Miss Matilda Jackson

Matilda Jackson
Early postdoctoral researcher
Adelaide Medical School
Faculty of Health and Medical Sciences

- Establish and characterise a mouse modelling the complete knockout of Iqsec2 to explore the role of Iqsec2 on development and plasticity of the brain.

- Investigate and functionally validate how mutations in IQSEC2 impact resulting protein function and localisation in vitro.

- Interrogate behavioural and seizure outcomes of mice modelling two most common ARX polyalanine expansion mutations.

- Study variants of unknown significance in ARX and IQSEC2.

Connect with me

Miss Matilda Jackson

- Establish and characterise a mouse modelling the complete knockout of Iqsec2 to explore the role of Iqsec2 on development and plasticity of the brain.

- Investigate and functionally validate how mutations in IQSEC2 impact resulting protein function and localisation in vitro.

- Interrogate behavioural and seizure outcomes of mice modelling two most common ARX polyalanine expansion mutations.

- Study variants of unknown significance in ARX and IQSEC2.

Current research areas:

  • Establish and characterise a mouse modelling the complete knockout of Iqsec2 to explore the role of Iqsec2 on development and plasticity of the brain.
  • Investigate and functionally validate how mutations in IQSEC2 impact resulting protein function and localisation in vitro.
  • Interrogate behavioural and seizure outcomes of mice modelling two most common ARX polyalanine expansion mutations.
  • Study variants of unknown significance in ARX and IQSEC2.

Appointments

Date Position Institution name
2014 Early postdoctoral researcher University of Adelaide
2010 - 2010 Research Assistant SA Pathology
2008 - 2010 Data Entry and Specimen Reception Abbott Pathology

Awards and Achievements

Date Type Title Institution Name Amount
2016 Award School of Medicine travel grant University of Adelaide $1000
2016 Award Robinson Research Institute travel grant University of Adelaide $550
2015 Award Women’s and Children’s Hospital Foundation 2015 Young Investigator Award Women's and Children's Hospital Foundation $2000
2015 Recognition Deans Commendation for PhD thesis University of Adelaide
2015 Achievement Accepted Abstract for Oral Presentation, WORLD Symposium
2015 Achievement Accepted Abstract for Oral Presentation, Australasian Gene and Cell Therapy Society
2015 Achievement Abstract Accepted for Oral Presentation, Genetics Society of AustralAsia
2013 Award Best student talk (second prize), Sciences 3 minute thesis competition University of Adelaide
2011 Award Sydney Tissue Engineering And Matrix (STEAM) Travel award Sydney Tissue Engineering And Matrix (STEAM) $500
2011 Achievement Accepted Abstract for Oral Presentation, Australian Society for Medical Reserach
2010 - 2014 Scholarship Australian Postgraduate Award University of Adelaide
2010 Achievement First Class Honours University of Adelaide
2006 - 2008 Recognition Member of the Golden Key Society Flinders University

Language Competencies

Language Competency
English Can read, write, speak, understand spoken and peer review

Education

Date Institution name Country Title
2010 - 2014 University of Adelaide Australia PhD
2009 - 2010 University of Adelaide Australia Honours
2006 - 2008 Flinders University Australia Undergraduate

Postgraduate Training

Date Title Institution Country
2010 - 2014 Alpha-L-iduronidase transduced mesenchymal stem cells as a treatment for CNS degeneration in Mucopolysaccharidosis type I mice University of Adelaide Australia

Certifications

Date Title Institution name Country
2017 Animal Ethics and Welfare Induction update University of Adelaide Australia
2011 Radiation Safety Training Course SA Pathology Australia
2011 Liquid Nitrogen Handling Course SA Pathology Australia
2010 Safe Handling of GMOs University of Adelaide Australia
2009 Occupational Health and Safety University of Adelaide Australia

Research Interests

Animal Behaviour, Animal Cell and Molecular Biology, Animal Developmental, Animal Neurobiology, Genetics, Neurogenetics

