Dr Tim Barnes

Research Interests

Artificial Intelligence Assessment, development and evaluation of curriculum Higher Education Inorganic materials (incl. nanomaterials) Learning, motivation and emotion Nanomaterials Nanomedicine Online learning Pharmacology and Pharmaceutical Sciences Reinforcement learning Student Engagement Teaching and curriculum Teaching and instruction technologies

Dr Tim Barnes

Program Director: Pharmaceutical Science

School of Pharmacy and Biomedical Science

College of Health

Welcome to my homepage! I am a Physical Chemist by training, I teach drug formulation science into the Pharmacy and Pharmaeutical Science Programs, nanotechnology in the Bachelor of Science Program. I am the author of more than 40 refereed international journal articles, text book chapters and conference papers, as well as more than 30 major reports to industry. I have supervised 8 PhD students and more than 20 honours and research project students.
I am actively involved in the Prestidge Research Group, which is focussed on Nanomedicine and Biopharmaceutical Engineering - I am interested in developing novel therapeutic delivery strategies for both small molecule and protein pharmaceuticals. I have also consulted for numerous Pharmaceutical companies both within Australia and internationally.

Novel drug delivery systems,Nanotechnology,Influence of Protein damage on protein-protein/protein-surface interactions

Date Type Title Institution Name Country Amount
2018 Nomination Citation for Outstanding Contributions to Student Learning Australian Awards for University Teaching Australia -
2017 Award Citation for Outstanding Contributions to Student Learning University of South Australia Australia 1500
2010 Nomination Student Nominated Excellent Educator Award University of South Australia Australia -

Date Institution name Country Title
2020 - 2022 University of South Australia Australia Graduate Certificate
2002 - 2002 University of Adelaide Australia Graduate Diploma
1998 - 2023 University of South Australia Australia Doctor of Philosophy
1997 - 1997 University of South Australia Australia Bachelor of Applied Science (Honours)
1994 - 1996 University of South Australia Australia Bachelor of Applied Science

