Associate Professor Lyndsey Collins-Praino
Associate Prof/Reader
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD, but is currently at capacity - email supervisor to discuss availability.
Dr Lyndsey Collins-Praino holds a PhD in behavioral neuroscience. Her research focuses on the pathophysiological mechanisms underlying cognitive decline in healthy aging and in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. She is particularly interested in the role of inflammation in this process. Her research has appeared in a variety of high-quality, peer-reviewed journals, and she has presented it at both national and international conferences. Lyndsey is the recipient of numerous prestigious fellowships, honours and awards for the novelty, quality and interest of this work, including a 2016 South Australian Young Tall Poppy award. Her research can be seen featured in multiple media outlets..
In addition to her research background, Lyndsey has significant teaching experience. She is co-convenor of the Neuroscience major in the Bachelor of Health and Medical Sciences, and teaches neuroanatomy and neuroscience courses to nursing, medical and health sciences students. Her commitment to teaching has been recognized by her receipt of the Executive Dean's Award for Teaching Excellence (2015) and the STEM Educator of the Year Award at the 2016 SA Science Excellence Awards.
Lyndsey is also heavily involved in neuroscience outreach in the local community. She has a strong commitment to making neuroscience content accessible and fun to children and young adults in the community, particularly to members of groups who are traditionally under-represented in the field. Lyndsey is the founder and organiser of the Kids Navigate Neuroscience event, held annually during National Science Week, and generously supported by a National Science Week grant. She is Treasurer of the National Science Week Committee (SA) and a member of the Inspiring South Australia Steering Group. She is also involved in raising community awareness of Parkinson's Disease, and volunteers as a speaker for Parkinson's SA.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
I am the Head of the Cognition, Ageing and Neurodegenerative Disease laboratory (CANDL). Within CANDL, our research utilises an innovative "dish to deathbed" approach to identify novel predictors of the risk/rate of cognitive decline both in healthy ageing and in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. We are particularly interested on the role of neuroinflammation in this process.
Currently, there are a number of projects ongoing. Some of these include
1. Investigation of whether targeting aberrant neuroinflammation can improve functional outcomes and slow dopamine neuron degeneration in pre-clinical models of Parkinson's disease.
2. Identification of novel methods to prevent the spread of pathological proteins in neurodegenerative disease.
3. Investigation of whether growth factor administration is able to prevent neurodegeneration and reduce chronic inflammation following traumatic brain injury.
4. Use of novel genomic analyses and cognitive data to predict risk and rate of cognitive decline in healthy ageing and Parkinson's disease.
5. Investigation of whether a neuroinflammatory signature is predictive of conversion to dementia in Parkinson's disease.
6. Assessment of the role of microglia in pathological transmission of alpha synuclein.
7. Use of cognitive training to improve cognitive function in Parkinson's disease.
8. Tracking the evolution of parkinsonian like-pathology following traumatic brain injury.
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Appointments
Date Position Institution name 2020 - ongoing Associate Professor University of Adelaide 2017 - 2019 Senior Lecturer, Anatomy and Pathology University of Adelaide 2014 - 2016 Lecturer University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Award Early Career STEM Educator of the Year (Tertiary Teaching) - - - 2016 Award Executive Dean's Award for Teaching Excellence - - - 2016 Fellowship International Neurotrauma Symposium travel fellowship - - - 2016 Award South Australian Young Tall Poppy (Finalist, Tall Poppy of the Year) - - - 2015 Award Unsung euro of South Australian Science, Finalist - - - 2012 Fellowship Society for Neuroscience/Japanese Neuroscience Society Travel Award - - - 2012 Fellowship Alzheimer’s Disease International Conference travel fellowship - - - 2012 Award Henry Taub Award for Best Poster Presentation Columbia University Medical Centre United States - 2012 Fellowship NIA Butler-Williams Scholar - - - 2010 Award Outstanding Scientific Presentation University of Connecticut Health Center United States - 2010 Award Tieman Research Prize NEURON Conference - - 2010 Fellowship Society for Neuroscience Graduate Student Travel Award - - - 2010 Fellowship International Basal Ganglia Society travel fellowship - - - 2006 Award Excellence in Neuroscience University of Scranton United States - -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Italian Can read, write, speak and understand spoken -
Research Interests
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Journals
Year Citation 2024 Amro, Z., Collins-Praino, L. E., & Yool, A. J. (2024). Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors. Bioscience reports, 44(3), 21 pages.
2024 Guglietti, B., Mustafa, S., Corrigan, F., & Collins-Praino, L. E. (2024). Anatomical distribution of Fyn kinase in the human brain in Parkinson's disease. Parkinsonism and Related Disorders, 118, 5 pages.
2024 Bhattacharjee, R., Jolly, L. A., Corbett, M. A., Wee, I. C., Rao, S. R., Gardner, A. E., . . . Gecz, J. (2024). Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment. Nature Communications, 15(1), 1210-1-1210-5.
