
Associate Professor Michael Lardelli
Associate Professor
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
We exploit advanced 'omics technologies (e.g. trancriptomics, proteomics, metabolomics) to investigate the mechanisms underlying Alzheimer's disease using zebrafish models of mutations causing the disease. Our main focus is the gene PRESENILIN 1 in which most such mutations occur.
Recently our research has expanded into investigation of a form of childhood dementia, Sanfilippo syndrome, as we examine commonalities between it and Alzheimer's disease.
Research projects in our laboratory commonly combine molecular biology with zebrafish genome manipulation and behavioural analysis. Bioinformatics analysis is conducted in collaboration with Karissa Barthelson.
In 2023 Michael Lardelli has taken over responsibility for the University of Adelaide's Drosophila melanogaster ("fruit fly") facility. Consequently, research into Alzheimer's disease and Sanfilippo syndrome has also begun using this organism.
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Appointments
Date Position Institution name 2015 - ongoing Associate Professor in Genetics University of Adelaide -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Swedish Can read, write, speak and understand spoken -
Education
Date Institution name Country Title 1987 - 1991 Council for National Academic Awards United Kingdom Ph.D. 1981 - 1984 University of Sydney Australia B.Sc. (Hons) -
Postgraduate Training
Date Title Institution Country 1994 - 1995 ESF Postdoctoral Fellowship Uppsala University Sweden 1991 - 1994 EMBO Long Term Postodoctoral Fellowship Karolinska Institute Sweden -
Research Interests
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Journals
Year Citation 2025 Barthelson, K., Protzman, R. A., Snel, M. F., Hemsley, K., & Lardelli, M. (2025). Multi-omics analyses of early-onset familial Alzheimer's disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.. Biochim Biophys Acta Mol Basis Dis, 1871(3), 167651.
2024 Lardelli, M., Baer, L., Hin, N., Allen, A., Pederson, S. M., & Barthelson, K. (2024). The Use of Zebrafish in Transcriptome Analysis of the Early Effects of Mutations Causing Early Onset Familial Alzheimer's Disease and Other Inherited Neurodegenerative Conditions. Journal of Alzheimer's Disease, 99(s2), S367-S381.
Scopus3 Europe PMC22024 Baer, L., Barthelson, K., Postlethwait, J. H., Adelson, D. L., Pederson, S. M., & Lardelli, M. (2024). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. PLoS Computational Biology, 20(2 February), 27 pages.
Europe PMC12024 Hillman, C., Fontana, B. D., Amstislavskaya, T. G., Gorbunova, M. A., Altenhofen, S., Barthelson, K., . . . Parker, M. O. (2024). Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study.. Res Sq.
2023 Barthelson, K., Protzman, R., Snel, M., Hemsley, K., & Lardelli, M. (2023). Multi-omics analyses of early-onset familial Alzheimer’s disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.
2023 Baer, L., Barthelson, K., Postlethwait, J., Adelson, D., Pederson, S., & Lardelli, M. (2023). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. bioRxiv.
2023 Lardelli, M. (2023). An Alternative View of Familial Alzheimer’s Disease Genetics.
2023 Lardelli, M. (2023). An Alternative View of Familial Alzheimer’s Disease Genetics.
2023 Ha, T. T., Burgess, R., Newman, M., Moey, C., Mandelstam, S. A., Gardner, A. E., . . . Corbett, M. A. (2023). Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes, 14(8), 1565.
Scopus2 Europe PMC12023 Allen, A. G., Barthelson, K., & Lardelli, M. (2023). pHAPE: a plasmid for production of DNA size marker ladders for gel electrophoresis.. Biol Methods Protoc, 8(1), bpad015.
Scopus12023 Gerken, E., Ahmad, S., Rattan, L., Hemsley, K., Hemsley, K., Suo, S., . . . Lardelli, M. (2023). Zebrafish models of Mucopolysaccharidosis types IIIA, B, & C show hyperactivity and changes in oligodendrocyte state.
2023 Lardelli, M. (2023). An Alternative View of Familial Alzheimer's Disease Genetics.. Journal of Alzheimer's disease : JAD, 96(1), 1-27.
Scopus8 WoS1 Europe PMC72022 Barthelson, K., Newman, M., & Lardelli, M. (2022). Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism. Disease Models and Mechanisms, 15(1), 1-14.
Scopus8 WoS1 Europe PMC32022 Allen, A., Barthelson, K., & Lardelli, M. (2022). pHAPE: a plasmid for production of DNA size marker ladders for gel electrophoresis.
