Grigori Rychkov

Research Interests

Nutrition and Metabolic Health Neuroscience, Behaviour and Brain Health

APrf Grigori Rychkov

School of Pharmacy and Biomedical Science

College of Health

Liver Metabolism Group - Group Leader This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.

Current Research Projects

1. The role of Store-operated Ca2+ channels in Ca2+ signalling

2. The role of TRP channels in liver physiology and pathology (with Prof Barritt)  

3. The role of TRP channels in mechanosensation in the gut (with Dr Brierley)

4. Mechanisms of oxygen sensitivity of TRPV3 channel (with Dr Peet)

5. Regulation of Na+ channels in lung epithelia (with Prof Kumar)

6. Differentiation of adult human dental pulp stem cells into functionally active neurons (with A/Prof Koblar and Prof Gronthos)

Date Position Institution name
2014 - ongoing University Senior Research Fellow (Level D) University of Adelaide
2013 - ongoing University Senior Research Fellow (Level D) University of Adelaide
2010 - 2012 NHMRC Senior Research Fellow (Level D) University of Adelaide
2007 - 2009 NHMRC Senior Research Fellow (Level C) University of Adelaide
2002 - 2010 Visiting Senior Lecturer University of Adelaide
2002 - 2006 Australian Research Fellow University of Adelaide
1999 - 2001 Senior Research Associate University of South Australia
1994 - 1998 Research Associate University of South Australia
1990 - 1991 Lecturer Abkhazian State University
1988 - 1992 Research Associate USSR Medical Academy

Date Type Title Institution Name Country Amount
2007 Fellowship NHMRC Senior Research Fellowship National Health and Medical Research Council Australia -
2002 Fellowship Australian Research Council Research Fellowship Australian Research Council Australia -
2002 Achievement Adjunct Senior Lecturer University of South Australia Australia -
1984 Scholarship Armenian Academy of Science Postgraduate Scholarship Armenian Academy of Science Armenia -

Date Institution name Country Title
1985 - 1987 Institute of Experimental Biology, Armenian Academy of Science Armenia, USSR PhD in Biological Sciences (Biophysics)
1979 - 1983 Rostov-on-Don State University Russia Bachelor of Science, Honours (Physics) and Bachelor of Education

