Dr Mohamed Saad
ECR, Tumour Inflammation & Immunotherapy
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Mohamed Saad is a Research Scientist at the South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, Australia. He completed his PhD studies in 2019 at Monash University, Australia. He has authored 37 publications and been awarded numerous highly competitive scholarships, fellowships and awards, including Monash International Postgraduate Research Scholarship, Monash Publication Award, Hudson Postgraduate Travel Fellowship Award, Best Poster Prize at the Lorne Cancer conference, Milstein Travel Award from the International Cytokine and Interferon Society, and Cancer Council Victoria (CCV) Postdoctoral Research Fellowship. In 2024, he was also awarded a Cure Cancer Early Career Research grant and a Tour de Cure grant. He was selected as 1 of 6 Hudson Institute Emerging Leaders in 2021. Dr Saad has presented his work at 18 national and international conferences and symposia, and has been invited to present his work at the University of Kiel, Germany (2019) and Technical University of Munich, Germany (2024). He is an active reviewer for many scientific journals including Oncogene, Molecular Therapy - Nucleic Acids, Molecular Cancer Research, Clinical & Translational Immunology, Cancers, Cytokine, Biomolecules and Cancer Medicine. In 2023, he was invited to edit a book entitled “Patient-derived Xenografts: A Valuable Platform for Translational Cancer Research and Drug Development” to be published (by mid-2024) in the highly regarded laboratory protocol series Methods in Molecular Biology, published by Springer Nature. He also joined the editorial board of Frontiers in Oncology as a Review Editor in 2022. His research interests include elucidating the roles of the ADAM17 protease, rhomboid pseudoproteases and IL-6 cytokine signaling in dysregulated cell proliferation, inflammation and cell death, with a particular focus on lung cancer.
-
Appointments
Date Position Institution name 2019 - 2023 Postdoctoral Scientist Hudson Institute of Medical Research -
Education
Date Institution name Country Title 2015 - 2019 Monash University Australia PhD 2011 - 2014 Alexandria University Egypt M.Sc 2005 - 2010 Alexandria University Egypt B.Sc -
Research Interests
-
Journals
Year Citation 2024 Alanazi, M., Weng, T., McLeod, L., Gearing, L. J., Smith, J. A., Kumar, B., . . . Jenkins, B. J. (2024). Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes. Cancer Science, 115(6), 1834-1850.
Scopus3 Europe PMC22024 Saad, M. I., & Jenkins, B. J. (2024). The Protease ADAM17 at the Crossroads of Disease: Revisiting its Significance in Inflammation, Cancer, and Beyond. The FEBS journal, 291(1), 10-24.
Scopus12 WoS3 Europe PMC112024 Saad, M. I. (2024). Preface. Methods in Molecular Biology, 2806, v. 2022 Dawson, R. E., Deswaerte, V., West, A. C., Tang, K., West, A. J., Balic, J. J., . . . Jenkins, B. J. (2022). STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut, 71(8), 1515-1531.
Scopus28 WoS16 Europe PMC202022 Alhayyani, S., McLeod, L., West, A. C., Balic, J. J., Hodges, C., Yu, L., . . . Jenkins, B. J. (2022). Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer. Oncogene, 41(6), 809-823.
Scopus6 WoS4 Europe PMC62022 Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., West, A. C., West, A. J., . . . Jenkins, B. J. (2022). Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proceedings of the National Academy of Sciences, 119(36), 1-12.
Scopus10 WoS5 Europe PMC72022 Saad, M. I., Weng, T., Lundy, J., Gearing, L. J., West, A. C., Harpur, C. M., . . . Jenkins, B. J. (2022). Blockade of the protease ADAM17 ameliorates experimental pancreatitis. Proceedings of the National Academy of Sciences of USA, 119(42), e2213744119-1-e2213744119-12.
Scopus14 WoS6 Europe PMC92021 Dawson, R. E., Jenkins, B. J., & Saad, M. I. (2021). IL-6 family cytokines in respiratory health and disease. Cytokine, 143, 1-10.
Scopus22 WoS11 Europe PMC132021 Vannitamby, A., Saad, M. I., Aloe, C., Wang, H., Kumar, B., Vlahos, R., . . . Bozinovski, S. (2021). Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model. Cancers, 13(13), 1-16.
Scopus12 WoS9 Europe PMC72021 Saad, M. I., McLeod, L., Hodges, C., Vlahos, R., Rose-John, S., Ruwanpura, S., & Jenkins, B. J. (2021). ADAM17 Deficiency Protects against Pulmonary Emphysema. American Journal of Respiratory Cell and Molecular Biology, 64(2), 183-195.
Scopus17 WoS15 Europe PMC102020 Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., . . . Jenkins, B. J. (2020). Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. American Journal of Pathology, 190(6), 1256-1270.
Scopus18 WoS12 Europe PMC122020 Zhu, D., Kusuma, G. D., Schwab, R., Chan, S. T., Tan, J., Saad, M. I., . . . Lim, R. (2020). Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair. Clinical Science, 134(20), 2665-2679.
Scopus10 WoS6 Europe PMC72020 Saad, M. I., McLeod, L., Yu, L., Ebi, H., Ruwanpura, S., Sagi, I., . . . Jenkins, B. J. (2020). The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis. Carcinogenesis, 41(4), 527-538.
Scopus25 WoS20 Europe PMC162019 Saad., Rose-John., & Jenkins. (2019). ADAM17: An Emerging Therapeutic Target for Lung Cancer. Cancers, 11(9), 1-28.
