Dr Laura Weyrich

Laura Weyrich
ARC Postdoctoral Research Associate
School of Biological Sciences
Faculty of Sciences

My research aims to reconstruct the human microbiome in the past using ancient DNA techniques. We are actively reconstructing oral microbial communities from ancient humans on six continents over the past 20,000 years. Our goal is to describe how and why microbial communities in the human body adapt and change in response to alterations in lifestyle, diet, and environment. Understanding these changes may allow us to develop novel treatment strategies to prevent or cure many microbiome-associated diseases in modern populations, such as obesity, diabetes, arthritis, cancer, and poor oral health.

A quick overview of my research can be found here:
https://www.youtube.com/watch?v=-N1Ma7TBIAw

Connect with me

Other links

Dr Laura Weyrich

My research aims to reconstruct the human microbiome in the past using ancient DNA techniques. We are actively reconstructing oral microbial communities from ancient humans on six continents over the past 20,000 years. Our goal is to describe how and why microbial communities in the human body adapt and change in response to alterations in lifestyle, diet, and environment. Understanding these changes may allow us to develop novel treatment strategies to prevent or cure many microbiome-associated diseases in modern populations, such as obesity, diabetes, arthritis, cancer, and poor oral health.

A quick overview of my research can be found here:
https://www.youtube.com/watch?v=-N1Ma7TBIAw

Appointments

Date Position Institution name
2012 ARC Discovery Early Career Research Award Fellow University of Adelaide

Education

Date Institution name Country Title
South Dakota State University United States B.Sc. Microbiology
The Pennsylvania State University United States PhD Biochemistry, Microbiology, and Molecular Biology, and Bioethics

Research Interests

Aboriginal and Torres Strait Islander Archaeology, Aboriginal and Torres Strait Islander Health, Anthropological Genetics, Dentistry, Microbial Ecology, Microbial Genetics, Traditional Aboriginal and Torres Strait Islander Medicine and Treatments