Year Citation
2025 Wang, Q., McGovern, A. E., Kyloh, M., Rychkov, G., Spencer, N. J., Mazzone, S. B., . . . Harrington, A. M. (2025). Splanchnic and Pelvic Spinal Afferent Pathways Relay Sensory Information From the Mouse Colorectum Into Distinct Brainstem Circuits. Journal of Neurochemistry, 169(9), e70211.
DOI Scopus1 WoS2 Europe PMC2
2025 Ricos, M. G., Cole, B. A., Hussain, R., Rychkov, G. Y., Shaukat, Z., Pilati, N., . . . Lippiat, J. D. (2025). Identification of new KCNT1-epilepsy drugs by In silico, cell, and drosophila modeling. Annals Of Neurology, online(6), 1-14.
DOI
2024 Hussain, R., Lim, C. X., Shaukat, Z., Islam, A., Caseley, E. A., Lippiat, J. D., . . . Dibbens, L. M. (2024). Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy. Scientific Reports, 14(1, article no. 3357), 3357-1-3357-12.
DOI Scopus8 WoS8 Europe PMC8
2023 Wang, Q. Q., Caraballo, S. G., Rychkov, G., McGovern, A. E., Mazzone, S. B., Brierley, S. M., & Harrington, A. M. (2023). Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex. Journal of Comparative Neurology, 532(2), e25546-1-e25546-32.
DOI Scopus7 WoS7 Europe PMC5
2022 Liu, D., Rychkov, G., Hurtado, P., Luo, H. Y., Zhang, T., Bobrovskaya, L., & Zhou, X. F. (2022). Conversion of human fibroblasts into induced neural stem cells by small molecules. International Journal of Molecular Sciences, 23(3, article no. 1740), 1-12.
DOI Scopus5 WoS5 Europe PMC4
2022 Wang, B. B., Xu, H., Isenmann, S., Huang, C., Elorza-Vidal, X., Rychkov, G. Y., . . . Apaja, P. M. (2022). Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca²⁺-induced proteostasis disease stress. Cellular and molecular life sciences : CMLS, 79(3), 167-1-167-22.
DOI Scopus9 WoS7 Europe PMC9
2022 Rychkov, G. Y., Shaukat, Z., Lim, C. X., Hussain, R., Roberts, B. J., Bonardi, C. M., . . . Dibbens, L. M. (2022). Functional effects of Epilepsy associated KCNT1 mutations suggest pathogenesis via aberrant inhibitory neuronal activity. International Journal of Molecular Sciences, 23(23, article no. 15133), 1-14.
DOI Scopus12 WoS9 Europe PMC12
2021 Ali, E. S., Rychkov, G. Y., & Barritt, G. J. (2021). Trpm2 non-selective cation channels in liver injury mediated by reactive oxygen species. Antioxidants, 10(8), 26 pages.
DOI Scopus31 WoS29 Europe PMC23
2021 Rychkov, G. Y., Zhou, F. H., Adams, M. K., Brierley, S. M., Ma, L., & Barritt, G. J. (2021). Orai1- and Orai2-, but not Orai3-mediated ⁄CRAC is regulated by intracellular pH. The Journal of Physiology, 600(3), 1-12.
DOI Scopus7 WoS5 Europe PMC8
2020 Rychkov, G., Zhou, F., Adams, M., Brierley, S., Ma, L., & Barritt, G. (2020). Orai1- and Orai2-, but not Orai3-mediated ICRAC is regulated by intracellular pH.
DOI
2020 Ali, E. S., Rychkov, G. Y., & Barritt, G. J. (2020). Targeting ca<sup>2+</sup> signaling in the initiation, promotion and progression of hepatocellular carcinoma. Cancers, 12(10), 1-33.
DOI Scopus14 WoS13 Europe PMC12
2020 Liu, D., Rychkov, G., Al-Hawwas, M., Manaph, N. P. A., Zhou, F., Bobrovskaya, L., . . . Zhou, X. -F. (2020). Conversion of human urine-derived cells into neuron-like cells by small molecules. Molecular Biology Reports, 47(4), 1-10.
DOI Scopus17 WoS18 Europe PMC16
2019 Ali, E. S., Rychkov, G. Y., & Barritt, G. J. (2019). Deranged hepatocyte intracellular Ca²⁺ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma. Cell Calcium, 82, 102057-1-102057-15.
DOI Scopus48 WoS41 Europe PMC38
2018 Kheradpezhouh, E., Zhou, F., Barritt, G., & Rychkov, G. (2018). Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes. Biochemical and Biophysical Research Communications, 503(3), 1891-1896.
DOI Scopus16 WoS15 Europe PMC13
2018 Grundy, L., Erickson, A., Caldwell, A., Garcia-Caraballo, S., Rychkov, G., Harrington, A., & Brierley, S. (2018). Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension. Pain, 159(12), 2573-2584.
DOI Scopus26 WoS29 Europe PMC23
2018 Grundy, L., Harrington, A. M., Castro, J., Garcia-Caraballo, S., Deiteren, A., Maddern, J., . . . Brierley, S. M. (2018). Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction. JCI Insight, 3(19), e121841-1-e121841-20.
DOI Scopus63 WoS60 Europe PMC58
2018 Castro, J., Grundy, L., Deiteren, A., Harrington, A., O'Donnell, T., Maddern, J., . . . Brierley, S. (2018). Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology, 175(12), 2384-2398.
DOI Scopus40 WoS34 Europe PMC31
2018 Salvatierra, J., Castro, J., Erickson, A., Li, Q., Braz, J., Gilchrist, J., . . . Bosmans, F. (2018). NaV1.1 inhibition can reduce visceral hypersensitivity. JCI insight, 3(11), e121000-1-e121000-13.
DOI Scopus32 WoS33 Europe PMC30
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A., . . . Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7(1), 42810-1-42810-19.
DOI Scopus63 WoS62 Europe PMC57
2017 Nagarajan, Y., Rychkov, G., & Peet, D. (2017). Modulation of TRP channel activity by hydroxylation and its therapeutic potential. Pharmaceuticals, 10(2), 35.
DOI Scopus9 WoS9 Europe PMC6
2017 Gavriliouk, D., Scrimgeour, N., Grigoryev, S., Ma, L., Zhou, F., Barritt, G., & Rychkov, G. (2017). Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH. Scientific Reports, 7(1), 9829-1-9829-12.
DOI Scopus14 WoS14 Europe PMC11
2016 Grundy, L. A., Garcia-Carraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C. B., . . . Brierley, S. (2016). Chronic Oral Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity. GASTROENTEROLOGY, 150(4), S118-S119.
DOI WoS3
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C., . . . Brierley, S. M. (2016). COLITIS INDUCES LONG-TERM BLADDER AFFERENT HYPERACTIVITY, WHICH IS ATTENUATED BY CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE. JOURNAL OF UROLOGY, 195(4), E373.
DOI
2016 Kheradpezhouh, E., Barritt, G., & Rychkov, G. (2016). Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. Redox Biology, 7, 1-7.
DOI Scopus66 WoS54 Europe PMC49
2016 Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X., . . . Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534(7608), 494-499.
DOI Scopus256 WoS243 Europe PMC218
2016 Zhang, W., Garg, S., Eldi, P., Zhou, F., Johnson, I., Brooks, D., . . . Albrecht, H. (2016). Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide. International Journal of Pharmaceutics, 513(1-2), 270-279.
DOI Scopus28 WoS25 Europe PMC17
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C., . . . Brierley, S. M. (2016). Chronic oral administration of the guanylate cyclase-C agonist linaclotide attenuates colitis induced bladder afferent hyperactivity. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 29.
2016 Ali, E., Hua, J., Wilson, C., Tallis, G., Zhou, F., Rychkov, G., & Barritt, G. (2016). The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca²⁺ signalling in steatotic hepatocytes. Biochimica et Biophysica Acta-Molecular Cell Research, 1863(9), 2135-2146.
DOI Scopus40 WoS36 Europe PMC27
2015 Karttunen, S., Duffield, M., Scrimgeour, N., Squires, L., Lim, W., Dallas, M., . . . Peet, D. (2015). Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. Journal of Cell Science, 128(2), 225-231.
DOI Scopus38 WoS38 Europe PMC30
2015 Wilson, C., Ali, E., Scrimgeour, N., Martin, A., Hua, J., Tallis, G., . . . Barritt, G. (2015). Steatosis inhibits liver cell store-operated Ca2 + entry and reduces ER Ca2 + through a protein kinase C-dependent mechanism. Biochemical Journal, 466(2), 379-390.
DOI Scopus78 WoS71 Europe PMC60
2014 Ellis, K., O'Carroll, D., Lewis, M., Rychkov, G., & Koblar, S. (2014). Neurogenic potential of dental pulp stem cells isolated from murine incisors. Stem Cell Research and Therapy, 5(1), 30-1-30-13.
DOI Scopus60 WoS48 Europe PMC43
2014 Kheradpezhouh, E., Ma, L., Morphett, A., Barritt, G., & Rychkov, G. (2014). TRPM2 channels mediate acetaminophen-induced liver damage. Proceedings of the National Academy of Sciences of the United States of America, 111(8), 3176-3181.
DOI Scopus87 WoS84 Europe PMC72
2014 Scrimgeour, N., Wilson, D., Barritt, G., & Rychkov, G. (2014). Structural and stoichiometric determinants of Ca2 + release-activated Ca2 + (CRAC) channel Ca2 +-dependent inactivation. Biochimica et Biophysica Acta - Biomembranes, 1838(5), 1281-1287.
DOI Scopus15 WoS15 Europe PMC11
2014 Ekberg, J., Boase, N., Rychkov, G., Manning, J., Poronnik, P., & Kumar, S. (2014). Nedd4-2 (NEDD4L) controls intracellular Na⁺ -mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochemical Journal, 457(1), 27-31.
DOI Scopus33 WoS33 Europe PMC32
2013 Kilch, T., Alansary, D., Peglow, M., Dorr, K., Rychkov, G., Rieger, H., . . . Niemeyer, B. (2013). Mutations of the ca²⁺-sensing stromal interaction molecule stim1 regulate ca²⁺ influx by altered oligomerization of stim1 and by destabilization of the ca²⁺ channel orai1. Journal of Biological Chemistry, 288(3), 1653-1664.
DOI Scopus63 WoS58 Europe PMC49
2012 Scrimgeour, N., Wilson, D., & Rychkov, G. (2012). Glu(106) in the Orai1 pore contributes to fast Ca(2+)-dependent inactivation and pH dependence of Ca(2+) release-activated Ca(2+) (CRAC) current. Biochemical Journal, 441(2), 743-753.
DOI Scopus35 WoS35 Europe PMC30
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593.
DOI Scopus120 WoS109 Europe PMC110
2011 Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G., & Rychkov, G. (2011). The predominant role of IP₃ type 1 receptors in activation of store-operated Ca²⁺ entry in liver cells. Biochimica et Biophysica Acta-Biomembranes, 1808(3), 745-751.
DOI Scopus5 WoS5 Europe PMC3
2011 Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., . . . Cook, D. (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9.
DOI Scopus84 WoS79 Europe PMC75
2011 Ma, L., Rychkov, G., Bykova, E., Zheng, J., & Bretag, A. (2011). Movement of hCIC-1 C-termini during common gating and limits on their cytoplasmic location. Biochemical Journal, 436(2), 415-428.
DOI Scopus26 WoS25 Europe PMC27
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G., & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3(9), 2768-2798.
DOI Scopus14 WoS11 Europe PMC10
2010 To, M., Aromataris, E., Castro, J., Roberts, M., Barritt, G., & Rychkov, G. (2010). Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca2+ current in liver cells. Archives of Biochemistry and Biophysics, 495(2), 152-158.
DOI Scopus39 WoS38 Europe PMC30
2010 Cederholm, J., Rychkov, G., Bagley, C., & Bretag, A. (2010). Inter-subunit communication and fast gate integrity are important for common gating in hCIC-1. International Journal of Biochemistry & Cell Biology, 42(7), 1182-1188.
DOI Scopus24 WoS23 Europe PMC23
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095.
DOI Scopus242 WoS218 Europe PMC199
2009 Keating, D., Rychkov, G., & Roberts, M. (2009). The contribution of voltage-gated Ca²⁺ currents to K⁺ channel activation during ovine adrenal chromaffin cell development. International Journal of Developmental Neuroscience, 27(4), 357-363.
