Mohamed Saad

Research Interests

Cancer Cell Biology Proteins and Peptides Tumour Immunology Oncology and Carcinogenesis Proteomics and Intermolecular Interactions Signal Transduction Cancer Biology and Clinical Oncology Innate Immunity

Dr Mohamed Saad

Grant-Funded Researcher (C)

SAIGENCI

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Mohamed Saad is a Research Scientist at the South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, Australia. He completed his PhD studies in 2019 at Monash University, Australia. He has authored 37 publications and been awarded numerous highly competitive scholarships, fellowships and awards, including Monash International Postgraduate Research Scholarship, Monash Publication Award, Hudson Postgraduate Travel Fellowship Award, Best Poster Prize at the Lorne Cancer conference, Milstein Travel Award from the International Cytokine and Interferon Society, and Cancer Council Victoria (CCV) Postdoctoral Research Fellowship. In 2024, he was also awarded a Cure Cancer Early Career Research grant and a Tour de Cure grant. He was selected as 1 of 6 Hudson Institute Emerging Leaders in 2021. Dr Saad has presented his work at 18 national and international conferences and symposia, and has been invited to present his work at the University of Kiel, Germany (2019) and Technical University of Munich, Germany (2024). He is an active reviewer for many scientific journals including Oncogene, Molecular Therapy - Nucleic Acids, Molecular Cancer Research, Clinical & Translational Immunology, Cancers, Cytokine, Biomolecules and Cancer Medicine. In 2023, he was invited to edit a book entitled “Patient-derived Xenografts: A Valuable Platform for Translational Cancer Research and Drug Development” to be published (by mid-2024) in the highly regarded laboratory protocol series Methods in Molecular Biology, published by Springer Nature. He also joined the editorial board of Frontiers in Oncology as a Review Editor in 2022. His research interests include elucidating the roles of the ADAM17 protease, rhomboid pseudoproteases and IL-6 cytokine signaling in dysregulated cell proliferation, inflammation and cell death, with a particular focus on lung cancer.

Date Position Institution name
2019 - 2023 Postdoctoral Scientist Hudson Institute of Medical Research

Date Institution name Country Title
2015 - 2019 Monash University Australia PhD
2011 - 2014 Alexandria University Egypt M.Sc
2005 - 2010 Alexandria University Egypt B.Sc