Year Citation
2025 Ahsan, A., Barnes, T. J., Thomas, N., Subramaniam, S., & Prestidge, C. A. (2025). Lipid-based nanocarriers for enhanced gentamicin delivery: a comparative study of liquid crystal nanoparticles and liposomes against Escherichia coli biofilms. Drug Delivery And Translational Research, online(11), 1-22.
DOI
2024 Ahsan, A., Thomas, N., Barnes, T. J., Subramaniam, S., Loh, T. C., Joyce, P., & Prestidge, C. A. (2024). Lipid nanocarriers-enabled delivery of antibiotics and antimicrobial adjuvants to overcome bacterial biofilms. Pharmaceutics, 16(3, article no. 396), 1-46.
DOI
2023 Hassan, M. M., Romana, B., Mao, G., Kumar, N., Sonvico, F., Thordarson, P., . . . Prestidge, C. A. (2023). Liposome-Micelle-Hybrid (LMH) carriers for controlled co-delivery of 5-FU and paclitaxel as chemotherapeutics. Pharmaceutics, 15(7, article no. 1886), 1-17.
DOI
2023 Awad, M., Barnes, T. J., & Prestidge, C. A. (2023). Lyophilized Lipid Liquid Crystalline Nanoparticles as an Antimicrobial Delivery System. Antibiotics, 12(9), 1405.
DOI Scopus3
2023 Awad, M., Kopecki, Z., Barnes, T. J., Wignall, A., Joyce, P., Thomas, N., & Prestidge, C. A. (2023). Lipid Liquid Crystal Nanoparticles: Promising Photosensitizer Carriers for the Treatment of Infected Cutaneous Wounds. Pharmaceutics, 15(2), 1-18.
DOI Scopus6 WoS5 Europe PMC3
2023 Bremmell, K. E., Barnes, T. J., Hughes, B. P., Birbeck, D. J., Johnson, J., & Suppiah, V. (2023). Design and implementation of a program wide pharmaceutical compounding curriculum using the scaffold learning approach. CURRENTS IN PHARMACY TEACHING AND LEARNING, 15(2), 178-185.
DOI Scopus1 WoS1
2022 Awad, M., Barnes, T. J., Thomas, N., Joyce, P., & Prestidge, C. A. (2022). Gallium Protoporphyrin Liquid Crystalline Lipid Nanoparticles: A Third-Generation Photosensitizer against Pseudomonas aeruginosa Biofilms. Pharmaceutics, 14(10), 2124.
DOI Scopus13
2022 Awad, M., Barnes, T. J., Joyce, P., Thomas, N., & Prestidge, C. A. (2022). Liquid crystalline lipid nanoparticle promotes the photodynamic activity of gallium protoporphyrin against S. aureus biofilms. Journal of Photochemistry and Photobiology B: Biology, 232(112474), 112474.
DOI Scopus17 Europe PMC9
2022 Awad, M., Thomas, N., Barnes, T. J., & Prestidge, C. A. (2022). Nanomaterials enabling clinical translation of antimicrobial photodynamic therapy. Journal of Controlled Release, 346, 300-316.
DOI Scopus59 Europe PMC35
2022 Wright, L., Barnes, T. J., Joyce, P., & Prestidge, C. A. (2022). Optimisation of a High-Throughput Model for Mucus Permeation and Nanoparticle Discrimination Using Biosimilar Mucus. Pharmaceutics, 14(12), 2659.
DOI Scopus11 WoS10 Europe PMC5
2021 Wright, L., Joyce, P., Barnes, T. J., Lundmark, R., Bergström, C. A. S., Hubert, M., & Prestidge, C. A. (2021). A Comparison of Chitosan, Mesoporous Silica and Poly(lactic-co-glycolic) Acid Nanocarriers for Optimising Intestinal Uptake of Oral Protein Therapeutics. Journal of Pharmaceutical Sciences, 110(1), 217-227.
DOI Scopus9 WoS11 Europe PMC7
2021 Wright, L., Joyce, P., Barnes, T. J., & Prestidge, C. A. (2021). Mimicking the Gastrointestinal Mucus Barrier: Laboratory-Based Approaches to Facilitate an Enhanced Understanding of Mucus Permeation. ACS Biomaterials Science & Engineering, 9(6), 19 pages.
DOI Scopus23 WoS24 Europe PMC14
2020 Wright, L., Barnes, T. J., & Prestidge, C. A. (2020). Oral delivery of protein-based therapeutics: Gastroprotective strategies, physiological barriers and in vitro permeability prediction. International Journal of Pharmaceutics, 585(article no. 119488), 119488-1-119488-17.
DOI Scopus36 WoS31 Europe PMC23
2020 Romana, B., Hassan, M. M., Sonvico, F., Garrastazu Pereira, G., Mason, A. F., Thordarson, P., . . . Prestidge, C. A. (2020). A liposome-micelle-hybrid (LMH) oral delivery system for poorly water-soluble drugs: enhancing solubilisation and intestinal transport. European Journal of Pharmaceutics and Biopharmaceutics, 154, 338-347.
DOI
2019 Wang, F., Barnes, T. J., & Prestidge, C. A. (2019). Controlling and predicting the dissolution kinetics of thermally oxidised mesoporous silicon particles: towards improved drug delivery. Pharmaceutics, 11(12, article no. 634), 1-15.
DOI
2016 Liau, J. J., Prestidge, C. A., Hook, S., & Barnes, T. J. (2016). Development of a multi-compartmental oral vaccine delivery system. Drug delivery letters, 6(1), 57-62.
DOI
2016 Chang, P. K., Prestidge, C. A., Barnes, T. J., & Bremmell, K. E. (2016). Impact of PEGylation and non-ionic surfactants on the physical stability of the therapeutic protein filgrastim (G-CSF). RSC advances, 6(82), 78970-78978.
DOI
2016 Joyce, P., Barnes, T. J., Boyd, B. J., & Prestidge, C. A. (2016). Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products. RSC advances, 6(82), 78385-78395.
DOI
2015 Bhatt, A. B., Barnes, T. J., & Prestidge, C. A. (2015). Silica nanoparticle stabilization of liquid crystalline lipid dispersions: impact on enzymatic digestion and drug solubilization. Current drug delivery, 12(1), 47-55.
DOI
2015 Barnes, T. J., & Prestidge, C. A. (2015). Recent advances in porous silicon-based therapeutic delivery. Therapeutic Delivery, 6(2), 97-100.
DOI
2015 Liau, J. J., Hook, S., Prestidge, C. A., & Barnes, T. J. (2015). A lipid based multi-compartmental system: Liposomes-in-double emulsion for oral vaccine delivery. European Journal of Pharmaceutics and Biopharmaceutics, 97, 15-21.
DOI
2014 Roy, B., Panda, A. K., Parimi, S., Ametov, I., Barnes, T., & Prestidge, C. A. (2014). Physio-chemical studies on the interaction of dendrimers with lipid bilayers. 1. effect of dendrimer generation and liposome surface charge.. Journal of oleo science, 63(11), 1185-1193.
DOI
2013 Wang, F., Barnes, T. J., & Prestidge, C. A. (2013). Celecoxib confinement within mesoporous silicon for enhanced oral bioavailability. Mesoporous Biomaterials, 1(1), 1-16.
DOI
2013 Barnes, T. J., Jarvis, K. L., & Prestidge, C. A. (2013). Recent advances in porous silicon technology for drug delivery. Therapeutic delivery, 4(7), 811-823.
