Associate Professor Grigori Rychkov

Grigori Rychkov
University Senior Research Fellow - D
Adelaide Medical School
Faculty of Health and Medical Sciences

Liver Metabolism Group - Group Leader

This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.

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Associate Professor Grigori Rychkov

Liver Metabolism Group - Group Leader

This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.

Current Research Projects

1. The role of Store-operated Ca2+ channels in Ca2+ signalling
2. The role of TRP channels in liver physiology and pathology (with Prof Barritt)  
3. The role of TRP channels in mechanosensation in the gut (with Dr Brierley)
4. Mechanisms of oxygen sensitivity of TRPV3 channel (with Dr Peet)
5. Regulation of Na+ channels in lung epithelia (with Prof Kumar)
6. Differentiation of adult human dental pulp stem cells into functionally active neurons (with A/Prof Koblar and Prof Gronthos)

Appointments

Date Position Institution name
2014 University Senior Research Fellow (Level D) University of Adelaide
2013 University Senior Research Fellow (Level D) University of Adelaide
2010 - 2012 NHMRC Senior Research Fellow (Level D) University of Adelaide
2007 - 2009 NHMRC Senior Research Fellow (Level C) University of Adelaide
2002 - 2010 Visiting Senior Lecturer University of Adelaide
2002 - 2006 Australian Research Fellow University of Adelaide
1999 - 2001 Senior Research Associate University of South Australia
1994 - 1998 Research Associate University of South Australia
1990 - 1991 Lecturer Abkhazian State University
1988 - 1992 Research Associate USSR Medical Academy

Awards and Achievements

Date Type Title Institution Name Amount
2007 Fellowship NHMRC Senior Research Fellowship National Health and Medical Research Council
2002 Fellowship Australian Research Council Research Fellowship Australian Research Council
2002 Achievement Adjunct Senior Lecturer University of South Australia
1984 Scholarship Armenian Academy of Science Postgraduate Scholarship Armenian Academy of Science

Education

Date Institution name Country Title
1985 - 1987 Institute of Experimental Biology, Armenian Academy of Science Armenia, USSR PhD in Biological Sciences (Biophysics)
1979 - 1983 Rostov-on-Don State University Russia Bachelor of Science, Honours (Physics) and Bachelor of Education

