
Dr Luke Selth
Senior Research Fellow - DRMCRL
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Luke Selth
Luke Selth is an Associate Professor at Flinders University and has an Adjunct Associate Professor position associated with the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL), Adelaide Medical School. He is a Cancer Council SA Beat Cancer Principal Cancer Research Fellow in the Flinders Health and Medical Research Institute (FHMRI), where he leads the Prostate Cancer Research Group. He is also member of the Freemasons Centre for Male Health and Wellbeing (FCMHW) and sits on the Scientific Advisory Committee for the South Australian Genomics Centre.
Research in the Selth lab focuses on two aspects of prostate cancer development and progression. The first is aimed at investigating the mechanisms underlying continued androgen signalling in lethal forms of prostate cancer. The second involves research into the role of microRNAs in prostate carcinogenesis and metastasis and their use as potential biomarkers of disease. These research programs utilise contemporary "omic" techniques to better understand prostate cancer at the molecular level.
Selth is a past Young Investigator of Prostate Cancer Foundation of Australia and the Prostate Cancer Foundation (USA). His research is currently funded by competitive grants from various bodies, including Cancer Council SA, Cancer Australia, Movember and The Hospital Research Foundation.
A range of PhD and Honours projects are available in Selth's lab for motivated students - please contact him directly at luke.selth@flinders.edu.au if you are interested.
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Appointments
Date Position Institution name 2019 - ongoing Associate Professor Flinders University 2019 - ongoing Adjunct Associate Professor University of Adelaide 2015 - 2019 Senior Research Fellow University of Adelaide 2009 - 2014 Research Fellow University of Adelaide 2005 - 2009 Post-doctoral Fellow Cancer Research UK London Research Institute -
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Fellowship Endeavour Research Fellowship 2015 Research Award Australian Society for Medical Research Leading Light Award (finalist) 2013 Award South Australian Young Tall Poppy Science Award 2012 Award Prostate Cancer Foundation Young Investigator Award 2011 Award Millennium Sciences Award (Lorne Genome Conference) 2011 Award Prostate Cancer Foundation of Australia Young Investigator Award 2010 Award International Conference Award University of Adelaide Faculty of Health Sciences 2005 Fellowship European Molecular Biology Organisation (EMBO) Long-Term Fellowship -
Education
Date Institution name Country Title 2005 University of Adelaide Australia PhD 2000 Flinders University Australia B. Biotechnology (Honours) -
Research Interests
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Journals
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Book Chapters
Year Citation 2013 Selth, L. A., Townley, S. L., Gillis, J. L., Tilley, W. D., & Butler, L. M. (2013). Identification of Prostate Cancer-Associated MicroRNAs in Circulation Using a Mouse Model of Disease. In Methods in Molecular Biology (pp. 235-246). Humana Press.
2013 Selth, L., Townley, S., Gillis, J., Tilley, W., & Butler, L. (2013). Identification of prostate cancer-associated microRNAs in circulation using a mouse model of disease. In T. Ochiya (Ed.), Circulating MicroRNAs. Methods and Protocols (Vol. 1024, pp. 235-246). UK: Springer.
Scopus3 Europe PMC32011 Selth, L., Close, T., & Svejstrup, J. (2011). Studying RNA-protein interactions in vivo by RNA immunoprecipitation. In T. Tollefsbol (Ed.), Epigenetics Protocols (Vol. 791, 2 ed., pp. 253-264). United States: Humana Press.
Scopus21 Europe PMC17 -
Conference Papers
Year Citation 2018 Obinata, D., Lawrence, M., Taylor, R., Sandhu, S., Selth, L., & Risbridger, G. (2018). The efficacy of bromodomain inhibitor for multiple drug resistant CRPC using new patient-derived ex vivo models. In CANCER SCIENCE Vol. 109 (pp. 1024). WILEY. 2018 Selth, L. (2018). Toward Improved Treatment of Prostate Cancer: Novel Strategies to Target the Androgen Receptor. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 14 (pp. 26-27). WILEY. 2017 Nassar, Z. D., Centenera, M. M., Machiels, J., Polacek, S. J., Bloch, K., Tilley, W. D., . . . Butler, L. (2017). Lipid elongation: an unexplored therapeutic target in prostate cancer. In CANCER RESEARCH Vol. 77 (pp. 2 pages). Washington, DC: AMER ASSOC CANCER RESEARCH.
