Professor Guy Ludbrook
Professor
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Professor Guy L Ludbrook PhD, MBBS, FANZCAProfessor Ludbrook is Professor of Anaesthesia at the University of Adelaide and Royal Adelaide Hospital.Expertise:Health systems, health services, health economics, anaesthesia, medical devices, clinical trials - phase 1 to phase 3, He has published widely in the scientific literature with a particular focus on pharmacology and health system improvements. He is Director of an early phase clinical trials unit, PARC Clinical Research, located within the Royal Adelaide Hospital. He has been principle investigator on multiple clinical trials, both commercial and investigator-initiated, and sits on data safety monitoring boards for multiple international clinical trials. He is increasingly involved in health services review to optimise value in healthcare, and in the design and the study of new systems of care. Specialist Anaesthetist - MBBS FANZCAPharmacologist - PhDProfessor of Anaesthesia, Head of Acute Care Medicine, University of AdelaideDirector, PARC Clinical Research, Central Adelaide Local Health NetworkMember, Advisory Committee on Medical Devices, Therapeutics Goods Administration Education:London Business SchoolSenior Executive Program, Business2008 – 2008London School of EconomicsMasters in Health Economics, Policy and Management2018-2021Harvard Business SchoolLeading Health Care Organisations of Excellence2009 – 2009University of AdelaideMBBS PhD, Anaesthesia, Pharmacology1978 – 1993Australian Institute of Company DirectorsGraduate2016 – 2016
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Appointments
Date Position Institution name 2000 - ongoing Professor of Anaesthesia University of Adelaide, Adelaide 2000 - ongoing Professor of Anaesthesia and Senior Staff Specialist Royal Adelaide Hospital, Adelaide -
Education
Date Institution name Country Title University Of Adelaide Australia MBBS University Of Adelaide Australia PhD Australian and New Zealand College of Anaesthetists, Melbourne Australia FANZCA -
Certifications
Date Title Institution name Country 2008 Senior Executive Program London Business School, London United Kingdom -
Research Interests
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Journals
Year Citation 2025 Ludbrook, G., Leaman, E. E., Grocott, M. P. W., Royse, C., Sleigh, J., Clarke-Errey, S., & Solomon, L. B. (2025). Delayed Mortality in Patients Receiving Postoperative High-Acuity Care. JAMA Surgery, 160(3), 2 pages.
WoS1 Europe PMC12025 Oughton, C., Kusre, S., Riedel, B., & Ludbrook, G. (2025). Implementing Advanced Recovery Room Care Models to Enhance Economic and Patient Outcomes. Current Anesthesiology Reports, 15(1).
2025 Trewren, T., Fitzgerald, N., Jaensch, S., Nguyen, O., Tsymbal, A., Gao, C., . . . Bacchi, S. (2025). Artificial intelligence in perioperative medicine education: A feasibility test of case-based learning. Journal of Perioperative Practice, 17504589251346634.
Scopus1 Europe PMC12025 Zhang, C., Quigley, C., Pietris, J., Psaltis, A., Ludbrook, G., Rajak, S., & Selva, D. (2025). Throat pack usage in dacryocystorhinostomy (DCR)–systematic review & multicentre international survey revealing inconsistent practice and complications. Orbit, 9 pages.
2025 Ludbrook, G., Bryson, N., Taylor, B., Hocevar-Trnka, J., Johnson, M. W., Hirman, J., . . . Pollack, M. (2025). Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104: A Double-Blind, Randomized, Single Ascending Dose Placebo-Controlled Study. Journal of Clinical Psychopharmacology, 45(5), 441-453.
2025 Tran, L., Stern, C., Harford, P., Ludbrook, G., & Whitehorn, A. (2025). Effectiveness and Safety of Enhanced Postoperative Care Units for Noncardiac, Non-Neurological Surgery: A Systematic Review. A and A Practice, 19(8), e02008.
2025 Royse, A., Ren, J., Bowyer, A., Reid, C. M., Bellomo, R., Smith, J. A., . . . Royse, C. (2025). A Prospective, Multicentre Randomised Controlled Study of Angiographic and Clinical Outcomes in Total Arterial Coronary Bypass Grafting: The TA Trial Protocol. Heart Lung and Circulation.
Scopus12025 Cid-Serra, X., Royse, A., Bowyer, A., Canty, D., Sessler, D., Clarke-Errey, S., . . . Royse, C. (2025). Preoperative focused echocardiography on patients with fractured neck of femur. ECHONOF-III trial: study protocol for a multicenter randomized controlled trial. Trials, 26(1), 333.
2025 Meola, T. R., Ludbrook, G., Fornasini, G., Pavlova, O., Jain, S., Evans, A. M., & Reuter, S. E. (2025). Absolute bioavailability and intravenous pharmacokinetics of N-acetyl-D-mannosamine in humans. British Journal of Clinical Pharmacology.
2025 Glance, L. G., Grocott, M. P. W., Joynt Maddox, K. E., Scott, M. J., & Ludbrook, G. (2025). Transforming Postoperative Care: Advanced Recovery Room Care for Intermediate-risk Noncardiac Surgical Patients. Anesthesiology, 143(5), 1156-1159.
2024 Leaman, E. E., & Ludbrook, G. L. (2024). The Cost-Effectiveness of Early High-Acuity Postoperative Care for Medium-Risk Surgical Patients. Anesthesia and Analgesia, 139(2), 323-331.
