Dorothy Keefe

Ms Dorothy Keefe

School of Medicine

College of Health

Professor Keefe is the CEO of Cancer Australia, and an honorary Clinical Professor in the School of Medicine at the University of Adelaide. She has had a long career as a Medical Oncologist, and Professor of Cancer Medicine.Her areas of expertise include gastrointestinal toxicity of cancer treatment, Supportive Care in Cancer more broadly, Medical Leadership and Health Reform, and she has published extensively in the Supportive Care literature. She has a long-standing commitment to the Multinational Association of Supportive Care in Cancer (MASCC), and is a past-president. All her work is focused on improving outcomes for patients .

Professor Keefe is the Interim Director of the SA Cancer Service, Professor of Cancer Medicine at the University of Adelaide, and a Senior Medical Oncologist at Royal Adelaide Hospital. She is a Past-President of the Multinational Association of Supportive Care in Cancer (MASCC).

Dorothy Keefe graduated in Medicine from the University of London in 1986, migrated to Australia and became a Fellow of the Royal Australasian College of Physicians (FRACP) in 1996. She received her Doctorate of Medicine from the University of Adelaide in 1999, for a thesis entitled ‘The effect of cytotoxic chemotherapy on the mucosa of the small intestine’.

Professor Keefe’s research interest is in toxicity of cancer treatment, particularly mucositis and how it links to other toxicities. Her laboratory work investigates chemotherapy and radiotherapy-induced whole gut damage, and the efficacy of new agents in prevention and treatment. She has authored over 100 peer-reviewed publications in this area.

In the 2013 Queen’s Birthday Honours Professor Keefe received the Public Service Medal for “outstanding service in the areas of Public Health, Medical Research and Oncology”. And in 2014 she received the MASCC Distinguished Service Award for “longstanding, devoted and exemplary service to MASCC”.

She has recently completed a Master’s of Science (MSc) in Medical Leadership at Birbeck College, University of London and her thesis was titled “Using Clinical Leadership to Drive Success in Making the ‘Case for Change’ for Healthcare Reform: A Case Study from the South Australian Transforming Health Program.

Date Position Institution name
2019 - 2019 Professor of Cancer Medicine University of Adelaide
2014 - 2017 Clinical Ambassador SA Health
2011 - 2015 Service Director SA Cancer Service SA Health
2010 - 2011 Regional Clinical Director Adelaide Health Service Cancer Services
2009 - 2013 Chair South Australian Cancer Clinical Network, SA Health
2007 - 2010 Clinical Director Royal Adelaide Hospital
2007 - 2009 Chair MBBS Curriculum Committee (Operations) University of Adelaide
2007 - 2009 Deputy Chair South Australian Cancer Clinical Network
2006 - 2008 Chair MBBS Curriculum Committee University of Adelaide
2006 - 2007 Interim Clinical Director Royal Adelaide Hospital
2005 - 2007 Associate Professor in Oncological Medicine The University of Adelaide
2001 - ongoing Senior Consultant Medical Oncologist Royal Adelaide Hospital
2000 - 2004 Clinical Senior Lecturer University of Adelaide
1999 - 2002 Consultant Medical Oncologist (Access appointment) Queen Elizabeth Hospital
1999 - 2001 Associate Specialist Queen Elizabeth Hospital
1996 - 2000 Consultant Medical Oncologist Royal Adelaide Hospital
1996 - 1999 Clinical Lecturer University of Adelaide
1996 - 1997 Anti-Cancer Foundation Research Associate Queen Elizabeth Hospital
1995 - 1998 Gastroenterology Research Fellow Queen Elizabeth Hospital
1992 - 1994 Medical Oncology/Haematology Registrar Queen Elizabeth Hospital
1989 - 1992 Basic Physician Trainee Queen Elizabeth Hospital
1988 - 1988 Senior House Officer Royal Cornwall Hospital
1987 - 1988 Medical Officer/Watch Officer Britain Australia Bicentennial Schooner Trust
1986 - 1987 Medical and Surgical House Officer Royal Cornwall Hospital

Date Type Title Institution Name Country Amount
2014 Award MASCC Distinguished Service Award Multinational Association of Supportive Care in Cancer - -
2013 Honour Public Service Medal Queen's Birthday Honour Australia -
2009 Fellowship Woman of Achievement Award Royal College of Physicians (London) United Kingdom -
1998 Award Clinical Research Prize Queen Elizabeth Hospital Research Day Australia -
1993 Award Clinical Research Prize Queen Elizabeth Hospital Research Day Australia -
1993 Award Best Physician Trainee Queen Elizabeth Hospital Australia -

Date Institution name Country Title
2016 Birkbeck College UK Masters of Science (MSc) Medical Leadership
1999 University of Adelaide Australia Doctor of Medicine
1985 University of London UK Bachelor of Medicine and Bachelor of Surgery (MBBS)

Year Citation
2025 Elston, J., Nehill, C., & Keefe, D. M. (2025). Strengthening cancer education evidence to achieve equity in outcomes for First Nations Australians. Lancet Regional Health Western Pacific, 61, 101565.
DOI Scopus1
2024 Abdalla-Aslan, R., Bonomo, P., Keefe, D., Blijlevens, N., Cao, K., Cheung, Y. T., . . . Nagano, C. (2024). Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study. eClinicalMedicine, 73(102675), 102675-1-102675-12.
DOI Scopus8 WoS9 Europe PMC7
2024 Roseleur, J., Karnon, J., de Koning, H., Milch, V., Anderson, K., Real, J., . . . ten Haaf, K. (2024). Targeted lung cancer screening in the age of immunotherapies and targeted therapies – an economic evaluation for Australia. Lancet Regional Health Western Pacific, 53, 13 pages.
DOI Scopus6 WoS6 Europe PMC3
2024 Chaji, D., Malloy, L., Meredyth, D., Milch, V., Toms, C., Howlett, C., & Keefe, D. (2024). Implementing Australia’s first national cancer control plan to shape Australian cancer control policy for the next decade and beyond. Holistic Integrative Oncology, 3(1).
