Mohamed Saad

Dr Mohamed Saad

ECR, Tumour Inflammation & Immunotherapy

South Australian Immunogenomics Cancer Institute

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Mohamed Saad is a Research Scientist at the South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, Australia. He completed his PhD studies in 2019 at Monash University, Australia, under the supervision of Prof. Brendan Jenkins. He has authored 33 publications and been awarded numerous highly competitive scholarships, fellowships and awards, including Monash International Postgraduate Research Scholarship, Monash Publication Award, Hudson Postgraduate Travel Fellowship Award, Best Poster Prize at the Lorne Cancer conference, Milstein Travel Award from the International Cytokine and Interferon Society, and Cancer Council Victoria (CCV) Postdoctoral Research Fellowship. In 2024, he was also awarded a Cure Cancer Early Career Research grant and a Tour de Cure grant. He was selected as 1 of 6 Hudson Institute Emerging Leaders in 2021. Dr Saad has presented his work at 16 national and international conferences and symposia, and has been invited to present his work at the University of Kiel, Germany (2019) and Technical University of Munich, Germany (2024). He is an active reviewer for many scientific journals including Oncogene, Molecular Therapy - Nucleic Acids, Molecular Cancer Research, Clinical & Translational Immunology, Cancers, Cytokine, Biomolecules and Cancer Medicine. In 2022, he was invited to edit a book entitled “Patient-derived Xenografts: A Valuable Platform for Translational Cancer Research and Drug Development” to be published (by mid-2024) in the highly regarded laboratory protocol series Methods in Molecular Biology, published by Springer Nature. He also joined the editorial board of Frontiers in Oncology as a Review Editor in 2022. His research interests include elucidating the roles of the ADAM17 protease, rhomboid pseudoproteases and IL-6 cytokine signaling in dysregulated cell proliferation, inflammation and cell death, with a particular focus on lung cancer.