Scopus6 WoS6 Europe PMC52024 Tran, L., Stern, C., Harford, P., Ludbrook, G., & Whitehorn, A. (2024). Effectiveness and safety of enhanced postoperative care units for non-cardiac, non-neurological surgery: a systematic review protocol.. JBI evidence synthesis, 22(8), 1626-1635.
Scopus4 WoS4 Europe PMC12024 Sammour, T., Watters, D. A., Harris, B., Grocott, M. P. W., & Ludbrook, G. L. (2024). Peri-operative care Summit II: building on the principles and framework identified at Summit I. ANZ Journal of Surgery, 94(9), 1447-1449.
Scopus1 WoS1 Europe PMC12024 Watters, D. A., Scott, D. A., Sammour, T., Harris, B., & Ludbrook, G. L. (2024). If the peri-operative patient pathway was right, what would it look like?. ANZ Journal of Surgery, 94(9), 1462-1470.
Scopus2 WoS1 Europe PMC12024 Ludbrook, G. L., Koning, N., & Sammour, T. (2024). Evaluation of enhanced recovery room care models.. Anaesthesia and intensive care, 53(3), 310057X241275110.
2023 Ludbrook, G., Grocott, M. P. W., Heyman, K., Clarke-Errey, S., Royse, C., Sleigh, J., & Solomon, L. B. (2023). Outcomes of Postoperative Overnight High-Acuity Care in Medium-Risk Patients Undergoing Elective and Unplanned Noncardiac Surgery.. JAMA surgery, 158(7), 701-708.
Scopus27 WoS28 Europe PMC202023 Fitzgerald, N., Thiruvenkatarajan, V., Brown-Beresford, K., Liu, W. M., Gupta, D., Van Wijk, R. M., & Ludbrook, G. L. (2023). Incidence and predictors of airway obstruction during high-flow nasal oxygen assisted procedural sedation during gastrointestinal interventions: A prospective observational study. Journal of Clinical Anesthesia, 89, 1-2.
Scopus1 WoS1 Europe PMC12023 Ludbrook, G. L., & Grocott, M. P. W. (2023). Estimating value in surgical and perioperative care: an essential component of quality. ANZ Journal of Surgery, 93(12), 2783-2785.
2023 Ludbrook, G., Grocott, M. P. W., & Clarke-Errey, S. (2023). Uncertain Definition of Medium Risk for Outcome Evaluation of Postoperative Overnight High-Acuity Care-Reply. JAMA surgery, 158(12), 1352-1353.
2022 Thiruvenkatarajan, V., Dharmalingam, A., Arenas, G., Wahba, M., Liu, W. -M., Zaw, Y., . . . collaborators. (2022). Effect of high-flow vs. low-flow nasal plus mouthguard oxygen therapy on hypoxaemia during sedation: a multicentre randomised controlled trial.. Anaesthesia, 77(1), 46-53.
Scopus21 WoS21 Europe PMC202022 Ludbrook, G. L. (2022). The Hidden Pandemic: the Cost of Postoperative Complications. Current Anesthesiology Reports, 12(1), 9 pages.
Scopus55 WoS53 Europe PMC462022 Malycha, J., Redfern, O., Pimentel, M., Ludbrook, G., Young, D., & Watkinson, P. (2022). Evaluation of a digital system to predict unplanned admissions to the intensive care unit: A mixed-methods approach. Resuscitation Plus, 9, 1-7.
Scopus12022 Thiruvenkatarajan, V., Wong, D. T., van Wijk, R., & Ludbrook, G. L. (2022). Comment on: “Efficacy of high flow nasal oxygenation against hypoxemia in sedated patients receiving gastrointestinal endoscopic procedures: A systematic review and meta-analysis”. Journal of Clinical Anesthesia, 78, 110689.
2022 Ludbrook, G. L., & Peden, C. J. (2022). Improving safety and outcomes in perioperative care: does implementation matter?. British Journal of Anaesthesia, 128(5), 747-751.
Scopus1 WoS1 Europe PMC12022 Kadam, V. R., Ludbrook, G. L., Hewett, P., & Westley, I. (2022). Plasma ropivacaine levels after ultrasound-guided erector spinae plane block and wound infiltration in laparoscopic colonic surgery - An observational study. Indian Journal of Anaesthesia, 66(3), 231-232.
Scopus3 WoS4 Europe PMC32022 Thiruvenkatarajan, V., Sekhar, V., Wong, D. T., Currie, J., van Wijk, R., & Ludbrook, G. L. (2022). Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.. Anaesthesia, 78(1), 12 pages.
Scopus28 WoS23 Europe PMC212022 Malycha, J., Andersen, C., Redfern, O. C., Peake, S., Subbe, C., Dykes, L., . . . Jones, D. (2022). Protocol describing a systematic review and mixed methods consensus process to define the deteriorated ward patient. . BMJ open, 12(9), e057614.
Scopus1 WoS1 Europe PMC12021 Ludbrook, G., Li, F., Sleigh, J., & Liang, Y. (2021). Retraction: Assessments of Onset and Duration of Drug Effects and Pharmacokinetics by Dose Level of HSK3486, a New Sedative-Hypnotic Agent, in Healthy Female/Male Subjects: A Phase I Multiarm Randomized Controlled Clinical Trial [Retracted (Anesthesia and analgesia (2021) 133 1 (e16)). Anesthesia and analgesia.