Research Interests

Nutrition and Metabolic Health, Neuroscience, Behaviour and Brain Health

Journals

Year Citation
2017 Gavriliouk, D., Scrimgeour, N., Grigoryev, S., Ma, L., Zhou, F., Barritt, G. & Rychkov, G. (2017). Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH. Scientific Reports, 7, 1, -.
10.1038/s41598-017-06371-0
2017 Nagarajan, Y., Rychkov, G. & Peet, D. (2017). Modulation of TRP channel activity by hydroxylation and its therapeutic potential. Pharmaceuticals, 10, 2, 35-35.
10.3390/ph10020035
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A. ... Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7, 42810-1-42810-19.
10.1038/srep42810
2016 Ali, E., Hua, J., Wilson, C., Tallis, G., Zhou, F., Rychkov, G. & Barritt, G. (2016). The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca²⁺ signalling in steatotic hepatocytes. Biochimica et Biophysica Acta-Molecular Cell Research, 1863, 9, 2135-2146.
10.1016/j.bbamcr.2016.05.006
2016 Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X. ... Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534, 7608, 494-499.
10.1038/nature17976
2016 Zhang, W., Garg, S., Eldi, P., Zhou, F., Johnson, I., Brooks, D. ... Albrecht, H. (2016). Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide. International Journal of Pharmaceutics, 513, 1-2, 270-279.
10.1016/j.ijpharm.2016.09.039
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C. ... Brierley, S. (2016). Chronic oral administration of the guanylate cyclase-C agonist linaclotide attenuates colitis induced bladder afferent hyperactivity. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 29-29.
2016 Kheradpezhouh, E., Barritt, G. & Rychkov, G. (2016). Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. Redox Biology, 7, 1-7.
10.1016/j.redox.2015.11.001
2015 Karttunen, S., Duffield, M., Scrimgeour, N., Squires, L., Lim, W., Dallas, M. ... Peet, D. (2015). Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. Journal of Cell Science, 128, 2, 225-231.
10.1242/jcs.158451
2015 Wilson, C., Ali, E., Scrimgeour, N., Martin, A., Hua, J., Tallis, G. ... Barritt, G. (2015). Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism. Biochemical Journal, 466, 2, 379-390.
10.1042/BJ20140881
2014 Kheradpezhouh, E., Ma, L., Morphett, A., Barritt, G. & Rychkov, G. (2014). TRPM2 channels mediate acetaminophen-induced liver damage. Proceedings of the National Academy of Sciences of the United States of America, 111, 8, 3176-3181.
10.1073/pnas.1322657111
2014 Ellis, K., O'Carroll, D., Lewis, M., Rychkov, G. & Koblar, S. (2014). Neurogenic potential of dental pulp stem cells isolated from murine incisors. Stem Cell Research and Therapy, 5, 1, 30-1-30-13.
10.1186/scrt419
2014 Scrimgeour, N., Wilson, D., Barritt, G. & Rychkov, G. (2014). Structural and stoichiometric determinants of Ca2 + release-activated Ca2 + (CRAC) channel Ca2 +-dependent inactivation. Biochimica et Biophysica Acta - Biomembranes, 1838, 5, 1281-1287.
10.1016/j.bbamem.2014.01.019
2014 Ekberg, J., Boase, N., Rychkov, G., Manning, J., Poronnik, P. & Kumar, S. (2014). Nedd4-2 (NEDD4L) controls intracellular Na⁺ -mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochemical Journal, 457, 1, 27-31.
10.1042/BJ20131275
2013 Kilch, T., Alansary, D., Peglow, M., Dorr, K., Rychkov, G., Rieger, H. ... Niemeyer, B. (2013). Mutations of the ca²⁺-sensing stromal interaction molecule stim1 regulate ca²⁺ influx by altered oligomerization of stim1 and by destabilization of the ca²⁺ channel orai1. Journal of Biological Chemistry, 288, 3, 1653-1664.
10.1074/jbc.M112.417246
2012 Scrimgeour, N., Wilson, D. & Rychkov, G. (2012). Glu(106) in the Orai1 pore contributes to fast Ca(2+)-dependent inactivation and pH dependence of Ca(2+) release-activated Ca(2+) (CRAC) current. Biochemical Journal, 441, 2, 743-753.
10.1042/BJ20110558
