Adelaide Medical School
Faculty of Health and Medical Sciences
Research Manager, Dame Roma Mitchell Cancer Research Laboratories
Dr Kuczek completed her PhD at the University of Adelaide, and undertook postdoctoral work in molecular immunology (signal transduction and transcriptional regulation of cytokines and T cell surface receptors) at the Institute of Medical and Veterinary Science (Adelaide), the University of California, San Francisco (UCSF) and the Gladstone Institute for Virology and Immunology, San Francisco.
Outside of her academic work, Dr Kuczek has a strong background in project and operations management. She has been responsible for the administrative management of large scale multi-institutional national and international projects, including in the area of hormone dependent cancers – a $5million NBCF (National Breast Cancer Foundation) national collaborative research program, and currently, a Movember-NBCF collaborative linkage project. In 1997 she was instrumental in the establishment of the AGRF (Australian Genome Research Facility) in Brisbane, where for 10 years she managed the DNA sequencing services, and the wallaby genome project (at that time the largest genome to be sequenced in Australia), as well as general operations across the three AGRF nodes in Brisbane, Melbourne and Adelaide. Dr Kuczek’s multi-institutional project and stakeholder management was central to her space analyst role with the Go8 (Group of Eight) Facilities Directors group between 2013 -2016.
As a community member of the consumer advisory group for PC4/PoCoG (Primary Care Collaborative Cancer Clinical Trials Group and Psycho-oncology Co-operative Research Group) she has maintained her interest in the translation of research into primary cancer care.
Date Position Institution name 2018 - ongoing Research Manager University of Adelaide 2013 - 2016 Go8 Space Project Manager University of Queensland 2008 - 2013 Project Manager University of Sydney 1997 - 2007 Divisional Manager / National Operations Manager Australian Genome Research Facility 1996 - 1997 National Product Manager Sarstedt AG 1992 - 1994 Staff Research Investigator Gladstone Institute for Virology and Immunology, UCSF
Date Institution name Country Title 1985 University of Adelaide Australia PhD 1981 University of Adelaide Australia BSc (Hons) 1980 University of Adelaide Australia BSc
Date Title Institution Country 1991 - 1992 Postdoctoral Fellow University of California, San Francisco, (UCSF) United States 1987 - 1990 Senior Research Officer Institute of Medical and Veterinary Science Australia
Year Citation 2014 Hilton, H., Doan, T., Dinny Graham, J., Oakes, S., Silvestri, A., Santucci, N., . . . Clarke, C. (2014). Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease. Oncotarget, 5(18), 8651-8664.
DOI Scopus22 WoS21 Europe PMC16
2014 Doan, T., Eriksson, N., Graham, D., Funder, J., Simpson, E., Kuczek, E., . . . Clarke, C. (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology, 8(5), 998-1013.
DOI Scopus17 WoS16 Europe PMC9
2013 Muscat, G., Eriksson, N., Byth, K., Loi, S., Graham, D., Jindal, S., . . . Clarke, C. (2013). Research resource: Nuclear receptors as transcriptome: Discriminant and prognostic value in breast cancer. Molecular Endocrinology, 27(2), 350-365.
DOI Scopus75 WoS75 Europe PMC64
2011 Renfree, M., Papenfuss, A., Deakin, J., Lindsay, J., Heider, T., Belov, K., . . . Hazar-Rethinam, M. (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biology, 12(8), R81-1-R81-25.
DOI Scopus136 WoS141 Europe PMC101
2008 Picardeau, M., Bulach, D. M., Bouchier, C., Zuerner, R. L., Zidane, N., Wilson, P. J., . . . Adler, B. (2008). Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS ONE, 3(2), 9 pages.
DOI Scopus242 WoS219 Europe PMC167
2006 Bulach, D. M., Zuerner, R. L., Wilson, P., Seemann, T., McGrath, A., Cullen, P. A., . . . Adler, B. (2006). Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14560-14565.
DOI Scopus265 WoS253 Europe PMC187
2006 Graves, J. A., & Kuczek, E. S. (2006). Marsupial Research Springs to the Forefront, Editorial. Australian Biochemist, 37(2), 3. 2006 Graves, J. A., & Kuczek, E. S. (2006). The Kangaroo Genome - Australia's Secret Weapon. Australian Biochemist, 37(2), 4-8. 2005 Premzl, M., Delbridge, M., Gready, J. E., Wilson, P., Johnson, M., Davis, J., . . . Marshall Graves, J. A. (2005). The prion protein gene: Identifying regulatory signals using marsupial sequence. Gene, 349, 121-134.