Scopus4 Europe PMC72021 Ludbrook, G. L., & Leaman, E. (2021). Cost-Effectiveness in Perioperative Care: Application of Markov Modeling to Pathways of Perioperative Care. Value in Health, 25(2), 215-221.
Scopus10 WoS7 Europe PMC32021 Rao Kadam, V., Ludbrook, G., van Wijk, R. M., Hewett, P., Thiruvenkatarajan, V., Edwards, S., . . . Adhikary, S. (2021). A comparison of ultrasound guided bilateral single injection shot Erector Spinae Plane blocks versus wound infiltration for post-operative analgesia in laparoscopic assisted colonic surgery- a prospective randomised study. BMC Anesthesiology, 21(1), 1-7.
Scopus8 WoS10 Europe PMC82021 Ludbrook, G., Lloyd, C., Story, D., Maddern, G., Riedel, B., Richardson, I., . . . Edwards, S. (2021). The effect of advanced recovery room care on postoperative outcomes in moderate-risk surgical patients: a multicentre feasibility study. Anaesthesia, 76(4), 480-488.
Scopus22 WoS20 Europe PMC152021 Ludbrook, G., Riedel, B., Martin, D., & Williams, H. (2021). Improving outcomes after surgery: a roadmap for delivering the value proposition in perioperative care. ANZ Journal of Surgery, 91(3), 225-228.
Scopus10 WoS9 Europe PMC92020 Malycha, J., Murphy, D., Barker, G., Ludbrook, G., Young, J. D., & Watkinson, P. J. (2020). Using real-time location devices (RTLD) to quantify off-unit adult intensive care registrar workload: a 1-year tertiary NHS hospital prospective observational study. Journal of Clinical Monitoring and Computing, 34(4), 805-809.
Scopus1 WoS1 Europe PMC12020 Lloyd, C., Proctor, L., Au, M., Story, D., Edwards, S., & Ludbrook, G. (2020). Incidence of early major adverse events after surgery in moderate-risk patients: early postoperative adverse events.. British journal of anaesthesia, 124(1), e9-e10.
Scopus12 Europe PMC92020 Rao Kadam, V., Ludbrook, G., van Wijk, R., Hewett, P., Thiruvenkatarajan, V., Moran, J., & Williams, P. (2020). Ultrasound-guided transmuscular quadratus lumborum block catheter technique: a reply. Anaesthesia, 75(3), 414-415.
Scopus2 WoS3 Europe PMC22020 Lloyd, C., Ludbrook, G., Story, D., & Maddern, G. (2020). 'Organisation of delivery of care in operating suite recovery rooms within 48 hours postoperatively and patient outcomes after adult non-cardiac surgery: a systematic review'. BMJ Open, 10(3), e027262-1-e027262-10.
Scopus11 WoS12 Europe PMC72020 Tran, A., Thiruvenkatarajan, V., Wahba, M., Currie, J., Rajbhoj, A., van Wijk, R., . . . Ludbrook, G. (2020). LMA® Gastro™ Airway for endoscopic retrograde cholangiopancreatography: a retrospective observational analysis.. BMC anesthesiology, 20(1), 113.
Scopus28 WoS24 Europe PMC182020 Thiruvenkatarajan, V., Dharmalingam, A., Arenas, G., Wahba, M., Steiner, R., Kadam, V. R., . . . Ludbrook, G. (2020). High-flow nasal cannula versus standard oxygen therapy assisting sedation during endoscopic retrograde cholangiopancreatography in high risk cases (OTHER): study protocol of a randomised multicentric trial.. Trials, 21(1), 444.
Scopus10 WoS9 Europe PMC72019 Kadam, V. R., Van Wijk, R. M., Ludbrook, G. L., & Thiruvenkatarajan, V. (2019). Anatomical and ultrasound description of two transmuscular quadratus lumborum block approaches at L2 level and their application in abdominal surgery. Anaesthesia and Intensive Care, 47(2), 141-145.
Scopus5 WoS5 Europe PMC32019 Malycha, J., Bonnici, T., Clifton, D. A., Ludbrook, G., Young, J. D., & Watkinson, P. J. (2019). Patient centred variables with univariate associations with unplanned ICU admission: a systematic review. BMC Medical Informatics and Decision Making, 19(1), 98-1-98-9.
Scopus15 WoS16 Europe PMC142019 Malycha, J., Farajidavar, N., Pimentel, M. A. F., Redfern, O., Clifton, D. A., Tarassenko, L., . . . Watkinson, P. J. (2019). The effect of fractional inspired oxygen concentration on early warning score performance: A database analysis. Resuscitation, 139, 192-199.
Scopus21 WoS17 Europe PMC212019 Rao Kadam, V., Ludbrook, G., van Wijk, R. M., Hewett, P. J., Moran, J. L., Thiruvenkatarajan, V., & Williams, P. J. (2019). Comparison of ultrasound-guided transmuscular quadratus lumborum block catheter technique with surgical pre-peritoneal catheter for postoperative analgesia in abdominal surgery: a randomised controlled trial. Anaesthesia, 74(11), 8 pages.