DOI
2012 Jarvis, K. L., Barnes, T. J., & Prestidge, C. A. (2012). Surface chemistry of porous silicon and implications for drug encapsulation and delivery applications. Advances in colloid and interface science, 175, 25-38.
DOI
2012 Simovic, S., Barnes, T. J., Tan, A., & Prestidge, C. A. (2012). Assembling nanoparticle coatings to improve the drug delivery performance of lipid based colloids. Nanoscale, 4(4), 1220-1230.
DOI
2012 Dong, Y. D., Larson, I., Barnes, T. J., Prestidge, C. A., Allen, S., Chen, X., . . . Boyd, B. J. (2012). Understanding the interfacial properties of nanostructured liquid crystalline materials for surface-specific delivery applications. Langmuir, 28(37), 13485-13495.
DOI Scopus36 Europe PMC16
2011 Dong, Y. D., Larson, I., Barnes, T. J., Prestidge, C. A., & Boyd, B. J. (2011). Adsorption of nonlamellar nanostructured liquid-crystalline particles to biorelevant surfaces for improved delivery of bioactive compounds. ACS applied materials and interfaces, 3(5), 1771-1780.
DOI
2011 Jarvis, K. L., Barnes, T. J., & Prestidge, C. A. (2011). Surface chemical modification to control molecular interactions with porous silicon. Journal of colloid and interface science, 363(1), 327-333.
DOI
2011 Barnes, T. J., Kempson, I. M., & Prestidge, C. A. (2011). Surface analysis for compositional, chemical and structural imaging in pharmaceutics with mass spectrometry: A ToF-SIMS perspective. International Journal of Pharmaceutics, 417(1-2), 61-69.
DOI Scopus49 WoS49 Europe PMC19
2010 Kempson, I. M., Barnes, T. J., & Prestidge, C. A. (2010). Use of TOF-SIMS to Study Adsorption and Loading Behavior of Methylene Blue and Papain in a Nano-Porous Silicon Layer. Journal of the American Society for Mass Spectrometry, 21(2), 254-260.
DOI Scopus28 WoS23 Europe PMC10
2010 Kempson, I. M., Martin, A. L., Denman, J. A., French, P. W., Prestidge, C. A., & Barnes, T. J. (2010). Detecting the presence of denatured human serum albumin in an adsorbed protein monolayer using TOF-SIMS. Langmuir, 26(14), 12075-12080.
DOI Scopus33 WoS33 Europe PMC23
2010 Ngo, S., & Barnes, T. (2010). Is there variability in drug release and physical characteristics of amiodarone chloride from different commercially available tablets? Possible therapeutic implications. The International Journal of Pharmacy Practice, 18(4), 245-248.
DOI Scopus5 Europe PMC2
2010 Parimi, S., Barnes, T., Callen, D., & Prestidge, C. (2010). Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers. Biomacromolecules, 11(2), 382-389.
DOI Scopus47 WoS46 Europe PMC27
2010 Vellore Janarthanan, M., Barnes, T. J., & Prestidge, C. A. (2010). Silica nanoparticle coated liposomes : a new type of hybrid nanocapsule for proteins. International journal of pharmaceutics, 392(1/2), 285-293.
DOI
2010 Wang, F. F., He, H., Barnes, T. J., Barnett, C., & Prestidge, C. A. (2010). Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs. Molecular pharmaceutics, 7(1), 227-236.
DOI
2010 Jarvis, K., Barnes, T. J., & Prestidge, C. A. (2010). Thermal oxidation for controlling protein interactions with porous silicon. Langmuir, 26(17), 14316-14322.
DOI
2009 Er, Y., Barnes, T. J., Fornasiero, D., & Prestidge, C. A. (2009). The encapsulation and release of guanosine from PEGylated liposomes. Journal of liposome research, 19(1), 29-36.
DOI
2008 Parimi, S., Barnes, T. J., & Prestidge, C. A. (2008). PAMAM dendrimer interactions with supported lipid bilayers : a kinetic and mechanistic investigation. Langmuir, 24(23), 13532-13539.
DOI
2008 Britcher, L. G., Barnes, T. J., Griesser, H. J., & Prestidge, C. A. (2008). PEGylation of Porous Silicon Using Click Chemistry. Langmuir, 24(15), 7625-7627.
DOI
2008 Barnes, T. J., Jarvis, K., & Prestidge, C. A. (2008). Aqueous and Thermal Oxidation of Porous Silicon Microparticles: Implications on Molecular Interactions. Langmuir, 24(24), 14222-14226.
DOI
2008 Barnes, T. J., Ametov, I., & Prestidge, C. A. (2008). Dendrimer adsorption on charged particulate surfaces. Asia-Pacific Journal of Chemical Engineering, 3(1), 13-17.
DOI
2008 Barnes, T. J., Ametov, I., & Prestidge, C. A. (2008). Naphthalene sulphonate functionalized dendrimers at the solid-liquid interface: influence of core type, ionic strength and competitive ionic adsorbates. Langmuir, 24(21), 12398-12404.
DOI
2008 Jarvis, K., Barnes, T., Badalyan, A., Pendleton, P., & Prestidge, C. (2008). Impact of thermal oxidation on the adsorptive properties and structure of porous silicon particles. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces, 112(26), 9717-9722.
DOI Scopus34 WoS29
2008 Prestidge, C. A., Barnes, T. J., MierczynsKa-Vasilev, A., Kempson, I., Peddie, F., & Barnett, C. (2008). Peptide and protein loading into porous silicon wafers. Physica Status Solidi A Applications and Materials Science, 205(2), 311-315.
DOI Scopus42 WoS39
2007 Prestidge, C. A., Barnes, T. J., & Skinner, W. M. (2007). Time-of-flight secondary-ion mass spectrometry for the surface characterization of solid-state pharmaceuticals. Journal of pharmacy and pharmacology, 59(2), 251-259.
DOI Scopus22 WoS18 Europe PMC8
2007 Prestidge, C. A., Barnes, T. J., Mierczynska Vasilev, A., Skinner, W. M., Peddie, F., & Barnett, C. (2007). Loading and release of a model protein from porous silicon powders. Physica status solidi. A : applications and materials science, 204(10), 3361-3366.
DOI Scopus42 WoS35
2007 Prestidge, C. A., Barnes, T. J., Lau, C. H., Barnett, C., Loni, A., & Canham, L. (2007). Mesoporous silicon: a platform for the delivery of therapeutics. Expert Opinion on Drug Delivery, 4(2), 101-110.
DOI
2004 Prestidge, C. A., Barnes, T. J., & Simovic, S. (2004). Polymer and particle adsorption at the PDMS droplet-water interface. Advances in colloid and interface science, 108-109, 105-118.
DOI
2000 Prestidge, C. A., & Barnes, T. J. (2000). PEO-PPO-PEO block copolymers at the emulsion droplet-water interface. Langmuir, 16(9), 4116-4121.
DOI

