Timothy Sargeant
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
A/Prof Tim Sargeant
BBMedSc. (Human Genetics), Hons. 1st Class, PhD, Victoria University of Wellington (New Zealand)
Please find my socials in the contact tab below, or email me at SAHMRI: Tim.Sargeant@SAHMRI.com
Addressing the Lifespan-Healthspan Gap:
While the 20th century brought remarkable increases in lifespan, reducing the gap between lifespan and healthspan remains a significant challenge. In countries like Australia, the last decade of life is often dominated by age-related diseases. To close this gap, we must address the fundamental drivers of cellular ageing.
Autophagy and lysosomal activity are vital cellular processes that recycle damaged and unwanted material. These mechanisms are crucial for maintaining cellular health during ageing. When they are impaired, biological ageing accelerates, contributing to age-related diseases like atherosclerosis and dementia — leading causes of death in Australia.
A/Prof Tim Sargeant’s team has developed innovative tools to measure autophagy and lysosomal activity in humans and is working on therapies to enhance this recycling machinery. By targeting the biology of ageing itself, their research seeks to improve healthspan and provide transformative solutions to combat age-related diseases at their root.
Scientific Background and Research Focus:
A/Prof Tim Sargeant began his scientific journey with a PhD in neuroscience at Victoria University of Wellington, New Zealand. He subsequently undertook two postdoctoral fellowships at the University of Cambridge (UK), where he gained expertise in molecular and cell biology, focusing on the lysosomal system—the cell’s recycling machinery.
In 2015, Tim was appointed Head of Lysosomal Health in Ageing at the South Australian Health and Medical Research Institute (SAHMRI). His research investigates the role of the lysosomal system in biological ageing, with an emphasis on its ability to clear damaged and unwanted cellular material. By understanding how lysosomal recycling slows cellular ageing, Tim’s work addresses how this process underpins the prevention and treatment of age-related diseases.
- My Research
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Research Overview
Preclinical studies have established that autophagy is vital for healthy ageing, with enhanced autophagy promoting longer healthspans in disease models. However, our understanding of autophagy in humans remains limited. This gap presents a significant challenge for drug development, as pharmaceutical companies cannot readily measure autophagy activity in clinical trials, thereby hindering the translation of autophagy-enhancing drugs and interventions.
To address this critical issue, our research has focused on developing innovative approaches to measure autophagy and lysosomal function in humans. We currently have three active projects:
- Direct measurement of autophagy using human blood.
- Development of biomarkers for autophagy in human biofluids.
- Imaging lysosomal function using positron emission tomography (PET).
This research program has been supported by including but not limited to three NHMRC Ideas Grants and a BrightFocus grant (A/Prof Sargeant as lead investigator).
Direct Measurement of Autophagy Using Human Blood
Overview
The direct measurement of autophagic flux in whole human blood represents our most advanced autophagy assessment technology. This method captures critical data about autophagy within a physiologically intact environment, an essential factor as autophagy is highly sensitive to disruptions.
Methodology
Autophagic flux is measured by detecting LC3B-II through techniques such as western blot, flow cytometry, or ELISA, as illustrated in the accompanying figure.
Milestones and Applications
Since its initial publication in 2021, this method has been adopted in studies by our research group and external collaborators.
Key Publications
- Research from Lysosomal Health in Ageing (SAHMRI):
- Dang et al Preprint
- Singh et al Preprint
- Bensalem et al Publication
- Collaborative research with Lysosomal Health in Ageing (SAHMRI):
- Masedunskas et al Publication
- Research from external groups:
- Mackert et al Publication
- Cooper et al Preprint
Intellectual Property
This technology is protected by patent in the UK (GB2603664B), with patents pending in Australia and the United States.
Development of Biomarkers for Autophagy in Human Biofluids
Addressing a Critical Gap
Our autophagy biomarker programme focuses on discovering and validating blood-borne molecules indicative of intracellular autophagy. While not as mature as our direct autophagy blood test, this initiative is vital for advancing the field.