2024 Rennie, C., Sives, C., Boyton, I., Diaz, D., Gorrie, C., Vittorio, O., . . . Care, A. (2024). In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery. Advanced Therapeutics, 7(2).
2024 Boyton, I., Valenzuela, S. M., Collins-Praino, L. E., & Care, A. (2024). Neuronanomedicine for Alzheimer's and Parkinson's disease: Current progress and a guide to improve clinical translation. Brain, Behavior, and Immunity, 115, 631-651.
Scopus1 Europe PMC12024 Gabbe, B. J., Keeves, J., Mckimmie, A., Gadowski, A. M., Holland, A. J., Semple, B. D., . . . Honeybul, S. (2024). The Australian Traumatic Brain Injury Initiative: Systematic Review and Consensus Process to Determine the Predictive Value of Demographic, Injury Event, and Social Characteristics on Outcomes for People With Moderate-Severe Traumatic Brain Injury. Journal of Neurotrauma.
Scopus12023 Hood, R. J., Sanchez-Bezanilla, S., Beard, D. J., Rust, R., Turner, R. J., Stuckey, S. M., . . . Ong, L. K. (2023). Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke. Journal of Neurochemistry, 167(6), 733-752.
2023 Haller, O. J., Semendric, I., George, R. P., Collins-Praino, L. E., & Whittaker, A. L. (2023). The effectiveness of anti-inflammatory agents in reducing chemotherapy-induced cognitive impairment in preclinical models – a systematic review. Neuroscience & Biobehavioral Reviews, 148, 105120-1-105120-37.
Scopus2 WoS12023 Semendric, I., Pollock, D., Haller, O., George, R., Collins-Praino, L., & Whittaker, A. (2023). "Chemobrain" in childhood cancer survivors - the impact on social, academic, and daily living skills: a qualitative systematic review. Supportive Care in Cancer, 31(9), 532-1-532-15.
Scopus12023 Saywell, I., Child, B., Foreman, L., Collins‐Praino, L., & Baetu, I. (2023). Influence of cognitive reserve on cognitive and motor function in α‐synucleinopathies: A systematic review protocol. Annals of the New York Academy of Sciences, 1522(1), 15-23.
2023 Corrigan, F., Arulsamy, A., Shultz, S. R., Wright, D. K., & Collins-Praino, L. E. (2023). Initial Severity of Injury Has Little Effect on the Temporal Profile of Long-Term Deficits in Locomotion, Anxiety, and Cognitive Function after Diffuse Traumatic Brain Injury. Neurotrauma Reports, 4(1), 41-50.
Scopus12023 Amro, Z., Ryan, M., Collins-Praino, L. E., & Yool, A. J. (2023). Unexpected Classes of Aquaporin Channels Detected by Transcriptomic Analysis in Human Brain Are Associated with Both Patient Age and Alzheimer’s Disease Status. Biomedicines, 11(3), 1-19.
Scopus1 Europe PMC12023 Corrigan, F., Wee, I. C., & Collins-Praino, L. E. (2023). Chronic motor performance following different traumatic brain injury severity—A systematic review. Frontiers in Neurology, 14, 47 pages.
Scopus4 Europe PMC32022 Semendric, I., Pollock, D., Haller, O., George, R., Collins-Praino, L., & Whittaker, A. (2022). ‘‘Chemobrain’’ in childhood cancer survivors - the impact on social, academic, and daily living skills: a qualitative systematic review protocol. JBI Evidence Synthesis, 20(1), 222-228.
Scopus1 WoS1 Europe PMC12022 Guglietti, B., Hobbs, D. A., Wesson, B., Ellul, B., McNamara, A., Drum, S., & Collins-Praino, L. E. (2022). Development and Co-design of NeuroOrb: A Novel "Serious Gaming" System Targeting Cognitive Impairment in Parkinson's Disease.. Frontiers in aging neuroscience, 14, 1-18.
Scopus12021 Kaukas, L., Holmes, J. L., Rahimi, F., Collins-Praino, L., & Corrigan, F. (2021). Injury during adolescence leads to sex-specific executive function deficits in adulthood in a pre-clinical model of mild traumatic brain injury.. Behav Brain Res, 402, 1-14.
Scopus6 WoS5 Europe PMC42021 El-Gamal, M., Salama, M., Collins-Praino, L. E., Baetu, I., Fathalla, A. M., Soliman, A. M., . . . Moustafa, A. A. (2021). Neurotoxin-Induced Rodent Models of Parkinson’s Disease: Benefits and Drawbacks. Neurotoxicity Research, 39(3), 827-923.
Scopus18 WoS14 Europe PMC102021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.. Mol Brain, 14(1), 83.