DOI Scopus5
2023 Anderson, K., Gall, A., Butler, T., Ngampromwongse, K., Hector, D., Turnbull, S., . . . Garvey, G. (2023). Development of Key Principles and Best Practices for Co-Design in Health with First Nations Australians. International Journal of Environmental Research and Public Health, 20(1), 147.
DOI Scopus48 WoS36 Europe PMC29
2023 Chaji, D., Boltong, A., Der Vartanian, C., Lambert, A., Toms, C., Milch, V., . . . Keefe, D. (2023). Setting the policy agenda for cancer control reform: Australia's first national cancer control plan. Medical Journal of Australia, 219(10), 451-454.
DOI Scopus6 WoS3 Europe PMC2
2023 Korver, S. K., Bowen, J. M., Gibson, R. J., Ball, I. A., Secombe, K. R., Wain, T. J., . . . Coller, J. K. (2023). Advanced statistics identifcation of participant and treatment predictors associated with severe adverse efects induced by fuoropyrimidine‑based chemotherapy. Cancer Chemother Pharmacol, 91(6), 507-521.
DOI Scopus3 WoS3 Europe PMC3
2023 Chan, R. J., Milch, V. E., Crawford-Williams, F., Agbejule, O. A., Joseph, R., Johal, J., . . . Hart, N. H. (2023). Patient navigation across the cancer care continuum: An overview of systematic reviews and emerging literature. CA: A Cancer Journal for Clinicians, 73(6), 565-589.
DOI Scopus177 WoS172 Europe PMC153
2022 Body, A., Milch, V., McSorley, L., Lal, L., Ahern, E., Ryan, R., . . . Segelov, E. (2022). Rapid Protocol Development, Study Startup and Enrolment of a Prospective Study of COVID-19 Vaccination for Patients with Cancer: A Collaborative Approach. Vaccines, 10(12), 2003.
DOI
2022 Milch, V., Nelson, A. E., Austen, M., Hector, D., Turnbull, S., Sathiaraj, R., . . . Keefe, D. (2022). Conceptual Framework for Cancer Care During a Pandemic Incorporating Evidence From the COVID-19 Pandemic. JCO Global Oncology, 8(8), e2200043.
DOI Scopus3 WoS3 Europe PMC3
2022 Secombe, K. R., Ball, I. A., Wignall, A. D., Bateman, E., Keefe, D. M., & Bowen, J. M. (2022). Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats. Neoplasia, 30(article no. 100806), 100806-1-100806-10.
DOI Scopus13 WoS13 Europe PMC13
2022 Delany, C., Milch, V., Keefe, D., & Wong, Z. W. (2022). COVID-19 recovery: implications for cancer care clinicians. Supportive Care in Cancer, 30(2), 1003-1006.
DOI Scopus3 WoS4 Europe PMC3
2022 Araújo, R. S., Oliveira, M. C., Cardoso, V. N., Keefe, D. M. K., & Stringer, A. M. (2022). The effect of free and encapsulated cisplatin into long-circulating and pH-sensitive liposomes on IEC-6 cells during wound healing in the presence of host-microbiota. Journal of Pharmacy and Pharmacology, 74(5), 711-717.
DOI Scopus1 WoS1 Europe PMC2
2022 Butler, T., Gall, A., Garvey, G., Ngampromwongse, K., Hector, D., Turnbull, S., . . . Anderson, K. (2022). A Comprehensive Review of Optimal Approaches to Co-Design in Health with First Nations Australians. International Journal of Environmental Research and Public Health, 19(23), 1-38.
DOI Scopus73 Europe PMC45
2022 Wardill, H. R., Chan, R. J., Chan, A., Keefe, D., Costello, S. P., & Hart, N. H. (2022). Dual contribution of the gut microbiome to immunotherapy efficacy and toxicity: supportive care implications and recommendations.. Support Care Cancer, 30(8), 6369-6373.
DOI Scopus10 WoS10 Europe PMC8
2021 Milch, V., Aranda, S., Canfell, K., Varlow, M., Roder, D. M., Currow, D., . . . Keefe, D. (2021). Overdiagnosis of screen-detected breast cancer. Medical Journal of Australia, 214(10), 455e1-456e1.
DOI Scopus1 Europe PMC2
2021 Milch, V., Hector, D., Turnbull, S., Sathiaraj, R., Jackson, P., Anderiesz, C., & Keefe, D. (2021). Cancer Australia's Response to the COVID-19 Pandemic. Clinical Oncology, 33(1), e58-e60.
DOI Europe PMC1
2021 Milch, V., Wang, R., Der Vartanian, C., Austen, M., Hector, D., Anderiesz, C., & Keefe, D. (2021). Cancer Australia consensus statement on COVID-19 and cancer care: embedding high value changes in practice. Medical Journal of Australia, 215(10), 479-484.
DOI Scopus10 Europe PMC9
2021 Secombe, K. R., Ball, I. A., Shirren, J., Wignall, A. D., Keefe, D. M., & Bowen, J. M. (2021). Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.. Breast Cancer, 28(1), 99-109.
DOI Scopus12 WoS9 Europe PMC10
2020 Elad, S., Cheng, K. K. F., Lalla, R. V., Yarom, N., Hong, C., Logan, R. M., . . . Zur, E. (2020). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 126(19), 4423-4431.
DOI Scopus536 WoS506 Europe PMC361
2020 Wan Mohamad Zain, W. N. I. Z., Bowen, J., Bateman, E., & Keefe, D. (2020). Cytotoxic Effects of the Dual ErbB Tyrosine Kinase Inhibitor, Lapatinib, on Walker 256 Rat Breast Tumour and IEC-6 Rat Normal Small Intestinal Cell Lines.. Biomedicines, 8(1), 2-1-2-14.