2012 Ochnik, A. M., Moore, N. L., Birrell, S. N., Butler, L. M., Jindal, S., Selth, L., . . . Hickey, T. E. (2012). The combined actions of DHT and MPA lead to altered AR signaling in normal and malignant post-menopausal breast epithelial cells. In Cancer Research Vol. 72 (pp. 2). Chicago, IL: American Association for Cancer Research.
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Conference Items
Year Citation 2020 Butler, L. M., Mah, C. Y., Dehairs, J., Vincent, A., Mutuku, S., Spotbeen, X., . . . Swinnen, J. (2020). Phospholipid profiling of clinical prostate tissues reveals targetable alterations in membrane lipid composition accompanying tumorigenesis. Poster session presented at the meeting of CANCER RESEARCH. ELECTR NETWORK: AMER ASSOC CANCER RESEARCH.
2020 Lim, E., Hickey, T. A., Selth, L. A., Chia, K. M., Milioli, H. H., Roden, D., . . . Tilley, W. D. (2020). The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer. Poster session presented at the meeting of CANCER RESEARCH. San Antonio, TX: AMER ASSOC CANCER RESEARCH.
2020 Shrestha, R. K., Townley, S., Hanson, A., Pickering, M., Nassar, Z. D., Mah, C. Y., . . . Selth, L. A. (2020). ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against oxidative stress.. Poster session presented at the meeting of CANCER RESEARCH. ELECTR NETWORK: AMER ASSOC CANCER RESEARCH.
WoS12019 Winter, J. M., Mustafa, E. H., Wang, S., Selth, L. A., Hickey, T. E., & Tilley, W. D. (2019). Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro. Poster session presented at the meeting of CANCER RESEARCH. Atlanta, GA: AMER ASSOC CANCER RESEARCH.
2018 Daniel, M. L., Hickey, T. E., Carroll, J. S., Tilley, W. D., Selth, L. A., & Dehm, S. M. (2018). Deciphering the regulome of androgen receptor variants in prostate cancer. Poster session presented at the meeting of CANCER RESEARCH. Chicago, IL: AMER ASSOC CANCER RESEARCH.
2018 Nassar, Z. D., Centenera, M. M., Machiels, J., Zinonos, I., Hanson, A., Bloch, K., . . . Swinnen, J. V. (2018). Lipid elongation in prostate cancer is androgen regulated and a potential therapeutic target. Poster session presented at the meeting of BJU International. Brisbane, Australia: Wiley. 2018 Matin, F., Jeet, V., Moya, L., Selth, L. A., Chambers, S., Clements, J. A., & Batra, J. (2018). A plasma biomarker panel of four microRNAs for the diagnosis of prostate cancer. Poster session presented at the meeting of Abstracts of the 19th Asia-Pacific Prostate Cancer Conference, as published in BJU International. Brisbane, AUSTRALIA: Wiley.
2017 Selth, L. (2017). TOWARDS IMPROVED PROSTATE CANCER TREATMENT BY EXPLOITING MICRORNAS. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY. 2016 Nassar, Z. D., Centenera, M. M., Machiels, J., Polacek, S. J., Bloch, K., Tilley, W. D., . . . Swinnen, J. V. (2016). Androgenic regulation of lipid elongation in prostate cancer. Poster session presented at the meeting of BJU International. Melbourne: Wiley. 2016 Asim, M., Massie, C., Warren, A., Luko, K., Chohan, B., Menon, S., . . . Neal, D. (2016). Androgen-regulated proteome reveals a therapeutically relevant androgen receptor coactivator target in prostate cancer. Poster session presented at the meeting of CANCER RESEARCH. New Orleans, LA: AMER ASSOC CANCER RESEARCH.
