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Dr Laura Weyrich

Laura Weyrich
ARC Future Fellow
School of Biological Sciences
Faculty of Sciences

My research aims to reconstruct the human microbiome in the past using ancient DNA techniques. We are actively reconstructing oral microbial communities from ancient humans on six continents over the past 20,000 years. Our goal is to describe how and why microbial communities in the human body adapt and change in response to alterations in lifestyle, diet, and environment. Understanding these changes may allow us to develop novel treatment strategies to prevent or cure many microbiome-associated diseases in modern populations, such as obesity, diabetes, arthritis, cancer, and poor oral health.

A quick overview of my research can be found here: https://www.youtube.com/watch?v=-N1Ma7TBIAw.

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Dr Laura Weyrich

My research aims to reconstruct the human microbiome in the past using ancient DNA techniques. We are actively reconstructing oral microbial communities from ancient humans on six continents over the past 20,000 years. Our goal is to describe how and why microbial communities in the human body adapt and change in response to alterations in lifestyle, diet, and environment. Understanding these changes may allow us to develop novel treatment strategies to prevent or cure many microbiome-associated diseases in modern populations, such as obesity, diabetes, arthritis, cancer, and poor oral health.

A quick overview of my research can be found here: https://www.youtube.com/watch?v=-N1Ma7TBIAw.

Eligible to supervise Masters and PhD, but is currently at capacity — email supervisor to discuss availability.

Appointments

Date Position Institution name
2018 ARC Future Fellow University of Adelaide
2018 - 2015 ARC Post-Doctoral Research Associate University of Adelaide
2018 Node Leader Centre of Excellence for Australian Biodiveristy and Heritage
2016 Metagenomics Research Cluster Lead Australian Centre for Ancient DNA
2015 - 2018 ARC Discovery Early Career Research Award Fellow University of Adelaide

Education

Date Institution name Country Title
The Pennsylvania State University United States PhD Biochemistry, Microbiology, and Molecular Biology, and Bioethics
South Dakota State University United States B.Sc. Microbiology

