Mechanisms of Action of Lipiodol in Women Undergoing Reproductive Therapy. 

The fertility enhancing effects of Lipiodol, an oil soluble contrast medium (OSCM) have been demonstrated, however its mechanism of action remains unclear. This current proposed trial seeks to determine the feasibility, from both the clinical perspective and the laboratory perspective, of changes brought about by lipiodol within the endometrium, the fallopian tubes and the peritoneal lining. This randomised controlled trial (RCT) will then inform the feasibility of testing such variables in a definitive RCT of women with infertility that could, in the future, assess whether such changes are associated with a successful fertility outcome and endometriosis disease modifying effect.