Laura Eadie

Laura Eadie

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr Laura Eadie is a mid-career researcher having completed her PhD in Medicine in 2013 with a Dean’s Commendation. Laura’s research has always centred on translating laboratory findings to improve patient outcomes. She has spent ten+ years researching modes of resistance to chronic myeloid leukaemia drugs with her efforts resulting in nine first-author publications and presentations at over 25 national and international meetings. She is the tenth recipient of the Peter Nelson Leukaemia Research Fellowship and her research now focuses on high-risk acute lymphoblastic leukaemia (ALL). She is a passionate science communicator and advocate for women in STEM careers. Laura was a 2016 Fulbright Postdoctoral Fellow and was invited to take part in the first TEDx-Fulbright Adelaide event (2019).

Acute Lymphoblastic Leukaemia (ALL) is an extremely heterogeneous disease with subtypes of patients exhibiting a diverse range of genetic mutations. Certain subtypes of ALL can be treated with drugs already in clinical use. Laura undertook her Fulbright fellowship (2016-2017) at St. Jude Children’s Research Hospital in Memphis, Tennessee where she learned mouse models of high-risk ALL. Laura is now leading in vivo mouse studies for high-risk ALL with a specific focus on T-cell ALL. Laura’s research seeks to pave the way for alternative T-ALL therapies that are more effective and have fewer long-term side effects. She is using cutting edge laboratory models to evaluate precision medicine treatment strategies tailored to individual patients. Her current funding will help her and her team create a repository of cells, enabling experimentation and evaluation of the success of different T-ALL targeted therapies.

Long term, Laura aims to provide clinicians with a suite of new and re-purposed FDA-approved drugs, which will be able to effectively treat the different genetic lesions associated with T-ALL.

Acute Lymphoblastic Leukaemia (ALL) is one of the biggest causes of non-traumatic death in children and relapsed T-cell ALL (T-ALL) is an extremely high risk disease. Currently, up to 30% of paediatric/adolescent T-ALL patients relapse with subsequent poor overall survival; the outcome is worse for adult patients with long-term survival rates after relapse below 10%. More effective, less toxic treatments are urgently needed for when a patient fails their front-line chemotherapy. Dr Eadie is SAHMRI's T-ALL research leader and her team creates humanised mouse avatars from individual patient’s leukaemic cells to use in pre-clinical drug trials. Combined with genomic sequencing to identify a patient’s leukaemia-causing mutations, these models allow Dr Eadie to discover more effective therapeutic options targeted to each individual patient’s leukaemia.

T-ALL is characterised by recurrent gene fusions and concomitant structural abnormalities. Ongoing advances in next generation sequencing (NGS) have enabled classification of a diverse range of genomic alterations resulting in new T-ALL subtypes. Critically, the wealth of genomic information available has identified new and recurrent genomic lesions but their biological and clinical implications remain unclear. Incorporating the knowledge gained through NGS into clinical care presents a major challenge.

Dr Eadie's long-term research goal is to identify new and re-purposed drugs which effectively treat the different genetic lesions associated with T-ALL. Her team's findings will ultimately provide clinicians with an arsenal of alternative treatment options and hope for patients who have relapsed.

Research Projects - Dr Laura Eadie

Title: Evaluation of novel alterations in pre-clinical models of T-cell Acute Lymphoblastic Leukaemia (T-ALL)

Project description:

Dr Eadie's research program utilises genomic sequencing to identify novel and targetable T-ALL alterations to accelerate a transition towards precision medicine to improve clinical outcomes. Dr Eadie's Research Group is part of the SAHMRI ALL Genomics and Functional Genomics/Biology Laboratory led by Prof Deborah White (leader, SAHMRI Precision Cancer Medicine Theme). Together, with the ALL bioinformatic team, Dr Eadie has curated the largest genomic sequencing database of T-ALL patients in Australia. Dr Eadie has identified novel leukaemia-causing alterations as well as new treatment options for several high-risk ALL subtypes. 

SAHMRI's ALL Research laboratory is the National Referral Centre for genomic screening of ALL cases allowing identification of genomic alterations in a large number of patients from Australia and New Zealand. Identification of novel and recurrent genomic alterations is ongoing and we have projects available to characterise these alterations in vitro and in vivo.

The over-arching focus of Dr Eadie's research program is the generation of patient-derived xenograft (PDX) and transgenic mouse models of T-ALL from patient samples received in the laboratory. These models are used to (1) examine re-purposing drugs and test novel therapies; and (2) provide therapeutic options for pre-emptive intervention in the case of therapy-resistant disease.

