Richard Young

Associate Professor Richard Young

Head of Intestinal Nutrient Sensing Group

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

A/Prof Richard L Young is a Senior Research Fellow in the Adelaide Medical School at The University of Adelaide, and the South Australian Health & Medical Research Institute (SAHMRI). He is a member of the Centre of Research Excellence in Translating Nutritional Science to Good Health, which links basic and clinician researchers in world-leading research in diabetes.

A/Prof Young heads the Intestinal Nutrient Sensing Group within the Nutrition, Diabetes and Gut Health Program of SAHMRI Lifelong Health. He investigates the intestinal taste system, which detects dietary sugars and low-calorie sweeteners and, in turn, controls how glucose is absorbed and disposed in the body. He has shown how this system is regulated in health, and the consequences of its dysregulation in type 2 diabetes, critical illness and obesity. This research is supported by the NHMRC (Ideas 2020-23) and is providing new knowledge of gut physiology and microbiology, with the potential to prevent, and better manage, type 2 diabetes and obesity.

Research Projects

My group offers higher degree research projects that span interventional clinical research through to basic research with genetic and disease models. These projects aim to find new ways to treat diabetes and save lives in critical illness, and can be tailored to the individual student. Shorter honours projects are also available in these areas. Students will be based in the west-end health precinct in SAHMRI, with clinical studies undertaken in the nearby Royal Adelaide Hospital (RAH).

