Head of Intestinal Nutrient Sensing Group
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Richard L Young is an Associate Professor, Senior Research Fellow and Postgraduate Coordinator within the Adelaide Medical School, and a Senior Research Fellow at the South Australian Health & Medical Research Institute (SAHMRI). He is a member of the Centre of Research Excellence in Translating Nutritional Science to Good Health (NHMRC 2013-2020), an exceptional framework for linking basic and clinical researchers in endocrinology and gastroenterology.
He leads the Intestinal Nutrient Sensing Group within SAHMRI which investigates the intestinal sweet taste system. This system detects dietary sugars and low-calorie sweeteners, and in response, can regulate the uptake and disposal of glucose in the body. His research has shown how this system is regulated in health and dysregulated in diabetes, critical illness and obesity. His research is focussed on the vertical integration of sweet and microbiome signals from the intestine to the whole body, and new avenues to better treat type 2 diabetes. He collaborates widely with clinicians, cell biologists, microbiologists and with industry. A/Prof Young also leads research within an ARC and industry collaboration with Flinders University investigating the intestinal serotonin system in humans. This system has novel and emerging roles in metabolic control, and is an exciting prospect for future novel therapies for obesity and Type 2 diabetes.
- Richard L Young leads the Intestinal Nutrient Sensing Group within SAHMRI Nutrition & Metabolism which investigates the intestinal sweet taste system. He has shown how this sensory system is regulated in health and dysregulated in human diabetes, critical illness and obesity and consequences for blood glucose control. He undertakes clinical and microbiological studies with low-calorie sweeteners in health and type 2 diabetes, and ex vivo studies with a novel tissue platform using human intestinal biopsies. This system has novel and emerging roles in metabolic control, and is an exciting prospect for future novel therapies for type 2 diabetes. He collaborates widely with clinicians, cell biologists, microbiologists and with industry in these inquiries.
Date Position Institution name 2016 Associate Professor The University of Adelaide
Date Institution name Country Title — University of Melbourne, Melbourne Australia PhD — University of Adelaide, Adelaide Australia BSc Honours — University of Adelaide, Adelaide Australia BSc
Year Citation 2018 Nam, Q. N., Naidu, J., Debricini, T., Burgess, J., Safaeian, R., Young, R., & Horowitz, M. (2018). Is dysregulation of intestinal glucose transporters in the morbidly obese responsible for the development of diabetes mellitus?. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 (pp. 218-219). WILEY. 2011 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. In DIABETOLOGIA Vol. 54 (pp. S330). Lisbon, PORTUGAL: SPRINGER. 2011 Little, T., Young, R., Blackshaw, L., Rayner, C., & Feinle-Bisset, C. (2011). Expression of the fatty acid sensors, CD36, GPR119 and GPR120, in the duodenum of humans. Relationships with obesity. In 19th Annual Meeting of the Society for the Study of Ingestive Behavior Vol. 575 (pp. S26). Netherlands: Elsevier BV.
2011 Young, R. L., Deane, A. M., Chia, B., Horowitz, M., Blackshaw, L. A., & Rayner, C. (2011). Dysregulation of Intestinal Glucose Transporter and Sweet Taste Receptor Expression in Critical Illness. In GASTROENTEROLOGY Vol. 140 (pp. S194). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2010 Isaacs, N., Flach, C., Young, R., Wittert, G., Blackshaw, L., & Page, A. (2010). Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice. In Proceedings Vol. 138 (pp. 0 pages). USA: W.B. Saunders Co..
2010 Harrington, A., Young, R., Brierley, S., & Blackshaw, L. (2010). TRPV1 mediates acid activation of esophageal sensory pathways. In Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting, NGM 2010 Vol. 22 (pp. 55). UK: Wiley-Blackwell Publishing Ltd. 2002 Young, R., Cooper, N., & Blackshaw, L. (2002). Neurochemical coding of gastric vago-vagal pathways in the ferret. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS.
- 2019-21 Project (APP1164475) Keating DJ, Young RL, Holst JJ, Knop FK. 'Targeting proglucagon cells in the human gut to treat diabetes and obesity'
- 2018-20 Project (APP1147333) Wu T, Rayner CK, Jones KL, Young RL, Feinle-Bisset C. 'Bitter taste as a mediator of food intake and postprandial glycaemia in health and type 2 diabetes'
- 2014-18 Project (APP1081182) Young RL, Rayner CK, Horowitz M ‘Why do sweetened drinks link to type 2 diabetes?’
