ARC Senior Research Associate
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Kylie Dunning leads the Reproductive Success team within the Robinson Research Institute and the Australian Research Council (ARC) Centre of Excellence for Nanoscale BioPhotonics (CNBP).
Kylie is a reproductive biologist who aspires to use safe, cutting-edge, light-based technologies (also referred to as photonics) to better understand the biology that underpins successful development of the oocyte (egg) and early embryo. With one-in-six Australian couples struggling to start a family without medical intervention, Kylie is committed turning her laboratory discoveries into impact for these couples, engaging early and often with clinical experts to address the greatest clinical challenges.
With a focus on how oocytes (eggs) and embryos create energy, Kylie pioneered the paradigm-shifting research describing the requirement for lipid metabolism by the oocyte and early embryo.
With a drive to see outcomes for patients, Kylie is now using this knowledge and expertise with cutting-edge imaging and diagnostic technologies, to deliver the next generation of tools for the fertility clinic, and agriculture industry. She is leading the way in the development of safe, non-invasive diagnostic technologies that will change the way fertility specialists and embryologists select the best eggs and embryos, which will ultimately improve the experience for all couples seeking fertility care.
See more here:
ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP): http://www.cnbp.org.au
In our team we use safe, cutting-edge, light-based technologies (also referred to as photonics) to better understand the biology that underpins successful development of the oocyte (egg) and early embryo. With one-in-six Australian couples struggling to start a family without medical intervention, we are committed turning our laboratory discoveries into impact for these couples, engaging early and often with clinical experts to address the greatest clinical challenges.
We have a culturally and gender diverse team who are supportive and encouraging of each other. Our team members are Carl Campugan (research assistant), Annie Whitty (part-time research assistant) and postgraduate students: Megan Lim, Cheow (Tiffany) Tan, Suliman Yagoub, Darren Chow, Avi Saini and Hanna McLennan.
Research Project 1
Title: Biophotonic approaches to understanding preimplantation embryo development
Research Project 2
Title: Novel optical assessments of embryo development: can we pick the best embryo?
Project description: Increasingly, people are delaying starting a family until later in life. The expectation of conceiving children is often disrupted by infertility (1 in 6 Australian couples). Such a diagnosis can lead to reduced productivity, financial hardship, relationship breakdown and mental illness. Infertility is typically addressed by in vitro fertilization (IVF). Whilst IVF has seen major advancements, it still faces numerous challenges, most notably low success rates: only 18% of Australian and New Zealand initiated IVF cycles deliver a live birth. One of the reasons for the low success rate is the inability to select the healthiest embryo. In this project you will utilise cutting edge microscopy techniques combined with post-imaging assessments to better understand the pre-implantation embryo development period. You will be comparing normal healthy embryos with poor quality embryos: those which fail to complete the preimplantation period or lead to implantation failure or pregnancy loss. Our research is clinically relevant, and we are passionate about translating outcomes into the human IVF clinic and in agriculture. Don’t hesitate to contact us to discuss further.
Projects available for: Third Year / Honours / HDR
Location: Helen Mayo Building
Research project start: Semester 1 and 2
Special requirements: N/A
Date Position Institution name 2020 Chief Investigator ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) 2020 - 2022 The Hospital Research Foundation Fellow The University of Adelaide 2017 ARC Senior Research Associate University of Adelaide, Adelaide 2012 - 2016 ARC DECRA Fellow The University of Adelaide 2007 - 2011 NHMRC Research Associate University of Adelaide, Adelaide 2002 - 2003 Research Assistant Women's and Children's Hospital, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2019 Award Newcastle Reproduction Emerging Research Leader Award Society for Reproductive Biology Australia — 2012 Award Most Outstanding Early Career Researcher Discipline of Obstetrics and Gynaecology, The University of Adelaide — $3000 2010 Award First Place, Trainee Research Award Society for the Study of Reproduction United States — 2010 Award First place, Young Investigator Award Women's and Children's Hospital Australia $10,000 2010 Award Lalor Foundation Merit Award Lalor Foundation, Society for the Study of Reproduction United States — 2007 Award Robert Seamark Postgraduate Award University of Adelaide Australia — 2007 Award National Research Initiative (NRI) Merit Award United States Department of Agriculture, CSREES United States —
Language Competency English Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2008 University of Adelaide, Adelaide Australia Doctor of Philosophy 2002 University of Adelaide, Adelaide Australia Bachelor of Science (Honours) 2001 University of Adelaide, Adelaide Australia Bachelor of Science
Year Citation 2019 Findlay, J., Dunning, K., Gilchrist, R., Hutt, K., Russell, D., & Walters, K. (2019). Follicle Selection in Mammalian Ovaries. In P. Leung, & E. Adashi (Eds.), The Ovary (3 ed., pp. 3-21). United Kingdom: Academic Press.