Scopus19 WoS21 Europe PMC162019 Malycha, J., Redfern, O. C., Ludbrook, G., Young, D., & Watkinson, P. J. (2019). Testing a digital system that ranks the risk of unplanned intensive care unit admission in all ward patients: Protocol for a prospective observational cohort study. BMJ Open, 9(9), 4 pages.
Scopus8 WoS6 Europe PMC62019 Grocott, M. P. W., & Ludbrook, G. L. (2019). Economic evaluation of prehabilitation: a true return on investment?. British Journal of Anaesthesia, 123(6), 710-712.
Scopus14 WoS12 Europe PMC102019 Ludbrook, G. L., & Walsh, R. M. (2019). Impact of age on the future burden of postoperative complications in Australia.. Anaesthesia and intensive care, 47(5), 480-481.
Scopus7 WoS7 Europe PMC72018 Jones, C. R., McCulloch, G. A. J., Ludbrook, G., Babidge, W. J., & Maddern, G. J. (2018). Deaths in incorrectly identified low-surgical-risk patients. World Journal of Surgery, 42(7), 1997-2000.
Scopus5 WoS4 Europe PMC32018 Ludbrook, G. (2018). Hidden pandemic of postoperative complications—time to turn our focus to health systems analysis. British Journal of Anaesthesia, 121(6), 1190-1192.
Scopus21 Europe PMC152017 Upton, H., Ludbrook, G., Wing, A., & Sleigh, J. (2017). Intraoperative "analgesia nociception index"-guided fentanyl administration during sevoflurane anesthesia in lumbar discectomy and laminectomy: A randomized clinical trial. Anesthesia and Analgesia, 125(1), 81-90.
Scopus82 WoS75 Europe PMC592017 Petersen Tym, M., Ludbrook, G., Flabouris, A., Seglenieks, R., & Painter, T. (2017). Developing models to predict early postoperative patient deterioration and adverse events. ANZ Journal of Surgery, 87(6), 457-461.
Scopus21 WoS18 Europe PMC152017 Ludbrook, G. L., & Goldsman, A. G. (2017). Coordinated perioperative care - A high value proposition?. British Journal of Anaesthesia, 118(1), 3-5.
Scopus3 WoS4 Europe PMC42016 Ha, T., van Renen, R., Ludbrook, G., & Wormald, P. (2016). The effect of blood pressure and cardiac output on the quality of the surgical field and middle cerebral artery blood flow during endoscopic sinus surgery. International Forum of Allergy and Rhinology, 6(7), 701-709.
Scopus26 WoS24 Europe PMC162016 Maiden, M., Chapman, M., Torpy, D., Kuchel, T., Clarke, I., Nash, C., . . . Ludbrook, G. (2016). Triiodothyronine administration in a model of septic shock: A randomized blinded placebo-controlled trial. Critical Care Medicine, 44(6), 1153-1160.
Scopus5 WoS7 Europe PMC62015 Ludbrook, G., Seglenieks, R., Osborn, S., & Grant, C. (2015). A call centre and extended checklist for pre-screening elective surgical patients - a pilot study. BMC Anesthesiology, 15(1), 77-1-77-6.
Scopus12 WoS11 Europe PMC82015 Ford, N., Ludbrook, G., & Galletly, C. (2015). Benzodiazepines may reduce the effectiveness of ketamine in the treatment of depression. Australian and New Zealand Journal of Psychiatry, 49(12), 1227.
Scopus21 WoS18 Europe PMC162014 Painter, T., & Ludbrook, G. (2014). Predicting patients at risk of early postoperative adverse. Anaesthesia and Intensive Care, 42(5), 649-656.
Scopus20 WoS16 Europe PMC122014 Dooney, N., Sundararajan, K., Ramkumar, T., Somogyi, A., Upton, R., Ong, J., . . . Ludbrook, G. (2014). Pharmacokinetics of tramadol after subcutaneous administration in a critically ill population and in a healthy cohort. BMC Anesthesiology, 14(1), 33-1-33-8.
Scopus8 WoS8 Europe PMC82014 Ha, T., van Renen, R., Ludbrook, G., Valentine, R., Ou, J., & Wormald, P. (2014). The relationship between hypotension, cerebral flow, and the surgical field during endoscopic sinus surgery. The Laryngoscope, 124(10), 2224-2230.
Scopus33 WoS23 Europe PMC162014 Painter, T., & Ludbrook, G. L. (2014). Reply from the authors. British Journal of Anaesthesia, 112(1), 172.
2013 Sutherland, J., & Ludbrook, G. (2013). Pre-admission processes and opportunities for improvement. Anaesthesia and Intensive Care, 41(3), 427-428.
Scopus12013 Painter, T., & Ludbrook, G. L. (2013). Reducing system errors in the preoperative assessment process. British Journal of Anaesthesia, 110(6), 1060-1061.
Scopus5 WoS7 Europe PMC52013 Ludbrook, G., O'Loughlin, E., Grant, C., & Corcoran, T. (2013). The relationship between patient data and pooled clinical management decisions. Anaesthesia and Intensive Care, 41(1), 57-65.
Scopus3 WoS3 Europe PMC32013 Freeman, B., Ludbrook, G., Hall, S., Cousins, M., Mitchell, B., Jaros, M., . . . Gorman, J. (2013). Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation. Spine, 38(23), 1986-1994.