DOI Scopus4 WoS4 Europe PMC3
2009 Scrimgeour, N., Litjens, T., Ma, L., Barritt, G., & Rychkov, G. (2009). Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. Journal of Physiology-London, 587(12), 2903-2918.
DOI Scopus125 WoS112 Europe PMC111
2009 Ma, L., Rychkov, G., & Bretag, A. (2009). Functional study of cytoplasmic loops of human skeletal muscle chloride channel, hClC-1. International Journal of Biochemistry & Cell Biology, 41(6), 1402-1409.
DOI Scopus6 WoS5 Europe PMC5
2009 Castro, J., Aromataris, E., Rychkov, G., & Barritt, G. (2009). A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. Biochemical Journal, 418(Part 3), 553-566.
DOI Scopus24 WoS23 Europe PMC17
2009 Barritt, G., Litjens, T., Castro, J., Aromataris, E., & Rychkov, G. (2009). Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells. Clinical and Experimental Pharmacology and Physiology, 36(1), 77-83.
DOI Scopus25 WoS22 Europe PMC19
2008 Arthur, A., Rychkov, G., Shi, S., Koblar, S., & Gronthos, S. (2008). Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells, 26(7), 1787-1795.
DOI Scopus532 WoS489 Europe PMC425
2008 Ma, L., Rychkov, G., Hughes, B., & Bretag, A. (2008). Analysis of carboxyl tail function in the skeletal muscle Cl⁻ channel hClC-1. Biochemical Journal, 413 Part 1(1), 61-69.
DOI Scopus7 WoS5 Europe PMC6
2008 Aromataris, E., Castro, J., Rychkov, G., & Barritt, G. (2008). Store-operated Ca2+ channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(5), 874-885.
DOI Scopus27 WoS24 Europe PMC16
2008 Barritt, G., Chen, J., & Rychkov, G. (2008). Ca²⁺-permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(5), 651-672.
DOI Scopus55 WoS50 Europe PMC39
2007 Rychkov, G., & Barritt, G. (2007). TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of Experimental Pharmacology, 179(179), 23-52.
DOI Scopus75 Europe PMC55
2007 Litjens, T., Nguyen, T., Castro Kraftchenko, J., Aromataris, E., Jones, L., Barritt, G., & Rychkov, G. (2007). Phospholipase C-γ1 is required for the activation of store-operated Ca²⁺ channels in liver cells. Biochemical Journal, 405(2), 269-276.
DOI Scopus32 WoS31 Europe PMC25
2006 Aromataris, E., & Rychkov, G. (2006). ClC-1 chloride channel: Matching its properties to a role in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 33(11), 1118-1123.
DOI Scopus22 WoS24 Europe PMC23
2006 Aromataris, E., Roberts, M., Barritt, G., & Rychkov, G. (2006). Glucagon activates Ca2+ and Cl- channels in rat hepatocytes. Journal of Physiology-London, 573(3), 611-625.
DOI Scopus60 WoS52 Europe PMC45
2006 Wu, W., Rychkov, G., Hughes, B., & Bretag, A. (2006). Functional complementation of truncated human skeletal-muscle chloride channel (hCIC-1) using carboxyl tail fragments. Biochemical Journal, 395(1), 89-97.
DOI Scopus15 WoS15 Europe PMC15
2005 Barritt, G., & Rychkov, G. (2005). TRPs as mechanosensitive channels. Nature Cell Biology, 7(2), 105-107.
DOI Scopus41 WoS38 Europe PMC29
2005 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2005). Zinc inhibits human CIC-1 muscle chloride channel by interacting with its common gating mechanism. Journal of Physiology-London, 568(1), 5-12.
DOI Scopus23 WoS20 Europe PMC17
2005 Keating, D., Rychkov, G., Giacomin, P., & Roberts, M. (2005). Oxygen-sensing pathway for SK channels in the ovine adrenal medulla. Clinical and Experimental Pharmacology and Physiology, 32(10), 882-887.
DOI Scopus26 WoS27 Europe PMC22
2005 Bennetts, B., Rychkov, G., Ng, H., Morton, C., Stapleton, D., Parker, M., & Cromer, B. (2005). Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. Journal of Biological Chemistry, 280(37), 32452-32458.
DOI Scopus108 WoS102 Europe PMC94
2005 Rychkov, G., Litjens, T., Roberts, M., & Barritt, G. (2005). ATP and vasopressin activate a single type of store-operated Ca2+ channel, identified by patch-clamp recording, in rat hepatocytes. Cell Calcium, 37(2), 183-191.
DOI Scopus30 WoS25 Europe PMC25
2005 Rychkov, G., Litjens, T., Roberts, M., & Barritt, G. (2005). Arachidonic acid inhibits the store-operated Ca2+ current in rat liver cells. Biochemical Journal, 385(2), 551-556.
DOI Scopus25 WoS23 Europe PMC22
2004 Litjens, T., Harland, M., Roberts, M., Barritt, G., & Rychkov, G. (2004). Fast Ca2+-dependent inactivation of the store operated Ca2+ current (ISOC) in liver cells: a role for calmodulin. Journal of Physiology-London, 558(1), 85-97.
DOI Scopus51 WoS48 Europe PMC43
2004 Simpson, B., Height, T., Rychkov, G., Nowak, K., Laing, N., Hughes, B., & Bretag, A. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression. Human Mutation, 731(2), 1-7.
DOI Europe PMC24
2004 Keating, D., Rychkov, G., Adams, M., Holgert, H., McMillen, I., & Roberts, M. (2004). Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels. Journal of Physiology-London, 555(2), 489-502.
DOI Scopus19 WoS18 Europe PMC16
2004 Simpson, B. J., Height, T. A., Rychkov, G. Y., Nowak, K. J., Laing, N. G., Hughes, B. P., & Bretag, A. H. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression.. Human Mutation, 24(2), 185.
DOI Scopus31
2003 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2003). Involvement of helices at the dimer interface in C1C-1 common gating. Journal of General Physiology, 121(2), 149-161.
DOI Scopus103 WoS94 Europe PMC84
2001 Aromataris, E., Rychkov, G., Bennetts, B., Hughes, B., Bretag, A., & Roberts, M. (2001). Fast and slow gating of CLC-1: Differential effects of 2-(4-chlorophenoxy) propionic acid and dominant negative mutations. Molecular Pharmacology, 60(1), 200-208.
DOI Scopus28 WoS25 Europe PMC21
2001 Bennetts, B., Roberts, M., Bretag, A., & Rychkov, G. (2001). Temperature dependence of human muscle ClC-1 chloride channel. Journal of Physiology-London, 535(1), 83-93.
DOI Scopus48 WoS43
2001 Rychkov, G., Pusch, M., Roberts, M., & Bretag, A. (2001). Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating. Journal of Physiology-London, 530(3), 379-393.
DOI Scopus33 WoS33 Europe PMC25
2001 Rychkov, G., Brereton, H., Harland, M., & Barritt, G. (2001). Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells. Hepatology, 33(4), 938-947.
DOI Scopus61 WoS58 Europe PMC53
2001 Brereton, H., Chen, J., Rychkov, G., Harland, M., & Barritt, G. (2001). Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1540(2), 107-126.
DOI Scopus46 WoS40 Europe PMC40
2001 Gregory, R., Rychkov, G., & Barritt, G. (2001). Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochemical Journal, 354(2), 285-290.
DOI Scopus172 WoS168 Europe PMC105
2001 Keating, D., Rychkov, G., & Roberts, M. (2001). Oxygen sensitivity in the sheep adrenal medulla: role of SK channels. American Journal of Physiology-Cell Physiology, 281(5), C1434-C1441.
DOI Scopus48 WoS40 Europe PMC31
2001 GREGORY, R. B., RYCHKOV, G., & BARRITT, G. J. (2001). Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochemical Journal, 354(2), 285.
DOI
2001 Bennetts, B., Roberts, M. L., Bretag, A. H., & Rychkov, G. Y. (2001). Temperature dependence of human muscle ClC-1 chloride channel.. The Journal of physiology, 535(Pt 1), 83-93.
DOI Europe PMC40
2001 Aromataris, E. C., Rychkov, G., Bennetts, B., Hughes, B. P., Bretag, A. H., & Roberts, M. (2001). Fast and slow gating of CLC-1. Molecular pharmacology.
1999 Aromataris, E., Astill, D., Rychkov, G., Bryant, S., Bretag, A., & Roberts, M. (1999). Modulation of the gating of CIC-1 by S-(--) 2-(4-chlorophenoxy) propionic acid. British Journal of Pharmacology, 126(6), 1375-1382.
DOI Scopus38 WoS36 Europe PMC29
1998 Rychkov, G., Pusch, M., Roberts, M., Jentsch, T., & Bretag, A. H. (1998). Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. Journal of General Physiology, 111(5), 653-665.
DOI Scopus137 WoS132 Europe PMC108
1998 Rychkov, G. Y., Adams, M. B., McMillen, I. C., & Roberts, M. L. (1998). Oxygen sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth. Journal of Physiology, 509(3), 887-893.
DOI Scopus44 WoS41 Europe PMC34
1998 Hryciw, D. H., Rychkov, G. Y., Hughes, B. P., & Bretag, A. H. (1998). Relevance of the D13 region to the function of the skeletal muscle chloride channel, ClC-1. Journal of Biological Chemistry, 273(8), 4304-4307.
DOI Scopus31 WoS31 Europe PMC27
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., Astill, D., Bennetts, B., & Roberts, M. (1997). pH-dependent interactions of Cd2+ and a carboxylate blocker with the rat ClC-1 chloride channel and its R304E mutant in the Sf-9 insect cell line. Journal of physiology, 501(2), 355-362.
DOI Scopus41 WoS38 Europe PMC34
1996 Astill, D. S. J., Rychkov, G., Clarke, J. D., Hughes, B. P., Roberts, M. L., & Bretag, A. H. (1996). Characteristics of skeletal muscle chloride channel ClC-1 and point mutant R304E expressed in Sf-9 insect cells. Biochimica et Biophysica Acta. Biomembranes, 1280(2), 178-186.
DOI Scopus35 WoS32 Europe PMC28
1996 Rychkov, G. Y., Pusch, M., Astill, D. S. J., Roberts, M. L., Jentsch, T. J., & Bretag, A. H. (1996). Concentration and pH dependence of skeletal muscle chloride channel ClC-1. Journal of Physiology, 497(2), 423-435.
DOI Scopus145 WoS138 Europe PMC121
1988 Ayrapetyan, S. N., Rychkov, G. Y., & Suleymanyan, M. A. (1988). Effects of water flow on transmembrane ionic currents in neurons of Helix pomatia and in squid giant axons. Comparative Biochemistry and Physiology Part A Physiology, 89(2), 179-186.
DOI Scopus20 WoS8 Europe PMC5
1988 Aǐrapetian, S. N., Rychkov, G. E., & Suleǐmanian, M. A. (1988). Modulation of calcium currents in the snail neuron membrane by osmotic gradient. Doklady Akademii Nauk SSSR, 300(4), 983-985.
Scopus2 WoS2 Europe PMC2
1988 Airapetyan, S., Rychkov, G., & Suleimanyan, M. (1988). Modulation of calcium currents in the membrane of snail neurons by means of an osmotic gradient. Doklady Biophysics, 298-300, 77-79.
1985 AIRAPETIAN, S. N., & RYCHKOV, G. E. (1985). THE AVAILABILITY OF RESERVE IONIC CHANNELS IN THE MEMBRANES OF SNAIL GIANT-NEURON AND SQUID GIANT-AXON. DOKLADY AKADEMII NAUK SSSR, 285(6), 1464-1467.
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1985 AIRAPETIAN, S. N., ZAKHARIAN, R. A., RYCHKOV, G. E., DADALIAN, S. S., BAKUNTS, I. S., & AGABALIAN, A. S. (1985). DOUBLE-STRANDED-RNA AS A STIMULATOR OF CELL PACEMAKER ACTIVITY. DOKLADY AKADEMII NAUK SSSR, 284(6), 1499-1502.
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1985 Aǐrapetian, S. N., Zakharian, R. A., Rychkov, G. E., Dadalian, S. S., & Bakunts, I. S. (1985). dsRNA as a stimulant of cell pacemaker activity. Doklady Akademii Nauk SSSR, 284(6), 1499-1502.
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1985 Aǐrapetian, S. N., & Rychkov, G. E. (1985). The presence of reserve ion channels in membranes of giant snail neurons and giant squid axons. Doklady Akademii Nauk SSSR, 285(6), 1464-1467.
Scopus4 Europe PMC1