DOI Scopus5 WoS4 Europe PMC5
2020 Mayo, B., Secombe, K., Wignall, A., Bateman, E., Thorpe, D., Pietra, C., . . . Bowen, J. (2020). The GLP-2 Analogue Elsiglutide Reduces Diarrhoea Caused by the Tyrosine Kinase Inhibitor Lapatinib in Rats. Cancer Chemotherapy and Pharmacology, 85(4), 793-803.
DOI Scopus26 WoS21 Europe PMC22
2020 Olver, I., Keefe, D., Herrstedt, J., Warr, D., Roila, F., & Ripamonti, C. I. (2020). Supportive care in cancer-a MASCC perspective.. Support Care Cancer, 28(8), 3467-3475.
DOI Scopus92 WoS87 Europe PMC72
2020 Chiam, K., Mayne, G. C., Wang, T., Watson, D. I., Irvine, T. S., Bright, T., . . . Hussey, D. J. (2020). Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus. World Journal of Gastroenterology, 26(20), 2570-2583.
DOI Scopus20 WoS19 Europe PMC20
2020 Roder, D., Selva-Nayagam, S., Paramasivam, S., Keefe, D., Olver, I., Miller, C., . . . Oehler, M. (2020). Cancers of the corpus uteri treated in South Australian public hospitals: Trends in clinical management and survival across three decades.. Eur J Cancer Care (Engl), 29(5), 1-12.
DOI
2019 Li, M., Olver, I., Keefe, D., Holden, C., Worthley, D., Price, T., . . . Roder, D. (2019). Pre-diagnostic colonoscopies reduce cancer mortality - Results from linked population-based data in South Australia. BMC Cancer, 19(1), 856.
DOI Scopus10 WoS8 Europe PMC3
2019 Tarricone, R., Cucciniello, M., Armeni, P., Petracca, F., Desouza, K. C., Hall, L. K., & Keefe, D. (2019). Mobile Health Divide Between Clinicians and Patients in Cancer Care: Results From a Cross-Sectional International Survey. JMIR MHEALTH AND UHEALTH, 7(9), 16 pages.
DOI Scopus25 WoS20 Europe PMC18
2019 Keefe, D. M. K., & Bateman, E. H. (2019). Potential Successes and Challenges of Targeted Cancer Therapies. Journal of the National Cancer Institute. Monographs, 2019(53), lgz008.
DOI Scopus45 Europe PMC35
2019 Lalla, R. V., Brennan, M. T., Gordon, S. M., Sonis, S. T., Rosenthal, D. I., & Keefe, D. M. (2019). Oral Mucositis Due to High-Dose Chemotherapy and/or Head and Neck Radiation Therapy. Journal of the National Cancer Institute. Monographs, 2019(53), lgz011.
DOI Scopus110 Europe PMC53
2019 Roder, D., Karapetis, C. S., Olver, I., Keefe, D., Padbury, R., Moore, J., . . . Price, T. (2019). Time from diagnosis to treatment of colorectal cancer in a South Australian clinical registry cohort: how it varies and relates to survival.. BMJ open, 9(9), 1-11.
DOI Scopus30 WoS22 Europe PMC24
2019 Tarricone, R., Cucciniello, M., Armeni, P., Petracca, F., Desouza, K. C., Hall, L. K., & Keefe, D. (2019). Mobile Health Divide Between Clinicians and Patients in Cancer Care: Results From a Cross-Sectional International Survey (Preprint).
DOI
2019 Roder, D., Davy, M., Selva-Nayagam, S., Paramasivam, S., Adams, J., Keefe, D., . . . Oehler, M. K. (2019). Exploring the added value of hospital-registry data for showing local service outcomes: Cancers of the ovary, fallopian tube and peritoneum. BMJ Open, 9(2), e024036.
DOI Scopus1 WoS1
2019 Banham, D., Roder, D., Keefe, D., Farshid, G., Eckert, M., Howard, N., . . . Brown, A. (2019). Disparities in breast screening, stage at diagnosis, cancer treatment and the subsequent risk of cancer death: a retrospective, matched cohort of aboriginal and non-aboriginal women with breast cancer. BMC Health Services Research, 19(1), 387-1-387-11.
DOI Scopus24 WoS22 Europe PMC18
2019 Bowen, J. M., Gibson, R. J., Coller, J. K., Blijlevens, N., Bossi, P., Al-Dasooqi, N., . . . Elad, S. (2019). Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines. Supportive Care in Cancer, 27(10), 4011-4022.
DOI Scopus75 WoS60 Europe PMC46
2019 Secombe, K., Ball, I., Shirren, J., Wignall, A., Finnie, J., Keefe, D., . . . Bowen, J. (2019). Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model. Cancer Chemotherapy and Pharmacology, 83(3), 531-543.
DOI Scopus18 WoS12 Europe PMC14
2019 Lee, A., Bowen, J., Su, Y., Plews, E., Chung, R., Keefe, D. M., & Xian, C. (2019). Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats. Journal of Cellular Biochemistry, 120(3), 4180-4191.
DOI Scopus5 WoS5 Europe PMC6
2019 Ahmedzai, S. H., Bautista, M. J., Bouzid, K., Gibson, R., Gumara, Y., Hassan, A. A. I., . . . Wang, J. J. (2019). Optimizing cancer pain management in resource-limited settings. Supportive Care in Cancer, 27(6), 2113-2124.
DOI Scopus16 WoS15 Europe PMC14
2018 Stansborough, R. L., Al-Dasooqi, N., Bateman, E. H., Bowen, J. M., Keefe, D. M. K., Logan, R. M., . . . Gibson, R. J. (2018). Matrix metalloproteinase expression is altered in the small and large intestine following fractionated radiation in vivo. Supportive Care in Cancer, 26(11), 3873-3882.
