Cheow Yuen Tan

NHMRC Grant-Funded Researcher A

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

My Research
Career
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Dr Tiffany Tan was awarded her PhD in 2022 for the innovative use of optical imaging to detect metabolic signatures associated with oocyte and embryo quality (mouse model).

Dr Tiffany is now an early career researcher in the Reproductive Success Group within the Robinson Research Institute, the Institute for Photonics and Advanced Sensing, and the School of Biomedicine, led by Dr. Kylie Dunning.

Tiffany's research focuses on using non-invasive light-based technologies to better understand the biology underpinning healthy oocyte (egg) and early embryo. Expanding from her PhD work, she is now using her expertise to build on interdisciplinary research, taking light-based technologies to diagnose embryo health and applying this to agriculturally important species.

Research topic: Non-invasive optical imaging techniques to measure changes in cellular metabolism to predict oocyte and embryo health.

Interest: Non-invasive optical imaging approach; autofluorescence of endogenous fluorophores; oocyte and embryo quality; metabolism

Appointments

Date	Position	Institution name
2022 - ongoing	Postdoctoral Researcher	University of Adelaide
2020 - 2022	Quality Coordinator	University of Adelaide, IVF Vet Solutions
2018 - 2020	Research Assistant	University of Adelaide
2015 - 2017	Research Assistant	University of Adelaide

Awards and Achievements

Date Type Title Institution Name Country Amount

2023 Award The Ross Wishart Memorial Award The Australian Society for Medical Research Australia 1000

Date	Type	Title	Institution Name	Country	Amount
2023	Award	The Ross Wishart Memorial Award	The Australian Society for Medical Research	Australia	1000

Language Competencies

Language	Competency
Chinese (Mandarin)	Can read, write, speak, understand spoken and peer review
English	Can read, write, speak, understand spoken and peer review
Malay	Can read, write, speak and understand spoken

Education

Date	Institution name	Country	Title
2017 - 2022	University of Adelaide	Australia	PhD
2014 - 2015	University of Adelaide	Australia	Bachelor of Health Science (Honours)
2011 - 2014	University of Adelaide	Australia	Bachelor of Biomedical Science (Microbiology and Immunology; Biochemistry)