Year Citation
2018 Rychkov, G. Y. (2018). Measurement of the CRAC Channel Fast Ca2+-Dependent Inactivation (FCDI). In A. Penna, & B. Constantin (Eds.), Methods in Molecular Biology (Vol. 1843, pp. 167-173). Humana Press.
DOI Scopus2 Europe PMC1
2017 Kozak, J., & Rychkov, G. (2017). Electrophysiological methods for recording CRAC and TRPV5/6 channels. In J. A. Kozak, & J. W. Putney Jr (Eds.), Calcium Entry Channels in Non-Excitable Cells (pp. 1-23). Boca Raton, FL; USA: CRC Press.
DOI Scopus3
2017 Ali, E., Rychkov, G., & Barritt, G. (2017). Metabolic disorders and cancer: Hepatocyte store-operated Ca(2+) channels in nonalcoholic fatty liver disease. In K. Groschner, W. Graier, & C. Romanin (Eds.), Store-Operated Ca2+ Entry (SOCE) Pathways : Emerging Signaling Concepts in Human (Patho)physiology (Vol. 993, 2nd ed., pp. 595-621). Switzerland: Springer.
DOI Scopus25 WoS23 Europe PMC20
2011 Rychkov, G., & Barritt, G. (2011). Expression and function of TRP channels in liver cells. In M. Islam (Ed.), Transient Receptor Potential Channels (Vol. 704, pp. 667-686). 233 Spring St New York NY 10013: Springer.
DOI Scopus37 WoS35 Europe PMC29

