Luke Selth

Dr Luke Selth

Senior Research Fellow - DRMCRL

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr Luke Selth
Lab Head and Senior Research Fellow - Dame Roma Mitchell Cancer Research Laboratories and Freemasons Foundation Centre for Men's Health.

Dr Selth heads the Prostate Cancer Research program within the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL), Adelaide Medical School, and holds a key leadership position in the University's Freemasons Foundation Centre for Men’s Health (FFCMH). His research focuses on two aspects of prostate cancer development and progression. The first is aimed at investigating the mechanisms underlying continued androgen signalling in lethal forms of prostate cancer. The second involves research into the role of microRNAs in prostate carcinogenesis and metastasis and their use as potential biomarkers of disease. These research programs utilise contemporary "omic" techniques to better understand prostate cancer at the molecular level.

Dr Selth is a past Young Investigator of Prostate Cancer Foundation of Australia and the Prostate Cancer Foundation (USA). His research is currently funded by competitive grants from various bodies, including the National Health and Medical Research Program, Movember, the National Breast Cancer Foundation and Cancer Australia.

A range of PhD and Honours projects are available in Dr Selth's lab for motivated students - please contact him directly if you are interested.

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  • Appointments

    Date Position Institution name
    2015 Senior Research Fellow University of Adelaide
    2009 - 2014 Research Fellow University of Adelaide
    2005 - 2009 Post-doctoral Fellow Cancer Research UK London Research Institute
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2016 Fellowship Endeavour Research Fellowship
    2015 Research Award Australian Society for Medical Research Leading Light Award (finalist)
    2013 Award South Australian Young Tall Poppy Science Award
    2012 Award Prostate Cancer Foundation Young Investigator Award
    2011 Award Millennium Sciences Award (Lorne Genome Conference)
    2011 Award Prostate Cancer Foundation of Australia Young Investigator Award
    2010 Award International Conference Award University of Adelaide Faculty of Health Sciences
    2005 Fellowship European Molecular Biology Organisation (EMBO) Long-Term Fellowship
  • Education

    Date Institution name Country Title
    2005 University of Adelaide Australia PhD
    2000 Flinders University Australia B. Biotechnology (Honours)
  • Research Interests

Current funding

  1. Dual targeting of the androgen receptor for effective and durable control of lethal prostate cancer. 2017-2020. National Health and Medical Research Council.
  2. The clinical significance of sex hormone crosstalk in estrogen receptor positive breast cancer. 2017-2020. National Health and Medical Research Council.
  3. Targeting microRNA-driven mesenchymal to epithelial transition to suppress prostate cancer metastasis. 2015-2017. National Health and Medical Research Council.
  4. Targeting the Aberrant Androgen Receptor in Advanced Treatment Resistant Prostate Cancer. 2013-2017. US Department of Defense.

Past funding​

  1. Mechanism and targeting of castration-resistant prostate cancer.  2013-2015. Cancer Australia. 

  2. Targeting androgen receptor variant signalling in lethal prostate cancer. 2013-2014. The Ray and Shirl Norman Cancer Research Trust.

  3. Androgen receptor splice variants: novel drivers of castration-resistant prostate cancer. 2012-2014. Prostate Cancer Foundation (Young Investigator award program).

  4. microRNAs in prostate cancer: prognostic markers and therapeutic targets. 2011-2013. Prostate Cancer Foundation of Australia Young Investigator Grant. 

Investigative Cell Biology - Lecturing and supervisor for research placements - 2011-current.

Bachelor of Health Sciences (Advanced) HEALTH 3000A & 3000B - Supervisor for research placements - 2017.

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 Co-Supervisor Female Germline Formation During Plant Development Doctor of Philosophy Doctorate Full Time Mr Dayton Christopher Bird
    2017 Principal Supervisor Interactions between Androgen signalling and the lipid microenvironment in prostate cancer Doctor of Philosophy Doctorate Full Time Mr Raj Kumar Shrestha
    2017 Principal Supervisor Development of Microfluidic Technology for Genomic Studies of Circulation Tumor Cells Doctor of Philosophy Doctorate Full Time Mr Mohammadreza Alizadeh Ghodsi
    2016 Principal Supervisor Unraveling the regulatory network underlying Androgen Deprivation Therapy- induced cancer stem cell traits in prostate cancer Doctor of Philosophy Doctorate Full Time Miss Rayzel Candida Fernandes
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2014 - 2014 Principal Supervisor Curcumin Action in Prostate Cancer Cells and Fibroblasts Doctor of Philosophy Doctorate Full Time Miss Lauren Giorgio
    2014 - 2017 Co-Supervisor MicroRNA Mediated Gene Regulation in Cancer Doctor of Philosophy Doctorate Full Time Ms Qingqing Wang
    2013 - 2016 Co-Supervisor Elucidating the Molecular Action of Synthetic Heat Shock Protein 90 Inhibitors in Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Heather Krista Armstrong
    2013 - 2016 Principal Supervisor The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Rajdeep Das
    2011 - 2015 Co-Supervisor Combinatorial Targeting of the Androgen Receptor for Prostate Cancer Therapy Doctor of Philosophy Doctorate Full Time Miss Sarah Carter
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  • Committee Memberships

    Date Role Committee Institution Country
    2016 - ongoing Member Adelaide Health and Medical School Research Reference Group
    2015 - ongoing Member Faculty of Health Sciences Early/Mid Career Researcher Working Group University of Adelaide
    2014 - ongoing Member University of Adelaide Institutional Biosafety Committee University of Adelaide
  • Editorial Boards

    Date Role Editorial Board Name Institution Country
    2017 - ongoing Board Member Endocrine-Related Cancer
    2015 - ongoing Editor Scientific Reports (Nature Publishing Group)
  • Position: Senior Research Fellow - DRMCRL
  • Phone: 83137860
  • Email: luke.selth@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 8
  • Room: WS8058.02
  • Org Unit: Medical Specialties

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