Dr Luke Selth

Senior Research Fellow - DRMCRL

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Associate Professor Luke Selth

Luke Selth is an Associate Professor at Flinders University and has an Adjunct Associate Professor position associated with the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL), Adelaide Medical School. He is a Cancer Council SA Beat Cancer Principal Cancer Research Fellow in the Flinders Health and Medical Research Institute (FHMRI), where he leads the Prostate Cancer Research Group. He is also member of the Freemasons Centre for Male Health and Wellbeing (FCMHW) and sits on the Scientific Advisory Committee for the South Australian Genomics Centre.

Research in the Selth lab focuses on two aspects of prostate cancer development and progression. The first is aimed at investigating the mechanisms underlying continued androgen signalling in lethal forms of prostate cancer. The second involves research into the role of microRNAs in prostate carcinogenesis and metastasis and their use as potential biomarkers of disease. These research programs utilise contemporary "omic" techniques to better understand prostate cancer at the molecular level.

Selth is a past Young Investigator of Prostate Cancer Foundation of Australia and the Prostate Cancer Foundation (USA). His research is currently funded by competitive grants from various bodies, including Cancer Council SA, Cancer Australia, Movember and The Hospital Research Foundation.

A range of PhD and Honours projects are available in Selth's lab for motivated students - please contact him directly at luke.selth@flinders.edu.au if you are interested.

My Research
Career
Publications
Supervision
Professional Activities
Contact

Appointments

Date	Position	Institution name
2019 - ongoing	Associate Professor	Flinders University
2019 - ongoing	Adjunct Associate Professor	University of Adelaide
2015 - 2019	Senior Research Fellow	University of Adelaide
2009 - 2014	Research Fellow	University of Adelaide
2005 - 2009	Post-doctoral Fellow	Cancer Research UK London Research Institute

Awards and Achievements

Date	Type	Title	Institution Name
2016	Fellowship	Endeavour Research Fellowship
2015	Research Award	Australian Society for Medical Research Leading Light Award (finalist)
2013	Award	South Australian Young Tall Poppy Science Award
2012	Award	Prostate Cancer Foundation Young Investigator Award
2011	Award	Millennium Sciences Award (Lorne Genome Conference)
2011	Award	Prostate Cancer Foundation of Australia Young Investigator Award
2010	Award	International Conference Award	University of Adelaide Faculty of Health Sciences
2005	Fellowship	European Molecular Biology Organisation (EMBO) Long-Term Fellowship

Education

Date Institution name Country Title

2005 University of Adelaide Australia PhD

2000 Flinders University Australia B. Biotechnology (Honours)
Research Interests

Cancer Biology and Clinical Oncology Cancer Cell Biology Cancer Therapy

Date	Institution name	Country	Title
2005	University of Adelaide	Australia	PhD
2000	Flinders University	Australia	B. Biotechnology (Honours)

