Dr Peter Zalewski
Senior Lecturer - Level C
School of Medicine
College of Health
My main interest currently is the role of labile zinc in cardiovascular physiology and disease. I co-discovered labile zinc and its role in cell signalling in the 1990s. The zinc fluorophore our group developed in 1990s is used around the world by researchers. I have more than 90 publications on zinc. I have been involved on a wide range of committees at the University of Adelaide and Basil Hetzel Institute for Translational Health Research. I have extensive experience as a post graduate coordinator in Medicine and am currently an Honours Coordinator for Medicine in the Adelaide Medical School.
Dr Zalewski is a Post-doctoral fellow Level C in the Adelaide Medical School at the University of Adelaide. He heads the Zinc Biology Research Laboratory at the Basil Hetzel Institute for Translational Health Research. He has had a major interest in the cellular biology of Zn and particularly, the development of techniques to visualize and quantify the more dynamic, labile pools of Zn and their role in the regulation of apoptosis. In 1996, he was awarded an NHMRC grant to develop zinc fluorophores that would enable measurement of labile Zn in normal and diseased cells and tissue. The prototype Zinquin is used around the world to study cellular biology of Zn, although several types of zinc fluorophores are also now available. He has also developed a rapid and sensitive fluorescence-based assay that allows measurement of labile Zn in body fluids, as a potentially more relevant biomarker of zinc status than total plasma zinc. This test was adapted to measure zinc in sputum and bronchoalveolar lavage. His group was the first to identify the link between labile cellular zinc and suppression of apoptosis (1993). They were also were the first to describe the release of Zn from metalloproteins in apoptotic cells (in 1994), featuring on the cover of the journal, and the rapid activation of procaspase-3 in Zn-deficient cells (1999). He chaired the session “Zinc and control of cell death” for the 1st, 3rd and 5th International Conferences on Zn Signalling held in Grand Cayman, Aarhus and Jerusalem. In February 2007, he was invited to a workshop in Bangladesh under the auspices of Harvest Plus (New York) to participate in the planning of a trial of Zn fortified rice with the aim of reducing childhood mortality due to diarrhea, where he advised on methods of assessing Zn deficiency in these children and measuring outcomes of the trial. Between 2004 and 2010, he was awarded three NHMRC project grants as CIA to study Zn in the airway epithelium and techniques to monitor it in asthmatic patients. His group was the first to image zinc in the airway tissue showing that the respiratory tract (from nasal epithelium through to bronchiolar epithelium) contains a rich lining of labile zinc. Removal of this zinc in isolated airway epithelial cells rendered them highly vulnerable to noxious agents, including oxidants. His group then showed depletion of this zinc in a murine model of allergic airway inflammation and significantly decreased zinc in the induced sputum of asthmatics. In the mouse model, there was a strong association between low dietary Zn intake and severity of airway epithelial cell death, airway inflammation and bronchial hyper-responsiveness to methacholine. He was invited to review this field of research for Current Opinions In Pharmacology. In 2010, a productive collaboration with Prof Sandy Hodge enabled the first measurements of Zn and its specific transporter proteins in alveolar macrophages (AM) in the context of long-term smoking and COPD. Declines in BAL Zn in long-term smokers with COPD were shown. This may, in part, contribute to the impaired phagocytic ability for AM from COPD subjects, as positive associations were found between Zn levels and AM phagocytic ability. Currently, he is a co-chief investigator with Prof Hodge on an NHMRC grant (2016-18) looking at autophagy in COPD. Recent productive collaborations have been with an islet transplant consortium (Prof Toby Coates) and CSIRO (Prof Michael Fenech). In 2011, he was invited to write a chapter on zinc in cell proliferation and cell death for a new book on zinc in human health. In 2013 he commenced a collaboration with a vascular research group led by Prof John Beltrame providing an opportunity to extend the work of zinc in the airways to blood vessels. This led to the establishment of the arterial endothelial "biopsy" technique and its use to study zinc-related biology in ex-vivo arterial endothelial cells from patients. This resulted in a successful NHMRC grant 2018-2021 as CIA. His current research interests are zinc deficiency, vasoconstriction, vasospasm and coronary heart disease.
| Date | Position | Institution name |
|---|---|---|
| 2018 - ongoing | Health and Medical Sciences Honours Coordinator Medicine & Specialities | University of Adelaide |
| 2014 - 2018 | Postgraduate Coordinator Medicine (TQEH) | University of Adelaide |
| 2010 - ongoing | Senior Lecturer | University of Adelaide |
| 2002 - 2002 | Visiting Professor | Institute of Anatomy |
| 1997 - 2009 | Research Fellow/ Lecturer B | University of Adelaide |
| 1989 - ongoing | Visiting Sicnetist | National Jewish Centre for Immunology and Pediatrics |
| 1978 - ongoing | Visiting Scientist | Institut Fur Immunologie und Serologie, Heidelberg |
| 1976 - 1997 | Research Officer | University of Adelaide |
| 1975 - 1976 | Research Assistant | University of Adelaide |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1990 | University of Adelaide | Australia | PhD |
| 1976 | University of Adelaide | Australia | BSc (Hons) |
| Year | Citation |
|---|---|