DOI Scopus8 WoS8 Europe PMC6
2018 Stansborough, R. L., Bateman, E. H., Al-Dasooqi, N., Bowen, J. M., Wignall, A., Keefe, D. M., . . . Gibson, R. J. (2018). Vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), angiostatin, and endostatin are increased in radiotherapy-induced gastrointestinal toxicity. International Journal of Radiation Biology, 94(7), 645-655.
DOI Scopus8 WoS6 Europe PMC6
2018 Roder, D., Davy, M., Selva-Nayagam, S., Paramasivam, S., Adams, J., Keefe, D., . . . Oehler, M. (2018). Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival. BMC Cancer, 18(1), 10 pages.
DOI Scopus6 WoS6 Europe PMC5
2018 Jordan, K., Aapro, M., Kaasa, S., Ripamonti, C., Scotté, F., Strasser, F., . . . Cervantes, A. (2018). European Society for Medical Oncology (ESMO) position paper on supportive and palliative care.. Annals of Oncology, 29(1), 36-43.
DOI Scopus284 WoS261 Europe PMC250
2018 Van Sebille, Y., Gibson, R., Wardill, H., Ball, I., Keefe, D., & Bowen, J. (2018). Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer. International Journal of Cancer, 142(2), 369-380.
DOI Scopus16 WoS15 Europe PMC16
2018 Allen, G., Logan, R., Revesz, T., Keefe, D., & Gue, S. (2018). The prevalence and investigation of risk factors of oral mucositis in a pediatric oncology inpatient population; a prospective study. Journal of Pediatric Hematology/Oncology, 40(1), 15-21.
DOI Scopus34 WoS33 Europe PMC23
2017 Roder, D., Davy, M., Selva-Nayagam, S., Gowda, R., Paramasivam, S., Adams, J., . . . Oehler, M. (2017). The value of local registry data for describing cervical cancer management and outcomes over three decades in Australia. European Journal of Cancer Care, 27(1), e12760-1-e12760-14.
DOI
2017 Roder, D., Farshid, G., Kollias, J., Koczwara, B., Karapetis, C., Adams, J., . . . Price, T. (2017). Female breast cancer management and survival: the experience of major public hospitals in South Australia over 3 decades-trends by age and in the elderly. Journal of Evaluation in Clinical Practice, 23(6), 1433-1443.
DOI Scopus6 WoS7 Europe PMC5
2017 Banham, D., Roder, D., Keefe, D., Farshid, G., Eckert, M., Cargo, M., & Brown, A. (2017). Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians. Cancer Epidemiology, 48, 131-139.
DOI Scopus21 WoS20 Europe PMC18
2017 Fan, C., Georgiou, K., Morris, H., McKinnon, R., Keefe, D., Howe, P., & Xian, C. (2017). Combination breast cancer chemotherapy with doxorubicin and cyclophosphamide damages bone and bone marrow in a female rat model. Breast Cancer Research and Treatment, 165(1), 41-51.
DOI Scopus41 WoS39 Europe PMC36
2017 Stansborough, R., Bateman, E., Al-Dasooqi, N., Bowen, J., Keefe, D., Yeoh, A., . . . Gibson, R. (2017). Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity. Supportive Care in Cancer, 25(6), 1973-1983.
DOI Scopus15 WoS14 Europe PMC13
2017 Kim, D., Garon, E., Jatoi, A., Keefe, D., Lacouture, M., Sonis, S., . . . Cho, B. (2017). Impact of a planned dose interruption of dacomitinib in the treatment of advanced non-small-cell lung cancer (ARCHER 1042). Lung Cancer, 106, 76-82.
DOI Scopus13 WoS13 Europe PMC11
2017 Buckley, E., Farshid, G., Gill, G., Kollias, J., Koczwara, B., Karapetis, C., . . . Roder, D. (2017). Assessing impact of organised breast screening across small residential areas-development and internal validation of a prediction model. European Journal of Cancer Care, 26(4), e12673-1-e12673-8.
DOI
2017 Van Sebille, Y., Gibson, R., Wardill, H., Secombe, K., Ball, I., Keefe, D., . . . Bowen, J. (2017). Dacomitinib-induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats. International Journal of Cancer, 140(12), 2820-2829.
DOI Scopus33 WoS29 Europe PMC30
2017 Roder, D., Farshid, G., Gill, G., Kollias, J., Koczwara, B., Karapetis, C., . . . Beckmann, K. (2017). Breast cancer screening-opportunistic use of registry and linked screening data for local evaluation. Journal of Evaluation in Clinical Practice, 23(3), 508-516.
DOI Scopus4 WoS2 Europe PMC2
2017 Al-Dasooqi, N., Bowen, J., Bennett, C., Finnie, J., Keefe, D., & Gibson, R. (2017). Cell adhesion molecules are altered during irinotecan-induced mucositis: a qualitative histopathological study. Supportive Care in Cancer, 25(2), 391-398.
DOI Scopus7 WoS6 Europe PMC4
2017 Mayo, B., Stringer, A., Bowen, J., Bateman, E., & Keefe, D. (2017). Irinotecan-induced mucositis: the interactions and potential role of GLP-2 analogues. Cancer Chemotherapy and Pharmacology, 79(2), 233-249.
DOI Scopus19 WoS17 Europe PMC15
2017 Campbell, J., Stephenson, M., Bateman, E., Peters, M., Keefe, D., & Bowen, J. (2017). Irinotecan-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses. Pharmacogenomics Journal, 17(1), 21-28.
DOI Scopus57 WoS49 Europe PMC39
2016 Roder, D., Karapetis, C., Wattchow, D., Moore, J., Singhal, N., Joshi, R., . . . Price, T. (2016). Colorectal cancer treatment and survival over three decades at four major public hospitals in South Australia: trends by age and in the elderly. European Journal of Cancer Care, 25(5), 753-763.
DOI Scopus4 WoS4 Europe PMC4
2016 Keefe, D., Al Garni, A., Villalon, A., Hassan, A., Kwong, D., Li, P., . . . Aapro, M. (2016). Challenges in supportive cancer care: perspectives from the Asia Pacific and Middle East. Supportive Care in Cancer, 24(11), 4479-4481.
