Grigori Rychkov

Grigori Rychkov

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Liver Metabolism Group - Group Leader

This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.

Current Research Projects

1. The role of Store-operated Ca2+ channels in Ca2+ signalling
2. The role of TRP channels in liver physiology and pathology (with Prof Barritt)  
3. The role of TRP channels in mechanosensation in the gut (with Dr Brierley)
4. Mechanisms of oxygen sensitivity of TRPV3 channel (with Dr Peet)
5. Regulation of Na+ channels in lung epithelia (with Prof Kumar)
6. Differentiation of adult human dental pulp stem cells into functionally active neurons (with A/Prof Koblar and Prof Gronthos)

  • Appointments

    Date Position Institution name
    2014 - ongoing University Senior Research Fellow (Level D) University of Adelaide
    2013 - ongoing University Senior Research Fellow (Level D) University of Adelaide
    2010 - 2012 NHMRC Senior Research Fellow (Level D) University of Adelaide
    2007 - 2009 NHMRC Senior Research Fellow (Level C) University of Adelaide
    2002 - 2010 Visiting Senior Lecturer University of Adelaide
    2002 - 2006 Australian Research Fellow University of Adelaide
    1999 - 2001 Senior Research Associate University of South Australia
    1994 - 1998 Research Associate University of South Australia
    1990 - 1991 Lecturer Abkhazian State University
    1988 - 1992 Research Associate USSR Medical Academy
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2007 Fellowship NHMRC Senior Research Fellowship National Health and Medical Research Council Australia -
    2002 Fellowship Australian Research Council Research Fellowship Australian Research Council Australia -
    2002 Achievement Adjunct Senior Lecturer University of South Australia Australia -
    1984 Scholarship Armenian Academy of Science Postgraduate Scholarship Armenian Academy of Science Armenia -
  • Education

    Date Institution name Country Title
    1985 - 1987 Institute of Experimental Biology, Armenian Academy of Science Armenia, USSR PhD in Biological Sciences (Biophysics)
    1979 - 1983 Rostov-on-Don State University Russia Bachelor of Science, Honours (Physics) and Bachelor of Education
  • Research Interests

Date Project Title / No. Investigators Funding Body Amount
2015 – 2017 Novel regulation of TRP channels by oxygen-dependent hydroxylation   Peet, Rychkov and Gleadle ARC DP150102860 $364,000
2015 – 2017  The role of TRPM2 channels in oxidative stress-induced liver damage Rychkov, Barritt and Burt NHMRC APP1086817 $556,000
2014 – 2016 Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins
Rychkov and Barritt  
University of Adelaide, B3 Establishment Grant $390,000
2011 – 2013 Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity Brierley, Blackshaw and Rychkov NHMRC Project Grant $436,000
2008 Patch clamping and imaging cells in tissue slices Rychkov, Koblar, Gronthos, Kumar, Blackshaw, Brierley, Wilson, Beltrame and Peet NHMRC Equipment Grant $75,000
2008 - 2010 Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents Blackshaw, Brierley, Rychkov and Holtmann NHMRC Project Grant $641,000
2008 - 2010 STIM1 and Orai1 proteins in store-operated Ca2+ entry in liver Rychkov,  Barritt and Wilson NHMRC Project Grant $346,000
2007 – 2011   Rychkov NHMRC Senior Research Fellowship $537,500
2005 - 2007 Activation mechanisms of store-operated calcium channels in liver cells Rychkov and Barritt ARC Discovery Project $264,917
2002 - 2004 Store-operated calcium channels and liver function Rychkov, Barritt and Roberts NHMRC Project Grant $242,785
2002 - 2006 Regulatory mechanisms for calcium release-activated calcium channels Rychkov, Barritt, and Roberts ARC Discovery Project and Australian Research Fellowship $507,499
2002   Rychkov University of Adelaide, B3 Establishment Grant $11,000
2001 Towards chloride channel purification and rational treatment for myotonic muscle stiffness. Bretag, Rychkov ATN Small Grant $17,000
2000 Regulation of calcium sensitivity of exocytosis - novel function for the sulphonyrea receptor. Roberts, Rychkov ARC Small Grant $10,000
Date Course Title Role
2013                     Cellular & Systems Neurobiology Co-ordinator
2011 - 2013 Peripheral Sensory Functions Lecturer
2011 - 2013 Reflexes and Reflex testing Lecturer
2011 - 2013 Skin Physiology Lecturer
2011 - 2013 Ion channels and G-protein coupled receptors Lecturer
2011 - 2013 Cardiovascular Physiology and ANS Supervised practical
1995 - present  3rd year Research Projects of Biomedical Science and Physiology Science students Supervisor
1989 - 1991 Biophysics Lecturer
1989 - 1991 Introduction to molecular endocrinology Lecturer
1989 - 1991 Biomechanics Lecturer
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2016 - 2022 Co-Supervisor The Role of Itch-Mediating Receptors and Channels in the Mouse Urinary Bladder Doctor of Philosophy Doctorate Full Time Ashlee Megan Caldwell
    2015 - 2019 Co-Supervisor Role of Voltage-gated Sodium Channel Isoforms in Electrophysiological Properties of Neurons Innervating the Viscera in Mice Doctor of Philosophy Doctorate Full Time Ms Andelain Erickson
    2010 - 2011 Co-Supervisor Statin mediated vasodilation in the vaculature Doctor of Philosophy Doctorate Full Time Mr Scott Copley
    2010 - 2012 Principal Supervisor The Role of Stim and Orai Proteins in the CalCium Release-Activated CalCium Channel Doctor of Philosophy Doctorate Full Time Mr Nathan Scrimgeour
    2010 - 2015 Principal Supervisor The role of TRPM2 channels in oxidative stress-induced liver damage Doctor of Philosophy Doctorate Part Time Mr Ehsan Kheradpezhouh
    2009 - 2009 Principal Supervisor Pharmacology of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time APrf Edoardo Aromataris
    2000 - 2005 Co-Supervisor Gating of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Michael Duffield
    1998 - 2003 Co-Supervisor OXYGEN SENSING IN THE SHEEP ADRENAL MEDULLA Doctor of Philosophy Doctorate Part Time Mr Damien Keating
    1997 - 2008 Co-Supervisor Structure Function Studies of Muscle-type CIC Chloride Channels Doctor of Philosophy Doctorate Part Time Mr Brett Bennetts
  • Committee Memberships

    Date Role Committee Institution Country
    2010 - 2013 Member School of Medical Sciences HDR Committee - Australia
    2008 - ongoing Member Medical and Scientific Research Advisory Committee of Muscular Dystrophy Association Muscular Dystrophy Association Australia
    2007 - ongoing Member AuPS advisory committee on Cell Signalling - Australia
    1996 - ongoing Chair South Australian Facility for Patch Clamping and Confocal Microscopy University of Adelaide Australia
  • Memberships

    Date Role Membership Country
    2007 - 2012 Member National Association of Research Fellows Australia
    2003 - ongoing Member Society for General Physiologists Australia
    1994 - ongoing Member Member of the Australian Physiological Society Australia
  • Offices Held

    Date Office Name Institution Country
    2014 - ongoing Postgraduate Coordinator South Australian Health and Medical Research Institute Australia

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