Marcus Wagstaff

Marcus Wagstaff

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

A/Professor Marcus Wagstaff BSc, MBBS, PhD, FRCS(Plast), FRACS

Marcus is a Specialist Plastic and Reconstructive Surgeon, Head of Unit of the Adult Burns Service at the Royal Adelaide Hospital (RAH), Associate Professor affiliated to the University of Adelaide Faculty of Health and Medical Sciences, and Head of the RAH Skin Engineering Laboratory.

He obtained his medical degree and PhD in molecular pathology at University College London, trained in plastic and reconstructive surgery in the UK, and has been working as a consultant at the RAH since 2010.

His surgical interests include breast reconstruction after cancer, burns surgery, microsurgery, cosmetic breast surgery, body contouring, hand surgery, skin cancer excision and reconstruction, and trauma.

He has research interests in skin culture, wounds, dermal substitutes, and scar management. He is a qualified PhD supervisor for the University of Adelaide and an examiner for the FRACS exam.

Whilst providing an essential epidermal cell expansion and delivery service to supplement skin grafts in burns patients of South Australia, the RAH Skin Engineering Laboratory carries out focused translational research on laboratory-grown autologous composite skin culture (dermis and epidermis). The work of Dr Bronwyn Dearman is pioneering this tissue engineering technology for use in extensive burn-related and surgical wounds, with the goal of negating the need for surgical skin grafts.

A/Prof Wagstaff's doctoral research approached the question of whether overexpression of the heat shock proteins can protect neurons from the stresses of heat shock, ischaemia and apoptotic stimuli, an enquiry that demanded an understanding of the principles and problems associated with gene therapy - including vectors, delivery, and transgene expression -  as well as knowledge of herpes simplex virology, gene activation, the cellular response to stress and the role of molecular chaperones. As a PhD candidate, A/Prof Wagstaff became experienced in both basic and specialised molecular and cellular biology and virology techniques and developed more general research skills such as protocol development, data compilation, statistical analysis and interpretation, and manuscript preparation.

A/Prof Wagstaff has worked collaboratively with Prof John Greenwood in the Burns Unit of the Royal Adelaide Hospital in developing a novel dermal scaffold for cultured composite skin application in burns patients. During its development, they conducted the following four HREC approved case series:

Year Series Overview Project Details

2012

Short term implantation of novel biodegradable polyurethane foam in a randomised controlled trial as a negative pressure wound therapy dressing for decubitus ulcers.
  • 16 patients
  • 20 ulcers
2013 Long term implantation of novel biodegradable polyurethane foam (biodegradable temporising matrix – BTM) as a dermal scaffold for free flap donor site reconstruction.
  • 10 patients
2014 Long term implantation of an optimised, modified BTM as a dermal scaffold for free flap donor site reconstruction.
  • 10 patients
2014 Use of the BTM as a dermal scaffold for major burn reconstruction
  • 5 patients

  • Appointments
    Date Position Institution name
    2020 - ongoing Clinical Associate Professor University of Adelaide
    2020 - ongoing Head of Unit Royal Adelaide Hospital
    2017 - ongoing Consultant Plastic and Reconstructive Surgeon Advanced Plastic and Cosmetic Surgery
    2012 - ongoing Consultant Plastic and Reconstructive Staff Specialist Royal Adelaide Hospital
    2011 - 2012 Senior Registrar / Supervised Consultant Royal Adelaide Hospital
    2010 - 2011 Microsurgical Fellow Royal Adelaide Hospital

  • Language Competencies
    Language Competency
    English Can read, write, speak, understand spoken and peer review

  • Education
    Date Institution name Country Title
    2012 Royal Australasian College of Surgeons Australia FRACS in Plastic Surgery
    2009 Postgraduate Medical Education and Training Board (United Kingdom) United Kingdom Certificate of Completion of Training in Plastic Surgery
    2009 Royal College of Surgeons of England United Kingdom FRCS (Plast)
    2002 Royal College of Surgeons of England United Kingdom MRCS
    1999 University College London United Kingdom MBBS
    1997 University College London United Kingdom PhD (Molecular Pathology)
    1994 University College London United Kingdom Bachelor of Science (Immunology) with First Class Honours