| 2022 | Tran, H. B., Jakobczak, R., Abdo, A., Asare, P., Reynolds, P., Beltrame, J., . . . Zalewski, P. (2022). Immunolocalization of zinc transporters and metallothioneins reveals links to microvascular morphology and functions. Histochemistry and Cell Biology, 158(5), 485-496. Scopus9 WoS7 Europe PMC8 |
| 2021 | Tran, H. B., Maiolo, S., Harper, R., Zalewski, P. D., Reynolds, P., & Hodge, S. (2021). Dysregulated zinc and sphingosine-1-phosphate signalling in pulmonary hypertension: potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels. Cell Biology International, 45(11), 2368-2379. Scopus10 WoS10 Europe PMC10 |
| 2021 | Abdo, A. I., Tran, H. B., Hodge, S., Beltrame, J. F., & Zalewski, P. D. (2021). Zinc homeostasis alters zinc transporter protein expression in vascular endothelial and smooth muscle cells. Biological Trace Element Research, 199(6), 1-14. Scopus22 WoS19 Europe PMC20 |
| 2021 | Zalewski, P. D., Tvorogova, Z., Abdo, A., Wawer, A. A., Hodge, S., Murgia, C., . . . Beltrame, J. F. (2021). Harvesting endothelial cells during routine invasive coronary procedures. Journal of the American College of Cardiology, 77(24), 3136-3138. |
| 2018 | Zalewski, P. D., Beltrame, J. F., Wawer, A. A., Abdo, A. I., & Murgia, C. (2018). Roles for endothelial zinc homeostasis in vascular physiology and coronary artery disease. Critical Reviews in Food Science and Nutrition, 59(21), 3511-3525. Scopus41 WoS36 Europe PMC30 |
| 2017 | Roscioli, E., Jersmann, H., Lester, S., Badiei, A., Fon, A., Zalewski, P., & Hodge, S. (2017). Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD. International Journal of Chronic Obstructive Pulmonary Disease, 12, 3503-3510. Scopus44 WoS40 Europe PMC36 |
| 2017 | Roscioli, E., Tran, H., Jersmann, H., Nguyen, P., Hopkins, E., Lester, S., . . . Hodge, S. (2017). The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD. American Journal of Physiology - Lung Cellular and Molecular Physiology, 313(3), L453-L465. Scopus32 WoS29 Europe PMC26 |
| 2017 | Nossent, J., Lester, S., Rischmueller, M., & Zalewski, P. (2017). No zinc deficiency but a putative immunosuppressive role for labile Zn in patients with systemic autoimmune disease. Current Rheumatology Reviews, 13(1), 59-64. Scopus4 WoS4 Europe PMC3 |
| 2017 | Roscioli, E., Hamon, R., Ruffin, R., Grant, J., Hodge, S., Zalewski, P., & Lester, S. (2017). BIRC3 single nucleotide polymorphism associate with asthma susceptibility and the abundance of eosinophils and neutrophils. Journal of Asthma, 54(2), 116-124. Scopus12 WoS12 Europe PMC11 |
| 2015 | Sharif, R., Thomas, P., Zalewski, P., & Fenech, M. (2015). Zinc supplementation influences genomic stability biomarkers, antioxidant activity and zinc transporter genes in an elderly Australian population with low zinc status. Molecular Nutrition & Food Research, 59(6), 1200-1212. Scopus60 WoS52 Europe PMC44 |
| 2014 | Hamon, R., Homan, C., Tran, H., Mukaro, V., Lester, S., Roscioli, E., . . . Hodge, S. (2014). Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD. PLoS ONE, 9(10), e110056-1-e110056-9. Scopus58 WoS58 Europe PMC49 |
| 2013 | Roscioli, E., Hamon, R., Ruffin, R., Lester, S., & Zalewski, P. (2013). Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines. Physiological Reports, 1(5), e00123-1-e00123-11. Scopus13 WoS13 Europe PMC9 |
| 2013 | Jardeleza, C., Miljkovic, D., Baker, L., Boase, S., Tan, N., Koblar, S., . . . Vreugde, S. (2013). Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Rhinology, 51(4), 315-322. Scopus14 WoS12 Europe PMC11 |
| 2013 | Roscioli, E., Hamon, R., Lester, S., Murgia, C., Grant, J., & Zalewski, P. (2013). Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways. Biometals, 26(2), 205-227. Scopus19 WoS15 Europe PMC13 |
| 2013 | Ranadli, G., Ferruzza, S., Canali, R., Leoni, G., Zalewski, P., Sambuy, Y., . . . Murgia, C. (2013). Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα. Journal of Nutritional Biochemistry, 24(6), 967-976. Scopus49 WoS46 Europe PMC38 |
| 2013 | Roscioli, E., Hamon, R., Ruffin, R., Zalewski, P., Grant, J., & Lester, S. (2013). X-linked inhibitor of apoptosis single nucleotide polymorphisms and copy number variation are not risk factors for asthma. Respirology, 18(4), 697-703. Scopus5 WoS5 Europe PMC3 |
| 2013 | Jardeleza, C., Miljkovic, D., Baker, L., Boase, S., Tan, N. C. W., Koblar, S. A., . . . Vreugde, S. (2013). Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Rhinology journal, 51(4), 315-322. |
| 2012 | Tran, H., Lewis, M., Tan, L. W., Lester, S., Baker, L., Ng, J., . . . Lang, C. (2012). Immunolocalization of NLRP3 inflammasome in normal murine airway epithelium and changes following induction of ovalbumin-induced airway inflammation. Journal of Allergy, Online(819176), 1-13. Europe PMC43 |
| 2012 | Lester, S., Rischmueller, M., Tan, L., Wormald, P., Zalewski, P., Hamilton-Bruce, M., . . . Hill, C. (2012). Sicca symptoms and their association with chronic rhinosinusitis in a community sample. The Open Rheumatology Journal, 6(1), 170-174. Scopus8 Europe PMC6 |
| 2012 | Sharif, R., Thomas, P., Zalewski, P., & Fenech, M. (2012). The role of zinc in genomic stability. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 733(1-2), 111-121. Scopus138 WoS121 Europe PMC91 |
| 2012 | Sharif, R., Thomas, P., Zalewski, P., & Fenech, M. (2012). Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells. Genes & Nutrition, 7(2), 139-154. Scopus44 WoS37 Europe PMC27 |
| 2011 | Bosco, M., Mohanasundaram, D., Drogemuller, C., Lang, C., Zalewski, P., & Coates, P. (2011). Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation. The Review of Diabetic Studies, 7(4), 263-274. Scopus32 Europe PMC24 |
| 2011 | Murgia, C., Grosser, D., TruongTran, A., Roscioli, E., Michalczyk, A., Ackland, M., . . . Zalewski, P. (2011). Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation. Nutrients, 3(11), 910-928. Scopus24 WoS22 Europe PMC18 |