Year Citation 2019 Dunning, K. R., Campugan, C., Tan, C., Mahbub, S., Goldys, E., & Thompson, J. (2019). Hyperspectral imaging of the early embryo: can it detect chromosome abnormalities and predict IVF success?. In Label-free Biomedical Imaging and Sensing (LBIS) Vol. 10890:108900I. San Francisco, US. 2017 Dunning, K., & Robker, R. (2017). The role of L-carnitine during oocyte in vitro maturation: essential co-factor?. In Animal Reproduction Vol. 14 (pp. 469-475). Cabo de Santo Agostinho, BRAZIL: Brazilian College of Animal Reproduction.
DOI Scopus2 WoS2
2011 Akison, L. K., Alvino, E. R., Dunning, K. R., Robker, R. L., & Russell, D. L. (2011). Migratory, Invasive and Adhesive Phenotypes Are Transiently Induced in the Cumulus Oocyte Complex at Ovulation.. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION. 2011 Russell, D. L., Matson, L. N., Dunning, K. R., Thompson, J. G., Robker, R. L., & Gilchrist, R. B. (2011). Patterning the Response to Oocyte Signals in Ovarian Follicle Morphogenesis.. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION. 2010 Yang, X., Wu, L., Dunning, K., Norman, R., Liang, X., & Robker, R. (2010). OBESITY ON INCREASES LIPID DROPLETS AND LIPOTOXICITY RESPONSES IN THE PERIOVULATORY CUMULUS-OOCYTECOMPLEX.. In FERTILITY AND STERILITY Vol. 94 (pp. S138-S139). Denver, CO: ELSEVIER SCIENCE INC.
2010 Wu, L. L., Dunning, K. R., Yang, X., Russell, D. L., Norman, R. J., & Robker, R. L. (2010). Oocytes Exhibit Lipid Accumulation, Endoplasmic Reticulum Stress, Mitochondrial Dysfunction, and Apoptosis in Response to High Fat Diet. In BIOLOGY OF REPRODUCTION (pp. 91). Milwaukee, WI: SOC STUDY REPRODUCTION.
2010 Dunning, K. R., Cashman, K., Russell, D. L., Thompson, J., Norman, R., & Robker, R. L. (2010). Increased Beta-Oxidation, ATP Levels, and Improved Oocyte Developmental Competence in Response to L-Carnitine. In BIOLOGY OF REPRODUCTION (pp. 84). Milwaukee, WI: SOC STUDY REPRODUCTION. 2009 Dunning, K. R., Cashman, K., Russell, D. L., Norman, R. N., & Robker, R. L. (2009). The Role of Beta-Oxidation During Oocyte Maturation and Embryo Development.. In BIOLOGY OF REPRODUCTION (pp. 54). Pittsburgh, PA: SOC STUDY REPRODUCTION. 2008 Dunning, K. R. (2008). Normal follicle growth and maturation in a three-dimensional in vitro culture system: follicular environment manipulation and assessment of oocyte outcomes.. In Reproduction, Fertility and Development Vol. 20 (pp. 108). Australia: CSIRO Publishing. 2007 Dunning, K., Lane, M., Brown, H., Yeo, C., Thompson, J., Robker, R., & Russell, D. (2007). Altered cumulus oocyte matrix following in vitro maturation of oocytes.. In BIOLOGY OF REPRODUCTION Vol. 77 (pp. 199). San Antonio, TX: SOC STUDY REPRODUCTION.
