Simon Pyke

EPrf Simon Pyke

School of Physics, Chemistry and Earth Sciences

College of Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Professor Simon Pyke has been at the University of Adelaide since 1992 (first appointed as Lecturer). Since appointment, his career has increasingly become focused on Learning & Teaching (he has held a variety of leadership roles since 2007). In 2015 he was appointed Deputy Dean (Learning & Teaching) in the Faculty of Sciences and transitioned to an 'Education Specialist' role in recognition of his expertise as a leader in learning & teaching. He then served as Deputy Dean (International) in the Faculty of Sciences (2019-2022). On retiring in 2024 he was conferred the title of Emeritus Professor.

My research interests lie in two fields:

  1. Organic Chemistry

    - medicinal chemistry of small bioactive molecules and their interactions with protein targets;

    - bio-organic chemistry & molecular toxicology of highly reactive aldehydes;

    - application of NMR spectroscopy for the determination of molecular structure,

    - conformation and dynamics of small organic molecules and protein-small molecule complexes;

    - natural products chemistry;
  2. Science Education

    - curriculum design, construction and assessment;

    - facilitating development of skills (discipline related & generic);

    - classroom practice;

    - student attitudes to learning.

Date Position Institution name
2024 - ongoing Emeritus Professor University of Adelaide
2019 - 2022 Deputy Dean (International), Faculty of Sciences University of Adelaide
2015 - 2018 Deputy Dean (Learning & Teaching) University of Adelaide
2014 - 2024 Professor University of Adelaide
2011 - 2012 Acting Director, Centre for Learning & Professional Development University of Adelaide
2009 - 2013 Associate Professor University of Adelaide
2007 - 2014 Associate Dean (Learning & Quality) University of Adelaide
1998 - 2008 Senior Lecturer University of Adelaide
1992 - 1997 Lecturer University of Adelaide

Date Type Title Institution Name Country Amount
2016 Fellowship Fellow, Royal Society of Chemistry Royal Society of Chemistry United Kingdom -
2014 Fellowship Fellow, Royal Australian Chemical Institute Royal Australian Chemical Institute Australia -
2014 Teaching Award Fensham Medal for Outstanding Contributions to Chemical Education Royal Australian Chemical Institute Australia -
2010 Teaching Award Stephen Cole the Elder Award for Excellence in Teaching University of Adelaide Australia -
2008 Teaching Award Citation for Outstanding Contribution to Student Learning Australian Learning & Teaching Council Australia -
2007 Teaching Award D. R. Stranks Medal for Excellence in Chemistry Education Royal Australian Chemical Institute (S.A. Branch) Australia -
2001 Teaching Award Stephen Cole the Elder Award for Excellence in Teaching University of Adelaide Australia -

Date Institution name Country Title
1985 - 1988 University of Sydney, Sydney Australia PhD
1980 - 1984 University of Sydney, Sydney Australia Bachelor of Science (Honours)

Date Title Institution Country
1989 - 1992 Postdoctoral Fellow University of East Anglia, Norwich United Kingdom

Date Title Institution name Country
— Chartered Chemist Royal Australian Chemical Institute -
— Chartered Chemist Royal Society of Chemistry -

