School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Michael Beard is head of the Viral Pathogenesis Research Laboratory (VPRL) at The University of Adelaide. He completed his PhD in molecular virology from the University of Queensland and after working in the USA with Stanley Lemon at UNC Chapel Hill he returned to Adelaide in 2002 and established the VPRL that focuses on the development of model systems to study complex cellular virus interactions with the ultimate aim to develop novel therapeutic strategies and understand how viruses cause disease. He has been continually funded by the NHMRC for 18 years. A main focus of his laboratory is the study of positive strand RNA viruses of the Flaviviridae family such as hepatitis C virus and other closely related viruses such as Dengue, West Nile Virus and more recently Zika virus. In particular his laboratory is interested in the innate immune response to viral infection and the host antiviral response through the expression of interferon stimulated genes (ISGs). Current projects use cutting edge molecular techniques such as, (i) CRISPR-related genome wide screens to identify novel host factors involved in viral life-cycles, (ii) development of human liver organoid cultures as a model of HBV infection and (iii) characterisation of the novel female hormonally regulated, interferon-epsilon in control of sexual transmission of ZIKV infection of the FRT and the development of novel therapeutics to modulate the innate immune environment of the FRT to limit sexually transmitted infections.
Date Position Institution name 2020 - ongoing Head of Department, Molecular and Biomedical Science The University of Adelaide 2016 - ongoing Faculty Member SAHMRI 2012 - ongoing Associate Professor The University of Adelaide 2010 - 2015 NHMRC Senior Reearch Fellow The University of Adelaide 2005 - 2009 NHMRC RD Wright Research Fellow SA Pathology 2002 - 2004 Royal Adelaide Hospital Florey Fellow Institute of Medical and Veterinary Science 2000 - 2002 Assistant Professor (Research) The University of Texas Medical Branch, Galveston 1997 - 1999 Postdoctoral Scientist University of Texas Medical Branch, Galveston 1996 - 1997 Postdoctoral Scientist University of North Carolina, Chapel Hill
Date Institution name Country Title 1996 The University of Queensland Australia PhD 1992 The University of Adelaide Australia BSc (Hons) 1983 - 1986 University of South Australia Australia Associate Diploma in Medical laboratory Science
Year Citation 2018 Colledge, D., Jackson, K., Sozzi, V., Li, X., Beard, M. R., Eyre, N., . . . Locarnini, S. (2018). Inarigivir Is a Novel Selective Inhibitor of the HBV Replicase Complex in Vitro. In HEPATOLOGY Vol. 68 (pp. 229A). San Francisco, CA: WILEY.
2011 McCartney, E. M., Helbig, K. J., & Beard, M. R. (2011). THE ROLE OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) IN THE HCV LIFE CYCLE. In JOURNAL OF HEPATOLOGY Vol. 54 (pp. S307). Berlin, GERMANY: ELSEVIER.
2010 Eyre, N. S., Turville, S., & Beard, M. (2010). LIVE CELL IMAGING OF HEPATITIS C VIRUS NS5A TRAFFIC DURING AN INFECTIOUS LIFE CYCLE. In HEPATOLOGY Vol. 52 (pp. 376A-377A). Boston, MA: WILEY-BLACKWELL. 2009 Berzsenyi, M. D., Woollard, D. J., McLean, C. A., Preiss, S., Perreau, V. M., Beard, M. R., . . . Roberts, S. K. (2009). DIFFERENTIAL INTRA-HEPATIC T-CELL SIGNALLING ASSOCIATED WITH GB VIRUS C IN HCV/HIV CO-INFECTION. In HEPATOLOGY Vol. 50 (pp. 949A). Boston, MA: JOHN WILEY & SONS INC. 2009 Austin, L., Kharbanda, K. K., Beard, M. R., & Osna, N. A. (2009). ETHANOL AFFECTS EXPRESSION OF RECEPTORS FOR HCV ENTRY IN LIVER CELLS. In HEPATOLOGY Vol. 50 (pp. 1155A-1156A). Boston, MA: JOHN WILEY & SONS INC.
