Associate Professor Grigori Rychkov

Grigori Rychkov
University Senior Research Fellow - D
Adelaide Medical School
Faculty of Health and Medical Sciences

Liver Metabolism Group - Group Leader

This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.

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External Profiles

Associate Professor Grigori Rychkov

Liver Metabolism Group - Group Leader

This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

Current Research Projects

1. The role of Store-operated Ca2+ channels in Ca2+ signalling
2. The role of TRP channels in liver physiology and pathology (with Prof Barritt)  
3. The role of TRP channels in mechanosensation in the gut (with Dr Brierley)
4. Mechanisms of oxygen sensitivity of TRPV3 channel (with Dr Peet)
5. Regulation of Na+ channels in lung epithelia (with Prof Kumar)
6. Differentiation of adult human dental pulp stem cells into functionally active neurons (with A/Prof Koblar and Prof Gronthos)

Appointments

Date Position Institution name
2014 University Senior Research Fellow (Level D) University of Adelaide
2013 University Senior Research Fellow (Level D) University of Adelaide
2010 - 2012 NHMRC Senior Research Fellow (Level D) University of Adelaide
2007 - 2009 NHMRC Senior Research Fellow (Level C) University of Adelaide
2002 - 2010 Visiting Senior Lecturer University of Adelaide
2002 - 2006 Australian Research Fellow University of Adelaide
1999 - 2001 Senior Research Associate University of South Australia
1994 - 1998 Research Associate University of South Australia
1990 - 1991 Lecturer Abkhazian State University
1988 - 1992 Research Associate USSR Medical Academy

Awards and Achievements

Date Type Title Institution Name Country Amount
2007 Fellowship NHMRC Senior Research Fellowship National Health and Medical Research Council Australia
2002 Fellowship Australian Research Council Research Fellowship Australian Research Council Australia
2002 Achievement Adjunct Senior Lecturer University of South Australia Australia
1984 Scholarship Armenian Academy of Science Postgraduate Scholarship Armenian Academy of Science Armenia

Education

Date Institution name Country Title
1985 - 1987 Institute of Experimental Biology, Armenian Academy of Science Armenia, USSR PhD in Biological Sciences (Biophysics)
1979 - 1983 Rostov-on-Don State University Russia Bachelor of Science, Honours (Physics) and Bachelor of Education

