Mahesh Umapathysivam
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
2024 J Tan, L Ephraums, J Inglis, H Nguyen, M Umapathysivam et al. A cross-sectional study of capillary blood ketone concentrations in heart failure based on sodium-glucose co-transporter-2 inhibitor use and heart failure type Heart, Lung Circulation
2024 G Wittert & M Umapathysivam Testosterone and the prevention of type 2 diabetes mellitus: Therapeutic implications from recent trials, Current Opinion in Endocrinology, Diabetes and Obesity
2024 R Jalleh, M Umapathysivam et al Gastric emptying during and following resolution of moderate diabetic ketoacidosisin type 1 diabetes: a case series. BMJ Open Diabetes Research & Care
2024 M Umapathysivam et al SGLT2 Inhibitor associated ketoacidosis vs Type 1 diabetes associated ketoacidosis. JAMA Network Open. 2024
2024 M Umapathysivam et al. Euglycemic ketoacidosis in two Patients without Diabetes After Introduction of Sodium Glucose Co-transporter 2 inhibition, Diabetes Care. 2024
2023 R Jalleh, M Umapathysivam, M Plummer, M Horowitz. Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass – a systematic review. Reviews in Endocrine and Metabolic disorders
2023 A Hayes, M Stowasser, M Umapathysivam, et al. Approach to the patient: Reninoma, Journal of clinical endocrinology 2023
2023 Umapathysivam et al Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists. Preprint. Medarchive (Under review at Nat Metabolism– corrections required)
2022 Intraprocedural cortisol testing improves adrenal vein cannulation success and diagnostic accuracy in assessment of primary aldosteronism, in a medium throughput centre. M Umapathysivam et al. Journal of Human Hypertension
2022 Effects of Androgens on glucose metabolism M Umapathysivam, M Grossman, G Wittert. Clinical Endocrinology & Metabolism
2022 Letter to the Editor: Response to Hamblin et al Body Mass index is inversely associated with capillary ketones at time of colonoscopy: Implications for SGLT2i use. M Umapathysivam et al. Clinical Endocrinology
2022 Accidental exposure to glimepiride from adulterated medication resulting in severe hypoglycaemia. A Hayes, M Umapathysivam, D Torpy EDM case reports
2021 Response to Dahl et al: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes. M Horowitz…M Umapathysivam et al., Diabetes Obesity and Metabolism 2021
2019 Type 2 diabetes risk alleles in PAM cause pancreatic beta-cell dysfunction through direct effects on insulin availability and secretion. S Thomsen, A Raimondo, B Hastory, … M Umapathysivam, … MI McCarthy A Gloyn et al. Nature genetics 2019
2013 The Effect of Prolonged Glucagon-Like Peptide-1 Receptor Stimulation on Gastric Emptying and Glycemia. M Umapathysivam, M Lee, et al Diabetes 2013
2013 The effect of exogenous glucose – dependent insulinotropic polypeptide in combination with glucagon-like peptide-1 on glycaemia in critically ill patients, M Lee, JD Fraser,K Sundararajan, M Umapathysivam, … M Horowitz, A Deane et al Diabetes Care. 2013
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Journals
Year Citation 2025 Jalleh, R. J., Marathe, C. S., Rayner, C. K., Jones, K. L., Umapathysivam, M. M., Wu, T., . . . Horowitz, M. (2025). Physiology and Pharmacology of Effects of GLP-1-based Therapies on Gastric, Biliary and Intestinal Motility. Endocrinology (United States), 166(1), 14 pages.
2025 Tan, J. Y., Ephraums, L. A., Inglis, J. M., Nguyen, H. T. T., Umapathysivam, M. M., Simpson, N. J., . . . Thynne, T. R. J. (2025). A Cross-Sectional Study of Capillary Blood Ketone Concentrations in Heart Failure Based on Sodium-Glucose Co-Transporter-2 Inhibitor Use and Heart Failure Type. Heart Lung and Circulation, 34(1), 34-39.
2025 Soares, G. H., Haag, D., Bastos, J. L., Mejia, G., & Jamieson, L. (2025). Triple Jeopardy in Oral Health: Additive Effects of Immigrant Status, Education, and Neighborhood. JDR Clinical & Translational Research, 10(1), 54-63.
2024 Eger, A., Aguirre, J. D., Altamirano, M., Arafeh‑Dalmau, N., Arroyo, N. L., Bauer‑Civiello, A. M., . . . Vergès, A. (2024). Correction to: The Kelp Forest Challenge: A collaborative global movement to protect and restore 4 million hectares of kelp forests (Journal of Applied Phycology, (2023), 10.1007/s10811-023-03103-y). Journal of Applied Phycology, 36(2), 965-967.
2024 Wittert, G., & Umapathysivam, M. M. (2024). Testosterone and the prevention of type 2 diabetes mellitus: therapeutic implications from recent trials. Current Opinion in Endocrinology, Diabetes and Obesity, 31(6), 243-248.
2024 Jalleh, R. J., Plummer, M. P., Marathe, C. S., Umapathysivam, M. M., Quast, D. R., Rayner, C. K., . . . Nauck, M. A. (2024). Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide. The Journal of clinical endocrinology and metabolism, 110(1), 1-15.