| 2011 | Mohanasundaram, D., Drogemuller, C., Brealey, J., Jessup, C., Milner, C., Murgia, C., . . . Coates, P. (2011). Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in new world primate (Callithrix jacchus) and human pancreatic islets. General and Comparative Endocrinology, 174(2), 71-79. Scopus23 WoS23 Europe PMC17 |
| 2011 | Sharif, R., Thomas, P., Zalewski, P., Graham, R., & Fenech, M. (2011). The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 720(1-2), 22-33. Scopus42 WoS38 Europe PMC31 |
| 2011 | Jayaram, L., Chunilal, S., Pickering, S., Ruffin, R., & Zalewski, P. (2011). Sputum zinc concentration and clinical outcome in older asthmatics. Respirology, 16(3), 459-466. Scopus23 WoS24 Europe PMC21 |
| 2011 | Lang, C., Hansen, M., Roscioli, E., Jones, J., Murgia, C., Ackland, M., . . . Ruffin, R. (2011). Dietary zinc mediates inflammation and protects against wasting and metabolic derangement caused by sustained cigarette smoke exposure in mice. Biometals, 24(1), 23-39. Scopus20 WoS19 Europe PMC15 |
| 2011 | Tran, H., Rischmueller, M., Lester, S., Tan, L., Lewis, M., Koblar, S., . . . Zalewski, P. (2011). INFLAMMASOME ACTIVATION IS IMPLICATED IN DISEASE PATHOGENESIS IN ASTHMA AND PRIMARY SJOGREN'S SYNDROME. INTERNAL MEDICINE JOURNAL, 41, 9. |
| 2011 | Jayaram, L., & Zalewski, P. D. (2011). The clinical relevance of zinc in respiratory (mainly airway) disease management. Treatment Strategies - Respiratory, 1(1), 15-21. |
| 2009 | Murgia, C., Devirgiliis, C., Mancini, E., Donadel, G., Zalewski, P., & Perozzi, G. (2009). Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands. Nutrition Metabolism and Cardiovascular Diseases, 19(6), 431-439. Scopus84 WoS82 Europe PMC72 |
| 2008 | Zalewski, P., & Ruffin, R. (2008). Apoptosis-regulatory factors as potential drug targets in the epithelium of normal and inflamed airways. Current Molecular Pharmacology, 1(1), 38-49. Scopus14 Europe PMC10 |
| 2007 | Devirgiliis, C., Zalewski, P., Perozzi, G., & Murgia, C. (2007). Zinc fluxes and zinc transporter genes in chronic diseases. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 622(1-2), 84-93. Scopus132 WoS125 Europe PMC97 |
| 2007 | Lang, C., Murgia, C., Leong, M., Tan, L., Perozzi, G., Knight, D., . . . Zalewski, P. (2007). Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology, 292(2), L577-L584. Scopus143 WoS128 Europe PMC93 |
| 2006 | Zalewski, P. (2006). Zinc metabolism in the airway: basic mechanisms and drug targets. Current Opinion in Pharmacology, 6(3), 237-243. Scopus51 WoS47 Europe PMC42 |
| 2006 | Murgia, C., Lang, C., TruongTran, A., Grosser, D., Jayaram, L., Ruffin, R., . . . Zalewski, P. (2006). Zinc and its specific transporters as potential targets in airway disease. Current Drug Targets, 7(5), 607-627. Scopus36 WoS35 Europe PMC34 |
| 2006 | Zalewski, P., TruongTran, A., Lincoln, S., Ward, A., Shankar, A., Coyle, P., . . . Ruffin, R. (2006). Use of a zinc fluorophore to measure labile pools of zinc in body fluids and cell-conditioned media. Biotechniques, 40(4), 509-520. Scopus59 WoS55 Europe PMC43 |
| 2005 | Zalewski, P., TruongTran, A., Grosser, D., Jayaram, L., Murgia, C., & Ruffin, R. (2005). Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review. Pharmacology & Therapeutics, 105(2), 127-149. Scopus171 WoS159 Europe PMC115 |
| 2005 | Tudor, R., Zalewski, P., & Ratnaike, R. (2005). Zinc in health and chronic disease. Journal of Nutrition, Health and Aging, 9(1), 45-51. Scopus69 WoS64 Europe PMC44 |
| 2004 | Milton, A., Zalewski, P., & Ratnaike, R. (2004). Zinc protects against arsenic induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity. Biometals, 17(6), 707-713. Scopus36 WoS30 Europe PMC27 |
| 2004 | Ho, L., Ruffin, R., Murgia, C., Li, L., Krilis, S., & Zalewski, P. (2004). Labile zinc and zinc transporter ZnT4 in mast cell granules: Role in regulation of caspase activation and NF-KB translocation. Journal of Immunology, 172(12), 7750-7760. Scopus78 WoS72 Europe PMC61 |
| 2003 | TruongTran, A., Grosser, D., Ruffin, R., Murgia, C., & Zalewski, P. (2003). Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation. Biochemical Pharmacology, 66(8), 1459-1468. Scopus101 WoS94 Europe PMC87 |
| 2002 | Carter, J., TruongTran, A., Grosser, D., Ho, L., Ruffin, R., & Zalewski, P. (2002). Involvement of redox events in caspase activation in zinc-depleted airway epithelial cells. Biochemical and Biophysical Research Communications, 297(4), 1062-1070. Scopus55 WoS49 Europe PMC43 |
| 2002 | TruongTran, A., Ruffin, R., Foster, P., Koskinen, A., Coyle, P., Philcox, J., . . . Zalewski, P. (2002). Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation. American Journal of Respiratory Cell and Molecular Biology, 27(3), 286-296. Scopus77 WoS68 Europe PMC60 |
| 2002 | Ranaldi, G., Perozzi, G., Truong-Tran, A., Zalewski, P., & Murgia, C. (2002). Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells. American Journal of Physiology Renal Physiology, 283(6 52-6), F1365-F1375. Scopus40 WoS38 Europe PMC25 |
| 2001 | Truong-Tran, A., Ruffin, R., & Zalewski, P. (2001). Apical cytoplasmic zinc inhibits caspase-activated apoptosis in respiratory epithelial cells. Respirology, 6(SUPPL. 1), A3. |
| 2001 | Truong-Tran, A. Q., Carter, J., Ruffin, R. E., & Zalewski, P. D. (2001). The role of zinc in caspase activation and apoptotic cell death. Biometals, 14(3-4), 315-330. Scopus400 WoS402 Europe PMC272 |
| 2001 | TruongTran, A., Carter, J., Ruffin, R., & Zalewski, P. (2001). New insights into the role of zinc in the respiratory epithelium. Immunology and Cell Biology, 79(2), 170-177. Scopus133 WoS123 Europe PMC97 |
| 2000 | TruongTran, A., Ruffin, R., & Zalewski, P. (2000). Visualization of labile zinc and its role in apoptosis of primary airway epithelial cells and cell lines. American Journal of Physiology-Lung Cellular and Molecular Physiology, 279(6 23-6), L1172-L1183. Scopus95 WoS85 Europe PMC66 |