Journals

Year Citation
2017 van den Elsen, L. W., Poyntz, H. C., Weyrich, L. S., Young, W. & Forbes-Blom, E. E. (2017). Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases. Clinical & Translational Immunology, 6, 1, e125-e125.
10.1038/cti.2016.91
2017 Frisia, S., Weyrich, L., Hellstrom, J., Borsato, A., Golledge, N., Anesio, A. ... Cooper, A. (2017). The influence of Antarctic subglacial volcanism on the global iron cycle during the Last Glacial Maximum. Nature Communications, 8, -.
10.1038/ncomms15425
2017 Young, J., Austin, J. & Weyrich, L. (2017). Soil DNA metabarcoding and high-throughput sequencing as a forensic tool: considerations, potential limitations and recommendations. K. Smalla (Ed.). FEMS Microbiology Ecology, 93, 2, 207-1-207-8.
10.1093/femsec/fiw207
2017 Llamas, B., Valverde, G., Fehren-Schmitz, L., Weyrich, L. S., Cooper, A. & Haak, W. (2017). From the field to the laboratory: Controlling DNA contamination in human ancient DNA research in the high-throughput sequencing era. STAR: Science & Technology of Archaeological Research, 3, 1, 1-14.
10.1080/20548923.2016.1258824
2017 Mills, J., Weinstein, P., Gellie, N., Weyrich, L., Lowe, A. & Breed, M. (2017). Urban habitat restoration provides a human health benefit through microbiome rewilding: The Microbiome Rewilding Hypothesis. Restoration Ecology, -.
10.1111/rec.12610
2017 Shaw, J., Weyrich, L. & Cooper, A. (2017). Using environmental (e)DNA sequencing for aquatic biodiversity surveys: A beginner's guide. Marine and Freshwater Research, 68, 1, 20-33.
10.1071/MF15361
2017 Weyrich, L., Duchene, S., Soubrier, J., Arriola, L., Llamas, B., Breen, J. ... Soltysiak, A. (2017). Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus. Nature, 544, 7650, 357-361.
10.1038/nature21674
2017 Eisenhofer, R., Cooper, A. & Weyrich, L. (2017). Reply to santiago-rodriguez et al.: Proper authentication of ancient DNA is essential. FEMS Microbiology Ecology, 93, 5, -.
10.1093/femsec/fix042
2016 Shaw, J., Clarke, L., Wedderburn, S., Barnes, T., Weyrich, L. & Cooper, A. (2016). Comparison of environmental DNA metabarcoding and conventional fish survey methods in a river system. Biological Conservation, 197, 131-138.
10.1016/j.biocon.2016.03.010
2016 Abdul-Aziz, M., Cooper, A. & Weyrich, L. (2016). Exploring relationships between host genome and microbiome: new insights from genome-wide association studies. Bosch,Thomas C. (Ed.). Frontiers in Microbiology, 7, OCT, 1611-1-1611-9.
10.3389/fmicb.2016.01611
2016 Young, J., Weyrich, L. & Cooper, A. (2016). High-throughput sequencing of trace quantities of soil provides reproducible and discriminative fungal DNA profiles. Journal of Forensic Sciences, 61, 2, 478-484.
10.1111/1556-4029.12996
2016 Eisenhofer Philipona, R., Cooper, A. & Weyrich, L. (2016). Isolating viable ancient bacteria: what you put in is what you get out. Genome Announcements, 4, 4, e00712-16-e00712-16.
10.1128/genomeA.00712-16
2015 Shaw, J., Monis, P., Weyrich, L., Sawade, E., Drikas, M. & Cooper, A. (2015). Using amplicon sequencing to characterize and monitor bacterial diversity in drinking water distribution systems. D. Schaffner (Ed.). Applied and Environmental Microbiology, 81, 18, 6463-6473.
10.1128/AEM.01297-15
2015 Jervis-Bardy, J., Rogers, G., Morris, P., Smith-Vaughan, H., Nosworthy, E., Leong, L. ... Marsh, R. (2015). The microbiome of otitis media with effusion in Indigenous Australian children. International Journal of Pediatric Otorhinolaryngology, 79, 9, 1548-1555.
10.1016/j.ijporl.2015.07.013
2015 Clarke, L., Weyrich, L. & Cooper, A. (2015). Reintroduction of locally extinct vertebrates impacts arid soil fungal communities. Molecular Ecology, 24, 12, 3194-3205.
10.1111/mec.13229
2015 Bendor, L., Weyrich, L., Linz, B., Rolin, O., Taylor, D., Goodfield, L. ... Harvill, E. (2015). Type six secretion system of Bordetella bronchiseptica and adaptive immune components limit intracellular survival during infection. S. Jeyaseelan (Ed.). PloS One, 10, 10, 1-17.
10.1371/journal.pone.0140743
2015 Weyrich, L., Dobney, K. & Cooper, A. (2015). Ancient DNA analysis of dental calculus. Journal of Human Evolution, 79, 119-124.