Year Citation
2023 Schultz, M., Southam, D. C., Buntine, M., Colthorpe, K., Howitt, S., Johnson, E., . . . Yucel, R. (2023). 'Transformative': The threshold learning outcomes for science. Australian Journal of Chemistry, 76(12), 908-920.
DOI Scopus3 WoS3
2020 Buntine, M. A., Silva, K. B. D., Kable, S. H., Lim, K. F., Pyke, S. M., Read, J. R., . . . Yeung, A. (2020). Perceptions and Misconceptions about the Undergraduate Laboratory from Chemistry, Physics and Biology Academics. International Journal of Innovation in Science and Mathematics Education, 28(4), 1-15.
DOI Scopus4
2019 Sarkar, M. R., Dasgupta, S., Pyke, S. M., & Bell, S. G. (2019). Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates. Chemical Communications, 55(34), 5029-5032.
DOI Scopus12 WoS11 Europe PMC7
2017 Sharma, M., Rifkin, W., Tzioumis, V., Hill, M., Johnson, E., Varsavsky, C., . . . Pyke, S. (2017). Implementing and investigating distributed leadership in a national university network - SaMnet. Journal of Higher Education Policy and Management, 39(2), 169-182.
DOI Scopus8 WoS6
2015 Barrie, S., Bucat, R., Buntine, M., Burke da Silva, K., Crisp, G., George, A., . . . Yeung, A. (2015). Development, evaluation and use of a Student Experience Survey in undergraduate science laboratories: the Advancing Science by Enhancing Learning in the Laboratory Student Laboratory Learning Experience Survey. International Journal of Science Education, 37(11), 1795-1814.
DOI Scopus35 WoS29
2014 Priest, S., Pyke, S., & Williamson, N. (2014). Student perceptions of chemistry experiments with different technological interfaces: a comparative study. Journal of Chemical Education, 91(11), 1787-1795.
DOI Scopus9 WoS6
2013 Williamson, N., Metha, G., Willison, J., & Pyke, S. (2013). Development of POGIL-Style classroom activities for an introductory chemistry course. International Journal of Innovation in Science and Mathematics Education, 21(5), 27-41.
Scopus5
2011 Yeung, A., Pyke, S., Sharma, M., Barrie, S., Buntine, M., Burke Da Silva, K., . . . Lim, K. (2011). The Advancing Science by Enhancing Learning in the Laboratory (ASELL) Project: The first Australian multidisciplinary workshop. International Journal of Innovation in Science and Mathematics Education, 19(2), 51-72.
Scopus20
2011 Simpson, B., Claudie, D., Gerber, J., Pyke, S., Wang, J., McKinnon, R., & Semple, S. (2011). In vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra. Journal of Natural Products, 74(4), 650-657.
DOI Scopus28 WoS26 Europe PMC15
2010 Bedgood, D. R., Gardiner, M., Yates, B., Bridgeman, A. J., Morris, G., Buntine, M., . . . Zadnik, M. (2010). THE DEVELOPMENT OF TEACHING SKILLS TO SUPPORT ACTIVE LEARNING IN UNIVERSITY SCIENCE (ALIUS). JOURNAL OF LEARNING DESIGN, 3(3), 10-19.
DOI WoS4
2009 Basu Baul, T., Das, P., Chandra, A., Mitra, S., & Pyke, S. (2009). The synthesis, characterization and structures of some 4-[((E)-1-{2-hydroxy-5-[(E)-2-(aryl)-1-diazenyl]phenyl}methylidene)amino]benzoic acid. Dyes and Pigments, 82(3), 379-386.
DOI Scopus24 WoS24
2008 Smith, J., Jones, R., Booker, G., & Pyke, S. (2008). Sequential and Selective Buchwald-Hartwig Amination Reactions for the Controlled Functionalization of 6-Bromo-2-chloroquinoline: Synthesis of Ligands for the Tec Src Homology 3 Domain. Journal of Organic Chemistry, 73(22), 8880-8892.
DOI Scopus38 WoS35 Europe PMC14
2008 Kerr, P., Pyke, S., & Ward, A. (2008). Synthesis and cyclization to aurones and flavones of alkoxy-substituted aryl arylalkynyl ketones. Australian Journal of Chemistry, 61(5), 350-358.
DOI Scopus8 WoS8
2008 Burcham, P., Kaminskas, L., Tan, D., & Pyke, S. (2008). Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury. Mini - Reviews in Medicinal Chemistry, 8(4), 319-330.
DOI Scopus31 WoS31 Europe PMC25
2007 Ndi, C., Semple, S., Griesser, H., Pyke, S., & Barton, M. (2007). Antimicrobial compounds from Eremophila serrulata. Phytochemistry, 68(21), 2684-2690.
DOI Scopus52 WoS48 Europe PMC21
2007 Ndi, C., Semple, S., Griesser, H., Pyke, S., & Barton, M. (2007). Antimicrobial compounds from the Australian desert plant Eremophila neglecta. Journal of Natural Products, 70(9), 1439-1443.
DOI Scopus51 WoS44 Europe PMC26
2007 Kaminskas, L., Pyke, S., & Burcham, P. (2007). Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs. Rapid Communications in Mass Spectrometry, 21(7), 1155-1164.
DOI Scopus16 WoS15 Europe PMC11
2006 Inglis, S., Jones, R., Booker, G., & Pyke, S. (2006). Synthesis of N-benzylated-2-aminoquinolines as ligands for the Tec SH3 domain. Bioorganic & Medicinal Chemistry Letters, 16(2), 387-390.
DOI Scopus30 WoS29 Europe PMC10
2006 Burcham, P., & Pyke, S. (2006). Hydralazine inhibits rapid acrolein-induced protein oligomerization: Role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection. Molecular Pharmacology, 69(3), 1056-1065.
DOI Scopus78 WoS75 Europe PMC65
2006 Davies, B., Herbert, M., Culbert, J., Pyke, S., Coller, J., Somogyi, A., . . . Sallustio, B. (2006). Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography. Journal of Chromatography. B, Analytical Techniques in the Biomedical and Life Sciences, 832(1), 114-120.
DOI Scopus17 WoS15 Europe PMC10
2005 Kaminskas, L., Pyke, S., & Burcham, P. (2005). Differences in lysine adduction by acrolein and methyl vinyl ketone: Implications for cytotoxicity in cultured hepatocytes. Chemical Research in Toxicology, 18(11), 1627-1633.
DOI Scopus29 WoS29 Europe PMC17
2005 Clements, P., Gream, G., Kirkbride, P., & Pyke, S. (2005). Cycloaddition reactions of 7-benzylidenecycloocta-1,3,5-triene with ethenetetracarbonitrile and 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione. Helvetica Chimica Acta, 88(7), 2003-2021.
DOI Scopus6 WoS5
2005 Inglis, S., Jones, R., Fritz, D., Stojkoski, C., Booker, G., & Pyke, S. (2005). Synthesis of 5-, 6- and 7-substituted-2-aminoquinolines as SH3 domain ligands. Organic & Biomolecular Chemistry, 3(14), 2543-2557.
DOI Scopus30 WoS27 Europe PMC16
2004 Inglis, S., Stojkoski, C., Branson, K., Cawthray, J., Fritz, D., Wiadrowski, E., . . . Booker, G. (2004). Identification and specificity studies of small-molecule ligands for SH3 protein domains. Journal of Medicinal Chemistry, 47(22), 5405-5417.
DOI Scopus75 WoS71 Europe PMC41
2004 Kaminskas, L., Pyke, S., & Burcham, P. (2004). Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde. Organic & Biomolecular Chemistry, 2(18), 2578-2584.
DOI Scopus50 WoS48 Europe PMC34
2004 Kaminskas, L., Pyke, S., & Burcham, P. (2004). Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice. Journal of Pharmacology and Experimental Therapeutics, 310(3), 1003-1010.
DOI Scopus72 WoS69 Europe PMC53
2004 Burcham, P., Fontaine, F., Kaminskas, L., Petersen, D., & Pyke, S. (2004). Protein adduct-trapping by hydrazinophthalazine drugs: Mechanisms of cytoprotection against acrolein-mediated toxicity. Molecular Pharmacology, 65(3), 655-664.
DOI Scopus62 WoS58 Europe PMC46
2003 Burcham, P., Fontaine, F., Petersen, D., & Pyke, S. (2003). Reactivity with tris(hydroxymethyl)aminomethane confounds immunodetection of acrolein-adducted proteins. Chemical Research in Toxicology, 16(10), 1196-1201.
DOI Scopus14 WoS14 Europe PMC7
2003 Creaser, S., Pyke, S., & Lincoln, S. (2003). Complexation of zinc(II) and cadmium(II) by hydroxyethyl- and bis(hydroxyethyl)-1,4,7-triazacyclononane in water. Australian Journal of Chemistry, 56(1), 61-64.
DOI Scopus3 WoS2
2002 Johnstone, K., Pearce, W., & Pyke, S. (2002). Porphyrin building blocks: using a modified Barton-Zard approach to construct annulated pyrroles. Journal of Porphyrins and Phthalocyanines, 6(11-12), 661-672.
DOI Scopus6 WoS7
2002 Burcham, P., Kaminskas, L., Fontaine, F., Petersen, D., & Pyke, S. (2002). Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products. Toxicology, 182-182, 229-236.
DOI Scopus95 WoS95 Europe PMC70
2002 Crossley, M., King, L., Pyke, S., & Tansey, C. (2002). Reaction of 5-nitro-octaethylporphyrins with nucleophiles. Journal of Porphyrins and Phthalocyanines, 6(11-12), 685-694.
DOI WoS26
2001 Kerr, P., Pyke, S., Ward, A., & Tiekink, E. (2001). Crystal structure of (Z)-3-(1,3-benzodioxol-5-yl)-3-chloro-1-[2,4-di(benzyl-oxy)-6-hydroxyphenyl]-2-propen-1-one, C₃₀H₂₃ClO₆. Zeitschrift fur Kristallographie-New Crystal Structures, 216(4), 558-560.
Scopus3 WoS3
2001 Kerr, P., Pyke, S., Ward, A., & Tiekink, E. (2001). Crystal structure of 1-[2,4-di(benzyloxy)-6-hydroxyphenyl]-3-phenyl-2-propyn-1-one, C₂₉H₂₂O₄. Zeitschrift fur Kristallographie-New Crystal Structures, 216(1-4), 565-566.
DOI Scopus2 WoS2
2001 Kerr, P., Pyke, S., Ward, A., & Tiekink, E. (2001). Crystal structure of (E)-1,3-di(2,4,6-trimethoxyphenyl)-2-propen-1-one,C₂₁H₂₄O₇. Zeitschrift fur Kristallographie-New Crystal Structures, 216(4), 567-568.
Scopus1 WoS1
2001 Creaser, S., Pyke, S., & Tiekink, E. (2001). Crystal structure of N1-(1-oxohexahydro-1λ⁶-thiopyran-1-yliden)-1-benzenesulfonamide, C₁₂H₁₇NO₃S₂. Zeitschrift fur Kristallographie-New Crystal Structures, 216(3), 447-448.
Scopus1 WoS1
2001 Creaser, S., Pyke, S., & Tiekink, E. (2001). Crystal structure of N1-(hexahydro-1λ⁶-thiopyran-1-yliden)-1-benzenesulfonamide, C₁₂H₁₇NO₂S₂. Zeitschrift fur Kristallographie-New Crystal Structures, 216(3), 445-446.