| 2000 | TruongTran, A., Ho, L., Chai, F., & Zalewski, P. (2000). Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death. Journal of Nutrition, 130(5), 1459S-1466S. Scopus192 WoS166 Europe PMC117 |
| 2000 | Ho, L., Ratnaike, R., & Zalewski, P. (2000). Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. Biochemical and Biophysical Research Communications, 268(1), 148-154. Scopus37 WoS35 Europe PMC22 |
| 2000 | Chai, F., TruongTran, A., Evdokiou, A., Young, G., & Zalewski, P. (2000). Intracellular zinc depletion induces caspase activation and p21Waf1/Cip1 cleavage in human epithelial cell lines. Journal of Infectious Diseases, 182(Suppl 1), S85-S92. Scopus50 WoS48 Europe PMC42 |
| 2000 | Chai, F., Evdokiou, A., Young, G., & Zalewski, P. (2000). Involvement of p21Waf1/Cip1 and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. Carcinogenesis, 21(1), 7-14. Scopus82 WoS75 Europe PMC59 |
| 2000 | Chai, F., Young, G. P., & Zalewski, P. D. (2000). Butyrate-resistant colorectal cancer cells are also resistant to sulindac sulfide and sulfone.. GASTROENTEROLOGY, 118(4), A1383. |
| 2000 | Chai, F., Evdokiou, A., Young, G. P., & Zalewski, P. D. (2000). The effect of zinc depletion on apoptosis in colorectal cancer cells.. GASTROENTEROLOGY, 118(4), A530. |
| 1999 | Chai, F. G., Evdokiou, A., Young, G., & Zalewski, P. (1999). Involvement of p21Waf1 and its cleavage by caspase-3 in apoptosis of colon cancer cells by butyrate.. GASTROENTEROLOGY, 116(4), A385. |
| 1999 | Leonardos, L., Butler, L., Hewett, P., Zalewski, P., & Cowled, P. (1999). The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma.. Cancer Letters, 143(1), 29-35. Scopus20 WoS16 Europe PMC15 |
| 1999 | Chai, F., Truong-Tran, A., Ho, L., & Zalewski, P. (1999). Regulation of caspase activation and apoptosis by cellular zinc fluxes and zinc deprivation: a review. Immunology and Cell Biology, 77(3), 272-278. Scopus157 WoS146 Europe PMC112 |
| 1997 | Medina, V., Edmonds, B., Young, G., James, R., Appleton, S., & Zalewski, P. (1997). Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin a (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.. Cancer Research, 57(17), 3697-3707. Scopus383 WoS380 Europe PMC265 |
| 1997 | Rodopoulos, T., Pittet, P. A., Mahadevan, I., Lincoln, S., Ward, A., Duckworth, P., . . . Zalewski, P. (1997). Complexation of zinc(II) and other divalent metal ions by the fluorophore 2-methyl-8-(toluene-p-sulfonamido)-6-quinolyloxyacetic acid in 50% aqueous ethanol. Journal of the Chemical Society, Dalton Transactions, 20(20), 3879-3882. Scopus45 WoS43 |
| 1997 | Zalewski, P. D., Medina, V., James, R., & Young, G. P. (1997). Novel pathway of apoptosis of colorectal cancer cells, independent of activation of protease CPP-32. GASTROENTEROLOGY, 112(4), A689. WoS1 |
| 1997 | Zalewski, P. D., Medina, V., James, R., Appleton, S., & Young, G. P. (1997). Butyrate induces apoptosis of colorectal cancer cells by a process initiated by inhibition of histone deacetylase.. GASTROENTEROLOGY, 112(4), A689. WoS1 |
| 1996 | Mahadevan, I., Kimber, M., Lincoln, S., Tiekink, E., Ward, A., Betts, W., . . . Zalewski, P. (1996). The synthesis of zinquin ester and zinquin acid, zinc (II)-specific fluorescing agents for use in the study of biological zinc(ii).. Australian Journal of Chemistry, 49(5), 561-568. Scopus59 WoS56 |
| 1996 | Zalewski, P., Jian, X., Soon, L., Breed, W., Seamark, R., Lincoln, S., . . . Sun, F. Z. (1996). Changes in distribution of labile zinc in mouse spermatozoa during maturation in the epididymis assessed by the fluorophore Zinquin. Reproduction, Fertility and Development, 8(7), 1097-1105. Scopus61 WoS58 Europe PMC40 |
| 1996 | Zalewski, P. (1996). Programmed cell death. Today's Life Science, 8, 13-14. |
| 1996 | Zalewski, P. (1996). Zinc and immunity: Implications for growth, survival and function of lymphoid cells. Journal of Nutritional Immunology, 4(3), 39-101. Scopus28 |
| 1994 | Zalewski, P. D., Forbes, I. J., Seamark, R. F., Borlinghaus, R., Betts, W. H., Lincoln, S. F., & Ward, A. D. (1994). Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin. Chemistry and Biology, 1(3), 153-161. Scopus180 Europe PMC104 |
| 1994 | Coyle, P., Zaleewski, P. D., Philcox, J. C., Forbes, I. J., Ward, A. D., Lincoln, S. F., . . . Rofe, A. M. (1994). Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: Relationship to metallothionein and intracellular zinc. Biochemical Journal, 303(3), 781-786. Scopus140 WoS138 Europe PMC99 |
| 1994 | Zalewski, P. D., Millard, S. H., Forbes, I. J., Kapaniris, O., Slavotinek, A., Betts, W. H., . . . Mahadevan, I. (1994). Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc. Journal of Histochemistry and Cytochemistry, 42(7), 877-884. Scopus248 WoS239 Europe PMC180 |
| 1993 | Zalewski, P. D., Forbes, I. J., & Betts, W. H. (1993). Correlation of apoptosis with change in intracellular labile Zn(II) using Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). Biochemical Journal, 296(2), 403-408. Scopus473 WoS470 Europe PMC324 |
| 1992 | Forbes, I. J., Zalewski, P. D., Giannakis, C., & Cowled, P. A. (1992). Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester. Experimental Cell Research, 198(2), 367-372. Scopus120 WoS129 Europe PMC84 |
| 1991 | Giannakis, C., Forbes, I. J., & Zalewski, P. D. (1991). Ca2+ Mg2+-dependent nuclease: Tissue distribution, relationship to inter-nucleosomal DNA fragmentation and inhibition by Zn2+. Biochemical and Biophysical Research Communications, 181(2), 915-920. Scopus135 WoS143 Europe PMC88 |
| 1991 | Zalewski, P. D., Forbes, I. J., & Giannakis, C. (1991). Physiological role for zinc in prevention of apoptosis (gene-directed death). Biochemistry International, 24(6), 1093-1101. Scopus118 WoS123 Europe PMC71 |
| 1991 | Zalewski, P. D., Forbes, L. J., Giannikis, C., & Betts, W. H. (1991). Regulation of protein kinase C by Zn2+-dependent interaction with actin. Biochemistry International, 24(6), 1103-1110. Scopus22 WoS25 Europe PMC13 |