Research Interests

Journals

Year Citation
2018 Boast, A., Weyrich, L., Wood, J., Metcalf, J., Knight, R., & Cooper, A. (2018). Coprolites reveal ecological interactions lost with the extinction of New Zealand birds. Proceedings of the National Academy of Sciences, 115(7), 1546-1551.
DOI Scopus4 WoS4 Europe PMC3
2018 Eisenhofer, R., & Weyrich, L. (2018). Proper authentication of ancient DNA is still essential. Genes, 9(3), 5 pages.
DOI Scopus2 WoS1 Europe PMC1
2018 Skelly, E., Kapellas, K., Cooper, A., & Weyrich, L. (2018). Consequences of colonialism: A microbial perspective to contemporary Indigenous health. American Journal of Physical Anthropology, 167(2), 423-437.
DOI
2018 Poyntz, H., Jones, A., Jauregui, R., Young, W., Gestin, A., Mooney, A., . . . Forbes-Blom, E. (2018). Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice. Immunology and Cell Biology.
DOI
2017 Shaw, J., Weyrich, L., & Cooper, A. (2017). Using environmental (e)DNA sequencing for aquatic biodiversity surveys: A beginner's guide. Marine and Freshwater Research, 68(1), 20-33.
DOI Scopus6 WoS5
2017 Weyrich, L., Duchene, S., Soubrier, J., Arriola, L., Llamas, B., Breen, J., . . . Cooper, A. (2017). Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus. Nature, 544(7650), 357-361.
DOI Scopus52 WoS39 Europe PMC26
2017 Llamas, B., Valverde, G., Fehren-Schmitz, L., Weyrich, L. S., Cooper, A., & Haak, W. (2017). From the field to the laboratory: Controlling DNA contamination in human ancient DNA research in the high-throughput sequencing era. STAR: Science & Technology of Archaeological Research, 3(1), 1-14.
DOI
2017 Young, J., Austin, J., & Weyrich, L. (2017). Soil DNA metabarcoding and high-throughput sequencing as a forensic tool: considerations, potential limitations and recommendations. FEMS Microbiology Ecology, 93(2), 207-1-207-8.
DOI Scopus4 WoS3 Europe PMC2
2017 Frisia, S., Weyrich, L., Hellstrom, J., Borsato, A., Golledge, N., Anesio, A., . . . Cooper, A. (2017). The influence of Antarctic subglacial volcanism on the global iron cycle during the Last Glacial Maximum. Nature Communications, 8, 9 pages.
DOI Scopus4 WoS4
2017 Mills, J., Weinstein, P., Gellie, N., Weyrich, L., Lowe, A., & Breed, M. (2017). Urban habitat restoration provides a human health benefit through microbiome rewilding: the Microbiome Rewilding Hypothesis. Restoration Ecology, 25(6), 866-872.
DOI Scopus4 WoS2
2017 Eisenhofer, R., Cooper, A., & Weyrich, L. (2017). Reply to santiago-rodriguez et al.: Proper authentication of ancient DNA is essential. FEMS Microbiology Ecology, 93(5), 3 pages.
DOI Scopus2 WoS3 Europe PMC2
2017 van den Elsen, L., Poyntz, H., Weyrich, L., Young, W., & Forbes-Blom, E. (2017). Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases. Clinical & Translational Immunology, 6(1), e125-1-e125-9.
DOI Scopus23
2017 Eisenhofer, R., Anderson, A., Dobney, K., Cooper, A., & Weyrich, L. (2017). Ancient Microbial DNA in Dental Calculus: A New method for Studying Rapid Human Migration Events. Journal of Island and Coastal Archaeology, Online, 1-14.
DOI
2016 Eisenhofer Philipona, R., Cooper, A., & Weyrich, L. (2016). Isolating viable ancient bacteria: what you put in is what you get out. Genome Announcements, 4(4), e00712-16.
DOI Scopus1 Europe PMC1
2016 Abdul-Aziz, M., Cooper, A., & Weyrich, L. (2016). Exploring relationships between host genome and microbiome: new insights from genome-wide association studies. Frontiers in Microbiology, 7(OCT), 1611-1-1611-9.
DOI Scopus6 WoS6 Europe PMC4
2016 Young, J., Weyrich, L., & Cooper, A. (2016). High-throughput sequencing of trace quantities of soil provides reproducible and discriminative fungal DNA profiles. Journal of Forensic Sciences, 61(2), 478-484.
DOI Scopus5 WoS2
2016 Shaw, J., Clarke, L., Wedderburn, S., Barnes, T., Weyrich, L., & Cooper, A. (2016). Comparison of environmental DNA metabarcoding and conventional fish survey methods in a river system. Biological Conservation, 197, 131-138.
DOI Scopus35 WoS28
2015 Weyrich, L., Dobney, K., & Cooper, A. (2015). Ancient DNA analysis of dental calculus. Journal of Human Evolution, 79, 119-124.
DOI Scopus34 WoS29 Europe PMC14
