Higher Degree by Research Candidate
School of Biomedicine
Faculty of Health and Medical Sciences
I am a PhD candidate working on the pathophysiology of Polycystic Ovary Syndrome (PCOS) with focus on the genetic and fetal origins of the syndrome under the supervision of Prof. Raymond Rodgers.
Polycystic Ovary Syndrome (PCOS) is a complex syndrome which presents endocrine, metabolic and reproductive symptoms, affecting about 10% of women of reproductive age. However, the pathogenesis of PCOS is poorly understood hence diagnosis is usually delayed due to the numerous associated symptoms, and treatment is mainly based on management of presenting symptoms. Moreover, studies involving animals and women with the syndrome as well as their offspring have shown similar patterns that infer the possible fetal origin of PCOS. Thus, children born to women with PCOS have an increased risk of the syndrome compared to those not exposed. Interestingly, candidate genes associated with PCOS have been identified in human and bovine fetal ovaries, further confirming the genetic and fetal origins of the syndrome. Considering the strong similarities between human and bovine ovaries in morphology and physiology, gestational length and relative number of birth outcomes, my project seeks to define the upstream regulators and mechanisms associated with PCOS candidate genes using the bovine fetal ovaries.
Polycystic Ovary Syndrome (PCOS) is a complex syndrome affecting about 10% of women of reproductive age.
‘Polycystic ovary syndrome (PCOS) is a frustrating experience for women, often complex for managing clinicians and is a scientific challenge for researchers’ (Teede et al, 2010). The outcomes of genome wide association studies and candidate gene studies towards defining PCOS have, arguably, almost impact on the diagnosis and treatment of the syndrome. This could be attributed mainly to the divergence of PCOS studies, thus these studies have not collectively defined the molecular mechanisms involved in PCOS phenotypes observed. Currently, attempts to define the genetic and fetal origins have been become the focus of most research in PCOS. Also, the upstream mechanisms involved in expression of PCOS candidate genes have not been analysed in detail.
Awards and Achievements
Date Type Title Institution Name Country Amount 2021 Scholarship NHMRC CRE WHiRL PhD top-up scholarship The University of Adelaide Australia $6000 2018 Scholarship Australian Research Training Program The University of Adelaide Australia 2018 Scholarship Division of Health and Medical Science Scholarship The University of Adelaide Australia
Date Institution name Country Title 2018 - 2022 The University of Adelaide Australia PhD (Medicine) 2014 - 2015 University of KwaZulu-Natal South Africa Masters in Medical Research (Microbiology) 2008 - 2012 Kwame Nkrumah University of Science and Technology Ghana BSc. (Hons) degree in Biochemistry
Research InterestsBiochemistry & Molecular Biology Biochemistry and Cell Biology Bioinformatics Bioinformatics Software Developmental Genetics Medical Biochemistry and Metabolomics Medical Microbiology Medicinal and Biomolecular Chemistry Molecular Medicine Early Origins of Health Fertility and Conception Pregnancy and Birth
Year Citation 2022 Azumah, R., Hummitzsch, K., Hartanti, M. D., St John, J. C., Anderson, R. A., & Rodgers, R. J. (2022). Analysis of upstream regulators, networks, and pathways associated with the expression patterns of Polycystic Ovary Syndrome candidate genes during fetal ovary development. Frontiers in Genetics, 12, 762177-1-762177-16.
DOI Scopus1 WoS1
2022 Azumah, R., Liu, M., Hummitzsch, K., Bastian, N. A., Hartanti, M. D., Irving-Rodgers, H. F., . . . Rodgers, R. J. (2022). Candidate genes for polycystic ovary syndrome are regulated by TGFβ in the bovine foetal ovary. Human Reproduction, 37(6), 1244-1254.
2016 Chiwunze, T. E., Azumah, R., Ramtahal, M., Somboro, A. M., Arvidsson, P. I., Kruger, H. G., . . . Naicker, T. (2016). Organocatalyzed mannich reactions on minocycline: Towards novel tetracycline antibiotics. South African Journal of Chemistry, 69, 72-78.
DOI Scopus2 WoS2
2016 Azumah, R., Dutta, J., Somboro, A. M., Ramtahal, M., Chonco, L., Parboosing, R., . . . Govender, T. (2016). In vitro evaluation of metal chelators as potential metallo- β -lactamase inhibitors. Journal of Applied Microbiology, 120(4), 860-867.
DOI Scopus26 WoS26 Europe PMC13
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