Journals

Year	Citation
2022	Guo, Z., Yang, C. T., Chien, C. C., Selth, L. A., Bagnaninchi, P. O., & Thierry, B. (2022). Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments. Small Methods, 6(8), e2200471-1-e2200471-13. DOI
2021	Xie, J., Kusnadi, E. P., Furic, L., & Selth, L. A. (2021). Regulation of mRNA translation by hormone receptors in breast and prostate cancer. Cancers, 13(13), 3254-1-3254-26. DOI Scopus6 WoS5 Europe PMC2
2021	Gillis, J. L., Hinneh, J. A., Ryan, N. K., Irani, S., Moldovan, M., Quek, L. -E., . . . Shrestha, R. (2021). A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.. eLife, 10, 27 pages. DOI Scopus6 WoS6 Europe PMC5
2021	Hickey, T. E., Selth, L. A., Chia, K. M., Laven-Law, G., Milioli, H. H., Roden, D., . . . Tilley, W. D. (2021). The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer. Nature Medicine, 27(2), 310-320. DOI Scopus42 WoS43 Europe PMC27
2021	Butler, L. M., Mah, C. Y., Machiels, J., Vincent, A. D., Irani, S., Mutuku, S., . . . Swinnen, J. V. (2021). Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition. Cancer Research, 81(19), 4981-4993. DOI Scopus6 WoS7 Europe PMC7
2021	Che, M., Chaturvedi, A., Munro, S. A., Pitzen, S. P., Ling, A., Zhang, W., . . . Dehm, S. M. (2021). Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer. Nature Communications, 12(1), 6377-1-6377-15. DOI Scopus2 WoS2
2021	Davies, A., Nouruzi, S., Ganguli, D., Namekawa, T., Thaper, D., Linder, S., . . . Zoubeidi, A. (2021). An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer.. Nature cell biology, 23(9), 33 pages. DOI Scopus13 WoS12 Europe PMC6
2021	Choo, N., Ramm, S., Luu, J., Winter, J. M., Selth, L. A., Dwyer, A. R., . . . Simpson, K. J. (2021). High-throughput imaging assay for drug screening of 3D prostate cancer organoids. SLAS Discovery, 26(9), 1107-1124. DOI Scopus3 WoS4 Europe PMC2
2021	John, A., John, H., Catterwell, R., Selth, L. A., & Callaghan, M. O. (2021). Primary Gleason grade and Gleason grade group at positive surgical margins: a systematic review and meta-analysis. BJU International, 127(S1), 13-22. DOI Scopus5 WoS4 Europe PMC4
2021	Xie, J., De Poi, S. P., Humphrey, S. J., Hein, L. K., Bruning, J. B., Pan, W., . . . Proud, C. G. (2021). TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling. Cellular and Molecular Life Sciences, 78(8), 4035-4052. DOI
2021	Centenera, M. M., Scott, J. S., Machiels, J., Nassar, Z. D., Miller, D. C., Zinonos, I., . . . Butler, L. M. (2021). ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer. Cancer Research, 81(7), 1704-1718. DOI Scopus16 WoS17 Europe PMC11
2021	Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., . . . Selth, L. A. (2021). Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer. Cell Reports, 34(1), 1-17. DOI Scopus11 WoS9 Europe PMC7
2020	John, A., O'Callaghan, M., Catterwell, R., & Selth, L. (2020). Does Gleason score of positive surgical margin after radical prostatectomy affect biochemical recurrence and oncological outcomes? Protocol for systematic review. BMJ Open, 10(3), 4 pages. DOI Scopus1 WoS1
2020	Montgomery, M. K., Bayliss, J., Devereux, C., Bezawork-Geleta, A., Roberts, D., Huang, C., . . . Watt, M. J. (2020). SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control. Science Translational Medicine, 12(559), 1-13. DOI Scopus16 WoS15 Europe PMC9
2020	Nassar, Z. D., Mah, C. Y., Dehairs, J., Burvenich, I. J., Irani, S., Centenera, M. M., . . . Butler, L. M. (2020). Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Elife, 9, 1-34. DOI Scopus37 WoS33 Europe PMC23
2020	Davies, A. H., Zoubeidi, A., & Selth, L. A. (2020). The epigenetic and transcriptional landscape of neuroendocrine prostate cancer. Endocrine-Related Cancer, 27(2), R35-R50. DOI Scopus30 WoS27 Europe PMC22
2019	Fernandes, R. C., Hickey, T. E., Tilley, W. D., & Selth, L. A. (2019). Interplay between the androgen receptor signaling axis and microRNAs in prostate cancer. Endocrine-Related Cancer, 26(5), R237-R257. DOI Scopus14 WoS14 Europe PMC9