  • Can blocking gut sweet sensing improve blood glucose control for patients with type 2 diabetes? We've discovered that high and habitual consumption of low-calorie sweeteners can worsen control of blood glucose in healthy subjects. Patients with type 2 diabetes may be at even higher risk due an existing defect in sweet sensing in their gut. This project will investigate whether blocking sweet sensing in the gut improves control of blood glucose in patients with type 2 diabetes. This project will involve clinical research in the RAH and laboratory experiments in SAHMRI, in an effort to discover new ways to treat diabetes. Project start: Semester 1 and 2.
  • How does the human gut respond to sweet and bitter stimuli? This project will establish the precise mechanisms that link sensing of bitter (e.g. denatonium) and sweet (e.g. low-calorie sweeteners) in the gut wall and gut bacteria to signals that disrupt host control of blood glucose. This will involve functional and multi-omic experiments in human biopsy tissues and experiments examining gut bacteria in SAHMRI. Project start: Semester 1 and 2.
  • Saving lives in critical illness by preserving cortisol targeting Blood levels of the carrier protein for cortisol, corticosteroid-binding globulin, fall in patients with sepsis, and do so in a manner that predicts death and morbidity. Supplementing corticosteroid-binding globulin may preserve its unique capacity to target cortisol delivery in the critically ill. This utility is being testing first in our mouse model, which responds the same as patients. This research will provide fundamental knowledge on sepsis timing, corticosteroid-binding globulin dose, and the utility to save lives and reduce morbidity. This is an exciting space, and has the promise to deliver the first new therapy for critical illness in over thirty years. This project will involve clinical research in the RAH and laboratory experiments in SAHMRI. Project start: Semester 1 and 2.
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  • Journals
    Year Citation
    2021 Overduin, T. S., Page, A. J., Young, R. L., & Gatford, K. L. (2021). Adaptations in gastrointestinal nutrient absorption and its determinants during pregnancy in monogastric mammals. JBI Evidence Synthesis, Publish Ahead of Print.
    DOI
    2021 Nunez-Salces, M., Li, H., Feinle-Bisset, C., Young, R. L., & Page, A. J. (2021). The regulation of gastric ghrelin secretion. Acta Physiologica, 231(3), 20 pages.
    DOI Scopus1 WoS1 Europe PMC1
    2021 Sun, E. W., Martin, A. M., de Fontgalland, D., Sposato, L., Rabbitt, P., Hollington, P., . . . Keating, D. J. (2021). Evidence for glucagon secretion and function within the human gut. Endocrinology, 162(4), 4-12.
    DOI
    2021 Xie, C., Huang, W., Wang, X., Trahair, L. G., Pham, H. T., Marathe, C. S., . . . Wu, T. (2021). Gastric emptying in health and type 2 diabetes: an evaluation using a 75g oral glucose drink. Diabetes Research and Clinical Practice, 171, 1-8.
    DOI Scopus1 WoS1
    2021 Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., . . . Keating, D. J. (2021). A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans. Gastroenterology, 161(2), 536-547.
    DOI Scopus1 WoS1 Europe PMC1
    2021 Li, H., Clarke, G. S., Christie, S., Ladyman, S. R., Kentish, S. J., Young, R. L., . . . Page, A. J. (2021). Pregnancy-related plasticity of gastric vagal afferent signals in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, 320(2), G183-G192.
    DOI Scopus1 WoS1 Europe PMC1
    2021 Nunez-Salces, M., Li, H., Young, R. L., & Page, A. J. (2021). The secretion of total and acyl ghrelin from the mouse gastric mucosa: Role of nutrients and the lipid chemosensors FFAR4 and CD36. Peptides, 170673.
    DOI
    2021 Xie, C., Huang, W., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2021). Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease. Nutrients, 13(4), 1-16.
    DOI Scopus3 WoS4 Europe PMC2
    2020 Huang, W., Xie, C., Young, R. L., Zhao, J., Ebendorff-Heidepriem, H., Jones, K. L., . . . Wu, T. (2020). Development of innovative tools for investigation of nutrient-gut interaction. World Journal of Gastroenterology, 26(25), 3562-3576.
    DOI
    2020 Nunez-Salces, M., Li, H., Feinle-Bisset, C., Young, R. L., & Page, A. J. (2020). Nutrient-sensing components of the mouse stomach and the gastric ghrelin cell. Neurogastroenterology & Motility, 32(12), 1-13.
    DOI Scopus6 WoS3 Europe PMC3
    2019 Findeisen, M., Allen, T. L., Henstridge, D. C., Kammoun, H., Brandon, A. E., Baggio, L. L., . . . Febbraio, M. A. (2019). Treatment of type 2 diabetes with the designer cytokine IC7Fc. Nature, 574(7776), 63-68.