Journals

Year Citation
2017 Hinze, S., Jackson, M., Lie, S., Jolly, L., Field, M., Barry, S. ... Shoubridge, C. (2017). Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis. Translational Psychiatry, 7, 5, e1110-1-e-1110-11.
10.1038/tp.2017.81
2017 Jackson, M., Lee, K., Mattiske, T., Jaehne, E., Ozturk, E., Baune, B. ... Shoubridge, C. (2017). Extensive phenotyping of two ARX polyalanine expansion mutation mouse models that span clinical spectrum of intellectual disability and epilepsy. Neurobiology of Disease, 105, 245-256.
10.1016/j.nbd.2017.05.012
2017 Derrick Roberts, A., Jackson, M., Pyragius, C. & Byers, S. (2017). Substrate deprivation therapy to reduce glycosaminoglycan synthesis improves aspects of neurological and skeletal pathology in MPS I mice. Diseases, 5, 1, 5-1-5-16.
10.3390/diseases5010005
2017 Ewans, L., Field, M., Zhu, Y., Turner, G., Leffler, M., Dinger, M. ... Shoubridge, C. (2017). Gonadal mosaicism of a novel IQSEC2 variant causing female limited intellectual disability and epilepsy. European Journal of Human Genetics, 25, 6, 763-767.
10.1038/ejhg.2017.29
2015 Jackson, M., Derrick Roberts, A., Martin, E., Rout-Pitt, N., Gronthos, S. & Byers, S. (2015). Mucopolysaccharidosis enzyme production by bone marrow and dental pulp derived human mesenchymal stem cells. Molecular Genetics and Metabolism, 114, 4, 584-593.
10.1016/j.ymgme.2015.02.001
2014 Derrick-Roberts, A., Pyragius, C., Kaidonis, X., Jackson, M., Anson, D. & Byers, S. (2014). Lentiviral-mediated gene therapy results in sustained expression of β-Glucuronidase for up to 12 Months in the Gus mps/mps and up to 18 Months in the Gus tm(L175F)Sly mouse models of mucopolysaccharidosis type VII. Human Gene Therapy, 25, 9, 798-810.
10.1089/hum.2013.141

Conference Papers

Year Citation
2016 Jiang, Z., Rossouw, C., Reichstein, C., Macsai, C. E., Jackson, M. R., Derrick-Roberts, A. L. & Byers, S. (2016). Reduced chondrocyte proliferation and hypertrophy contribute to delayed endochondral bone formation in murine mucopolysaccharidosis VII. 12th Annual WORLD Symposium. San Diego, CA.
10.1016/j.ymgme.2015.12.306
2015 Jackson, M., Roberts, A. D., Gronthos, S. & Byers, S. (2015). IDURONIDASE TRANSDUCED MSCS IMPROVE THE BEHAVIOURAL DEFICITS IN MUCOPOLYSACCHARIDOSIS I MICE WITH LIMITED BIOCHEMICAL CORRECTIONS. 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA.
2015 Jackson, M., Robertsa, A., Gronthos, S. & Byers, S. (2015). α-l-Iduronidase transduced mesenchymal stem cells improve the behavioral deficits in mucopolysaccharidosis type I mice. 11th Annual Research Meeting WORLD Symposium of the Lysosomal Disease Network (WORLD). Orlando, FL.
10.1016/j.ymgme.2014.12.121

2016 – Channel 7 Children’s Research Foundation $65,000
Associate Investigator on grant titled: Investigating how mutations in IQSEC2 cause intellectual disability and severe early onset seizures in children using a mouse modelling the knockout of Iqsec2 (Reference 161263)

University of Adelaide, School of Biological Sciences
Mentor to PhD student Karagh Loring, 2017-current.
Mentored honours student Oliver Dearsley, First Class, 2015.

University of Adelaide, School of Paediatrics
Supervised two 3rd year placement students for 13 week Research Project in Reproductive Health Semester 1, 2017
Supervised one 3rd year placement student for 13 week Research Project in Reproductive Health Semester 1, 2016, High Distinction.

Memberships

Date Role Membership Country
2016 - ongoing Member Australasian Neuroscience Society Australia
2009 - 2014 Representative Matrix Biology Society of Australia and New Zealand Australia

Committee Memberships

Date Role Committee Institution Country
2016 - ongoing Representative Adelaide Health and Medical Sciences Animal Users group University of Adelaide Australia
Position
Early postdoctoral researcher
Phone
83136148
Campus
North Terrace
Building
Adelaide Health and Medical Sciences Building
Room Number
WS8062.48
Org Unit
Paediatrics and Reproductive Health

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