Research Interests

Journals

Year Citation
2017 Gavriliouk, D., Scrimgeour, N., Grigoryev, S., Ma, L., Zhou, F., Barritt, G., & Rychkov, G. (2017). Regulation of Orai1/STIM1 mediated I<inf>CRAC</inf> by intracellular pH. Scientific Reports, 7(1), 12 pages.
DOI
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A., . . . Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7, 42810-1-42810-19.
DOI Scopus6 WoS2 Europe PMC5
2017 Nagarajan, Y., Rychkov, G., & Peet, D. (2017). Modulation of TRP channel activity by hydroxylation and its therapeutic potential. Pharmaceuticals, 10(2), 35.
DOI Scopus2 Europe PMC1
2017 Castro, J., Grundy, L., Deiteren, A., Harrington, A. M., O'Donnell, T., Maddern, J., . . . Brierley, S. M. (2017). Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.. British journal of pharmacology.
DOI
2016 Kheradpezhouh, E., Barritt, G., & Rychkov, G. (2016). Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. Redox Biology, 7, 1-7.
DOI Scopus10 WoS12 Europe PMC8
2016 Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X., . . . Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534(7608), 494-499.
DOI Scopus34 WoS36 Europe PMC30
2016 Zhang, W., Garg, S., Eldi, P., Zhou, F., Johnson, I., Brooks, D., . . . Albrecht, H. (2016). Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide. International Journal of Pharmaceutics, 513(1-2), 270-279.
DOI Scopus4 WoS4 Europe PMC1
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C., . . . Brierley, S. (2016). Chronic oral administration of the guanylate cyclase-C agonist linaclotide attenuates colitis induced bladder afferent hyperactivity. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 29.
2016 Ali, E., Hua, J., Wilson, C., Tallis, G., Zhou, F., Rychkov, G., & Barritt, G. (2016). The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca²⁺ signalling in steatotic hepatocytes. Biochimica et Biophysica Acta-Molecular Cell Research, 1863(9), 2135-2146.
DOI Scopus3 WoS2 Europe PMC2
2015 Karttunen, S., Duffield, M., Scrimgeour, N., Squires, L., Lim, W., Dallas, M., . . . Peet, D. (2015). Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. Journal of Cell Science, 128(2), 225-231.
DOI Scopus11 WoS12 Europe PMC11
2015 Wilson, C., Ali, E., Scrimgeour, N., Martin, A., Hua, J., Tallis, G., . . . Barritt, G. (2015). Steatosis inhibits liver cell store-operated Ca<sup>2+</sup> entry and reduces ER Ca<sup>2+</sup> through a protein kinase C-dependent mechanism. Biochemical Journal, 466(2), 379-390.
DOI Scopus6 WoS6 Europe PMC3
2014 Ekberg, J., Boase, N., Rychkov, G., Manning, J., Poronnik, P., & Kumar, S. (2014). Nedd4-2 (NEDD4L) controls intracellular Na⁺ -mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochemical Journal, 457(1), 27-31.
DOI Scopus13 WoS13 Europe PMC9
2014 Ellis, K., O'Carroll, D., Lewis, M., Rychkov, G., & Koblar, S. (2014). Neurogenic potential of dental pulp stem cells isolated from murine incisors. Stem Cell Research and Therapy, 5(1), 30-1-30-13.
DOI Scopus23 WoS16 Europe PMC17
2014 Kheradpezhouh, E., Ma, L., Morphett, A., Barritt, G., & Rychkov, G. (2014). TRPM2 channels mediate acetaminophen-induced liver damage. Proceedings of the National Academy of Sciences of the United States of America, 111(8), 3176-3181.
DOI Scopus33 WoS33 Europe PMC26
2014 Scrimgeour, N., Wilson, D., Barritt, G., & Rychkov, G. (2014). Structural and stoichiometric determinants of Ca<sup>2 +</sup> release-activated Ca<sup>2 +</sup> (CRAC) channel Ca<sup>2 +</sup>-dependent inactivation. Biochimica et Biophysica Acta - Biomembranes, 1838(5), 1281-1287.
DOI Scopus5 WoS2 Europe PMC1
2013 Kilch, T., Alansary, D., Peglow, M., Dorr, K., Rychkov, G., Rieger, H., . . . Niemeyer, B. (2013). Mutations of the ca²⁺-sensing stromal interaction molecule stim1 regulate ca²⁺ influx by altered oligomerization of stim1 and by destabilization of the ca²⁺ channel orai1. Journal of Biological Chemistry, 288(3), 1653-1664.
DOI Scopus30 WoS27 Europe PMC20