    DOI Scopus22 WoS20 Europe PMC12
    2019 Lumsden, A. L., Martin, A. M., Sun, E. W., Schober, G., Isaacs, N. J., Pezos, N., . . . Keating, D. J. (2019). Sugar responses of human enterochromaffin cells depend on gut region, sex, and body mass. Nutrients, 11(2), 1-13.
    DOI Scopus8 WoS9 Europe PMC5
    2019 Malbert, C. H., Horowitz, M., & Young, R. L. (2019). Low-calorie sweeteners augment tissue-specific insulin sensitivity in a large animal model of obesity. European Journal of Nuclear Medicine and Molecular Imaging, 46(11), 2380-2391.
    DOI Scopus4 WoS5 Europe PMC2
    2019 Sun, E. W., Martin, A. M., Wattchow, D. A., deFontgalland, D., Rabbitt, P., Hollington, P., . . . Keating, D. J. (2019). Metformin triggers PYY secretion in human gut mucosa. The Journal of clinical endocrinology and metabolism, 104(7), 2668-2674.
    DOI Scopus10 WoS11 Europe PMC3
    2019 Zhang, X., Young, R. L., Bound, M., Hu, S., Jones, K. L., Horowitz, M., . . . Wu, T. (2019). Comparative effects of proximal and distal small intestinal glucose exposure on glycemia, incretin hormone secretion, and the incretin effect in health and type 2 diabetes. Diabetes Care, 42(4), 520-528.
    DOI Scopus21 WoS18 Europe PMC12
    2019 Sun, E. W. L., Martin, A. M., Young, R. L., & Keating, D. J. (2019). The regulation of peripheral metabolism by gut-derived hormones. Frontiers in Endocrinology, 9(JAN), 1-11.
    DOI Scopus13 WoS20 Europe PMC11
    2018 Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018). Gut mechanisms linking intestinal sweet sensing to glycemic control. Frontiers in Endocrinology, 9, 741-1-741-11.
    DOI WoS14 Europe PMC5
    2018 Bahne, E., Sun, E. W., Young, R. L., Hansen, M., Sonne, D. P., Hansen, J. S., . . . Knop, F. K. (2018). Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes. JCI Insight, 3(23), e93936-1-e93936-15.
    DOI Scopus42 WoS42 Europe PMC17
    2018 Xie, C., Wang, X., Young, R. L., Horowitz, M., Rayner, C. K., & Wu, T. (2018). Role of intestinal bitter sensing in enteroendocrine hormone secretion and metabolic control. Frontiers in Endocrinology, 9, 576-1-576-10.
    DOI Scopus27 WoS25 Europe PMC10
    2018 Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889.
    DOI Scopus32 WoS30 Europe PMC15
    2018 Little, T. J., Cvijanovic, N., DiPatrizio, N. V., Argueta, D. A., Rayner, C. K., Feinle-Bisset, C., & Young, R. L. (2018). Plasma endocannabinoid levels in lean, overweight, and obese humans: relationships to intestinal permeability markers, inflammation, and incretin secretion. American Journal of Physiology: Endocrinology and Metabolism, 315(4), E489-E495.
    DOI Scopus18 WoS17 Europe PMC13
    2017 Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. International Journal of Obesity, 41(2), 233-239.
    DOI Scopus12 WoS11 Europe PMC9
    2017 Sun, E., De Fontgalland, D., Rabbitt, P., Hollington, P., Sposato, L., Due, S., . . . Keating, D. (2017). Mechanisms controlling glucose-induced GLP-1 secretion in human small intestine. Diabetes, 66(8), 2144-2149.
    DOI Scopus53 WoS57 Europe PMC28
    2017 Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans. Clinical Nutrition, 36(2), 1-6.
    DOI Scopus13 WoS12 Europe PMC11
    2017 Martin, A., Lumsden, A., Young, R., Jessup, C., Spencer, N., & Keating, D. (2017). The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. Neurogastroenterology and Motility, 29(6), e13046-1-e13046-8.
    DOI Scopus36 WoS32 Europe PMC12
    2017 Martin, A., Lumsden, A., Young, R., Jessup, C., Spencer, N., & Keating, D. (2017). Regional differences in nutrient-induced secretion of gut serotonin. Physiological Reports, 5(6), 1-12.
    DOI Scopus35 Europe PMC19
    2017 Martin, A., Young, R., Leong, L., Rogers, G., Spencer, N., Jessup, C., & Keating, D. (2017). The diverse metabolic roles of peripheral serotonin. Endocrinology, 158(5), 1049-1063.
    DOI Scopus82 WoS83 Europe PMC42
    2016 Rogers, G., Keating, D., Young, R., Wong, M., Licinio, J., & Wesselingh, S. (2016). From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Molecular Psychiatry, 21(6), 738-748.
    DOI Scopus354 WoS338 Europe PMC217
    2016 Lumsden, A., Young, R., Pezos, N., & Keating, D. (2016). Huntingtin-associated protein 1: eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. BMC Evolutionary Biology, 16(1), 214-1-214-18.
    DOI Scopus5 WoS6 Europe PMC3
    2015 Zelkas, L., Raghupathi, R., Lumsden, A., Martin, A., Sun, E., Spencer, N., . . . Keating, D. (2015). Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability. Nutrition and Metabolism, 12(1), 55.