  • Research Interests
    Surgical and Health Systems Innovation Surgery

  • Journals
    Year Citation
    2023 Concannon, E., Damkat-Thomas, L., Rose, E., Coghlan, P., Solanki, N., & Wagstaff, M. (2023). Use of a synthetic dermal matrix for reconstruction of 55 patients with non-graftable wounds and management of complications. Journal of Burn Care & Research, 44(4), 894-904.
    DOI Scopus2 WoS2 Europe PMC2
    2023 Bedrikovetski, S., Traeger, L., Jay, A. A., Oehler, M. K., Cho, J., Wagstaff, M., . . . Sammour, T. (2023). Is preoperative sarcopenia associated with postoperative complications after pelvic exenteration surgery?. Langenbeck's archives of surgery, 408(1), 12 pages.
    DOI
    2023 Lo, C. H., Wagstaff, M. J. D., Barker, T. M., Damkat-Thomas, L., Salerno, S., Holden, D., . . . Cleland, H. (2023). Long-term scarring outcomes and safety of patients treated with NovoSorb<sup>Ⓡ</sup> Biodegradable Temporizing Matrix (BTM): An observational cohort study. JPRAS Open, 37, 42-51.
    DOI Scopus1 Europe PMC1
    2023 Wagstaff, M. (2023). Burns workforce planning. Australasian Journal of Plastic Surgery, 6(1).
    DOI
    2023 De Decker, I., Klotz, T., Vu, P., Hoeksema, H., De Mey, K., Beeckman, A., . . . Claes, K. E. Y. (2023). Influence of Moisturizers on Skin Microcirculation: An Assessment Study Using Laser Speckle Contrast Imaging. Journal of Personalized Medicine, 13(10), 1507.
    DOI
    2023 Concannon, E., Damkat Thomas, L., Kerr, L., Damkat, I., Reddi, B., Greenwood, J. E., . . . Wagstaff, M. J. D. (2023). Review of Indications for Endotracheal Intubation in Burn Patients with Suspected Inhalational Injury. EUROPEAN BURN JOURNAL, 4(2), 163-172.
    DOI
    2022 Kuang, B., Pena, G., Cowled, P., Fitridge, R., Greenwood, J., Wagstaff, M., & Dawson, J. (2022). Use of Biodegradable Temporising Matrix (BTM) in the reconstruction of diabetic foot wounds: A pilot study.. Scars, burns & healing, 8, 20595131221122272.
    DOI Europe PMC1
    2022 Barker, T., Wagstaff, M., Ricketts, S., & Bruscino-Raiola, F. (2022). Use of a bilayer biodegradable synthetic dermal matrix for the management of defects arising from necrotising fasciitis. Journal of Wound Care, 31(9), 724-732.
    DOI
    2022 Lo, C. H., Brown, J. N., Dantzer, E. J. G., Maitz, P. K. M., Vandervord, J. G., Wagstaff, M. J. D., . . . Cleland, H. (2022). Wound healing and dermal regeneration in severe burn patients treated with NovoSorb® Biodegradable Temporising Matrix: A prospective clinical study. Burns, 48(3), 529-538.
    DOI Scopus19 WoS15 Europe PMC6
    2022 Klotz, T., Ibrahim, A., Maddern, G., Caplash, Y., & Wagstaff, M. (2022). Devices measuring transepidermal water loss: A systematic review of measurement properties.. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 28(4), 497-539.
    DOI Scopus7 WoS4 Europe PMC5
    2022 Traeger, L., Bedrikovetski, S., Oehler, M. K., Cho, J., Wagstaff, M., Harbison, J., . . . Sammour, T. (2022). Short-term outcomes following development of a dedicated pelvic exenteration service in a tertiary centre.. ANZ J Surg, 92(10), 2620-2627.
    DOI Scopus5 WoS3 Europe PMC1
    2021 Stefani, K., Wagstaff, M. J. D., Damkat, I., & Greenwood, J. E. (2021). Mortality data 2004–2019: an audit of the Royal Adelaide Hospital Adult Burn Service. ANZ Journal of Surgery, 91(1-2), 77-82.
    DOI Scopus2
    2021 Schmitt, B., Heath, K., Kurmis, R., Klotz, T., Wagstaff, M. J. D., & Greenwood, J. (2021). Early physiotherapy experience with a biodegradable polyurethane dermal substitute: Therapy guidelines for use. Burns, 47(5), 1074-1083.