DOI Scopus11 WoS10 Europe PMC8
2016 Bala, V., Rao, S., Bateman, E., Keefe, D., Wang, S., & Prestidge, C. (2016). Enabling oral SN38-based chemotherapy with a combined lipophilic prodrug and self-microemulsifying drug delivery system. Molecular Pharmaceutics, 13(10), 3518-3525.
DOI Scopus45 WoS43 Europe PMC29
2016 Hu, Z., Liang, W., Yang, Y., Keefe, D., Ma, Y., Zhao, Y., . . . Zhang, L. (2016). Personalized estimate of chemotherapy-induced nausea and vomiting: development and external validation of a nomogram in cancer patients receiving highly/moderately emetogenic chemotherapy. Medicine, 95(2), e2476-1-e2476-6.
DOI Scopus32 WoS23 Europe PMC21
2016 Allen, G., Revesz, T., Logan, R., Keefe, D., & Gue, S. (2016). The development of an evidenced-based and clinically trialled Oral Health Protocol for Paediatric Oncology Patients at the Women’s and Children’s Hospital, Adelaide, South Australia. Supportive Care in Cancer, 24(5), 1933-1934.
DOI Scopus1 WoS1 Europe PMC1
2016 Stansborough, R., Al-dasooqi, N., Bateman, E., Keefe, D., & Gibson, R. (2016). Radiotherapy-induced gut toxicity: involvement of matrix metalloproteinases and the intestinal microvasculature. International Journal of Radiation Biology, 92(5), 241-248.
DOI Scopus16 WoS15 Europe PMC12
2016 Ruhlmann, C., Christensen, T., Dohn, L., Paludan, M., Rønnengart, E., Halekoh, U., . . . Herrstedt, J. (2016). Efficacy and safety of fosaprepitant for the prevention of nausea and emesis during 5 weeks of chemoradiotherapy for cervical cancer (the GAND-emesis study): a multinational, randomised, placebo-controlled, double-blind, phase 3 trial. The Lancet Oncology, 17(4), 509-518.
DOI Scopus45 WoS40 Europe PMC27
2016 Bateman, E. H., & Keefe, D. M. K. (2016). How can eHealth enhance adherence to cancer therapy and supportive care?. Srpski Arhiv Za Celokupno Lekarstvo, 144(1-2), 116-121.
DOI Scopus8 WoS7 Europe PMC7
2016 Lacouture, M., Keefe, D., Sonis, S., Jatoi, A., Gernhardt, D., Wang, T., . . . Garon, E. (2016). A phase II study (ARCHER 1042) to evaluate prophylactic treatment of dacomitinib-induced dermatologic and gastrointestinal adverse events in advanced non-small-cell lung cancer. Annals of Oncology, 27(9), 1712-1718.
DOI Scopus59 WoS51 Europe PMC48
2016 Bateman, E., Weaver, E., Klein, G., Wignall, A., Wozniak, B., Plews, E., . . . Keefe, D. (2016). Serum-derived bovine immunoglobulin/protein isolate in the alleviation of chemotherapy-induced mucositis. Supportive Care in Cancer, 24(1), 377-385.
DOI Scopus10 WoS11 Europe PMC11
2015 Fan, C., Georgiou, K. R., McKinnon, R. A., Keefe, D. M. K., Howe, P. R. C., & Xian, C. J. (2015). Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats. Journal of Bone and Mineral Metabolism, 34(3), 277-290.
DOI Scopus31 WoS30 Europe PMC27
2015 Perez, D., Sharples, K., Broom, R., Jeffery, M., Proctor, J., Hinder, V., . . . Findlay, M. (2015). A randomised phase IIb trial to assess the efficacy of ReCharge ice cream in preventing chemotherapy-induced diarrhoea. Supportive Care in Cancer, 23(11), 3307-3315.
DOI Scopus9 WoS7 Europe PMC6
2015 Bowen, J., White, I., Smith, L., Tsykin, A., Kristaly, K., Thompson, S., . . . Keefe, D. (2015). Pre-therapy mRNA expression of TNF is associated with regimen-related gastrointestinal toxicity in patients with esophageal cancer: a pilot study. Supportive Care in Cancer, 23(11), 3165-3172.
DOI Scopus9 WoS8 Europe PMC9
2015 Roder, D., Karapetis, C., Wattchow, D., Moore, J., Singhal, N., Joshi, R., . . . Price, T. (2015). Colorectal cancer treatment and survival : the experience of major public hospitals in South Australia over three decades. Asian Pacific Journal of Cancer Prevention, 16(6), 2431-2440.
DOI Scopus28 Europe PMC29
2015 Chiam, K., Wang, T., Watson, D., Mayne, G., Irvine, T., Bright, T., . . . Hussey, D. (2015). Circulating serum exosomal miRNAs as potential biomarkers for esophageal adenocarcinoma. Journal of Gastrointestinal Surgery, 19(7), 1208-1215.
DOI Scopus131 WoS120 Europe PMC113
2015 Vanhoecke, B., Bateman, E., Mayo, B., Vanlancker, E., Stringer, A., Thorpe, D., & Keefe, D. (2015). Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art. Experimental Biology and Medicine, 240(6), 725-741.
DOI Scopus30 WoS26 Europe PMC22
2015 Chan, A., Kim, H., Hsieh, R., Yu, S., de Lima Lopes, G., Su, W., . . . Keefe, D. (2015). Incidence and predictors of anticipatory nausea and vomiting in Asia Pacific clinical practice—a longitudinal analysis. Supportive Care in Cancer, 23(1), 283-291.
DOI Scopus33 WoS35 Europe PMC29
2015 Yu, S., Burke, T., Chan, A., Kim, H., Hsieh, R., Hu, X., . . . Keefe, D. (2015). Antiemetic therapy in Asia Pacific countries for patients receiving moderately and highly emetogenic chemotherapy-a descriptive analysis of practice patterns, antiemetic quality of care, and use of antiemetic guidelines. Supportive Care in Cancer, 23(1), 273-282.