DOI Scopus26 WoS24 Europe PMC20
2003 Saunders, N. F. W., Thomas, T., Curmi, P. M. G., Mattick, J. S., Kuczek, E., Slade, R., . . . Cavicchioli, R. (2003). Mechanisms of thermal adaptatation revealed from genomes of the anatarctic Archaea Methanogenium frigidum and Methanacoccoides burtonii. Genome Research, 13(7), 1580-1588.
DOI Scopus196 WoS191 Europe PMC115
2002 Barlow, J. W., Kuczek, E. S., Mitchelson, K. R., Ewen-White, K. R., & Forrest, S. M. (2002). Genomics research in Australia. Today's Life Science, 14(5), 5. 2001 Ross, B. C., Czajkowski, L., Hocking, D., Margetts, M., Webb, E., Rothel, L., . . . Barr, I. G. (2001). Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis. Vaccine, 19(30), 4135-4142.
DOI Scopus120 WoS97 Europe PMC72
1995 Goldsmith, M. A., Lai, S. Y., Xu, W., Amaral, M. C., Kuczek, E. S., Parent, L. J., . . . Greene, W. C. (1995). Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the β chain and non-tyrosine residues of the γ(c) chain. Journal of Biological Chemistry, 270(37), 21729-21737.
DOI Scopus62 WoS61 Europe PMC41
1994 Goldsmith, M. A., Xu, W., Amaral, M. C., Kuczek, E. S., & Greene, W. C. (1994). The cytoplasmic domain of the interleukin-2 receptor β chain contains both unique and functionally redundant signal transduction elements. Journal of Biological Chemistry, 269(20), 14698-14704.
DOI Scopus55 WoS58 Europe PMC28
1992 Sivaprasad, A. V., Kuczek, E. S., Bawden, C. S., & Rogers, G. E. (1992). Coexpression of the cys E and cys M genes of Salmonella typhimurium in mammalian cells: a step towards establishing cysteine biosynthesis in sheep by transgenesis. Transgenic Research, 1(2), 79-92.
DOI Scopus10 Europe PMC7
1991 Kuczek, E. S., Shannon, M. F., Pell, L. M., & Vadas, M. A. (1991). A granulocyte-colony-stimulating factor gene promoter element responsive to inflammatory mediators is functionally distinct from an identical sequence in the granulocyte-macrophage colony-stimulating factor gene. Journal of Immunology, 146(7), 2426-2433.
Scopus19 WoS23 Europe PMC10
1990 Shannon, M. F., Pell, L. M., Lenardo, M. J., Kuczek, E. S., Occhiodoro, F. S., Dunn, S. M., & Vadas, M. A. (1990). A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes. Molecular and Cellular Biology, 10(6), 2950-2959.
DOI Scopus46 WoS81 Europe PMC34
1989 Shannon, F., & Kuczek, E. (1989). Growth factors. Missing links in CSF gene expression. Today's Life Science, 1(2), 44-45. 1987 KUCZEK, E. S., & ROGERS, G. E. (1987). Sheep wool (glycine + tyrosine)‐rich keratin genes: A family of low sequence homology. European Journal of Biochemistry, 166(1), 79-85.
DOI Scopus53 WoS54 Europe PMC29
1985 KUCZEK, E., & ROGERS, G. E. (1985). Sheep keratins: characterization of cDNA clones for the glycine + tyrosine‐rich wool proteins using a synthetic probe. European Journal of Biochemistry, 146(1), 89-93.
DOI Scopus9 WoS14 Europe PMC9
Year Citation 1989 The Biology of Wool and Hair (1989). Springer Netherlands.
1989 Powell, B., Kuczek, E. S., Crocker, L., O'Donnell, M., & Rogers, G. E. (1989). Keratin Gene Expression in Wool Fibre Development. In G. E. Rogers, P. J. Reis, K. A. Ward, & R. C. Marshall (Eds.), The Biology of Wool and Hair (pp. 325-335). Springer, Dordrecht.
1989 Rogers, G. E., Kuczek, E. S., Mackinnon, P. J., Presland, R. B., & Fietz, M. J. (1989). Special Biochemical Features of the Hair Follicle. In G. E. Rogers, P. J. Reis, K. A. Ward, & R. C. Marshall (Eds.), The Biology of Wool and Hair. Springer, Dordrecht.
Date Role Committee Institution Country 2017 - 2018 Secretary Institutional Biosafety Committee University of Adelaide Australia 2012 - 2014 Member Wesley Hospital - Community Advisory Committee Wesley Private Hospital Australia 2011 - 2018 Member Joint Consumer Advisory Group (JCAG) PC4/POCOG (Primary Care Collaborative Cancer Clinical Trials / Pyscho-oncology Co-operative Research Group Australia
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