Year Citation
2018 Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., . . . Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
2018 Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
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2015 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). GC-C Agonists As Regulators of Visceral Sensation: Modulation of Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway. In GASTROENTEROLOGY Vol. 148 (pp. S732-S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C. B., Silos-Santiago, I., & Brierley, S. M. (2014). Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released in Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion (DRG) Neurons. In GASTROENTEROLOGY Vol. 146 (pp. S722). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011 Bretag, A. H., Ma, L., Rychkov, G. Y., Bykova, E. A., & Zheng, J. (2011). Using fluorescence resonance energy transfer (FRET) to reveal the basis for Thomsen's disease. In NEUROMUSCULAR DISORDERS Vol. 21 (pp. 726-727). Algarve, PORTUGAL: PERGAMON-ELSEVIER SCIENCE LTD.
DOI
2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden.
2003 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2003). Effect of G, H and I domain mutations on ClC-1 slow gating. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 483A-484A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Wu, W. P., Simpson, B., Rychkov, G., Hughes, B., & Bretag, A. (2003). Reconstitution of function in ClC-1: Coexpression of its transmembrane domain and small fragments of its carboxyl tail. In JOURNAL OF GENERAL PHYSIOLOGY Vol. 122 (pp. 12A-13A). MARINE BIOL LAB, WOODS HOLE, MASSACHUSETTS: ROCKEFELLER UNIV PRESS.
2001 Rychkov, G., Aromataris, E. C., Duffield, M., Roberts, M., & Bretag, A. H. (2001). Some Ion Channel Diseases of Muscle and their Treatment. In AOMC 2001 Interim Meeting: Mitochondrial Myopathy and other Muscle Disorders.
2001 Rychkov, G., Wu, W., Woods, A. E., Bretag, A. H., & Hughes, B. P. (2001). Visualisation of Full Length and Truncated Skeletal Muscle Chloride Channel Protein in SF9 Insect Cells. In Proceedings of the Australian Society for Biochemistry and Molecular Biology.
2001 Wu, W., Rychkov, G., Woods, A. E., Bretag, A. H., & Hughes, B. P. (2001). Visualisation of Full Length and Truncated CIC-1 Expressed in Sf9 Insect Cells. In 26th Lorne Protein Conference 2001.
2001 Rychkov, G., Aromataris, E. C., Duffield, M., Roberts, M., & Bretag, A. H. (2001). Permeation and Gating in Muscle-Type CLC Chloride Channels. In Molecular Physiology of Chloride Channels: From Melocule to Disease.
2000 Davis, B., Rychkov, G., Hughes, B. P., & Bretag, A. H. (2000). Importance of the carboxyl tail of the CIC-1 chloride channel. In proceedings of the Australian Physiological and Pharmacological Society.
2000 Bennetts, B., Roberts, M., Bretag, A. H., & Rychkov, G. (2000). Temperature dependence of CLC-1 chloride channel ating relaxations. In Proceedings of the Australian Physiological and Pharmacological Society.
2000 Aromataris, E. C., Rychkov, G., Bennetts, B., Bretag, A. H., & Roberts, M. (2000). CI- dependence of gating of myotonic mutants of the CIC-1 chloride channel. In Proceedings of the Australian Physiological and Pharmacological Society.
1998 Rychkov, G., Roberts, M., & Bretag, A. H. (1998). Modulation of gating of the sekeletal muscle chloride channel, ClC-1, by OH- and by hydrophobic anions acting from the cytoplasmic side of the channel: implications for myotonic "warm-up". In Muselce and nerve supplement 7/1998 (IX International Congress on Neuromusclar Diseases. New York: John Wiley and Sons.
1998 Hryciw, D., Rychkov, G., Hughes, B. P., & Bretag, A. H. (1998). Investigation of the function of the carboxyl terminus of the skeletal muscle chloride channel, ClC-1.. In Muscle and Nerve Supplement 7/1998 (IX International Congress on Neuromuscular Diseases). New York: John Wiley &amp; Sons.
1998 Aromataris, E. C., Rychkov, G., Hughes, B. P., Bretag, A. H., & Roberts, M. (1998). S-(-)CPP Modulates the chloride affinity of the gating site of rClC-1. In Muscle and nerve supplement 7/1998 (IX International Congress on Neuromusclar Diseases). New York: John Wiley &amp; Sons.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Relevance of the Conserved Domain D13 to the function of the skeletal muscle chloride channel, ClC-1. In Twenty-third Annual Lorne Conference on Protein Structure and Function. Australia.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., Aromataris, E. C., & Roberts, M. (1997). 2-(4-chlorophenoxy)propionate alters channel gating and current kinetics of rClC-1. In Proceedings of the Australian Physiological and Pharmacological Society.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Effects of carboxyl terminus mutations in the skeletal muscle chloride channel, ClC-1. In Proceedings of the Australian Physiological and Pharmacological Society.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Mutagenesis studies of the C-terminus of the skeletal muscle chloride channel, ClC expressed in SF9 insect cells. In Proceedings of the Australian Society for Medical Research.