2011 Ma, L., Rychkov, G., Bykova, E., Zheng, J. & Bretag, A. (2011). Movement of hCIC-1 C-termini during common gating and limits on their cytoplasmic location. Biochemical Journal, 436, 2, 415-428.
10.1042/BJ20102153
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G. & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589, 14, 3575-3593.
10.1113/jphysiol.2011.206789
2011 Rychkov, G. & Barritt, G. (2011). Expression and function of TRP channels in liver cells. Advances in Experimental Medicine and Biology, 704, 1-20.
10.1007/978-94-007-0265-3_35
2011 Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A. ... Cook, D. (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2, 1, 1-9.
10.1038/ncomms1284
2011 Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G. & Rychkov, G. (2011). The predominant role of IP₃ type 1 receptors in activation of store-operated Ca²⁺ entry in liver cells. Biochimica et Biophysica Acta-Biomembranes, 1808, 3, 745-751.
10.1016/j.bbamem.2010.12.013
2010 Cederholm, J., Rychkov, G., Bagley, C. & Bretag, A. (2010). Inter-subunit communication and fast gate integrity are important for common gating in hCIC-1. International Journal of Biochemistry & Cell Biology, 42, 7, 1182-1188.
10.1016/j.biocel.2010.04.004
2010 To, M., Aromataris, E., Castro, J., Roberts, M., Barritt, G. & Rychkov, G. (2010). Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca2+ current in liver cells. Archives of Biochemistry and Biophysics, 495, 2, 152-158.
10.1016/j.abb.2010.01.004
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G. & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3, 9, 2768-2798.
10.3390/ph3092768
2009 Castro, J., Aromataris, E., Rychkov, G. & Barritt, G. (2009). A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. Biochemical Journal, 418, Part 3, 553-566.
10.1042/BJ20081052
2009 Keating, D., Rychkov, G. & Roberts, M. (2009). The contribution of voltage-gated Ca²⁺ currents to K⁺ channel activation during ovine adrenal chromaffin cell development. International Journal of Developmental Neuroscience, 27, 4, 357-363.
10.1016/j.ijdevneu.2009.03.003
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T. ... Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137, 6, 2084-2095.
10.1053/j.gastro.2009.07.048
2009 Barritt, G., Litjens, T., Castro, J., Aromataris, E. & Rychkov, G. (2009). Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells. Clinical and Experimental Pharmacology and Physiology, 36, 1, 77-83.
10.1111/j.1440-1681.2008.05095.x
2009 Scrimgeour, N., Litjens, T., Ma, L., Barritt, G. & Rychkov, G. (2009). Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. Journal of Physiology-London, 587, 12, 2903-2918.
10.1113/jphysiol.2009.170662
2009 Ma, L., Rychkov, G. & Bretag, A. (2009). Functional study of cytoplasmic loops of human skeletal muscle chloride channel, hClC-1. International Journal of Biochemistry & Cell Biology, 41, 6, 1402-1409.
10.1016/j.biocel.2008.12.006
2008 Arthur, A., Rychkov, G., Shi, S., Koblar, S. & Gronthos, S. (2008). Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells, 26, 7, 1787-1795.
10.1634/stemcells.2007-0979
2008 Ma, L., Rychkov, G., Hughes, B. & Bretag, A. (2008). Analysis of carboxyl tail function in the skeletal muscle Cl⁻ channel hClC-1. Biochemical Journal, 413 Part 1, 1, 61-69.
10.1042/BJ20071489
2008 Barritt, G., Chen, J. & Rychkov, G. (2008). Ca²⁺-permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochimica et Biophysica Acta-Molecular Cell Research, 1783, 5, 651-672.
10.1016/j.bbamcr.2008.01.016
2008 Aromataris, E., Castro, J., Rychkov, G. & Barritt, G. (2008). Store-operated Ca2+ channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1783, 5, 874-885.
10.1016/j.bbamcr.2008.02.011
2007 Rychkov, G. & Barritt, G. (2007). TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of Experimental Pharmacology, 179, 179, 23-52.
10.1007/978-3-540-34891-7_2