2019	Warren, A., Massie, C., Watt, K., Luko, K., Orafidiya, F., Selth, L., . . . Asim, M. (2019). A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer. Oncogene, 38(7), 1136-1150. DOI Scopus12 WoS12 Europe PMC8
2019	Holding, A. N., Giorgi, F. M., Donnelly, A., Cullen, A. E., Nagarajan, S., Selth, L. A., & Markowetz, F. (2019). Correction to: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer (Genome Biol (2019) 20:91 DOI: 10.1186/s13059-019-1698-z). Genome Biology, 20(1), 2 pages. DOI WoS1 Europe PMC1
2019	Holding, A. N., Giorgi, F. M., Donnelly, A., Cullen, A. E., Nagarajan, S., Selth, L. A., & Markowetz, F. (2019). VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer. Genome Biology, 20(1), 16 pages. DOI Scopus13 WoS14 Europe PMC9
2019	MacFawn, I., Wilson, H., Selth, L., Leighton, I., Serebriiskii, I., Bleackley, R., . . . Frisch, S. (2019). Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers. Molecular Immunology, 105, 137-149. DOI Scopus15 WoS15 Europe PMC11
2019	Das, R., Feng, F. Y., & Selth, L. A. (2019). Long non-coding RNAs in prostate cancer: biological and clinical implications. Molecular and Cellular Endocrinology, 480, 142-152. DOI Scopus7 WoS7 Europe PMC5
2019	Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N., Rebello, R., . . . Taylor, R. A. (2019). Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Science Translational Medicine, 11(478), 1-12. DOI Scopus113 WoS113 Europe PMC62
2019	Lorent, J., Kusnadi, E. P., van Hoef, V., Rebello, R. J., Leibovitch, M., Ristau, J., . . . Furic, L. (2019). Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression. The EMBO Journal, 38(23), e101323-1-e101323-19. DOI Scopus17 WoS15 Europe PMC11
2018	Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages. DOI Scopus50 WoS47 Europe PMC34
2018	Matin, F., Jeet, V., Moya, L., Selth, L., Chambers, S., Clements, J., & Batra, J. (2018). A plasma biomarker panel of four MicroRNAs for the diagnosis of prostate cancer. Scientific Reports, 8(1), 6653-1-6653-15. DOI Scopus49 WoS50 Europe PMC25
2018	Lawrence, M., Obinata, D., Sandhu, S., Selth, L., Wong, S., Porter, L., . . . Frydenberg, M. (2018). Patient-derived models of abiraterone- and enzalutamide-resistant prostate cancer reveal sensitivity to ribosome-directed therapy. European Urology, 74(5), 562-572. DOI Scopus52 WoS52 Europe PMC33
2018	Centenera, M., Selth, L., Ebrahimie, E., Butler, L., & Tilley, W. (2018). New opportunities for targeting the androgen receptor in prostate cancer. Cold Spring Harbor Perspectives in Medicine, 10(12), 1-19. DOI Scopus19 WoS16 Europe PMC12
2018	Luo, J., Attard, G., Balk, S., Bevan, C., Burnstein, K., Cato, L., . . . Raj, G. (2018). Role of androgen receptor variants in prostate cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting. European Urology, 73(5), 715-723. DOI Scopus79 WoS78 Europe PMC51
2018	Armstrong, H., Gillis, J., Johnson, I., Nassar, Z., Moldovan, M., Levrier, C., . . . Butler, L. (2018). Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion. Scientific reports, 8(1), 2090-1-2090-14. DOI Scopus17 WoS18 Europe PMC11
2018	Holding, A., Giorgi, F., Donnelly, A., Cullen, A., Nagarajan, S., Selth, L., & Markowetz, F. (2018). Network analysis of ChIP-seq data by VULCAN identifies GRHL2 as a key co-regulator of ERa in luminal breast cancer. DOI Europe PMC1
2018	Dhahbi, J. M., Atamna, H., & Selth, L. A. (2018). Data mining of small RNA-Seq suggests an association between prostate cancer and altered abundance of 5' transfer RNA halves in seminal fluid and prostatic tissues. Biomarkers in cancer, 10, 1-8. DOI Europe PMC4
2017	Paltoglou, S., Das, R., Townley, S., Hickey, T., Tarulli, G., Coutinho, I., . . . Selth, L. (2017). Novel androgen receptor coregulator GRHL2 exerts both oncogenic and antimetastatic functions in prostate cancer. Cancer Research, 77(13), 3417-3430. DOI Scopus55 WoS52 Europe PMC42
2017	Miao, L., Yang, L., Li, R., Rodrigues, D., Crespo, M., Hsieh, J., . . . Raj, G. (2017). Disrupting androgen receptor signaling induces Snail-mediated epithelial-mesenchymal plasticity in prostate cancer. Cancer Research, 77(11), 3101-3112. DOI Scopus44 WoS40 Europe PMC30