2015 Cooper, A., Weyrich, L., Dixit, S., & Farrer, A. (2015). The skin microbiome: Associations between altered microbial communities and disease. Australasian Journal of Dermatology, 56(4), 268-274.
DOI Scopus26 WoS23 Europe PMC16
2015 Young, J., Weyrich, L., Clarke, L., & Cooper, A. (2015). Residual soil DNA extraction increases the discriminatory power between samples. Forensic Science, Medicine, and Pathology, 11(2), 268-272.
DOI Scopus4 WoS5 Europe PMC1
2015 Young, J., Weyrich, L., Breen, J., Macdonald, L., & Cooper, A. (2015). Predicting the origin of soil evidence: High throughput eukaryote sequencing and MIR spectroscopy applied to a crime scene scenario. Forensic Science International, 251, 22-31.
DOI Scopus12 WoS8 Europe PMC5
2015 Clarke, L., Weyrich, L., & Cooper, A. (2015). Reintroduction of locally extinct vertebrates impacts arid soil fungal communities. Molecular Ecology, 24(12), 3194-3205.
DOI Scopus11 WoS10 Europe PMC3
2015 Shaw, J., Monis, P., Weyrich, L., Sawade, E., Drikas, M., & Cooper, A. (2015). Using amplicon sequencing to characterize and monitor bacterial diversity in drinking water distribution systems. Applied and Environmental Microbiology, 81(18), 6463-6473.
DOI Scopus18 WoS16 Europe PMC10
2015 Jervis-Bardy, J., Rogers, G., Morris, P., Smith-Vaughan, H., Nosworthy, E., Leong, L., . . . Marsh, R. (2015). The microbiome of otitis media with effusion in Indigenous Australian children. International Journal of Pediatric Otorhinolaryngology, 79(9), 1548-1555.
DOI Scopus11 WoS12 Europe PMC12
2015 Bendor, L., Weyrich, L., Linz, B., Rolin, O., Taylor, D., Goodfield, L., . . . Harvill, E. (2015). Type six secretion system of Bordetella bronchiseptica and adaptive immune components limit intracellular survival during infection. PloS One, 10(10), 1-17.
DOI Scopus4 Europe PMC2
2014 Young, J., Rawlence, N., Weyrich, L., & Cooper, A. (2014). Limitations and recommendations for successful DNA extraction from forensic soil samples: a review. Science and Justice, 54(3), 238-244.
DOI Scopus25 WoS20 Europe PMC7
2014 Young, J., Weyrich, L., & Cooper, A. (2014). Forensic soil DNA analysis using high-throughput sequencing: a comparison of four molecular markers. Forensic Science International: Genetics, 13, 176-184.
DOI Scopus26 WoS21 Europe PMC12
2014 Clarke, L., Soubrier, J., Weyrich, L., & Cooper, A. (2014). Environmental metabarcodes for insects: In silico PCR reveals potential for taxonomic bias. Molecular Ecology Resources, 14(6), 1160-1170.
DOI Scopus75 WoS69 Europe PMC7
2014 Weyrich, L., Llamas, B., & Cooper, A. (2014). Reply to Santiago-Rodriguez et al.: Was luxS really isolated from 25- to 40-million-year-old bacteria?. FEMS Microbiology Letters, 353(2), 85-86.
DOI Scopus6 WoS5 Europe PMC5
2014 Weyrich, L., Feaga, H., Park, J., Muse, S., Safi, C., Rolin, O., . . . Harvill, E. (2014). Resident microbiota affect bordetella pertussis infectious dose and host specificity. Journal of Infectious Diseases, 209(6), 913-921.
DOI Scopus12 Europe PMC11
2013 Adler, C., Dobney, K., Weyrich, L., Kaidonis, J., Walker, A., Haak, W., . . . Cooper, A. (2013). Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions. Nature Genetics, 45(4), 450-455.
DOI Scopus192 WoS165 Europe PMC129
2013 Weyrich, L., & Harvill, E. (2013). Teaching ethical aptitude to graduate student researchers. Accountability in Research: policies and quality assurance, 20(1), 5-12.
DOI Scopus5 Europe PMC1
2012 Zhang, X., Weyrich, L., Lavine, J., Karanikas, A., & Harvill, E. (2012). Lack of cross-protection against Bordetella holmesii after pertussis vaccination. Emerging Infectious Diseases, 18(11), 1771-1779.
DOI Scopus13 Europe PMC10
2012 Weyrich, L., Rolin, O., Muse, S., Park, J., Spidale, N., Kennett, M., . . . Harvill, E. (2012). A type VI secretion system encoding locus is required for bordetella bronchiseptica immunomodulation and persistence in vivo. PLoS One, 7(10), e45892-1-e45892-12.
DOI Scopus17 Europe PMC12
2009 Buboltz, A., Nicholson, T., Weyrich, L., & Harvill, E. (2009). Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica. Infection and Immunity, 77(9), 3969-3977.
DOI Scopus24 Europe PMC18

