University Senior Research Fellow - D
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Liver Metabolism Group - Group Leader
This group's current research is focused on defining the basic molecular mechanisms that control the activation and regulation of store-operated Ca2+ channels and transient receptor potential (TRP) channels in non- excitable cells and excitable cells, establishing the role of these channels in oxygen sensing, mechanosensation, and generating responses to hormones and neurotransmitters.
- My Research
- Grants and Funding
- Professional Activities
Current Research Projects
1. The role of Store-operated Ca2+ channels in Ca2+ signalling
2. The role of TRP channels in liver physiology and pathology (with Prof Barritt)
3. The role of TRP channels in mechanosensation in the gut (with Dr Brierley)
4. Mechanisms of oxygen sensitivity of TRPV3 channel (with Dr Peet)
5. Regulation of Na+ channels in lung epithelia (with Prof Kumar)
6. Differentiation of adult human dental pulp stem cells into functionally active neurons (with A/Prof Koblar and Prof Gronthos)
Date Position Institution name 2014 University Senior Research Fellow (Level D) University of Adelaide 2013 University Senior Research Fellow (Level D) University of Adelaide 2010 - 2012 NHMRC Senior Research Fellow (Level D) University of Adelaide 2007 - 2009 NHMRC Senior Research Fellow (Level C) University of Adelaide 2002 - 2010 Visiting Senior Lecturer University of Adelaide 2002 - 2006 Australian Research Fellow University of Adelaide 1999 - 2001 Senior Research Associate University of South Australia 1994 - 1998 Research Associate University of South Australia 1990 - 1991 Lecturer Abkhazian State University 1988 - 1992 Research Associate USSR Medical Academy
Awards and Achievements
Date Type Title Institution Name Country Amount 2007 Fellowship NHMRC Senior Research Fellowship National Health and Medical Research Council Australia — 2002 Fellowship Australian Research Council Research Fellowship Australian Research Council Australia — 2002 Achievement Adjunct Senior Lecturer University of South Australia Australia — 1984 Scholarship Armenian Academy of Science Postgraduate Scholarship Armenian Academy of Science Armenia —
Date Institution name Country Title 1985 - 1987 Institute of Experimental Biology, Armenian Academy of Science Armenia, USSR PhD in Biological Sciences (Biophysics) 1979 - 1983 Rostov-on-Don State University Russia Bachelor of Science, Honours (Physics) and Bachelor of Education
Year Citation 2018 Rychkov, G. (2018). Measurement of the CRAC Channel Fast Ca2+-Dependent Inactivation (FCDI). In A. Penna, & B. Constantin (Eds.), Methods in Molecular Biology (Vol. 1843, pp. 167-173). Humana Press.
2017 Kozak, J., & Rychkov, G. (2017). Electrophysiological methods for recording CRAC and TRPV5/6 channels. In J. A. Kozak, & J. W. Putney Jr (Eds.), Calcium Entry Channels in Non-Excitable Cells (pp. 1-23). Boca Raton, FL; USA: CRC Press.
2017 Ali, E., Rychkov, G., & Barritt, G. (2017). Metabolic disorders and cancer: Hepatocyte store-operated Ca(2+) channels in nonalcoholic fatty liver disease. In K. Groschner, W. Graier, & C. Romanin (Eds.), Store-Operated Ca2+ Entry (SOCE) Pathways : Emerging Signaling Concepts in Human (Patho)physiology (Vol. 993, 2nd ed., pp. 595-621). Switzerland: Springer.
DOI Scopus4 WoS2
2011 Rychkov, G., & Barritt, G. (2011). Expression and function of TRP channels in liver cells. In M. Islam (Ed.), Transient Receptor Potential Channels (Vol. 704, pp. 667-686). 233 Spring St New York NY 10013: Springer.
DOI Scopus19 WoS19 Europe PMC13
Year Citation 2018 Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., . . . Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. 2018 Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. 2011 Bretag, A. H., Ma, L., Rychkov, G. Y., Bykova, E. A., & Zheng, J. (2011). Using fluorescence resonance energy transfer (FRET) to reveal the basis for Thomsen's disease. In NEUROMUSCULAR DISORDERS Vol. 21 (pp. 726-727). Algarve, PORTUGAL: PERGAMON-ELSEVIER SCIENCE LTD.
2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden. 2003 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2003). Effect of G, H and I domain mutations on ClC-1 slow gating. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 483A-484A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY. 2003 Wu, W., Simpson, B., Rychkov, G., Hughes, B., & Bretag, A. (2003). Reconstitution of function in ClC-1: Coexpression of its transmembrane domain and small fragments of its carboxyl tail. In JOURNAL OF GENERAL PHYSIOLOGY Vol. 122 (pp. 12A-13A). MARINE BIOL LAB, WOODS HOLE, MASSACHUSETTS: ROCKEFELLER UNIV PRESS.