10.1016/j.jhevol.2014.06.018
2015 Cooper, A., Weyrich, L., Dixit, S. & Farrer, A. (2015). The skin microbiome: Associations between altered microbial communities and disease. Australasian Journal of Dermatology, 56, 4, 268-274.
10.1111/ajd.12253
2015 Young, J., Weyrich, L., Breen, J., Macdonald, L. & Cooper, A. (2015). Predicting the origin of soil evidence: High throughput eukaryote sequencing and MIR spectroscopy applied to a crime scene scenario. Forensic Science International, 251, 22-31.
10.1016/j.forsciint.2015.03.008
2015 Young, J., Weyrich, L., Clarke, L. & Cooper, A. (2015). Residual soil DNA extraction increases the discriminatory power between samples. Forensic Science, Medicine, and Pathology, 11, 2, 268-272.
10.1007/s12024-015-9662-z
2014 Clarke, L., Soubrier, J., Weyrich, L. & Cooper, A. (2014). Environmental metabarcodes for insects: In silico PCR reveals potential for taxonomic bias. Molecular Ecology Resources, 14, 6, 1160-1170.
10.1111/1755-0998.12265
2014 Weyrich, L., Llamas, B. & Cooper, A. (2014). Reply to Santiago-Rodriguez et al.: Was luxS really isolated from 25- to 40-million-year-old bacteria?. FEMS Microbiology Letters, 353, 2, 85-86.
10.1111/1574-6968.12415
2014 Weyrich, L., Feaga, H., Park, J., Muse, S., Safi, C., Rolin, O. ... Harvill, E. (2014). Resident microbiota affect bordetella pertussis infectious dose and host specificity. Journal of Infectious Diseases, 209, 6, 913-921.
10.1093/infdis/jit597
2014 Young, J., Rawlence, N., Weyrich, L. & Cooper, A. (2014). Limitations and recommendations for successful DNA extraction from forensic soil samples: a review. Science and Justice, 54, 3, 238-244.
10.1016/j.scijus.2014.02.006
2014 Young, J., Weyrich, L. & Cooper, A. (2014). Forensic soil DNA analysis using high-throughput sequencing: a comparison of four molecular markers. Forensic Science International: Genetics, 13, 176-184.
10.1016/j.fsigen.2014.07.014
2013 Adler, C., Dobney, K., Weyrich, L., Kaidonis, J., Walker, A., Haak, W. ... Cooper, A. (2013). Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions. Nature Genetics, 45, 4, 450-455.
10.1038/ng.2536
2013 Weyrich, L. & Harvill, E. (2013). Teaching ethical aptitude to graduate student researchers. Accountability in Research: policies and quality assurance, 20, 1, 5-12.
10.1080/08989621.2013.749742
2012 Weyrich, L., Rolin, O., Muse, S., Park, J., Spidale, N., Kennett, M. ... Harvill, E. (2012). A type VI secretion system encoding locus is required for bordetella bronchiseptica immunomodulation and persistence in vivo. I. Boneca (Ed.). PLoS One, 7, 10, e45892-1-e45892-12.
10.1371/journal.pone.0045892
2012 Zhang, X., Weyrich, L., Lavine, J., Karanikas, A. & Harvill, E. (2012). Lack of cross-protection against Bordetella holmesii after pertussis vaccination. Emerging Infectious Diseases, 18, 11, 1771-1779.
10.3201/eid1811.111544
2009 Buboltz, A., Nicholson, T., Weyrich, L. & Harvill, E. (2009). Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica. Infection and Immunity, 77, 9, 3969-3977.
10.1128/IAI.01362-08

Conference Papers

Year Citation
2016 Poyntz, H., Robinson, M., Pitt, L., Everitt, C., Jones, A., Plunkett, C. ... Forbes-Blom, E. (2016). Early life host-microbiota interactions have lifelong consequences for humoral immunity. International Congress of Immunology (ICI). Melbourne, AUSTRALIA.

Conference Items

Year Citation
2015 Farrer, A. G., Weyrich, L. S. & Cooper, A. (2015). Ancient DNA studies provide a basis for medical research. 2015 ASMR SA Scientific Meeting. National Wine Centre, University of Adelaide, South Australia.
2015 Miller, C., Franks, C., Breen, J., Weyrich, L., Soubrier, J., Llamas, B. ... Cooper, A. (2015). Open access to ancient human DNA: An Australian Centre for Ancient DNA (ACAD) and University Libraries collaboration. eResearch Australasia. Brisbane, Australia.
Position
ARC Postdoctoral Research Associate
Phone
83135565
Fax
8313 4364
Campus
North Terrace
Building
Darling Building
Room Number
2 05c
Org Unit
Genetics & Evolution

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