2007 Litjens, T., Nguyen, T., Castro Kraftchenko, J., Aromataris, E., Jones, L., Barritt, G. & Rychkov, G. (2007). Phospholipase C-γ1 is required for the activation of store-operated Ca²⁺ channels in liver cells. Biochemical Journal, 405, 2, 269-276.
10.1042/BJ20061762
2006 Wu, W., Rychkov, G., Hughes, B. & Bretag, A. (2006). Functional complementation of truncated human skeletal-muscle chloride channel (hCIC-1) using carboxyl tail fragments. Biochemical Journal, 395, 1, 89-97.
10.1042/BJ20050966
2006 Aromataris, E., Roberts, M., Barritt, G. & Rychkov, G. (2006). Glucagon activates Ca2+ and Cl- channels in rat hepatocytes. Journal of Physiology-London, 573, 3, 611-625.
10.1113/jphysiol.2006.109819
2006 Aromataris, E. & Rychkov, G. (2006). ClC-1 chloride channel: Matching its properties to a role in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 33, 11, 1118-1123.
10.1111/j.1440-1681.2006.04502.x
2005 Keating, D., Rychkov, G., Giacomin, P. & Roberts, M. (2005). Oxygen-sensing pathway for SK channels in the ovine adrenal medulla. Clinical and Experimental Pharmacology and Physiology, 32, 10, 882-887.
10.1111/j.1440-1681.2010.04279.x
2005 Rychkov, G., Litjens, T., Roberts, M. & Barritt, G. (2005). ATP and vasopressin activate a single type of store-operated Ca2+ channel, identified by patch-clamp recording, in rat hepatocytes. Cell Calcium, 37, 2, 183-191.
10.1016/j.ceca.2004.09.001
2005 Bennetts, B., Rychkov, G., Ng, H., Morton, C., Stapleton, D., Parker, M. & Cromer, B. (2005). Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. Journal of Biological Chemistry, 280, 37, 32452-32458.
10.1074/jbc.M502890200
2005 Duffield, M., Rychkov, G., Bretag, A. & Roberts, M. (2005). Zinc inhibits human CIC-1 muscle chloride channel by interacting with its common gating mechanism. Journal of Physiology-London, 568, 1, 5-12.
10.1113/jphysiol.2005.091777
2005 Barritt, G. & Rychkov, G. (2005). TRPs as mechanosensitive channels. Nature Cell Biology, 7, 2, 105-107.
10.1038/ncb0205-105
2005 Rychkov, G., Litjens, T., Roberts, M. & Barritt, G. (2005). Arachidonic acid inhibits the store-operated Ca2+ current in rat liver cells. Biochemical Journal, 385, 2, 551-556.
10.1042/BJ20041604
2004 Simpson, B., Height, T., Rychkov, G., Nowak, K., Laing, N., Hughes, B. & Bretag, A. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression. Human Mutation, 731, 2, 1-7.
10.1002/humu.9260
2004 Keating, D., Rychkov, G., Adams, M., Holgert, H., McMillen, I. & Roberts, M. (2004). Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels. Journal of Physiology-London, 555, 2, 489-502.
10.1113/jphysiol.2003.056176
2004 Simpson, B., Height, T., Rychkov, G., Nowak, K., Laing, N., Hughes, B. & Bretag, A. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression.. Human mutation, 24, 2, 185-.
2004 Litjens, T., Harland, M., Roberts, M., Barritt, G. & Rychkov, G. (2004). Fast Ca2+-dependent inactivation of the store operated Ca2+ current (ISOC) in liver cells: a role for calmodulin. Journal of Physiology-London, 558, 1, 85-97.
10.1113/jphysiol.2004.065870
2003 Duffield, M., Rychkov, G., Bretag, A. & Roberts, M. (2003). Involvement of helices at the dimer interface in C1C-1 common gating. Journal of General Physiology, 121, 2, 149-161.
10.1085/jgp.20028741
2001 Rychkov, G., Pusch, M., Roberts, M. & Bretag, A. (2001). Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating. Journal of Physiology-London, 530, 3, 379-393.
10.1111/j.1469-7793.2001.0379k.x
2001 GREGORY, R. B., RYCHKOV, G. & BARRITT, G. J. (2001). Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochemical Journal, 354, 2, 285-285.
10.1042/0264-6021:3540285
2001 Gregory, R., Rychkov, G. & Barritt, G. (2001). Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochemical Journal, 354, 2, 285-290.
10.1042/bj3540285
2001 Bennetts, B., Roberts, M., Bretag, A. & Rychkov, G. (2001). Temperature dependence of human muscle ClC-1 chloride channel.. The Journal of physiology, 535, Pt 1, 83-93.