Scopus7 WoS6 Europe PMC42021 Guglietti, B., Carr, L., Ellul, B., Mustafa, S., Corrigan, F., & Collins-Praino, L. E. (2021). Fyn kinase inhibition using AZD0530 improves recognition memory and reduces depressive-like behaviour in an experimental model of Parkinson’s disease.
2021 Guglietti, B., Sivasankar, S., Mustafa, S., Corrigan, F., & Collins-Praino, L. E. (2021). Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target?. Mol Neurobiol, 58(11), 5986-6005.
Scopus21 WoS14 Europe PMC142021 Amro, Z., Yool, A. J., & Collins-Praino, L. E. (2021). The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathies. Brain, behavior, & immunity - health, 14, 100242-1-100242-14.
Scopus14 WoS11 Europe PMC102021 Guglietti, B., Hobbs, D., & Collins-Praino, L. E. (2021). Optimizing Cognitive Training for the Treatment of Cognitive Dysfunction in Parkinson's Disease: Current Limitations and Future Directions.. Front Aging Neurosci, 13, 709484.
Scopus6 WoS4 Europe PMC52021 Stuckey, S. M., Ong, L. K., Collins-Praino, L. E., & Turner, R. J. (2021). Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?. International Journal of Molecular Sciences, 22(23), 1-45.
Scopus47 WoS30 Europe PMC302021 Boyton, I., Goodchild, S. C., Diaz, D., Elbourne, A., Collins-Praino, L. E., & Care, A. (2021). Characterizing the Dynamic Disassembly/Reassembly Mechanisms of Encapsulin Protein Nanocages. ACS OMEGA, 7(1), 823-836.
Scopus10 WoS5 Europe PMC22021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Differential effects of loss of <i>park7</i> activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s disease.
2021 Sanchez-Bezanilla, S., Hood, R. J., Collins-Praino, L. E., Turner, R. J., Walker, F. R., Nilsson, M., & Ong, L. K. (2021). More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke. Journal of Cerebral Blood Flow and Metabolism, 14(9), 2439-2455.
Scopus15 WoS13 Europe PMC112021 Kaukas, L., Krieg, J., Collins-Praino, L., & Corrigan, F. (2021). Effects of Remote Immune Activation on Performance in the 5-Choice Serial Reaction Time Task Following Mild Traumatic Brain Injury in Adolescence. Frontiers in Behavioral Neuroscience, 15, 1-10.
Scopus2 WoS2 Europe PMC22020 Gutteridge, D. S., Saredakis, D., Badcock, N. A., Collins-Praino, L. E., & Keage, H. A. D. (2020). Cerebrovascular function during cognition in Parkinson's disease: a functional transcranial Doppler sonography study. Journal of the Neurological Sciences, 408, 1-8.
Scopus7 WoS6 Europe PMC72020 Sun, M., McDonald, S. J., Brady, R. D., Collins-Praino, L., Yamakawa, G. R., Monif, M., . . . Shultz, S. R. (2020). The need to incorporate aged animals into the preclinical modeling of neurological conditions. Neuroscience and Biobehavioral Reviews, 109, 114-128.
Scopus32 WoS25 Europe PMC132020 Mohamed, A. Z., Corrigan, F., Collins-Praino, L. E., Plummer, S. L., Soni, N., & Nasrallah, F. A. (2020). Evaluating spatiotemporal microstructural alterations following diffuse traumatic brain injury. NeuroImage: Clinical, 25, 15 pages.
Scopus26 WoS18 Europe PMC172020 Sheynin, J., Baetu, I., Collins-Praino, L. E., Myers, C. E., Winwood-Smith, R., & Moustafa, A. A. (2020). Maladaptive avoidance patterns in Parkinson's disease are exacerbated by symptoms of depression. Behavioural Brain Research, 382, 112473-1-112473-9.
Scopus22020 Pardo, M., Paul, N. E., Collins-Praino, L. E., Salamone, J. D., & Correa, M. (2020). The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making. Pharmacology Biochemistry and Behavior, 198, 1-11.
Scopus7 Europe PMC52020 Iacopetta, K., Collins-Praino, L. E., Buisman-Pijlman, F., Liu, J., Hutchinson, A., & Hutchinson, M. R. (2020). Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review. Nutritional Neuroscience, 23(4), 251-280.
Scopus13 WoS11 Europe PMC52019 Collins-Praino, L. E., & Byard, R. W. (2019). Infants who die in shared sleeping situations differ from those who die while sleeping alone. Acta Paediatrica, International Journal of Paediatrics, 108(4), 611-614.
Scopus11 WoS10 Europe PMC42019 Arulsamy, A., Corrigan, F., & Collins-Praino, L. E. (2019). Cognitive and neuropsychiatric impairments vary as a function of injury severity at 12 months post-experimental diffuse traumatic brain injury: implications for dementia development. Behavioural Brain Research, 365, 66-76.