Scopus2 WoS1
2001 Pearce, W., Pyke, S., & Tiekink, E. (2001). Crystal structure of 1-(4-nitrophenyl)-3-(phenylsulfonyl)-2,5-dihydro-1H-pyrrole, C₁₆H₁₄N₂O₄S. Zeitschrift fur Kristallographie-New Crystal Structures, 216(1-4), 529-530.
DOI Scopus1 WoS1
2001 Creaser, S., Pyke, S., & Tiekink, E. (2001). Crystal structure of N1-(4,4-dimethoxyhexahydro-1 λ⁶-thiopyran-1-yliden)-4-methyl-1-benzenesulfonamide, C₁₄H₂₁1NO₄S₂. Zeitschrift fur Kristallographie-New Crystal Structures, 216(3), 449-450.
DOI Scopus3
2001 Creaser, S., Pyke, S., & Tiekink, E. (2001). Crystal structure of N1-(3,3-dimethyl-9-oxo-1,5-dioxa-9λ⁶-thiaspiro[5.5]undec-9-yliden)-1-benzenesulfonamide,C₁₇H₂₅NO₄S₂. Zeitschrift fur Kristallographie-New Crystal Structures, 216(3), 451-453.
2001 Rozek, T., Bowie, J., Pyke, S., Skelton, B., & White, A. (2001). A regio- and stereo-selective synthesis of 2-hydroxy-3-methylochromycinone in three steps from 2-bromo-5-acetoxy-1,4-naphthoquinone and 1-acetoxy-3,3-dimethyl-5-vinylcyclohexa-1,5-diene. Organic & Biomolecular Chemistry, 1(15), 1826-1830.
DOI Scopus19 WoS18
2001 Basu Baul, T., Dhar, S., Pyke, S., Tiekink, E., Rivarola, E., Butcher, R., & Smith, F. (2001). Synthesis and characterization of triorganotin(IV) complexes of 5-[(E)-2-(aryl)-1-diazenyl]-2-hydroxybenzoic acids.: Crystal and molecular structures of a series of triphenyltin 5-[(E)-2-(aryl)-1-diazenyl]-2-hydroxybenzoates (aryl=phenyl, 2-methylphenyl, 3-methylphenyl and 4-methoxyphenyl). Journal of Organometallic Chemistry, 633(01-Feb), 7-17.
DOI Scopus87
2001 Avery, T., Fallon, G., Greatrex, B., Pyke, S., Taylor, D., & Tiekink, E. (2001). Mechanistic investigations on the reaction between 1,2-dioxines and bulky stabilized phosphorus ylides: An efficient route to closely related cyclopropane stereoisomers. Journal of Organic Chemistry, 66(24), 7955-7966.
DOI Scopus42 WoS44 Europe PMC20
2001 Bruce, M., Pyke, S., Zaitseva, N., Skelton, B., & White, A. (2001). Reactions of ethyne with some ruthenium cluster complexes containing dppm. Helvetica Chimica Acta, 84(10), 3197-3215.
DOI Scopus12 WoS8
2001 Semple, S., Pyke, S., Reynolds, G., & Flower, R. (2001). In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral Research, 49(3), 169-178.
DOI Scopus144 WoS112 Europe PMC67
2001 Creaser, S., Pyke, S., & Tiekink, E. (2001). N-(4,4-Dimethoxy-1-oxo-1λ⁶-thianylidene)-4-methyl-1-benzenesulfonamide. Acta Crystallographica Section E-Structure Reports Online, 57(Part 5), O394-O395.
DOI
2001 Kerr, P. J., Pyke, S. M., Ward, A. D., & Tiekink, E. R. T. (2001). Crystal structure of (E)-1,3-di(2,4,6-trimethoxyphenyl)-2-propen-1-one, C21H24O7. Zeitschrift Fur Kristallographie New Crystal Structures, 216(1-4), 601-602.
DOI
2001 Creaser, S. P., Pyke, S. M., & Tiekink, E. R. T. (2001). Crystal structure of N1-(3,3-dimethyl-9-oxo-l,5-dioxa-9λ6-thiaspiro[5.5]-undec-9-yliden)-1-benzenesulfonamide, C17H25NO4S2. Zeitschrift Fur Kristallographie New Crystal Structures, 216(1-4), 473-475.
DOI
2001 Creaser, S. P., Pyke, S. M., & Tiekink, E. R. T. (2001). Crystal structure of N1-(hexahydro-1λ6-thiopyran-1-yliden)-1-benzenesulfonamide, C12H17NO2S2. Zeitschrift Fur Kristallographie New Crystal Structures, 216(1-4), 467-468.
DOI Scopus1
2001 Creaser, S. P., Pyke, S. M., & Tiekink, E. R. T. (2001). Crystal structure of N1-(1-oxohexahydro-1λ6-thiopyran-1-yliden)-1-benzenesulfonamide, C12H17NO3S2. Zeitschrift Fur Kristallographie New Crystal Structures, 216(1-4), 469-470.
DOI
2001 Kerr, P. J., Pyke, S. M., Ward, A. D., & Tiekink, E. R. T. (2001). Crystal structure of (Z)-3-(1,3-benzodioxol-5-yl)-3-chloro-1-[2,4-di(benzyloxy)-6-hydroxyphenyl]-2-propen-1-one, C30H23ClO6. Zeitschrift Fur Kristallographie New Crystal Structures, 216(1-4), 592-594.
DOI
2001 Baul, T. S. B., Dhar, S., Pyke, S. M., Tiekink, E. R. T., Rivarola, E., Butcher, R., & Smith, F. E. (2001). Synthesis and characterization of triorganotin(IV) complexes of 5-[(<i>E</i>)-2-(aryl)-1-diazenyl]-2-hydroxybenzoic acids.: Crystal and molecular structures of a series of triphenyltin 5-[(<i>E</i>)-2-(aryl)-1-diazenyl]-2-hydroxybenzoates (aryl = phenyl, 2-methylphenyl, 3-methylphenyl and 4-methoxyphenyl). JOURNAL OF ORGANOMETALLIC CHEMISTRY, 633(1-2), 7-17.
WoS80
2000 Crisp, M., Pyke, S., & Rendina, L. (2000). Dinuclear organoplatinum (II)-methyldiphenylphosphine complexes of nicotinic acid. Journal of Organometallic Chemistry, 607(1-2), 222-226.
DOI Scopus12 WoS11
1999 Basu Baul, T., Dahr, S., Kharbani, N., Pyke, S., Butcher, R., & Smith, F. (1999). Synthesis and structural characterization of some triorganotin(IV) complexes of 5-(4-chlorophenulazo)salicylic acid: Crystal and molecular structure of triphenyltin 5-(4-chlorophenylazo)salicylate 0.5C₆H₁₄. Main Group Metal Chemistry, 22(7), 413-421.
DOI Scopus31 WoS30
1999 De Vos, D., Clements, P., Pyke, S. M., Smyth, D. R., & Tiekink, E. R. T. (1999). Characterisation and in vitro cytotoxicity of triorganophosphinegold(I) 2-mercaptobenzoate complexes. Metal Based Drugs, 6(1), 31-40.
DOI Scopus41 Europe PMC10
1999 Creaser, S., Lincoln, S., & Pyke, S. (1999). A general method for the preparation of single pendant arm 2-hydroxyalkyl-1,4,7-triazacyclononane macrocycles. Journal of the Chemical Society, Perkin transactions I, 1(9), 1211-1213.
DOI Scopus14 WoS10
1999 Semple, S., Nobbs, S., Pyke, S., Reynolds, G., & Flower, R. (1999). Antiviral flavanoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine. Journal of Ethnopharmacology, 68(1-3), 283-288.
DOI Scopus73 WoS49 Europe PMC25
1998 Pearce, W., Pyke, S., & Tiekink, E. (1998). Crystal structure of ethyl 3,3-dimethyl-5,7-dihydro-H[1,3]dioxepino[5,6-c]=pyrrole-6-carboxylate, C12H17NO4. Zeitschrift fur Kristallographie, 213(1-4), 61-62.
DOI Scopus1 WoS1
1998 Creaser, S. P., Lincoln, S. F., Pyke, S. M., & Tiekink, E. R. T. (1998). Crystal structure of 1,4,7-triazabicyclo[4.3.0]non-6-ene-5-one, C6H9N3O. Zeitschrift Fur Kristallographie New Crystal Structures, 213(1-4), 41.
DOI Scopus1
1998 Kosovel, F. J., Pyke, S. M., & Tiekink, E. R. T. (1998). Redetermination of the crystal structure of 5-methyl-2-thiocytosine hemihydrate, C5H7N3S 0.5H2O, at 213 K. Zeitschrift Fur Kristallographie New Crystal Structures, 213(1-4), 40.
DOI
1998 Creaser, S., Lincoln, S., Pyke, S., & Tiekink, E. (1998). Crystal structure of 1,4,7-triazabicyclo[4.3.0]non-6-ene-5-one, C6H9N3O. Zeitschrift fur Kristallographie, 213(1), 41.
WoS1
1998 Kosovel, F., Pyke, S., & Tiekink, E. (1998). Redetermination of the crystal structure of 5-methyl-2-thiocytosine hemihydrate, C5H7N3S 0.5H2O, at 213K. Zeitschrift fur Kristallographie, 213(1), 40.
1996 Tiekink, E., Creaser, S., & Pyke, S. (1996). Crystal structure of 3,3-dimethyl-1,5-dioxa-9-thiaspiro[5.5]-undecane-9-oxide,9-N-[(4-methyl-benzenesulfonyl)imine], C17H25NO5S2. Zeitschrift fur Kristallographie, 211(8), 573-574.
DOI
1996 Tiekink, E., Pearce, W., & Pyke, S. (1996). Crystal structure of (3R*,4R*) 3-iodi-4-(4'-methylbenzenesulfonyl)oxolane, C11H13IO3S. Zeitschrift fur Kristallographie, 211(6), 421-422.
DOI
1996 Tiekink, E., Basu Baul, T., Pyke, S., & Sarma, K. (1996). Crystal and molecular structure of aquatriphenyltin 2-(3-formyl-4-hydroxyphenylazo) benzoate. Main Group Metal Chemistry, 19(12), 807-814.
DOI Scopus32 WoS31
1996 Pyke, S., Graham, A., Loughlin, W., Moore, M., Wilson, G., & Taylor, R. (1996). The generation and synthetic applications of episulfone α-anions. Journal of the Chemical Society, Perkin Transactions 1, (7), 661-667.
DOI Scopus14 WoS13
1994 Guo, Z. X., Haines, A. H., Pyke, S. M., Pyke, S. G., & Taylor, R. J. K. (1994). Improved preparation of (±)-(1,3/2,4)-5-cyclohexene-1,2,3,4-tetrol [(±)-conduritol-B] and its reaction with hydrobromic and hydrochloric acid; synthesis and characterisation of some (±)-1-deoxy-1-halo- and (±)-1,4-dideoxy-1,4-dihaloconduritols. Carbohydrate Research, 264(1), 147-153.
DOI Scopus31 WoS32 Europe PMC10
1993 EWIN, R. A., LOUGHLIN, W. A., PYKE, S. M., MORALES, J. C., & TAYLOR, R. J. K. (1993). THE ISOLATION OF EPISULFONES FROM THE RAMBERG-BACKLUND REARRANGEMENT .3.. SYNLETT, 1993(9), 660-662.
DOI WoS10
1993 Jeffery, S. M., Sutherland, A. G., Pyke, S. M., Powell, A. K., & Taylor, R. J. K. (1993). Isolation of episulfones from the Ramberg-Bäcklund rearrangement. Part 2. X-ray molecular structure of 2,3-epithio-8,8-dimethyl-6,10- dioxaspiro[4.5]-decane S,S-dioxide and of r-6-benzyl-t-7,t-8-epithio-1,4- dioxaspiro[4.4]nonane S,S-dioxide. Journal of the Chemical Society Perkin Transactions 1, (19), 2317-2327.
DOI Scopus25 WoS19
1991 Crossley, M. J., Burn, P. L., Langford, S. J., Pyke, S. M., & Stark, A. G. (1991). A new method for the synthesis of porphyrin-α-diones that is applicable to the synthesis of trans-annular extended porphyrin systems. Journal of the Chemical Society Chemical Communications, (21), 1567-1568.
DOI Scopus99 WoS91
1987 Crossley, M. J., King, L. G., & Pyke, S. M. (1987). A new and highly efficient synthesis of hydroxyporphyrins. Tetrahedron, 43(20), 4569-4577.
DOI Scopus70 WoS67

