Katja Hummitzsch

Dr Katja Hummitzsch

Postdoctoral Research Associate

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr. Katja Hummitzsch is a Senior NHMRC Research Associate in the Ovarian Developmental Group of Prof. Raymond Rodgers. Her current work focuses on novel aspects of ovarian development [characterisation of a fetal precursor cell (GREL cell), the role of stroma in the development of the ovarian surface epithelium], and the fetal origins of polycystic ovary syndrome, as well as the relationship between steroidogenesis, oxidative stress and antioxidants in bovine granulosa cells. 

Her research findings have led to a new model of how the mammalian ovary develops and to the identification of a novel ovarian precursor cell for granulosa and surface epithelial cells, called Gonadal Ridge Epithelial-like (GREL) cell. YouTube video showing the formation of the ovary as a comic:

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  • Journals

    Year Citation
    2021 Tong, K. K. H., Hanif, M., Movassaghi, S., Sullivan, M. P., Lovett, J. H., Hummitzsch, K., . . . Hartinger, C. G. (2021). Triazolyl-Functionalized N-Heterocyclic Carbene Half-Sandwich Compounds: Coordination Mode, Reactivity and in vitro Anticancer Activity. ChemMedChem, 11 pages.
    DOI
    2020 Hartanti, M. D., Hummitzsch, K., Bonner, W. M., Bastian, N. A., Irving-Rodgers, H. F., & Rodgers, R. J. (2020). Formation of the bovine ovarian surface epithelium during fetal development. Journal of Histochemistry and Cytochemistry, 68(2), 113-126.
    DOI Scopus2 WoS2 Europe PMC1
    2020 Copping, K. J., Hernandez-Medrano, J., Hoare, A., Hummitzsch, K., McMillen, I. C., Morrison, J., . . . Perry, V. (2020). Maternal periconceptional and first trimester protein restriction in beef heifers: effects on placental parameters and fetal and neonatal calf development. Reproduction, Fertility and Development, 32(5), 495-507.
    DOI Scopus7 WoS7 Europe PMC2
    2020 Hartanti, M. D., Rosario, R., Hummitzsch, K., Bastian, N. A., Hatzirodos, N., Bonner, W. M., . . . Rodgers, R. J. (2020). Could perturbed fetal development of the ovary contribute to the development of polycystic ovary syndrome in later life?. PloS one, 15(2), e0229351-1-e0229351-24.
    DOI Scopus5 WoS3 Europe PMC2
    2020 Truong, D., Sullivan, M. P., Tong, K. K. H., Steel, T. R., Prause, A., Lovett, J. H., . . . Hartinger, C. G. (2020). Potent inhibition of thioredoxin reductase by the Rh derivatives of anticancer M(arene/Cp*)(NHC)Cl₂ complexes. Inorganic Chemistry, 59(5), 3281-3289.
    DOI Scopus15 WoS15 Europe PMC1
    2020 Liu, M., Hummitzsch, K., Hartanti, M. D., Rosario, R., Bastian, N. A., Hatzirodos, N., . . . Rodgers, R. J. (2020). Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries. Biology of Reproduction, 103(4), 840-853.
    DOI
    2020 Tong, K. K. H., Hanif, M., Lovett, J. H., Hummitzsch, K., Harris, H. H., Söhnel, T., . . . Hartinger, C. G. (2020). Thiourea-Derived Chelating Ligands and Their Organometallic Compounds: Investigations into Their Anticancer Activity.. Molecules, 25(16), 22 pages.
    DOI Scopus4 WoS5 Europe PMC2
    2019 Hartanti, M., Hummitzsch, K., Irving-Rodgers, H., Bonner, W., Copping, K., Anderson, R., . . . Rodgers, R. (2019). Morphometric and gene expression analyses of stromal expansion during development of the bovine fetal ovary. Reproduction, Fertility and Development, 31(3), 482-495.
    DOI Scopus4 WoS3 Europe PMC2
    2019 Rodgers, R., Suturina, L., Lizneva, D., Davies, M., Hummitzsch, K., Irving-Rodgers, H., & Robertson, S. (2019). Is polycystic ovary syndrome a 20th Century phenomenon?. Medical Hypotheses, 124, 31-34.
    DOI Scopus6 WoS5 Europe PMC2
    2019 Hatzirodos, N., Hummitzsch, K., Irving-Rodgers, H. F., Breen, J., Perry, V. E. A., Anderson, R. A., & Rodgers, R. J. (2019). Transcript abundance of stromal and thecal cell related genes during bovine ovarian development. PLoS ONE, 14(3), e0213575-1-e0213575-16.
    DOI Scopus12 WoS12 Europe PMC9
    2019 Hummitzsch, K., Hatzirodos, N., Irving-Rodgers, H. F., Hartanti, M. D., Perry, V. E. A., Anderson, R. A., & Rodgers, R. J. (2019). Morphometric analyses and gene expression related to germ cells, gonadal ridge epithelial-like cells and granulosa cells during development of the bovine fetal ovary. PloS one, 14(3), 1-20.