10.1111/j.1469-7793.2001.t01-1-00083.x
2001 Keating, D., Rychkov, G. & Roberts, M. (2001). Oxygen sensitivity in the sheep adrenal medulla: role of SK channels. American Journal of Physiology-Cell Physiology, 281, 5, C1434-C1441.
2001 Rychkov, G., Brereton, H., Harland, M. & Barritt, G. (2001). Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells. Hepatology, 33, 4, 938-947.
10.1053/jhep.2001.23051
2001 Brereton, H., Chen, J., Rychkov, G., Harland, M. & Barritt, G. (2001). Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1540, 2, 107-126.
10.1016/S0167-4889(01)00124-0
2001 Aromataris, E., Rychkov, G., Bennetts, B., Hughes, B., Bretag, A. & Roberts, M. (2001). Fast and slow gating of CLC-1: Differential effects of 2-(4-chlorophenoxy) propionic acid and dominant negative mutations. Molecular Pharmacology, 60, 1, 200-208.
10.1124/mol.60.1.200
2001 Rychkov, G., Pusch, M., Roberts, M. & Bretag, A. (2001). Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating.. The Journal of physiology, 530, Pt 3, 379-393.
10.1111/j.1469-7793.2001.0379k.x
2001 Bennetts, B., Roberts, M., Bretag, A. & Rychkov, G. (2001). Temperature dependence of human muscle ClC-1 chloride channel. Journal of Physiology-London, 535, 1, 83-93.
10.1111/j.1469-7793.2001.t01-1-00083.x
1999 Aromataris, E., Astill, D., Rychkov, G., Bryant, S., Bretag, A. & Roberts, M. (1999). Modulation of the gating of CIC-1 by S-(--) 2-(4-chlorophenoxy) propionic acid. British Journal of Pharmacology, 126, 6, 1375-1382.
10.1038/sj.bjp.0702459
1998 Rychkov, G., Adams, M., McMillen, I. & Roberts, M. (1998). Oxygen sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth. Journal of Physiology, 509, 3, 887-893.
10.1111/j.1469-7793.1998.887bm.x
1998 Rychkov, G., Pusch, M., Roberts, M., Jentsch, T. & Bretag, A. (1998). Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. Journal of General Physiology, 111, 5, 653-665.
10.1085/jgp.111.5.653
1998 Hryciw, D., Rychkov, G., Hughes, B. & Bretag, A. (1998). Relevance of the D13 region to the function of the skeletal muscle chloride channel, ClC-1. Journal of Biological Chemistry, 273, 8, 4304-4307.
10.1074/jbc.273.8.4304
1997 Rychkov, G., Astill, D., Bennetts, B., Hughes, B., Bretag, A. & Roberts, M. (1997). pH-dependent interactions of Cd2+ and a carboxylate blocker with the rat ClC-1 chloride channel and its R304E mutant in the Sf-9 insect cell line. Journal of Physiology, 501, 2, 355-362.
10.1111/j.1469-7793.1997.355bn.x
1996 Astill, D., Rychkov, G., Clarke, J., Hughes, B., Roberts, M. & Bretag, A. (1996). Characteristics of skeletal muscle chloride channel ClC-1 and point mutant R304E expressed in Sf-9 insect cells. Biochimica et Biophysica Acta - Biomembranes, 1280, 2, 178-186.
10.1016/0005-2736(95)00281-2
1996 Rychkov, G., Pusch, M., Astill, D., Roberts, M., Jentsch, T. & Bretag, A. (1996). Concentration and pH dependence of skeletal muscle chloride channel ClC-1.. The Journal of physiology, 497 ( Pt 2), 2, 423-435.
10.1113/jphysiol.1996.sp021778
1988 Aĭrapetian, S., Rychkov, G. & Suleĭmanian, M. (1988). [Modulation of calcium currents in the snail neuron membrane by osmotic gradient]. Doklady Akademii nauk SSSR, 300, 4, 983-985.
1988 Ayrapetyan, S., Rychkov, G. & Suleymanyan, M. (1988). Effects of water flow on transmembrane ionic currents in neurons of Helix pomatia and in squid giant axons.. Comparative biochemistry and physiology. A, Comparative physiology, 89, 2, 179-186.
10.1016/0300-9629(88)91076-6
1985 Aĭrapetian, S. & Rychkov, G. (1985). [The presence of reserve ion channels in membranes of giant snail neurons and giant squid axons]. Doklady Akademii nauk SSSR, 285, 6, 1464-1467.
1985 Aĭrapetian, S., Zakharian, R., Rychkov, G., Dadalian, S. & Bakunts, I. (1985). [dsRNA as a stimulant of cell pacemaker activity]. Doklady Akademii nauk SSSR, 284, 6, 1499-1502.