Year Citation
2017 Grundy, L., Caldwell, A., Garcia-Caraballo, S., Rychkov, G., & Brierley, S. (2017). Identification of novel irritant sensing mechanisms in the bladder. Poster session presented at the meeting of Abstracts of the 112th Annual Meeting of the American Urological Association (AUA2017), as published in Journal of Urology. Boston, MA: Wolters Kluwer Health.
DOI
2017 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Ge, P., Hannig, G., . . . Brierley, S. (2017). Chronic oral administration of the guanylate cyclase-c agonist linaclotide attenuates colitis induced bladder afferent and dorsal root ganglion hyperactivity. Poster session presented at the meeting of Abstracts of the 112th Annual Meeting of the American Urological Association (AUA2017), as published in Journal of Urology. MA, Boston: Wolters Kluwer Health.
DOI
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
DOI WoS1
2012 Kilch, T., Al-Ansary, D., Rychkov, G., Peinelt, C., & Niemeyer, B. A. (2012). STIM1 Mutants Modify CRAC by Altering Orai1 Protein Concentration. Poster session presented at the meeting of BIOPHYSICAL JOURNAL. CA, San Diego: CELL PRESS.
DOI
2008 Aromataris, E. C., Castro, J., Rychkov, G. Y., & Barritt, G. J. (2008). Bile acids modulate store-operated CA2+ channels and stromal interaction molecule1 (STIM1) distribution in liver cells. Poster session presented at the meeting of Abstracts of the 43rd Annual Meeting of the European Association for the Study of the Liver, as published in Journal of Hepatology. Milan, Italy: Elsevier Science.
DOI
2008 Castro, J., Aromataris, E., Barritt, G., & Rychkov, G. (2008). Differential effects of cholestatic and choleretic bile acids on store-operated Ca2+ channels in liver [Abstract]. Poster session presented at the meeting of Abstracts of the sixty-second annual meeting of the Society of General Physiologists in Journal of General Physiology. Massachusetts, USA: Rockefeller University Press.

