NHMRC Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Internationally I actively contribute to my field by grant assessments, peer review for international journals, and via my assistant editor role. I have gained international/national media attention for my School, Institute, and University by gaining >$514,000 of ‘advertising space rate’ reaching an audience of ~4.7 million in Australia, and internationally via numerous international websites/blogs/social media (Pub #14 above). On a national level I represent the School, Institute, and University at the NHMRC by providing expert assessment of project grants, being an ECR observer at the NHMRC grant review panel 2016, PhD thesis examination, and membership of the NHMRC Research Translation Faculty. Locally I am a member of both the School of Medicine’s and Robinson Research Institute’s ECR research councils, which advocates at many levels for discipline ECRs, fulfil the role of ECR rep on the founding ANZ DOHaD council and am a founding council member for the Epigenetics Consortium of South Australia. I also regularly present at international/national scientific conferences, local scientific symposia, and local seminar series.
Date Position Institution name 2016 Robinson Research Institute’s Career Development Fellow University of Adelaide 2012 - 2015 NHMRC Early Career Fellow University of Adelaide 2009 - 2011 Grant Funded Research Oficer University of Adelaide 2002 - 2005 Grant Funded Scientist University of Adelaide 2000 - 2002 Research Assistant Novozymes (nee GroPep) Ltd Thebarton 1999 - 2000 Research Assistant to Dr HE Richardson University of Adelaide
Date Institution name Country Title 2012 University of Adelaide Australia Doctor of Philosophy (PhD 1999 University of Adelaide Australia Bachelor of Science (Hons) 1998 University of Adelaide Australia Bachelor of Science (BSc)
Year Citation 2017 Coman, D., Fullston, T., Shoubridge, C., Leventer, R., Wong, F., Nazaretian, S. ... McGillivray, G. (2017). X-Linked Lissencephaly With Absent Corpus Callosum and Abnormal Genitalia: An Evolving Multisystem Syndrome With Severe Congenital Intestinal Diarrhea Disease.. Child neurology open, 4, 2329048X17738625-.
2017 Robertson, S., Zhang, B., Chan, H., Sharkey, D., Barry, S., Fullston, T. & Schjenken, J. (2017). MicroRNA regulation of immune events at conception. Molecular Reproduction and Development, 84, 9, 1-12.
2017 Fullston, T., McPherson, N., Zander-Fox, D. & Lane, M. (2017). The most common vices of men can damage fertility and the health of the next generation. Journal of Endocrinology, 234, 2, F1-F6.
2017 McPherson, N., Lane, M., Sandeman, L., Owens, J. & Fullston, T. (2017). An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and microRNA expression in male offspring. Nutrients, 9, 2, 122-1-122-17.
2017 Akison, L., Andraweera, P., Bertoldo, M., Brown, H., Cuffe, J., Fullston, T. ... Schjenken, J. (2017). The current state of reproductive biology research in Australia and New Zealand: core themes from the Society for Reproductive Biology Annual Meeting, 2016. Reproduction, Fertility and Development, 29, 10, 1883-1889.
2016 McPherson, N., Fullston, T., Kang, W., Sandeman, L., Corbett, M., Owens, J. & Lane, M. (2016). Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers. Scientific Reports, 6, 1, 1-14.
2016 Fullston, T., Ohlsson-Teague, E., Print, C., Sandeman, L. & Lane, M. (2016). Sperm microRNA content is altered in a mouse model of male obesity, but the same suite of microRNAs are not altered in offspring's sperm. PLoS One, 11, 11, e0166076-1-e0166076-18.
2016 Dickinson, H., Moss, T., Gatford, K., Moritz, K., Akison, L., Fullston, T. ... Morrison, J. (2016). A review of fundamental principles for animal models of DOHaD research: an Australian perspective. Journal of Developmental Origins of Health and Disease, 7, 5, 449-472.
2016 Schjenken, J., Zhang, B., Chan, H., Sharkey, D., Fullston, T. & Robertson, S. (2016). miRNA Regulation of Immune Tolerance in Early Pregnancy. American Journal of Reproductive Immunology, 75, 3, 272-280.
2016 Fullston, T. & Evans, J. (2016). 'The Biggest Fertility Issue' in Special Issue 'Fertility in the 21st Century'. M. Gonzalez (Ed.). Australasian Science (Magazine), 37, 1, 23-25. 2015 McPherson, N., Bell, V., Zander-Fox, D., Fullston, T., Wu, L., Robker, R. & Lane, M. (2015). When two obese parents are worse than one! Impacts on embryo and fetal development. American Journal of Physiology: Endocrinology and Metabolism, 309, 6, E568-E581.
