of General Virology, 91(6), 1450-1460. DOI Scopus66 WoS58 Europe PMC42
2010	Alsharifi, M., & Mullbacher, A. (2010). The γ-irradiated influenza vaccine and the prospect of producing safe vaccines in general. Immunology and Cell Biology, 88(2), 103-104. DOI Scopus43 WoS39 Europe PMC32
2009	Lobigs, M., Larena, M., Alsharifi, M., Lee, E., & Pavy, M. (2009). Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. Journal of Virology, 83(6), 2436-2445. DOI Scopus49 WoS40 Europe PMC34
2009	Alsharifi, M., Furuya, Y., Bowden, T., Lobigs, M., Koskinen, A., Regner, M., . . . Mullbacher, A. (2009). Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections. PLoS One, 4(4), 1-6. DOI Scopus56 WoS51 Europe PMC46
2008	Alsharifi, M., Lobigs, M., Bettadapura, J., Koskinen, A., & Mullbacher, A. (2008). Restricted Semliki Forest virus replication in communication perforin and Fas-ligand double-deficient mice. Journal of General Virology, 89(8), 1942-1944. DOI Scopus3 WoS3 Europe PMC2
2008	Alsharifi, M., Muellbacher, A., & Regner, M. (2008). Interferon type I responses in primary and secondary infections. Immunology and Cell Biology, 86(3), 239-245. DOI Scopus54 WoS50 Europe PMC50
2007	Budd, A., Alleva, L., Alsharifi, M., Koskinen, A., Smythe, V., Müllbacher, A., . . . Clark, I. (2007). Increased survival after gemfibrozil treatment of severe mouse influenza. Antimicrobial Agents and Chemotherapy, 51(8), 2965-2968. DOI Scopus85 WoS81 Europe PMC68
2006	Alsharifi, M., Regner, M., Blanden, R., Lobigs, M., Lee, E., Koskinen, A., & Müllbacher, A. (2006). Exhaustion of type I interferon response following an acute viral infection. Journal of Immunology, 177(5), 3235-3241. DOI Scopus29 WoS27 Europe PMC21
2006	Alsharifi, M., Lobigs, M., Simon, M. M., Kersten, A., Müller, K., Koskinen, A., . . . Müllbacher, A. (2006). NK cell-mediated immunopathology during an acute viral infection of the CNS. European Journal of Immunology, 36(4), 887-896. DOI Scopus30 WoS27 Europe PMC24
2006	Müllbacher, A., Lobigs, M., Alsharifi, M., & Regner, M. (2006). Cytotoxic T-cell immunity as a target for influenza vaccines. Lancet Infectious Diseases, 6(5), 255-256. DOI Scopus15 WoS13 Europe PMC12
2005	Rosen, D. B., Bettadapura, J., Alsharifi, M., Mathew, P. A., Warren, H. S., & Lanier, L. L. (2005). Cutting edge: Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. Journal of Immunology, 175(12), 7796-7799. DOI Scopus223 WoS205 Europe PMC183
2005	Alsharifi, M., Lobigs, M., Regner, M., Lee, E., Koskinen, A., & Müllbacher, A. (2005). Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection. Journal of Immunology, 175(7), 4635-4640. DOI Scopus41 WoS38 Europe PMC37

Conference Papers

Year	Citation
2016	David, S., Paton, J., McColl, S., & Alsharifi, M. (2016). Gamma-irradiated influenza A virus vaccine: irradiation conditions & vaccine efficacy. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 1236). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2007	Alsharifi, M., Regner, M., Blanden, R., Lobigs, M., Lee, E., Koskinen, A., & Muellbacher, A. (2007). Interferon type-I responses in primary and secondary viral infections. In CYTOKINE Vol. 39 (pp. 1). San Francisco, CA: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. DOI WoS1
2005	Alsharifi, M., Lobigs, M., Regner, M., Koskinen, E. L. A., & Müllbacher, A. (2005). Exhaustion of type-I interferon response following an acute viral infection. In TISSUE ANTIGENS Vol. 66 (pp. 345-346). Melbourne, AUSTRALIA: BLACKWELL PUBLISHING.

Conference Items

Year	Citation
2019	David, S. C., Laan, Z., Chen, A., Hirst, T., Paton, J., & Alsharifi, M. (2019). A novel co-vaccination strategy to provide serotype-independent protection against pneumococcal infections. Poster session presented at the meeting of 14th European Meeting on the Molecular Biology of the Pneumococcus (Europneumo). Greifswald, Germany.
2019	David, S. C., Singleton, E., Laan, Z., Chen, A., Hirst, T., Comerford, I., . . . Alsharifi, M. (2019). A novel co-vaccination strategy for cross-reactive immunity against influenza A & pneumococcal infections. Poster session presented at the meeting of Australian & New Zealand Society for Immunology (ASI) Meeting. Adelaide, Australia.
2018	David, S. C., Babb, R., McColl, S., Paton, J., & Alsharifi, M. (2018). Bi-directional adjuvant activity of co-administered pneumococcal and influenza A vaccines. Poster session presented at the meeting of International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11). Melbourne, Australia.
2017	David, S. C., Paton, J., McColl, S., & Alsharifi, M. (2017). Enhancement of influenza-specific immunity following intranasal co-administration of whole inactivated Influenza and pneumococcal vaccines. Poster session presented at the meeting of Australian Virology Society (AVS).
2016	David, S. C., Lau, J., Singleton, E., Paton, J., McColl, S., & Alsharifi, M. (2016). THE EFFECT OF GAMMA-IRRADIATION CONDITIONS ON THE IMMUNOGENICITY OF WHOLE-INACTIVATED INFLUENZA A VIRUS VACCINE. Poster session presented at the meeting of Adelaide Immunology Retreat (AIR-12) Meeting. Adelaide, Australia.
2016	Fenix, K., Kara, E., Bastow, C., Gregor, C., McKenzie, D., Norton, T., . . . McColl, S. (2016). CCR2 Is critical for memory CD8 T cell generation following influenza A virus infection. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL.