2017	Ponnusamy, S., Coss, C., Thiyagarajan, T., Watts, K., Hwang, D. -J., He, Y., . . . Narayanan, R. (2017). Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer. Cancer Research, 77(22), 6282-6298. DOI Scopus34 WoS36 Europe PMC21
2017	Leach, D. A., Panagopoulos, V., Nash, C., Bevan, C., Thomson, A. A., Selth, L. A., & Buchanan, G. (2017). Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome. Molecular and Cellular Endocrinology, 439(C), 261-272. DOI Scopus20 WoS19 Europe PMC17
2017	Selth, L., Das, R., Townley, S., Coutinho, I., Hanson, A., Centenera, M., . . . Tilley, W. (2017). A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer. Oncogene, 36(1), 24-34. DOI Scopus76 WoS76 Europe PMC49
2017	Pedraza-Arévalo, S., Hormaechea-Agulla, D., Gómez-Gómez, E., Requena, M., Selth, L., Gahete, M., . . . Luque, R. (2017). Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer. Prostate, 77(15), 1499-1511. DOI Scopus22 WoS21 Europe PMC10
2017	Wang, Q., Selth, L., & Callen, D. (2017). MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4. Oncotarget, 8(18), 29914-29924. DOI Scopus22 WoS24 Europe PMC13
2017	Tse, B., Volpert, M., Ratther, E., Stylianou, N., Nouri, M., McGowan, K., . . . Hollier, B. (2017). Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene, 36(24), 3417-3427. DOI Scopus42 WoS45 Europe PMC23
2017	Das, R., Gregory, P. A., Fernandes, R. C., Denis, I., Wang, Q., Townley, S. L., . . . Selth, L. A. (2017). MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2. Cancer Research, 77(4), 1021-1034. DOI Scopus79 WoS80 Europe PMC49
2016	Coutinho, I., Day, T., Tilley, W., & Selth, L. (2016). Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence. Endocrine-Related Cancer, 23(12), T179-T197. DOI Scopus104 WoS98 Europe PMC71
2016	Armstrong, H., Koay, Y., Irani, S., Das, R., Nassar, Z., The Australian Prostate Cancer BioResource., . . . Butler, L. (2016). A novel class of Hsp90 C-terminal modulators have pre-clinical efficacy in prostate tumor cells without induction of a heat shock response. Prostate, 76(16), 1546-1559. DOI Scopus19 WoS20 Europe PMC12
2016	Carter, S. L., Centenera, M. M., Tilley, W. D., Selth, L. A., & Butler, L. M. (2016). Erratum to: IΚBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor.[BMC Cancer. 2016] 16:141. Doi: 10.1186/s12885-016-2188-2.. BMC Cancer, 16(1), 1 page. DOI Europe PMC1
2016	Carter, S., Centenera, M., Tilley, W., Selth, L., & Butler, L. (2016). IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor. BMC Cancer, 16(1), 141-1-141-13. DOI Scopus10 WoS9 Europe PMC6
2016	Roberts, M. J., Richards, R., Chow, C. W. K., Schirra, H., Buck, M., Selth, L. A., . . . Gardiner, R. A. (2016). PROSTATIC FLUID MRNA AND MICRORNA BIOMARKERS: AN EMERGING PARADIGM FOR NONINVASIVE DIAGNOSIS OF PROSTATE CANCER. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 12, 41.
2016	Hu, D., Selth, L., Tarulli, G., Meech, R., Wijayakumara, D., Chanawong, A., . . . Hickey, T. (2016). Androgen and estrogen receptors in breast cancer coregulate human UDP-glucuronosyltransferases 2B15 and 2B17. Cancer Research, 76(19), 5881-5893. DOI Scopus37 WoS37 Europe PMC24
2016	Asim, M., Massie, C., Orafidiya, F., Pértega-Gomes, N., Warren, A., Esmaeili, M., . . . Neal, D. (2016). Choline kinase alpha as an androgen receptor chaperone and prostate cancer therapeutic target. Journal of the National Cancer Institute, 108(5), djv371-1-djv371-13. DOI Scopus31 WoS30 Europe PMC22
2015	Raj, G., Selth, L., Day, T., & Tilley, W. (2015). Evolution of androgen deprivation therapy. Cancer Forum, 39(3), 189-194.
2015	Hickey, T., Irvine, C., Dvinge, H., Tarulli, G., Hanson, A., Ryan, N., . . . Selth, L. (2015). Expression of androgen receptor splice variants in clinical breast cancers. Oncotarget, 6(42), 44728-44744. DOI Scopus58 WoS55 Europe PMC42
2015	Need, E., Selth, L., Trotta, A., Leach, D., Giorgio, L., O'Loughlin, M., . . . Buchanan, G. (2015). The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype. BMC Cancer, 15(1), 791-1-791-17. DOI Scopus25 WoS23 Europe PMC21
2015	Roberts, M., Richards, R., Gardiner, R., & Selth, L. (2015). Seminal fluid: a useful source of prostate cancer biomarkers?. Biomarkers in Medicine, 9(2), 77-80. DOI Scopus15 WoS15 Europe PMC10