    DOI Scopus7 WoS7 Europe PMC6
    2019 Hummitzsch, K., Hatzirodos, N., Macpherson, A. M., Schwartz, J., Rodgers, R. J., & Irving-Rodgers, H. F. (2019). Transcriptome analyses of ovarian stroma: Tunica albuginea, interstitium and Theca interna. Reproduction, 157(6), 545-565.
    DOI Scopus6 Europe PMC4
    2017 Hatzirodos, N., Glister, C., Hummitzsch, K., Irving-Rodgers, H., Knight, P., & Rodgers, R. (2017). Transcriptomal profiling of bovine ovarian granulosa and theca interna cells in primary culture in comparison with their in vivo counterparts. PLoS ONE, 12(3), e0173391-1-e0173391-17.
    DOI Scopus15 WoS14 Europe PMC8
    2016 Ceko, M., O'Leary, S., Harris, H., Hummitzsch, K., & Rodgers, R. (2016). Trace elements in ovaries: measurement and physiology. Biology of Reproduction, 94(4), 86-1-86-14.
    DOI Scopus13 WoS13 Europe PMC3
    2016 Bastian, N., Bayne, R., Hummitzsch, K., Hatzirodos, N., Bonner, W., Hartanti, M., . . . Rodgers, R. (2016). Regulation of fibrillins and modulators of TGFβ in fetal bovine and human ovaries. Reproduction, 152(2), 127-137.
    DOI Scopus8 WoS8 Europe PMC5
    2015 Ceko, M., Hummitzsch, K., Hatzirodos, N., Bonner, W., Aitken, J., Russell, D., . . . Harris, H. (2015). X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function. Metallomics, 7(1), 71-82.
    DOI Scopus29 WoS32 Europe PMC11
    2015 Ceko, M. J., Hummitzsch, K., Hatzirodos, N., Bonner, W. M., Aitken, J. B., Russell, D. L., . . . Harris, H. H. (2015). Erratum: X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function (Metallomics (2014) DOI:10.1039/c4mt00228h). Metallomics, 7(1), 188.
    DOI Scopus6 WoS3 Europe PMC2
    2015 Hummitzsch, K., Anderson, R., Wilhelm, D., Wu, J., Telfer, E., Russell, D., . . . Rodgers, R. (2015). Stem cells, progenitor cells, and lineage decisions in the ovary. Endocrine Reviews, 36(1), 65-91.
    DOI Scopus53 WoS52 Europe PMC35
    2015 Ceko, M., Hummitzsch, K., Hatzirodos, N., Bonner, W., James, S., Kirby, J., . . . Harris, H. (2015). Distribution and speciation of bromine in mammalian tissue and fluids by X-ray fluorescence imaging and X-ray absorption spectroscopy. Metallomics, 7(5), 756-765.
    DOI Scopus17 WoS15 Europe PMC6
    2015 Hatzirodos, N., Hummitzsch, K., Irving-Rodgers, H., & Rodgers, R. (2015). Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles. PLoS One, 10(3), e0119800-1-e0119800-13.
    DOI Scopus36 WoS34 Europe PMC23
    2015 Ceko, M., Hummitzsch, K., Hatzirodos, N., Rodgers, R., & Harris, H. (2015). Quantitative elemental analysis of bovine ovarian follicles using X-ray fluorescence imaging. Metallomics, 7(5), 828-836.
    DOI Scopus9 WoS9 Europe PMC4
    2015 Ceko, M., Hummitzsch, K., Bonner, W., Aitken, J., Spiers, K., Rodgers, R., & Harris, H. (2015). Localization of the trace elements iron, zinc and selenium in relation to anatomical structures in bovine ovaries by X-ray fluorescence imaging. Microscopy and Microanalysis, 21(3), 695-705.
    DOI Scopus11 WoS11 Europe PMC5
    2014 Ceko, M., Hummitzsch, K., Hatzirodos, N., Bonner, W., Aitken, J., Russell, D., . . . Harris, H. (2014). Correction: X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function.. Metallomics : integrated biometal science, 7(1), 188.
    DOI
    2014 Glister, C., Hatzirodos, N., Hummitzsch, K., Knight, P., & Rodgers, R. (2014). The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells. BMC Genomics, 15(1), 1-15.
    DOI Scopus22 WoS19 Europe PMC11
    2014 Hatzirodos, N., Irving-Rodgers, H., Hummitzsch, K., Harland, M., Morris, S., & Rodgers, R. (2014). Transcriptome profiling of granulosa cells of bovine ovarian follicles during growth from small to large antral sizes. BMC Genomics, 15(24), 1-19.
    DOI Scopus100 WoS94 Europe PMC59
    2014 Hatzirodos, N., Hummitzsch, K., Irving-Rodgers, H., Harland, M., Morris, S., & Rodgers, R. (2014). Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia. BMC Genomics, 15(40), 1-26.
    DOI Scopus77 WoS64 Europe PMC48