Patents

Year	Citation
2021	David, S., Alsharifi, M., Brazel, E., Hirst, T., & Paton, J. (2021). US20210361758A1, Streptococcal vaccines and methods for use. US.
2021	Brazel, E., Alsharifi, M., David, S., Hirst, T., & Paton, J. (2021). US20210361757A1, Streptococcal vaccine formulations and uses thereof. US.
2016	Alsharifi, M., Babb, R., Chen, A. Y., David, S. C., Hirst, T. R., Ogunniyi, A. D., & Paton, J. C. (2016). 050231, Streptococcal Vaccine. Australia.
2015	Alsharifi, M., Babb, R., Chen, A. Y., Hirst, T. R., Ogunniyi, A. D., & Paton, J. C. (2015). 2015901098, Streptococcal Vaccine. Australia.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2024	Principal Supervisor	A combination vaccine targeting Newcastle Disease Virus and Influenza A virus for poultry	Doctor of Philosophy	Doctorate	Full Time	Ms Yimin Chuah
2024	Co-Supervisor	Development of a novel whole-inactivated Streptococcal vaccine	Doctor of Philosophy	Doctorate	Full Time	Ms Rachel Chin
2023	Co-Supervisor	Developing a novel cross-protective, inactivated vaccine against non-typeable Haemophilus influenzae	Doctor of Philosophy	Doctorate	Full Time	Ms Carla Ruth Gallasch
2023	Principal Supervisor	Immune responses induced by inactivated vaccines	Doctor of Philosophy	Doctorate	Full Time	Miss Mariana Couto Moniz
2023	Principal Supervisor	Assessing the Oncolytic Activity of Inactivated Vaccines	Master of Philosophy	Master	Full Time	Miss Amal Hazem Mohammed Nour Afify Moh Mostafa

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2020 - 2024	Principal Supervisor	Enhancing the Stability and Immunogenicity of a Whole-Cell Pneumococcal Vaccine	Doctor of Philosophy	Doctorate	Full Time	Ms Chloe Gates
2018 - 2020	Principal Supervisor	Humoral responses induced by an enzymatically active, whole-cell killed pneumococcal vaccine	Master of Philosophy	Master	Full Time	Miss Zoe Laan
2017 - 2020	Principal Supervisor	Sterility and Immunogenicity of Gamma Irradiated Respiratory Viruses	Doctor of Philosophy	Doctorate	Full Time	Miss Eve Victoria Singleton
2016 - 2018	Principal Supervisor	Enhancement of pathogen-specific immunity following co-administration of whole inactivated respiratory vaccines	Doctor of Philosophy	Doctorate	Full Time	Dr Shannon Christa David
2014 - 2014	Co-Supervisor	Chikungunya Virus: Evidence for Global Policy, Practice and Research in Disease Management, Surveillance and Mosquito Control	Doctor of Philosophy	Doctorate	Full Time	Miss Zhili Chen
2013 - 2017	Co-Supervisor	The role of chemokine receptors CCR2 and CXCR5 in CD8 positive T cell biology	Doctor of Philosophy	Doctorate	Full Time	Dr Kevin Aaron Fenix
2012 - 2017	Principal Supervisor	Development of a Novel Co-vaccination Approach for Pneumococcal and Influenza Infections	Doctor of Philosophy	Doctorate	Full Time	Miss Rachelle Babb
2012 - 2013	Principal Supervisor	Pre-existing strain specific neutralising antibodies abrogates the induction of interferon type I and cytotoxic T cell responses to subsequent homotypic influenza A virus challenge	Master of Philosophy	Master	Full Time	Miss Jennifer Chan

Editorial Boards

Date Role Editorial Board Name Institution Country

2012 - ongoing Editor PLoS One - -

Date	Role	Editorial Board Name	Institution	Country
2012 - ongoing	Editor	PLoS One	-	-

Position: Senior Lecturer
Phone: 83134632
Email: mohammed.alsharifi@adelaide.edu.au
Fax: 83134362
Campus: North Terrace
Building: Molecular Life Sciences, floor 5
Org Unit: Molecular and Biomedical Science

Dr Mohammed Alsharifi

Appointments

Language Competencies

Education

Postgraduate Training

Research Interests

Journals

Conference Papers

Conference Items

Patents

Current Higher Degree by Research Supervision (University of Adelaide)

Past Higher Degree by Research Supervision (University of Adelaide)

Editorial Boards

Connect With Me

External Profiles