| 2025 |
Kan, W. L., Weekley, C. M., Nero, T. L., Hercus, T. R., Yip, K. H., Tumes, D. J., . . . Parker, M. W. (2025). The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities. Immunological Reviews, 329(1), e13430-1-e13430-25.
DOI Scopus1 WoS3 Europe PMC1 |
| 2024 |
Wang, H., Yip, K. H., Keam, S. P., Vlahos, R., Nichol, K., Wark, P., . . . Tumes, D. J. (2024). Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade. Journal of Allergy and Clinical Immunology, 153(3), 672-683.e6.
DOI Scopus8 WoS8 Europe PMC8 |
| 2024 |
Lim, K., Kan, W. L., Nair, P. C., Kutyna, M., Lopez, A. F., Hercus, T., . . . Thomas, D. (2024). CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting. PLoS One, 19(9), e0310641-1-e0310641-19.
DOI Scopus1 Europe PMC1 |
| 2023 |
Kan, W. L., Dhagat, U., Hercus, T. R., Kaufmann, K. B., Nero, T. L., Zeng, A. G. X., . . . Lopez, A. (2023). Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia. Cancer Discovery, 13(8), 1922-1947.
DOI Scopus9 WoS8 Europe PMC9 |
| 2022 |
Yip, K. H., McKenzie, D., Ramshaw, H. S., Chao, J., McClure, B. J., Raquet, E., . . . Tumes, D. J. (2022). Targeting the human βc Receptor inhibits contact dermatitis in a transgenic mouse model. The Journal of Investigative Dermatology, 142(4), 1103-1113.
DOI Scopus6 WoS6 Europe PMC7 |
| 2022 |
Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., . . . Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death and Disease, 13(137), 1-11.
DOI Scopus28 WoS26 Europe PMC20 |
| 2022 |
Pant, H., Hercus, T. R., Tumes, D. J., Yip, K. H., Parker, M. W., Owczarek, C. M., . . . Huston, D. P. (2022). Translating the biology of β common receptor-engaging cytokines into clinical medicine. Journal of Allergy and Clinical Immunology, 151(2), 324-344.
DOI Scopus14 WoS10 Europe PMC11 |
| 2021 |
Kan, W. L., Cheung Tung Shing, K. S., Nero, T. L., Hercus, T. R., Tvorogov, D., Parker, M. W., & Lopez, A. F. (2021). Messing with βc: a unique receptor with many goals. Seminars in Immunology, 54(101513), 101513-1-101513-14.
DOI Scopus4 WoS4 Europe PMC4 |
| 2018 |
Dhagat, U., Hercus, T. R., Broughton, S. E., Nero, T. L., Cheung Tung Shing, K. S., Barry, E. F., . . . Parker, M. W. (2018). The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. mAbs, 10(7), 1018-1029.
DOI Scopus11 WoS12 Europe PMC9 |
| 2018 |
Tvorogov, D., Thomas, D., Liau, N. P. D., Dottore, M., Barry, E. F., Lathi, M., . . . Lopez, A. F. (2018). Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis. Science Advances, 4(11), 1-12.
DOI Scopus46 WoS47 Europe PMC46 |
| 2018 |
Hercus, T., Kan, W., Broughton, S., Tvorogov, D., Ramshaw, H., Sandow, J., . . . Lopez, A. (2018). Role of the β common (βc) family of cytokines in health and disease. Cold Spring Harbor Perspectives in Biology, 10(6), a028514.
DOI Scopus42 WoS33 Europe PMC31 |
| 2018 |
Broughton, S., Hercus, T., Nero, T., Kan, W., Barry, E., Dottore, M., . . . Parker, M. (2018). A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nature Communications, 9(1), 386-1-386-15.
DOI Scopus33 WoS33 Europe PMC26 |
| 2016 |
Broughton, S. E., Hercus, T. R., Nero, T. L., King-Scott, J., Lopez, A. F., Parker, M. W., . . . Gorman, M. A. (2016). Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. Structure, 24(8), 1271-1281.
DOI Scopus46 WoS45 Europe PMC39 |
| 2016 |
Panousis, C., Dhagat, U., Edwards, K. M., Rayzman, V., Hardy, M. P., Braley, H., . . . Owczarek, C. M. (2016). CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. mAbs, 8(3), 436-453.
DOI Scopus40 WoS34 Europe PMC31 |
| 2016 |
Gargett, T., Christo, S. N., Hercus, T. R., Abbas, N., Singhal, N., Lopez, A. F., & Brown, M. P. (2016). GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 5(12), 12 pages.
DOI Scopus39 WoS32 Europe PMC28 |
| 2015 |
Broughton, S. E., Nero, T. L., Dhagat, U., Kan, W. L., Hercus, T. R., Tvorogov, D., . . . Parker, M. W. (2015). The βc receptor family - Structural insights and their functional implications. Cytokine, 74(2), 247-258.
DOI Scopus69 WoS62 Europe PMC55 |
| 2014 |
Hercus, T., Broughton, S., Hardy, M., Nero, T., Wilson, N., Parker, M., & Lopez, A. (2014). Unexpected mechanisms of action for a cytokine receptor-blocking antibody.. Molecular & cellular oncology, 1(4), e969129.
DOI Scopus1 WoS1 Europe PMC1 |
| 2014 |
Broughton, S., Hercus, T., Hardy, M., McClure, B., Nero, T., Dottore, M., . . . Lopez, A. (2014). Dual mechanism of Interleukin-3 receptor blockade by an anti-cancer antibody. Cell Reports, 8(2), 410-419.
DOI Scopus53 WoS47 Europe PMC40 |
| 2013 |
Hercus, T., Dhagat, U., Kan, W., Broughton, S., Nero, T., Perugini, M., . . . Lopez, A. (2013). Signalling by the βc family of cytokines. Cytokine & Growth Factor Reviews, 24(3), 189-201.
DOI Scopus87 WoS79 Europe PMC73 |
| 2012 |
Broughton, S., Dhagat, U., Hercus, T., Nero, T., Grimbaldeston, M., Bonder, C., . . . Parker, M. (2012). The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunological Reviews, 250(1), 277-302.
DOI Scopus211 WoS194 Europe PMC179 |
| 2012 |
Hercus, T., Broughton, S., Ekert, P., Ramshaw, H., Perugini, M., Grimbaldeston, M., . . . Lopez, A. (2012). The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors, 30(2), 63-75.
DOI Scopus63 WoS59 Europe PMC54 |
| 2010 |
Perugini, M., Brown, A., Salerno, D., Booker, G., Stojkoski, C., Hercus, T., . . . D'Andrea, R. (2010). Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit. Blood, 115(16), 3346-3353.
DOI Scopus59 WoS52 Europe PMC45 |