Research Interests

Biophotonics Cell Metabolism Microscopy Reproductive Biology

Journals

Year	Citation
2023	Dwapanyin, G. O., Chow, D. J. X., Tan, T. C. Y., Dubost, N. S., Morizet, J. M., Dunning, K. R., & Dholakia, K. (2023). Investigation of refractive index dynamics during in vitro embryo development using off-axis digital holographic microscopy. Biomedical Optics Express, 14(7), 3327-3342. DOI Scopus5 Europe PMC5
2022	Yagoub, S. H., Lim, M., Tan, T. C. Y., Chow, D. J. X., Dholakia, K., Gibson, B. C., . . . Dunning, K. R. (2022). Correction to: Vitrification within a nanoliter volume: oocyte and embryo cryopreservation within a 3D photopolymerized device.. J Assist Reprod Genet, 39(10), 2435. DOI
2022	Tan, T. C. Y., & Dunning, K. R. (2022). Non-invasive assessment of oocyte developmental competence. Reproduction Fertility and Development, 35(1-2), 39-50. DOI Scopus9 WoS2 Europe PMC5
2022	Campugan, C. A., Lim, M., Chow, D. J. X., Tan, T. C. Y., Li, T., Saini, A. A., . . . Dunning, K. R. (2022). The effect of discrete wavelengths of visible light on the developing murine embryo. Journal of Assisted Reproduction and Genetics, 39(8), 1825-1837. DOI Scopus7 WoS3 Europe PMC3
2022	Tan, T. C. Y., Brown, H. M., Thompson, J. G., Mustafa, S., & Dunning, K. R. (2022). Optical imaging detects metabolic signatures associated with oocyte quality. Biology of Reproduction, 107(4), 1014-1025. DOI Scopus9 WoS3 Europe PMC4
2022	Yagoub, S. H., Lim, M., Tan, T. C. Y., Chow, D. J. X., Dholakia, K., Gibson, B. C., . . . Dunning, K. R. (2022). Vitrification within a nanoliter volume: oocyte and embryo cryopreservation within a 3D photopolymerized device. Journal of Assisted Reproduction and Genetics, 39(9), 1997-2014. DOI Scopus4 WoS2 Europe PMC3
2022	Tan, C., Mahbub, S., Campbell, J., Habibalahi, A., Campugan, C., Rose, R., . . . Dunning, K. (2022). Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo. Human Reproduction, 37(1), 14-29. DOI Scopus24 WoS15 Europe PMC14
2021	Santos Monteiro, C. A., Chow, D. J. X., Leal, G. R., Tan, C. Y., Reis Ferreira, A. M., Thompson, J. G., & Dunning, K. R. (2021). Optical imaging of cleavage stage bovine embryos using hyperspectral and confocal approaches reveals metabolic differences between on-time and fast-developing embryos. Theriogenology, 159, 60-68. DOI Scopus19 WoS12 Europe PMC8
2019	Frank, L. A., Rose, R. D., Anastasi, M. R., Tan, C., Barry, M. F., Thompson, J. G., & Brown, H. M. (2019). Artificial blastocyst collapse prior to vitrification significantly improves Na+/K+-ATPase-dependent post-warming blastocoel re-expansion kinetics without inducing endoplasmic reticulum stress gene expression in the mouse. Reproduction, Fertility and Development, 31(2), 294-305. DOI Scopus7 WoS4 Europe PMC3
2018	Shathili, A. M., Brown, H. M., Everest-Dass, A. V., Tan, T. C., Parker, L. M., Thompson, J. G., & Packer, N. H. (2018). The effect of streptozotocin-induced hyperglycemia on N-and O-linked protein glycosylation in mouse ovary. Glycobiology, 28(11), 832-840. DOI Scopus13 WoS10 Europe PMC4
2018	Brown, H., Green, E., Tan, T., Gonzalez, M., Rumbold, A., Hull, M., . . . Thompson, J. (2018). Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy. Scientific reports, 8(1), 2114-1-2114-13. DOI Scopus32 WoS23 Europe PMC15
2016	Tan, T., Ritter, L., Whitty, A., Fernandez, R., Moran, L., Robertson, S., . . . Brown, H. (2016). Gray level co-occurrence matrices (GLCM) to assess microstructural and textural changes in pre-implantation embryos. Molecular Reproduction and Development, 83(8), 701-713. DOI Scopus28 WoS23 Europe PMC6
2015	Brown, H. M., Tan, C. Y. T., & Thompson, J. (2015). Metaboloepigenetics: providing alternate hypotheses for regulation of gene expression in the early embryo. Animal Reproduction, 3, 437-443.

Conference Papers

Year	Citation
2023	Dwapanyin, G. O., Chow, D. J. X., Tan, T. C. Y., Dubost, N. S., Morizet, J. M., Dunning, K. R., & Dholakia, K. (2023). Digital holographic microscopic assessment of embryo quality. In Frontiers in Optics: Proceedings Frontiers in Optics + Laser Science 2023, FiO, LS 2023 Vol. 60 (pp. FM1E.2). Online: Optical Society of America. DOI
2019	Dunning, K. R., Campugan, C., Tan, C., Mahbub, S., Goldys, E., Thompson, J., . . . Mustafa, S. (2019). Hyperspectral imaging of the early embryo: can it detect chromosome abnormalities and predict IVF success?. In Label-free Biomedical Imaging and Sensing (LBIS) Vol. 10890:108900I (pp. 1-3). online: SPIE. DOI Scopus2 WoS1
2015	Brown, H., Tan, T., & Thompson, J. (2015). Metaboloepigenetics: providing alternative hypotheses for regulation of gene expression in the early embryo. In Animal Reproduction Vol. 12 (pp. 437-443). Brazil: Brazilian College of Animal Reproduction. WoS3

Conference Items

Year	Citation
2021	Tan, C. Y., Mahbub, S. B., Campugan, C. A., Campbell, J., Habibalahi, A., Chow, D. J. X., . . . Dunning, K. R. (2021). Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo. Poster session presented at the meeting of Abstracts of the 37th Annual Meeting of the European Society of Human Reproduction and Embryology, as published in Human Reproduction. virtual online: Oxford University Press (OUP). DOI