2021 Coulson, M., Searle, I., Richards, R., Tucker, M. R., Bakaj, N., Bertozzi, T., . . . Lardelli, M. (2021). Multiple learning and administrative advantages when an advanced course in genetics adopted a “flipped-classroom” format with continuous, online assessment.
2021 Jayne, T., Newman, M., Baer, L., & Lardelli, M. (2021). The evolved divergence of γ-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish. BMC Research Notes, 14(1), 1-5.
2021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Differential effects of loss of<i>park7</i>activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s disease.
2021 Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2021). In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains. Journal of Alzheimer's Disease Reports, 5(1), 395-404.
Scopus9 WoS5 Europe PMC82021 Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). PRESENILIN 1 mutations causing early-onset familial alzheimer's disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction. Journal of Alzheimers Disease, 82(1), 327-347.
Scopus8 WoS2 Europe PMC72021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.. Mol Brain, 14(1), 83.
Scopus8 WoS6 Europe PMC72021 Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., . . . Lardelli, M. (2021). Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in Genetics, 12, 1-11.
Scopus3 Europe PMC52021 Hin, N., Newman, M., Pederson, S., & Lardelli, M. (2021). Iron responsive element-mediated responses to iron dyshomeostasis in Alzheimer's disease. Journal of Alzheimers Disease, 84(4), 1-34.
Scopus16 WoS6 Europe PMC232021 Hin, N., Newman, M., Pederson, S., & Lardelli, M. (2021). Iron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer's disease. Journal of Alzheimer's Disease, 84(4), 1597-1630.
Europe PMC22021 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2021). Brain transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial alzheimer's disease indicates early effects on mitochondrial and ribosome function. Journal of Alzheimer's Disease, 79(3), 1105-1119.
Scopus8 WoS4 Europe PMC72021 Barthelson, K., Newman, M., Nowell, C. J., & Lardelli, M. (2021). No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene. Molecular Brain, 14(1), 22-1-22-4.
Scopus1 WoS1 Europe PMC12021 Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). <i>PRESENILIN 1</i>mutations causing early-onset familial Alzheimer’s disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction.
2021 Barthelson, K., Newman, M., & Lardelli, M. (2021). Comparative analysis of Alzheimer’s disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress.
2021 Dong, Y., Newman, M., Pederson, S. M., Barthelson, K., Hin, N., & Lardelli, M. (2021). Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis. BMC Genomics, 22(1), 211-1-211-16.
Scopus11 WoS6 Europe PMC62021 Moussavi Nik, S. H., Porter, T., Newman, M., Bartlett, B., Khan, I., Sabale, M., . . . Verdile, G. (2021). Relevance of a truncated PRESENILIN 2 transcript to Alzheimer's disease and neurodegeneration.. Journal of Alzheimer's Disease, 80(4), 1-11.
Scopus4 WoS2 Europe PMC42020 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease. biorxiv.
2020 Jiang, H., Pederson, S. M., Newman, M., Dong, Y., & Lardelli, M. (2020). Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene<i>psen2</i>.
2020 Newman, M., Moussavi Nik, S. H., Sutherland, G. T., Hin, N., Kim, W. S., Halliday, G. M., . . . Lardelli, M. (2020). Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1. Human Molecular Genetics, 29(14), 2379-2394.
Scopus11 WoS8 Europe PMC102020 Barthelson, K., Newman, M., & Lardelli, M. (2020). Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease. Journal of Alzheimer’s Disease Reports, 4(1), 123-140.
Scopus24 WoS13 Europe PMC252020 Jiang, H., Pederson, S. M., Newman, M., Dong, Y., Barthelson, K., & Lardelli, M. (2020). Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2. PLoS One, 15(7), e0232559-1-e0232559-25.
Scopus7 WoS3 Europe PMC72020 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer's disease.. Molecular brain, 13(1), 142.
Scopus25 WoS14 Europe PMC222020 Barthelson, K., Pederson, S., Newman, M., & Lardelli, M. (2020). Transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial Alzheimer’s disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brains. biorxiv.
Europe PMC12020 Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2020). Frameshift and frame-preserving mutations in zebrafish presenilin 2 affect different cellular functions in young adult brains.
Europe PMC22020 Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Moussavi Nik, S. H., . . . Lardelli, M. (2020). Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. PloS one, 15(1), e0227258.
Scopus23 WoS17 Europe PMC242019 Newman, M., Hin, N., Pederson, S., & Lardelli, M. (2019). A familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene affects brain energy production.
2019 Newman, M., Nik, H. M., Sutherland, G., Hin, N., Kim, W., Halliday, G., . . . Lardelli, M. (2019). Accelerated loss of hypoxia response in zebrafish with familial Alzheimer’s disease-like mutation of Presenilin 1.
