Prof Michael Beard
Professor
School of Biological Sciences
College of Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Michael Beard is head of the Viral Pathogenesis Research Laboratory (VPRL) at The University of Adelaide. He completed his PhD in molecular virology from the University of Queensland and after working in the USA with Stanley Lemon at UNC Chapel Hill he returned to Adelaide in 2002 and established the VPRL that focuses on the development of model systems to study complex cellular virus interactions with the ultimate aim to develop novel therapeutic strategies and understand how viruses cause disease. He has been continually funded by the NHMRC for 18 years. A main focus of his laboratory is the study of positive strand RNA viruses of the Flaviviridae family such as hepatitis C virus and other closely related viruses such as Dengue, West Nile Virus and more recently Zika virus. In particular his laboratory is interested in the innate immune response to viral infection and the host antiviral response through the expression of interferon stimulated genes (ISGs). Current projects use cutting edge molecular techniques such as, (i) CRISPR-related genome wide screens to identify novel host factors involved in viral life-cycles, (ii) development of human liver organoid cultures as a model of HBV infection and (iii) characterisation of the novel female hormonally regulated, interferon-epsilon in control of sexual transmission of ZIKV infection of the FRT and the development of novel therapeutics to modulate the innate immune environment of the FRT to limit sexually transmitted infections.
| Date | Position | Institution name |
|---|---|---|
| 2020 - ongoing | Head of Department, Molecular and Biomedical Science | The University of Adelaide |
| 2016 - ongoing | Faculty Member | SAHMRI |
| 2012 - ongoing | Associate Professor | The University of Adelaide |
| 2010 - 2015 | NHMRC Senior Reearch Fellow | The University of Adelaide |
| 2005 - 2009 | NHMRC RD Wright Research Fellow | SA Pathology |
| 2002 - 2004 | Royal Adelaide Hospital Florey Fellow | Institute of Medical and Veterinary Science |
| 2000 - 2002 | Assistant Professor (Research) | The University of Texas Medical Branch, Galveston |
| 1997 - 1999 | Postdoctoral Scientist | University of Texas Medical Branch, Galveston |
| 1996 - 1997 | Postdoctoral Scientist | University of North Carolina, Chapel Hill |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1996 | The University of Queensland | Australia | PhD |
| 1992 | The University of Adelaide | Australia | BSc (Hons) |
| 1983 - 1986 | University of South Australia | Australia | Associate Diploma in Medical laboratory Science |
| Year | Citation |
|---|---|
| 2018 | Colledge, D., Jackson, K., Sozzi, V., Li, X., Beard, M. R., Eyre, N., . . . Locarnini, S. (2018). Inarigivir Is a Novel Selective Inhibitor of the HBV Replicase Complex in Vitro. In HEPATOLOGY Vol. 68 (pp. 229A). San Francisco, CA: WILEY. WoS4 |
| 2011 | McCartney, E. M., Helbig, K. J., & Beard, M. R. (2011). THE ROLE OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) IN THE HCV LIFE CYCLE. In JOURNAL OF HEPATOLOGY Vol. 54 (pp. S307). Berlin, GERMANY: ELSEVIER. DOI |
| 2010 | Eyre, N. S., Turville, S., & Beard, M. (2010). LIVE CELL IMAGING OF HEPATITIS C VIRUS NS5A TRAFFIC DURING AN INFECTIOUS LIFE CYCLE. In HEPATOLOGY Vol. 52 (pp. 376A-377A). Boston, MA: WILEY-BLACKWELL. |
| 2009 | Berzsenyi, M. D., Woollard, D. J., McLean, C. A., Preiss, S., Perreau, V. M., Beard, M. R., . . . Roberts, S. K. (2009). DIFFERENTIAL INTRA-HEPATIC T-CELL SIGNALLING ASSOCIATED WITH GB VIRUS C IN HCV/HIV CO-INFECTION. In HEPATOLOGY Vol. 50 (pp. 949A). Boston, MA: JOHN WILEY & SONS INC. |
| 2009 | Austin, L., Kharbanda, K. K., Beard, M. R., & Osna, N. A. (2009). ETHANOL AFFECTS EXPRESSION OF RECEPTORS FOR HCV ENTRY IN LIVER CELLS. In HEPATOLOGY Vol. 50 (pp. 1155A-1156A). Boston, MA: JOHN WILEY & SONS INC. WoS2 |