Scopus63 WoS52 Europe PMC442012 Viscusi, E., Candiotti, K., Onel, E., Morren, M., & Ludbrook, G. (2012). The pharmacokinetics and pharmacodynamics of liposome bupivacaine administered via a single epidural injection to healthy volunteers. Regional Anesthesia and Pain Medicine, 37(6), 616-622.
Scopus66 WoS55 Europe PMC472012 Krishnamurthy, R., Upton, R., Fajumi, A., Lai, S., Charlton, C., Ousley, R., . . . Ludbrook, G. (2012). Pharmacokinetics of oxycodone after subcutaneous administration in a critically ill population compared with a healthy cohort. Anaesthesia and Intensive Care, 40(2), 269-274.
Scopus9 WoS6 Europe PMC42012 Grant, C., Ludbrook, G., O'Loughlin, E., & Corcoran, T. (2012). An analysis of computer-assisted pre-screening prior to elective surgery. Anaesthesia and Intensive Care, 40(2), 297-304.
Scopus19 WoS20 Europe PMC132012 Grant, C., Ludbrook, G. L., O'Loughlin, E. J., & Corcoran, T. B. (2012). An analysis of computer-assisted pre-screening prior to elective surgery (Anaesth Intensive Care (2012) 40, (207-394)). Anaesthesia and Intensive Care, 40(3), 530. 2011 Leslie, K., Wu, C. Y. X., Bjorksten, A. R., Williams, D. L., Ludbrook, G., & Williamson, E. (2011). Cardiac output and propofol concentrations in prone surgical patients. Anaesthesia and Intensive Care, 39(5), 868-874.
Scopus4 Europe PMC12010 Ho, J., Chapman, M., O'Connor, S., Lam, S., Edwards, J., Ludbrook, G., . . . Torpy, D. (2010). Characteristics of plasma NOx levels in severe sepsis: High interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. Clinical Endocrinology, 73(3), 413-420.
Scopus14 WoS13 Europe PMC112010 Capper, S., Loo, S., Geue, J., Upton, R., Ong, J., Macintyre, P., & Ludbrook, G. (2010). Pharmacokinetics of fentanyl after subcutaneous administration in volunteers. European Journal of Anaesthesiology, 27(3), 241-246.
Scopus24 WoS21 Europe PMC162009 Ludbrook, G., & Maddern, G. (2009). Doctor displacement: a political agenda or a health care imperative?. Medical Journal of Australia, 190(7), 396-397.
Scopus12008 Grant, C., Ludbrook, G., Hampson, E., Semenov, R., & Willis, R. (2008). Adverse physiological events under anaesthesia and sedation: a pilot audit of electronic patient records. Anaesthesia and Intensive Care, 36(2), 222-229.
Scopus22 WoS14 Europe PMC112008 Upton, R., Rasmussen, M., Grant, C., Martinez, A., Cold, G., & Ludbrook, G. (2008). Pharmacokinetics and pharmacodynamics of indomethacin: Effects on cerebral blood flow in anaesthetized sheep. Clinical and Experimental Pharmacology and Physiology, 35(3), 317-323.
Scopus10 WoS10 Europe PMC82007 Voss, L., Ludbrook, G., Grant, C., Upton, R., & Sleigh, J. (2007). A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep. Anesthesia and Analgesia, 104(6), 1440-1446.
Scopus20 WoS13 Europe PMC92007 Ludbrook, G., & Sutherland, P. (2007). Erroneous pulse oximetry readings during robotic prostatectomy. Anaesthesia and Intensive Care, 35(1), 144-145.
Scopus3 Europe PMC22007 Alkhazrajy, W., Macintyre, P., Upton, R., Ong, J., & Ludbrook, G. (2007). An audit of the safety and effectiveness of an alfentanil: morphine mixture in the postanaesthesia care unit. Acute Pain, 9(1), 13-19.
Scopus22006 Rasmussen, M., Upton, R., Grant, C., Martinez, A., Cold, G., & Ludbrook, G. (2006). The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. Anesthesia and Analgesia, 102(6), 1823-1829.
Scopus4 WoS2 Europe PMC22006 Voss, L., Ludbrook, G., Grant, C., Sleigh, J., & Barnard, J. (2006). Cerebral cortical effects of desflurane in sheep: comparison with isoflurane, sevoflurane and enflurane. Acta Anaesthesiologica Scandinavica, 50(3), 313-319.
Scopus30 WoS24 Europe PMC222006 Kalairajah, Y., Cossey, A., Verrall, G., Ludbrook, G., & Spriggins, A. (2006). Are systemic emboli reduced in computer-assisted knee surgery? A prospective, randomised, clinical trial. Journal of Bone and Joint Surgery-British Volume, 88B(2), 198-202.
Scopus126 Europe PMC812006 Kalairajah, Y., Cossey, A. J., Verrall, G. M., Ludbrook, G., & Spriggins, A. J. (2006). Erratum: Are systemic emboli reduced in computer-assisted knee surgery? A prospective, randomised, clinical trial (Journal of Boe and Joint Surgery - Series B (2006) vol 88-B (198-202)). Journal of Bone and Joint Surgery - Series B, 88(10), 1407. 2005 Upton, R., & Ludbrook, G. (2005). A physiologically based, recirculatory model of the kinetics and dynamics of propofol in man. Anesthesiology, 103(2), 344-352.