Scopus2 Europe PMC12024 Luppino, M. D., Nguyen, H., Smale, M., Madigan, R., Burt, M. G., & Umapathysivam, M. M. (2024). Propofol-induced transient arginine vasopressin deficiency. Endocrinology, Diabetes and Metabolism Case Reports, 2024(4), 5 pages.
2024 Umapathysivam, M. M., Morgan, B., Inglis, J. M., Meyer, E., Liew, D., Thiruvenkatarajan, V., & Jesudason, D. (2024). SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Network Open, 7(3), E242744.
Scopus2 Europe PMC12024 Jalleh, R. J., Phillips, L., Umapathysivam, M. M., Jones, K. L., Marathe, C. S., Watson, L. E., . . . Horowitz, M. (2024). Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series. BMJ Open Diabetes Research & Care, 12(2), e003854-1-e003854-4.
2024 Beggs, P. J., Trueck, S., Linnenluecke, M. K., Bambrick, H., Capon, A. G., Hanigan, I. C., . . . Zhang, Y. (2024). The 2023 report of the MJA-Lancet Countdown on health and climate change: sustainability needed in Australia's health care sector. Medical Journal of Australia, 220(6), 282-303.
Scopus8 Europe PMC32024 Hayes, A. G., Stowasser, M., Umapathysivam, M. M., Falhammar, H., & Torpy, D. J. (2024). Approach to the Patient: Reninoma. Journal of Clinical Endocrinology and Metabolism, 109(2), e809-e816.
Scopus4 WoS1 Europe PMC42024 Umapathysivam, M. M., Gunton, J., Stranks, S. N., & Jesudason, D. (2024). Euglycemic Ketoacidosis in Two Patients Without Diabetes After Introduction of Sodium–Glucose Cotransporter 2 Inhibitor for Heart Failure With Reduced Ejection Fraction. Diabetes Care, 47(1), 140-143.
Scopus18 Europe PMC62024 Tan, S., Vuong, A., Kovoor, J., Gupta, A., Chan, W. O., Umapathysivam, M., . . . Bacchi, S. (2024). Beware of little expenses: Low-value endocrinological blood tests in geriatric medical inpatients. Australasian Journal on Ageing, 43(1), 211-214.
2023 Jalleh, R. J., Umapathysivam, M. M., Plummer, M. P., Deane, A., Jones, K. L., & Horowitz, M. (2023). Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass – a systematic review. Reviews in Endocrine and Metabolic Disorders, 24(6), 1075-1088.
Scopus7 Europe PMC42023 Umapathysivam, M. M., Morgan, B., Bischoff, C., Hayes, A., Wilks, M., Stowasser, M., & Torpy, D. J. (2023). Intraprocedural cortisol testing improves adrenal vein cannulation success and diagnostic accuracy in assessment of primary aldosteronism, in a medium throughput centre. Journal of Human Hypertension, 37(9), 783-787.
Scopus6 WoS2 Europe PMC22023 Thiruvenkatarajan, V., Inglis, J. M., Meyer, E., Umapathysivam, M. M., Nanjappa, N., Van Wijk, R., & Jesudason, D. (2023). Peri-colonoscopy Implications of Sodium-Glucose Cotransporter-2 Inhibitor Therapy: A Mini-review of Available Evidence. Canadian Journal of Diabetes, 47(3), 287-291.
Scopus1 Europe PMC12023 Umapathysivam, M. M., Inglis, J. M., Morgan, B., Meyer, E., Thiruvenkatarajan, V., & Jesudason, D. (2023). Letter to the Editor: Response to Hamblin et al body mass index is inversely associated with capillary ketones at the time of colonoscopy: Implications for SGLT2i use. Clinical Endocrinology, 98(3), 449-451.
Scopus2 WoS1 Europe PMC12023 Leske, M., Koczwara, B., Morris, J., & Beatty, L. (2023). Modality preferences for health behaviour interventions for post-treatment cancer survivors: a theoretical investigation. Supportive Care in Cancer, 31(2), 10 pages.
Scopus2 Europe PMC12022 Umapathysivam, M., Grossmann, M., & Wittert, G. A. (2022). Effects of androgens on glucose metabolism. Best Practice and Research: Clinical Endocrinology and Metabolism, 36(5), 1-13.
Scopus6 WoS2 Europe PMC22022 Hayes, A. G., Umapathysivam, M. M., & Torpy, D. J. (2022). Accidental exposure to glimepiride from adulterated medication resulting in severe hypoglycaemia. Endocrinology, Diabetes and Metabolism Case Reports, 2022(1), 4 pages.
Scopus12021 Tunstall, E. (2021). The Paradox of the Valentine Thomas Affair: English Diplomacy, Royal Correspondence and the Elizabethan Succession. PARERGON, 38(1), 65-87.
2021 Horowitz, M., Rayner, C. K., Marathe, C. S., Wu, T., Umapathysivam, M., & Jones, K. L. (2021). Response to Dahl et al: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism, 23(10), 2411-2413.