- 2010-12 Project (APP627127) Young RL 'Glucose detection pathways in the gut'
Australian Research Council
- 2015-18 ARC Linkage (LP150100419) Keating DM, Young RL, Liou A, Jackson VM ‘Mechanisms controlling enteroendocrine hormone secretion in human duodenum’
- 2018-19 Millennium Award, Type 2 Diabetes. Young RL, Rayner CK, Horowitz M, Wu T. 'Do artificial sweeteners affect glycaemic control adversely in people with type 2 diabetes?'
- 2013 Research Grant. Young RL, Rayner CK, Blackshaw LA, Horowitz M. 'Postprandial consequences of intestinal sweet taste receptor dysregulation in type 2 diabetes'
- 2008 Research Grant. Young RL, Rayner CK, Blackshaw LA, Horowitz M. 'Characterisation of intestinal sweet-taste molecules in type-2 diabetes'
National Natural Science Foundation of China
- 2019-22 (81870561). Effects of intestinal bitter taste sensing on gastrointestinal hormone secretion and glycaemic control. Wu T, Rayner CK, Young RL, Lu Q, Wang D, Wang X, Chen J, Cai M, Ge M.
The Hospital Research Foundation
- 2018-20 (Translational Research) Young RL, Rayner CK, Rogers GB. 'A bitter tale of artificial sweeteners in Type 2 diabetes?'
- 2018-19 (Project, Inaugural Round) Young RL, Rayner CK, Rogers GB, Horowitz M. 'A bitter tale of artificial sweeteners in human health and Type 2 diabetes?'
Royal Adelaide Hospital
- 2018 Clinical Project (9747) Young RL, Nguyen NQ, Rayner CK, Wu T, Horowitz M. 'Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes'
- 2016 Clinical Project (2155) Wong S, Young RL, Nguyen NQ, Rayner CK. 'Impact of blocking intestinal glucose transporter 2 (GLUT2) on glucose absorption, glycaemic control and incretin responses in morbidly obese subjects with type 2 diabetes mellitus'
- 2014-16 Clinical Project (1772) Young RL, Wu T, Rayner CK. 'Intestinal sweet taste receptor control of glucose absorption in human health and type 2 diabetes'
2013-14 Clinical Project (1483) Young RL, Rayner CK, Nguyen N. 'Molecular determinants of glucose sensing in human gastrointestinal tract'
2012 Clinical Project (7849) Young RL, Deane AM. 'Protein determinants of intestinal carbohydrate malabsorption in critical illness'
2012 Clinical Project Symonds E, Young RL, Nguyen N. 'Evaluation of nutrient sensing in the large intestine and modulation by obesity
2011 (Special Research Project) Deane AM, Young RL. 'The intestinal glucose transporter SGLT-1 as a novel therapeutic target in critical illness'
Intensive Care Foundation Australia
2014 (Research Grant) Young RL, Deane AM. 'Intestinal GLP-2 as a novel target in critical illness-induced malabsorption'
2011 (Research Grant) Deane AM, Young RL, Chapman MJ, Rayner CK, Horowitz M. 'Critical illness & intestinal sweet taste receptors'
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Principal Supervisor Gut mechanisms linking artificial sweeteners to impaired glycaemic control Doctor of Philosophy Doctorate Full Time Miss Denise Kreuch
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2012 - 2017 Principal Supervisor Gastrointestinal Nutrient Sensing in Obesity and type 2 Diabetes: Role in Appetite Regulation and Glycaemic Control Doctor of Philosophy Doctorate Full Time Ms Nada Cvijanovic 2004 - 2009 Co-Supervisor Nutrient Sensing Mechanisms in the Small Intestine: Localisation of Taste Molecules in Mice and Humans With and Without Diabetes Doctor of Philosophy Doctorate Full Time Ms Kate Sutherland
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2014 - ongoing External Supervisor Isolation, purification and characterisation of human enteroendocrine cells Flinders University of South Australia School of Medicine, PhD Doctorate Full Time Emily Wai-Ling Sun
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