Scopus62 WoS48 Europe PMC392005 Westhorpe, R., Ludbrook, G., & Helps, S. (2005). Crisis management during anaesthesia: bronchospasm. Quality and Safety in Health Care, 14(3), e7/WWW 1-WWW 6.
Scopus56 WoS40 Europe PMC322005 Szekely, S., Runciman, W., Webb, R., & Ludbrook, G. (2005). Crisis management during anaesthesia: desaturation. Quality and Safety in Health Care, 14(3), e6/WWW 1-WWW 6.
Scopus22 WoS10 Europe PMC62005 Ludbrook, G., Webb, R., Currie, M., & Watterson, L. (2005). Crisis management during anaesthesia: myocardial ischaemia and infarction. Quality and Safety in Health Care, 14(3), e13/WWW 1-WWW 4.
Scopus8 WoS5 Europe PMC42005 Upton, R., & Ludbrook, G. (2005). Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs – method development and application to magnesium in sheep. BMC Pharmacology, 5(1), 5-1-5-22.
Scopus23 Europe PMC142004 Upton, R., Grant, C., Martinez, A., & Ludbrook, G. (2004). Recirculatory model of fentanyl disposition with the brain as the target organ. British Journal of Anaesthesia, 93(5), 687-697.
Scopus14 WoS13 Europe PMC122004 Sleigh, J., Steyn-Ross, D., Steyn-Ross, M., Grant, C., & Ludbrook, G. (2004). Cortical entropy changes with general anaesthesia: theory and experiment. Physiological Measurement, 25(4), 921-934.
Scopus88 WoS84 Europe PMC522003 Ludbrook, G., & Upton, R. (2003). Pharmacokinetic drug interaction between propofol and remifentanil?. Anesthesia and Analgesia, 97(3), 924-925.
Scopus12 WoS11 Europe PMC92003 Upton, R., Ludbrook, G., Martinez, A., Grant, C., & Milne, R. (2003). Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions. British Journal of Anaesthesia, 90(6), 750-758.
Scopus16 WoS16 Europe PMC132002 Myburgh, J., Upton, R., Ludbrook, G., Martinez, A., & Grant, C. (2002). Cerebrovascular carbon dioxide reactivity in sheep: Effect of propofol or isoflurane anaesthesia. Anaesthesia and Intensive Care, 30(4), 413-421.
Scopus13 WoS12 Europe PMC122002 Ludbrook, G., & Upton, R. (2002). Determinants of drug onset. Current Opinion in Anaesthesiology, 15(4), 409-414.
Scopus5 Europe PMC22002 Ludbrook, G., Visco, E., & Lam, A. (2002). Propofol: relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesia. Anesthesiology, 97(6), 1363-1370.
Scopus89 WoS72 Europe PMC692001 Zheng, D., Upton, R., Ludbrook, G., & Martinez, A. (2001). Acute cardiovascular effects of magnesium and their relationship to systemic and myocardial magnesium concentrations after short infusion in awake sheep. Journal of Pharmacology and Experimental Therapeutics, 297(3), 1176-1183.
Scopus14 WoS11 Europe PMC102001 Upton, R., Ludbrook, G., Grant, C., & Martinez, A. (2001). In vivo cerebral pharmacokinetics and pharmacodynamics of diazepam and midazolam after short intravenous infusion administration in sheep. Journal of Pharmacokinetics and Pharmacodynamics, 28(2), 129-153.
Scopus7 WoS6 Europe PMC52001 Upton, R., Ludbrook, G., & Grant, C. (2001). The cerebral and systemic kinetics of thiopentone and propofol in halothane anaesthetized sheep. Anaesthesia and Intensive Care, 29(2), 117-123.
Scopus5 WoS4 Europe PMC52001 Ludbrook, G., Macintyre, P., Douglas, H., Ong, J., & Upton, R. (2001). A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation. Anaesthesia, 56(8), 1-7.
Scopus8 WoS4 Europe PMC52001 Ludbrook, G., Macintyre, P., Douglas, H., Ong, L., & Upton, R. (2001). A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation.. Anaesthesia, 56(8), 739-744.
2000 Upton, R., Ludbrook, G., Grant, C., & Doolette, D. (2000). The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep. Anesthesiology, 93(4), 1085-1094.
Scopus37 WoS37 Europe PMC281999 Bessell, J., Ludbrook, G., Millard, S., Baxter, P., Ubhi, S., & Maddern, G. (1999). Humidified gas prevents hypothermia induced by laparoscopic insufflation. A randomized controlled study in a pig model. Surgical Endoscopy, 13(2), 101-105.
Scopus45 WoS47 Europe PMC411999 Ludbrook, G. L., James, M. F. M., & Upton, R. N. (1999). The effect of magnesium sulfate on cerebral blood flow velocity, cardiovascular variables, and arterial carbon dioxide tension in awake sheep. Journal of Neurosurgical Anesthesiology, 11(2), 96-101.
Scopus19 WoS13 Europe PMC101999 Upton, R. N., & Ludbrook, G. L. (1999). A model of the kinetics and dynamics of induction of anaesthesia in sheep: Variable estimation for thiopental and comparison with propofol. British Journal of Anaesthesia, 82(6), 890-899.
Scopus42 WoS40 Europe PMC301999 Upton, R., Ludbrook, G., Grant, C., & Martinez, A. (1999). Cardiac output is a determinant of the initial concentrations of Propofol after short-infusion administration. Anesthesia and Analgesia, 89(3), 545-552.