  • Journals
    Year Citation
    2024 Alanazi, M., Weng, T., McLeod, L., Gearing, L. J., Smith, J. A., Kumar, B., . . . Jenkins, B. J. (2024). Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes. Cancer Science, 17 pages.
    DOI
    2024 Saad, M. I., & Jenkins, B. J. (2024). The Protease ADAM17 at the Crossroads of Disease: Revisiting its Significance in Inflammation, Cancer, and Beyond. The FEBS journal, 291(1), 10-24.
    DOI Scopus6 WoS3 Europe PMC4
    2023 Saad, M. I., & Jenkins, B. J. (2023). An In Vitro Model for Assessing Acute Lung Injury During Pancreatitis Development Using Primary Mouse Cell Co-cultures. Methods in molecular biology (Clifton, N.J.), 2691, 71-80.
    DOI
    2022 Dawson, R. E., Deswaerte, V., West, A. C., Tang, K., West, A. J., Balic, J. J., . . . Jenkins, B. J. (2022). STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut, 71(8), 1515-1531.
    DOI Scopus21 WoS16 Europe PMC16
    2022 Alhayyani, S., McLeod, L., West, A. C., Balic, J. J., Hodges, C., Yu, L., . . . Jenkins, B. J. (2022). Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer. Oncogene, 41(6), 809-823.
    DOI Scopus4 WoS4 Europe PMC4
    2022 Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., West, A. C., West, A. J., . . . Jenkins, B. J. (2022). Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proceedings of the National Academy of Sciences, 119(36), 1-12.
    DOI Scopus7 WoS5 Europe PMC5
    2022 Saad, M. I., Weng, T., Lundy, J., Gearing, L. J., West, A. C., Harpur, C. M., . . . Jenkins, B. J. (2022). Blockade of the protease ADAM17 ameliorates experimental pancreatitis. Proceedings of the National Academy of Sciences, 119(42), 1-12.
    DOI Scopus10 WoS6 Europe PMC5
    2021 Dawson, R. E., Jenkins, B. J., & Saad, M. I. (2021). IL-6 family cytokines in respiratory health and disease. Cytokine, 143, 1-10.
    DOI Scopus14 WoS11 Europe PMC7
    2021 Vannitamby, A., Saad, M. I., Aloe, C., Wang, H., Kumar, B., Vlahos, R., . . . Bozinovski, S. (2021). Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model. Cancers, 13(13), 1-16.
    DOI Scopus9 WoS9 Europe PMC7
    2021 Saad, M. I., McLeod, L., Hodges, C., Vlahos, R., Rose-John, S., Ruwanpura, S., & Jenkins, B. J. (2021). ADAM17 Deficiency Protects against Pulmonary Emphysema. American Journal of Respiratory Cell and Molecular Biology, 64(2), 183-195.
    DOI Scopus16 WoS15 Europe PMC8
    2020 Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., . . . Jenkins, B. J. (2020). Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. American Journal of Pathology, 190(6), 1256-1270.
    DOI Scopus16 WoS12 Europe PMC11
    2020 Zhu, D., Kusuma, G. D., Schwab, R., Chan, S. T., Tan, J., Saad, M. I., . . . Lim, R. (2020). Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair. Clinical Science, 134(20), 2665-2679.
    DOI Scopus8 WoS6 Europe PMC5
    2020 Saad, M. I., McLeod, L., Yu, L., Ebi, H., Ruwanpura, S., Sagi, I., . . . Jenkins, B. J. (2020). The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis. Carcinogenesis, 41(4), 527-538.
    DOI Scopus22 WoS20 Europe PMC14
    2019 Saad., Rose-John., & Jenkins. (2019). ADAM17: An Emerging Therapeutic Target for Lung Cancer. Cancers, 11(9), 1-28.
    DOI Scopus54 WoS45 Europe PMC33
    2019 Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., . . . Jenkins, B. J. (2019). Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity. Cancer Research, 79(20), 5272-5287.
    DOI Scopus22 WoS20 Europe PMC14
    2019 Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., . . . Jenkins, B. J. (2019). ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.. EMBO molecular medicine, 11(4), 1-19.
    DOI Scopus64 WoS53 Europe PMC43
    2018 Tan, J. L., Lau, S. N., Leaw, B., Nguyen, H. P. T., Salamonsen, L. A., Saad, M. I., . . . Lim, R. (2018). Amnion Epithelial Cell-Derived Exosomes Restrict Lung Injury and Enhance Endogenous Lung Repair. Stem Cells Translational Medicine, 7(2), 180-196.
    DOI Scopus155 WoS138 Europe PMC101
    2017 Tawfik, S. H., Haiba, M. M., Saad, M. I., Abdelkhalek, T. M., Hanafi, M. Y., & Kamel, M. A. (2017). Intrauterine diabetic milieu instigates dysregulated adipocytokines production in F1 offspring. JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY, 59(1), 11 pages.
    DOI WoS2 Europe PMC2
    2017 Alhomrani, M., Correia, J., Zavou, M., Leaw, B., Kuk, N., Xu, R., . . . Sievert, W. (2017). The human amnion epithelial cell secretome decreases hepatic fibrosis in mice with chronic liver fibrosis. Frontiers in Pharmacology, 8(OCT), 13 pages.
    DOI Scopus57 WoS56 Europe PMC41
    2017 Leaw, B., Zhu, D., Tan, J., Muljadi, R., Saad, M. I., Mockler, J. C., . . . Tolcos, M. (2017). Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury. Stem cell research & therapy, 8(1), 46.
    DOI Scopus35 WoS32 Europe PMC26
    2017 Moussa, Y. Y., Tawfik, S. H., Haiba, M. M., Saad, M. I., Hanafi, M. Y., Abdelkhalek, T. M., . . . Kamel, M. A. (2017). Disturbed nitric oxide and homocysteine production are involved in the increased risk of cardiovascular diseases in the F1 offspring of maternal obesity and malnutrition. Journal of Endocrinological Investigation, 40(6), 611-620.
    DOI Scopus4 WoS3 Europe PMC1
    2016 Hanafi, M. Y., Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., & Kamel, M. A. (2016). In Utero Nutritional Manipulation Provokes Dysregulated Adipocytokines Production in F1 Offspring in Rats. Scientifica, 2016, 9 pages.
    DOI Scopus2 WoS1 Europe PMC1
    2016 Saad, M. I., Abdelkhalek, T. M., Haiba, M. M., Saleh, M. M., Hanafi, M. Y., Tawfik, S. H., & Kamel, M. A. (2016). Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring. Journal of Endocrinological Investigation, 39(6), 643-655.
    DOI Scopus18 WoS15 Europe PMC12
    2016 Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., Haiba, M. M., Tawfik, S. H., & Kamel, M. A. (2016). Maternal diabetes impairs oxidative and inflammatory response in murine placenta. SpringerPlus, 5(1), 9 pages.
    DOI Scopus8 WoS8 Europe PMC4
    2016 Hanafi, M. Y., Abdelkhalek, T. M., Saad, M. I., Saleh, M. M., Haiba, M. M., & Kamel, M. A. (2016). Diabetes-induced perturbations are subject to intergenerational transmission through maternal line. Journal of Physiology and Biochemistry, 72(2), 315-326.
    DOI Scopus11 WoS10 Europe PMC8
    2016 Hanafi, M. Y., Saleh, M. M., Saad, M. I., Abdelkhalek, T. M., & Kamel, M. A. (2016). Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Molecular and Cellular Biochemistry, 412(1-2), 269-280.
    DOI Scopus38 WoS33 Europe PMC20
    2015 Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., Kamel, M. A., Youssef, M., Tawfik, S. H., & Dominguez, H. (2015). Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells. Endocrine, 50(3), 537-567.
    DOI Scopus43 WoS43 Europe PMC23
    2015 Saad, M. I., Kamel, M. A., Abdelkhalek, T. M., Saleh, M. M., & Tawfik, S. H. (2015). Recent patents and advances in regenerative medicine and stem cell therapies for diabetes, cardiovascular and neurodegenerative diseases. Recent Patents on Regenerative Medicine, 5(1), 36-54.
    DOI
    2015 Saad, M. I., Kamel, M. A., & Hanafi, M. Y. (2015). Modulation of adipocytokines production and serum NEFA level by metformin, glimepiride, and sitagliptin in HFD/STZ diabetic rats. Biochemistry Research International, 2015, 7 pages.
    DOI Scopus29 WoS19 Europe PMC14
    2015 Tawfik, S. H., Mahmoud, B. F., Saad, M. I., Shehata, M., Kamel, M. A., & Helmy, M. H. (2015). Similar and additive effects of ovariectomy and diabetes on insulin resistance and lipid metabolism. Biochemistry Research International, 2015, 8 pages.
    DOI Scopus42 WoS42 Europe PMC21
    2014 I Saad, M., A Kamel, M., Y Hanafi, M., H Helmy, M., & R Shehata, R. (2014). Effect of Sitagliptin and Glimepiride on Glucose Homeostasis and cAMP Levels in Peripheral Tissues of HFD/STZ Diabetic Rats. American Journal of Biomedical Research, 2(3), 52-60.
    DOI