2015 McPherson, N., Owens, J., Fullston, T. & Lane, M. (2015). Preconception diet or exercise interventions in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. American journal of physiology: Endocrinology and metabolism, 308, 9, E805-E821.
2015 Fullston, T., McPherson, N., Owens, J., Kang, W., Sandeman, L. & Lane, M. (2015). Paternal obesity induces metabolic and sperm disturbances in male offspring that are exacerbated by their exposure to an "obesogenic" diet. Physiological Reports, 3, 3, e12336-1-e12336-14.
2015 Zander-Fox, D., Fullston, T., McPherson, N., Sandeman, L., Kang, W., Good, S. ... Lane, M. (2015). Reduction of mitochondrial function by FCCP during mouse cleavage stage embryo culture reduces birth weight and impairs the metabolic health of offspring. Biology of Reproduction, 92, 5, 124-1-124-11.
2015 Fullston, T., Shehadeh, H., Sandeman, L., Kang, W., Wu, L., Robker, R. ... Lane, M. (2015). Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells. Journal of Assisted Reproduction and Genetics, 32, 5, 725-735.
2014 McPherson, N., Fullston, T., Aitken, R. & Lane, M. (2014). Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring. Annals of Nutrition and Metabolism, 64, 3-4, 231-238.
2014 Lane, M., McPherson, N., Fullston, T., Spillane, M., Sandeman, L., Kang, W. & Zander-Fox, D. (2014). Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring. PLoS One, 9, 7, e100832-1-e100832-9.
2014 McPherson, N., Fullston, T., Bakos, H., Setchell, B. & Lane, M. (2014). Obese father's metabolic state, adiposity, and reproductive capacity indicate son's reproductive health. Fertility and Sterility, 101, 3, 865-873.
2013 Fullston, T., Ohlsson Teague, E., Mc Pherson, N., De Blasio, M., Mitchell, M., Corbett, M. ... Lane, M. (2013). Paternal obesity initiates metablic disturbances in two generations of mice with incomplete penetrance to the F₂ generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB Journal, 27, 10, 4226-4243.
2012 Mc Pherson, N., Bakos, H., Fullston, T. & Lane, M. (2012). Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis, 2, 4, 253-263.
2012 Fullston, T., Mc Pherson, N., Owens, J., Mitchell, M., Bakos, H. & Lane, M. (2012). Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice. Human Reproduction, 27, 5, 1391-1400.
2011 Fullston, T., Gabb, B., Callen, D., Ullmann, R., Woollatt, E., Bain, S. ... Gecz, J. (2011). Inherited Balanced Translocation t(9;17)(q33.2;q25.3) Concomitant With a 16p13.1 Duplication in a Patient With Schizophrenia. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156, 2, 204-214.
2011 Mc Pherson, N., Fullston, T., Mitchell, M., Setchell, B. & Lane, M. (2011). SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. Reproduction Fertility and Development, 23, 7, 929-939.
2011 Fullston, T., Mitchell, M., Wakefield, S. & Lane, M. (2011). Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain. Reproduction Fertility and Development, 23, 5, 691-701.
2011 Fullston, T., Finnis, M., Hackett, A., Hodgson, B., Brueton, L., Baynam, G. ... Gecz, J. (2011). Screening and cell-based assessment of mutations in the Aristaless-related homeobox (ARX) gene. Clinical Genetics, 80, 6, 510-522.
2010 Fullston, T., Brueton, L., Willis, T., Philip, S., MacPherson, L., Finnis, M. ... Morton, J. (2010). Ohtahara syndrome in a family with an ARX protein truncation mutation (c.81C>G/p.Y27X). European Journal of Human Genetics, 18, 2, 157-162.
2010 Shoubridge, C., Tan, M., Fullston, T., Cloosterman, D., Coman, D., McGillivray, G. ... Gecz, J. (2010). Mutations in the nuclear localization sequence of the Aristaless related homeobox; Sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division. Pathogenetics, 3, 1, 1-15.
2010 Whibley, A., Plagnol, V., Tarpey, P., Abidi, F., Fullston, T., Choma, M. ... Raymond, F. (2010). Fine-scale survey of X chromosome copy number variants and indels underlying intellectual disability. American Journal of Human Genetics, 87, 2, 173-188.