2019 Newman, M., Hin, N., Pederson, S., & Lardelli, M. (2019). Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular Brain, 12(1), 1-5.
Scopus21 WoS18 Europe PMC192019 Braggin, J. E., Bucks, S. A., Course, M. M., Smith, C. L., Sopher, B., Osnis, L., . . . Jayadev, S. (2019). Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Annals of Clinical and Translational Neurology, 6(4), 762-777.
Scopus29 WoS21 Europe PMC212018 Lumsden, A., Rogers, J., Majd, S., Newman, M., Sutherland, G., Verdile, G., & Lardelli, M. (2018). Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease. Frontiers in Neuroscience, 12(AUG), 533-1-533-21.
Scopus38 WoS29 Europe PMC322018 Nik, S. H. M., Newman, M., Lumsden, A., Jayne, T., & Lardelli, M. (2018). HMGA1 zebrafish co-orthologue hmga1b can modulate p53-dependent cellular responses but is unable to control the alternative splicing of psen1.
2018 Jiang, H., Newman, M., & Lardelli, M. (2018). The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. PLoS ONE, 13(10), e0206155-1-e0206155-20.
Scopus21 WoS16 Europe PMC132018 Jiang, H., Jayadev, S., Lardelli, M., & Newman, M. (2018). A Review of the Familial Alzheimer's Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1. Journal of Alzheimer's Disease, 66(4), 1323-1339.
Scopus19 WoS11 Europe PMC152018 Ratnayake, D., Newman, M., & Lardelli, M. (2018). Degenerate codon mixing for PCR-based manipulation of highly repetitive sequences. BMC Research Notes, 11(1), 202-1-202-7.
Scopus1 Europe PMC12018 Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Zhou, X., . . . Lardelli, M. (2018). Accelerated brain aging towards transcriptional inversion in a zebrafish model of familial Alzheimer's disease. BioRxiv, OnlinePubl.
Europe PMC12017 Newman, M., Halter, L., Lim, A., & Lardelli, M. (2017). Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer’s disease. PLoS ONE, 12(6), e0179859-1-e0179859-17.
Scopus3 WoS2 Europe PMC22016 Ebrahimie, E., Moussavi Nik, S., Newman, M., Van Der Hoek, M., & Lardelli, M. (2016). The Zebrafish equivalent of Alzheimer's disease-associated PRESENILIN Isoform PS2V regulates inflammatory and other responses to hypoxic stress. Journal of Alzheimer's Disease, 52(2), 581-608.
Scopus14 WoS12 Europe PMC132016 Jayne, T., Newman, M., Verdile, G., Sutherland, G., Münch, G., Musgrave, I., . . . Lardelli, M. (2016). Evidence for and against a pathogenic role of reduced γ-secretase activity in familial Alzheimer's disease. Journal of Alzheimer's Disease, 52(3), 781-799.
Scopus36 WoS27 Europe PMC342016 Richards, R., Robertson, S., O'Keefe, L., Fornarino, D., Scott, A., Lardelli, M., & Baune, B. (2016). The enemy within: innate surveillance-mediated cell death, the common mechanism of neurodegenerative disease. Frontiers in Neuroscience, 10(MAY), 193-1-193-20.
Scopus34 WoS27 Europe PMC252015 Moussavi Nik, S., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., . . . Lardelli, M. (2015). Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678.
Scopus26 WoS22 Europe PMC212015 Lim, A., Moussavi Nik, S., Ebrahimie, E., & Lardelli, M. (2015). Analysis of nicastrin gene phylogeny and expression in zebrafish. Development Genes and Evolution, 225(3), 171-178.
Scopus6 WoS4 Europe PMC42014 Newman, M., Ebrahimie, E., & Lardelli, M. (2014). Using the zebrafish model for Alzheimer's disease research. Frontiers in Genetics, 5(JUN), 189-1-189-10.
Scopus121 WoS92 Europe PMC672014 Ganesan, S., Moussavi Nik, S., Newman, M., & Lardelli, M. (2014). Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family. Experimental Cell Research, 328(1), 228-237.
Scopus12 WoS11 Europe PMC62014 Nik, S., Croft, K., Mori, T., & Lardelli, M. (2014). The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish, 11(3), 248-254.
Scopus13 WoS10 Europe PMC82014 Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Nik, S., . . . Lardelli, M. (2014). Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Human Molecular Genetics, 23(3), 602-617.
Scopus47 WoS40 Europe PMC332014 Moussavi Nik, S. H., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., & Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(1), 767-1-767-9.