    DOI Scopus6 WoS4 Europe PMC1
    2021 Klotz, T., Maddern, G., Caplash, Y., & Wagstaff, M. (2021). Devices measuring transepidermal water loss of the skin. JBI Evidence Synthesis, 19(10), 2893-2903.
    DOI Scopus1 WoS1 Europe PMC1
    2019 Damkat-Thomas, L., Greenwood, J. E., & Wagstaff, M. J. D. (2019). A Synthetic Biodegradable Temporising Matrix in Degloving Lower Extremity Trauma Reconstruction: A Case Report. Plastic and Reconstructive Surgery - Global Open, 7(4), 4 pages.
    DOI Scopus26 WoS18 Europe PMC12
    2019 Wagstaff, M. J. D., Salna, I. M., Caplash, Y., & Greenwood, J. E. (2019). Biodegradable Temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series. Burns Open, 3(1), 12-30.
    DOI Scopus37
    2018 Greenwood, J. E., Schmitt, B. J., & Wagstaff, M. J. D. (2018). Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury. Burns Open, 2(1), 17-34.
    DOI Scopus52
    2017 Wagstaff, M. J., Caplash, Y., & Greenwood, J. E. (2017). Reconstruction of an Anterior Cervical Necrotizing Fasciitis Defect Using a Biodegradable Polyurethane Dermal Substitute.. Eplasty, 17, e3.
    Europe PMC10
    2016 Greenwood, J. E., Wagstaff, M. J. D., Rooke, M., & Caplash, Y. (2016). Reconstruction of Extensive Calvarial Exposure After Major Burn Injury in 2 Stages Using a Biodegradable Polyurethane Matrix.. Eplasty, 16, e17.
    Europe PMC15
    2016 Iyer, K., Dearman, B. L., Wagstaff, M. J., & Greenwood, J. E. (2016). A Novel Biodegradable Polyurethane Matrix for Auricular Cartilage Repair: An In Vitro and In Vivo Study. Journal of Burn Care and Research, 37(4), e353-e364.
    DOI Scopus9 WoS9 Europe PMC5
    2016 Smith, N. W. S., Overland, J., & Wagstaff, M. (2016). Informed consent practices by junior medical officers: A cross-sectional study. ANZ Journal of Surgery, 86(1-2), 10-11.
    DOI Scopus2 WoS2
    2015 Mistry, R., Caplash, Y., Giri, P., Kearney, D., & Wagstaff, M. (2015). Thoracic outlet syndrome following breast implant rupture. Plastic and reconstructive surgery. Global open, 3(3), e331-1-e331-4.
    DOI Scopus2 WoS1 Europe PMC1
    2015 Wagstaff, M., Schmitt, B., Coghlan, P., Finkemeyer, J., Caplash, Y., & Greenwood, J. (2015). A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites: a pilot study. Eplasty, 15, 102-118.
    Europe PMC15
    2015 Wagstaff, M., Schmitt, B., Caplash, Y., & Greenwood, J. (2015). Free Flap Donor Site Reconstruction: A Prospective Case Series Using an Optimized Polyurethane Biodegradable Temporizing Matrix.. Eplasty, 15, 231-248.
    Europe PMC11
    2014 Wagstaff, M., Driver, S., Coghlan, P., & Greenwood, J. (2014). A randomized, controlled trial of negative pressure wound therapy of pressure ulcers via a novel polyurethane foam. Wound Repair and Regeneration, 22(2), 205-211.
    DOI Scopus30 WoS26 Europe PMC15
    2013 Mistry, R., Tsimiklis, C., Wagstaff, M., Abou-Hamden, A., & Caplash, Y. (2013). Secondary Reconstruction of Recurrent Primary Intraosseous Meningioma of the Calvarium Using a Fasciocutaneous Anterolateral Thigh Free Flap. Neuroscience and Medicine, 04(04), 280-283.
    DOI
    2012 Pilkington, K., Wagstaff, M., & Greenwood, J. (2012). Prevention of gastrointestinal bleeding due to stress ulceration: a review of current literature. Anaesthesia and Intensive Care, 40(2), 253-259.
    DOI Scopus17 WoS17 Europe PMC11