    DOI Scopus26 WoS27 Europe PMC15
    2015 Reddi, B., Beltrame, J., Young, R., & Wilson, D. (2015). Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model. Intensive Care Medicine Experimental, 3(1), 36-1-36-15.
    DOI Europe PMC5
    2015 Symonds, E., Peiris, M., Page, A., Chia, B., Dogra, H., Masding, A., . . . Blackshaw, L. (2015). Mechanisms of activation of mouse and human enteroendocrine cells by nutrients. Gut, 64(4), 618-626.
    DOI Scopus62 WoS62 Europe PMC42
    2015 Cvijanovic, N., Feinle-Bisset, C., Young, R., & Little, T. (2015). Oral and intestinal sweet and fat tasting: impact of receptor polymorphisms and dietary modulation for metabolic disease. Nutition Reviews, 73(5), 318-334.
    DOI Scopus14 WoS13 Europe PMC8
    2015 Young, R. L., Lumsden, A. L., & Keating, D. J. (2015). Gut serotonin is a regulator of obesity and metabolism. Gastroenterology, 149(1), 253-255.
    DOI Scopus28 Europe PMC18
    2014 Nguyen, N., Debreceni, T., Bambrick, J., Chia, B., Wishart, J., Deane, A., . . . Young, R. (2014). Accelerated intestinal glucose absorption in morbidly obese humans: relationship to glucose transporters, incretin hormones, and glycaemia. Journal of Clinical Endocrinology and Metabolism, 100(3), 968-976.
    DOI Scopus57 WoS54 Europe PMC40
    2014 Thazhath, S., Wu, T., Young, R., Horowitz, M., & Rayner, C. (2014). Glucose absorption in small intestinal diseases. Expert Review of Gastroenterology and Hepatology, 8(3), 301-312.
    DOI Scopus13 WoS11 Europe PMC6
    2014 Nguyen, N., Debreceni, T., Bambrick, J., Chia, B., Deane, A., Wittert, G., . . . Young, R. (2014). Upregulation of intestinal glucose transporters after Roux-en-Y gastric bypass to prevent carbohydrate malabsorption. Obesity, 22(10), 2164-2171.
    DOI Scopus34 WoS33 Europe PMC26
    2014 Little, T., Isaacs, N., Young, R., Ott, R., Nguyen, N., Rayner, C., . . . Feinle-Bisset, C. (2014). Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(10), G958-G967.
    DOI Scopus32 WoS31 Europe PMC15
    2014 Deane, A., Rayner, C., Keeshan, A., Cvijanovic, N., Marino, Z., Nguyen, Q., . . . Young, R. (2014). The effects of critical illness on intestinal glucose sensing, transporters and absorption. Critical Care Medicine, 42(1), 57-65.
    DOI Scopus57 WoS57 Europe PMC35
    2013 Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T., . . . Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62(10), 3532-3541.
    DOI Scopus72 WoS67 Europe PMC48
    2013 Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A., . . . Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591(7), 1921-1934.
    DOI Scopus61 WoS60 Europe PMC41
    2013 Wu, T., Rayner, C., Young, R., & Horowitz, M. (2013). Gut motility and enteroendocrine secretion. Current Opinion in Pharmacology, 13(6), 928-934.
    DOI Scopus43 WoS42 Europe PMC27
    2013 Li, H., Kentish, S., Kritas, S., Young, R., Isaacs, N., O'Donnell, T., . . . Page, A. (2013). Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W. Acta Physiologica (Print Edition), 209(2), 179-191.
    DOI Scopus16 WoS17 Europe PMC8
    2013 Harrington, A., Brierley, S., Isaacs, N., Young, R., & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25(10), 660-668.
    DOI Scopus14 WoS12 Europe PMC8
    2013 Wu, T., Bound, M., Standfield, S., Bellon, M., Young, R., Jones, K., . . . Rayner, C. (2013). Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans. Diabetes Care, 36(12), e202-e203.
    DOI Scopus40 WoS43 Europe PMC25
    2012 Page, A., Symonds, E., Peiris, M., Blackshaw, L., & Young, R. (2012). Peripheral neural targets in obesity. British Journal of Pharmacology, 166(5), 1537-1558.
    DOI Scopus31 WoS30 Europe PMC22
    2012 Wu, T., Zhao, R., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2012). Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. American Journal of Clinical Nutrition, 95(1), 78-83.
    DOI Scopus107 WoS103 Europe PMC70
    2012 Kentish, S., Li, H., Philp, L., O'Donnell, T., Isaacs, N., Young, R., . . . Page, A. (2012). Diet-induced adaptation of vagal afferent function. Journal of Physiology-London, 590(1), 209-221.
    DOI Scopus91 WoS91 Europe PMC61
    2011 Blackshaw, L., Page, A., & Young, R. (2011). Metabotropic glutamate receptors as novel therapeutic targets on visceral sensory pathways. Frontiers in Neuroscience, 5(40), 1-7.
    DOI Scopus23 WoS24 Europe PMC22
    2011 Young, R. (2011). Sensing via intestinal sweet taste pathways. Frontiers in Neuroscience, 5(MAR), 23-1-23-13.
    DOI Scopus49 WoS44 Europe PMC31