Year Citation
2022 Swan, E., Jayne, S., & Pyke, S. (2022). Recent Developments in Targeting "Undruggable" SH3 Domains. In J. Bronson, B. Savall, & R. Hudkins (Eds.), 2021 Medicinal Chemistry Reviews (Vol. 56, pp. 389-411). American Chemical Society.
DOI
2016 Schmid, S., Schultz, M., Priest, S., O'Brien, G., Pyke, S., Bridgeman, A., . . . Jamie, I. (2016). Assessing the assessments: Development of a tool to evaluate assessment items in chemistry according to learning outcomes. In M. Schultz, S. Schmid, & T. Holme (Eds.), Technology and Assessment Strategies for Improving Student Learning in Chemistry (Vol. 1235, 1 ed., pp. 225-244). Washington: American Chemical Society.
DOI Scopus6 WoS4
2008 Taylor, R. J. K., Pyke, S. G., & Pyke, S. M. (2008). Natural products containing the cyclopentane sub-unit: Prostaglandins. In Second Supplements to the 2nd Edition of Rodd S Chemistry of Carbon Compounds A Modern Comprehensive Treatise (Vol. 2, pp. 221-282).
DOI Scopus4
1991 Taylor, R. J. K., Pyke, S. G., & Pyke, S. M. (1991). Natural products containing the cyclopentane sub-unit. In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds (pp. 221-282). Elsevier.
DOI