2015	Stegeman, S., Moya, L., Selth, L., Spurdle, A., Clements, J., & Batra, J. (2015). A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer. Endocrine-Related Cancer, 22(2), 265-276. DOI Scopus41 WoS42 Europe PMC37
2015	Chan, S., Selth, L., Li, Y., Nyquist, M., Miao, L., Bradner, J., . . . Dehm, S. (2015). Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Research, 43(12), 5880-5897. DOI Scopus114 WoS113 Europe PMC90
2015	Roberts, M., Chow, C., Schirra, H., Richards, R., Buck, M., Selth, L., . . . Gardiner, R. (2015). Diagnostic performance of expression of PCA3, Hepsin and miR biomarkers inejaculate in combination with serum PSA for the detection of prostate cancer. The Prostate, 75(5), 539-549. DOI Scopus33 WoS33 Europe PMC25
2014	Li, X., Roslan, S., Johnstone, C., Wright, J., Bracken, C., Anderson, M., . . . Khew-Goodall, Y. (2014). MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene, 33(31), 4077-4088. DOI Scopus94 WoS87 Europe PMC73
2014	Hu, D., Hickey, T., Irvine, C., Wijayakumara, D., Lu, L., Tilley, W., . . . MacKenzie, P. (2014). Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues. Hormones and Cancer, 5(2), 61-71. DOI Scopus42 WoS39 Europe PMC33
2014	Selth, L. A., Roberts, M. J., Chow, C. W. K., Marshall, V. R., Doi, S. A. R., Vincent, A. D., . . . Gardiner, R. A. (2014). Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers. Endocrine-Related Cancer, 21(4), L17-L21. DOI Scopus30 WoS27 Europe PMC23
2014	Das, R., Gregory, P., Hollier, B., Tilley, W., & Selth, L. (2014). Epithelial plasticity in prostate cancer: principles and clinical perspectives. Trends in Molecular Medicine, 20(11), 643-651. DOI Scopus18 WoS19 Europe PMC13
2013	Chiam, K., Ryan, N., Ricciardelli, C., Day, T., Buchanan, G., Ochnik, A., . . . Bianco-Miotto, T. (2013). Characterization of the prostate cancer susceptibility gene KLF6 in human and mouse prostate cancers. Prostate, 73(2), 182-193. DOI Scopus14 WoS13 Europe PMC12
2013	Trotta, A., Need, E., Selth, L., Chopra, S., Pinnock, C., Leach, D., . . . Buchanan, G. (2013). Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation. International Journal of Cancer, 133(12), 2812-2823. DOI Scopus17 WoS17 Europe PMC14
2013	Larsson, M., Uvell, H., Sandstrom, J., Ryden, P., Selth, L., & Bjorklund, S. (2013). Functional studies of the yeast Med5, Med15 and Med16 mediator tail subunits. PLoS One, 8(8), e73137-1-e73137-10. DOI Scopus13 WoS13 Europe PMC10
2013	Sapre, N., & Selth, L. (2013). Circulating microRNAs as biomarkers of prostate cancer: the state of play. Prostate Cancer, 2013, 1-10. DOI Europe PMC32
2013	Gillis, J., Selth, L., Centenera, M., Townley, S., Sun, S., Plymate, S., . . . Butler, L. (2013). Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors. Oncotarget, 4(5), 691-704. DOI Scopus42 WoS41 Europe PMC34
2013	Selth, L., Townley, S., Bert, A., Stricker, P., Sutherland, P., Horvath, L., . . . Tilley, W. (2013). Circulating microRNAs predict biochemical recurrence in prostate cancer patients. British Journal of Cancer, 109(3), 641-650. DOI Scopus101 WoS102 Europe PMC77
2012	Selth, L., Townley, S., Gillis, J., Ochnik, A., Murti, K., Macfarlane, R., . . . Butler, L. (2012). Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease. International Journal of Cancer, 131(3), 652-661. DOI Scopus141 WoS136 Europe PMC105
2012	Thompson, V., Day, T., Bianco-Miotto, T., Selth, L., Han, G., Thomas, M., . . . Tilley, W. (2012). A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease. International Journal of Cancer, 131(3), 662-672. DOI Scopus27 WoS26 Europe PMC19
2012	Need, E., Selth, L., Harris, T., Birrell, S., Tilley, W., & Buchanan, G. (2012). Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cells. Molecular Endocrinology, 26(11), 1941-1952. DOI Scopus64 WoS60 Europe PMC50
2012	Moore, N., Buchanan, G., Harris, J., Selth, L., Bianco-Miotto, T., Hanson, A., . . . Tilley, W. (2012). An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity. Endocrine-Related Cancer, 19(4), 599-613. DOI Scopus39 WoS38 Europe PMC27