| 2008 | Osna, N. A., Donohue, T. M., White, R. L., Beard, M. R., & Kharbanda, K. K. (2008). ETHANOL AND HEPATITIS C VIRAL (HCV) PROTEINS REGULATE INTERFERON (IFN) SIGNALING IN LIVER CELLS VIA IMPAIRED METHYLATION OF STAT1. In HEPATOLOGY Vol. 48 (pp. 327A-328A). San Francisco, CA: JOHN WILEY & SONS INC. WoS5 |
| 2006 | Seth, D., Beard, M. R., Gorrell, M. D., McCaughan, G. W., & Haber, P. S. (2006). Osteopontin: An early marker for alcoholic liver injury?. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 30 (pp. 89A). Sydney, AUSTRALIA: BLACKWELL PUBLISHING. WoS2 |
| 2004 | Helbig, K. J., Semendric, L., & Beard, M. R. (2004). <i>In vitro</i> modulation of the CXCR3 chemokine I-TAC by HCV replication is influenced by a novel I-TAC promoter polymorphic variant.. In HEPATOLOGY Vol. 40 (pp. 438A). Boston, MA: JOHN WILEY & SONS INC. |
| 2004 | Beard, M. R., Semendric, L., Helbig, K. J., Otani, K., & Weinman, S. A. (2004). HCV replication is enhanced in the presence of CYP2E1 and alcohol. In HEPATOLOGY Vol. 40 (pp. 198A-199A). Boston, MA: JOHN WILEY & SONS INC. |
| 2002 | Shaw, T., Dean, J., Locarnini, S., & Beard, M. R. (2002). DNA microarray analyses show that lamivudine affects gene expression in HEPG2 cells: Implications for chemotherapy of chronic HBV infection. In HEPATOLOGY Vol. 36 (pp. 633A). BOSTON, MASSACHUSETTS: W B SAUNDERS CO. |
| 2002 | Otani, K., Beard, M. R., & Weinman, S. A. (2002). Cellular models for the study of alcohol-hepatitis C interactions.. In HEPATOLOGY Vol. 36 (pp. 398A). BOSTON, MASSACHUSETTS: W B SAUNDERS CO. |
| 2002 | Lau, D. T. Y., Ma, H. B., Abdo, B. O., Luxon, B. A., Sinha, M., & Beard, M. R. (2002). Differential hepatic gene expression profiles between steatosis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). In GASTROENTEROLOGY Vol. 122 (pp. A672). W B SAUNDERS CO. |
| Year | Citation |
|---|---|
| 2019 | Colledge, D., Jackson, K., Sozzi, V., Li, X., Beard, M., Eyre, N., . . . Locarnini, S. (2019). The novel antiviral agent inarigivir inhibits both nucleos (t)ide analogue and capsid assembly inhibitor resistant HBV in vitro. Poster session presented at the meeting of JOURNAL OF HEPATOLOGY. Vienna, AUSTRIA: ELSEVIER. DOI |
| 2019 | Lim, C. K., Tran, B. M., Shue, B., Eyre, N., Flanagan, D., Vincan, E., . . . Beard, M. (2019). Human liver organoids culture as a novel in vitro model of HBV infection. Poster session presented at the meeting of JOURNAL OF HEPATOLOGY. Vienna, AUSTRIA: ELSEVIER. |
| 2014 | Tse, E. Y., Helbig, K. J., Van der Hoek, K., McCartney, E. M., George, J., & Beard, M. R. (2014). FATTY ACIDS INDUCE A PRO-INFLAMMATORY GENE EXPRESSION PROFILE IN HUH-7 CELLS AND ATTENUATE THE ANTI-HCV ACTION OF INTERFERON. Poster session presented at the meeting of JOURNAL OF HEPATOLOGY. London, ENGLAND: ELSEVIER SCIENCE BV. DOI |
| 2013 | Muller, K. R., Eyre, N. S., Van der Hoek, K. H., Li, K., & Beard, M. R. (2013). The effect of hepatitis C virus-infected Huh-7 cells on 'bystander' cells. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Melbourne, Vic.: Wiley. DOI |
| 2012 | Aloia, A. L., Carr, J., Eyre, N. S., Locarnini, S., Lemon, S., & Beard, M. R. (2012). Development of a genotype 6a/1b chimeric replicon for testing of direct acting antivirals against the HCV protease. Poster session presented at the meeting of HEPATOLOGY. Boston, MA: WILEY-BLACKWELL. |
| 2009 | Berzsenyi, M. D., Woollard, D. J., McLean, C. A., Preiss, S., Perreau, V. M., Beard, M. R., . . . Roberts, S. K. (2009). Differential intra-hepatic T-cell signalling associated with GB virus C in HCV/HIV co-infection. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY-BLACKWELL PUBLISHING, INC. |
| Year | Citation |
|---|---|
| - | Roennfeldt, A., Allen, T., Trowbridge, B., Beard, M., Whitelaw, M., Russell, D., . . . Peet, D. (n.d.). Graph Pad prism files of all data published in Roennfeldt et al. (2023). Data points for each experiment represents the mean of an individual replicate (and thus each experiment was completed in triplicate with the mean +/- standard deviation graphed).. DOI |