| 1991 | Forbes, I. J., Zalewski, P. D., & Giannakis, C. (1991). Role for zinc in a cellular response mediated by protein kinase C in human B lymphocytes. Experimental Cell Research, 195(1), 224-229. Scopus25 WoS30 Europe PMC20 |
| 1990 | Forbes, I. J., Zalewski, P. D., Giannakis, C., & Betts, W. H. (1990). Zinc induces specific association of PKC with membrane cytoskeleton. Biochemistry International, 22(4), 741-748. Scopus22 WoS24 Europe PMC15 |
| 1990 | Zalewski, P. D., Forbes, I. J., Giannakis, C., Cowled, P. A., & Betts, W. H. (1990). Synergy between zinc and phorbol ester in translocation of protein kinase C to cytoskeleton. FEBS Letters, 273(1-2), 131-134. Scopus86 WoS86 Europe PMC55 |
| 1990 | Forbes, I. J., Zalewski, P. D., Giannakis, C., Petkoff, H. S., & Cowled, P. A. (1990). Interaction between protein kinase C and regulatory ligand is enhanced by a chelatable pool of cellular zinc. Bba Molecular Cell Research, 1053(2-3), 113-117. Scopus57 WoS62 Europe PMC42 |
| 1989 | Hurst, N. P., Gorjatschko, L., Betts, W. H., Zalewski, P. D., & Forbes, I. J. (1989). Auranofin modulates human neutrophil superoxide production and protein phosphorylation. Rheumatology International, 8(6), 245-250. Scopus10 WoS11 Europe PMC7 |
| 1989 | Forbes, I. J., Zalewski, P. D., Hurst, N. P., Giannakis, C., & Whitehouse, M. W. (1989). Zinc increases phorbol ester receptors in intact B-cells, neutrophil polymorphs and platelets. FEBS Letters, 247(2), 445-447. Scopus21 WoS30 Europe PMC21 |
| 1988 | Zalewski, P. D., Forbes, I. J., Valente, L., Apostolou, S., & Hurst, N. P. (1988). Translocation of protein kinase C to a Triton-insoluble sub-cellular compartment induced by the lipophilic gold compound auranofin. Biochemical Pharmacology, 37(7), 1415-1417. Scopus23 WoS23 Europe PMC18 |
| 1987 | FRENCH, J. K., HURST, N. P., ZALEWSKI, P. D., VALENTE, L., & FORBES, I. J. (1987). CALCIUM IONOPHORE A23187 ENHANCES HUMAN NEUTROPHIL SUPEROXIDE RELEASE, STIMULATED BY PHORBOL DIBUTYRATE, BY CONVERTING PHORBOL ESTER RECEPTORS FROM A LOW-AFFINITY TO HIGH-AFFINITY STATE. FEBS LETTERS, 212(2), 242-246. WoS25 Europe PMC17 |
| 1987 | FRENCH, J. K., HURST, N. P., ZALEWSKI, P. D., VALENTE, L., & FORBES, I. J. (1987). THE ROLE OF CALCIUM AND PROTEIN-KINASE-C IN NEUTROPHIL SUPEROXIDE RELEASE. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 17(1), 117. |
| 1987 | Zalewski, P. D., Forbes, I. J., Valente, L., & Hurst, N. P. (1987). Auranofin increases the affinity of phorbol dibutyrate receptors in chronic lymphocytic leukemia cells (B cells). Journal of Immunology, 138(9), 3005-3009. Scopus10 WoS9 Europe PMC7 |
| 1986 | ZALEWSKI, P. D., FORBES, I. J., & VALENTE, L. (1986). CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS ARE BLOCKED EARLY IN B-CELL ACTIVATION. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 16(1), 158. |
| 1986 | ZALEWSKI, P. D., FORBES, I. J., VALENTE, L., & HURST, N. (1986). EARLY EVENT IN B-CELL ACTIVATION IS PHOSPHORYLATION OF A RECEPTOR FOR MOUSE ERYTHYROCYTES. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 16(1), 174. |
| 1986 | Hurst, N. P., Zalewski, P. D., Forbes, I. J., & Valente, L. (1986). Calcium ionophore A23187 primes human B-cells for activation by phorbol dibutyrate by converting receptors for phorbol dibutyrate from a low to high affinity state. Biochemical and Biophysical Research Communications, 138(2), 554-559. Scopus12 WoS16 Europe PMC12 |
| 1984 | Zalewski, P. D., Forbes, I. J., Valente, L., & Comacchio, R. (1984). Mechanism of induction of mouse erythrocyte receptor switch in human B cells. Journal of Immunology, 133(3), 1278-1282. Scopus6 WoS7 Europe PMC6 |
| 1984 | Forbes, I. J., Zalewski, P. D., Valente, L., & Comacchio, R. (1984). A subclass of albumin recognized by inhibition of phosphatidylethanolamine-mediated agglutination of mouse erythrocytes. Bba Biomembranes, 771(1), 16-22. Scopus2 WoS3 |
| 1984 | Zalewski, P. D., Valente, L., & Forbes, I. J. (1984). A phosphatidylethanolamine-containing complex on human B cells that mediates rosette formation with mouse erythrocytes. Journal of Immunology, 132(5), 2491-2495. Scopus1 WoS6 |
| 1983 | Forbes, I. J., Zalewski, P. D., & Valente, L. (1983). Agglutination of mouse erythrocytes by binding of non-choline phospholipids to A 70 000-Dalton protein. Bba Biomembranes, 732(1), 179-185. Scopus2 WoS3 Europe PMC1 |
| 1982 | Zalewski, P. D., Forbes, I. J., Gee, D., & Valente, L. (1982). Two maturation-associated mouse erythrocyte receptors of human B cells. II. Isolation and partial characterization of a B-cell lectin with specificity of R1. Clinical and Experimental Immunology, 47(2), 405-413. Scopus3 Europe PMC2 |
| 1982 | Forbes, I. J., Zalewski, P. D., & Valente, L. (1982). Human B-lymphocyte maturation sequence revealed by TPA-induced differentiation of leukaemic cells. Immunobiology, 163(1), 1-6. Scopus1 WoS5 Europe PMC1 |
| 1982 | Roelcke, D., Forbes, I. J., Zalewski, P. D., Dörken, B., & Lenhard, V. (1982). A further subspecificity within human monoclonal anti-Pr cold agglutinins. Blut, 45(2), 109-114. Scopus4 WoS5 Europe PMC2 |
| 1982 | Forbes, I. J., Zalewski, P. D., Valente, L., & Gee, D. (1982). Two maturation-associated mouse erythrocyte receptors of human B cells. I. Identification of four human B-cell subsets. Clinical and Experimental Immunology, 47(2), 396-404. Scopus10 Europe PMC12 |
| 1982 | ZALEWSKI, P. D., FORBES, I. J., GEE, D., & VALENTE, L. (1982). 2 MATURATION-ASSOCIATED MOUSE ERYTHROCYTE RECEPTORS OF HUMAN B-CELLS .2. ISOLATION AND PARTIAL CHARACTERIZATION OF A B-CELL LECTIN WITH SPECIFICITY OF R1. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 47(2), 405-413. WoS5 |
| 1982 | FORBES, I. J., ZALEWSKI, P. D., VALENTE, L., & GEE, D. (1982). 2 MATURATION-ASSOCIATED MOUSE ERYTHROCYTE RECEPTORS OF HUMAN B-CELLS .1. IDENTIFICATION OF 4 HUMAN B-CELL SUBSETS. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 47(2), 396-404. WoS20 |