2006 Russell, D. L., Brown, H. M., Dunning, K. R., Pritchard, M. A., & Robker, R. L. (2006). Ovarian folliculogenesis and lymphangiogenesis are dependent on ECM remodelling by the protease ADAMTS-1.. In BIOLOGY OF REPRODUCTION (pp. 109). Univ Nebraska Med Ctr, Omaha, NE: SOC STUDY REPRODUCTION. 2005 Dunning, K., Yeo, C., & Russell, D. (2005). Altered matrix composition of cumulus oocyte complexes following in vitro maturation. In Reproduction Fertility and Development Vol. 17 (pp. 90). C S I R O Publishing.
Year Citation 2012 Sutton-McDowall, M., Feil, D., Robker, R., Thompson, J., & Dunning, K. (2012). UTILISATION OF ENDOGENOUS FATTY ACID STORES FOR ENERGY PRODUCTION IN BOVINE PRE-IMPLANTATION EMBRYOS. Poster session presented at the meeting of REPRODUCTION FERTILITY AND DEVELOPMENT. CSIRO PUBLISHING.
2018 Vevo 3100 ultrasound biomicroscope for the Adelaide Biomed city precinct. Ian Potter Foundation Research Grant. Gatford K, Care A, Di Bartolo B, Robertson S, Roberts C, Thompson J, Robker R, Russell D, Hull M, Diener K, Schjenken J, Zhang B, Dunning K, Reynolds P, Bursill C, Tan J, Nicholls S, Verjans J, O'Hare Doig R, Bonder C, Moore E, Howarth G, Ricciardelli C, Lokman N, Mashtoub S, Corbett M ($ 360,000)
2017 Robinson Research Institute Engaging Opportunities Grant The story telling and science of pregnancy loss. CIA H. Brown CIB K Dunning CIC C Roberts ($18,000)
2017 SRB Early Career Researcher Collaborative Research Award ($1500)
2017Robinson Research Institute Career Development Fellowship. CIA: K. Dunning, ($60,000)
2015 Robinson Research Institute Innovation Seed Funding Program. CIA: H. Brown, CIB: M. Nottle, CIC: K. Dunning, CID: K. Gatford. Preventing and Alleviating Infertility: Enabling the best start in life ($25,000)
2012-2017 Discovery Early Career Researcher Award (DECRA). Biomimetic systems for species preservation and fertility restoration ($375,000). CI K. Dunning Grant ID: DE120100304
2012 Channel 7 Children’s Foundation Research Grant [state-wide], CIA: L. Wu, CIB: K. Dunning, CIC: R. Robker, CID: R. Norman.”The impact of lipotoxicity in the ovaries and oocytes of obese women on embryo health” ($48,000)
2011 WCH Foundation Research Project Grant, CIA K. Dunning CIB R. Robker, CIC L. Hull “Modulating Lipid Metabolism to Improve the Growth of Follicles and Oocytes in vitro” ($50,000)
2011 Channel 7 Children’s Foundation Research Grant [state-wide], CIA: K. Dunning CIB: R Robker, Grant ID 11410, $35,000
2009 The Robinson Institute Early Career Research Grant, University of Adelaide ($10,000)
2014-2017 Lecturer, Research Projects in Reproductive Health, University of Adelaide
2015 Lecturer, Human Reproductive Health III, University of Adelaide
2010-2015 Lecturer, Honours Program, School of Paediatrics & Reproductive Health; University of Adelaide
2006-2007 Tutor, Bachelor of Surgery (MBBS) students, University of Adelaide
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor Chromosomal Abnormalities in the Female Gamete: Detection, Implications and Environmental Susceptibility Doctor of Philosophy Doctorate Full Time Mr Darren Jin Xiang Chow 2018 Co-Supervisor Towards Automation of IVF Doctor of Philosophy Doctorate Full Time Mr Suliman Hassan Suliman Yagoub 2017 Co-Supervisor Functional Role of Haemoglobin in the Pre-Implantation Embryo Doctor of Philosophy Doctorate Full Time Ms Megan Lim 2017 Co-Supervisor Can hyperspectral microscopy detect metabolic variance in the oocyte and pre-implantation embryo? Doctor of Philosophy Doctorate Full Time Miss Cheow Yuen Tan 2017 Co-Supervisor Non-reproductive uses of Zonae Pellucida Master of Philosophy (Medical Science) Master Full Time Avishkar Saini
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