Book Chapters

Year Citation
2017 Ali, E., Rychkov, G. & Barritt, G. (2017). Metabolic disorders and cancer: Hepatocyte store-operated Ca2+ channels in nonalcoholic fatty liver disease. In K. Groschner, W. Graier & C. Romanin (Eds.), Store-Operated Ca2+ Entry (SOCE) Pathways : Emerging Signaling Concepts in Human (Patho)physiology (pp. 595-621). Switzerland: Springer.
10.1007/978-3-319-57732-6_30
2011 Rychkov, G. & Barritt, G. (2011). Expression and function of TRP channels in liver cells. In M. Islam (Ed.), Transient Receptor Potential Channels (pp. 667-686). 233 Spring St New York NY 10013: Springer.
10.1007/978-94-007-0265-3

Conference Papers

Year Citation
2011 Bretag, A. H., Ma, L., Rychkov, G. Y., Bykova, E. A. & Zheng, J. (2011). Using fluorescence resonance energy transfer (FRET) to reveal the basis for Thomsen's disease. 16th International Congress of the World-Muscle-Society. Algarve, PORTUGAL.
10.1016/j.nmd.2011.06.1040
2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K. ... Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. TRP channel Meeting Stockholm. Sweden.
2003 Duffield, M., Rychkov, G., Bretag, A. & Roberts, M. (2003). Effect of G, H and I domain mutations on ClC-1 slow gating. 47th Annual Meeting of the Biophysical-Society. SAN ANTONIO, TEXAS.
2003 Wu, W., Simpson, B., Rychkov, G., Hughes, B. & Bretag, A. (2003). Reconstitution of function in ClC-1: Coexpression of its transmembrane domain and small fragments of its carboxyl tail. 57th Annual Meeting of the Society-of-General-Physiologists. MARINE BIOL LAB, WOODS HOLE, MASSACHUSETTS.

Conference Items

Year Citation
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A. & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. 1st Federation Neurogastroenterology and Motility Scientific Meeting (FNM). Guangzhou, China.
10.1111/nmo.12412
2012 Kilch, T., Al-Ansary, D., Rychkov, G., Peinelt, C. & Niemeyer, B. A. (2012). STIM1 Mutants Modify CRAC by Altering Orai1 Protein Concentration. 56th Annual Meeting of the Biophysical-Society. San Diego, CA.
2008 Castro, J., Aromataris, E., Barritt, G. & Rychkov, G. (2008). Differential effects of cholestatic and choleretic bile acids on store-operated Ca2+ channels in liver [Abstract]. Annual Meeting of the Society of General Physiologists. Massachusetts, USA.
2008 Aromataris, E. C., Castro, J., Rychkov, G. Y. & Barritt, G. J. (2008). Bile acids modulate store-operated CA2+ channels and stromal interaction molecule1 (STIM1) distribution in liver cells. 43rd Annual Meeting of the European Association for the Study of the Liver. Milan, Italy.
10.1016/S0168-8278(08)60451-1
Date Project Title / No. Investigators Funding Body Amount
2015 – 2017 Novel regulation of TRP channels by oxygen-dependent hydroxylation   Peet, Rychkov and Gleadle ARC DP150102860 $364,000
2015 – 2017  The role of TRPM2 channels in oxidative stress-induced liver damage Rychkov, Barritt and Burt NHMRC APP1086817 $556,000
2014 – 2016 Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins
Rychkov and Barritt  
University of Adelaide, B3 Establishment Grant $390,000
2011 – 2013 Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity Brierley, Blackshaw and Rychkov NHMRC Project Grant $436,000
2008 Patch clamping and imaging cells in tissue slices Rychkov, Koblar, Gronthos, Kumar, Blackshaw, Brierley, Wilson, Beltrame and Peet NHMRC Equipment Grant $75,000
2008 - 2010 Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents Blackshaw, Brierley, Rychkov and Holtmann NHMRC Project Grant $641,000
2008 - 2010 STIM1 and Orai1 proteins in store-operated Ca2+ entry in liver Rychkov,  Barritt and Wilson NHMRC Project Grant $346,000
2007 – 2011   Rychkov NHMRC Senior Research Fellowship $537,500
2005 - 2007 Activation mechanisms of store-operated calcium channels in liver cells Rychkov and Barritt ARC Discovery Project $264,917
2002 - 2004 Store-operated calcium channels and liver function Rychkov, Barritt and Roberts NHMRC Project Grant $242,785
2002 - 2006 Regulatory mechanisms for calcium release-activated calcium channels Rychkov, Barritt, and Roberts ARC Discovery Project and Australian Research Fellowship $507,499
2002   Rychkov University of Adelaide, B3 Establishment Grant $11,000
2001 Towards chloride channel purification and rational treatment for myotonic muscle stiffness. Bretag, Rychkov ATN Small Grant $17,000
2000 Regulation of calcium sensitivity of exocytosis - novel function for the sulphonyrea receptor. Roberts, Rychkov ARC Small Grant $10,000
Date Course Title Role
2013                     Cellular & Systems Neurobiology Co-ordinator
2011 - 2013 Peripheral Sensory Functions Lecturer
2011 - 2013 Reflexes and Reflex testing Lecturer
2011 - 2013 Skin Physiology Lecturer
2011 - 2013 Ion channels and G-protein coupled receptors Lecturer
2011 - 2013 Cardiovascular Physiology and ANS Supervised practical
1995 - present  3rd year Research Projects of Biomedical Science and Physiology Science students Supervisor
1989 - 1991 Biophysics Lecturer
1989 - 1991 Introduction to molecular endocrinology Lecturer
1989 - 1991 Biomechanics Lecturer