Scopus21 Europe PMC72014 Klarić, T., Lardelli, M., Key, B., Koblar, S., & Lewis, M. (2014). Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain. Frontiers in Neuroanatomy, 8(DEC), 148-1-148-13.
Scopus19 WoS16 Europe PMC132013 Wilson, L., & Lardelli, M. (2013). The development of an in vivo γ-secretase assay using zebrafish embryos. Journal of Alzheimer's Disease, 36(3), 521-534.
Scopus9 WoS8 Europe PMC42013 Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., . . . Verdile, G. (2013). The Guinea Pig as a model for sporadic Alzheimer's Disease (AD): the impact of cholesterol intake on expression of AD-related genes. PLoS One, 8(6), 1-12.
Scopus35 WoS31 Europe PMC302012 Avdesh, A., Chen, M., Martin-Iverson, M., Mondal, A., Ong, D., Rainey-Smith, S., . . . Martins, R. (2012). Regular care and maintenance of a Zebrafish (Danio rerio) laboratory: an introduction. Journal of Visualized Experiments, (69), 1-8.
Scopus342 WoS230 Europe PMC1442012 Newman, M., Nornes, S., Martins, R., & Lardelli, M. (2012). Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19.
Scopus8 WoS5 Europe PMC52012 Moussavi Nik, S., Wilson, L., Newman, M., Croft, K., Mori, T., Musgrave, I., & Lardelli, M. (2012). The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Journal of Alzheimer's Disease, 28(3), 515-530.
Scopus50 WoS23 Europe PMC372012 Avdesh, A., Martin-Iverson, M., Mondal, A., Chen, M., Askraba, S., Newman, M., . . . Martins, R. (2012). Evaluation of color preference in zebrafish for learning and memory. Journal of Alzheimer's Disease, 28(2), 459-469.
Scopus111 WoS92 Europe PMC522012 Chen, M., Tegg, M., Avdesh, A., Mondal, A., Lardelli, M., Verdile, G., & Martins, R. (2012). P4‐121: Analysis of insulin‐degrading enzyme (IDE) expression and function in zebrafish embryos. Alzheimer's & Dementia, 8(4S_Part_18).
2011 Sugano, Y., & Lardelli, M. (2011). Identification and expression analysis of the zebrafish orthologue of Klotho. Development Genes and Evolution, 221(3), 179-186.
Scopus15 WoS12 Europe PMC102011 Wells, S., Nornes, S., & Lardelli, M. (2011). Transgenic zebrafish recapitulating tbx16 gene early developmental expression. PLoS One, 6(6), e21559-1-e21559-6.
Scopus13 WoS10 Europe PMC142011 Moussavi Nik, S., Newman, M., & Lardelli, M. (2011). The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Experimental Cell Research, 317(11), 1503-1512.
Scopus23 WoS20 Europe PMC202011 Newman, M., Verdile, G., Martins, R., & Lardelli, M. (2011). Zebrafish as a tool in Alzheimer's disease research. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1812(3), 346-352.
Scopus66 WoS45 Europe PMC352010 Newman, M., & Lardelli, M. (2010). A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos. BMC Research Notes, 3(1), 282-286.
Scopus7 Europe PMC62010 Wells, S., Conran, J., Tamme, R., Gaudin, A., Webb, J., & Lardelli, M. (2010). Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord. Experimental Cell Research, 316(19), 3292-3303.
Scopus1 WoS1 Europe PMC62010 Newman, M., Wilson, L., Camp-Dotlic, E., Verdile, G., Martins, R., & Lardelli, M. (2010). A zebrafish melanophore model of amyloidβ toxicity. Zebrafish, 7(2), 155-159.
Scopus19 WoS19 Europe PMC122010 Aleklett, K., Hook, M., Jakobsson, K., Lardelli, M., Snowden, S., & Soderbergh, B. (2010). The peak of the oil age - Analyzing the world oil production reference scenario in world energy outlook 2008. Energy Policy, 38(3), 1398-1414.
Scopus274 WoS2032009 Chen, M., Martins, R., & Lardelli, M. (2009). Complex splicing and neural expression of duplicated Tau genes in zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317.
Scopus50 WoS41 Europe PMC302009 Henshall, T., Tucker, B., Lumsden, A., Nornes, S., Lardelli, M., & Richards, R. (2009). Selective neuronal requirement for Huntingtin in the developing zebrafish. Human Molecular Genetics, 18(24), 4830-4842.
Scopus41 WoS37 Europe PMC322009 Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., & Lardelli, M. (2009). Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 316(16), 2791-2801.
Scopus46 WoS40 Europe PMC282009 Newman, M., Tucker, B., Nornes, S., Ward, A., & Lardelli, M. (2009). Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's Disease pathogenesis. Journal of Alzheimer's Disease, 16(1), 133-147.