2012	Selth, L., Tilley, W., & Butler, L. (2012). Circulating microRNAs: macro-utility as markers of prostate cancer?. Endocrine-Related Cancer, 19(4), 99-113. DOI Scopus36 WoS33 Europe PMC26
2012	Trotta, A., Need, E., Butler, L., Selth, L., O'Loughlin, M., Coetzee, G., . . . Buchanan, G. (2012). Subdomain structure of the co-chaperone SGTA and activity of its androgen receptor client. Journal of Molecular Endocrinology, 49(2), 57-68. DOI Scopus18 WoS17 Europe PMC16
2011	Selth, L. A., Randles, J. W., & Ali Rezaian, M. (2011). Erratum: Agrobacterium tumefaciens supports DNA replication of diverse geminivirus types (FEBS Letters (2002) 516 (179-182)). FEBS Letters, 585(24), 4030. DOI
2011	Kumar, R., Selth, L., Schulz, R., Tay, B., Neilsen, P., & Callen, D. (2011). Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells. Journal of Cellular Biochemistry, 112(10), 2742-2747. DOI Scopus16 WoS14 Europe PMC16
2010	Kainov, D., Selth, L., Svejstrup, J., Egly, J., & Poterzsman, A. (2010). Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair, 9(1), 33-39. DOI Scopus10 WoS10 Europe PMC7
2010	Selth, L., Sigurdsson, S., & Svejstrup, J. (2010). Transcript elongation by RNA polymerase II. Annual Review of Biochemistry, 79(1), 271-293. DOI Scopus139 WoS139 Europe PMC121
2009	Greenwood, C., Selth, L., Dirac-Svejstrup, A., & Svejstrup, J. (2009). An Iron-Sulfur Cluster Domain in Elp3 Important for the Structural Integrity of Elongator. Journal of Biological Chemistry, 284(1), 141-149. DOI Scopus49 WoS41 Europe PMC36
2009	Selth, L., Gilbert, C., & Svejstrup, J. (2009). RNA immunoprecipitation to determine RNA-protein associations in vivo. Cold Spring Harbor Protocols, 4(6), 1-7. DOI Scopus45 Europe PMC31
2009	Selth, L., Lorch, Y., Ocampo-Hafalla, M., Mitter, R., Shales, M., Krogan, N., . . . Svejstrup, J. (2009). An Rtt109-independent role for Vps75 in transcription-associated nucleosome dynamics. Molecular and Cellular Biology, 29(15), 4220-4234. DOI Scopus26 WoS25 Europe PMC26
2009	Eini Gandomani, O., Dogra, S., Selth, L., Dry, I., Randles, J., & Rezaian, M. (2009). Interaction with a Host Ubiquitin-Conjugating Enzyme Is Required for the Pathogenicity of a Geminiviral DNA beta Satellite. Molecular Plant-Microbe Interactions, 22(6), 737-746. DOI Scopus60 WoS54 Europe PMC38
2007	Selth, L., & Svejstrup, J. (2007). Vps75, a new yeast member of the NAP histone chaperone family. Journal of Biological Chemistry, 282(17), 12358-12362. DOI Scopus61 WoS59 Europe PMC53
2006	Rasheed, M., Selth, L., Koltunow, A., Randles, J., & Rezaian, M. (2006). Single-stranded DNA of Tomato leaf curl virus accumulates in the cytoplasm of phloem cells. Virology, 348(1), 120-132. DOI Scopus24 WoS23 Europe PMC20
2006	Selth, L., Dogra, S., Rasheed, M., Randles, J., & Rezaian, M. (2006). Identification and characterization of a host reversibly glycosylated peptide that interacts with the Tomato leaf curl virus V1 protein. Plant Molecular Biology, 61(1-2), 297-310. DOI Scopus24 WoS20 Europe PMC15
2005	Selth, L., Dogra, S., Rasheed, M., Healy, H., Randles, J., & Rezaian, M. (2005). A NAC domain protein interacts with tomato leaf curl virus replication accessory protein and enhances viral replication. Plant Cell, 17(1), 311-325. DOI Scopus137 WoS122 Europe PMC89
2004	Selth, L., Randles, J., & Rezaian, M. (2004). Host responses to transient expression of individual genes encoded by Tomato leaf curl virus. Molecular Plant-Microbe Interactions, 17(1), 27-33. DOI Scopus44 WoS37 Europe PMC28
2002	Selth, L., Randles, J., & Rezaian, M. (2002). Agrobacterium tumefaciens supports DNA replication of diverse geminivirus types. FEBS Letters, 516(1-3), 179-182. DOI Scopus25 WoS26 Europe PMC23
	Tilley, W., Hickey, T., Selth, L., Chia, K. M., Milioli, H., Laven-Law, G., . . . Carroll, J. (n.d.). The Androgen Receptor is a Tumour Suppressor in Estrogen Receptor Positive Breast Cancer. DOI
	Nassar, Z. D., Mah, C. Y., Dehairs, J., Burvenich, I. J. G., Irani, S., Centenera, M. M., . . . Butler, L. M. (n.d.). DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. DOI