2015 Armstrong, H., Butler, L., Selth, L., Tarulli, G., & Centenera, M. (2015). The Hsp90 inhibitor, NVP-AUY922, produces anti-tumour activity through inhibition of fibronectin polymerization resulting in cytoskeletal reorganization. Poster session presented at the meeting of BJU INTERNATIONAL. Cairns, AUSTRALIA: WILEY-BLACKWELL. 2015 Roberts, M. J., Chow, C. W. K., Schirra, H. J., Richards, R., Buck, M., Selth, L. A., . . . Gardiner, R. A. F. (2015). Diagnostic performance of PCA3, Hepsin and microRNA biomarkers in ejaculate in combination with serum PSA for the detection and triaging of prostate cancer. Poster session presented at the meeting of British Journal of Urology (BJU) International. Adelaide, Australia: Wiley.
2014 Hickey, T. E., Robinson, J. L., Moore, N. L., Russell, R., Selth, L., Rueda, O., . . . Tilley, W. D. (2014). The androgen receptor restricts estrogen receptor Alpha DNA binding in breast cancer cells. Poster session presented at the meeting of Endocrine Reviews. Chicago: Endocrine Society. 2014 Roberts, M., Selth, L., Chow, C., Doi, S., Vincent, A., Butler, L., . . . Gardiner, R. (2014). Seminal fluid microRNAs: new, non-invasive biomarkers for prostate cancer. Poster session presented at the meeting of BJU International. Brisbane: Wiley. 2013 Selth, L., Townley, S., Bert, A., Stricker, P., Sutherland, P., Horvath, L., . . . Tilley, W. (2013). CIRCULATING microRNAs PREDICT BIOCHEMICAL RECURRENCE IN PROSTATE CANCER PATIENTS. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Co-Supervisor Pathological parameters of positive surgical margins Doctor of Philosophy Doctorate Part Time Dr Athul Francis John 2019 Principal Supervisor Elucidating the Interplay Between Androgen Receptor Signalling and Lipid Metabolism in Prostate Cancer Doctor of Philosophy Doctorate Full Time Ms Meiwen Danielle Fang 2018 Co-Supervisor Female Germline Formation During Plant Development Doctor of Philosophy Doctorate Full Time Mr Dayton Christopher Bird -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2021 Principal Supervisor Extreme Activation of Androgen Receptor for Prostate Cancer Therapy Doctor of Philosophy Doctorate Full Time Mr Mohammadreza Alizadeh Ghodsi 2017 - 2021 Principal Supervisor Elucidating the molecular mechanisms underlying androgen-regulated lipid metabolism in prostate cancer Doctor of Philosophy Doctorate Full Time Mr Raj Kumar Shrestha 2016 - 2020 Principal Supervisor The Role of MicroRNA-194 in Prostate Cancer Progression Doctor of Philosophy Doctorate Full Time Miss Rayzel Candida Fernandes 2014 - 2014 Principal Supervisor Curcumin Action in Prostate Cancer Cells and Fibroblasts Doctor of Philosophy Doctorate Full Time Miss Lauren Giorgio 2014 - 2017 Co-Supervisor MicroRNA Mediated Gene Regulation in Cancer Doctor of Philosophy Doctorate Full Time Ms Qingqing Wang 2013 - 2016 Co-Supervisor Elucidating the Molecular Action of Synthetic Heat Shock Protein 90 Inhibitors in Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Heather Krista Armstrong 2013 - 2016 Principal Supervisor The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Rajdeep Das 2011 - 2015 Co-Supervisor Combinatorial Targeting of the Androgen Receptor for Prostate Cancer Therapy Doctor of Philosophy Doctorate Full Time Miss Sarah Carter
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Committee Memberships
Date Role Committee Institution Country 2016 - ongoing Member Adelaide Health and Medical School Research Reference Group 2015 - ongoing Member Faculty of Health Sciences Early/Mid Career Researcher Working Group University of Adelaide 2014 - ongoing Member University of Adelaide Institutional Biosafety Committee University of Adelaide -
Editorial Boards
Date Role Editorial Board Name Institution Country 2017 - ongoing Board Member Endocrine-Related Cancer 2015 - ongoing Editor Scientific Reports (Nature Publishing Group)
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