2012 Scrimgeour, N., Wilson, D., & Rychkov, G. (2012). Glu(106) in the Orai1 pore contributes to fast Ca(2+)-dependent inactivation and pH dependence of Ca(2+) release-activated Ca(2+) (CRAC) current. Biochemical Journal, 441(2), 743-753.
DOI Scopus21 WoS21 Europe PMC17
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593.
DOI Scopus67 WoS59 Europe PMC38
2011 Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G., & Rychkov, G. (2011). The predominant role of IP₃ type 1 receptors in activation of store-operated Ca²⁺ entry in liver cells. Biochimica et Biophysica Acta-Biomembranes, 1808(3), 745-751.
DOI Scopus2 WoS2 Europe PMC1
2011 Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., . . . Cook, D. (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9.
DOI Scopus49 WoS45 Europe PMC40
2011 Ma, L., Rychkov, G., Bykova, E., Zheng, J., & Bretag, A. (2011). Movement of hCIC-1 C-termini during common gating and limits on their cytoplasmic location. Biochemical Journal, 436(2), 415-428.
DOI Scopus18 WoS17 Europe PMC14
2011 Rychkov, G., & Barritt, G. (2011). Expression and function of TRP channels in liver cells. Advances in Experimental Medicine and Biology, 704, 1-20.
DOI
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G., & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3(9), 2768-2798.
DOI Scopus6 Europe PMC2
2010 To, M., Aromataris, E., Castro, J., Roberts, M., Barritt, G., & Rychkov, G. (2010). Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca2+ current in liver cells. Archives of Biochemistry and Biophysics, 495(2), 152-158.
DOI Scopus20 WoS15 Europe PMC12
2010 Cederholm, J., Rychkov, G., Bagley, C., & Bretag, A. (2010). Inter-subunit communication and fast gate integrity are important for common gating in hCIC-1. International Journal of Biochemistry & Cell Biology, 42(7), 1182-1188.
DOI Scopus19 WoS18 Europe PMC17
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095.
DOI Scopus152 WoS138 Europe PMC106
2009 Keating, D., Rychkov, G., & Roberts, M. (2009). The contribution of voltage-gated Ca²⁺ currents to K⁺ channel activation during ovine adrenal chromaffin cell development. International Journal of Developmental Neuroscience, 27(4), 357-363.
DOI Scopus3 WoS3 Europe PMC2
2009 Scrimgeour, N., Litjens, T., Ma, L., Barritt, G., & Rychkov, G. (2009). Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. Journal of Physiology-London, 587(12), 2903-2918.
DOI Scopus74 WoS56 Europe PMC48
2009 Ma, L., Rychkov, G., & Bretag, A. (2009). Functional study of cytoplasmic loops of human skeletal muscle chloride channel, hClC-1. International Journal of Biochemistry & Cell Biology, 41(6), 1402-1409.
DOI Scopus3 WoS3 Europe PMC3
2009 Castro, J., Aromataris, E., Rychkov, G., & Barritt, G. (2009). A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. Biochemical Journal, 418(Part 3), 553-566.
DOI Scopus17 WoS14 Europe PMC9
2009 Barritt, G., Litjens, T., Castro, J., Aromataris, E., & Rychkov, G. (2009). Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells. Clinical and Experimental Pharmacology and Physiology, 36(1), 77-83.
DOI Scopus14 WoS12 Europe PMC8
2008 Arthur, A., Rychkov, G., Shi, S., Koblar, S., & Gronthos, S. (2008). Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells, 26(7), 1787-1795.
DOI Scopus287 WoS273 Europe PMC203
2008 Ma, L., Rychkov, G., Hughes, B., & Bretag, A. (2008). Analysis of carboxyl tail function in the skeletal muscle Cl⁻ channel hClC-1. Biochemical Journal, 413 Part 1(1), 61-69.
DOI Scopus4 WoS3 Europe PMC4
2008 Aromataris, E., Castro, J., Rychkov, G., & Barritt, G. (2008). Store-operated Ca2+ channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(5), 874-885.
DOI Scopus21 WoS18 Europe PMC10
2008 Barritt, G., Chen, J., & Rychkov, G. (2008). Ca²⁺-permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(5), 651-672.
DOI Scopus36 WoS30 Europe PMC19
2007 Rychkov, G., & Barritt, G. (2007). TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of Experimental Pharmacology, 179(179), 23-52.