| 1981 | ZALEWSKI, P. D., FORBES, I. J., UHLENBRUCK, G., & VALENTE, L. (1981). LYMPHOCYTE-B SPECIFICITY OF LECTINS OF CEPAEA-NEMORALIS AND DOLICHOS-BIFLORUS - PARADOXICAL BINDING OF ANTI-A ACTIVE LECTINS TO HUMAN-LYMPHOCYTE SUBCLASSES. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 44(2), 304-314. WoS3 |
| 1981 | Forbes, I. J., Zalewski, P. D., Valente, L., & Murray, A. W. (1981). Loss of receptor activity for mouse erythrocytes precedes tumour promoter-induced maturation of chronic lymphocytic leukaemia cells. Cancer Letters, 14(2), 187-192. Scopus11 WoS23 Europe PMC14 |
| 1981 | Zalewski, P. D., Forbes, I. J., Uhlenbruck, G., & Valente, L. (1981). B lymphocyte specificity of lectins of Cepaea nemoralis and Dolichos biflorus: Paradoxical binding of anti-A active lectins to human lymphocyte subclasses. Clinical and Experimental Immunology, 44(2), 304-314. Scopus1 Europe PMC2 |
| 1979 | Forbes, I. J., Zalewski, P. D., Cowled, P. A., & Sage, R. E. (1979). Maturation in B lymphocytic leukaemia. Journal of Clinical and Laboratory Immunology, 1(4), 329-331. Scopus1 Europe PMC1 |
| 1979 | Forbes, I. J., Zalewski, P. D., Cowled, P., Lander, H., Sage, R. E., & Dale, B. (1979). Null cell chronic lymphocytic leukaemia. Medical Journal of Australia, 1(3), 72-74. Scopus1 WoS4 Europe PMC1 |
| 1979 | Leong, A. S. Y., Forbes, I. J., Cowled, P. A., Sage, R. E., Black, R. B., Dale, B., & Zalewski, P. D. (1979). Surface marker studies in chronic lymphocytic leukaemia and non-hodgkin's lymphoma. Pathology, 11(3), 461-471. Scopus8 WoS14 Europe PMC8 |
| 1979 | Zalewski, P. D., & Forbes, I. J. (1979). Studies of the human lymphocyte-mouse erythrocyte bond. Clinical and Experimental Immunology, 36(3), 536-546. Scopus9 WoS22 Europe PMC12 |
| 1979 | Forbes, I. J., Zalewski, P. D., & Doerken, B. (1979). A simple immunolatex procedure for light and fluorescence microscopy. Immunobiology, 156(1-2), 138-141. Scopus2 WoS3 Europe PMC4 |
| 1979 | LEONG, A. S. Y., COWLED, P., BLACK, R. B., SAGE, R. E., ZALEWSKI, P., & FORBES, I. J. (1979). APPLICATION OF IMMUNOLOGICAL SURFACE MARKER TECHNIQUES TO THE CHARACTERIZATION OF LYMPHOPROLIFERATIVE DISORDERS. PATHOLOGY, 11(2), 313. |
| 1978 | LEONG, A. S. Y., COWLED, P. A., ZALEWSKI, P. D., BURRY, J. N., MEREDITH, D. J., & FORBES, I. J. (1978). Erythroderma, an unusual manifestation of B cell lymphoma. British Journal of Dermatology, 99(1), 99-106. Scopus14 WoS13 Europe PMC12 |
| 1978 | Forbes, I. J., Zalewski, P. D., Leongi, A. S. Y., Sage, R. E., Dale, B., & Cowled, P. A. (1978). B Cell Leukaemia Distinguished from Chronic Lymphocytic Leukaemia by Surface Markers. Australian and New Zealand Journal of Medicine, 8(5), 532-538. Scopus7 WoS12 Europe PMC9 |
| 1976 | Forbes, I. J., & Zalewski, P. D. (1976). A subpopulation of human B lymphocytes that rosette with mouse erythrocytes. Clinical and Experimental Immunology, 26(1), 99-107. Scopus55 WoS113 Europe PMC55 |
| Year | Citation |
|---|---|
| 2018 | Hai, B. T., Jakobczak, R., Beltrame, J., Hodge, S., & Zalewski, P. D. (2018). IMMUNOLOCALIZATION OF ZINC TRANSPORTERS AND METALLOTHIONEINS SUPPORTS A POTENTIAL ROLE OF ZINC IN ENDOTHELIUM-SMOOTH MUSCLE CROSS TALK IN VASCULAR PHYSIOLOGY AND COPD. In RESPIROLOGY Vol. 23 (pp. 63). WILEY. |
| 2015 | Mohanasundaram, D., Zalewski, P., Drogemullar, C., Loudovaris, T., Kay, T., & Coates, T. (2015). Transcriptional and translational regulation of zinc transporter 8 (ZnT8) in human type 1 diabetic (T1D) pancreatic islets. In XENOTRANSPLANTATION Vol. 22 (pp. S137-S138). Melbourne, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | Mohanasundaram, D., Zalewski, P., Drogemullar, C., Loudovaris, T., Kay, T., & Coates, T. (2015). TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF ZINC TRANSPORTER 8 (ZNT8) IN HUMAN TYPE 1 DIABETIC (T1D) PANCREATIC ISLETS.. In TRANSPLANTATION Vol. 99 (pp. S227-S228). Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS. |
| 2013 | Bosco, M., Mohanasundaram, D., Zalewski, P., Drogemuller, C., Coyle, P., Rofe, A., & Coates, P. T. H. (2013). Loss of zinc and alteration of zinc transporters in db/db mice pancreatic islets in early type 2 diabetes. In Abstracts from the 31st Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, as published in Immunology & Cell Biology Vol. 91 (pp. A23). Canberra, ACT: Nature Publishing Group. DOI |
| 2013 | Sharif, R., Thomas, P., Zalewski, P., O'Callaghan, N., & Fenech, M. (2013). ZINC DEFICIENCY INCREASES TELOMERE LENGTH AND IS ASSOCIATED WITH INCREASED TELOMERE BASE DAMAGE, DNA STRAND BREAKS AND CHROMOSOMAL INSTABILITY. In ANNALS OF NUTRITION AND METABOLISM Vol. 63 (pp. 268). KARGER. |
| 2013 | Bosco, M., Mohanasundaram, D., Drogemuller, C., Zalewski, P., & Coates, P. T. (2013). Post Translational Change in The Regulation of Zinc and Zinc Transporters in a Type 2 Diabetic db/db Mice Pancreatic Islets. In TRANSPLANTATION Vol. 96 (pp. S137). Monterey, CA: LIPPINCOTT WILLIAMS & WILKINS. |
| 2011 | Mee, C. A., Lang, C., Zalewski, P., Mohanasundaram, D. M., Milner, C. R., Drogemuller, C. J., & Coates, P. T. H. (2011). ZINC TRANSPORTER ZIP1 SPECIFIC GENE EXPRESSION KNOCK DOWN ALTERS THE EXPRESSION PROFILE OF OTHER CRITICAL ZINC TRANSPORTERS OF THE MOUSE PANCREAS. In IMMUNOLOGY AND CELL BIOLOGY Vol. 89 (pp. A11). ANU Campus, Canberra, AUSTRALIA: NATURE PUBLISHING GROUP. |
| 2011 | Lester, S., Rischmueller, M., Tan, L., Wormald, P., Zalewski, P., Appleton, S., . . . Hill, C. (2011). THE PREVALENCE OF SICCA SYMPTOMS, AND THEIR ASSOCIATION WITH ASTHMA AND SINUSITIS, IN A COMMUNITY SAMPLE. In INTERNAL MEDICINE JOURNAL Vol. 41 (pp. 11). WILEY-BLACKWELL. |
| 2011 | Dencey, B. M., Peter, Z., Daisy, M., & Coates, P. T. H. (2011). DOWN REGULATION OF ZINC TRANSPORTERS ZIP14 AND ZNT8 IN NATIVE PANCREATIC ISLETS OF TYPE 2 DIABETIC DB/DB MICE. In IMMUNOLOGY AND CELL BIOLOGY Vol. 89 (pp. A33). ANU Campus, Canberra, AUSTRALIA: NATURE PUBLISHING GROUP. |