Year Citation
2026 Chey, Y. C. J., Kashgari, B., McLeod, L., Radford, G. A., Gearing, L. J., Dawson, R. E., . . . Jenkins, B. J. (2026). Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer. Nature Communications, 17(1), 2477-1-2477-21.
DOI Scopus1 WoS1
2026 Khattab, H., Solujic, J., & Saad, M. I. (2026). ADAM proteases in cytokine biology: Modulators of immune signaling, inflammation and cancer. Biochimica et Biophysica Acta - Molecular Cell Research, 1873(4), 120137-1-120137-22.
DOI Scopus1 WoS2
2026 Chan, S., Hon, K., Dawson, R. E., Weng, T., Solujic, J., Chey, Y. C. J., . . . Saad, M. I. (2026). The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis. British Journal of Pharmacology, 183(15), 4126-4144.
DOI WoS1
2024 Saad, M. I., & Jenkins, B. J. (2024). The Protease ADAM17 at the Crossroads of Disease: Revisiting its Significance in Inflammation, Cancer, and Beyond. The FEBS journal, 291(1), 10-24.
DOI Scopus45 WoS49 Europe PMC44
2024 Alanazi, M., Weng, T., McLeod, L., Gearing, L. J., Smith, J. A., Kumar, B., . . . Jenkins, B. J. (2024). Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes. Cancer Science, 115(6), 1834-1850.
DOI Scopus10 WoS11 Europe PMC10
2024 Saad, M. I. (2024). Preface. Methods in Molecular Biology, 2806, v.
2022 Dawson, R. E., Deswaerte, V., West, A. C., Tang, K., West, A. J., Balic, J. J., . . . Jenkins, B. J. (2022). STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut, 71(8), 1515-1531.
DOI Scopus37 WoS36 Europe PMC32
2022 Alhayyani, S., McLeod, L., West, A. C., Balic, J. J., Hodges, C., Yu, L., . . . Jenkins, B. J. (2022). Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer. Oncogene, 41(6), 809-823.
DOI Scopus11 WoS12 Europe PMC11
2022 Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., West, A. C., West, A. J., . . . Jenkins, B. J. (2022). Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proceedings of the National Academy of Sciences, 119(36), 1-12.
DOI Scopus27 WoS22 Europe PMC23
2022 Saad, M. I., Weng, T., Lundy, J., Gearing, L. J., West, A. C., Harpur, C. M., . . . Jenkins, B. J. (2022). Blockade of the protease ADAM17 ameliorates experimental pancreatitis. Proceedings of the National Academy of Sciences of USA, 119(42), e2213744119-1-e2213744119-12.
DOI Scopus30 WoS26 Europe PMC25
2021 Saad, M. I., McLeod, L., Hodges, C., Vlahos, R., Rose-John, S., Ruwanpura, S., & Jenkins, B. J. (2021). ADAM17 Deficiency Protects against Pulmonary Emphysema. American Journal of Respiratory Cell and Molecular Biology, 64(2), 183-195.
DOI Scopus27 WoS26 Europe PMC24
2021 Dawson, R. E., Jenkins, B. J., & Saad, M. I. (2021). IL-6 family cytokines in respiratory health and disease. Cytokine, 143, 1-10.
DOI Scopus56 WoS51 Europe PMC43
2021 Vannitamby, A., Saad, M. I., Aloe, C., Wang, H., Kumar, B., Vlahos, R., . . . Bozinovski, S. (2021). Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model. Cancers, 13(13), 1-16.
DOI Scopus19 WoS19 Europe PMC15
2020 Saad, M. I., McLeod, L., Yu, L., Ebi, H., Ruwanpura, S., Sagi, I., . . . Jenkins, B. J. (2020). The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis. Carcinogenesis, 41(4), 527-538.
DOI Scopus29 WoS29 Europe PMC28
2020 Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., . . . Jenkins, B. J. (2020). Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. The American Journal of Pathology, 190(6), 1256-1270.
DOI Scopus27 WoS22 Europe PMC21
2020 Zhu, D., Kusuma, G. D., Schwab, R., Chan, S. T., Tan, J., Saad, M. I., . . . Lim, R. (2020). Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair. Clinical Science, 134(20), 2665-2679.
DOI Scopus11 WoS9 Europe PMC8
2019 Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., . . . Jenkins, B. J. (2019). ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.. EMBO molecular medicine, 11(4), 1-19.
DOI Scopus83 WoS77 Europe PMC78
2019 Saad., Rose-John., & Jenkins. (2019). ADAM17: An Emerging Therapeutic Target for Lung Cancer. Cancers, 11(9), 1-28.
DOI Scopus77 WoS66 Europe PMC60
2019 Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., . . . Jenkins, B. J. (2019). Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity. Cancer Research, 79(20), 5272-5287.
DOI Scopus31 WoS31 Europe PMC30
2018 Tan, J. L., Lau, S. N., Leaw, B., Nguyen, H. P. T., Salamonsen, L. A., Saad, M. I., . . . Lim, R. (2018). Amnion Epithelial Cell-Derived Exosomes Restrict Lung Injury and Enhance Endogenous Lung Repair. Stem Cells Translational Medicine, 7(2), 180-196.
DOI Scopus193 WoS175 Europe PMC153
2017 Alhomrani, M., Correia, J., Zavou, M., Leaw, B., Kuk, N., Xu, R., . . . Sievert, W. (2017). The human amnion epithelial cell secretome decreases hepatic fibrosis in mice with chronic liver fibrosis. Frontiers in Pharmacology, 8(OCT), 13 pages.
DOI Scopus80 WoS77 Europe PMC70
2017 Leaw, B., Zhu, D., Tan, J., Muljadi, R., Saad, M. I., Mockler, J. C., . . . Tolcos, M. (2017). Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury. Stem Cell Research Therapy, 8(1), 46.
DOI Scopus41 WoS36 Europe PMC33
2017 Moussa, Y. Y., Tawfik, S. H., Haiba, M. M., Saad, M. I., Hanafi, M. Y., Abdelkhalek, T. M., . . . Kamel, M. A. (2017). Disturbed nitric oxide and homocysteine production are involved in the increased risk of cardiovascular diseases in the F1 offspring of maternal obesity and malnutrition. Journal of Endocrinological Investigation, 40(6), 611-620.
DOI Scopus4 WoS3 Europe PMC1
2017 Tawfik, S. H., Haiba, M. M., Saad, M. I., Abdelkhalek, T. M., Hanafi, M. Y., & Kamel, M. A. (2017). Intrauterine diabetic milieu instigates dysregulated adipocytokines production in F1 offspring. JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY, 59(1), 11 pages.
DOI WoS2 Europe PMC1
2016 Hanafi, M. Y., Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., & Kamel, M. A. (2016). In Utero Nutritional Manipulation Provokes Dysregulated Adipocytokines Production in F1 Offspring in Rats. Scientifica, 2016, 9 pages.
DOI Scopus3 WoS3 Europe PMC2
2016 Saad, M. I., Abdelkhalek, T. M., Haiba, M. M., Saleh, M. M., Hanafi, M. Y., Tawfik, S. H., & Kamel, M. A. (2016). Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring. Journal of Endocrinological Investigation, 39(6), 643-655.
DOI Scopus18 WoS15 Europe PMC13
2016 Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., Haiba, M. M., Tawfik, S. H., & Kamel, M. A. (2016). Maternal diabetes impairs oxidative and inflammatory response in murine placenta. Springerplus, 5(1), 9 pages.
DOI Scopus11 WoS12 Europe PMC8
2016 Hanafi, M. Y., Abdelkhalek, T. M., Saad, M. I., Saleh, M. M., Haiba, M. M., & Kamel, M. A. (2016). Diabetes-induced perturbations are subject to intergenerational transmission through maternal line. Journal of Physiology and Biochemistry, 72(2), 315-326.
DOI Scopus13 WoS12 Europe PMC8
2016 Hanafi, M. Y., Saleh, M. M., Saad, M. I., Abdelkhalek, T. M., & Kamel, M. A. (2016). Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Molecular and Cellular Biochemistry, 412(1-2), 269-280.
DOI Scopus44 WoS39 Europe PMC31
2015 Saad, M. I., Abdelkhalek, T. M., Saleh, M. M., Kamel, M. A., Youssef, M., Tawfik, S. H., & Dominguez, H. (2015). Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells. Endocrine, 50(3), 537-567.
DOI Scopus53 WoS50 Europe PMC39
2015 Saad, M. I., Kamel, M. A., Abdelkhalek, T. M., Saleh, M. M., & Tawfik, S. H. (2015). Recent patents and advances in regenerative medicine and stem cell therapies for diabetes, cardiovascular and neurodegenerative diseases. Recent Patents on Regenerative Medicine, 5(1), 36-54.
DOI
2015 Saad, M. I., Kamel, M. A., & Hanafi, M. Y. (2015). Modulation of adipocytokines production and serum NEFA level by metformin, glimepiride, and sitagliptin in HFD/STZ diabetic rats. Biochemistry Research International, 2015, 7 pages.
DOI Scopus34 WoS28 Europe PMC28
2015 Tawfik, S. H., Mahmoud, B. F., Saad, M. I., Shehata, M., Kamel, M. A., & Helmy, M. H. (2015). Similar and additive effects of ovariectomy and diabetes on insulin resistance and lipid metabolism. Biochemistry Research International, 2015, 8 pages.
DOI Scopus51 WoS50 Europe PMC39
2014 I Saad, M., A Kamel, M., Y Hanafi, M., H Helmy, M., & R Shehata, R. (2014). Effect of Sitagliptin and Glimepiride on Glucose Homeostasis and cAMP Levels in Peripheral Tissues of HFD/STZ Diabetic Rats. American Journal of Biomedical Research, 2(3), 52-60.
DOI