Scopus13 WoS10 Europe PMC62019 Arulsamy, A., Corrigan, F., & Collins-Praino, L. E. (2019). Age, but not severity of injury, mediates decline in executive function: validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury. Behavioural Brain Research, 368, 1-14.
Scopus3 WoS2 Europe PMC32019 Saredakis, D., Collins-Praino, L. E., Gutteridge, D. S., Stephan, B. C. M., & Keage, H. A. D. (2019). Conversion to MCI and dementia in Parkinson's disease: a systematic review and meta-analysis. Parkinsonism and Related Disorders, 65, 20-31.
Scopus72 WoS63 Europe PMC342018 Collins-Praino, L. E., Gutschmidt, D., Sharkey, J., Arulsamy, A., & Corrigan, F. (2018). Temporal changes in tau phosphorylation and related kinase and phosphatases following two models of traumatic brain injury. Journal of Neuroinflammation and Neurodegenerative Disease, 2(1), 10007-1-10007-13. 2018 Collins-Praino, L., & Corrigan, F. (2018). Cerebrovascular contribution to dementia development after traumatic brain injury: promises and problems. Annals of translational medicine, 6(Suppl. 1), S58-1-S58-5.
WoS12018 Iacopetta, K., Collins-Praino, L., Buisman-Pijlman, F., & Hutchinson, M. (2018). Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?. Brain, Behavior, and Immunity, 73, 125-132.
Scopus2 WoS1 Europe PMC32018 Collins-Praino, L., Arulsamy, A., Katharesan, V., & Corrigan, F. (2018). The effect of an acute systemic inflammatory insult on the chronic effects of a single mild traumatic brain injury. Behavioural Brain Research, 336, 22-31.
Scopus35 WoS34 Europe PMC202018 Spinelli, J., Byard, R. W., Van Den Heuvel, C., & Collins-Praino, L. E. (2018). Medullary Astrogliosis in Sudden Infant Death Syndrome Varies With Sleeping Environment: Evidence for Different Mechanisms of Death in Alone Versus Co-sleepers?. Journal of child neurology, 33(4), 269-274.
Scopus11 WoS8 Europe PMC22018 Arulsamy, A., Teng, J., Colton, H., Corrigan, F., & Collins-Praino, L. (2018). Evaluation of early chronic functional outcomes and their relationship to pre-frontal cortex and hippocampal pathology following moderate-severe traumatic brain injury. Behavioural Brain Research, 348, 127-138.
Scopus19 WoS18 Europe PMC72017 Spinelli, J., Collins-Praino, L., Van Den Heuvel, C., & Byard, R. (2017). Evolution and significance of the triple risk model in sudden infant death syndrome. Journal of Paediatrics and Child Health, 53(2), 112-115.
Scopus22 WoS17 Europe PMC112017 Corrigan, F., Arulsamy, A., Collins-Praino, L., Holmes, J., & Vink, R. (2017). Toll like receptor 4 activation can be either detrimental or beneficial following mild repetitive traumatic brain injury depending on timing of activation. Brain, Behavior, and Immunity, 64(3), 124-139.
Scopus35 WoS32 Europe PMC172017 Corrigan, F., Arulsamy, A., Teng, J., & Collins-Praino, L. (2017). Pumping the Brakes: Neurotrophic Factors for the Prevention of Cognitive Impairment and Dementia after Traumatic Brain Injury. Journal of Neurotrauma, 34(5), 971-986.
Scopus16 WoS13 Europe PMC62017 Collins-Praino, L., & Corrigan, F. (2017). Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?. Brain, Behavior, and Immunity, 60, 369-382.
Scopus64 WoS57 Europe PMC402014 Collins-Praino, L. E., Francis, Y. I., Griffith, E. Y., Wiegman, A. F., Urbach, J., Lawton, A., . . . Brickman, A. M. (2014). Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity.. Acta neuropathologica communications, 2(1), 1-10.
Europe PMC392014 Brickman, A., Schupf, N., Manly, J., Stern, Y., Luchsinger, J., Provenzano, F., . . . Portet, F. (2014). APOE ε4 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role?. Alzheimer's and Dementia, 10(6), 619-629.
Scopus51 WoS47 Europe PMC452014 Collins-Praino, L., Francis, Y., Griffith, E., Wiegman, A., Urbach, J., Lawton, A., . . . Brickman, A. (2014). Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity. Acta Neuropathologica Communications, 2(1), 83-1-83-10.
Scopus51 WoS532013 Salamone, J., Collins-Praino, L., Pardo, M., Podurgiel, S., Baqi, Y., Muller, C., . . . Correa, M. (2013). Conditional neural knockout of the adenosine A₂A receptor and pharmacological A₂A antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor. European Neuropsychopharmacology, 23(8), 972-977.