| 2011 | Daisy, M., Chris, D., Mariea, B., Peter, Z., & Toby, C. (2011). ALTERATION OF ZINC AND DIFFERENTIAL EXPRESSION OF ZINC TRANSPORTERS IN DIABETIC PANCREATIC ISLETS. In IMMUNOLOGY AND CELL BIOLOGY Vol. 89 (pp. A33). ANU Campus, Canberra, AUSTRALIA: NATURE PUBLISHING GROUP. |
| 2010 | Zalewski, P., Murgia, C., Roscioli, E., Lang, C., Tran, H., Stoltenberg, M., . . . Ruffin, R. (2010). APICAL LOCALIZATION OF ZINC TRANSPORTER ZNT4 IN HUMAN AIRWAY EPITHELIAL CELLS AND ITS LOSS IN A MURINE MODEL OF ALLERGIC AIRWAY INFLAMMATION. In RESPIROLOGY Vol. 15 (pp. 41). WILEY. |
| 2009 | Sharif, R., Butler, R., Thomas, P., Zalewski, P., Graham, R., & Fenech, M. (2009). THE EFFECTS OF DIFFERENT ZINC SALTS ON CELL PROLIFERATION AND GENOMIC STABILITY IN WIL2NS CELL-LINES. In ANNALS OF NUTRITION AND METABOLISM Vol. 55 (pp. 459). KARGER. |
| 2009 | John, D. C., Daisy, M., Clare, M., Chiara, M., Peter, Z., Clyde, M., . . . Toby, C. (2009). VARIABILITY OF ZINC TRANSPORTER GENE EXPRESSION IN ISOLATED HUMAN ISLETS: IN PARTICULAR ZIP14 AND THE β-CELL SPECIFIC ZNT8. In IMMUNOLOGY AND CELL BIOLOGY Vol. 87 (pp. A15). ANU Campus, Manning Clark Ctr, Canberra, AUSTRALIA: NATURE PUBLISHING GROUP. |
| 2009 | Mohanasundaram, D., Drogemuller, C., Brealey, J., Milton, A., Murgia, C., Lane, C., . . . Coates, T. (2009). Common marmoset monkeys - a new world primate model for diabetic research - a comparision with human pancreatic islets. In XENOTRANSPLANTATION Vol. 16 (pp. 350). Venice, ITALY: WILEY-BLACKWELL PUBLISHING, INC. |
| 2009 | Drogemuller, C. J., Mohanasundaram, D. M., Murgia, C., Mee, C., Milner, C. R., Lang, C. J., . . . Coates, P. T. H. (2009). Transcriptome analysis of isolated human pancreatic islets: expression profiles of zinc transporter genes in particular ZnT8 and ZIP14, critical islet marker genes and glucose metabolic genes. In XENOTRANSPLANTATION Vol. 16 (pp. 316). Venice, ITALY: WILEY-BLACKWELL PUBLISHING, INC. |
| 2006 | Murgia, C., Lang, C., Perozzi, G., Ruffin, R., & Zalewski, P. (2006). Zinc fluxes and zinc transporters in the lung and in a mouse model of asthma.. In Zn signals, 16th-21st September, 2006. Siena, Italy. |
| 2006 | Murgia, C., Devirgiliis, C., Zalewski, P., Lang, C., & Perozzi, G. (2006). Zinc fluxes and zinc transporter genes in chronic disease. In The International Conference on Nutrigenomics & Gut Health, from science to a marketable food product, 30th April-3rd May, 2006. Auckland, New Zealand. |
| Year | Citation |
|---|---|
| 2020 | Tran, H., Abdo, A., Jaghoori, A., Jakobczak, R., Beltrame, J., Hodge, S., & Zalewski, P. (2020). ZINC SIGNALLING MAY BE INVOLVED IN PULMONARY HYPERTENSION VIA CO-REGULATION OF NO-INDUCED VASODILATION AND ENDOTHELIN-1-INDUCED VASOCONSTRICTION. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2019 | Hai, B. T., Abdo, A., Jaghoori, A., Jakobczak, R., Beltrame, J. F., Hodge, S., & Zalewski, P. D. (2019). IS ZINC A NOVEL VASCULAR SIGNALING MESSENGER AND TARGET IN PULMONARY HYPERTENSION?. Poster session presented at the meeting of RESPIROLOGY. WILEY. DOI |
| 2019 | Tran, H., Maiolo, S., Abdo, A., Jacobczak, R., Beltrame, J., Reynolds, P., . . . Hodge, S. (2019). Hypoxia-induced reduction in no signalling as well as increased oxidative stress and inflammation are associated with dysregulated zinc homeostasis in endothelial cells. Poster session presented at the meeting of Respirology. Broadbeach, Qld.: Wiley. |
| 2018 | Hamon, R., Tran, H., Zalewski, P., & Hodge, S. (2018). ALVEOLAR MACROPHAGE ZINC HOMEOSTASIS IS DYSREGULATED BY EXPOSURE TO CIGARETTE SMOKE. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2017 | Roscioli, E., Bac-Tran, H., Jersmann, H., Hodge, G., Hopkins, E., Hamon, R., . . . Hodge, S. (2017). Zinc dyshomeostasis and autophagy as critical determinants for airway epithelial dysfunction in COPD. Poster session presented at the meeting of Proceedings of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ)Annual Scientific Meeting, 2017, as published in Respirology. Canberra, ACT: Wiley. |
| 2016 | Roscioli, E., Bac-Tran, H., Hamon, R., Zalewski, P., Hodge, G., Reynolds, P., & Hodge, S. (2016). AUTOPHAGY-RELATED EPITHELIAL DISINTEGRATION IN AN EX VIVO MODEL OF COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. |
| 2016 | Roscioli, E., Bac-Tran, H., Hamon, R., Zalewski, P., & Hodge, S. J. (2016). Association Of Increased Autophagy In COPD And Dysregulation Of Zinc Handling Systems. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. San Francisco, CA: AMER THORACIC SOC. |
| 2015 | Tran, H., Zalewski, P., Roscioli, E., Barnawi, J., Hodge, G., Reynolds, P., & Hodge, S. (2015). ZINC DYSHOMEOSTASIS IS LINKED TO DEFECTIVE LUNG MACROPHAGE PHAGOCYTIC FUNCTION AND AIRWAY INFLAMMATION IN MICE EXPOSED TO CIGARETTE SMOKE. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | Roscioli, E., Tran, H., Zalewski, P., Hodge, G., Carrol, A., Rix, S., . . . Hodge, S. (2015). ZINC HANDLING SYSTEM AND AUTOPHAGY IN COPD. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | Roscioli, E., Hamon, R., Ruffin, R., Zalewski, P., Hodge, S., Grant, J., & Lester, S. (2015). BIRC2 SINGLE NUCLEOTIDE POLYMORPHISMS MODULATE THE SEVERITY OF ASTHMA IN A CAUCASIAN COMMUNITY-BASED COHORT. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | Lau, A., Bosco, M., Lester, S., Roscioli, E., Zalewski, P., & Rischmueller, M. (2015). ARA3 Inflammasome activation in salivary gland epithelial cells - a disease model for primary sjögren's syndrome. Poster session presented at the meeting of Abstracts of the Australian Rheumatology Associationin conjunction with Rheumatology Health Professionals Association, 56th Annual Scientific Meeting, as published in Internal Medicine Journal. Adelaide, South Australia: Wiley. DOI |