Scopus26 WoS25 Europe PMC192009 Nornes, S., Tucker, B., & Lardelli, M. (2009). Zebrafish aplnra functions in epiboly. BMC Research Notes, 2(1), 1-6.
Scopus7 Europe PMC62009 Lardelli, M. (2009). Mining the data on coal. Science, 324(5929), 880-881.
Scopus6 WoS5 Europe PMC12009 Newman, M., Tucker, B., Nornes, S., Ward, A., & Lardelli, M. (2009). Erratum: Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis (Journal of Alzheimer's Disease (2009) 16:1 (133-147)). Journal of Alzheimer's Disease, 18(4), 993.
2008 Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., . . . Lardelli, M. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412.
Scopus45 WoS40 Europe PMC312007 Khut, P., Tucker, B., Lardelli, M., & Wood, S. (2007). Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, Usp9. Zebrafish, 4(2), 95-101.
Scopus12 WoS10 Europe PMC112007 Tucker, B., & Lardelli, M. (2007). A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. Zebrafish, 4(2), 113-116.
Scopus125 WoS99 Europe PMC842007 Belle, L., Wadham, C., Crocker, L., Lardelli, M., & Khew-Goodall, Y. (2007). The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development. Journal of Cell Biology, 178(7), 1223-1235.
Scopus73 WoS68 Europe PMC562007 Lumsden, A., Henshall, T., Dayan, S., Lardelli, M., & Richards, R. (2007). Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Human Molecular Genetics, 16(16), 1905-1920.
Scopus135 WoS123 Europe PMC992007 Newman, M., Musgrave, I., & Lardelli, M. (2007). Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1772(3), 285-297.
Scopus117 WoS103 Europe PMC742007 Lardelli, M. (2007). Scientists need to confront economists about peak oil. Nature, 446(7133), 257.
Scopus3 WoS3 Europe PMC12007 Tucker, B., Hepperle, C., Kortschak, R., Rainbird, B., Wells, S., Oates, A., & Lardelli, M. (2007). Zebrafish Angiotensin II receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia. Gene Expression Patterns, 7(3), 258-265.
Scopus27 WoS27 Europe PMC252007 Newman, M., Musgrave, I. F., & Lardelli, M. (2007). Corrigendum to "Alzheimer disease: Amyloidogenesis, the presenilins and animal models" [Biochim. Biophys. Acta 1772 (2007) 285-297] (DOI:10.1016/j.bbadis.2006.12.001). Biochimica et Biophysica Acta - Molecular Basis of Disease, 1772(9), 1118.
Scopus12006 Tucker, B., Richards, R., & Lardelli, M. (2006). Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. Human Molecular Genetics, 15(23), 3446-3458.
Scopus108 WoS104 Europe PMC872004 Tucker, B., Richards, R., & Lardelli, M. (2004). Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships. Development Genes and Evolution, 214(11), 567-574.
Scopus33 WoS28 Europe PMC262004 Scholpp, S., Groth, C., Lohs, C., Lardelli, M., & Brand, M. (2004). Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Development Genes and Evolution, 214(6), 285-295.
Scopus61 WoS53 Europe PMC492003 Lardelli, M. (2003). The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga. Development Genes and Evolution, 213(10), 519-522.
Scopus17 WoS17 Europe PMC162003 Camp-Dotlic, E., Badhwar, P., Mann, G., & Lardelli, M. (2003). Expression analysis of a Tyrosinase promoter sequence in zebrafish. Pigment Cell Research, 16(2), 117-126.
Scopus14 WoS15 Europe PMC92003 Camp-Dotlic, E., Hope, R., Kortschak, R., Cox, T., & Lardelli, M. (2003). Expression of three spalt (sal) gene homologues in zebrafish embryos. Development Genes and Evolution, 213(1), 35-43.
Scopus23 WoS20 Europe PMC212003 Nornes, S., Groth, C., Camp-Dotlic, E., Ey, P., & Lardelli, M. (2003). Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Experimental Cell Research, 289(1), 124-132.
Scopus50 WoS42 Europe PMC302003 Lardelli, M. (2003). Something fishy in 21st century genomics. Todays Life Science, 15, 20-23. 2002 Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermal determinant spadetail. BMC Developmental Biology, 2(9), www 1-www 13.
2002 Groth, C., Nornes, S., Mc Carty, R., Tamme, R., & Lardelli, M. (2002). Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Development Genes and Evolution, 212(10), 486-490.
Scopus61 WoS52 Europe PMC382002 Groth, C., & Lardelli, M. (2002). The structure and function of vertebrate fibroblast growth factor receptor 1. International Journal of Developmental Biology, 46(4 Special Issue SI), 393-400.