Year Citation
2007 Jarvis, K., Barnes, T. J., & Prestidge, C. A. (2007). The influence of thermal oxidation on the surface chemical and adsorbent properties of porous silicon. In 35th Australasian Chemical Engineering Conference (2007 Chemeca): Conference Proceedings. Australia: Engineers Australia.
2006 Barnes, T. J., Prestidge, C. A., Mierczynska Vasilev, A., Kempson, I. M., & Peddie, F. (2006). Peptide and protein loading into porous silicon wafers. In Chemeca 2006 : knowledge and innovation : conference proceedings (pp. 1019-1023). Auckland, N.Z.: Centre for Continuing Education.
2006 Barnes, T. J., Ametov, I., & Prestidge, C. A. (2006). Dendrimer assembly in solution and at interfaces. In Proceedings of the 2006 International Conference on Nanoscience and Nanotechnology. Piscataway, NJ: IEEE.
DOI
2006 Ametov, I., Barnes, T. J., & Prestidge, C. A. (2006). Atomic force microscopy and dynamic light scattering studies of dendrimer aggregation. In Chemeca 2006 : knowledge and innovation : conference proceedings. Auckland, N.Z.: Centre for Continuing Education.
2006 Jarvis, K., Barnes, T. J., Prestidge, C. A., Badalyan, A., & Pendleton, P. (2006). Porous silicon : a nanostructured delivery system. In Proceedings of the 2006 International Conference on Nanoscience and Nanotechnology (pp. 536-539). Piscataway, NJ: IEEE.
DOI Scopus2 WoS1
2005 Barnes, T. J., Er, Y., Tan, A., Prestidge, C. A., & Evans, A. M. (2005). Colloidal stability of lecithin liposomes. In Smart Solutions Doing More with Less, Chemeca 2005: Conference Proceedings. Australia: Institution of Engineers, IChemE, SCENZ and RACI, with University of Queensland.
2005 Barnes, T. J., Er, Y., Prestidge, C. A., & Fornasiero, D. (2005). Role of PEG-lipids on the controlled release of a model hydrophilic drug from liposomes. In Smart Solutions Doing More with Less, Chemeca 2005: Conference Proceedings. Australia: Institution of Engineers, IChemE, SCENZ and RACI, with University of Queensland.
2003 Ametov, I., Prestidge, C. A., & Barnes, T. J. (2003). Rheological investigations of emulsion stability. In CHEMECA 2003: Products and Processes for the 21st Century. Australia.
2000 Prestidge, C. A., & Barnes, T. J. (2000). The deformability and interaction of PDMS emulsion droplets in water. In 10th International Conference on Colloid and Interface Science.