Scopus25 WoS20 Europe PMC112013 Podurgiel, S., Collins-Praino, L., Yohn, S., Randall, P., Roach, A., Lobianco, C., & Salamone, J. (2013). Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. Pharmacology Biochemistry and Behavior, 105, 105-111.
Scopus28 WoS27 Europe PMC152013 Collins-Praino, L., Paul, N., Ledgard, F., Podurgiel, S., Kovner, R., Baqi, Y., . . . Salamone, J. (2013). Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism. European Journal of Neuroscience, 38(1), 2183-2191.
Scopus18 WoS16 Europe PMC82012 Santerre, J., Nunes, E., Kovner, R., Leser, C., Randall, P., Collins-Praino, L., . . . Salamone, J. (2012). The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions. Pharmacology, Biochemistry and Behavior, 102(4), 477-487.
Scopus41 WoS37 Europe PMC222012 Collins-Praino, L., Podurgiel, S., Kovner, R., Randall, P., & Salamone, J. (2012). Extracellular GABA in globus pallidus increases during the induction of oral tremor by haloperidol but not by muscarinic receptor stimulation. Behavioural Brain Research, 234(1), 129-135.
Scopus13 WoS12 Europe PMC82012 Collins-Praino, L., Sager, T., Sams, A., Pennarola, A., Port, R., Shahriari, M., & Salamone, J. (2012). The novel adenosine A₂A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacology Biochemistry and Behavior, 100(3), 498-505.
Scopus36 WoS28 Europe PMC182011 Collins-Praino, L., Paul, N., Rychalsky, K., Hinman, J., Chrobak, J., Senatus, P., & Salamone, J. (2011). Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor. Frontiers in Systems Neuroscience, 5(JULY 2011), 49:1-49:14.
Scopus31 WoS27 Europe PMC182011 Collins-Praino, L., Paul, N., Abbas, S., Leser, C., Podurgiel, S., Galtieri, D., . . . Salamone, J. (2011). Oral tremor induced by galantamine in rats: a model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease. Pharmacology Biochemistry and Behavior, 99(3), 414-422.
Scopus28 WoS26 Europe PMC172010 Sink, K., Segovia, K., Sink, J., Randall, P., Collins-Praino, L., Correa, M., . . . Salamone, J. (2010). Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142. European Neuropsychopharmacology, 20(2), 112-122.
Scopus68 WoS62 Europe PMC512010 Collins-Praino, L., Galtieri, D., Brennum, L., Sager, T., Hockemeyer, J., Muller, C., . . . Salamone, J. (2010). Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. Pharmacology Biochemistry and Behavior, 94(4), 561-569.
Scopus37 WoS33 Europe PMC202010 Collins-Praino, L., Galtieri, D., Collins, P., Jones, S., Port, R., Paul, N., . . . Salamone, J. (2010). Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: effects on locomotor activity. Behavioural Brain Research, 211(25), 148-155.
Scopus46 WoS42 Europe PMC292010 Farrar, A., Segovia, K., Randall, P., Nunes, E., Collins-Praino, L., Stopper, C., . . . Salamone, J. (2010). Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors. Neuroscience, 166(4), 1056-1067.
Scopus91 WoS87 Europe PMC612010 Sink, K., Segovia, K., Collins-Praino, L., Markus, E., Vemuri, V., Makriyannis, A., & Salamone, J. (2010). The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats. Pharmacology Biochemistry and Behavior, 95(4), 479-484.
Scopus39 WoS35 Europe PMC202010 Salamone, J., Correa, M., Farrar, A., Nunes, E., & Collins-Praino, L. (2010). Role of dopamine-adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation. Future Neurology, 5(3), 377-392.
Scopus32 WoS322009 Mott, A., Nunes, E., Collins-Praino, L., Port, R., Sink, K., Hockemeyer, J., . . . Salamone, J. (2009). The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure. Psychopharmacology, 204(1), 103-112.
Scopus93 WoS83 Europe PMC642009 Salamone, J., Farrar, A., Font, L., Patel, V., Schlar, D., Nunes, E., . . . Sager, T. (2009). Differential actions of adenosine A₁ and A₂A antagonists on the effort-related effects of dopamine D₂ antagonism. Behavioural Brain Research, 201(1), 216-222.
Scopus82 WoS75 Europe PMC512009 Sink, K., Segovia, K., Nunes, E., Collins-Praino, L., Vemuri, V., Thakur, G., . . . Salamone, J. (2009). Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology, 206(2), 223-232.
Scopus21 WoS20 Europe PMC162006 Collins, L. E., & Waldeck, R. F. (2006). Telencephalic ablation results in decreased startle response in goldfish. Brain Research, 1111(1), 162-165.
Scopus3 WoS3- Wee, I. C., Arulsamy, A., Corrigan, F., & Collins-Praino, L. (n.d.). Long-Term Impact of Diffuse Traumatic Brain Injury on Neuroinflammation and Catecholaminergic Signaling: Potential Relevance for Parkinson’s Disease Risk. Molecules, 29(7), 1470.