Scopus76 WoS70 Europe PMC552002 Tamme, R., Wells, S., Conran, J. G., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermal determinant spadetail.. BMC developmental biology [electronic resource], 2(1), 9.
Scopus8 Europe PMC122002 Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermaldeterminant spadetail. BMC Developmental Biology, 2, 1-13.
Scopus152002 Kortschak, R. D., Tamme, R., & Lardelli, M. (2002). Erratum: Evolutionary analysis of vertebrate Notch genes (Development Genes and Evolution (2001) vol. 211 (350-354)). Development Genes and Evolution, 212(3), 158.
2001 Holland, L. Z., Rached, L. A., Tamme, R., Holland, N. D., Kortschak, D., Inoko, H., . . . Lardelli, M. (2001). Erratum: Characterization and developmental expression of the amphioxus homolog of Notch (AmnphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates (Developmental Biology (2001) 232:2 (495-507)). Developmental Biology, 233(1), 238.
Scopus12001 Jonsson, J., Xiang, Z., Pettersson, M., Lardelli, M., & Nilsson, G. (2001). Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. European Journal of Immunology, 31(11), 3240-3247.
Scopus47 WoS44 Europe PMC382001 Holland, L., Rached, L., Tamme, R., Holland, N., Inoko, H., Kortschak, R., . . . Lardelli, M. (2001). Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Developmental Biology, 232(2), 493-507.
Scopus51 WoS48 Europe PMC372001 Camp-Dotlic, E., & Lardelli, M. (2001). Tyrosinase gene expression in zebrafish embryos. Development Genes and Evolution, 211(3), 150-153.
Scopus71 WoS60 Europe PMC562001 Kortschak, R., Tamme, R., & Lardelli, M. (2001). Evolutionary analysis of vertebrate Notch genes. Development Genes and Evolution, 211(7), 350-354.
Scopus31 WoS30 Europe PMC262001 Tamme, R., Mills, K., Rainbird, B., Nornes, S., & Lardelli, M. (2001). Simple, directional cDNA cloning for in situ transcript hybridization screens. Biotechniques, 31(4), 938-946.
Scopus6 WoS5 Europe PMC52000 Tamme, R., Camp-Dotlic, E., Kortschak, R., & Lardelli, M. (2000). Non-specific, nested suppression PCR method for isolation of unknown flanking DNA. Biotechniques, 28(5), 895-902.
Scopus10 WoS8 Europe PMC61997 Westin, J., & Lardelli, M. (1997). Three novel Notch genes in zebrafish: Implications for vertebrate Notch gene evolution and function. Development Genes and Evolution, 207(1), 51-63.
Scopus123 WoS116 Europe PMC831997 Zhang, H. Y., Lardelli, M., & Ekblom, P. (1997). Sequence of zebrafish fibulin-1 and its expression in developing heart and other embryonic organs. Development Genes and Evolution, 207(5), 340-351.
Scopus16 WoS14 Europe PMC91997 Lardelli, M. (1997). Generation and PCR screening of bacteriophage gamma sublibraries enriched for rare clones (the "sublibrary method").. Methods in molecular biology (Clifton, N.J.), 67, 345-355.
Scopus3 Europe PMC11996 Lardelli, M., Williams, R., Mitsiadis, T., & Lendahl, U. (1996). Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mechanisms of Development, 59(2), 177-190.
Scopus94 WoS93 Europe PMC791995 Dahlstrand, J., Lardelli, M., & Lendahl, U. (1995). Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Developmental Brain Research, 84(1), 109-129.
Scopus463 WoS427 Europe PMC3561995 Mitsiadis, T. A., Lardelli, M., Lendahl, U., & Thesleff, I. (1995). Expression of Notch 1, 2, and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. Journal of Cell Biology, 130(2), 407-418.
Scopus158 WoS153 Europe PMC1261995 Williams, R., Lendahl, U., & Lardelli, M. (1995). Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mechanisms of Development, 53(3), 357-368.
Scopus147 WoS146 Europe PMC1091995 Lardelli, M. (1995). Residents’ rights. Nature, 378(6555), 330.
1995 Lardelli, M., Williams, R., & Lendahl, U. (1995). Notch-related genes in animal development. International Journal of Developmental Biology, 39(5), 769-780.
Scopus51 WoS50 Europe PMC341995 Lardelli, M. (1995). Discriminatory frontier policy. Nature, 376(6535), 12.
1994 Lardelli, M., Dahlstrand, J., & Lendahl, U. (1994). The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mechanisms of Development, 46(2), 123-136.