Book Chapters

Year	Citation
2013	Selth, L. A., Townley, S. L., Gillis, J. L., Tilley, W. D., & Butler, L. M. (2013). Identification of Prostate Cancer-Associated MicroRNAs in Circulation Using a Mouse Model of Disease. In Methods in Molecular Biology (pp. 235-246). Humana Press. DOI
2013	Selth, L., Townley, S., Gillis, J., Tilley, W., & Butler, L. (2013). Identification of prostate cancer-associated microRNAs in circulation using a mouse model of disease. In T. Ochiya (Ed.), Circulating MicroRNAs. Methods and Protocols (Vol. 1024, pp. 235-246). UK: Springer. DOI Scopus3 Europe PMC3
2011	Selth, L., Close, T., & Svejstrup, J. (2011). Studying RNA-protein interactions in vivo by RNA immunoprecipitation. In T. Tollefsbol (Ed.), Epigenetics Protocols (Vol. 791, 2 ed., pp. 253-264). United States: Humana Press. DOI Scopus21 Europe PMC17

Conference Papers

Year	Citation
2018	Obinata, D., Lawrence, M., Taylor, R., Sandhu, S., Selth, L., & Risbridger, G. (2018). The efficacy of bromodomain inhibitor for multiple drug resistant CRPC using new patient-derived ex vivo models. In CANCER SCIENCE Vol. 109 (pp. 1024). WILEY.
2018	Selth, L. (2018). Toward Improved Treatment of Prostate Cancer: Novel Strategies to Target the Androgen Receptor. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 14 (pp. 26-27). WILEY.
2017	Nassar, Z. D., Centenera, M. M., Machiels, J., Polacek, S. J., Bloch, K., Tilley, W. D., . . . Butler, L. (2017). Lipid elongation: an unexplored therapeutic target in prostate cancer. In CANCER RESEARCH Vol. 77 (pp. 2 pages). Washington, DC: AMER ASSOC CANCER RESEARCH. DOI
2012	Ochnik, A. M., Moore, N. L., Birrell, S. N., Butler, L. M., Jindal, S., Selth, L., . . . Hickey, T. E. (2012). The combined actions of DHT and MPA lead to altered AR signaling in normal and malignant post-menopausal breast epithelial cells. In Cancer Research Vol. 72 (pp. 2). Chicago, IL: American Association for Cancer Research. DOI

Conference Items

Year	Citation
2020	Butler, L. M., Mah, C. Y., Dehairs, J., Vincent, A., Mutuku, S., Spotbeen, X., . . . Swinnen, J. (2020). Phospholipid profiling of clinical prostate tissues reveals targetable alterations in membrane lipid composition accompanying tumorigenesis. Poster session presented at the meeting of CANCER RESEARCH. ELECTR NETWORK: AMER ASSOC CANCER RESEARCH. DOI
2020	Lim, E., Hickey, T. A., Selth, L. A., Chia, K. M., Milioli, H. H., Roden, D., . . . Tilley, W. D. (2020). The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer. Poster session presented at the meeting of CANCER RESEARCH. San Antonio, TX: AMER ASSOC CANCER RESEARCH. DOI
2020	Shrestha, R. K., Townley, S., Hanson, A., Pickering, M., Nassar, Z. D., Mah, C. Y., . . . Selth, L. A. (2020). ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against oxidative stress.. Poster session presented at the meeting of CANCER RESEARCH. ELECTR NETWORK: AMER ASSOC CANCER RESEARCH. WoS1
2019	Winter, J. M., Mustafa, E. H., Wang, S., Selth, L. A., Hickey, T. E., & Tilley, W. D. (2019). Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro. Poster session presented at the meeting of CANCER RESEARCH. Atlanta, GA: AMER ASSOC CANCER RESEARCH. DOI
2018	Daniel, M. L., Hickey, T. E., Carroll, J. S., Tilley, W. D., Selth, L. A., & Dehm, S. M. (2018). Deciphering the regulome of androgen receptor variants in prostate cancer. Poster session presented at the meeting of CANCER RESEARCH. Chicago, IL: AMER ASSOC CANCER RESEARCH. DOI
2018	Nassar, Z. D., Centenera, M. M., Machiels, J., Zinonos, I., Hanson, A., Bloch, K., . . . Swinnen, J. V. (2018). Lipid elongation in prostate cancer is androgen regulated and a potential therapeutic target. Poster session presented at the meeting of BJU International. Brisbane, Australia: Wiley.
2018	Matin, F., Jeet, V., Moya, L., Selth, L. A., Chambers, S., Clements, J. A., & Batra, J. (2018). A plasma biomarker panel of four microRNAs for the diagnosis of prostate cancer. Poster session presented at the meeting of Abstracts of the 19th Asia-Pacific Prostate Cancer Conference, as published in BJU International. Brisbane, AUSTRALIA: Wiley. DOI
2017	Selth, L. (2017). TOWARDS IMPROVED PROSTATE CANCER TREATMENT BY EXPLOITING MICRORNAS. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
2016	Nassar, Z. D., Centenera, M. M., Machiels, J., Polacek, S. J., Bloch, K., Tilley, W. D., . . . Swinnen, J. V. (2016). Androgenic regulation of lipid elongation in prostate cancer. Poster session presented at the meeting of BJU International. Melbourne: Wiley.
2016	Asim, M., Massie, C., Warren, A., Luko, K., Chohan, B., Menon, S., . . . Neal, D. (2016). Androgen-regulated proteome reveals a therapeutically relevant androgen receptor coactivator target in prostate cancer. Poster session presented at the meeting of CANCER RESEARCH. New Orleans, LA: AMER ASSOC CANCER RESEARCH. DOI
2015	Armstrong, H., Butler, L., Selth, L., Tarulli, G., & Centenera, M. (2015). The Hsp90 inhibitor, NVP-AUY922, produces anti-tumour activity through inhibition of fibronectin polymerization resulting in cytoskeletal reorganization. Poster session presented at the meeting of BJU INTERNATIONAL. Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015	Roberts, M. J., Chow, C. W. K., Schirra, H. J., Richards, R., Buck, M., Selth, L. A., . . . Gardiner, R. A. F. (2015). Diagnostic performance of PCA3, Hepsin and microRNA biomarkers in ejaculate in combination with serum PSA for the detection and triaging of prostate cancer. Poster session presented at the meeting of British Journal of Urology (BJU) International. Adelaide, Australia: Wiley. DOI
2014	Hickey, T. E., Robinson, J. L., Moore, N. L., Russell, R., Selth, L., Rueda, O., . . . Tilley, W. D. (2014). The androgen receptor restricts estrogen receptor Alpha DNA binding in breast cancer cells. Poster session presented at the meeting of Endocrine Reviews. Chicago: Endocrine Society.
2014	Roberts, M., Selth, L., Chow, C., Doi, S., Vincent, A., Butler, L., . . . Gardiner, R. (2014). Seminal fluid microRNAs: new, non-invasive biomarkers for prostate cancer. Poster session presented at the meeting of BJU International. Brisbane: Wiley.
2013	Selth, L., Townley, S., Bert, A., Stricker, P., Sutherland, P., Horvath, L., . . . Tilley, W. (2013). CIRCULATING microRNAs PREDICT BIOCHEMICAL RECURRENCE IN PROSTATE CANCER PATIENTS. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2021	Co-Supervisor	Pathological parameters of positive surgical margins	Doctor of Philosophy	Doctorate	Part Time	Dr Athul Francis John
2019	Principal Supervisor	Elucidating the Interplay Between Androgen Receptor Signalling and Lipid Metabolism in Prostate Cancer	Doctor of Philosophy	Doctorate	Full Time	Ms Meiwen Danielle Fang
2018	Co-Supervisor	Female Germline Formation During Plant Development	Doctor of Philosophy	Doctorate	Full Time	Mr Dayton Christopher Bird