    2014 Irving-Rodgers, H., Choong, F., Hummitzsch, K., Parish, C., Rodgers, R., & Simeonovic, C. (2014). Pancreatic islet basement membrane loss and remodeling after mouse islet isolation and transplantation: impact for allograft rejection. Cell Transplantation, 23(1), 59-72.
    DOI Scopus43 WoS41 Europe PMC26
    2014 Hatzirodos, N., Irving-Rodgers, H., Hummitzsch, K., & Rodgers, R. (2014). Transcriptome profiling of the theca interna from bovine ovarian follicles during atresia. PLoS One, 9(6), e99706-1-e99706-14.
    DOI Scopus29 WoS25 Europe PMC17
    2014 Hatzirodos, N., Hummitzsch, K., Irving-Rodgers, H., & Rodgers, R. (2014). Transcriptome profiling of the theca interna in transition from small to large antral ovarian follicles. PLoS One, 9(5), e97489-1-e97489-10.
    DOI Scopus28 WoS24 Europe PMC17
    2013 Hummitzsch, K., Irving-Rodgers, H., Hatzirodos, N., Bonner, W., Sabatier, L., Reinhardt, D., . . . Rodgers, R. (2013). A new model of development of the mammalian ovary and follicles. PLoS One, 8(2), 1-16.
    DOI Scopus79 WoS72 Europe PMC33
    2012 Nguyen, T., Lee, S., Hatzirodos, N., Hummitzsch, K., Sullivan, T., Rodgers, R., & Irving-Rodgers, H. (2012). Spatial differences within the membrana granulosa in the expression of focimatrix and steroidogenic capacity. Molecular and Cellular Endocrinology, 363(1-2), 62-73.
    DOI Scopus10 WoS11 Europe PMC9
    2012 Hatzirodos, N., Nigro, J., Irving-Rodgers, H., Vashi, A., Hummitzsch, K., Caterson, B., . . . Rodgers, R. (2012). Glycomic analyses of ovarian follicles during development and atresia. Matrix Biology, 31(1), 45-56.
    DOI Scopus14 WoS14 Europe PMC11
    2011 Hatzirodos, N., Bayne, R., Irving-Rodgers, H., Hummitzsch, K., Sabatier, L., Lee, S., . . . Rodgers, R. (2011). Linkage of regulators of TGF-β activity in the fetal ovary to polycystic ovary syndrome. FASEB Journal, 25(7), 2256-2265.
    DOI Scopus62 WoS53 Europe PMC42
    2011 Ween, M., Hummitzsch, K., Rodgers, R., Oehler, M., & Ricciardelli, C. (2011). Versican induces a pro-metastatic ovarian cancer cell behavior which can be inhibited by small hyaluronan oligosaccharides. Clinical & Experimental Metastasis, 28(2), 113-125.
    DOI Scopus51 WoS52 Europe PMC38
    2010 Irving-Rodgers, H., Hummitzsch, K., Murdiyarso, L., Bonner, W., Sado, Y., Ninomiya, Y., . . . Rodgers, R. (2010). Dynamics of extracellular matrix in ovarian follicles and corpora lutea of mice. Cell and Tissue Research, 339(3), 613-624.
    DOI Scopus37 WoS35 Europe PMC27
    2009 Koch, D., Sakurai, M., Hummitzsch, K., Hermsdorf, T., Erdmann, S., Schwalbe, S., . . . Ricken, A. M. (2009). KIT variants in bovine ovarian cells and corpus luteum. Growth Factors, 27(2), 100-113.
    DOI Scopus9 WoS9 Europe PMC6
    2009 Serke, H., Vilser, C., Nowicki, M., Hmeidan, F., Blumenauer, V., Hummitzsch, K., . . . Spanel-Borowski, K. (2009). Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor. Autophagy, 5(7), 991-1003.
    DOI Scopus38 WoS38 Europe PMC30
    2009 Hummitzsch, K., Ricken, A. M., Kloß, D., Erdmann, S., Nowicki, M. S., Rothermel, A., . . . Spanel-Borowski, K. (2009). Spheroids of granulosa cells provide an in vitro model for programmed cell death coupled to steroidogenesis. Differentiation, 77(1), 60-69.
    DOI Scopus8 WoS8 Europe PMC5
    2008 Erdmann, S., Ricken, A., Hummitzsch, K., Merkwitz, C., Schliebe, N., Gaunitz, F., . . . Spanel-Borowski, K. (2008). Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures. European Journal of Cell Biology, 87(5), 311-323.
    DOI Scopus14 WoS13 Europe PMC12
    2007 Ricken, A., Traenkner, A., Merkwitz, C., Hummitzsch, K., Grosche, J., & Spanel-Borowski, K. (2007). The short prolactin receptor predominates in endothelial cells of micro- and macrovascular origin. Journal of Vascular Research, 44(1), 19-30.
    DOI Scopus21 WoS21 Europe PMC16
    2007 Erdmann, S., Ricken, A., Merkwitz, C., Struman, I., Castino, R., Hummitzsch, K., . . . Spanel-Borowski, K. (2007). The Expression of Prolactin and its Cathepsin D-mediated Cleavage in the bovine Corpus luteum vary with the Oestrous cycle. American Journal of Physiology-Endocrinology and Metabolism, 293(5), E1365-E1377.
    DOI Scopus29 WoS29 Europe PMC19
  • Book Chapters