2010 White, R., Ho, G., Schmidt, S., Scheffer, I., Fischer, A., Yendle, S. ... Christodoulou, J. (2010). Cyclin-dependent kinase-like 5 (CDKL5) mutation screening in Rett syndrome and related disorders. Twin Research and Human Genetics, 13, 2, 168-178.
2010 Shoubridge, C., Fullston, T. & Gecz, J. (2010). ARX spectrum disorders: Making inroads into the molecular pathology. Human Mutation, 31, 8, 889-900.
2009 Demos, M., Fullston, T., Partington, M., Gecz, J. & Gibson, W. (2009). Clinical Study of Two Brothers With a Novel 33 bp Duplication in the ARX Gene. American Journal of Medical Genetics. Part A, 149A, 7, 1482-1486.
2009 Tarpey, P., Smith, R., Pleasance, E., Whibley, A., Edkins, S., Hardy, C. ... Mironenko, T. (2009). A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nature Genetics, 41, 5, 535-543.
2009 Reish, O., Fullston, T., Regev, M., Heyman, E. & Gecz, J. (2009). A novel de novo 27 bp duplication of the ARX gene, resulting from postzygotic mosaicism and leading to three severely affected males in two generations. American Journal of Medical Genetics. Part A, 149A, 8, 1655-1660.
2007 de Brouwer, A., Yntema, H., Kleefstra, T., Lugtenberg, D., Oudakker, A., de Vries, B. ... Fullston, T. (2007). Mutation frequencies of X-linked mental retardation genes in families from the EuroMRX Consortium. Human Mutation, 28, 2, 1-19.
2007 de Brouwer, A., Yntema, H., Kleefstra, T., Lugtenberg, D., Oudakker, A., de Vries, B. ... Fullston, T. (2007). Mutation frequencies of X-linked mental retardation genes in families from the EuroMRX consortium.. Human mutation, 28, 2, 207-208. 2006 Santos-Reboucas, C., Abdalla, C., Fullston, T., Campos Jr, M., Pimentel, M. & Gecz, J. (2006). Lack of FMR3 expression in a male with non-syndromic mental retardation and a microdeletion immediately distal to FRAXE CCG repeat. Neuroscience Letters, 397, 3, 245-248.
Year Citation 2016 Fullston, T., Shehadeh, H., Schjenken, J. E., McPherson, N. O., Robertson, S. A., Zander-Fox, D. & Lane, M. (2016). Paternal Obesity and Programming of Offspring Health. In L. R. Green & R. L. Hester (Eds.), Parental Obesity: Intergenerational Programming and Consequences (pp. 105-131). New York: Springer.
2015 Fullston, T., Wu, L. L., Teede, H. J. & Moran, L. J. (2015). Chapter 11: Obesity and reproductive dysfunction in men and women. In R. R. Watson (Ed.), Handbook of fertility: Nutrition, diet, lifestyle and reproductive health (pp. 119-132). Waltham, MA: Elsevier.
Year Citation 2010 Fullston, T., Mitchell, M., Owens, J., Palmer, N., Bakos, H. & Lane, M. (2010). Paternal Obesity Affects Male Offspring's Health and Sperm Function. 2010 Raymond, L., Whibley, A., Plagnol, V., Tarpey, P., Abidi, F., Fullston, T. ... Stratton, M. (2010). Fine-scale Survey of X Chromosome Copy Number Variants Underlying Intellectual Disability. British Human Genetics Conference. Warwick, RI. 2009 Fullston, T., Mitchell, M., Wakefield, S., Filby, A. & Lane, M. (2009). Micro-Array Analysis of Fetal Mouse Brain Following Induction of Mitochondrial Dysfunction During Pre-Implantation Embryo Development.. 42nd Annual Meeting of the Society-for-the-Study-of-Reproduction. Pittsburgh, PA. 2009 Shoubridge, C., Tan, M., Fullston, T., McGillivray, G., Mancini, G. & Gecz, J. (2009). Unravelling the pathogenesis of the ARX homeobox mutations; role of IPO13. Annual meeting of the American Society of Human Genetics. Honolulu.
Year Citation 2014 Shehadeh, H., Fullston, T., Sandeman, L., Kang, W. & Lane, M. (2014). Paternal obesity impairs the reproductive health and ovarian molecular profile of their female offspring. 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE). Munich, GERMANY. 2011 Owens, J. A., Fullston, T., Mitchell, M., Palmer, N., Bakos, H. & Lane, M. (2011). Diet Induced Paternal Obesity Impairs the Metabolic and Reproductive Health of Two Subsequent Generations.