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Book Chapters
Year Citation 2022 Collins-Praino, L. E. (2022). Traumatic axonal injury as a key driver of the relationship between traumatic brain injury, cognitive dysfunction, and dementia. In R. Rajendram,, V. R. Preedy, & C. R. Martin (Eds.), Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury (pp. 475-486). United Kingdom: Academic Press.
Scopus12020 Foreman, L. M., Baetu, I., Rego, J., Collins-Praino, L., & Moustafa, A. (2020). Theories of compulsive drug use: A brief overview of learning and motivation processes. In A. Moustafa (Ed.), Cognitive, Clinical, and Neural Aspects of Drug Addiction (pp. 137-185). London, United Kingdom: Academic Press.
2014 Salamone, J., Podurgiel, S., Collins-Praino, L., & Correa, M. (2014). Physiological and behavioral assessment of tremor in rodents. In M. LeDoux (Ed.), Movement Disorders: Genetics and Models (2 ed., pp. 631-640). Elsevier.
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Conference Papers
Year Citation 2023 McNamara, A., Ellul, B., Baetu, I. -I., Lau, S., Jenkinson, M., & Collins-Praino, L. (2023). Utility of Baseline Pathological, Neuroimaging and Clinical Markers for Progression Prognosis and Subtype Classification in Early Parkinson's Disease: Implications for Cognitive Impairment. In Accepted for publication in Alzheimer's & Dementia Journal in June 2024 (pp. 2 pages). Amsterdam, The Netherlands: Alzheimer's Association. 2017 Collins-Praino, L., Burton, J., & Johnson, I. (2017). Integration of a novel three-dimensional teaching tool for undergraduate neuroanatomy: student opinions and learning outcomes.. In Journal of Anatomy Vol. 230 (pp. 358). Sussex, UK: Blackwell Publishing Inc.. -
Conference Items
Year Citation 2023 McNamara, A., Ellul, B., Baetu, I. -I., Lau, S., Jenkinson, M., & Collins-Praino, L. (2023). Predicting progression of Parkinson’s disease motor outcomes using a multimodal combination of baseline clinical measures, neuroimaging and biofluid markers. Poster session presented at the meeting of Abstracts of the 6th World Parkinson Congress, as published in Journal of Parkinson's Disease. Barcelona, Spain: IOS Press.
2023 Ellul, B., McNamara, A., Baetu, I., Lau, S., Jenkinson, M., & Collins-Praino, L. (2023). Predicting longitudinal cognition and mood changes in newly diagnosed Parkinson's Disease from substantia nigra imaging (Oral Presentation). Poster session presented at the meeting of ACNS Conference Sydney 2023. https://drive.google.com/drive/folders/1Ixovo4O6LZNfSrf4S0Ds6vkbmyayHHEt. 2022 McNamara, A., Ellul, B., Baetu, I., Lau, S., Jenkinson, M., & Collins-Praino, L. (2022). Predicting Progression of Parkinson’s Disease Motor Outcomes Using a Multimodal Combination of Baseline Clinical Measures, Neuroimaging and Biofluid Markers in Early PD. Poster session presented at the meeting of Australasian Neuroscience Conference 2022. Melbourne. 2022 Ellul, B., McNamara, A., Baetu, I., Lau, S., Jenkinson, M., & Collins-Praino, L. (2022). The role of the substantia nigra in predicting longitudinal cognitive and mood changes in newly diagnosed Parkinson’s Disease. Poster session presented at the meeting of Australasian Neuroscience Conferences 2022. Melbourne, Australia. 2019 Child, B. D., Baetu, I., Collins-Praino, L., & Burns, N. (2019). Reinforcement learning in Parkinson’s disease: Do motor symptoms predict performance?. Poster session presented at the meeting of 28th Annual Meeting of the International Behavioral Neuroscience Society. Cairns, Australia. 2019 Corrigan, F., Kaukas, L., Collins-Praino, L., & Holmes, J. (2019). EFFECT OF A MILD TRAUMATIC BRAIN INJURY DURING ADOLESCENCE ON EXECUTIVE FUNCTION IN ADULTHOOD. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Pittsburgh, PA: MARY ANN LIEBERT, INC. 2019 Child, B. D., Baetu, I., Collins-Praino, L., Salamon, J., & Burns, N. (2019). Reinforcement learning in Parkinson's disease: Do motor symptoms predict performance?. Poster session presented at the meeting of Florey Postgraduate Research Conference. Adelaide, Australia. 2018 Johnson, I., Collins-Praino, L., & Burton, J. (2018). They liked it, but did they learn anything?. Poster session presented at the meeting of Clinical Anatomy. Canberra, Australia: Wiley. 2016 Collins-Praino, L., Teng, J., Colton, H., Van den Heuvel, C., & Corrigan, F. (2016). INVESTIGATING THE COMPLEX RELATIONSHIP BETWEEN NEUROINFLAMMATION, NEURODEGENERATION AND LONG-TERM FUNCTIONAL OUTCOMES IN AN EXPERIMENTAL MODEL OF TRAUMATIC BRAIN INJURY. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Cape Town, SOUTH AFRICA: MARY ANN LIEBERT, INC. 2016 Corrigan, F., & Vink, R. (2016). Toll like receptor 4 activation can be either detrimental or beneficial following mild repetitive traumatic brain injury depending on timing of activation. Poster session presented at the meeting of Abstracts of the 12th Symposium of the International Neurotrauma Society, as published in Journal of Neurotrauma. Cape Town, SOUTH AFRICA: Mary Ann Liebert.