Projects available for:  HDR: Mphil / PhD

Location: SAHMRI

Research project start: Semester 1 or 2

Special requirements: Police Clearance

  • Appointments

    Date Position Institution name
    2020 - ongoing Affiliate Senior Lecturer University of Adelaide
    2019 - ongoing Peter Nelson Post-doctoral Research Fellow SAHMRI
    2016 - 2017 Post-doctoral Research Associate St. Jude Children's Research Hospital
    2014 - 2020 Affiliate Lecturer University of Adelaide
    2013 - 2019 Post-doctoral Researcher SAHMRI
    2013 - 2013 Post-doctoral Researcher SA Pathology
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2020 Award American Society of Hematology (ASH) Abstract Achievement Award American Society of Hematology United States -
    2020 Award CASS Foundation Travel Grant The CASS Foundation Australia $3500
    2019 Invitation Spot the Bull Science The Science Nation Australia -
    2019 Award The Hospital Research Foundation Research Travel Awards The Hospital Research Foundation Australia $4000
    2019 Invitation TEDxFulbright Oration: The Secret Life of a Scientist SAHMR Australia -
    2019 Fellowship Peter Nelson Leukaemia Research Fellowship SAHRMI Australia 300000
    2019 Fellowship Cancer Council SA Beat Cancer Project Mid-Career Cancer Research Fellowship (unable to accept) SAHMRI Australia 300000
    2018 Invitation Invited Speaker: Early/Mid-Career Researcher Seminar Series The University of Adelaide Australia -
    2016 Invitation Judge: European Molecular Biology Laboratory (EMBL) Australian Postgraduate Symposium (EAPS) - - -
    2016 Invitation Invited Speaker: 18th Annual ESH-iCMLF International Conference on CML – Biology and Therapy - - -
    2016 Invitation Invited Speaker: 18th Annual ESH-iCMLF International Conference on CML – Biology and Therapy - - -
    2016 Scholarship Australian-American Fulbright Postdoctoral Scholarship - - $38, 500
    2016 Invitation Invited Speaker: International Conference on Cancer Immunology and Immunotherapy - - -
    2016 Fellowship Endeavour Research Fellowship (unable to accept) - - 23 000
    2013 Award Dean’s Commendation for Doctoral Thesis Excellence - - -
    2011 Award HSANZ Non-Member Travel Grant - - 1000
    2010 Award HSANZ Non-Member Travel Grant - - 1500
    2010 Award New Scientist Award for Science and Technology in Society - - 1000
    2009 Scholarship Leukaemia Foundation of Australia PhD Scholarship - - 157 500
    2009 Scholarship Dawes Top-up Scholarship - - 17 500
    2009 Scholarship Baillieu Supplementary Research Scholarship - - 30 000
    2009 Scholarship NHMRC Biomedical Postgraduate Scholarship (unable to accept) - - 65 598
    2009 Scholarship Australian Postgraduate Award (unable to accept) - - 61 281
    2008 Award HSANZ Non-Member Travel Grant - - 1000
    2006 Award Australasian Society for HIV Medicine Junior Researcher Award - - -
    2006 Scholarship Royal Adelaide Hospital Research Committee Honours Scholarship - - 5000
    2005 Scholarship Molecular Plant Breeding Cooperative Research Centre Summer Scholarship - - 1500
    2004 Honour Admittance to the Golden Key International Honour Society - - -
  • Postgraduate Training

    Date Title Institution Country
    2016 - 2017 Fulbright Post-doctoral Research Scholarship St. Jude Children's Research Hospital United States
  • Research Interests

Date: June 2023 - June 2026

Project Name: “Modelling co-occurring mutations in T-ALL to enhance treatment options and maximise the power of next generation sequencing”

Chief Investigator A: Laura Eadie

Funding Body: Cancer Council South Australia Beat Cancer Project

Amount: $599,610

 

Date: January 2023 - December 2024

Project Name: “Modelling co-occurring mutations in T-ALL to enhance treatment options and maximise the power of next generation sequencing”

Chief Investigator A: Laura Eadie

Funding Body: SAHMRI Early and Mid-Career Researcher Seed Funding Grant

Amount: $30,000

 

Date: December 2022

Chief Investigator A: Laura Eadie

Funding Body: International Thermo Fisher Scientific Cancer Research Grant

Amount: in kind funding, ~$25,000

 

Date: January 2021 -  December 2024

Project Name: "Adolescents with Acute Lymphoblastic Leukaemia: Focussing on the gut microbiota, its role in therapeutic response and potential as an effective adjunct therapeutic in this High-Risk group"