Year Citation
2014 Priest, S. J., Williamson, N. M., & Pyke, S. M. (2014). Capabilities and Limitations of the Advancing Science by Enhancing Learning in the Laboratory Project Student Learning Evaluation Data. In Proceedings of the RACI National Congress. Adelaide.
2012 Williamson, N. M., Huang, D. M., Pyke, S. M., Willison, J., & Metha, G. F. (2012). Constructing a First Year University Chemistry Course for the ‘Late Bloomers’. In ERGA 2012 Proceedings. Adelaide.
2012 Priest, S. J., Pyke, S. M., Williamson, N. M., & Willison, J. (2012). Representations of Scientific Concepts and Learning Experience of First Year Undergraduate Students. In ERGA 2012 Proceedings. Adelaide.
2010 Barrie, S. C., Buntine, M. A., da Silva, K. B., Lim, K., Pyke, S., Sharma, M., . . . Kable, S. H. (2010). Improving student engagement in the laboratory: An initiative across all Australian universities. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 240 (pp. 1 page). AMER CHEMICAL SOC.
2010 Pyke, S. (2010). An initiative in introducing iPads to higher education. In The Education Research Group of Adelaid (pp. The Changing Face of Education, 24-25 September, 2010). Adelaide, Australia.
1995 Cooper, M. A., Pyke, S. M., & Ward, A. D. (1995). Unusually stable hydrates of N-substituted 3-hydroxy-2-(phenylselenenyl)methylpiperidine derivatives. Where is the water? An NMR study.. In D. G. Gorenstein (Ed.), BULLETIN OF MAGNETIC RESONANCE, VOL 17, NOS 1-4, DECEMBER 1995 (pp. 244-245). SYDNEY, AUSTRALIA: INT SOC MAGNETIC RESONANCE.