Book Chapters

Year Citation
2018 Weyrich, L. (2018). The history of the human microbiome: Insights from archaeology and ancient DNA. In S. Pilaar Birch (Ed.), Multispecies Archaeology (pp. 230-250). United Kingdom: Routledge.
DOI

Conference Papers

Year Citation
2016 Poyntz, H., Robinson, M., Pitt, L., Everitt, C., Jones, A., Plunkett, C., . . . Forbes-Blom, E. (2016). Early life host-microbiota interactions have lifelong consequences for humoral immunity. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 291). Melbourne, AUSTRALIA: WILEY-BLACKWELL.

Conference Items

Year Citation
2017 Mills, J. G., Weinstein., Gellie., Weyrich., Lowe., & Breed. (2017). Restoration of urban green spaces rewilds the environmental microbiome with associated shifts in the human microbiome.. Poster session presented at the meeting of Society for Ecological Restoration. Foz do Iguacu, Brazil.
2017 Weyrich, L., Dobney, K., & Cooper, A. (2017). Insights from Neandertals and beyond: Evolution of the hominin microbiome on a global scale. Poster session presented at the meeting of Abstracts of the 86th Annual Meeting of the American Association of Physical Anthropologists (AAPA), as published in American Journal of Physical Anthropology. New Orleans, LA: Wiley-Liss.
DOI
2015 Miller, C., Franks, C., Breen, J., Weyrich, L., Soubrier, J., Llamas, B., . . . Cooper, A. (2015). Open access to ancient human DNA: An Australian Centre for Ancient DNA (ACAD) and University Libraries collaboration. Poster session presented at the meeting of Proceedings of eResearch Australasia 2016. Brisbane, Australia: eResearch Australasia.
2015 Farrer, A. G., Weyrich, L. S., & Cooper, A. (2015). Ancient DNA studies provide a basis for medical research. Poster session presented at the meeting of 2015 ASMR SA Scientific Meeting. National Wine Centre, University of Adelaide, South Australia.

Filesets

Year Citation
Weyrich, L., Farrer, A., Philipona, R. E., Handsley-Davis, M., Martinez, L. A., Young, J., . . . Breen, J. (n.d.). Laboratory contamination over time during low-biomass sample analysis.
DOI

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Principal Supervisor Health, History and Ethics: A Multidisciplinary Study of Modern and Historical Microbial Communities in Indigenous Australians Doctor of Philosophy Doctorate Full Time Ms Matilda Handsley-Davis
2018 Principal Supervisor Genomic Adaptation in Indigenous Populations of Sahul and Island Southeast Asia Master of Philosophy Master Full Time Miss Gina Lucille Guzzo
2017 Principal Supervisor Low Biomass Microbiome Research in Health Doctor of Philosophy Doctorate Full Time Miss Caitlin Alyssa Selway
2017 Principal Supervisor Assessing the Role of Mucosal MIcrobiomes in Fish Health Doctor of Philosophy Doctorate Full Time Mr Thibault Philippe Raymond Albert Legrand
2016 Principal Supervisor Human Oral Microbiome Analysis Doctor of Philosophy Doctorate Full Time Ms Emily Jean Skelly
2016 Co-Supervisor Role of Epigenetic Modification and Niobium Evolution in Boind Adaption to Environmental Change Doctor of Philosophy Doctorate Full Time Ms Yichen Liu
2015 Principal Supervisor Genomic and Metagenomic Alterations and Impacts on Disease through time using Ancient DNA Doctor of Philosophy Doctorate Full Time Mr Muslihudeen Abdul-Razaq Abdul-Aziz
2014 Co-Supervisor Genomic evolution of pathogenic oral microbial in homo sapiens using DNA samples from ancient and modern dental Doctor of Philosophy Doctorate Full Time Mr Luis Arriola

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2015 - 2018 Principal Supervisor New and Refined Tools and Guidelines to Expand the Scope and Improve the Reproducibility of Palaeomicrobiological Research Doctor of Philosophy Doctorate Full Time Mr Raphael Alexandre Eisenhofer Philipona
2014 - 2016 Co-Supervisor Ancient DNA of New Zealand's extinct avifauna: Using next-generation sequencing (NGS) to research the paleoecology of the megaherbivore moa (Aves: Dinornithiformes) and the phylogenetics of the enigmatic gruiform Aptornis (Aves: Aptornithidae) Master of Philosophy Master Full Time Mr Alexander Peter Boast
2014 - 2015 Co-Supervisor Metagenomic amplicon sequencing as a rapid and high-throughput tool for aquatic biodiversity surveys Doctor of Philosophy Doctorate Full Time Miss Jennifer Shaw
2013 - 2017 Co-Supervisor Ancient DNA Studies of Dental Calculus Doctor of Philosophy Doctorate Full Time Mr Andrew Graham Farrer
2013 - 2014 Co-Supervisor Application of DNA metabarcoding and high-throughput sequencing for enhanced forensic soil DNA analysis Doctor of Philosophy Doctorate Full Time Miss Jennifer Young
Position
ARC Future Fellow
Phone
83133997
Fax
8313 4364
Campus
North Terrace
Building
Darling, floor 2
Room Number
212A
Org Unit
Molecular and Biomedical Science

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