Dr Stephen Fitter
NHMRC Grant-Funded Researcher (B)
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Research
I am currently involved in a number of projects including (1) examining the role of the mTORC1 complex in skeletal development and mesenchymal stem cell lineage determination (2) projects examining the role of osteoblastic-mTORC1 in B-cell development and glucose homeostasis (3) a project examining the role of bone marrow stroma in the pathology of pediatric acute lymphoblastic leukemia.
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Appointments
Date Position Institution name 2013 - ongoing Research Fellow Level B University of Adelaide 2006 - 2013 Post doctoral research scientist Myeloma Research Program, Bone and Cancer Laboratories, Hanson Institute and Division of Haematology, Institute of Medical and Veterinary Science -
Education
Date Institution name Country Title 2006 Flinders University, Adelaide Australia Doctor of Philosophy 1996 University of Adelaide, Adelaide Australia Master Qualifying 1990 Flinders University, Adelaide Australia Bachelor of Science
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Journals
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Conference Papers
Year Citation 2018 Tangseefa, P., Martin, S. K., Wilczek, V., Baldock, P., Proud, C. G., Fitter, S., & Zannettino, A. C. W. (2018). Metabolic and reproductive abnormalities in mice with impaired skeletal-mTORC1 function mirror a dietary restriction phenotype. In CLINICAL ENDOCRINOLOGY Vol. 89 (pp. 19). Perth, AUSTRALIA: WILEY. 2016 Asari, K., Heatley, S. L., Sadras, T., Leclercq, T. M., Fitter, S., Kok, C. H., . . . White, D. L. (2016). <i>In Vitro</i> Modeling of Ph-like ALL Fusions Identifies Novel Kinase-Domain Mutations As Mode of TKI-Resistance Implications for Targeted Therapy. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
DOI2008 Vandyke, K., Dewar, A., Diamond, P., Fitter, S., Farrugia, A. N., To, L. B., . . . Zannettino, A. C. W. (2008). Dasatinib (Sprycel™) Inhibits Oteoclast Activity <i>in Vitro</i> and <i>in Vivo</i> Via a C-Fms-Dependent and C-Src-Independent Mechanism. In BLOOD Vol. 112 (pp. 1102-1103). San Francisco, CA: AMER SOC HEMATOLOGY. -
Conference Items
Year Citation 2018 Asari, K., Leclercq, T., Srihari, S., Fitter, S., Yeung, D., Hughes, T., . . . White, D. L. (2018). in vitro modelling of Ph-like ALL uncovers novel genomic alterations associated with TKI-resistance as a consequence of targeted therapy. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland. 2017 Asari, K., Sadras, T., Srihari, S., Fitter, S., An, J., Zannettino, A. C., . . . White, D. L. (2017). in vitro Modelling of Ph-like ALL Fusions Uncovers Novel Kinase-domain Mutations as a Mode of TKI-resistance and Potential Consequence of Targeted TKI Therapy. Poster session presented at the meeting of ANZCHOG. 2016 Asari, K., Heatley, S., Leclercq, T., Fitter, S., Zannettino, A., Hughes, T., & White, D. L. (2016). In vitro Modelling of Therapeutic Resistance to Elucidate Mechanisms of TKI-Resistant High-Risk ALL. Poster session presented at the meeting of .. Noosa, QLD. 2016 Asari, K., Heatley, S., Leclercq, T., Fitter, S., Kok, C. H., Zannettino, A., . . . White, D. L. (2016). Investigating Modes of Therapeutic Resistance via In Vitro Modelling of TKI-resistant High-Risk Philadelphia-chromosome-positive and Philadelphia-chromosome-like Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA.
Grants Awarded
2021 |
Investigators: Zannettino, ACW and Fitter S. Investigator status: Chief Investigator B Title: Development of a novel glucose lowering medication targeting mTORC1 in osteoblasts. |
$649,347.00 |
2014 |
Investigators: Fitter S, Zannettino, ACW, Gronthos S. Investigator status: Co-investigator Title: An improved technology for isolating human adult stem cells for regenerative therapies. Fund: Commercial Accelerator Fund; Adelaide Research and Innovation |
$100,000 |
2011 |
Investigators: Zannettino, ACW, Gronthos, Fitter S. Investigator status: Chief Investigator C Title: Defining a role for rictor and raptor in mesenchymal cell fate determination Fund: National Health and Medical Research Foundation |
$650,000 |
2010 |
Investigators: Fitter S., Matin S, D’Andrea R and Zannettino, ACW. Investigator status: Co-investigator Title: Defining a role for rictor and raptor in mesenchymal cell fate determination Fund: CRC Centre for Stem Cell Research, University of Adelaide |
$75,000 |
2009 |
Investigators: Fitter S., To, LB. and Zannettino, ACW. Investigator status: Co-investigator Title: Defining a role for rictor and raptor in mesenchymal cell fate determination Fund: Contributing Haematologists Cnommittee (CHC), Division of Haematology, IMVS |
$20,000 |
2008 |
Investigators: Fitter S., Evdokiou A., Hughes TP., and Zannettino, ACW. Investigator status: Co-investigator Title: TKI inhibitors as modulators of leukemia induced bone loss Fund: Leukemia and Lymphoma Society Translational research program |
$600,000 |
2006 |
Investigators: Fitter, S., To, LB. and Zannettino, ACW. Investigator status: Co-investigator Title: Development of a therapeutic aptamer that antagonises SDF-1a (CXCL12) binding to CXCR4. Fund: Contributing Haematologists Committee (CHC), Division of Haematology, IMVS |
$27,000 |
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Investigating mechanisms of relapse in high-risk paediatric pre-B-cell acute lymphoblastic leukaemia Doctor of Philosophy Doctorate Full Time Mr Caleb Ben Lill 2022 Principal Supervisor Genetic and biochemical characterisation of the SIK3 mutation, R393H: A causal mutation that helps define a new family of human monogenetic disorders Doctor of Philosophy Doctorate Full Time Eliana Gloria Stanziano 2021 Principal Supervisor Interventions and Novel Treatments for Obesity-associated Pathologies Doctor of Philosophy Doctorate Full Time Miss Alanah Loretta Bradey -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2020 Co-Supervisor The Role of Osteoblast-mTORC1 in the Regulation of Glucose Metabolism Doctor of Philosophy Doctorate Full Time Miss Pawanrat Tangseefa 2010 - 2018 Co-Supervisor The Role of mTORC1 in Mesenchymal Stem Cell Fate Determination, Osteoblast Differentiation and Skeletal Development Doctor of Philosophy Doctorate Part Time Ms Mary Patricia Matthews 2007 - 2010 Co-Supervisor The Effects of Tyrosine Kinase Inhibition on Bone Remodelling Doctor of Philosophy Doctorate Full Time Dr Kate Vandyke
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