    2011 Blackshaw, L., & Young, R. (2011). Detection and signaling of glucose in the intestinal mucosa - vagal pathway. Neurogastroenterology and Motility, 23(7), 591-594.
    DOI Scopus8 WoS7 Europe PMC7
    2010 Young, R., Page, A., Isaacs, N., Flach, C., & Blackshaw, L. (2010). Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves. Gastroenterology, 138(3), 1091-1106.
    DOI Scopus42 WoS27 Europe PMC19
    2010 Ma, J., Chang, J., Checklin, H., Young, R., Jones, K., Horowitz, M., & Rayner, C. (2010). Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects. British Journal of Nutrition, 104(6), 803-806.
    DOI Scopus98 WoS90 Europe PMC71
    2010 Ma, J., Bellon, M., Wishart, J., Young, R., Jones, K., Horowitz, M., & Rayner, C. (2010). Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans. Regulatory Peptides, 159(1-3), 156-159.
    DOI Scopus5 WoS4 Europe PMC2
    2010 Isaacs, N. J., Young, R. L., Wittert, G., Blackshaw, L. A., & Page, A. J. (2010). Anatomy of gastric vagal afferent innervation in normal and obese mice. NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9.
    2009 Young, R., Sutherland, K., Pezos, N., Brierley, S., Horowitz, M., Rayner, C., & Blackshaw, L. (2009). Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut, 2008(3), 337-346.
    DOI Scopus139 WoS139 Europe PMC97
    2009 Ma, J., Bellon, M., Wishart, J., Young, R., Blackshaw, L., Jones, K., . . . Rayner, C. (2009). Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American Journal of Physiology-Gastrointestinal and Liver Physiology, 296(4), G735-G739.
    DOI Scopus182 WoS171 Europe PMC120
    2009 Page, A., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2009). Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function. Journal of Neuroscience, 29(22), 7246-7255.
    DOI Scopus31 WoS30 Europe PMC24
    2008 Young, R., Isaacs, N., & Blackshaw, L. (2008). Chemical coding and central projections of gastric vagal afferent neurons. Neurogastroenterology and Motility, 20(6), 708-718.
    DOI Scopus28 WoS23 Europe PMC18
    2008 Young, R., Isaacs, N., & Blackshaw, L. (2008). Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways. Neuropharmacology, 54(6), 965-975.
    DOI Scopus23 WoS21 Europe PMC15
    2007 Sutherland, K., Young, R., Isaacs, N., Horowitz, M., & Blackshaw, L. (2007). Phenotypic characterization of taste cells of the mouse small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(5), G1420-G1428.
    DOI Scopus106 WoS105 Europe PMC81
    2007 Hughes, P., Brierley, S., Young, R., & Blackshaw, L. (2007). Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Journal of Comparative Neurology, 500(5), 863-875.
    DOI Scopus78 WoS70 Europe PMC64
    2007 Young, R., Page, A., Isaacs, N., O'Donnell, T., & Blackshaw, L. (2007). Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G501-G511.
    DOI Scopus37 WoS31 Europe PMC27
    2005 Page, A., Young, R., Martin, C., Umaerus, M., O'Donnell, T., Isaacs, N., . . . Blackshaw, L. (2005). Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology, 128(2), 402-410.
    DOI Scopus81 WoS69 Europe PMC60
    2005 Page, A., Slattery, J., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2005). Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret. Journal of Physiology-London, 563(3), 809-819.
    DOI Scopus28 WoS24 Europe PMC19
    2001 Partosoedarso, E., Young, R., & Blackshaw, L. (2001). GABAB receptors on vagal afferent pathways: peripheral and central inhibition. American Journal of Physiology-Gastrointestinal and Liver Physiology, 280(4), G658-G668.
    DOI Scopus68 WoS60 Europe PMC43
    2001 Smid, S., Young, R., Isaacs, N., & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281(6), G1494-G1501.
    DOI Scopus61 WoS46 Europe PMC33
    2001 Sakaguchi, G., Young, R., Komeda, M., Yamanaka, K., Buxton, B., & Louis, W. (2001). Left ventricular aneurysm repair in rats: Structural, functional, and molecular consequences. Journal of Thoracic and Cardiovascular Surgery, 121(4), 750-761.
    DOI Scopus12 WoS10 Europe PMC5
    1998 Young, R. L., Gundlach, A. L., & Louis, W. J. (1998). Altered cardiac hormone and contractile protein messenger RNA levels following left ventricular myocardial infarction in the rat: An in situ hybridization histochemical study. Cardiovascular Research, 37(1), 187-201.
    DOI Scopus10 WoS10 Europe PMC7
    1993 Young, R., Jonsson, J., Mano, M., Frewin, D., & Head, R. (1993). Influence of α<inf>1</inf>and α<inf>2</inf>-adrenoceptor antagonist therapy on the development of hypertension in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 21(5), 780-790.
    DOI Scopus3 WoS5 Europe PMC3