Strengths and Capabilities
- Mechanistic Insights: Our team of world-class cell biologists investigates the mechanistic links between candidate biomarkers and autophagy, ensuring a deep understanding beyond simple correlations.
- Integrated Approach: Collaborations with SAHMRI's Bioresources and Clinical Trials Platform enable us to validate candidate biomarkers in both preclinical models and human studies.
Impact
Validated biomarkers will enable clinic- or home-friendly autophagy measurements, a key step in translating fundamental ageing science into practical applications.
Imaging Lysosomal Function Using Positron Emission Tomography (PET)
Expanding the Toolkit
While biofluid-based tests are crucial for assessing autophagy, imaging the lysosomal system directly within tissues offers unique insights. This programme aims to develop PET imaging technologies to predict disease emergence, such as the hallmarks of Alzheimer’s disease in the brain.
Current Status
This initiative is in its early stages and is being conducted in collaboration with the Molecular Imaging and Therapy Research Unit (MITRU) at SAHMRI.
Future Vision
Advanced imaging technologies will provide a transformative approach to understanding lysosomal health and predicting disease at the tissue level.
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Appointments
Date Position Institution name 2024 - ongoing Associate Professor (Affiliate) University of Adelaide -
Education
Date Institution name Country Title Victoria University of Wellington New Zealand PhD
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Journals
Year Citation 2025 Singh, S., Carosi, J. M., Dang, L., & Sargeant, T. J. (2025). Autophagy does not always decline with ageing. Nature Cell Biology, 4 pages.
2024 Masedunskas, A., de Ciutiis, I., Hein, L. K., Ge, A., Kong, Y. X., Qi, M., . . . Fontana, L. (2024). Investigating the Impact of Glycogen-Depleting Exercise Combined with Prolonged Fasting on Autophagy and Cellular Health in Humans: A Randomised Controlled Crossover Trial. Nutrients, 16(24), 4297-1-4297-13.
Scopus1 Europe PMC12024 Carosi, J. M., Hein, L. K., Sandow, J. J., Dang, L. V. P., Hattersley, K., Denton, D., . . . Sargeant, T. J. (2024). Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling. Autophagy, 20(4), 863-882.
Scopus3 Europe PMC32024 Singh, S., Bensalem, J., Hein, L. K., Casey, A., Mäkinen, V. P., & Sargeant, T. J. (2024). epHero – a tandem-fluorescent probe to track the fate of apoptotic cells during efferocytosis. Cell Death Discovery, 10(1), 11 pages.
2024 Lloyd-Lewis, B., D’Angelo, M. E., Prowting, N. B., Wiseman, B. E., Sargeant, T. J., & Watson, C. J. (2024). Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells. Journal of Mammary Gland Biology and Neoplasia, 29(1), 15 pages.
Scopus1 Europe PMC12023 Carosi, J. M., & Sargeant, T. J. (2023). Rapamycin and Alzheimer disease: a hypothesis for the effective use of rapamycin for treatment of neurodegenerative disease. Autophagy, 19(8), 2386-2390.
Scopus19 WoS1 Europe PMC152023 Bensalem, J., Hein, L. K., Hassiotis, S., Trim, P. J., Proud, C. G., Heilbronn, L. K., & Sargeant, T. J. (2023). Modifying Dietary Protein Impacts mTOR Signaling and Brain Deposition of Amyloid β in a Knock-In Mouse Model of Alzheimer Disease. Journal of Nutrition, 153(5), 1407-1419.
Scopus4 Europe PMC42023 Schwarz, N., Fernando, S., Chen, Y. -C., Salagaras, T., Rao, S. R., Liyanage, S., . . . Psaltis, P. J. (2023). Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation. The FASEB Journal, 37(4), 1-20.
Scopus26 WoS2 Europe PMC162023 Teong, X. T., Liu, K., Vincent, A. D., Bensalem, J., Liu, B., Hattersley, K. J., . . . Heilbronn, L. K. (2023). Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial. Nature Medicine, 29(4), 963-972.