|Date||Project Title / No.||Investigators||Funding Body||Amount|
|2015 – 2017||Novel regulation of TRP channels by oxygen-dependent hydroxylation||Peet, Rychkov and Gleadle||ARC DP150102860||$364,000|
|2015 – 2017||The role of TRPM2 channels in oxidative stress-induced liver damage||Rychkov, Barritt and Burt||NHMRC APP1086817||$556,000|
|2014 – 2016||Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins||
|University of Adelaide, B3 Establishment Grant||$390,000|
|2011 – 2013||Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity||Brierley, Blackshaw and Rychkov||NHMRC Project Grant||$436,000|
|2008||Patch clamping and imaging cells in tissue slices||Rychkov, Koblar, Gronthos, Kumar, Blackshaw, Brierley, Wilson, Beltrame and Peet||NHMRC Equipment Grant||$75,000|
|2008 - 2010||Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents||Blackshaw, Brierley, Rychkov and Holtmann||NHMRC Project Grant||$641,000|
|2008 - 2010||STIM1 and Orai1 proteins in store-operated Ca2+ entry in liver||Rychkov, Barritt and Wilson||NHMRC Project Grant||$346,000|
|2007 – 2011||Rychkov||NHMRC Senior Research Fellowship||$537,500|
|2005 - 2007||Activation mechanisms of store-operated calcium channels in liver cells||Rychkov and Barritt||ARC Discovery Project||$264,917|
|2002 - 2004||Store-operated calcium channels and liver function||Rychkov, Barritt and Roberts||NHMRC Project Grant||$242,785|
|2002 - 2006||Regulatory mechanisms for calcium release-activated calcium channels||Rychkov, Barritt, and Roberts||ARC Discovery Project and Australian Research Fellowship||$507,499|
|2002||Rychkov||University of Adelaide, B3 Establishment Grant||$11,000|
|2001||Towards chloride channel purification and rational treatment for myotonic muscle stiffness.||Bretag, Rychkov||ATN Small Grant||$17,000|
|2000||Regulation of calcium sensitivity of exocytosis - novel function for the sulphonyrea receptor.||Roberts, Rychkov||ARC Small Grant||$10,000|
|2013||Cellular & Systems Neurobiology||Co-ordinator|
|2011 - 2013||Peripheral Sensory Functions||Lecturer|
|2011 - 2013||Reflexes and Reflex testing||Lecturer|
|2011 - 2013||Skin Physiology||Lecturer|
|2011 - 2013||Ion channels and G-protein coupled receptors||Lecturer|
|2011 - 2013||Cardiovascular Physiology and ANS||Supervised practical|
|1995 - present||3rd year Research Projects of Biomedical Science and Physiology Science students||Supervisor|
|1989 - 1991||Biophysics||Lecturer|
|1989 - 1991||Introduction to molecular endocrinology||Lecturer|
|1989 - 1991||Biomechanics||Lecturer|
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 Co-Supervisor The Role of Itch-Mediating Channels and Receptors in the Urinary Bladder during Health and Hypersensitivity Doctor of Philosophy Doctorate Full Time Ashlee Megan Caldwell 2015 Co-Supervisor Investigation of Colonic Voltage- gated Sodium Channel Function and Expression in Inflammatory and Chronic Visceral Pain States Doctor of Philosophy Doctorate Full Time Ms Andelain Erickson
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2010 - 2011 Co-Supervisor Statin mediated vasodilation in the vaculature Doctor of Philosophy Doctorate Full Time Mr Scott Copley 2010 - 2012 Principal Supervisor The Role of Stim and Orai Proteins in the CalCium Release-Activated CalCium Channel Doctor of Philosophy Doctorate Full Time Mr Nathan Scrimgeour 2010 - 2015 Principal Supervisor The role of TRPM2 channels in oxidative stress-induced liver damage Doctor of Philosophy Doctorate Part Time Mr Ehsan Kheradpezhouh 2009 - 2009 Principal Supervisor Pharmacology of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Edoardo Aromataris 2000 - 2005 Co-Supervisor Gating of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Michael Duffield 1998 - 2003 Co-Supervisor OXYGEN SENSING IN THE SHEEP ADRENAL MEDULLA Doctor of Philosophy Doctorate Part Time Mr Damien Keating 1997 - 2008 Co-Supervisor Structure Function Studies of Muscle-type CIC Chloride Channels Doctor of Philosophy Doctorate Part Time Mr Brett Bennetts
Date Role Committee Institution Country 2010 - 2013 Member School of Medical Sciences HDR Committee — Australia 2008 - ongoing Member Medical and Scientific Research Advisory Committee of Muscular Dystrophy Association Muscular Dystrophy Association Australia 2007 - ongoing Member AuPS advisory committee on Cell Signalling — Australia 1996 - ongoing Chair South Australian Facility for Patch Clamping and Confocal Microscopy University of Adelaide Australia
Date Role Membership Country 2007 - 2012 Member National Association of Research Fellows Australia 2003 - ongoing Member Society for General Physiologists Australia 1994 - ongoing Member Member of the Australian Physiological Society Australia
Date Office Name Institution Country 2014 - ongoing Postgraduate Coordinator South Australian Health and Medical Research Institute Australia
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