Scopus272 WoS275 Europe PMC2031994 Larsson, C., Lardelli, M., White, I., & Lendahl, U. (1994). The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation. Genomics, 24(2), 253-258.
Scopus89 WoS90 Europe PMC621994 Barlow, C., Meister, B., Lardelli, M., Lendahl, U., & Vennström, B. (1994). Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO Journal, 13(18), 4241-4250.
Scopus77 WoS76 Europe PMC501994 Lardelli, M., & Lendahl, U. (1994). Generating bacteriophage λ sublibraries enriched for rare clones. BioTechniques, 16(3), 420-422.
Scopus10 WoS10 Europe PMC81993 Lardelli, M., & Ish-Horowicz, D. (1993). Drosophila hairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains. Development, 118(1), 255-266.
Scopus12 WoS12 Europe PMC111993 Lardelli, M., & Lendahl, U. (1993). Motch A and Motch B — Two mouse Notch homologues coexpressed in a wide variety of tissues. Experimental Cell Research, 204(2), 364-372.
Scopus125 WoS133 Europe PMC871989 Rushlow, C. A., Hogan, A., Pinchin, S. M., Howe, K. M., Lardelli, M., & Ish-Horowicz, D. (1989). The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.. The EMBO journal, 8(10), 3095-3103.
Scopus206 WoS232 Europe PMC1561989 Johnson, M. A., Misra, R. M., Lardelli, M., Messina, M., Ephraums, C., Reeves, P. R., . . . Holmes, I. H. (1989). Synthesis in Escherichia coli of the major glycoprotein of human rotavirus: analysis of the antigenic regions. Gene, 84(1), 73-81.
Scopus10 WoS9 Europe PMC11 -
Books
Year Citation 2013 Aleklett, K., Lardelli, M., & Qvennerstedt, O. (2013). Peeking at peak oil (Vol. 9781461434245). Springer.
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Book Chapters
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Conference Papers
Year Citation 2015 Lardelli, M., Ebrahimie, E., Newman, M., Nik, S. M., & Hoek, M. V. D. (2015). Transcriptome analyses using human and zebrafish brain data reveal hypoxia as an important element in Alzheimer's disease. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 324). Cairns, AUSTRALIA: WILEY-BLACKWELL. 2006 Henshall, T. L., Lumsden, A. L., Lardelli, M. T., & Richards, R. I. (2006). A critical role for huntingtin in neural development. In INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE Vol. 24 (pp. 511). Banff, CANADA: PERGAMON-ELSEVIER SCIENCE LTD.
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Conference Items
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Theses
Year Citation 1991 Lardelli, M. (1991). Regulation and function of the pair-rule gene hairy in Drosophila melanogaster.. -
Preprint
Year Citation 2025 Baer, L., Lardelli, M., & Pederson, S. (2025). <i>tadar</i>: an R/Bioconductor package to reduce eQTL noise in differential expression analysis.
DOI
We receive funding from various sources including the NHMRC and private individuals.
Michael Lardelli teaches at all levels of genetics but specialising in developmental genetics, genetic manipulation of model organisms, and the genetics of Alzheimers' disease.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Principal Supervisor Molecular Genetic and Omics Analyses in Neurodegenerative Disease Research Doctor of Philosophy Doctorate Full Time Miss Xinya Wang 2024 Principal Supervisor Investigating early molecular Drivers of neurodegeneration by modelling Parkinson's disease in Zebrafish Doctor of Philosophy Doctorate Full Time Miss Angel Grace Allen 2022 Principal Supervisor Investigating Alzheimer's disease and MPS III mutant gene using Zebrafish and Drosophila genetic models Doctor of Philosophy Doctorate Full Time Mr Kaijing Xu 2021 Principal Supervisor Exogenous Ketogenic Therapy to Inhibit the Symptoms Caused by BACE1 in Drosophila and Protect Mitochondria Doctor of Philosophy Doctorate Full Time Mr Hao Huang -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2020 Principal Supervisor Transcriptome Analysis of Zebrafish Genetic Models to Reveal Early Molecular Drivers of Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Miss Nhi Hin 2017 - 2021 Principal Supervisor Investigating Alzheimer’s disease using zebrafish genetic models Doctor of Philosophy Doctorate Full Time Mr Yang Dong 2017 - 2021 Principal Supervisor Investigating the effects of mutations causative for early-onset familial Alzheimer’s disease using zebrafish as a model organism