Awards, Prizes, Travel Grants & Professional Societies
Cumulatively I have been awarded 16 travel grants worth ~$26,600 (AUD) to attend international (9) and national (7) conferences. Additionally I have received $5,600 as prize money for 6 ECR awards. I have been a member of four reproductive biology specific professional societies (SRB, SSR, FSA, SIRT) and local research specific societies (HDA, FFCMH) for 7 years, while maintaining a genetics connection with HGSA membership for 11 years. I have been a member of both the international and ANZ DOHaD societies for 2 years and sit on the inaugural ANZ DOHaD council as the as the ECR Rep. I have also recently joined the founding council of the Epigenetics Consortium of South Australia (EpiCSA Inc). I have been part of the LOC/POCs for 6 national conferences (SRB 2013-14, RRI’s New Frontiers 2016, EpicSA 2016, SIRT 2016, DOHaD-ANZ 2016).
Competitive Grant Funding
*Current funding applications being considered in 2016 submission rounds 1 ARC DECRA, 1 NHMRC CDF1, 1 University of Adelaide Fellowship, 3 NHMRC project grants (AI), 1 Diabetes Australia Research Trust Millennium Grant (AI)* [All of which rely significantly on massively parallel sequencing technologies]
|2016||Current institutional funding – Robinson Research Institute (RRI) – Career Development Fellowship CIA – Fullston T||$100,000|
|2015 - 2017||NHMRC Project Grant ‘Metabolic and molecular basis of embryo signalling’ CIC – Fullston T (CIA – Prof Lane)||$397,000|
|2015 - 2016||Robinson Research Institute – Innovation Seed Funding Program ‘Perturbation of Seminal Fluid Signaling in the Female Reproductive Tract in a Mouse Model of Paternal Obesity’ CIB – Fullston T (CIA Dr Schjenken)||$25,000|
|2014 - 2015||Robinson Research Institute – Innovation Seed Funding Program ‘Human sperm microRNAs are dysregulated by obesity and are potentially biomarkers for ART outcomes’ CIA – Fullston T||$25,000|
|2014 - 2015||Robinson Research Institute – Innovation Seed Funding Program ‘Male obesity changes the methylome of sperm and impairs pregnancy outcomes in humans’ CIB – Fullston T (CIA Dr McPherson)||$20,000|
|2012 - 2015||NHMRC Early Career Fellowship, Australian Biomedical (Peter Doherty) Fellowship
‘The negative transgenerational impacts of paternal obesity are inherited through aberrant methylation and microRNA content of germ cells’ CIA – Fullston T
|2013 - 2013||Diabetes Australia Research Trust General Grant for 2013
‘Paternal obesity and programming of insulin deficiency in offspring -can it be prevented?’ CIB – Fullston T (CIA Dr Ohlsson Teague)
|2012 - 2015||NHMRC Project Grant ‘Paternal dietary signals to offspring: sperm microRNA. You are what your father ate’ AI – Fullston T (CIA Prof Lane)||$656,010|
|2011 - 2013||Bill & Melinda Gates Foundation Phase I ‘Determine the effect of paternal undernutrition on paternal and offspring phenotype’ CIB – Fullston T (CIA Prof Lane)||$100,000 USD|
Teaching, Supervision & Mentoring Roles
To date my HDR supervision includes 9 Honours students (3x primary; 6x co – 8 completions), co-supervised 3 PhD students (1 to completion), formally mentored a Jeffrey Robinson Honours Scholarship holder (2013) and informally mentored a further 4 ECRs, 9 PhD students and 7 Honours students. 7/8 of completed Honours students achieved the highest mark (IA). Completed students currently hold roles as a NHRMC research fellow, research assistants, PhD students, or work in related clinical/biotech fields. As part of the departments PhD annual review panel I assist PhD students to progress through their candidature (2012-15; 6-8 PhD students per year). I have also supervised a total of 6 RAs to date. At the undergraduate level I have been involved in HRHII curriculum design, lectured/tutored HRHIII undergraduate students, supervised 2nd/3rd year Genetics/HRHIII and BHs (Adv) student lab placements (total of 6) and tutored/demonstrated to 1st year Science students. From 2015-2016 I have also been formally mentoring 4 undergraduate BHs (Adv) students.
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