Supervision of  honours students

Date Institution Student Name
2016 University of Adelaide Melissa Adams
2011 University of Adelaide Dan Gavrilouk
2008 University of South Australia Minh-Son To
2006 University of Adelaide Nathan Scrimgeour
2005 University of Adelaide Lynette Jones
2004 University of Adelaide Than Nguyen
2002 University of Adelaide Paul Giacomin
1995 University of Adelaide Brett Bennetts      

Supervision of PhD students

Date Role Student Name
2016 - current Co-supervisor Ms Andelain Ericson
2011 - 2015 Co-supervisor Mr Eunus Ali                                    
2010 - 2014 Primary Supervisor Mr Ehsan Kheradpezhouh                
2007 - 2011 Primary Supervisor Dr Nathan Scrimgeour
2006 - 2009 Primary Supervisor Mr Edoardo Aromataris
2005 - 2008 Co-supervisor Dr Linlin Ma  
2005 - 2008 Co-supervisor Dr Joel Castro
1999 - 2003 Co-supervisor Dr Michael Duffield
1998 - 2002 Co-supervisor Dr Damien Keating 
1997 - 2003 Co-supervisor Dr Brett Bennetts  

Supervision of postdoctoral researchers

Date Institution Researcher Name Researcher Position
2015 - current University of Adelaide Dr Fiona Zhou Postdoctoral Fellow
2015 - current University of Adelaide Dr Yagnesh Nagarajan Posdoctoral Fellow
2012 University of Alberta, Canada  Dr Bogdan Panaitescu Postdoctoral Fellow
2010 University of Adelaide Dr Claire Wilson               Postdoctoral Fellow
2009 - 2011 University of Adelaide Dr Linlin Ma                   Postdoctoral Fellow
2009 - 2012 Royal Adelaide Hospital Dr Andrea Harrington ARC Early Career Fellow
2008 - current Royal Adelaide Hospital Dr Stuart Brierley  NHMRC Career Development Fellowship
2008 - 2012 Discipline of Biochemistry, University of Adelaide  Dr Sarah Linke Postdoctoral Fellow
2006 University of Queensland Dr Jenny Ekberg Postdoctoral Fellow
2002 - 2007 University of Adelaide Dr Tom Litjens Postdoctoral Fellow
2001 Karolinska Institute, Sweden Dr Hans Holgert Postdoctoral Fellow 

 

Memberships

Date Role Membership Country
2007 - 2012 Member National Association of Research Fellows Australia
2003 - ongoing Member Society for General Physiologists Australia
1994 - ongoing Member Member of the Australian Physiological Society Australia

Committee Memberships

Date Role Committee Institution Country
2010 - 2013 Member School of Medical Sciences HDR Committee Australia
2008 - ongoing Member Medical and Scientific Research Advisory Committee of Muscular Dystrophy Association Muscular Dystrophy Association Australia
2007 - ongoing Member AuPS advisory committee on Cell Signalling Australia
1996 - ongoing Chair South Australian Facility for Patch Clamping and Confocal Microscopy University of Adelaide Australia

Offices Held

Date Office Name Institution Country
2014 - ongoing Postgraduate Coordinator South Australian Health and Medical Research Institute Australia
Position
University Senior Research Fellow - D
Phone
81284854
Campus
North Terrace West
Building
SAHMRI
Org Unit
Medical Specialties

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