2015 Collins-Praino, L., Burton, J., & Johnson, I. P. (2015). Evaluation of the utility of an in-house three-dimensional teaching tool for undergraduate neuroanatomy. Poster session presented at the meeting of Abstracts presented at the Australian and New Zealand Association of Clinical Anatomists (ANZACA) 11th annual meeting, “Anatomy in work and play,” 3rd to 5th December 2014, Queenstown, Otago, New Zealand, as published in Clinical Anatomy. Queenstown, New Zealand: Wiley.
2012 Collins‐Praino, L., Scarmeas, N., Manly, J., Schupf, N., Noble, J., Provenzano, F., . . . Brickman, A. (2012). P3‐193: White matter hyperintensities may mediate the relationship between inflammation and cognition in an elderly cohort. Poster session presented at the meeting of Alzheimer's & Dementia. Wiley.
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Internet Publications
Year Citation 2021 Haller, O., Whittaker, A., George, R., Semendric, I., & Collins-Praino, L. (2021). Investigating the effects of anti-inflammatory agents in pre-clinical models of chemotherapy-induced cognitive impairment – a systematic review protocol. PROSPERO- registration no: CRD42021240789. 2021 Semendric, I., Haller, O., George, R., Pollock, D., Whittaker, A., & Collins-Praino, L. (2021). Experience of the impact of chemobrain in childhood cancer survivors: a qualitative systematic review protocol. PROSPERO 2021 CRD42021240573. PROSPERO. -
Preprint
Year Citation 2024 Haller, O. J., Semendric, I., Collins-Praino, L. E., Whittaker, A. L., & George, R. P. (2024). Changes in cognition and neuroinflammation in a rodent model of chemotherapy-induced cognitive impairment are variable both acutely and chronically.
Since 2014, I have received over $1.5 million in competitive research funding. Funding bodies include the Australian Research Council (ARC), Neurosurgical Research Foundation, James and Diana Ramsay Foundation, Brain Foundation, the Australia-Japan Foundation, Perpetual IMPACT Philanthropy Application Program and Adelaide Research and Innovation.
Prior to coming to the University of Adelaide, I taught neuroscience, psychology and anatomy courses at the University of Connecticut (Storrs, CT, USA), Fairfield University (Fairfield, CT, USA) and Eastern Connecticut State University (Willimantic, CT, USA).
At the University of Adelaide, I currently teach into a number of courses in the Bachelors of Health and Medical Sciences, including:
- Foundations of Human Neuroanatomy (Coordinator)
- Essentials of Neuroscience (Co-Coordinator)
- Neurological Diseases
- Essential Understanding of Disease and Treatment
- Ethics, Science and Society
- Exercise, Movement and Cognition
In addition to my teaching duties in the Bachelor of Health and Medical Sciences program, I provide a large portion of neuroanatomy content across Years 1-3 of the MBBS program.