| 2014 | Zalewski, P., Hamon, R., Tran, H., Jersmann, H., Hodge, S., & Bosco, M. (2014). Zinc and zinc transporters in human alveolar and THP-1 macrophages and roles in phagocytosis/efferocytosis. Poster session presented at the meeting of European Respiratory Journal. Munich, Germany: European Respiratory Society. |
| 2014 | Tran, H., Roscioli, E., Tan, N., Cooksley, C., Zalewski, P., Wormald, P., & Vreudge, S. (2014). ABSENT IN MELANOMA 2 (AIM2) INFLAMMASOME ACTIVATION IN SINUS EPITHELIUM OF ASTHMATIC CHRONIC RHINOSINUSITIS PATIENTS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. |
| 2013 | Mohanasundaram, D., Bosco, M., Zalewski, P., Drogemullar, C., Loudovaris, T., Kay, T., & Coates, T. (2013). Differential Regulation of Zinc Transporters and Metal Binding Proteins in Human Type 1 and type 2 Diabetes. Poster session presented at the meeting of TRANSPLANTATION. Monterey, CA: LIPPINCOTT WILLIAMS & WILKINS. |
| 2010 | Hamon, R., Roscioli, E., Lang, C., Murgia, C., Ruffin, R., & Zalewski, P. (2010). Zinc Chelation Induced Depletion Of X-Linked Inhibitor Of Apoptosis Protein (XIAP) In Airway Epithelial Cells. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. |
| 2000 | Ho, L., Ruffin, R., & Zalewski, P. (2000). Visualisation of zinc (Zn) in granules of mast cells and its role in suppression of NF-KB in airway epithelial cells. Poster session presented at the meeting of Abstracts for the Annual Scientific Meeting of the Thoracic Society of Australia & New Zealand. Victoria, Australia: Blackwell Science Asia. |
| 2000 | TruongTran, A., Ruffin, R., & Zalewski, P. (2000). Visualisation and function of labile zinc (Zn) in primary ciliated airway epithelial cells. Poster session presented at the meeting of Abstracts of the 2000 International Conference of the American Thoracic Society. Toronto, Canada: American Thoracic Society. |
| 2000 | Zalewski, P., TruongTran, A., & Ruffin, R. (2000). Labile zinc prevents apoptosis of malignant respiratory epithelial cells by suppressing a post-mitochondrial event during pro-caspase-3 activation. Poster session presented at the meeting of Abstracts of 2000 International Conference of the American Thoracic Society. Toronto, Canada: American Thoracic Society. |
| 2000 | Ho, L., Ruffin, R., & Zalewski, P. (2000). Visualisation of zinc (Zn) in granules of mast cells and its role in suppression of NF-kB in airway epithelial cells. Poster session presented at the meeting of Abstracts of 2000 International Conference of the American Thoracic Society. Toronto, Canada: American Thoracic Society. |
| Date | Project/ No. | Role | Funding Body | Amount |
|---|---|---|---|---|
| 2018-2020 | Role for zinc and ZIP2 in the action of nitric oxide and in vascular protection against cigarette smoke and cardiovascular disease (1138917) | CIA | NHMRC | $685,940.60 |
| 2016-2018 |
Exploiting increased autophagy in bronchial epithelial cells: a new therapeutic approach for chronic obstructive pulmonary disease (COPD). (1099040)
|
CIB | NHMRC | $2,172,483 |
| 2010-2012 | Alveolar macrophage zinc and zinc transporters and their role in phagocytosis. (627223) | CIA | NHMRC | $278,750 |
| 2008-2010 | Airway epithelial IAPs and their interaction with Zn ions. (519206) | CIA | NHMRC | $250,500 |
| 2006 | Novel markers for zinc transport in airway inflammation and transplanted pancreatic islets, and for susceptibility genes in stroke. (361655). | CIA | NHMRC | $41,500 |
| 2004-2006 | Role of zinc in the respiratory epithelium and asthma. (299005) | CIA | NHMRC | $220,500 |
| 1995-1997 | The visualization and measurement of zinc in living cells using fluorescent probes. (951092) | CID | NHMRC | $189,734 |
| 1988-1989 | Auranofin as tool for investigation of B lymphocyte activation. | CIB | NHMRC | $82,904 |
| 1983-1984 | Prematuration modulation in studies of phorbol ester action and maturation arrest. | CIB | NHMRC | $89,991 |
Honours Program Coordinator (Medicine) at The Adelaide Medical School
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2011 - 2015 | Co-Supervisor | Investigations into the Role of Zinc and Zinc Transporters in the Pathogenesis of Type 2 Diabetes in db/db Mice | Doctor of Philosophy | Doctorate | Full Time | Miss Mariea Dencey Bosco |
| 2008 - 2012 | Co-Supervisor | Zinc and Genomic Stability | Doctor of Philosophy | Doctorate | Full Time | Miss Razinah Sharif |
| 2007 - 2014 | Principal Supervisor | Inhibitor of Apoptosis Proteins as Regulatory Factors in the Normal and Inflamed Airway | Doctor of Philosophy | Doctorate | Full Time | Dr Eugene Roscioli |
| 2003 - 2010 | Co-Supervisor | Airway Inflammation, Diagnosis, Perception of Asthma and Sputum Zinc Levels in a Community Cohort | Doctor of Philosophy | Doctorate | Full Time | Ms Lata Jayaram |
| 1999 - 2002 | Principal Supervisor | INVESTIGATIONS INTO THE ROLE OF ZINC IN NORMAL AND ALLERGIC RESPIRATORY EPITHELIAL CELLS AND TISSUES | Doctor of Philosophy | Doctorate | Full Time | Ms Ai Quynh Truong-Tran |
| 1999 - 2003 | Principal Supervisor | LABILE ZINC AND ITS ROLE IN REGULATION OF PRO-CASPASE-3 AND NF-kB ACTIVATION IN MAST CELLS | Doctor of Philosophy | Doctorate | Full Time | Miss Lien Ho |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2000 - ongoing | Member | International Society for Zinc Biology | - | - |
| 2000 - ongoing | Member | NMRC grant applications program | - | Singapore |
| Date | Title | Engagement Type | Institution | Country |
|---|---|---|---|---|
| 2021 - ongoing | Regional Director Asia/Oceania International Society for Zinc Biology | Scientific Community Engagement | International Society for Zinc Biology | - |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2000 - ongoing | Associate Editor | Genes and Nutrition | - | - |
| Date | Office Name | Institution | Country |
|---|---|---|---|
| 2018 - ongoing | Honours Coordinator for Medicine and Specialities | University of Adelaide | Australia |