DOI Scopus58 Europe PMC18
2007 Litjens, T., Nguyen, T., Castro Kraftchenko, J., Aromataris, E., Jones, L., Barritt, G., & Rychkov, G. (2007). Phospholipase C-γ1 is required for the activation of store-operated Ca²⁺ channels in liver cells. Biochemical Journal, 405(2), 269-276.
DOI Scopus29 WoS25 Europe PMC20
2006 Aromataris, E., & Rychkov, G. (2006). ClC-1 chloride channel: Matching its properties to a role in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 33(11), 1118-1123.
DOI Scopus14 WoS16 Europe PMC15
2006 Aromataris, E., Roberts, M., Barritt, G., & Rychkov, G. (2006). Glucagon activates Ca2+ and Cl- channels in rat hepatocytes. Journal of Physiology-London, 573(3), 611-625.
DOI Scopus44 WoS38 Europe PMC31
2006 Wu, W., Rychkov, G., Hughes, B., & Bretag, A. (2006). Functional complementation of truncated human skeletal-muscle chloride channel (hCIC-1) using carboxyl tail fragments. Biochemical Journal, 395(1), 89-97.
DOI Scopus12 Europe PMC11
2005 Barritt, G., & Rychkov, G. (2005). TRPs as mechanosensitive channels. Nature Cell Biology, 7(2), 105-107.
DOI Scopus30 WoS28 Europe PMC15
2005 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2005). Zinc inhibits human CIC-1 muscle chloride channel by interacting with its common gating mechanism. Journal of Physiology-London, 568(1), 5-12.
DOI Scopus20 Europe PMC13
2005 Keating, D., Rychkov, G., Giacomin, P., & Roberts, M. (2005). Oxygen-sensing pathway for SK channels in the ovine adrenal medulla. Clinical and Experimental Pharmacology and Physiology, 32(10), 882-887.
DOI Scopus19 Europe PMC15
2005 Bennetts, B., Rychkov, G., Ng, H., Morton, C., Stapleton, D., Parker, M., & Cromer, B. (2005). Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. Journal of Biological Chemistry, 280(37), 32452-32458.
DOI Scopus91 Europe PMC72
2005 Rychkov, G., Litjens, T., Roberts, M., & Barritt, G. (2005). ATP and vasopressin activate a single type of store-operated Ca2+ channel, identified by patch-clamp recording, in rat hepatocytes. Cell Calcium, 37(2), 183-191.
DOI Scopus25 Europe PMC21
2005 Rychkov, G., Litjens, T., Roberts, M., & Barritt, G. (2005). Arachidonic acid inhibits the store-operated Ca2+ current in rat liver cells. Biochemical Journal, 385(2), 551-556.
DOI Scopus23 Europe PMC16
2004 Litjens, T., Harland, M., Roberts, M., Barritt, G., & Rychkov, G. (2004). Fast Ca2+-dependent inactivation of the store operated Ca2+ current (ISOC) in liver cells: a role for calmodulin. Journal of Physiology-London, 558(1), 85-97.
DOI Scopus44 Europe PMC32
2004 Simpson, B., Height, T., Rychkov, G., Nowak, K., Laing, N., Hughes, B., & Bretag, A. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression. Human Mutation, 731(2), 1-7.
DOI Europe PMC11
2004 Keating, D., Rychkov, G., Adams, M., Holgert, H., McMillen, I., & Roberts, M. (2004). Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels. Journal of Physiology-London, 555(2), 489-502.
DOI Scopus15 Europe PMC13
2004 Simpson, B., Height, T., Rychkov, G., Nowak, K., Laing, N., Hughes, B., & Bretag, A. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression.. Human mutation, 24(2), 185.
Scopus21
2003 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2003). Involvement of helices at the dimer interface in C1C-1 common gating. Journal of General Physiology, 121(2), 149-161.
DOI Scopus81 WoS78 Europe PMC57
2001 Aromataris, E., Rychkov, G., Bennetts, B., Hughes, B., Bretag, A., & Roberts, M. (2001). Fast and slow gating of CLC-1: Differential effects of 2-(4-chlorophenoxy) propionic acid and dominant negative mutations. Molecular Pharmacology, 60(1), 200-208.
DOI Scopus25 WoS23 Europe PMC14
2001 Bennetts, B., Roberts, M., Bretag, A., & Rychkov, G. (2001). Temperature dependence of human muscle ClC-1 chloride channel. Journal of Physiology-London, 535(1), 83-93.
DOI Scopus42