Scopus4 WoS2 Europe PMC32020 Al-Memar, M., Bobdiwala, S., Fourie, H., Mannino, R., Lee, Y. S., Smith, A., . . . MacIntyre, D. A. (2020). The association between vaginal bacterial composition and miscarriage: a nested case–control study. BJOG: An International Journal of Obstetrics and Gynaecology, 127(2), 264-274.
Scopus102 Europe PMC612020 Bennett, P. R., Brown, R. G., & MacIntyre, D. A. (2020). Vaginal Microbiome in Preterm Rupture of Membranes. Obstetrics and Gynecology Clinics of North America, 47(4), 503-521.
Scopus52 Europe PMC302018 Thomsen, S. K., Raimondo, A., Hastoy, B., Sengupta, S., Dai, X. Q., Bautista, A., . . . Gloyn, A. L. (2018). Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics, 50(8), 1122-1131.
Scopus49 WoS41 Europe PMC412014 Umapathysivam, M., Lee, M., Jones, K., Annink, C., Cousins, C., Trahair, L., . . . Deane, A. (2014). Comparative effects of prolonged and intermittent stimulation of the glucagon- like peptide 1 receptor on gastric emptying and glycemia. Diabetes, 63(2), 785-790.
Scopus133 WoS95 Europe PMC782013 Lee, M., Fraser, J., Chapman, M., Sundararajan, K., Umapathysivam, M., Summers, M., . . . Deane, A. (2013). The effect of exogenous glucose-dependent insulinotropic polypeptide in combination with glucagon-like peptide-1 on glycemia in the critically ill. Diabetes Care, 36(10), 3333-3336.
Scopus16 WoS16 Europe PMC111978 HEYMA, P., LARKINS, R. G., STOCKIGT, J. R., & CAMPBELL, D. G. (1978). FORMATION OF TRI-IODOTHYRONINE AND REVERSE TRI-IODOTHYRONINE FROM THYROXINE IN ISOLATED RAT RENAL TUBULES. CLINICAL SCIENCE AND MOLECULAR MEDICINE, 55(6), 567-572.
WoS21 Europe PMC51968 OWEN, J. A., & CAMPBELL, D. G. (1968). A COMPARISON OF PLASMA ELECTROLYTE AND UREA VALUES IN HEALTHY PERSONS AND IN HOSPITAL PATIENTS. CLINICA CHIMICA ACTA, 22(4), 611-&.
WoS51 Europe PMC38 -
Book Chapters
Year Citation 2023 Goldhahn, J. (2023). GHOSTHAWK WORLDINGS: RAPTOR HARUSPICY DURING THE NORTH EUROPEAN BRONZE AGE. In The Art and Archaeology of Human Engagements with Birds of Prey: From Prehistory to the Present (pp. 53-68). Bloomsbury Publishing Plc.
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Conference Papers
Year Citation 2024 Mohammadi, B., Hong, Y., Qi, Y., Wu, Q., Pan, S., & Shi, J. Q. (2024). Augmented Commonsense Knowledge for Remote Object Grounding. In Proceedings of the AAAI Conference on Artificial Intelligence Vol. 38 (pp. 4269-4277). Online: Association for the Advancement of Artificial Intelligence (AAAI).
DOI Scopus52024 Araldi, E., Umapathysivam, M. M., Hastoy, B., Dawed, A. Y., Vatandaslar, H., Sengupta, S., . . . Gloyn, A. L. (2024). Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists. In FEBS OPEN BIO Vol. 14 (pp. 467). WILEY. 2019 Sengupta, S., Bonnycastle, L. L., Hastoy, B., Grotz, A., Umapathysivam, M. M., Raimondo, A., . . . Gloyn, A. L. (2019). Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus. In DIABETES Vol. 68 (pp. 2 pages). CA, San Francisco: AMER DIABETES ASSOC.
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Preprint
Year Citation 2022 Trigg, J., Shen, D., Morris, J., & Blunt, J. (2022). Characteristics of Aboriginal and Torres Strait Islander Smokers Exposed to Anti-smoking Marketing in South Australia.
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2023 Do carriers of type 2 diabetes risk alleles in PAM have accelerated gastric emptying? Principal investigator. Diabetes Australia Project Grant. (Y24G-UMAM) $57,352.
2023 SGLT2i induced DKA RCT of fluid rate. Principal Investigator. Australian Diabetes Society/Astrazeneca Grant. $20,000
2022 Effect of subcutaneous (sc) semaglutide on gastric emptying measured using the 'gold standard' technique, scintigraphy, in type 2 diabetes (T2D). Associate Investigator. Diabetes Australia Project Grant. $70,000.
2021 Effect of rate of onset of hypoglycaemia on counter regulatory response in type 1 diabetes. Principal Investigator. Diabetes Australia Project Grant. (Y22G-UMAM) $67,000
2018 Diabetes physiology stream £5406 Principal Investigator. Oxford Biomedical Research Centre Pump Priming Grant (approx. $10,000)
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Interactions between sleep, circadian rhythm, dysglycaemia and sex steroids Doctor of Philosophy Doctorate Full Time Mr Alebachew Fasil Ashagre
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