2008 Osna, N. A., Donohue, T. M., White, R. L., Beard, M. R., & Kharbanda, K. K. (2008). ETHANOL AND HEPATITIS C VIRAL (HCV) PROTEINS REGULATE INTERFERON (IFN) SIGNALING IN LIVER CELLS VIA IMPAIRED METHYLATION OF STAT1. In HEPATOLOGY Vol. 48 (pp. 327A-328A). San Francisco, CA: JOHN WILEY & SONS INC.
2006 Seth, D., Beard, M. R., Gorrell, M. D., McCaughan, G. W., & Haber, P. S. (2006). Osteopontin: An early marker for alcoholic liver injury?. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 30 (pp. 89A). Sydney, AUSTRALIA: BLACKWELL PUBLISHING.
2004 Helbig, K. J., Semendric, L., & Beard, M. R. (2004). In vitro modulation of the CXCR3 chemokine I-TAC by HCV replication is influenced by a novel I-TAC promoter polymorphic variant.. In HEPATOLOGY Vol. 40 (pp. 438A). Boston, MA: JOHN WILEY & SONS INC. 2004 Beard, M. R., Semendric, L., Helbig, K. J., Otani, K., & Weinman, S. A. (2004). HCV replication is enhanced in the presence of CYP2E1 and alcohol. In HEPATOLOGY Vol. 40 (pp. 198A-199A). Boston, MA: JOHN WILEY & SONS INC. 2002 Shaw, T., Dean, J., Locarnini, S., & Beard, M. R. (2002). DNA microarray analyses show that lamivudine affects gene expression in HEPG2 cells: Implications for chemotherapy of chronic HBV infection. In HEPATOLOGY Vol. 36 (pp. 633A). BOSTON, MASSACHUSETTS: W B SAUNDERS CO. 2002 Otani, K., Beard, M. R., & Weinman, S. A. (2002). Cellular models for the study of alcohol-hepatitis C interactions.. In HEPATOLOGY Vol. 36 (pp. 398A). BOSTON, MASSACHUSETTS: W B SAUNDERS CO. 2002 Lau, D. T. Y., Ma, H. B., Abdo, B. O., Luxon, B. A., Sinha, M., & Beard, M. R. (2002). Differential hepatic gene expression profiles between steatosis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). In GASTROENTEROLOGY Vol. 122 (pp. A672). W B SAUNDERS CO.
Year Citation 2019 Colledge, D., Jackson, K., Sozzi, V., Li, X., Beard, M., Eyre, N., . . . Locarnini, S. (2019). The novel antiviral agent inarigivir inhibits both nucleos (t)ide analogue and capsid assembly inhibitor resistant HBV in vitro. Poster session presented at the meeting of JOURNAL OF HEPATOLOGY. Vienna, AUSTRIA: ELSEVIER.
2019 Lim, C. K., Tran, B. M., Shue, B., Eyre, N., Flanagan, D., Vincan, E., . . . Beard, M. (2019). Human liver organoids culture as a novel in vitro model of HBV infection. Poster session presented at the meeting of JOURNAL OF HEPATOLOGY. Vienna, AUSTRIA: ELSEVIER. 2014 Tse, E. Y., Helbig, K. J., Van der Hoek, K., McCartney, E. M., George, J., & Beard, M. R. (2014). FATTY ACIDS INDUCE A PRO-INFLAMMATORY GENE EXPRESSION PROFILE IN HUH-7 CELLS AND ATTENUATE THE ANTI-HCV ACTION OF INTERFERON. Poster session presented at the meeting of JOURNAL OF HEPATOLOGY. London, ENGLAND: ELSEVIER SCIENCE BV.