    Year Citation
    2019 Hummitzsch, K., Irving-Rodgers, H., Schwartz, J., & Rodgers, R. J. (2019). Development of the Mammalian Ovary and Follicles. In P. Leung, & E. Adashi (Eds.), The Ovary (3 ed., pp. 71-82). United Kingdom: Academic press.
  • Conference Papers

    Year Citation
    2011 Irving-Rodgers, H., Hatzirodos, N., Hummitzsch, K., Lee, S., Bonner, W., Sabatier, L., . . . Rodgers, R. J. (2011). Expression of Fibrillins, Latent TGFbeta Binding Proteins and TGFbetas in the Bovine Fetal Ovary. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION.
    2009 Tsikolia, N., Hummitzsch, K., Sass, K., Spanel-Borowski, K., & Ricken, A. (2009). Fetal Leydig precursor cells are strongly positive for KIT. In REPRODUCTION IN DOMESTIC ANIMALS Vol. 44 (pp. 37-38). Leipzig, GERMANY: WILEY-BLACKWELL PUBLISHING, INC.
    2007 Erdmann, S., Ricken, A., Hummitzsch, K., & Spanel-Borowski, K. (2007). Increase in extracellular procathepsin D levels by cytokines: a possible mechanism to gain influence on endothelial cells?. In EUROPEAN JOURNAL OF CELL BIOLOGY Vol. 86 (pp. 47). Johann Wolfgang Goethe Univ Frankfurt, Frankfurt, GERMANY: ELSEVIER GMBH, URBAN & FISCHER VERLAG.
    2007 Hummitzsch, K., Ricken, A., Kloss, D., Erdmann, S., Rothermel, A., Robitzki, A., & Spanel-Borowski, K. (2007). Granulosa cell spheroids provide a better model for luteinization than monolayers. In EUROPEAN JOURNAL OF CELL BIOLOGY Vol. 86 (pp. 27). Johann Wolfgang Goethe Univ Frankfurt, Frankfurt, GERMANY: ELSEVIER GMBH, URBAN & FISCHER VERLAG.
Grants and Funding
2020

Robinson Research Institute Career Development Fellowship

CRE WHiRL Seed Grant and Project Support

Robinson Research Institute Building On Ideas Grant

$100,000

$13,250

$5,000

2013 Cook Medical Travel Award $5,000
2012

Robinson Institute Travel Grant

SRB Early Career Researcher Registration Subsidy

$900

$200

2011 Research Centre for Reproductive Health Travel Grant $500

 