  • Book Chapters
    Year Citation
    2021 Lundy, J., Saad, M., & Jenkins, B. (2021). A Method for the Establishment of Human Lung Adenocarcinoma Patient-Derived Xenografts in Mice. In P. G. Santiago-Cardona (Ed.), Lung Cancer. Methods and Molecular Biology (Vol. 2279, pp. 165-173). Humana Press.
    DOI Scopus1 Europe PMC1
    2018 Saad, M., & Ruwanpura, S. M. (2018). Tissue processing for stereological analyses of lung structure in chronic obstructive pulmonary disease. In B. J. Jenkins (Ed.), Methods in Molecular Biology (Vol. 1725, pp. 155-162). Springer New York.
    DOI Scopus3 Europe PMC1
    - Youssef, M., Kanagaratham, C., Saad, M. I., & Radzioch, D. (n.d.). Genetics of Allergic Asthma and Current Perspectives on Therapeutic Management. In Asthma - From Childhood Asthma to ACOS Phenotypes. InTech.
    DOI
  • Position: ECR, Tumour Inflammation & Immunotherapy
  • Phone: 83133344
  • Email: mohamed.saad@adelaide.edu.au
  • Campus: West End Health Precinct
  • Building: AHMS - Adelaide Health and Medical Sciences, floor Ninth Floor
  • Org Unit: South Australian Immunogenomics Cancer Institute
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