2013 Muller, K., Eyre, N., Van der Hoek, K., Li, K., & Beard, M. (2013). The effect of hepatitis C virus-infected Huh-7 cells on 'bystander' cells. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Melbourne, Vic.: Wiley.
2012 Aloia, A. L., Carr, J., Eyre, N. S., Locarnini, S., Lemon, S., & Beard, M. R. (2012). Development of a genotype 6a/1b chimeric replicon for testing of direct acting antivirals against the HCV protease. Poster session presented at the meeting of HEPATOLOGY. Boston, MA: WILEY-BLACKWELL. 2009 Berzsenyi, M. D., Woollard, D. J., McLean, C. A., Preiss, S., Perreau, V. M., Beard, M. R., . . . Roberts, S. K. (2009). Differential intra-hepatic T-cell signalling associated with GB virus C in HCV/HIV co-infection. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY-BLACKWELL PUBLISHING, INC.
2020. Beard M; Lim C; Warner N. Liver organoid culture as a platform for novel HBV antiviral testing. Australian Centre for HIV and Hepatitis Virology Research. $85,000.00
2020-2022 Doonan C; Sumby C; Bell S; Beard M; Falcaro P. Advancing the Chemistry of Metal-organic Frameworks for Biotechnology. ARC DP200102411. $550,000.00
2018-2020. Beard, Helbig, Lemon, Eyre. NHMRC Project Grant APP1145613. The interplay between viperin, peroxisomes and the cellular innate antiviral response. $556,127
2014-2018 Lloyd, Dore, George, Beard. NHMRC Program Grant APP1053206. Title: Hepatitis C infection: epidemiology pathogenesis and treatment. $5,427,855.00
2015-2016 KJ Helbig, MR Beard, P Revill, P Thomas. Targeting HBV cccDNA using the CRISPR/Cas system. $169,000. Australian Centre for HIV and Hepatitis Virology Research
2010-2015 Beard M. NHMRC Senior Research Fellowship $560,000 total
2009-2013 Cooper, Beard, Dore, Emery, French, Kelleher, Kent, Purcell. NHMRC Program Grant #510448. Title: HIV and HCV Vaccines and Immunopathogenesis. $17,800,000 ($395,000/year/investigator)
2012-2014 Michael Beard, Nicholas Eyre and Stuart Turville. (2012-2014) Imaging the hepatitis C virus life cycle in living cells. NHMRC Project Grant APP1027641 Total: $461,325.000
2012 Michael Beard, Jill Carr and Stephen Locarnini. Analysis of Boceprevir drug susceptibility and resistance in HCV genotype 6. Merck Investigator Studies Program $115,000
2011-2012 Beard M and Locarnini S. Phase II. Development of a laboratory based platform to manage patients who develop antiviral drug-resistance to the STAT-C compounds. ACH2 $113,000 tot
2010-2011 Beard M and Locarnini S. Development of a laboratory based platform to manage patients who develop antiviral drug-resistance to the STAT-C compounds. ACH2 $142,000 total
2010-2011 Beard M and Shackel N. Ultra-deep sequencing of hepatitis C and hepatocytes following interferon exposure Roche Pillar Award. $40,000 total
2008-2010 Beard M & Helbig K. NHMRC Project Grant # 508088 Identification of interferon stimulated genes that limit HCV replication and predict therapeutic outcome. $468,750 total
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor CRISPR Screening Systems to Identify Novel Virus-Host Interactions and Innate Immune Pathways Doctor of Philosophy Doctorate Full Time Mr Xavier Bernard Montin 2021 Principal Supervisor The Impact of Hypoxia on Flavivirus Infection and Innate Immune Responses Doctor of Philosophy Doctorate Full Time Miss Brooke Nyree Trowbridge 2020 Principal Supervisor Identification Of Key Residues Of Dengue Virus NS1 That Are Essential For Its Secretion Doctor of Philosophy Doctorate Full Time Mr Eng Kuan Brandon Tan 2019 Principal Supervisor Genome-wide CRISPR Screens to Identify Novel Factors in Antiviral Innate Immunity Doctor of Philosophy Doctorate Full Time Miss Emily Nicole Kirby