    2012 Solanki, N. S., Greenwood, J. E., Wagstaff, M. J. D., & Franchi, B. F. A. L. (2012). Length of stay of elderly patients in an acute burns unit: has the pilot appointment of a geriatrician to the service made a difference?. Journal of Burn Care and Research, 33(3), e179.
    DOI Scopus2 WoS2 Europe PMC1
    2012 Greenwood, J. E., Wagstaff, M. J. D., Mackie, I. P., & Mustoe, T. A. (2012). Silicone action in the open wound: a hypothesis. Journal of Burn Care and Research, 33(1), e17-e20.
    DOI Scopus5 WoS3 Europe PMC2
    2011 Chang, A. C., Watson, K. M., Aston, T. L., Wagstaff, M. J., & Greenwood, J. E. (2011). Depilatory wax burns: experience and investigation.. Eplasty, 11, e25.
    Europe PMC1
    2010 Rozen, W. M., Whitaker, I. S., Audolfsson, T., Jakobsson, O. P., Wagstaff, M. J. D., & Acosta, R. (2010). Banking a DIEP flap in high-risk patients: A new technique during unilateral DIEP harvest. Plastic and Reconstructive Surgery, 125(3), 114E-115E.
    DOI Scopus2 WoS5 Europe PMC1
    2010 Wagstaff, M. J. D. (2010). BASO/BAPRAS interface fellowship in oncoplastic surgery of the breast at Sheffield teaching hospitals NHS trust. Annals of Plastic Surgery, 65(6), 517-518.
    DOI
    2010 Rozen, W. M., Whitaker, I. S., Wagstaff, M. J. D., Audolfsson, T., & Acosta, R. (2010). Buried free flaps for breast reconstruction: A new technique using the cook-swartz implantable doppler probe for postoperative monitoring. Plastic and Reconstructive Surgery, 125(4), 171E-172E.
    DOI Scopus10 WoS6 Europe PMC5
    2010 Acosta, R., Enajat, M., Rozen, W. M., Smit, J. M., Wagstaff, M. J. D., Whitaker, I. S., & Audolfsson, T. (2010). Performing two DIEP flaps in a working day: an achievable and reproducible practice. Journal of Plastic, Reconstructive and Aesthetic Surgery, 63(4), 648-654.
    DOI Scopus29 WoS25 Europe PMC13
    2010 Rozen, W. M., Wagstaff, M. J. D., Grinsell, D., Le Roux, C. M., & Ashton, M. W. (2010). The course of anterolateral thigh perforators does not correlate between sides of the body: The role for preoperative imaging. Plastic and Reconstructive Surgery, 125(3), 132E-134E.
    DOI Scopus4 WoS2 Europe PMC2
    2009 Mavrogordato, A. E., Wagstaff, M. J. D., Fletcher, A. J. P., Wilson, D. I., & Jayamaha, J. E. L. (2009). A novel method to treat hyperthermia in a burns case: Use of a catheter-based heat exchange system. Burns, 35(1), 141-145.
    DOI Scopus8 WoS4 Europe PMC4
    2009 Wagstaff, M. J. D., Rozen, W. M., Whitaker, I. S., Schneider, T. N., Audolfsson, T., & Acosta, R. (2009). Kirschner wires: a novel technique to assist abdominal closure utilising the viscoelastic properties of skin. Journal of Plastic, Reconstructive and Aesthetic Surgery, 62(5), E115-E116.
    DOI Scopus2 WoS2 Europe PMC1
    2009 Rozen, W. M., Ashton, M. W., Whitaker, I. S., Wagstaff, M. J. D., & Acosta, R. (2009). The financial implications of computed tomographic angiography in diep flap surgery: A cost analysis. Microsurgery, 29(2), 168-169.
    DOI Scopus32 WoS29 Europe PMC19
    2009 Wagstaff, M. J. D., Rozen, W. M., Whitaker, I. S., Enajat, M., Audolfsson, T., & Acosta, R. (2009). Perineal and posterior vaginal wall reconstruction with superior and inferior gluteal artery perforator flaps. Microsurgery, 29(8), 626-629.
    DOI Scopus53 WoS44 Europe PMC29
    2009 Audolfsson, T., Rozen, W. M., Wagstaff, M. J. D., Whitaker, I. S., & Acosta, R. (2009). A reliable and aesthetic technique for cephalic vein harvest in DIEP flap surgery. Journal of Reconstructive Microsurgery, 25(5), 319-321.