Chief Investigator G: Laura Eadie

Funding Body: MRFF – Emerging Priorities and Consumer Driven Research Initiative Childhood Cancer Research

Amount: $1,292,871

 

Date: January 2019 - June 2023

Project Name: “Preclinical modelling of T-cell Acute Lymphoblastic Leukaemia – defining targeted therapies and preventing treatment resistance”

Chief Investigator A: Laura Eadie

Funding Body: Peter Nelson Leukaemia Research Fellowship Fund

Amount: $659,970

 

Date: unable to accept due to duplicate project funding

Project Name: “Preclinical modelling of T-cell Acute Lymphoblastic Leukaemia – defining targeted therapies and preventing treatment resistance”

Chief Investigator A: Laura Eadie

Funding Body: Cancer Council South Australia Beat Cancer Project

Amount: $599,971

 

Date: January 2019 - December 2020

Project Name: “Acute Lymphoblastic Leukaemia: Understanding the factors that determine response to new immune-based therapies”

Chief Investigator A: Deborah White

Associate Investigator: Laura Eadie

Funding Body: Tour de Cure

Amount: $100, 000

 

Date: January 2017 - December 2018

Project Name: “Using in vivo modelling to investigate therapeutic approaches to reverse/prevent disease resistance in children with high-risk Ph-like B-ALL and T-ALL treated with targeted therapies”

Application Number: 171412

Chief Investigator A: Laura Eadie

Associate Investigator: Deborah White

Funding Body: Channel 7 Children’s Research Foundation

Amount: $75, 000

Date: 2023 onwards

Adelaide University Lecturer

BIOCHEMISTRY III: Cancer, Stem Cells and Development III

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2023 Principal Supervisor Modelling co-occurring mutations in T-cell Acute Lymphoblastic Leukaemia to enhance treatment options and maximise the power of next generation sequencing Doctor of Philosophy Doctorate Full Time Mr Maxim Jon Buckley
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2022 Co-Supervisor Characterising KMT2A and MLLT10 Rearranged Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Miss Michelle Olivia Forgione
    2017 - 2021 Co-Supervisor Characterising the novel MYB-TYK2 fusion gene in high-risk acute lymphoblastic leukaemia: oncogenic potential, effective therapeutic strategies and In vitro modelling of drug resistance mechanisms Doctor of Philosophy Doctorate Full Time Miss Paniz Tavakoli Shirazi
    2015 - 2019 Co-Supervisor Multiple Molecular Mechanisms Contribute Towards In Vitro Resistance to Tyrosine Kinase Inhibitors In Chronic Myeloid Leukaemia Doctor of Philosophy Doctorate Full Time Mr Benjamin Chia Sing Leow
  • Other Supervision Activities

    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2020 - 2020 Principal Supervisor Investigation of oncogenic fusion genes in leukaemia and evaluation of the efficacy of ABL001 South Australian Health & Medical Research Institute - Honours Full Time Elias Lagonik
    2018 - ongoing Principal Supervisor Investigating the efficacy of novel and combination therapies in Ph-like ALL South Australian Health & Medical Research Institute - Honours Full Time Caitlin Schutz
    2014 - 2014 Co-Supervisor The effect of the T315I mutation on treatment failure in Chronic Myeloid Leukemia: a mere case of drug binding efficiency? South Australian Health & Medical Research Institute HONOURS DEGREE of BACHELOR OF HEALTH SCIENCES Honours Full Time Benjamin Leow
  • Mentoring

    Date Topic Location Name
    2020 - 2020 Careers Mentoring University of Adelaide Hannah Bonham
    2020 - 2020 Careers Mentoring University of Adelaide Mogana Reckdharajkumar
  • Committee Memberships

    Date Role Committee Institution Country
    2020 - 2021 Representative Australian Society for Medical Research SA Committee Australian Society for Medical Research Australia
    2019 - 2019 Treasurer Australian Society for Medical Research SA Committee Australian Society for Medical Research Australia
  • Memberships

    Date Role Membership Country
    2017 - ongoing Member National Postdoctoral Association United States
    2016 - ongoing Member Australian Society for Medical Research (ASMR) Australia
    2015 - 2016 Member YWCA -
    2006 - 2007 Member Australasian Society for HIV Medicine (ASHM) Australia
  • Presentation

    Date Topic Presented at Institution Country
    2019 - 2019 The Secret Life of a Scientist TEDxFulbright, Adelaide 2019 South Australian Health & Medical Research Institute Australia

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