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2021 Principal Supervisor Molecular Characterisation of Flavivirus Interactions with the Host Innate Immune Response Doctor of Philosophy Doctorate Full Time Ms Rosa Cedar Coldbeck-Shackley 2017 - 2022 Principal Supervisor Human Liver Organoids Culture as a Personalised Approach in Assessing HBV Infection and Cellular Responses Doctor of Philosophy Doctorate Full Time Dr Chuan Kok Lim 2017 - 2020 Co-Supervisor Sterility and Immunogenicity of Gamma Irradiated Respiratory Viruses Doctor of Philosophy Doctorate Full Time Miss Eve Victoria Singleton 2015 - 2021 Principal Supervisor Identification of Proviral and Host Restriction Factors that Impact the Flaviviridae Lifecycle Doctor of Philosophy Doctorate Full Time Mr Byron Shue 2013 - 2018 Principal Supervisor The Novel Interacting Partners of Viperin and their Role in Establishing a Host Antiviral State Doctor of Philosophy Doctorate Full Time Ms Onruedee Khantisitthiporn 2011 - 2015 Principal Supervisor Defining and Characterising the anti-HCV Actions of the Interferon-Induced Transmembrane Proteins Doctor of Philosophy Doctorate Full Time Miss Sumudu Kumari Narayana 2011 - 2015 Principal Supervisor Dynamic Imaging of Hepatitis C Virus RNA Localisation and Traffic During Viral Replication Doctor of Philosophy Doctorate Full Time Mr Guillaume Fiches 2010 - 2015 Principal Supervisor The Bystander Effect in Hepatitis C Virus Infection: Cellular Interactions Between Infected Cells and Uninfected Cells Doctor of Philosophy Doctorate Full Time Ms Kate Rebecca Muller 2009 - 2015 Principal Supervisor Improving treatment predictors of HCV therapy and the impact of steatosis on the hepatocyte transcriptome and anti-HCV action of interferon Doctor of Philosophy Doctorate Part Time Dr Edmund Yee-Lai Tse 2007 - 2012 Co-Supervisor Molecular Analysis of Acute and Chronic Duck Hepatitis B Virus (DHBV) Infections in Ducks Doctor of Philosophy Doctorate Full Time Miss Huey Low 2007 - 2014 Co-Supervisor DEVELOPMENT AND ASSESSMENT OF NOVEL VACCINATION STRATEGIES FOR HEPATITIS B VIRUS INFECTION Doctor of Philosophy Doctorate Full Time Mr Devin Teoh 2006 - 2011 Principal Supervisor Molecular Interactions Between Alcohol, Hepatitis C Virus and Interferon Doctor of Philosophy Doctorate Full Time Ms Erin McCartney 2005 - 2010 Co-Supervisor Development of Antiviral Therapies for Hepatitis B Virus Infection Doctor of Philosophy Doctorate Full Time Miss Faseeha Noordeen 2004 - 2008 Co-Supervisor Characterisation of the Events Involved in the Resolution of Acute Duck Hepatitis B Virus Infection Doctor of Philosophy Doctorate Full Time Dr Georget Reaiche 2004 - 2010 Principal Supervisor Expression and function of osteopontin variants in HCV-related liver disease and hepato-cellular carcinoma Doctor of Philosophy Doctorate Full Time Dr Renee Phillips
Date Role Committee Institution Country 2015 - ongoing Member Lorne Infection and Immunity Conference - - 2010 - ongoing Member Organising Committee International Symposium on HCV and Related Viruses - -
Date Role Editorial Board Name Institution Country 2017 - ongoing Associate Editor Virology Journal - - 2013 - ongoing Advisory Board Member Journal of Interferon and Cytokine Research - -
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