Year Citation
2015 Pyke, S. M., Porter-Dabrowski, C., & Williamson, N. M. (2015). Student Attitudes and Approaches to Learning Chemistry: What Influences Academic Success?. Poster session presented at the meeting of Proceedings of the Australian Conference on Science and Mathematics Education. Perth.
2014 Pyke, S. M., Porter-Dabrowski, C., & Williamson, N. M. (2014). Impact of Student Approaches to Learning on Both Their Experience and Their Performance in Problem Solving Workshop Classes: A Pilot Study. Poster session presented at the meeting of Proceedings of the Australian Conference on Science and Mathematics Education. Sydney.
2012 Priest, S. J., Williamson, N. M., & Pyke, S. M. (2012). Thinking Beyond the Macro Domain of Chemistry in First Year Undergraduate Students. Poster session presented at the meeting of Poceedings of Chem Ed 2012. Adelaide.
2012 Priest, S. J., Pyke, S. M., Williamson, N. M., & Willison, J. (2012). Using Laboratory Experiences to Investigate Learning Trends in Chemistry. Poster session presented at the meeting of Proceedings of the Australian Conference on Science and Mathematics Educatio. Sydney.
Year(s) Title (Source) Role Amount
Grants related to Learning & Teaching
2015-17 Advancing Science and Engineering through Laboratory Learning: ASELL for Schools