Scopus56 WoS8 Europe PMC382023 Carosi, J. M., Denton, D., Kumar, S., & Sargeant, T. J. (2023). Receptor Recycling by Retromer. Molecular and Cellular Biology, 43(7), 317-334.
Scopus13 Europe PMC122023 Bensalem, J., Teong, X. T., Hattersley, K. J., Hein, L. K., Fourrier, C., Liu, K., . . . Sargeant, T. J. (2023). Basal autophagic flux measured in blood correlates positively with age in adults at increased risk of type 2 diabetes. Geroscience, 45(6), 3549-3560.
Scopus4 WoS1 Europe PMC52023 Sargeant, T. J., & Fourrier, C. (2023). Human monocyte-derived microglia-like cell models: A review of the benefits, limitations and recommendations. Brain, Behavior, and Immunity, 107, 98-109.
Scopus15 WoS1 Europe PMC132022 Bensalem, J., Heilbronn, L. K., Gore, J. R., Hutchison, A. T., Sargeant, T. J., & Fourrier, C. (2022). The Break-Fast study protocol: a single arm pre-post study to measure the effect of a protein-rich breakfast on autophagic flux in fasting healthy individuals. BMC Nutrition, 8(1), 120-1-120-7.
Scopus12022 Casey, A. E., Liu, W., Hein, L. K., Sargeant, T. J., Pederson, S. M., & Mäkinen, V. P. (2022). Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux. Scientific Reports, 12(1), 12 pages.
Scopus2 Europe PMC22022 Carosi, J. M., Fourrier, C., Bensalem, J., & Sargeant, T. J. (2022). The mTOR–lysosome axis at the centre of ageing. FEBS Open Bio, 12(4), 739-757.
Scopus43 WoS19 Europe PMC322022 Whyte, L. S., Fourrier, C., Hassiotis, S., Lau, A. A., Trim, P. J., Hein, L. K., . . . Sargeant, T. J. (2022). Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease. IBRO Neuroscience Reports, 12, 131-141.
Scopus9 WoS6 Europe PMC112022 Casey, A., Liu, W., Hein, L., Sargeant, T., Pederson, S., & Mäkinen, V. -P. (2022). Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux.
2022 Chaudhary, R., Liu, B., Bensalem, J., Sargeant, T. J., Page, A. J., Wittert, G. A., . . . Heilbronn, L. K. (2022). Intermittent fasting activates markers of autophagy in mouse liver, but not muscle from mouse or humans. Nutrition, 101, 1-7.
Scopus14 WoS2 Europe PMC142022 Vidanapathirana, A. K., Goyne, J. M., Williamson, A. E., Pullen, B. J., Chhay, P., Sandeman, L., . . . Bursill, C. A. (2022). Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor. Biomedicines, 10(8), 1807.
Scopus7 WoS2 Europe PMC42021 Shoubridge, A. P., Fourrier, C., Choo, J. M., Proud, C. G., Sargeant, T. J., & Rogers, G. B. (2021). Gut Microbiome Regulation of Autophagic Flux and Neurodegenerative Disease Risks. Frontiers in Microbiology, 12, 10 pages.
Scopus9 WoS6 Europe PMC92021 Carosi, J. M., Hein, L. K., van den Hurk, M., Adams, R., Milky, B., Singh, S., . . . Sargeant, T. J. (2021). Retromer regulates the lysosomal clearance of MAPT/tau. Autophagy, 17(9), 2217-2237.
Scopus25 WoS20 Europe PMC272021 Fourrier, C., Bryksin, V., Hattersley, K., Hein, L. K., Bensalem, J., & Sargeant, T. J. (2021). Comparison of chloroquine-like molecules for lysosomal inhibition and measurement of autophagic flux in the brain. Biochemical and Biophysical Research Communications, 534, 107-113.
Scopus6 WoS3 Europe PMC62021 Carosi, J. M., Denton, D., Kumar, S., & Sargeant, T. J. (2021). Retromer dysfunction at the nexus of tauopathies. Cell Death and Differentiation, 28(3), 884-889.