  • Book Chapters
    Year Citation
    2019 Martin, A., Young, R., Leong, L., Rogers, G., Spencer, N., Jessup, C., & Keating, D. (2019). Cellular regulation of peripheral serotonin. In P. M. Pilowsky (Ed.), Serotonin: The Mediator that Spans Evolution (pp. 137-153). London, United Kingdom: Academic Press.
    DOI

  • Conference Papers
    Year Citation
    2018 Nam, Q. N., Naidu, J., Debricini, T., Burgess, J., Safaeian, R., Young, R., & Horowitz, M. (2018). Is dysregulation of intestinal glucose transporters in the morbidly obese responsible for the development of diabetes mellitus?. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 (pp. 218-219). WILEY.
    2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, I., Nguyen, N. Q., . . . Brierley, S. M. (2014). Distinct Alterations in the Guanylate Cyclase-C (GC-C)/Cyclic GMP (cGMP) Pathway Are Evident Across Different Subtypes of Irritable Bowel Syndrome (IBS) Patients. In GASTROENTEROLOGY Vol. 146 (pp. S537). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
    WoS3
    2014 Nguyen, N. Q., Debreceni, T. L., Bambrick, J. E., Chia, B., Wishart, J. M., Deane, A. M., . . . Young, R. L. (2014). Accelerated Glucose Absorption in Proximal Intestine and Its Relationship to Glucose Transporters, Incretin Hormones and Glycaemia in Morbidly Obese Humans: the "X-Factor" of the Foregut Theory?. In GASTROENTEROLOGY Vol. 146 (pp. S108). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
    2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, A., Nguyen, N. Q., . . . Brierley, S. M. (2013). Alterations in the Guanylate Cyclase-C/cGMP Pathway in Patients With Irritable Bowel Syndrome With Constipation. In GASTROENTEROLOGY Vol. 144 (pp. S59-S60). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
    2013 Nguyen, N. Q., Debreceni, T. L., Chia, B., Burgstad, C. M., Neo, M., Deane, A. M., . . . Young, R. L. (2013). Intestinal Sweet Taste Receptor and Transporter Expression, Post-Prandial Glycemia and Glucose Absorption in Morbidly Obese Subjects. In GASTROENTEROLOGY Vol. 144 (pp. S836). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
    2011 Little, T., Young, R., Blackshaw, L., Rayner, C., & Feinle-Bisset, C. (2011). Expression of the fatty acid sensors, CD36, GPR119 and GPR120, in the duodenum of humans. Relationships with obesity. In 19th Annual Meeting of the Society for the Study of Ingestive Behavior Vol. 575 (pp. S26). Netherlands: Elsevier BV.
    DOI
    2011 Young, R. L., Deane, A. M., Chia, B., Horowitz, M., Blackshaw, L. A., & Rayner, C. (2011). Dysregulation of Intestinal Glucose Transporter and Sweet Taste Receptor Expression in Critical Illness. In GASTROENTEROLOGY Vol. 140 (pp. S194). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
    2011 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. In DIABETOLOGIA Vol. 54 (pp. S330). Lisbon, PORTUGAL: SPRINGER.
    2010 Harrington, A., Young, R., Brierley, S., & Blackshaw, L. (2010). TRPV1 mediates acid activation of esophageal sensory pathways. In Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting, NGM 2010 Vol. 22 (pp. 55). UK: Wiley-Blackwell Publishing Ltd.
    2010 Isaacs, N., Flach, C., Young, R., Wittert, G., Blackshaw, L., & Page, A. (2010). Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice. In Proceedings Vol. 138 (pp. 0 pages). USA: W.B. Saunders Co..
    DOI
    2007 Pezos, N., Sutherland, K., Brierley, S. M., Horowitz, M., Blackshaw, L. A., & Young, R. L. (2007). Vagal afferents do not directly detect intestinal glucose via a sweet-taste mechanism. In GASTROENTEROLOGY Vol. 132 (pp. A587). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
    2006 Sutherland, K., Cooper, N. J., Horowitz, M., Margolskee, R. F., Blackshaw, L. A., & Young, R. L. (2006). Taste receptor G-protein alpha-gustducin does not colocalise with enteroendocrine cell markers in the mouse intestine. In GASTROENTEROLOGY Vol. 130 (pp. A605). Los Angeles, CA: W B SAUNDERS CO-ELSEVIER INC.
    2005 Gountounas, N., Cooper, N., Horowitz, M., Margolskee, R., Blackshaw, L., & Young, R. (2005). Does the gut 'taste' sweet? Identifying glucosensor molecules in the small intestine. In GASTROENTEROLOGY Vol. 128 (pp. A555). Chicago, IL: W B SAUNDERS CO.
    2002 Young, R., Cooper, N., & Blackshaw, L. (2002). Neurochemical coding of gastric vago-vagal pathways in the ferret. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS.