    DOI Scopus8 WoS9 Europe PMC3
    2007 Wagstaff, M. J. D., Shah, M., McGrouther, D. A., & Latchman, D. S. (2007). The heat shock proteins and plastic surgery. Journal of Plastic, Reconstructive and Aesthetic Surgery, 60(9), 974-982.
    DOI Scopus15 WoS13 Europe PMC6
    2006 Milner, C. S., Wagstaff, M. J. D., & Rose, G. K. (2006). Compartment syndrome of multiple limbs: An unusual presentation. Journal of Plastic, Reconstructive and Aesthetic Surgery, 59(11), 1251-1252.
    DOI Scopus5 WoS4 Europe PMC3
    2006 Wagstaff, M. J. D., Sankar, T. K., & Ward, D. J. (2006). Describing the 'dog ear' - a novel method. ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 88(4), 415-416.
    DOI
    2004 Wagstaff, M. J. D., Raurell, A., & Perks, A. G. B. (2004). Multicentric extra-abdominal desmoid tumours. British Journal of Plastic Surgery, 57(4), 362-365.
    DOI Scopus16 WoS11 Europe PMC10
    1999 Brar, B. K., Stephanou, A., Wagstaff, M. J. D., Coffin, R. S., Marber, M. S., Engelmann, G., & Latchman, D. S. (1999). Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress. Journal of Molecular and Cellular Cardiology, 31(1), 135-146.
    DOI Scopus117 WoS108 Europe PMC78
    1999 Wagstaff, M. J. D., Collaço-Moraes, Y., Smith, J., De Belleroche, J. S., Coffin, R. S., & Latchman, D. S. (1999). Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector. Journal of Biological Chemistry, 274(8), 5061-5069.
    DOI Scopus195 WoS188 Europe PMC145
    1998 Wagstaff, M. J. D. (1998). Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis. European Journal of Neuroscience, 10(11), 3343-3350.
    DOI Scopus35 WoS33 Europe PMC25
    1998 Coffin, R. S., Thomas, S. K., Thomas, N. S. B., Lilley, C. E., Pizzey, A. R., Griffiths, C. H., . . . Latchman, D. S. (1998). Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry. Gene Therapy, 5(5), 718-722.
    DOI Scopus34 WoS29 Europe PMC19
    1998 Wagstaff, M. J. D., Lilley, C. E., Smith, J., Robinson, M. J., Coffin, R. S., & Latchman, D. S. (1998). Gene transfer using a disabled herpes virus vector containing the EMCV IRES allows multiple gene expression in vitro and in vivo. Gene Therapy, 5(11), 1566-1570.
    DOI Scopus26 WoS22 Europe PMC12
    1996 Wagstaff, M. J. D., Collaço-Moraes, Y., Aspey, B. S., Coffin, R. S., Harrison, M. J. G., Latchman, D. S., & De Belleroche, J. S. (1996). Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs. Molecular Brain Research, 42(2), 236-244.
    DOI Scopus52 WoS54 Europe PMC43
    1995 VYAKARNAM, A., MATEAR, P. M., MARTIN, S. J., & WAGSTAFF, M. (1995). TH1 CELLS SPECIFIC FOR HIV-1 GAG P24 ARE LESS EFFICIENT THAN TH0 CELLS IN SUPPORTING HIV REPLICATION, AND INHIBIT VIRUS-REPLICATION IN TH0 CELLS. IMMUNOLOGY, 86(1), 85-96.
    WoS34 Europe PMC25

  • Books
    Year Citation
    2011 Raftery, A. T., Delbridge, M. S., & Wagstaff, M. J. D. (2011). Churchill's Pocketbook of Surgery E-Book. Elsevier Health Sciences.

  • Book Chapters
    Year Citation
    2016 Greenwood, J., & Wagstaff, M. (2016). The use of Biodegradable Polyurethane in the Development of Dermal Scaffolds. In S. Cooper, & J. Guan (Eds.), Advances in Polyurethane Biomaterials (pp. 631-662). United Kingdom: Elsevier.
    DOI Scopus8
    2010 Wagstaff, M. J. D., Reed, M. W. R., & Caddy, C. M. (2010). Breast reconstruction. In Management of Breast Cancer in Older Women (pp. 213-229). Springer London.
    DOI
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