I am Co-Convenor of the Neuroscience major in the Bachelor of Health and Medical Science program.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Principal Supervisor Characterising cognitive impairment within individuals diagnosed with Parkinson's Disease, Cancer, and Spinal Cord Injury, and developing novel strategies to target this. Doctor of Philosophy Doctorate Full Time Ms Madeleine Anne Homes-Vickers 2022 Co-Supervisor Development of a New Cognitive Reserve Measure: Implications for Parkinson’s Disease and Traumatic Brain Injury Doctor of Philosophy Doctorate Full Time Mr Isaac Calvin Saywell 2022 Principal Supervisor Assessing olfactory system pathology and accelerated a-synuclein spread following
Traumatic Brain Injury, and their role in the development of Parkinson's Disease pathology.Doctor of Philosophy Doctorate Full Time Ms Samantha Elizabeth Edwards 2022 Co-Supervisor Characterising the role of cognitive dysfunction and spread of underlying tau pathology in the development of Alzheimer's disease following traumatic brain injury Doctor of Philosophy Doctorate Full Time Miss Eleanor Rose Bowley-Schubert 2021 Co-Supervisor Understanding the mechanisms of chemotherapy-induced cognitive impairment with a focus on neuroinflammation Doctor of Philosophy Doctorate Full Time Miss Olivia Jane Haller 2021 Principal Supervisor The Role of the Substantia Nigra in predicting longitudinal non-motor changes in Parkinson's Disease Doctor of Philosophy Doctorate Full Time Mr Benjamin Paul Ellul 2021 Principal Supervisor Chemobrain impact and remediation: a focus on the paediatric patient Doctor of Philosophy Doctorate Full Time Miss Ines Semendric 2021 Co-Supervisor COVID-19 related cognitive impairment: Underlying mechanisms and protective factors Doctor of Philosophy Doctorate Part Time Ms Lauren Mary Heidenreich 2021 Principal Supervisor “Utility of Inflammatory Biomarkers to Predict Brainstem Imaging Changes in Parkinson’s Disease and TBI” Doctor of Philosophy Doctorate Full Time Mr Angus McNamara 2021 Principal Supervisor Nanoparticle based strategies for the treatment of Parkinson's Disease: opportunities and challenges Doctor of Philosophy Doctorate Full Time Miss Laura May Carr 2020 Co-Supervisor The Role of Neuroinflammation in Delayed Neurodegeneration following Ischemic Stroke Doctor of Philosophy Doctorate Full Time Miss Shannon Mikayla Stuckey 2020 Co-Supervisor The role of neuroinflammation in mediating cognitive deficits following traumatic spinal cord injury: Can Fyn kinase inhibition break the link? Doctor of Philosophy Doctorate Part Time Miss Kavi Sivasankar 2019 Co-Supervisor Blood-Brain Barrier Changes in Healthy Ageing and Disease Doctor of Philosophy Doctorate Part Time Miss Isabella Megan Bilecki 2019 Co-Supervisor An Exploration of the Role of Working Memory in Associative Learning Doctor of Philosophy Doctorate Part Time Miss Brittany Dorothy Amelia Child -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 - 2023 Co-Supervisor Discovery of novel aquaporin subtypes in the human brain: Potential relevance of peroxiporins AQP0 and AQP11 to cellular stress and Alzheimer’s Disease Doctor of Philosophy Doctorate Full Time Mr Zein Alabedyn Amro 2020 - 2024 Principal Supervisor Investigating the impact of individual differences and stress on decision-making performance under threat Master of Philosophy (Medical Science) Master Part Time Mr Manuel Salazar 2019 - 2024 Principal Supervisor Exploring the Behavioural and Brain Basis of the Link Between Traumatic Brain Injury and Parkinson’s disease Doctor of Philosophy Doctorate Full Time Miss Ing Chee Wee 2019 - 2019 Co-Supervisor Peripheral-to-Central Neuroimmune Communication and the Sun: Implications for Addiction and Neurodegenerative Disease Pathology Master of Philosophy (Medical Science) Master Full Time Ms Krystal Lee Iacopetta 2017 - 2021 Principal Supervisor Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non-Pharmacological Approaches Doctor of Philosophy Doctorate Full Time Miss Bianca Laura Guglietti 2015 - 2019 Principal Supervisor From Trauma to Neurodegeneration: A One-Year Time Progression of Functional Impairments and its Associated Neuropathological Link Following Varied Severity of Experimental Diffuse Traumatic Brain Injury Doctor of Philosophy Doctorate Full Time Miss Alina Arulsamy
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Committee Memberships
Date Role Committee Institution Country 2016 - ongoing Member School of Medicine (SOM) Early/Middle Career Researcher Committee University of Adelaide - 2016 - ongoing Treasurer National Science Week Committee (South Australia) - - 2016 - ongoing Member Inspiring South Australia Steering Group - - 2015 - ongoing Chair Year 1 MBBS Committee University of Adelaide - 2015 - ongoing Member MBBS Assessment Committee University of Adelaide - 2015 - ongoing Member Low-Risk Human Research Ethics Committee University of Adelaide - 2015 - ongoing Member MBBS Curriculum Committee Member - - 2015 - 2015 Member School of Medical Sciences Learning and Teaching Committee Member University of Adelaide - 2015 - 2015 Member School of Medical Sciences Seminar Committee University of Adelaide - -
Memberships
Date Role Membership Country 2016 - ongoing - Australasian Cognitive Neuroscience Society - 2016 - ongoing - International Neurotrauma Society - 2015 - ongoing - International Society for Neurochemistry - 2015 - ongoing - Australasian Neuroscience Society - 2006 - ongoing Member Society for Neuroscience - 2006 - ongoing Member International Basal Ganglia Society - -
Offices Held
Date Office Name Institution Country 2016 - ongoing Co-convenor, Neuroscience Major University of Adelaide - 2015 - ongoing Year 1 Convenor, MBBS Program University of Adelaide -
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