| Year | Citation |
|---|---|
| 2024 | Johnson, S. M., Centofanti, S. M., Bracho, G., Beard, M. R., Carr, J. M., & Eyre, N. S. (2024). Coatomer protein complex I is required for efficient secretion of dengue virus non-structural protein 1. DOI |
| 2023 | Kirby, E., Montin, X., Allen, T., Densumite, J., Trowbridge, B., & Beard, M. (2023). The utility of CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function. DOI |
| 2021 | Ryan, F., Hope, C., Masavuli, M., Lynn, M., Mekonnen, Z., Lip Yeow, A. E., . . . Lynn, D. (2021). Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection. DOI Europe PMC1 |
2020. Beard M; Lim C; Warner N. Liver organoid culture as a platform for novel HBV antiviral testing. Australian Centre for HIV and Hepatitis Virology Research. $85,000.00
2020-2022 Doonan C; Sumby C; Bell S; Beard M; Falcaro P. Advancing the Chemistry of Metal-organic Frameworks for Biotechnology. ARC DP200102411. $550,000.00
2018-2020. Beard, Helbig, Lemon, Eyre. NHMRC Project Grant APP1145613. The interplay between viperin, peroxisomes and the cellular innate antiviral response. $556,127
2014-2018 Lloyd, Dore, George, Beard. NHMRC Program Grant APP1053206. Title: Hepatitis C infection: epidemiology pathogenesis and treatment. $5,427,855.00
2015-2016 KJ Helbig, MR Beard, P Revill, P Thomas. Targeting HBV cccDNA using the CRISPR/Cas system. $169,000. Australian Centre for HIV and Hepatitis Virology Research
2010-2015 Beard M. NHMRC Senior Research Fellowship $560,000 total
2009-2013 Cooper, Beard, Dore, Emery, French, Kelleher, Kent, Purcell. NHMRC Program Grant #510448. Title: HIV and HCV Vaccines and Immunopathogenesis. $17,800,000 ($395,000/year/investigator)
2012-2014 Michael Beard, Nicholas Eyre and Stuart Turville. (2012-2014) Imaging the hepatitis C virus life cycle in living cells. NHMRC Project Grant APP1027641 Total: $461,325.000
2012 Michael Beard, Jill Carr and Stephen Locarnini. Analysis of Boceprevir drug susceptibility and resistance in HCV genotype 6. Merck Investigator Studies Program $115,000
2011-2012 Beard M and Locarnini S. Phase II. Development of a laboratory based platform to manage patients who develop antiviral drug-resistance to the STAT-C compounds. ACH2 $113,000 tot
2010-2011 Beard M and Locarnini S. Development of a laboratory based platform to manage patients who develop antiviral drug-resistance to the STAT-C compounds. ACH2 $142,000 total
2010-2011 Beard M and Shackel N. Ultra-deep sequencing of hepatitis C and hepatocytes following interferon exposure Roche Pillar Award. $40,000 total
2008-2010 Beard M & Helbig K. NHMRC Project Grant # 508088 Identification of interferon stimulated genes that limit HCV replication and predict therapeutic outcome. $468,750 total
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2024 | Co-Supervisor | Harnessing the potential of mRNA vaccines against Hepatitis C Virus | Doctor of Philosophy | Doctorate | Full Time | Mr John Henrik Johansson |
| 2024 | Co-Supervisor | Harnessing the potential of mRNA vaccines against Hepatitis C Virus | Doctor of Philosophy | Doctorate | Full Time | Mr John Henrik Johansson |
| 2022 | Principal Supervisor | CRISPR Screening Systems to Identify Novel Virus-Host Interactions and Innate Immune Pathways | Doctor of Philosophy | Doctorate | Full Time | Mr Xavier Bernard Montin |
| 2022 | Principal Supervisor | CRISPR Screening Systems to Identify Novel Virus-Host Interactions and Innate Immune Pathways | Doctor of Philosophy | Doctorate | Full Time | Mr Xavier Bernard Montin |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2021 - 2025 | Principal Supervisor | Understanding the impact of hypoxia and associated signalling pathways on ZIKV and DENV replication and innate antiviral responses | Doctor of Philosophy | Doctorate | Full Time | Miss Brooke Nyree Trowbridge |