Scopus60 WoS45 Europe PMC352019 Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., . . . Jenkins, B. J. (2019). Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity. Cancer Research, 79(20), 5272-5287.
Scopus26 WoS20 Europe PMC162019 Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., . . . Jenkins, B. J. (2019). ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.. EMBO molecular medicine, 11(4), 1-19.
Scopus70 WoS53 Europe PMC482018 Tan, J. L., Lau, S. N., Leaw, B., Nguyen, H. P. T., Salamonsen, L. A., Saad, M. I., . . . Lim, R. (2018). Amnion Epithelial Cell-Derived Exosomes Restrict Lung Injury and Enhance Endogenous Lung Repair. Stem Cells Translational Medicine, 7(2), 180-196.
Scopus173 WoS138 Europe PMC1112017 Tawfik, S. H., Haiba, M. M., Saad, M. I., Abdelkhalek, T. M., Hanafi, M. Y., & Kamel, M. A. (2017). Intrauterine diabetic milieu instigates dysregulated adipocytokines production in F1 offspring. JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY, 59(1), 11 pages.
WoS2 Europe PMC22017 Alhomrani, M., Correia, J., Zavou, M., Leaw, B., Kuk, N., Xu, R., . . . Sievert, W. (2017). The human amnion epithelial cell secretome decreases hepatic fibrosis in mice with chronic liver fibrosis. Frontiers in Pharmacology, 8(OCT), 13 pages.
Scopus66 WoS56 Europe PMC442017 Leaw, B., Zhu, D., Tan, J., Muljadi, R., Saad, M. I., Mockler, J. C., . . . Tolcos, M. (2017). Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury. Stem cell research & therapy, 8(1), 46.
Scopus38 WoS32 Europe PMC292017 Moussa, Y. Y., Tawfik, S. H., Haiba, M. M., Saad, M. I., Hanafi, M. Y., Abdelkhalek, T. M., . . . Kamel, M. A. (2017). Disturbed nitric oxide and homocysteine production are involved in the increased risk of cardiovascular diseases in the F1 offspring of maternal obesity and malnutrition. Journal of Endocrinological Investigation, 40(6), 611-620.
Scopus4 WoS3 Europe PMC12016 Hanafi, M. Y., Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., & Kamel, M. A. (2016). In Utero Nutritional Manipulation Provokes Dysregulated Adipocytokines Production in F1 Offspring in Rats. Scientifica, 2016, 9 pages.
Scopus2 WoS1 Europe PMC12016 Saad, M. I., Abdelkhalek, T. M., Haiba, M. M., Saleh, M. M., Hanafi, M. Y., Tawfik, S. H., & Kamel, M. A. (2016). Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring. Journal of Endocrinological Investigation, 39(6), 643-655.
Scopus18 WoS15 Europe PMC122016 Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., Haiba, M. M., Tawfik, S. H., & Kamel, M. A. (2016). Maternal diabetes impairs oxidative and inflammatory response in murine placenta. SpringerPlus, 5(1), 9 pages.
Scopus8 WoS8 Europe PMC42016 Hanafi, M. Y., Abdelkhalek, T. M., Saad, M. I., Saleh, M. M., Haiba, M. M., & Kamel, M. A. (2016). Diabetes-induced perturbations are subject to intergenerational transmission through maternal line. Journal of Physiology and Biochemistry, 72(2), 315-326.
Scopus12 WoS10 Europe PMC82016 Hanafi, M. Y., Saleh, M. M., Saad, M. I., Abdelkhalek, T. M., & Kamel, M. A. (2016). Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Molecular and Cellular Biochemistry, 412(1-2), 269-280.
Scopus39 WoS33 Europe PMC202015 Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., Kamel, M. A., Youssef, M., Tawfik, S. H., & Dominguez, H. (2015). Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells. Endocrine, 50(3), 537-567.
Scopus46 WoS43 Europe PMC252015 Saad, M. I., Kamel, M. A., Abdelkhalek, T. M., Saleh, M. M., & Tawfik, S. H. (2015). Recent patents and advances in regenerative medicine and stem cell therapies for diabetes, cardiovascular and neurodegenerative diseases. Recent Patents on Regenerative Medicine, 5(1), 36-54.
2015 Saad, M. I., Kamel, M. A., & Hanafi, M. Y. (2015). Modulation of adipocytokines production and serum NEFA level by metformin, glimepiride, and sitagliptin in HFD/STZ diabetic rats. Biochemistry Research International, 2015, 7 pages.
Scopus30 WoS19 Europe PMC142015 Tawfik, S. H., Mahmoud, B. F., Saad, M. I., Shehata, M., Kamel, M. A., & Helmy, M. H. (2015). Similar and additive effects of ovariectomy and diabetes on insulin resistance and lipid metabolism. Biochemistry Research International, 2015, 8 pages.
Scopus49 WoS42 Europe PMC242014 I Saad, M., A Kamel, M., Y Hanafi, M., H Helmy, M., & R Shehata, R. (2014). Effect of Sitagliptin and Glimepiride on Glucose Homeostasis and cAMP Levels in Peripheral Tissues of HFD/STZ Diabetic Rats. American Journal of Biomedical Research, 2(3), 52-60.
- Kernen, R. (n.d.). Session 5. Oral Presentation for: The role of salt basins in the race to net zero: a focus on Australian basins and key research topics. Australian Energy Producers Journal, 64(4).
-
Books
-
Book Chapters
-
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Co-Supervisor Optimization of diagnosis and identification of therapeutic targets for advanced lung and pleural malignancy. Master of Philosophy (Medical Science) Master Full Time Miss Jelena Solujic
Connect With Me
External Profiles