2001 Rychkov, G., Pusch, M., Roberts, M., & Bretag, A. (2001). Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating. Journal of Physiology-London, 530(3), 379-393.
DOI Scopus25
2001 Rychkov, G., Brereton, H., Harland, M., & Barritt, G. (2001). Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells. Hepatology, 33(4), 938-947.
DOI Scopus57 WoS52 Europe PMC45
2001 Brereton, H., Chen, J., Rychkov, G., Harland, M., & Barritt, G. (2001). Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1540(2), 107-126.
DOI Scopus39 WoS36 Europe PMC30
2001 Gregory, R., Rychkov, G., & Barritt, G. (2001). Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochemical Journal, 354(2), 285-290.
DOI WoS149 Europe PMC90
2001 Keating, D., Rychkov, G., & Roberts, M. (2001). Oxygen sensitivity in the sheep adrenal medulla: role of SK channels. American Journal of Physiology-Cell Physiology, 281(5), C1434-C1441.
DOI Scopus40 Europe PMC17
2001 Bennetts, B., Roberts, M., Bretag, A., & Rychkov, G. (2001). Temperature dependence of human muscle ClC-1 chloride channel.. The Journal of physiology, 535(Pt 1), 83-93.
DOI Europe PMC28
2001 Rychkov, G., Pusch, M., Roberts, M., & Bretag, A. (2001). Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating.. The Journal of physiology, 530(Pt 3), 379-393.
DOI Europe PMC14
2001 GREGORY, R. B., RYCHKOV, G., & BARRITT, G. J. (2001). Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochemical Journal, 354(2), 285.
DOI
1999 Aromataris, E., Astill, D., Rychkov, G., Bryant, S., Bretag, A., & Roberts, M. (1999). Modulation of the gating of CIC-1 by S-(--) 2-(4-chlorophenoxy) propionic acid. British Journal of Pharmacology, 126(6), 1375-1382.
DOI Scopus31 WoS29 Europe PMC21
1998 Rychkov, G., Pusch, M., Roberts, M., Jentsch, T., & Bretag, A. (1998). Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. Journal of General Physiology, 111(5), 653-665.
DOI Scopus112 Europe PMC82
1998 Rychkov, G., Adams, M., McMillen, I., & Roberts, M. (1998). Oxygen sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth. Journal of Physiology, 509(3), 887-893.
DOI Scopus38 Europe PMC27
1998 Hryciw, D., Rychkov, G., Hughes, B., & Bretag, A. (1998). Relevance of the D13 region to the function of the skeletal muscle chloride channel, ClC-1. Journal of Biological Chemistry, 273(8), 4304-4307.
DOI Scopus28 Europe PMC20
1997 Rychkov, G., Astill, D., Bennetts, B., Hughes, B., Bretag, A., & Roberts, M. (1997). pH-dependent interactions of Cd2+ and a carboxylate blocker with the rat ClC-1 chloride channel and its R304E mutant in the Sf-9 insect cell line. Journal of Physiology, 501(2), 355-362.
DOI Scopus37 Europe PMC25
1996 Rychkov, G., Pusch, M., Astill, D., Roberts, M., Jentsch, T., & Bretag, A. (1996). Concentration and pH dependence of skeletal muscle chloride channel ClC-1.. The Journal of physiology, 497 ( Pt 2)(2), 423-435.
DOI Europe PMC89
1996 Astill, D., Rychkov, G., Clarke, J., Hughes, B., Roberts, M., & Bretag, A. (1996). Characteristics of skeletal muscle chloride channel ClC-1 and point mutant R304E expressed in Sf-9 insect cells. Biochimica et Biophysica Acta - Biomembranes, 1280(2), 178-186.
DOI Scopus27 WoS28 Europe PMC19
1988 Ayrapetyan, S., Rychkov, G., & Suleymanyan, M. (1988). Effects of water flow on transmembrane ionic currents in neurons of Helix pomatia and in squid giant axons.. Comparative biochemistry and physiology. A, Comparative physiology, 89(2), 179-186.
DOI Europe PMC4
1988 Aĭrapetian, S., Rychkov, G., & Suleĭmanian, M. (1988). [Modulation of calcium currents in the snail neuron membrane by osmotic gradient]. Doklady Akademii nauk SSSR, 300(4), 983-985.
Europe PMC1
1985 Aĭrapetian, S., Zakharian, R., Rychkov, G., Dadalian, S., & Bakunts, I. (1985). [dsRNA as a stimulant of cell pacemaker activity]. Doklady Akademii nauk SSSR, 284(6), 1499-1502.
1985 Aĭrapetian, S., & Rychkov, G. (1985). [The presence of reserve ion channels in membranes of giant snail neurons and giant squid axons]. Doklady Akademii nauk SSSR, 285(6), 1464-1467.