Year Citation
2024 Thompson, J., & Saad, M. I. (2024). Patient-Derived Xenografts: Historical Evolution, Immunocompromised Host Models, and Translational Significance. In M. I. Saad (Ed.), Patient-Derived Xenografts : Methods and Protocols (Vol. 2806, pp. 1-8). Springer Nature : Humana Press.
DOI
2024 Aslani, S., & Saad, M. I. (2024). Patient-Derived Xenograft Models in Cancer Research: Methodology, Applications, and Future Prospects. In M. I. Saad (Ed.), Patient-Derived Xenografts : Methods and Protocols (Vol. 2806, pp. 9-18). Springer Nature : Humana Press.
DOI Scopus5 Europe PMC4
2023 Saad, M. I., & Jenkins, B. J. (2023). An In Vitro Model for Assessing Acute Lung Injury During Pancreatitis Development Using Primary Mouse Cell Co-cultures. In B. J. Jenkins (Ed.), Inflammation and Cancer : Methods and Protocols (Vol. 2691, 2nd ed. ed., pp. 71-80). Springer Nature : Humana Press.
DOI Scopus2 Europe PMC2
2021 Lundy, J., Saad, M., & Jenkins, B. (2021). A Method for the Establishment of Human Lung Adenocarcinoma Patient-Derived Xenografts in Mice. In P. G. Santiago-Cardona (Ed.), Lung Cancer. Methods and Molecular Biology (Vol. 2279, pp. 165-173). Humana Press.
DOI Scopus3 WoS1 Europe PMC1
2018 Saad, M., & Ruwanpura, S. M. (2018). Tissue processing for stereological analyses of lung structure in chronic obstructive pulmonary disease. In B. J. Jenkins (Ed.), Methods in Molecular Biology (Vol. 1725, pp. 155-162). Springer New York.
DOI Scopus5 WoS5 Europe PMC3
- Youssef, M., Kanagaratham, C., Saad, M. I., & Radzioch, D. (2016). Genetics of Allergic Asthma and Current Perspectives on Therapeutic Management. In Asthma - From Childhood Asthma to ACOS Phenotypes. InTech.
DOI

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor Investigating the ADAM family of proteases as potential therapeutic targets in small cell lung cancer Master of Philosophy (Medical Science) Master Full Time Mrs Heba Mohamed Abdelazim Khattab
2025 Principal Supervisor Investigating the rhomboid family of pseudoproteases (iRhoms) as potential therapeutic targets in lung cancer Master of Philosophy (Medical Science) Master Full Time Ms Shermin Yu Tung Chan
2025 Principal Supervisor Investigating the rhomboid family of pseudoproteases (iRhoms) as potential therapeutic targets in lung cancer Master of Philosophy (Medical Science) Master Full Time Ms Shermin Yu Tung Chan
2024 Co-Supervisor Optimization of diagnosis and identification of therapeutic targets for advanced lung and pleural malignancy. Master of Philosophy (Medical Science) Master Full Time Miss Jelena Solujic

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