DOI Scopus30 WoS27 Europe PMC27
2015 Sonis, S., Elting, L., Keefe, D., Nguyen, H., Grunberg, S., Randolph-Jackson, P., & Brennan, M. (2015). Unanticipated frequency and consequences of regimen-related diarrhea in patients being treated with radiation or chemoradiation regimens for cancers of the head and neck or lung. Supportive Care in Cancer, 23(2), 433-439.
DOI Scopus20 WoS17 Europe PMC14
2015 Vanhoecke, B., De Ryck, T., Stringer, A., Van de Wiele, T., & Keefe, D. (2015). Microbiota and their role in the pathogenesis of oral mucositis. Oral Diseases, 21(1), 17-30.
DOI Scopus94 WoS78 Europe PMC74
2015 Al-Azri, A. R., Gibson, R. J., Bowen, J. M., Stringer, A. M., Keefe, D. M., & Logan, R. M. (2015). Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis. Journal of Oral Pathology & Medicine, 44(6), 459-467.
DOI Scopus33 WoS31 Europe PMC24
2015 Kim, H., Hsieh, R., Chan, A., Yu, S., Han, B., Gao, Y., . . . Keefe, D. (2015). Impact of CINV in earlier cycles on CINV and chemotherapy regimen modification in subsequent cycles in Asia Pacific clinical practice. Supportive Care in Cancer, 23(1), 293-300.
DOI Scopus22 WoS21 Europe PMC20
2015 Lalla, R. V., Bowen, J., Barasch, A., Elting, L., Epstein, J., Keefe, D. M., . . . Elad, S. (2015). Erratum: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy (Cancer (2014) 120 (1453-1661)). Cancer, 121(8), 1339.
DOI WoS2
2015 Bessen, T., Keefe, D. M. K., & Karnon, J. (2015). Does one size fit all? Cost utility analyses of alternative mammographic follow-up schedules, by risk of recurrence. International Journal of Technology Assessment in Health Care, 31(5), 281-288.
DOI Scopus9 WoS8 Europe PMC8
2015 Campbell, J., Bateman, E., Stephenson, M., Bowen, J., Keefe, D., & Peters, M. D. (2015). Methotrexate-induced Toxicity Pharmacogenetics; an Umbrella Review of Systematic reviews and Meta-analyses. Tumor Biology: from basic science to clinical application, 78(1), 27-39.
DOI Scopus58 WoS51 Europe PMC30
2015 Campbell, J., Bateman, E., Peters, M. D., Bowen, J., Keefe, D., & Stephenson, M. (2015). Fluoropyrimidine and Platinum Toxicity Pharmacogenetics: an Umbrella Review of Systematic reviews and Meta-analyses. FutureMedicine Pharmacogenomics, 17(4), 435-451.
DOI Scopus35 WoS23 Europe PMC26
2015 Roder, D., Karapetis, C., Wattchow, D., Moore, J., Singhal, N., Joshi, R., . . . Price, T. (2015). Metastatic colorectal cancer treatment and survival: the experience of major public hospitals in South Australia over three decades. Asian Pacific Journal of Cancer Prevention, 16(14), 5923-5931.
DOI Scopus12 Europe PMC3
2015 Van Sebille, Y., Stansborough, R., Wardill, H., Bateman, E., Gibson, R., & Keefe, D. (2015). Management of mucositis during chemotherapy: from pathophysiology to pragmatic therapeutics. Current Oncology Reports, 17(11), 50-1-50-8.
DOI Scopus73 WoS62 Europe PMC48
2015 Peeters, S., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J., Schalkwijk, C., . . . EURODIAB Prospective Complications Study Group. (2015). Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: The EURODIAB Prospective Complications Study. Cardiovascular Diabetology, 14(1), 31-1-31-10.
DOI Scopus55 Europe PMC48
2014 Laven, G., Keefe, D., Duggan, P., & Tonkin, A. (2014). How was the intern year?: self and clinical assessment of four cohorts, from two medical curricula. BMC Medical Education, 14(1), 123-1-123-10.
DOI Scopus4 WoS7 Europe PMC5
2014 Keefe, D., Elting, L., Nguyen, H., Grunberg, S., Aprile, G., Bonaventura, A., . . . Sonis, S. (2014). Risk and outcomes of chemotherapy-induced diarrhea (CID) among patients with colorectal cancer receiving multi-cycle chemotherapy. Cancer Chemotherapy and Pharmacology, 74(4), 675-680.
DOI Scopus39 WoS34 Europe PMC30
2014 Hsieh, R., Chan, A., Kim, H., Yu, S., Kim, J., Lee, M., . . . Keefe, D. (2014). Baseline patient characteristics, incidence of CINV, and physician perception of CINV incidence following moderately and highly emetogenic chemotherapy in Asia Pacific countries. Supportive Care in Cancer, 23(1), 263-272.
DOI Scopus48 WoS49 Europe PMC44
2014 Khaw, A., Liberali, S., Logan, R., Keefe, D., & Bartold, P. (2014). Influence of periodontitis on the experience of oral mucositis in cancer patients undergoing head and neck radiotherapy: a pilot study. Supportive Care in Cancer, 22(8), 2119-2125.
DOI Scopus18 WoS15 Europe PMC12
2014 Keefe, D., Chan, A., Kim, H., Hsieh, R., Yu, S., Wang, Y., . . . Burke, T. (2014). Rationale and design of the Pan Australasian chemotherapy-induced emesis burden of illness study. Supportive Care in Cancer, 23(1), 253-261.
DOI Scopus7 WoS5 Europe PMC7
2014 Bessen, T., Chen, G., Street, J., Eliott, J., Karnon, J., Keefe, D., & Ratcliffe, J. (2014). What sort of follow-up services would Australian breast cancer survivors prefer if we could no longer offer long-term specialist-based care? A discrete choice experiment. British Journal of Cancer, 110(4), 859-867.