Scopus128 WoS113 Europe PMC701999 Ludbrook, G., Upton, R., Grant, C., & Martinez, A. (1999). Prolonged dysequilibrium between blood and brain concentrations of propofol during infusions in sheep. Acta Anaesthesiologica Scandinavica, 43(2), 206-211.
Scopus15 WoS12 Europe PMC91999 Ludbrook, G. L., Upton, R. N., Grant, C., & Martinez, A. (1999). A compartmental analysis of the pharmacokinetics of propofol in sheep. Journal of Pharmacokinetics and Biopharmaceutics, 27(3), 329-338.
Scopus13 WoS13 Europe PMC101999 Parsons, T. J., Upton, R. N., Martinez, A. M., & Ludbrook, G. L. (1999). No loss of undiluted propofol by sorption into administration systems. Pharmacy and Pharmacology Communications, 5(6), 377-381.
1998 Zheng, D., Upton, R., Martinez, A., Grant, C., & Ludbrook, G. (1998). The influence of the bolus injection rate of propofol on its cardiovascular effects and peak blood concentrations in sheep. Anesthesia and Analgesia, 86(5), 1109-1115.
Scopus32 WoS30 Europe PMC151998 Ludbrook, G., Upton, R., Grant, C., & Martinez, A. (1998). The effect of rate of administration on brain concentrations of propofol in sheep. Anesthesia and Analgesia, 86(6), 1301-1306.
Scopus29 WoS31 Europe PMC121997 Upton, R., Ludbrook, G., Gray, E., & Grant, C. (1997). The Cerebral Pharmacokinetics of Meperidine and Alfentanil in Conscious Sheep. Anesthesiology, 86(6), 1317-1325.
Scopus24 WoS23 Europe PMC191997 Huang, Y., Upton, R., Gray, E., Grant, C., Zheng, D., & Ludbrook, G. (1997). The effects of short intravenous infusions of thiopentone on myocardial function, blood flow and oxygen consumption in sheep. Anaesthesia and Intensive Care, 25(6), 627-633.
Scopus7 WoS5 Europe PMC51997 Ludbrook, G. L., Hitchcock, M., & Upton, R. N. (1997). The difficult airway: Propofol infusion as an alternative to gaseous induction. Anaesthesia and Intensive Care, 25(1), 71-73.
Scopus8 WoS8 Europe PMC61997 Ludbrook, G. L., & Upton, R. N. (1997). A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements. British Journal of Anaesthesia, 79(4), 505-513.
Scopus66 WoS58 Europe PMC421997 Upton, R. N., & Ludbrook, G. L. (1997). A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables. British Journal of Anaesthesia, 79(4), 497-504.
Scopus63 WoS56 Europe PMC411997 Ball, D. R., & Ludbrook, G. (1997). Propofol infusion for the difficult airway (multiple letters) [1]. Anaesthesia and Intensive Care, 25(5), 580-581.
Scopus3 Europe PMC21996 Ludbrook, G., Upton, R., Grant, C., & Gray, E. (1996). Cerebral effects of propofol following bolus administration in sheep. Anaesthesia and Intensive Care, 24(1), 26-31.
Scopus19 WoS15 Europe PMC81996 Ludbrook, G., Upton, R., Grant, C., & Gray, E. (1996). Brain and blood concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects. Anaesthesia and Intensive Care, 24(4), 445-452.
Scopus51 WoS49 Europe PMC331996 Upton, R. N., Huang, Y. F., Grant, C., Gray, E. C., & Ludbrook, G. L. (1996). Myocardial pharmacokinetics of thiopental in sheep after short-term administration: Relationship to thiopental-induced reductions in myocardial contractility. Journal of Pharmaceutical Sciences, 85(8), 863-867.
Scopus13 WoS13 Europe PMC91996 Mather, L., Upton, R., Huang, J., Ludbrook, G., Gray, E., & Grant, C. (1996). The systemic and cerebral kinetics of thiopental in sheep: enantiomeric analysis. Journal of Pharmacology and Experimental Therapeutics, 279(1), 291-297.
Scopus18 WoS16 Europe PMC111996 Upton, R., Ludbrook, G., Grant, C., & Gray, E. (1996). In vivo relationships between the cerebral pharmacokinetics and pharmacodynamics of thiopentone in sheep after short-term administration. Journal of Pharmacokinetics and Biopharmaceutics, 24(1), 1-18.
Scopus17 WoS16 Europe PMC91995 Ludbrook, G., Grant, C., Upton, R., & Penhall, C. (1995). A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus. Journal of Pharmacological and Toxicological Methods, 33(1), 17-22.
Scopus27 WoS23 Europe PMC211994 Bessell, J. R., Maddern, G. J., Manncke, K., Ludbrook, G., & Jamieson, G. G. (1994). Combined thoracoscopic and laparoscopic oesophagectomy and oesophagogastric reconstruction.. Endoscopic Surgery and Allied Technologies, 2(1), 32-36.
Scopus15 Europe PMC41994 Upton, R., Grant, C., & Ludbrook, G. (1994). An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep. Journal of Cerebral Blood Flow and Metabolism, 14(4), 680-688.
Scopus54 WoS51 Europe PMC421993 Singleton, R. J., Ludbrook, G. L., Webb, R. K., & Fox, M. A. L. (1993). Physical injuries and environmental safety in anaesthesia: An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 659-663.