Teaching
2016

3007MSC Histology for Bachelor of Medical Laboratory Science [accredited by the Australian Institute of Medical Scientists (AIMS) and the Institute of Biomedical Science (IBMS)], Griffith University, Gold Coast, Queensland; Lecture "Female Reproductive Tract" and Laboratory Demonstrating "H&E staining and tissue section evaluation"

2014 Research Project in Reproductive Health, The University of Adelaide, Lecture "Presenting research results – figures, tables & text"

 

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2021 Co-Supervisor Aneuploidy of oocytes Doctor of Philosophy Doctorate Full Time Mr Feng Tang
    2020 Co-Supervisor Meiotic Drive and Chromosome Segregation Doctor of Philosophy Doctorate Full Time Mr Feng Tang
    2019 Co-Supervisor Genetic and fetal origins of polycystic ovary syndrome Doctor of Philosophy Doctorate Full Time Ms Rafiatu Azumah
    2017 Co-Supervisor Studies of the Developing Fetal Ovary Doctor of Philosophy Doctorate Full Time Menghe Liu
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2014 - 2019 Co-Supervisor The Development of Bovine Fetal Ovary and Its Relationship with Reproductive Disease Doctor of Philosophy Doctorate Full Time Mrs Monica Dwi Hartanti
  • Other Supervision Activities

    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2014 - 2014 Co-Supervisor Fibrillin 3 and its regulation during fetal ovarian development The University of Adelaide Honours Nicole Anne Bastian
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  • Committee Memberships

    Date Role Committee Institution Country
    2019 - 2019 Member Organising Committee for New Frontiers for a Healthy Start to Life Conference Robinson Research Institute, The University of Adelaide Australia
  • Memberships

    Date Role Membership Country
    2021 - ongoing Member Healthy Development Adelaide Australia
    2020 - ongoing Member Reproductive Health Australia Australia
    2018 - ongoing Member Faculty of 1000 United Kingdom
    2014 - 2015 Member International Society for Developmental Origins of Health and Disease
    2012 - ongoing Member Society of Reproductive Biology
    2009 - 2010 Member Australian Society for Medical Research
  • Editorial Boards

    Date Role Editorial Board Name Institution Country
    2015 - ongoing Editor Frontiers in Endocrinology Frontiers Switzerland
  • Offices Held

    Date Office Name Institution Country
    2021 - 2021 Postgraduate Coordinator (AHMS Precinct) The University of Adelaide Australia
  • Review, Assessment, Editorial and Advice

    Date Title Type Institution Country
    2019 - ongoing Human Reproduction Peer Review N/A
    2019 - ongoing International Journal of Molecular Sciences Peer Review N/A
    2018 - ongoing Animal Reproductive Science Peer Review N/A
    2017 - 2017 Research Project Reviewer for Bachelor of Biomedical Sciences Thesis Review Griffith University
    2017 - ongoing Theriogenology Peer Review N/A
    2017 - ongoing Colloids and Surfaces B: Biointerfaces Peer Review N/A
    2017 - ongoing Reproductive Health Peer Review N/A
    2017 - ongoing Frontiers in Endocrinology, Section Genomic Endocrinology Peer Review N/A
    2016 - ongoing American Journal of Physiology – Cell Physiology Peer Review N/A
    2016 - ongoing Endocrinology Peer Review N/A
    2015 - ongoing Journal of Histochemistry and Cytochemistry Peer Review N/A
    2015 - ongoing Cell & Tissue Research Peer Review N/A
    2014 - ongoing BMC Developmental Biology Peer Review N/A
    2014 - 2014 Review of submitted abstracts for 9th International Ruminant Reproduction Symposium, Japan Conference Review N/A
    2014 - ongoing Honours Thesis Reviewer for Paediatrics and Reproductive Health Thesis Review The University of Adelaide
    2014 - ongoing Molecular Human Reproduction Peer Review N/A
    2012 - ongoing Reproduction, Fertility and Development Peer Review N/A
    2010 - ongoing Reproduction Peer Review N/A
    2010 - ongoing Molecular and Cellular Endocrinology Peer Review N/A
  • Position: Postdoctoral Research Associate
  • Phone: 83133371
  • Email: katja.hummitzsch@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 5
  • Room: WS5071.11
  • Org Unit: Women's and Children's Health

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