DOI Scopus40 WoS38 Europe PMC29
2014 Bowen, J., Mayo, B., Plews, E., Bateman, E., Wignall, A., Stringer, A., . . . Keefe, D. (2014). Determining the mechanisms of lapatinib-induced diarrhoea using a rat model. Cancer Chemotherapy and Pharmacology, 74(3), 617-627.
DOI Scopus27 WoS22 Europe PMC19
2014 Lalla, R. V., Bowen, J., Barasch, A., Elting, L., Epstein, J., Keefe, D. M., . . . The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). (2014). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 120(10), 1453-1461.
DOI Scopus925 WoS693 Europe PMC645
2014 Chan, A., Lees, J., & Keefe, D. (2014). The changing paradigm for supportive care in cancer patients. Supportive Care in Cancer, 22(6), 1441-1445.
DOI Scopus10 WoS5 Europe PMC6
2013 Khaw, A., Logan, R., Keefe, D., & Bartold, M. (2013). Radiation-induced oral mucositis and periodontitis - proposal for an inter-relationship. Oral Diseases, 20(3), e7-e18.
DOI Scopus49 WoS40 Europe PMC30
2013 Al-Azri, A., Gibson, R., Keefe, D., & Logan, R. (2013). Matrix metalloproteinases: do they play a role in mucosal pahology of the oral cavity?. Oral Diseases, 19(4), 347-359.
DOI Scopus21 WoS16 Europe PMC15
2013 Qutob, A., Allen, G., Gue, S., Revesz, T., Logan, R., & Keefe, D. (2013). Implementation of a hospital oral care protocol and recording of oral mucositis in children receiving cancer treatment: a retrospective and a prospective study. Supportive Care in Cancer, 21(4), 1113-1120.
DOI Scopus37 WoS34 Europe PMC27
2013 Stringer, A., Al-Dasooqi, N., Bowen, J., Tan, T., Radzuan, M., Logan, R., . . . Gibson, R. (2013). Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases. Supportive Care in Cancer, 21(7), 1843-1852.
DOI Scopus120 WoS114 Europe PMC104
2013 Qutob, A., Gue, S., Revesz, T., Logan, R., & Keefe, D. (2013). Prevention of oral mucositis in children receiving cancer therapy: a systematic review and evidence-based analysis. Oral Oncology, 49(2), 102-107.
DOI Scopus63 WoS58 Europe PMC45
2013 Gibson, R., Keefe, D., Lalla, R., Bateman, E., Blijlevens, N., Fijlstra, M., . . . Bowen, J. (2013). Systematic review of agents for the management of gastrointestinal mucositis in cancer patients. Supportive Care in Cancer, 21(1), 313-326.
DOI Scopus181 WoS161 Europe PMC132
2013 Bateman, E., Bowen, J., Stringer, A., Mayo, B., Plews, E., Wignall, A., . . . Keefe, D. (2013). Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model. Nutrients, 5(10), 3948-3963.
DOI Scopus9 WoS10 Europe PMC9
2013 Lang, S., Keefe, D., Schultz, T., & Pearson, A. (2013). Predictors of acute adverse events from rapid rituximab infusion. Supportive Care in Cancer, 21(8), 2315-2320.
DOI Scopus11 WoS9 Europe PMC11
2012 Bowen, J., Mayo, B., Plews, E., Bateman, E., Stringer, A., Boyle, F., . . . Keefe, D. (2012). Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea. Cancer Biology & Therapy, 13(13), 1269-1275.
DOI Scopus33 WoS32 Europe PMC33
2012 Keefe, D., & Bateman, E. (2012). Tumor control versus adverse events with targeted anticancer therapies. Nature Reviews Clinical Oncology, 9(2), 98-109.
DOI Scopus97 WoS79 Europe PMC57
2012 Niscola, P., Tendas, A., Cupelli, L., Catalano, G., Scaramucci, L., Giovannini, M., . . . Keefe, D. (2012). The prevention of oral mucositis in patients with blood cancers: current concepts and emerging landscapes. Cardiovascular and Hematological Agents in Medicinal Chemistry, 10(4), 362-375.
DOI Scopus4 Europe PMC3
2011 Bowen, J., Gibson, R., & Keefe, D. (2011). Animal models of mucositis: Implications for therapy. The Journal of Supportive Oncology, 9(5), 161-168.
DOI Scopus60 Europe PMC44
2011 Al-Dasooqi, N., Bowen, J., Gibson, R., Logan, R., Stringer, A., & Keefe, D. (2011). Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat. International Journal of Experimental Pathology, 92(5), 357-365.
DOI Scopus36 WoS32 Europe PMC28
2011 Bateman, E., & Keefe, D. (2011). Patient-reported outcomes in supportive care. Seminars in Oncology, 38(3), 358-361.
DOI Scopus15 WoS12 Europe PMC11
2011 Keefe, D., Bowen, J., Gibson, R., Tan, T., Okera, M., & Stringer, A. (2011). Noncardiac vascular toxicities of vascular endothelial growth factor inhibitors in advanced cancer: a review. The Oncologist, 16(4), 432-444.
DOI Scopus87 WoS69 Europe PMC51
2011 Al-Dasooqi, N., Bowen, J., Gibson, R., Logan, R., Stringer, A., & Keefe, D. (2011). Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis. Chemotherapy, 57(1), 43-53.
DOI Scopus15 WoS16 Europe PMC14
2010 Al-Dasooqi, N., Gibson, R., Bowen, J., Logan, R., Stringer, A., & Keefe, D. (2010). Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat. Experimental Biology and Medicine (Maywood), 235(10), 1244-1256.
DOI Scopus59 WoS50 Europe PMC49
2010 Ong, Z., Gibson, R., Bowen, J., Stringer, A., Darby, J., Logan, R., . . . Keefe, D. (2010). Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis. Radiation Oncology, 5(22), 1-8.