Australian Science & Mathematics Partnership Program		 Co-Investigator $ 1,912,000
2014-16 Assessing the assessments: evidencing and benchmarking student learning outcomes in chemistry

Office of Learning & Teaching (Grant ID ID14-3652)		 Co-Investigator $ 217,000
2009-11 Advancing Science by Enhancing Learning in the Laboratory

Australian Learning & Teaching Council (Grant ID CG9-1049) 		Co-Investigator $ 219,000
2009 Clarifying and consolidating generic skill expectation and outcomes across core Level I Science Offerings

University of Adelaide, Learning & Teaching Performance Fund 		Chief Investigator $ 40,000
2008-10 Developing leaders of change in the teaching of large university chemistry classes

Australian Learning & Teaching Council (Grant ID LE8-818)		 Co-Investigator

$ 111,000
2006 Establishing a uniform student experience of courses

University Learning & Teaching Development Grant 		Chief Investigator $ 78,879
Year(s) Title (Source) Role Amount
Grants related to Research
2006-08 Protecting lung cells against the damaging effects of toxic chemicals present in inhaled smoke

NHMRC (Application ID 403967)		 Co-Investigator $ 447,750
2004-05 Enantioselectivity in the clinical pharmacology of perhexiline: the key to a new antianginal agent?

National Heart Foundation		 Co-Investigator $ 100,000

 

Simon has been the Program Coordinator for the Bachelor of Science since 2007 and made substantial contributions to the design of the Bachelor of Science (Advanced) program launched in 2011 (he was the inaugural Program Coordinator). He designed, developed and delivered the core course 'Principles & Practice of Science I' (2011-2016) which focused on development of core academic skills for students in the Bachelor of Science and Bachelor of Science (Advanced) programs, and introduced these students to what it means to 'be a scientist'. In addition, Simon also teaches Chemistry courses from 1st year to Honours level. The quality of his teaching has been recognised by numerous awards at institutional. state and national levels.

Years Level Course Section
Teaching responsibilities
1993-2006 I Chemistry IB Synthetic & Bio-organic Chemistry
2008-present I Chemistry IB Molecular Shape & Structure Determination
2011-2016 I Principles & Practice of Science I Whole course
2017 I Principles & Practice of Research (Advanced) I Whole course
2002-2006 II Chemistry IIA Synthetic Chemistry
2009-present II Medicinal & Biological Chemistry II Introduction to Medicinal Chemistry
2017 II Environmental & Analytical Chemistry II Separation Science
1993- present III Chemistry III Spectroscopy & Structure Determination
1992-2011 Hons Honours Chemistry Advanced NMR Spectroscopy & Structure Determination
2014 Hons/PG Demonstrator Development & Training Whole course

 

Date Role Research Topic Program Degree Type Student Load Student Name
2021 Co-Supervisor Characterisation of Snake Venom Proteins to Inform New Advances in Biotechnology Doctor of Philosophy Doctorate Part Time Mr Lewis Owen McFarlane
2021 Co-Supervisor Characterisation of Snake Venom Proteins to Inform New Advances in Biotechnology Doctor of Philosophy Doctorate Part Time Mr Lewis Owen McFarlane
2019 Principal Supervisor Investigating the Attitudes of Primary School Teachers Towards Science and Mathematics Doctor of Philosophy Doctorate Part Time Miss Thao Hong Duong
2019 Principal Supervisor Investigating the Attitudes of Primary School Teachers Towards Science and Mathematics Doctor of Philosophy Doctorate Full Time Miss Thao Hong Duong