Book Chapters

Year Citation
2017 Ali, E., Rychkov, G., & Barritt, G. (2017). Metabolic disorders and cancer: Hepatocyte store-operated Ca<sup>2+</sup> channels in nonalcoholic fatty liver disease. In K. Groschner, W. Graier, & C. Romanin (Eds.), Store-Operated Ca2+ Entry (SOCE) Pathways : Emerging Signaling Concepts in Human (Patho)physiology (Vol. 993, 2nd ed., pp. 595-621). Switzerland: Springer.
DOI
2011 Rychkov, G., & Barritt, G. (2011). Expression and function of TRP channels in liver cells. In M. Islam (Ed.), Transient Receptor Potential Channels (Vol. 704, pp. 667-686). 233 Spring St New York NY 10013: Springer.
DOI Scopus17 WoS15 Europe PMC11

Conference Papers

Year Citation
2011 Bretag, A. H., Ma, L., Rychkov, G. Y., Bykova, E. A., & Zheng, J. (2011). Using fluorescence resonance energy transfer (FRET) to reveal the basis for Thomsen's disease. In NEUROMUSCULAR DISORDERS Vol. 21 (pp. 726-727). Algarve, PORTUGAL: PERGAMON-ELSEVIER SCIENCE LTD.
DOI
2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76 (0 pages)). Stockholm, Sweden.
2003 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2003). Effect of G, H and I domain mutations on ClC-1 slow gating. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 483A-484A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Wu, W., Simpson, B., Rychkov, G., Hughes, B., & Bretag, A. (2003). Reconstitution of function in ClC-1: Coexpression of its transmembrane domain and small fragments of its carboxyl tail. In JOURNAL OF GENERAL PHYSIOLOGY Vol. 122 (pp. 12A-13A). MARINE BIOL LAB, WOODS HOLE, MASSACHUSETTS: ROCKEFELLER UNIV PRESS.

Conference Items

Year Citation
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
DOI WoS1
2012 Kilch, T., Al-Ansary, D., Rychkov, G., Peinelt, C., & Niemeyer, B. A. (2012). STIM1 Mutants Modify CRAC by Altering Orai1 Protein Concentration. Poster session presented at the meeting of BIOPHYSICAL JOURNAL. San Diego, CA: CELL PRESS.
DOI
2008 Castro, J., Aromataris, E., Barritt, G., & Rychkov, G. (2008). Differential effects of cholestatic and choleretic bile acids on store-operated Ca2+ channels in liver [Abstract]. Poster session presented at the meeting of Abstracts of the sixty-second annual meeting of the Society of General Physiologists in Journal of General Physiology. Massachusetts, USA: Rockefeller University Press.
2008 Aromataris, E. C., Castro, J., Rychkov, G. Y., & Barritt, G. J. (2008). Bile acids modulate store-operated CA2+ channels and stromal interaction molecule1 (STIM1) distribution in liver cells. Poster session presented at the meeting of Abstracts of the 43rd Annual Meeting of the European Association for the Study of the Liver, as published in Journal of Hepatology. Milan, Italy: Elsevier Science.
DOI
Date Project Title / No. Investigators Funding Body Amount
2015 – 2017 Novel regulation of TRP channels by oxygen-dependent hydroxylation   Peet, Rychkov and Gleadle ARC DP150102860 $364,000
2015 – 2017  The role of TRPM2 channels in oxidative stress-induced liver damage Rychkov, Barritt and Burt NHMRC APP1086817 $556,000
2014 – 2016 Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins
Rychkov and Barritt  
University of Adelaide, B3 Establishment Grant $390,000
2011 – 2013 Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity Brierley, Blackshaw and Rychkov NHMRC Project Grant $436,000
2008 Patch clamping and imaging cells in tissue slices Rychkov, Koblar, Gronthos, Kumar, Blackshaw, Brierley, Wilson, Beltrame and Peet NHMRC Equipment Grant $75,000
2008 - 2010 Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents Blackshaw, Brierley, Rychkov and Holtmann NHMRC Project Grant $641,000
2008 - 2010 STIM1 and Orai1 proteins in store-operated Ca2+ entry in liver Rychkov,  Barritt and Wilson NHMRC Project Grant $346,000
2007 – 2011   Rychkov NHMRC Senior Research Fellowship $537,500
2005 - 2007 Activation mechanisms of store-operated calcium channels in liver cells Rychkov and Barritt ARC Discovery Project $264,917
2002 - 2004 Store-operated calcium channels and liver function Rychkov, Barritt and Roberts NHMRC Project Grant $242,785
2002 - 2006 Regulatory mechanisms for calcium release-activated calcium channels Rychkov, Barritt, and Roberts ARC Discovery Project and Australian Research Fellowship $507,499
2002   Rychkov University of Adelaide, B3 Establishment Grant $11,000
2001 Towards chloride channel purification and rational treatment for myotonic muscle stiffness. Bretag, Rychkov ATN Small Grant $17,000
2000 Regulation of calcium sensitivity of exocytosis - novel function for the sulphonyrea receptor. Roberts, Rychkov ARC Small Grant $10,000
Date Course Title Role
2013                     Cellular & Systems Neurobiology Co-ordinator
2011 - 2013 Peripheral Sensory Functions Lecturer
2011 - 2013 Reflexes and Reflex testing Lecturer
2011 - 2013 Skin Physiology Lecturer
2011 - 2013 Ion channels and G-protein coupled receptors Lecturer
2011 - 2013 Cardiovascular Physiology and ANS Supervised practical
1995 - present  3rd year Research Projects of Biomedical Science and Physiology Science students Supervisor
1989 - 1991 Biophysics Lecturer
1989 - 1991 Introduction to molecular endocrinology Lecturer
1989 - 1991 Biomechanics Lecturer