Year Citation
2021 Wang, B., Xu, H., Isenmann, S., Huang, C., Elorza-Vidal, X., Rychkov, G., . . . Apaja, P. (2021). Ubr1-induced selective endo-phagy/autophagy protects against the endosomal and Ca<sup>2+</sup>-induced proteostasis disease stress.
DOI
Date Project Title / No. Investigators Funding Body Amount
2015 – 2017 Novel regulation of TRP channels by oxygen-dependent hydroxylation   Peet, Rychkov and Gleadle ARC DP150102860 $364,000
2015 – 2017  The role of TRPM2 channels in oxidative stress-induced liver damage Rychkov, Barritt and Burt NHMRC APP1086817 $556,000
2014 – 2016 Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins
Rychkov and Barritt  
University of Adelaide, B3 Establishment Grant $390,000
2011 – 2013 Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity Brierley, Blackshaw and Rychkov NHMRC Project Grant $436,000
2008 Patch clamping and imaging cells in tissue slices Rychkov, Koblar, Gronthos, Kumar, Blackshaw, Brierley, Wilson, Beltrame and Peet NHMRC Equipment Grant $75,000
2008 - 2010 Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents Blackshaw, Brierley, Rychkov and Holtmann NHMRC Project Grant $641,000
2008 - 2010 STIM1 and Orai1 proteins in store-operated Ca2+ entry in liver Rychkov,  Barritt and Wilson NHMRC Project Grant $346,000
2007 – 2011   Rychkov NHMRC Senior Research Fellowship $537,500
2005 - 2007 Activation mechanisms of store-operated calcium channels in liver cells Rychkov and Barritt ARC Discovery Project $264,917
2002 - 2004 Store-operated calcium channels and liver function Rychkov, Barritt and Roberts NHMRC Project Grant $242,785
2002 - 2006 Regulatory mechanisms for calcium release-activated calcium channels Rychkov, Barritt, and Roberts ARC Discovery Project and Australian Research Fellowship $507,499
2002   Rychkov University of Adelaide, B3 Establishment Grant $11,000
2001 Towards chloride channel purification and rational treatment for myotonic muscle stiffness. Bretag, Rychkov ATN Small Grant $17,000
2000 Regulation of calcium sensitivity of exocytosis - novel function for the sulphonyrea receptor. Roberts, Rychkov ARC Small Grant $10,000
Date Course Title Role
2013                     Cellular & Systems Neurobiology Co-ordinator
2011 - 2013 Peripheral Sensory Functions Lecturer
2011 - 2013 Reflexes and Reflex testing Lecturer
2011 - 2013 Skin Physiology Lecturer
2011 - 2013 Ion channels and G-protein coupled receptors Lecturer
2011 - 2013 Cardiovascular Physiology and ANS Supervised practical
1995 - present  3rd year Research Projects of Biomedical Science and Physiology Science students Supervisor
1989 - 1991 Biophysics Lecturer
1989 - 1991 Introduction to molecular endocrinology Lecturer
1989 - 1991 Biomechanics Lecturer