Doctor of Philosophy Doctorate Full Time Miss Karissa Barthelson 2014 - 2018 Principal Supervisor Identifying the pathological changes caused by familial Alzheimer’s disease-like mutations in zebrafish psen2 Doctor of Philosophy Doctorate Full Time Ms Haowei Jiang 2014 - 2020 Principal Supervisor Investigations of y-secretase substrates Amyloid precursor protein and p75 neurotrophin receptor in zebrafish Doctor of Philosophy Doctorate Full Time Tanya Jayne 2012 - 2016 Co-Supervisor An Investigation of the Role of CreB Deubiquitinating Enzyme in the Regulation of Carbon Metabolism in Aspergillus nidulans Doctor of Philosophy Doctorate Part Time Mr Md Ashiqul Alam 2011 - 2015 Principal Supervisor Analysis of the Subcellular Localization of Proteins Implicated in Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Miss Anne Hwee Ling Lim 2011 - 2015 Principal Supervisor Analysing the Biological Function of PS2V: An Aberrant Splicing Phenomenon or Evolutionarily Conserved Mechanism in Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Dr Seyyed Hani Moussavi Nik 2011 - 2015 Principal Supervisor ANALYSING THE ROLE OF AUTOPHAGY IN ALZHEIMER'S DISEASE PATHOGENESIS USING THE ZEBRAFISH MODEL SYSTEM Doctor of Philosophy Doctorate Full Time Mr Swamynathan Ganesan 2010 - 2011 Principal Supervisor Characterization of the zebrafish Orthologue of Klotho Master of Science Master Full Time Mr Yuya Sugano 2009 - 2012 Co-Supervisor Function and Evolution of the piRNA Pathway in the Amniote Gonad and Human Ovarian Cancer Doctor of Philosophy Doctorate Full Time Miss Shu Ly Lim 2009 - 2011 Principal Supervisor Molecular Responses to Low Oxygen Levels/Oxidative Stress in Zebrafish Master of Science Master Full Time Dr Seyyed Hani Moussavi Nik 2008 - 2009 Principal Supervisor Identification and Analysis of the Two Tau Paralogues in Zebrafish Master of Science Master Full Time Miss Mengqi Chen 2008 - 2011 Co-Supervisor From Model Organism to Industrial Workhorse Doctor of Philosophy Doctorate Part Time Mr Jai Denton 2008 - 2013 Principal Supervisor The analysis of Presenilin processing and activity with a focus on its implications for Alzheimer's disease pathogenesis using Danio Rerio as a model organism Doctor of Philosophy Doctorate Full Time Mr Lachlan James Wilson 2006 - 2010 Co-Supervisor Investigation of RNA-Mediated Pathogenic Pathways in a Drosophila Model of Expanded Repeat Disease Doctor of Philosophy Doctorate Full Time Dr Clare van Eyk 2006 - 2011 Co-Supervisor Tyrosine Phosphatase Pez: A Novel Regulator of TGFß Signalling, Epithelial-Mesenchymal Transition and Protein Secretion in Development and Cancer Doctor of Philosophy Doctorate Full Time Mrs Leila Belle 2005 - 2008 Principal Supervisor Analysis of Genes Implicated in Alzheimer's Disease Pathogenesis Using Danio Rerio as a Model Organism Doctor of Philosophy Doctorate Full Time Dr Morgan Newman 2004 - 2010 Co-Supervisor Huntingtin Function During Zebrafish (Danio rerio) Development Doctor of Philosophy Doctorate Full Time Miss Tanya Henshall 2003 - 2008 Principal Supervisor Zebrafish as a Model of Genetic Disease Doctor of Philosophy Doctorate Full Time Dr Ben Tucker 2003 - 2008 Co-Supervisor The Genetic and Biochemical Analysis of Drosophila Wwox Protein Function Doctor of Philosophy Doctorate Full Time Mr Alexander Colella 2002 - 2007 Co-Supervisor Investigating the Role of Huntingtin in Development and Disease using the Zebrafish Model Organism Doctor of Philosophy Doctorate Full Time Ms Amanda Lumsden 2001 - 2011 Principal Supervisor An Investigation into the Development and Patterning of Dorsal Longitudinal Ascending Interneurons in Danio Rerio Doctor of Philosophy Doctorate Full Time Dr Simon Wells 2000 - 2004 Principal Supervisor Alzheimer's disease genes in zebrafish (Danio rerio) Doctor of Philosophy Doctorate Full Time Mr Casper Groth 1999 - 2003 Principal Supervisor Development of a Transgenic Strategy for Facilitated Modifier Mutation Screening in Zebrafish Doctor of Philosophy Doctorate Part Time Dr Esther Camp-Dotlic 1998 - 2004 Principal Supervisor Development and application of novel cloning strategies for analysis of genes controlling embryo development Doctor of Philosophy Doctorate Full Time Mr Richard Tamme
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