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2017 - 2021	Principal Supervisor	Extreme Activation of Androgen Receptor for Prostate Cancer Therapy	Doctor of Philosophy	Doctorate	Full Time	Mr Mohammadreza Alizadeh Ghodsi
2017 - 2021	Principal Supervisor	Elucidating the molecular mechanisms underlying androgen-regulated lipid metabolism in prostate cancer	Doctor of Philosophy	Doctorate	Full Time	Mr Raj Kumar Shrestha
2016 - 2020	Principal Supervisor	The Role of MicroRNA-194 in Prostate Cancer Progression	Doctor of Philosophy	Doctorate	Full Time	Miss Rayzel Candida Fernandes
2014 - 2014	Principal Supervisor	Curcumin Action in Prostate Cancer Cells and Fibroblasts	Doctor of Philosophy	Doctorate	Full Time	Miss Lauren Giorgio
2014 - 2017	Co-Supervisor	MicroRNA Mediated Gene Regulation in Cancer	Doctor of Philosophy	Doctorate	Full Time	Ms Qingqing Wang
2013 - 2016	Co-Supervisor	Elucidating the Molecular Action of Synthetic Heat Shock Protein 90 Inhibitors in Prostate Cancer	Doctor of Philosophy	Doctorate	Full Time	Miss Heather Krista Armstrong
2013 - 2016	Principal Supervisor	The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis	Doctor of Philosophy	Doctorate	Full Time	Dr Rajdeep Das
2011 - 2015	Co-Supervisor	Combinatorial Targeting of the Androgen Receptor for Prostate Cancer Therapy	Doctor of Philosophy	Doctorate	Full Time	Miss Sarah Carter

Committee Memberships

Date	Role	Committee	Institution
2016 - ongoing	Member	Adelaide Health and Medical School Research Reference Group
2015 - ongoing	Member	Faculty of Health Sciences Early/Mid Career Researcher Working Group	University of Adelaide
2014 - ongoing	Member	University of Adelaide Institutional Biosafety Committee	University of Adelaide

Editorial Boards

Date Role Editorial Board Name Institution Country

2017 - ongoing Board Member Endocrine-Related Cancer

2015 - ongoing Editor Scientific Reports (Nature Publishing Group)

Date	Role	Editorial Board Name	Institution	Country
2017 - ongoing	Board Member	Endocrine-Related Cancer
2015 - ongoing	Editor	Scientific Reports (Nature Publishing Group)

Position: Senior Research Fellow - DRMCRL
Phone: 83137860
Email: luke.selth@adelaide.edu.au
Campus: North Terrace
Building: Adelaide Health and Medical Sciences, floor 8
Org Unit: Medical Specialties

Dr Luke Selth

Appointments

Awards and Achievements

Education

Research Interests