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2022 Co-Supervisor The Role of Itch-Mediating Receptors and Channels in the Mouse Urinary Bladder Doctor of Philosophy Doctorate Full Time Ashlee Megan Caldwell
2015 - 2019 Co-Supervisor Role of Voltage-gated Sodium Channel Isoforms in Electrophysiological Properties of Neurons Innervating the Viscera in Mice Doctor of Philosophy Doctorate Full Time Ms Andelain Erickson
2010 - 2011 Co-Supervisor Statin mediated vasodilation in the vaculature Doctor of Philosophy Doctorate Full Time Mr Scott Copley
2010 - 2012 Principal Supervisor The Role of Stim and Orai Proteins in the CalCium Release-Activated CalCium Channel Doctor of Philosophy Doctorate Full Time Mr Nathan Scrimgeour
2010 - 2015 Principal Supervisor The role of TRPM2 channels in oxidative stress-induced liver damage Doctor of Philosophy Doctorate Part Time Mr Ehsan Kheradpezhouh
2009 - 2009 Principal Supervisor Pharmacology of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time APrf Edoardo Aromataris
2000 - 2005 Co-Supervisor Gating of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Michael Duffield
1998 - 2003 Co-Supervisor OXYGEN SENSING IN THE SHEEP ADRENAL MEDULLA Doctor of Philosophy Doctorate Part Time Mr Damien Keating
1997 - 2008 Co-Supervisor Structure Function Studies of Muscle-type CIC Chloride Channels Doctor of Philosophy Doctorate Part Time Mr Brett Bennetts

Date Role Committee Institution Country
2010 - 2013 Member School of Medical Sciences HDR Committee - Australia
2008 - ongoing Member Medical and Scientific Research Advisory Committee of Muscular Dystrophy Association Muscular Dystrophy Association Australia
2007 - ongoing Member AuPS advisory committee on Cell Signalling - Australia
1996 - ongoing Chair South Australian Facility for Patch Clamping and Confocal Microscopy University of Adelaide Australia

Date Role Membership Country
2007 - 2012 Member National Association of Research Fellows Australia
2003 - ongoing Member Society for General Physiologists Australia
1994 - ongoing Member Member of the Australian Physiological Society Australia

Date Office Name Institution Country
2014 - ongoing Postgraduate Coordinator South Australian Health and Medical Research Institute Australia

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