Scopus14 WoS9 Europe PMC132021 Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . Aurelian, L. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>. Autophagy, 17(1), 1-382.
Scopus1759 WoS810 Europe PMC14702021 Xie, J., De Poi, S. P., Humphrey, S. J., Hein, L. K., Bruning, J. B., Pan, W., . . . Proud, C. G. (2021). TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling. Cellular and Molecular Life Sciences, 78(8), 4035-4052.
Scopus6 WoS2 Europe PMC32021 Bensalem, J., Fourrier, C., Hein, L. K., Hassiotis, S., Proud, C. G., & Sargeant, T. J. (2021). Inhibiting mTOR activity using AZD2014 increases autophagy in the mouse cerebral cortex. Neuropharmacology, 190, 15 pages.
Scopus8 WoS6 Europe PMC52021 Hattersley, K. J., Carosi, J. M., Hein, L. K., Bensalem, J., & Sargeant, T. J. (2021). PICALM regulates cathepsin D processing and lysosomal function. Biochemical and Biophysical Research Communications, 570, 103-109.
Scopus6 WoS3 Europe PMC42021 Lynn, M. A., Eden, G., Ryan, F. J., Bensalem, J., Wang, X., Blake, S. J., . . . Lynn, D. J. (2021). The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life. Cell Reports, 36(8), 20 pages.
Scopus40 WoS18 Europe PMC332021 Sargeant, T. J., & Bensalem, J. (2021). Human autophagy measurement: an underappreciated barrier to translation. Trends in Molecular Medicine, 27(12), 1091-1094.
Scopus6 WoS5 Europe PMC62021 Carosi, J. M., Nguyen, T. N., Lazarou, M., Kumar, S., & Sargeant, T. J. (2021). ATG8ylation of proteins: a way to cope with cell stress?. The Journal of Cell Biology, 220(11), 1-4.
Scopus12 WoS5 Europe PMC122020 Xie, J., De Poi, S., Humphrey, S., Hein, L., Bruning, J., Pan, W., . . . Proud, C. (2020). TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming.
2020 Bensalem, J., Hattersley, K. J., Hein, L. K., Tong Teong, X., Carosi, J. M., Hassiotis, S., . . . Sargeant, T. J. (2020). Measurement of autophagic flux in humans: an optimized method for blood samples.. Autophagy, 17(10), 3238-3255.
Scopus30 WoS18 Europe PMC312020 Whyte, L. S., Hassiotis, S., Hattersley, K. J., Hemsley, K. M., Hopwood, J. J., Lau, A. A., & Sargeant, T. J. (2020). Lysosomal Dysregulation in the Murine App<sup>NL-G-F/NL-G-F</sup> Model of Alzheimer's Disease. Neuroscience, 429, 143-155.
Scopus13 WoS10 Europe PMC92019 Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., & Bharadwaj, P. (2019). Autophagy modulation as a treatment of amyloid diseases. Molecules, 24(18), 3372-1-3372-20.
Scopus49 WoS43 Europe PMC372019 Cui, Y., Carosi, J. M., Yang, Z., Ariotti, N., Kerr, M. C., Parton, R. G., . . . Teasdale, R. D. (2019). Retromer has a selective function in cargo sorting via endosome transport carriers. Journal of Cell Biology, 218(2), 615-631.
Scopus109 WoS83 Europe PMC962019 Carosi, J. M., & Sargeant, T. J. (2019). Rapamycin and Alzheimer disease: a double-edged sword?. Autophagy, 15(8), 1460-1462.
Scopus77 WoS55 Europe PMC532019 Carosi, J. M., Hattersley, K. J., Cui, Y., Yang, Z., Teasdale, R. D., & Sargeant, T. J. (2019). Subcellular Fractionation of Hela Cells for Lysosome Enrichment Using a Continuous Percoll-Density Gradient. Bio-protocol, 9(18), 9 pages.