Year

Citation

2021

Tan, C. Y., Mahbub, S. B., Campugan, C. A., Campbell, J., Habibalahi, A., Chow, D. J. X., . . . Dunning, K. R. (2021). Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo. Poster session presented at the meeting of Abstracts of the 37th Annual Meeting of the European Society of Human Reproduction and Embryology, as published in Human Reproduction. virtual online: Oxford University Press (OUP).
DOI

Preprint

Year Citation

2023 Li, T., Li, S., Chow, D. J. X., Rose, R., Tan, T. C. Y., & Dunning, K. (2023). Impact of repeated cryopreservation on embryo health and implantation potential.
DOI

Year	Citation
2023	Li, T., Li, S., Chow, D. J. X., Rose, R., Tan, T. C. Y., & Dunning, K. (2023). Impact of repeated cryopreservation on embryo health and implantation potential. DOI

SCHOLARSHIP AND ACADEMIC AWARDS

2023 Society for the Study of Reproduction - International Trainee Travel Award (AUD 1500)

2022 RRI Career Development Award (AUD 1000)

2022 Adelaide Medical School Publication Awards (AUD 100)

2021 Faculty of Health and Medical Science Publication Excellence Award (AUD 5000)

2021 European Society of Human Reproduction and Embryology (ESHRE) Basic Science Award for

Oral Presentation (AUD 3300)

2020 Society of Reproductive Biology (SRB) ART Lab Solutions Investigator Award (AUD 500)

2019 Society of Reproductive Biology (SRB) Travel Award (AUD 200)

2019 Robinson Research Institute 2019 Travel Grants Program (Round 2) (AUD 600)

2019 ARC Centre for Nanoscale and Biophotonics Student Travel Award (UNSW – Collaboration Work) (AUD 5000)

2018 Best Poster - Annual Conference of ARC Centre for Nanoscale and Biophotonics

2018 ARC Centre for Nanoscale and Biophotonics Student Travel Award (UNSW – Collaboration Work) (AUD 2000)

2018 ARC Centre for Nanoscale and Biophotonics Student Travel Award (Publication Masterclass) (AUD 1000)

2017-2022 Research Training Program Scholarship (Full time PHD Candidate) (AUD 24 000 per annum)

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2023	Co-Supervisor	Does cryopreservation induce aneuploidy in embryos?	Doctor of Philosophy	Doctorate	Full Time	Ms Tong Li

Other Supervision Activities

Date	Role	Research Topic	Location	Program	Supervision Type	Student Load	Student Name
2023 - ongoing	Co-Supervisor	Impact of discrete wavelengths of light on mouse preimplantation embryo development	University of Adelaide	-	Honours	Full Time	Shan Li
2023 - ongoing	Co-Supervisor	Investigating the role of IVF procedures and genetics on embryo metabolism	University of Adelaide	-	Honours	Full Time	Wenyu Li
2022 - 2023	Co-Supervisor	Impact of repeated cryopreservation on embryo health and implantation potential	University of Adelaide	BHMS Honours (Medical Subplan)	Honours	Full Time	Tong Li

Committee Memberships

Date	Role	Committee	Institution	Country
2023 - ongoing	Member	The Science Network Committee	Institute for Photonics and Advanced Sensing	Australia
2022 - ongoing	Treasurer	The Australian Society for Medical Research	The Australian Society for Medical Research	Australia

Memberships

Date Role Membership Country

2023 - ongoing Member Society for the Study of Reproduction United States

2018 - ongoing Member The Society for Reproductive Biology Australia

Date	Role	Membership	Country
2023 - ongoing	Member	Society for the Study of Reproduction	United States
2018 - ongoing	Member	The Society for Reproductive Biology	Australia

Position: NHMRC Grant-Funded Researcher A
Email: cheowyuen.tan@adelaide.edu.au
Campus: North Terrace
Building: Helen Mayo South
Org Unit: Medical Sciences

Cheow Yuen Tan

Appointments

Awards and Achievements

Language Competencies

Education

Research Interests

Journals

Conference Papers

Conference Items

Preprint

Current Higher Degree by Research Supervision (University of Adelaide)

Other Supervision Activities

Committee Memberships

Memberships

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