  • Conference Items
    Year Citation
    2020 Li, H., Christie, S., Clarke, G., Watson, O., Young, R., Gatford, K., & Page, A. (2020). Gastric vagal afferent satiety signals are attenuated during pregnancy. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
    2020 Xie, C., Wang, X., Bound, M. J., Young, R. L., Jones, K. L., Horowitz, M., . . . Wu, T. (2020). Bitter taste signalling modulates bile acid-induced PYY, but not GLP-1 secretion in healthy humans. Poster session presented at the meeting of Abstracts of the 56th Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Virtual Online: Springer-Verlag.
    DOI
    2020 Nunez-Salces, M., Li, H., Young, R. L., Feinle-Bisset, C., & Page, A. J. (2020). Nutrient-sensing mechanisms of the gastric ghrelin cell. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
    2020 Kreuch, D., Ivey, K., Mobegi, F. M., Leong, L., Isaacs, N. J., Pezos, N., . . . Young, R. L. (2020). Mechanisms linking low-calorie sweeteners to impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 4th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2020), as published in Neurogastroenterology and Motility. Adelaide Convention Centre, Adelaide, Australia: Wiley.
    DOI
    2018 Young, R., Kreuch, D., Mobegi, F., Leong, L., Schober, G., Isaacs, N., . . . Rogers, G. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI
    2018 Xie, C., Wang, X., Bound, M., Grivell, J., Young, R., Jones, K., . . . Wu, T. (2018). Effects of the bitter taste receptor agonist, denatonium benzoate, on postprandial glycaemia, gastric emptying and energy intake in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI
    2017 Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI WoS2
    2015 Nguyen, N., Burgess, J., Debrecini, T., Wishart, J., Rayner, C., Horowitz, M., & Young, R. (2015). Impact of a 2-week very low calorie diet (vlcd) on fatty acid sensing and transport, incretin hormones and lipid profile in morbidly obese humans. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY-BLACKWELL.
    2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2014). Distinct alterations in the guanylate cyclase-C/cGMP pathway are evident across different subtypes of irritable bowel syndrome patients. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
    DOI
    2013 Namq, N., Debreceni, T., Chia, B., Burgstad, C., Neo, M., Deane, A., . . . Young, R. (2013). Abnormal intestinal glucose transport & absorption in obesity: implication in weight gain & diabetes. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Shanghai, China: Wiley-Blackwell.
    2013 Nguyen, N. Q., Debreceni, T. L., Chia, B., Burgstad, C. M., Neo, M., Wittert, G. A., . . . Young, R. L. (2013). Alterations in the expression of intestinal sweet taste receptor and glucose transporters after Roux-en-Y gastric bypass: an adaptive response to prevent carbohydrate malabsorption. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY.
    2013 Namq, N., Debreceni, T., Chia, B., Burgstad, C., Neo, M., Wittert, G., . . . Young, R. (2013). Upregulation of intestinal glucose transporters after RYGB prevents carbohydrate. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY.
    2013 Nguyen, N. Q., Debreceni, T. L., Chia, B., Burgstad, C. M., Neo, M., Deane, A. M., . . . Young, R. L. (2013). Dysregulation of intestinal glucose absorption and glucose transporters in morbidly obesity: potential molecular mechanisms of weight gain and diabetes in obesity. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Melbourne, Vic.: Wiley.
    DOI
    2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2013). The guanylatecyclase-c/CGMP pathway is altered in patients with irritable bowel syndrome with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
    DOI
    2010 Young, R., Sutherland, K., Pezos, N., Brierley, S., Ma, J., Rayner, C., . . . Blackshaw, L. (2010). Control of intestinal sweet taste receptor expression is impaired in type 2 diabetes. Poster session presented at the meeting of Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting (NGM), as published in Neurogastroenterology & Motility. Boston, MA, USA: Wiley-Blackwell Publishing.
    DOI WoS2