Date Role Board name Institution name Country
2014 - ongoing Director Australian Controlled Release Society Australian Controlled Release Society Pty Ltd Australia
2014 - ongoing Treasurer Australian Controlled Release Society Australian Controlled Release Society Pty Ltd Australia

Date Role Committee Institution Country
2022 - ongoing Member Research Degree Coordinator Panel University of South Australia Australia
2018 - 2023 Member Teaching Innovation and Research Team (for Learning) - TIRTL University of South Australia Australia
2012 - ongoing Board Member RACI Pharmaceutical Science Special Interest Group (SA) Royal Australian Chemical Institute Australia
2011 - 2012 Member Division of Health Sciences Level A-B Promotion Committee University of South Australia Australia
2007 - 2009 Member Pharmaceutical Science Degree Development Committee University of South Australia Australia

Date Role Membership Country
2023 - ongoing Member Australasian Pharmaceutical Science Association -
1999 - ongoing Member Royal Australian Chemistry Institute -

Date Title Engagement Type Institution Country
2018 - ongoing Nanomedicine: What's the BIG deal about such small Science? Public Community Engagement Prince Alfred College Australia

Date Event Name Event Type Institution Country
2025 - 2025 Drug Delivery Australia 2025 Conference University of New South Wales Australia
2025 - 2025 The International Conferences on Life Long Learning in Pharmacy Conference University of Sydney Australia

Date Engagement Type Partner Name
2016 - 2019 Research Contract BTG Holdings
2013 - 2015 Research Contract vivoPharm
2006 - 2009 Research Contract Hospira Adelaide Pty Ltd
2006 - 2006 Research Contract Metabolic Pharmaceuticals
2006 - 2015 Research Contract pSiMedica Ltd
2006 - ongoing Research Contract Mayne Pharma

Date Title Type Institution Country
2024 - ongoing External reviewer for the pharmaceutical science components of our BPharm and the new BPharmSc degree Peer Review University of Otago New Zealand
2023 - ongoing RACI Accreditation Panel Peer Review Royal Australian Chemical Institute Australia

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