Scopus9 WoS5 Europe PMC62018 Hassiotis, S., Manavis, J., Blumbergs, P. C., Hattersley, K. J., Carosi, J. M., Kamei, M., & Sargeant, T. J. (2018). Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus. European Journal of Neuroscience, 47(9), 1043-1053.
Scopus36 WoS25 Europe PMC262018 Lloyd-Lewis, B., Krueger, C. C., Sargeant, T. J., D'Angelo, M. E., Deery, M. J., Feret, R., . . . Watson, C. J. (2018). Stat3-mediated alterations in lysosomal membrane protein composition. Journal of Biological Chemistry, 293(12), 4244-4261.
Scopus24 WoS20 Europe PMC212018 Gao, S., Casey, A. E., Sargeant, T. J., & Makinen, V. P. (2018). Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease. Brain, 141(9), 2711-2720.
Scopus64 WoS46 Europe PMC542017 Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J., & Sargeant, T. J. (2017). Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?. Journal of Neurochemistry, 140(5), 703-717.
Scopus108 WoS95 Europe PMC892017 Hein, L., Apaja, P., Hattersley, K., Grose, R., Xie, J., Proud, C., & Sargeant, T. (2017). A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Biochimica et Biophysica Acta - Molecular Cell Research, 1864(10), 1554-1565.
Scopus19 WoS14 Europe PMC132017 Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Hopwood, J. J., & Sargeant, T. J. (2017). Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer’s disease. Behavioural Brain Research, 336, 177-181.
Scopus58 WoS44 Europe PMC482017 Lloyd-Lewis, B., Sargeant, T. J., Kreuzaler, P. A., Resemann, H. K., Pensa, S., & Watson, C. J. (2017). Analysis of the involuting mouse mammary gland: An in vivo model for cell death. Methods in molecular biology (Clifton, N.J.), 1501, 165-186.
Scopus5 Europe PMC32016 Sargeant, T. J. (2016). Commentary: Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice. Frontiers in Aging Neuroscience, 8(FEB), 3 pages.
Scopus4 WoS3 Europe PMC12015 Wooding, F. B. P., & Sargeant, T. J. (2015). Immunocytochemical Evidence for Golgi Vesicle Involvement in Milk Fat Globule Secretion. Journal of Histochemistry and Cytochemistry, 63(12), 943-951.
Scopus11 WoS8 Europe PMC72014 Sargeant, T. J., Lloyd-Lewis, B., Resemann, H. K., Ramos-Montoya, A., Skepper, J., & Watson, C. J. (2014). Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Nature Cell Biology, 16(11), 1057-1068.
Scopus131 WoS110 Europe PMC1122014 Pensa, S., Lloyd-Lewis, B., Sargeant, T. J., Resemann, H. K., Kahn, C. R., & Watson, C. J. (2014). Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo. FEBS Journal, 281(20), 4557-4567.
Scopus23 WoS19 Europe PMC212014 Campbell, J. J., Botos, L. A., Sargeant, T. J., Davidenko, N., Cameron, R. E., & Watson, C. J. (2014). A 3-D in vitro co-culture model of mammary gland involution. Integrative Biology (United Kingdom), 6(6), 618-626.
Scopus23 WoS23 Europe PMC172013 Al-Lamki, R. S., Lu, W., Wang, J., Yang, J., Sargeant, T. J., Wells, R., . . . Bradley, J. R. (2013). TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-Kit<sup>+</sup> cardiac stem cells in ischemic heart disease. Stem Cells, 31(9), 1881-1892.
Scopus21 WoS19 Europe PMC172012 Sargeant, T. J., Drage, D. J., Wang, S., Apostolakis, A. A., Cox, T. M., & Cachón-González, M. B. (2012). Characterization of Inducible Models of Tay-Sachs and Related Disease. PLoS Genetics, 8(9), 15 pages.