NHMRC

  • 2020-23 Ideas (APP1181145) Young RL, Ivey KL. 'Friend or Foe? Low-calorie sweeteners and glycaemic control in type 2 diabetes'
  • 2019-21 Project (APP1164475) Keating DJ, Young RL,  Holst JJ, Knop FK. 'Targeting proglucagon cells in the human gut to treat diabetes and obesity'
  • 2018-20 Project (APP1147333) Wu T, Rayner CK, Jones KL, Young RL,  Feinle-Bisset C. 'Bitter taste as a mediator of food intake and postprandial glycaemia in health and type 2 diabetes'
  • 2014-18 Project (APP1081182) Young RL, Rayner CK, Horowitz M ‘Why do sweetened drinks link to type 2 diabetes?’
  • 2010-12 Project (APP627127) Young RL 'Glucose detection pathways in the gut'

Australian Research Council

  • 2015-18 ARC Linkage (LP150100419) Keating DM, Young RL, Liou A, Jackson VM ‘Mechanisms controlling enteroendocrine hormone secretion in human duodenum’

Diabetes Australia

  • 2021 Research Grant. Young RL, Rayner CK, Horowitz M, Wu T, Rogers GB, Ivey KL. 'Blocking intestinal sweet taste for glycaemic benefits in type 2 diabetes'
  • 2020 Research Grant. Young RL, Rogers GB, Rayner CK, Horowitz M, Wu T. 'Does the gut microbiome link intake of low-calorie sweeteners to impaired blood glucose control?'
  • 2018-19 Millennium Award, Type 2 Diabetes. Young RL, Rayner CK, Horowitz M, Wu T. 'Do artificial sweeteners affect glycaemic control adversely in people with type 2 diabetes?'
  • 2013 Research Grant. Young RL, Rayner CK, Blackshaw LA, Horowitz M. 'Postprandial consequences of intestinal sweet taste receptor dysregulation in type 2 diabetes'
  • 2008 Research Grant. Young RL, Rayner CK, Blackshaw LA, Horowitz M. 'Characterisation of intestinal sweet-taste molecules in type-2 diabetes'

The Hospital Research Foundation

  • 2018-20 (Translational Research) Young RL, Rayner CK, Rogers GB. 'A bitter tale of artificial sweeteners in Type 2 diabetes?'

Diabetes SA

  • 2018-19 (Project, Inaugural Round) Young RL, Rayner CK, Rogers GB, Horowitz M. 'A bitter tale of artificial sweeteners in human health and Type 2 diabetes?'

Royal Adelaide Hospital

  • 2018 Clinical Project (9747) Young RL, Nguyen NQ, Rayner CK, Wu T, Horowitz M. 'Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes'
  • 2016 Clinical Project (2155) Wong S, Young RL, Nguyen NQ, Rayner CK. 'Impact of blocking intestinal glucose transporter 2 (GLUT2) on glucose absorption, glycaemic control and incretin responses in morbidly obese subjects with type 2 diabetes mellitus'
  • 2014-16 Clinical Project (1772) Young RL, Wu T, Rayner CK. 'Intestinal sweet taste receptor control of glucose absorption in human health and type 2 diabetes'

  • 2013-14 Clinical Project (1483) Young RL, Rayner CK, Nguyen N. 'Molecular determinants of glucose sensing in human gastrointestinal tract'

  • 2012 Clinical Project (7849) Young RL, Deane AM. 'Protein determinants of intestinal carbohydrate malabsorption in critical illness'

  • 2012 Clinical Project Symonds E, Young RL, Nguyen N. 'Evaluation of nutrient sensing in the large intestine and modulation by obesity

MedVet Laboratories

  •  2011 (Special Research Project) Deane AM, Young RL. 'The intestinal glucose transporter SGLT-1 as a novel therapeutic target in critical illness'

Intensive Care Foundation Australia

  • 2014 (Research Grant) Young RL, Deane AM. 'Intestinal GLP-2 as a novel target in critical illness-induced malabsorption'

  • 2011 (Research Grant) Deane AM, Young RL, Chapman MJ, Rayner CK, Horowitz M. 'Critical illness & intestinal sweet taste receptors'

    Expand

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2020 Principal Supervisor Mechanisms linking low-calorie sweeteners to impaired glycaemic control in human health and type 2 diabetes. Doctor of Philosophy Doctorate Full Time Mr Braden David Rose
    2020 Co-Supervisor Adaptations to gastrointestinal nutrient absorption during pregnancy Doctor of Philosophy Doctorate Full Time Mr Teunis Sebastian Overduin
    2019 Principal Supervisor Gut mechanisms linking artificial sweeteners to impaired glycaemic control Doctor of Philosophy Doctorate Part Time Miss Denise Kreuch

  • Past Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2012 - 2017 Principal Supervisor Gastrointestinal Nutrient Sensing in Obesity and type 2 Diabetes: Role in Appetite Regulation and Glycaemic Control Doctor of Philosophy Doctorate Full Time Ms Nada Cvijanovic
    2004 - 2009 Co-Supervisor Nutrient Sensing Mechanisms in the Small Intestine: Localisation of Taste Molecules in Mice and Humans With and Without Diabetes Doctor of Philosophy Doctorate Full Time Ms Kate Sutherland

  • Other Supervision Activities
    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2014 - ongoing External Supervisor Isolation, purification and characterisation of human enteroendocrine cells Flinders University of South Australia School of Medicine, PhD Doctorate Full Time Emily Wai-Ling Sun
  • Position: Head of Intestinal Nutrient Sensing Group
  • Phone: 81284845
  • Email: richard.young@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI - South, floor 7
  • Room: 7
  • Org Unit: Medical Specialties
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