| 2020 - 2023 | Principal Supervisor | Identification of dengue virus (DENV) NS1 protein residues involved in its cellular secretion and host factors involved in NS1 protein N-glycosylation | Doctor of Philosophy | Doctorate | Full Time | Mr Eng Kuan Brandon Tan |
| 2019 - 2023 | Principal Supervisor | CRISPR Activation as a Tool to Identify Anti-viral Host Factors | Doctor of Philosophy | Doctorate | Full Time | Miss Emily Nicole Kirby |
| 2018 - 2021 | Principal Supervisor | Molecular Characterisation of Flavivirus Interactions with the Host Innate Immune Response | Doctor of Philosophy | Doctorate | Full Time | Ms Rosa Cedar Coldbeck-Shackley |
| 2017 - 2020 | Co-Supervisor | Sterility and Immunogenicity of Gamma Irradiated Respiratory Viruses | Doctor of Philosophy | Doctorate | Full Time | Miss Eve Victoria Singleton |
| 2017 - 2022 | Principal Supervisor | Human Liver Organoids Culture as a Personalised Approach in Assessing HBV Infection and Cellular Responses | Doctor of Philosophy | Doctorate | Full Time | Dr Chuan Kok Lim |
| 2015 - 2021 | Principal Supervisor | Identification of Proviral and Host Restriction Factors that Impact the Flaviviridae Lifecycle | Doctor of Philosophy | Doctorate | Full Time | Mr Byron Shue |
| 2013 - 2018 | Principal Supervisor | The Novel Interacting Partners of Viperin and their Role in Establishing a Host Antiviral State | Doctor of Philosophy | Doctorate | Full Time | Ms Onruedee Khantisitthiporn |
| 2011 - 2015 | Principal Supervisor | Defining and Characterising the anti-HCV Actions of the Interferon-Induced Transmembrane Proteins | Doctor of Philosophy | Doctorate | Full Time | Miss Sumudu Kumari Narayana |
| 2011 - 2015 | Principal Supervisor | Dynamic Imaging of Hepatitis C Virus RNA Localisation and Traffic During Viral Replication | Doctor of Philosophy | Doctorate | Full Time | Mr Guillaume Fiches |
| 2010 - 2015 | Principal Supervisor | The Bystander Effect in Hepatitis C Virus Infection: Cellular Interactions Between Infected Cells and Uninfected Cells | Doctor of Philosophy | Doctorate | Full Time | Ms Kate Rebecca Muller |
| 2009 - 2015 | Principal Supervisor | Improving treatment predictors of HCV therapy and the impact of steatosis on the hepatocyte transcriptome and anti-HCV action of interferon | Doctor of Philosophy | Doctorate | Part Time | Prof Edmund Yee-Lai Tse |
| 2007 - 2012 | Co-Supervisor | Molecular Analysis of Acute and Chronic Duck Hepatitis B Virus (DHBV) Infections in Ducks | Doctor of Philosophy | Doctorate | Full Time | Miss Huey Low |
| 2007 - 2014 | Co-Supervisor | DEVELOPMENT AND ASSESSMENT OF NOVEL VACCINATION STRATEGIES FOR HEPATITIS B VIRUS INFECTION | Doctor of Philosophy | Doctorate | Full Time | Mr Devin Teoh |
| 2006 - 2011 | Principal Supervisor | Molecular Interactions Between Alcohol, Hepatitis C Virus and Interferon | Doctor of Philosophy | Doctorate | Full Time | Dr Erin McCartney |
| 2005 - 2010 | Co-Supervisor | Development of Antiviral Therapies for Hepatitis B Virus Infection | Doctor of Philosophy | Doctorate | Full Time | Miss Faseeha Noordeen |
| 2004 - 2008 | Co-Supervisor | Characterisation of the Events Involved in the Resolution of Acute Duck Hepatitis B Virus Infection | Doctor of Philosophy | Doctorate | Full Time | Dr Georget Reaiche |
| 2004 - 2010 | Principal Supervisor | Expression and function of osteopontin variants in HCV-related liver disease and hepato-cellular carcinoma | Doctor of Philosophy | Doctorate | Full Time | Dr Renee Phillips |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2015 - ongoing | Member | Lorne Infection and Immunity Conference | - | - |
| 2010 - ongoing | Member | Organising Committee International Symposium on HCV and Related Viruses | - | - |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2017 - ongoing | Associate Editor | Virology Journal | - | - |
| 2013 - ongoing | Advisory Board Member | Journal of Interferon and Cytokine Research | - | - |