Scopus19 WoS14 Europe PMC112011 Sargeant, T. J., Wang, S., Bradley, J., Smith, N. J. C., Raha, A. A., McNair, R., . . . Cachón-González, M. B. (2011). Adeno-associated virus-mediated expression of β-hexosaminidase prevents neuronal loss in the sandhoff mouse brain. Human Molecular Genetics, 20(22), 4371-4380.
Scopus40 WoS36 Europe PMC322008 Sargeant, T. J., Miller, J. H., & Day, D. J. (2008). Opioidergic regulation of astroglial/neuronal proliferation: Where are we now?. Journal of Neurochemistry, 107(4), 883-897.
Scopus65 WoS55 Europe PMC422008 Sargeant, T. J., Day, D. J., Miller, J. H., & Steel, R. W. J. (2008). Acute in utero morphine exposure slows G<inf>2</inf>/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse. European Journal of Neuroscience, 28(6), 1060-1067.
Scopus27 WoS23 Europe PMC222007 Sargeant, T. J., Day, D. J., Mrkusich, E. M., Foo, D. F., & Miller, J. H. (2007). Mu opioid receptors are expressed on radial glia but not migrating neuroblasts in the late embryonic mouse brain. Brain Research, 1175(1), 28-38.
Scopus24 WoS23 Europe PMC16 -
Preprint
Year Citation 2024 Fourrier, C., Heilbronn, L., Teong, X. T., Gore, J., Sargeant, T., & Bensalem, J. (2024). Protocol for a randomized cross-over study measuring the effect of reduced protein intake on autophagic flux in healthy adults.
DOI2024 Carosi, J., Martin, A., Hein, L., Hassiotis, S., Hattersley, K., Turner, B., . . . Sargeant, T. (2024). Autophagy across tissues of aging mice.
DOI2024 Singh, S., Fourrier, C., Hattersley, K., Hein, L. K., Gore, J., Heilbronn, L. K., . . . Sargeant, T. J. (2024). A high protein meal does not change autophagy in human blood.
DOI2024 Dang, L. V. P., Martin, A., Carosi, J., Gore, J., Singh, S., & Sargeant, T. (2024). Cell-type specific autophagy in human leukocytes.
DOI
We have received funding from the following organisations:
NHMRC
BrightFocus
Diabetes Australia
The Rebecca L Cooper Medical Research Foundation
I teach in the following courses at the University of Adelaide:
Bachelor of Medical Studies (Medical Studies 3) - Ageing 1: Cellular Mechanisms and Ageing 9: Neurological Ageing (2023 - present)
PSYCHIAT 3200 (Fundamentals of Biological Psychiatry) - Biological mechanisms that underpin Alzheimer’s disease (2022 - present)
Biochemistry III (Cancer, Stem Cells and Development) - mTOR, autophagy and cancer (2018- present)
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2025 Principal Supervisor Creating a system to profile the molecular landscape of selective autophagy Doctor of Philosophy Doctorate Full Time Miss Sona Gopinathan 2023 Principal Supervisor Lysosomal function in cellular senescence Doctor of Philosophy Doctorate Full Time Dr Hourieh Tousianshandiz 2022 Co-Supervisor The Evaluation and Validation of Autophagy as a Novel Biomarker of Coronary Artery Disease Doctor of Philosophy Doctorate Part Time Dr Mau Tam Nguyen -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2024 Principal Supervisor Beyond LC3-associated phagocytosis: cross-talk between autophagy and efferocytosis during microglial corpse clearance Doctor of Philosophy Doctorate Full Time Miss Sanjna Singh 2018 - 2023 Co-Supervisor Investigation of the Endolysosomal Network in A Drosophila Model of Alzheimer’s Disease Doctor of Philosophy Doctorate Full Time Miss Sher Li Tan 2015 - 2020 Co-Supervisor The Role of Heterozygous Lysosomal Storage Disorder Alleles as Risk Factors for Dementia Doctor of Philosophy Doctorate Full Time Ms Lauren Sue Whyte
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Committee Memberships
Date Role Committee Institution Country 2025 - ongoing Chair Institutional Biosafety Committee SAHMRI Australia
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