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2016 Co-Supervisor The Role of Itch-Mediating Channels and Receptors in the Urinary Bladder during Health and Hypersensitivity Doctor of Philosophy Doctorate Full Time Ashlee Megan Caldwell
2015 Co-Supervisor Investigation of Colonic Voltage- gated Sodium Channel Function and Expression in Inflammatory and Chronic Visceral Pain States Doctor of Philosophy Doctorate Full Time Ms Andelain Erickson

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2010 - 2011 Co-Supervisor Statin mediated vasodilation in the vaculature Doctor of Philosophy Doctorate Full Time Mr Scott Copley
2010 - 2012 Principal Supervisor The Role of Stim and Orai Proteins in the CalCium Release-Activated CalCium Channel Doctor of Philosophy Doctorate Full Time Mr Nathan Scrimgeour
2010 - 2015 Principal Supervisor The role of TRPM2 channels in oxidative stress-induced liver damage Doctor of Philosophy Doctorate Part Time Mr Ehsan Kheradpezhouh
2009 - 2009 Principal Supervisor Pharmacology of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Edoardo Aromataris
2000 - 2005 Co-Supervisor Gating of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Michael Duffield
1998 - 2003 Co-Supervisor OXYGEN SENSING IN THE SHEEP ADRENAL MEDULLA Doctor of Philosophy Doctorate Part Time Mr Damien Keating
1997 - 2008 Co-Supervisor Structure Function Studies of Muscle-type CIC Chloride Channels Doctor of Philosophy Doctorate Part Time Mr Brett Bennetts

Memberships

Date Role Membership Country
2007 - 2012 Member National Association of Research Fellows Australia
2003 - ongoing Member Society for General Physiologists Australia
1994 - ongoing Member Member of the Australian Physiological Society Australia

Committee Memberships

Date Role Committee Institution Country
2010 - 2013 Member School of Medical Sciences HDR Committee Australia
2008 - ongoing Member Medical and Scientific Research Advisory Committee of Muscular Dystrophy Association Muscular Dystrophy Association Australia
2007 - ongoing Member AuPS advisory committee on Cell Signalling Australia
1996 - ongoing Chair South Australian Facility for Patch Clamping and Confocal Microscopy University of Adelaide Australia

Offices Held

Date Office Name Institution Country
2014 - ongoing Postgraduate Coordinator South Australian Health and Medical Research Institute Australia
Position
University Senior Research Fellow - D
Phone
81284854
Campus
North Terrace West
Building
SAHMRI, floor 7
Org Unit
Medical Specialties

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