Scopus19 WoS14 Europe PMC111993 Klepper, I. D., Webb, R. K., Van der Walt, J. H., Ludbrook, G. L., & Cockings, J. (1993). The stethoscope: Applications and limitations - An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 575-578.
Scopus26 WoS24 Europe PMC171993 Singleton, R. J., Webb, R. K., Ludbrook, G. L., & Fox, M. A. L. (1993). Problems associated with vascular access: An analysis of 200 incident reports. Anaesthesia and Intensive Care, 21(5), 664-669.
Scopus30 WoS17 Europe PMC201993 Ludbrook, G. L., Webb, R. K., Fox, M. A., & Singleton, R. J. (1993). Problems before induction of anaesthesia: An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 593-595.
Scopus11 WoS10 Europe PMC61993 Fox, M. A. L., Webb, R. K., Singleton, R., Ludbrook, G., & Runciman, W. B. (1993). Problems with regional anaesthesia: An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 646-649.
Scopus39 WoS341993 Ludbrook, G. L., Russell, W. J., Webb, R. K., Klepper, I. D., & Currie, M. (1993). The electrocardiograph: Applications and limitations - An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 558-564.
Scopus13 WoS14 Europe PMC111992 Ludbrook, G. L., Helps, S. C., Gorman, D. F., Reilly, P. L., North, J. B., & Grant, C. (1992). The relative effects of hypoxic hypoxia and carbon monoxide on brain function in rabbits. Toxicology, 75(1), 71-80.
Scopus14 WoS13 Europe PMC71992 Ludbrook, G. L., Helps, S. C., & German, D. F. (1992). Cerebral blood flow response to increases in arterial CO2 tension during alfentanil anesthesia in the rabbit. Journal of Cerebral Blood Flow and Metabolism, 12(3), 529-532.
Scopus10 WoS10 Europe PMC7 -
Book Chapters
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Conference Papers
Year Citation 2005 Stone, C., Humberstone, A. J., Gard'ner, K., Evans, A., Shaw, D., & Ludbrook, G. L. (2005). Steady-state pharmacokinetics of fentanyl after administration of a novel non-occlusive transdermal system.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 23 (pp. 778S). Orlando, FL: AMER SOC CLINICAL ONCOLOGY. -
Conference Items
Year Citation 2013 Maiden, M. J., Chapman, M. J., Torpy, D., Kuchel, T. R., Clarke, I., Nash, C. H., & Ludbrook, G. L. (2013). Tri-Iodothyronine (t3) Replacement In An Ovine Model Of Septic Shock. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Report for External Bodies
Year Citation 2002 Merlin, T. L., Hodgkinson, B., Macintyre, P., Ludbrook, G., & Hiller, J. E. (2002). Institutional approaches to pain assessment and management (008PAI): A systematic literature review. Melbourne, VIC: National Institute of Clinical Studies. -
Original Creative Works
Year Citation 2010 Authors: Jones J. Title: Responses. Description: Type of work : Poetry Extent : 1 p.. Extent: 1 p..
DOI
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2025 Principal Supervisor Health Economics in Perioperative Medicine: Optimising Resource Utilisation and Patient Outcomes through Predictive Modelling and AI Integration Doctor of Philosophy Doctorate Part Time Mr Esrom Leaman -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 - 2025 Co-Supervisor Effectiveness and safety of enhanced postoperative care units for non-cardiac surgery Master of Philosophy (Clinical Science) Master Full Time Dr Liem Tran 2021 - 2024 Principal Supervisor Improving the safety of sedation strategies during advanced gastrointestinal endoscopic interventions such as Endoscopic Retrograde Cholangiopancreatography Evaluation of high flow nasal oxygenation on preoxygenation parameters during airway management for general anaesthesia procedures Doctor of Philosophy Doctorate Part Time APrf Venkatesan Thiruvenkatarajan 2019 - 2023 Principal Supervisor Comparison of Ultrasound guided Erector Spinae Plane (ESP) block versus wound infiltration (Wl) for post-operative analgesia and safety assessed by estimation of blood levels of ropivacaine in laparoscopic colonic surgery- Prospective randomized study Doctor of Philosophy Doctorate Part Time Dr Vasanth Rao Kadam 2018 - 2020 Principal Supervisor Advanced Recovery Room Care Master of Clinical Science Master Part Time Dr Courtney Ellen Lloyd 2017 - 2022 Principal Supervisor Assessing the effects of implementing a novel risk prediction system on adults on acute wards requiring unplanned ICH admission Doctor of Philosophy Doctorate Part Time Dr James Lewis Malycha 2012 - 2020 Co-Supervisor The Effect of Hyperbaric Oxygen on Glucose Homeostasis Doctor of Philosophy Doctorate Part Time Dr David Wilkinson 2012 - 2017 Co-Supervisor Optimisation of Clinical Outcomes in Sinus Surgery Doctor of Philosophy Doctorate Full Time Dr Thanh Ngoc Ha 2010 - 2015 Principal Supervisor The Physiological Effects of Tri-Iodothyronine Supplementation in Ovine Septic Shock Doctor of Philosophy Doctorate Full Time Dr Matthew Jerome Maiden 2008 - 2008 Other MD submission Doctor of Medicine Doctorate Full Time APrf Athanasios Flabouris
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