Date Role Research Topic Program Degree Type Student Load Student Name
2019 - 2023 Principal Supervisor Development of 2-Aminoquinoline Derivatives with Improved Drug-Like Character as Small Molecule Inhibitors for a Protein-Protein Interaction Domain Doctor of Philosophy Doctorate Part Time Ms Ellen Lillian Swan
2019 - 2023 Co-Supervisor Understanding cytochrome P450 cholesterol metabolism in bacteria Doctor of Philosophy Doctorate Full Time Dr Amna Ghith
2018 - 2022 Co-Supervisor Synthesis and Applications of Substituted Bullvalenes and The Synthesis of Bicyclo[4.2.0]octadiene Derived Natural Products Doctor of Philosophy Doctorate Full Time Mr Harshal Deepak Patel
2018 - 2020 Principal Supervisor Synthesis and Network Analysis of Substituted Bullvalenes and the Total Synthesis of Endiandric Acid J and Beilcyclone A Doctor of Philosophy Doctorate Full Time Mr Ossama Yahiaoui
2018 - 2020 Co-Supervisor Exploring the Monooxygenase Activity and Selectivity of Two Related Cytochrome P450 Enzymes Master of Philosophy Master Full Time Mr Saurabh Kumar Ahirwar
2018 - 2023 Principal Supervisor Wild Nicotiana: Profiling the Alkaloids of Australian Species Doctor of Philosophy Doctorate Full Time Dr Samantha Dama
2017 - 2021 Principal Supervisor Assessing the Validity of Multiple-Choice Questions, Using them to undertake Comparative Analysis on Student Cohort Performance, and Evaluating the Methodologies Used Doctor of Philosophy Doctorate Full Time Mr Jacob Rhys Marchant
2017 - 2021 Co-Supervisor The Total Synthesis of Natural Products via Cascade Reactions Doctor of Philosophy Doctorate Full Time Miss Laura Jane Burchill
2017 - 2021 Co-Supervisor The Synthesis of Chromane Meroterpenoids via Biomimetic Cascade Reactions Doctor of Philosophy Doctorate Full Time Mr Aaron John Day
2015 - 2019 Principal Supervisor Pretty Keen for a Protein: Development of Small Molecule Inhibitors for a Protein-Protein Interaction Domain Doctor of Philosophy Doctorate Full Time Miss Stephanie Jayne
2015 - 2019 Co-Supervisor Application of the Monooxygenase Enzymes CYP101B1 and CYP101C1 from Novosphingobium aromaticivorans for Selective and Efficient Functionalisation of Inert C-H Bonds Doctor of Philosophy Doctorate Full Time Mr Md Raihan Sarkar
2014 - 2018 Co-Supervisor Deciphering Electron Transfer and Cytochrome P450 Activity in Mycobacterium marinum Doctor of Philosophy Doctorate Full Time Ms Stella Agnes Child
2014 - 2016 Principal Supervisor Investigations and Applications of Self-Sufficient Cytochrome P450 Monooxygenases Master of Philosophy Master Full Time Mr Samuel David Munday
2012 - 2013 Co-Supervisor Aspects of Organoselenium Chemistry Doctor of Philosophy Doctorate Part Time Ms Virginia Ward
2012 - 2017 Principal Supervisor Valid Measurement of Laboratory Learning Experience Quality from the Student Perspective Doctor of Philosophy Doctorate Part Time Samuel James Priest
2011 - 2016 Principal Supervisor Investigation of a Novel Toxin Produced By A Limnothrix Cyanobacteria Doctor of Philosophy Doctorate Full Time Dr Faye Titania Whan
2007 - 2009 Principal Supervisor Isolation, Structural Elucidation and Antibacterial Activity of the Chemical Constituents of Scaevola Spinescens Master of Science Master Full Time Ms Michele Mejin
2006 - 2009 Principal Supervisor Development of 2-Aminoquinoline Derivatives as Ligands for Tec SH3 Domain Doctor of Philosophy Doctorate Full Time Mrs Jessica Smith
2005 - 2013 Co-Supervisor Structure-function Studies and In Silico Drug Discovery Targeting the Liver Oncoprotein Gankyrin Doctor of Philosophy Doctorate Full Time Mr Iain Murchland
2004 - 2008 Principal Supervisor Investigating 2-Aminoquinoline Derivatives as Small Molecule Ligands for the Tec SH3 Domain Doctor of Philosophy Doctorate Full Time Miss Rhiannon Jones
2003 - 2006 Co-Supervisor Amphibian Neuropeptides: Isolation, Sequence Determination and Bioactivity Doctor of Philosophy Doctorate Full Time Ms Vita Maselli
2003 - 2006 Co-Supervisor Negative Ion Mass Spectrometry of Peptides An Aid to Structure Determination Doctor of Philosophy Doctorate Full Time Dr Daniel Bilusich
2003 - 2011 Co-Supervisor Studies in Molecular, Supramolecular and Macromolecular Design Doctor of Philosophy Doctorate Full Time Mr Oscar Archer
2001 - 2004 Co-Supervisor PROTECTION AGAINST a,b-UNSATURATED ALDEHYDE TOXICITY BY HYDRAZINOPHTHALAZINE COMPOUNDS. Doctor of Philosophy Doctorate Full Time Ms Lisa Kaminskas
2001 - 2005 Co-Supervisor Development of Small-Molecule Ligands for SH3 Protein Domains Doctor of Philosophy Doctorate Full Time Mr Steven Inglis

Date Role Committee Institution Country
2015 - ongoing Member Academic Board University of Adelaide Australia
2012 - 2013 Chair Chemistry Threshold Learning Outcomes Working Party ChemNet (Office of Learning & Teaching) Australia
2011 - ongoing Member Quality Assurance Integrity Panel SACE Board of South Australia Australia
2011 - 2013 Member Science & Mathematics Network (SaNnet) Steering Committee SaMnet (Office of Learning & Teaching) Australia
2009 - 2011 Member Learning & Teaching Academic Standards Advisory Group (Science) Australian Learning & Teaching Council Australia
2008 - ongoing Member Accreditation, Recognition & Certification Committee SACE Board of South Australia Australia
2006 - ongoing Member University Learning Committee University of Adelaide Australia
2006 - ongoing Member Program Approval & Entry Committee University of Adelaide Australia

Date Role Membership Country
1995 - 2010 Member Australian & New Zealand Society for Magnetic Resonance Australia
1990 - ongoing Member Royal Society of Chemistry United Kingdom
1984 - ongoing Member Royal Australian Chemical Institute -

Connect With Me

External Profiles

Other Links