DOI Scopus125 WoS114 Europe PMC99
2010 Bowen, J., Tsykin, A., Stringer, A., Logan, R., Gibson, R., & Keefe, D. (2010). Kinetics and regional specificity of irinotecan-induced gene expression in the gastrointestinal tract. Toxicology, 269(1), 1-12.
DOI Scopus11 WoS8 Europe PMC9
2010 Keefe, D., & Bateman, E. (2010). Gastrointestinal toxicity of targeted anti-cancer therapy. Treatment Stragegies Oncology, 2010, 224-227.
2010 Lalla, R., Pilbeam, C., Walsh, S., Sonis, S., Keefe, D., & Peterson, D. (2010). Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study. Supportive Care in Cancer, 18(1), 95-103.
DOI Scopus44 Europe PMC31
2010 Al-Dasooqi, N., Gibson, R., Bowen, J., Logan, R., Stringer, A., & Keefe, D. (2010). Matrix metalloproteinases and their inhibitors are altered in a time-course model of irinotecan-induced mucositis. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 25(s3), A2.
DOI
2010 Keefe, D., & Stringer, A. (2010). The potential successes and challenges of targeted anticancer therapies. Current opinion in supportive and pallative care, 4(1), 16-18.
DOI Scopus4 Europe PMC4
2009 Aprile, G., Ramoni, M., Keefe, D., & Sonis, S. (2009). Links between regimen-related toxicities in patients being treated for colorectal cancer. Current opinion in supportive and pallative care, 3(1), 50-54.
DOI Scopus15 Europe PMC14
2009 Keefe, D. M. (2009). Mucositis and lung cancer. JOURNAL OF THORACIC ONCOLOGY, 4(9), S36.
2009 Stringer, A. M., Gibson, R. J., Bowen, J. M., Logan, R. M., Al-Dasooqi, N., & Keefe, D. M. K. (2009). The importance of the gut microbiome in gastrointestinal mucositis. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24, A237.
2009 Al-Dasooqi, N., Bowen, J., Gibson, R., Sullivan, T., Lees, J., & Keefe, D. (2009). Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients. Investigational New Drugs, 27(2), 173-178.
DOI Scopus29 WoS22 Europe PMC17
2009 Al-Dasooqi, N., Gibson, R., Bowen, J., & Keefe, D. (2009). HER2 targeted therapies for cancer and the gastrointestinal tract. Current Drug Targets, 10(6), 537-542.
DOI Scopus19 WoS20 Europe PMC13
2009 Al-Dasooqi, N., Gibson, R., Bowen, J., & Keefe, D. (2009). Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?. Cancer Chemotherapy and Pharmacology, 64(1), 1-9.
DOI Scopus40 WoS40 Europe PMC29
2009 Stringer, A., Gibson, R., Logan, R., Bowen, J., Yeoh, A., Hamilton, J., & Keefe, D. (2009). Gastrointestinal Microflora and Mucins May Play a Critical Role in the Development of 5-Fluorouracil-Induced Gastrointestinal Mucositis. Experimental Biology and Medicine (Maywood), 234(4), 430-441.
DOI Scopus199 WoS183 Europe PMC153
2009 Stringer, A., Gibson, R., Bowen, J., & Keefe, D. (2009). Chemotherapy-induced modifications to gastrointestinal microflora: Evidence and implications of change. Current Drug Metabolism, 10(1), 79-83.
DOI Scopus98 WoS86 Europe PMC76
2009 Stringer, A., Gibson, R., Bowen, J., Logan, R., Ashton, K., Yeoh, A., . . . Keefe, D. (2009). Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile. International Journal of Experimental Pathology, 90(5), 489-499.
DOI Scopus136 WoS123 Europe PMC109
2009 Stringer, A., Gibson, R., Logan, R., Bowen, J., Yeoh, A., Laurence, J., & Keefe, D. (2009). Irinotecan-induced mucositis is associated with changes in intestinal mucins. Cancer Chemotherapy and Pharmacology, 64(1), 123-132.
DOI Scopus77 WoS73 Europe PMC69
2009 Logan, R., Stringer, A., Bowen, J., Gibson, R., Sonis, S., & Keefe, D. (2009). Is the pathobiology of chemotherapy-induced alimentary tract mucositis inXuenced by the type of mucotoxic drug administered?. Cancer Chemotherapy and Pharmacology, 63(2), 239-251.
DOI Scopus144 WoS132 Europe PMC113
2008 Aprile, G., Ramoni, M., Keefe, D., & Sonis, S. (2008). Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy. Cancer, 112(2), 284-292.
DOI Scopus56 WoS42 Europe PMC48
2008 Keefe, D., & Prowse, R. (2008). Geriatric oncology: A medical sub-specialty whose time has come. Cancer Forum, 32(1), 3-5.
Scopus2 WoS2
2008 Elting, L., Keefe, D., Sonis, S., Garden, A., Spijkervet, F., Barasch, A., . . . Vera-Llonch, M. (2008). Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: Demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer, 113(10), 2704-2713.
DOI Scopus309 WoS260 Europe PMC226
2008 Niscola, P., Scaramucci, L., Romani, C., Cupelli, L., Tendas, A., Dentamaro, T., . . . de Fabritiis, P. (2008). Mucositis in the treatment of haematological malignancies. Annals of Oncology, 19(Supp 7), 141-145.
DOI Scopus6 WoS6 Europe PMC3
2008 Keefe, D., Sonis, S., & Bowen, J. (2008). Emerging drugs for chemotherapy-induced mucositis. Expert Opinion on Emerging Drugs, 13(3), 511-522.
DOI Scopus44 WoS39 Europe PMC28
2008 Logan, R., Stringer, A., Bowen, J., Gibson, R., Sonis, S., & Keefe, D. (2008). Serum levels of NF kappa B and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biology & Therapy, 7(7), 1139-1145.
DOI Scopus165 WoS142 Europe PMC125
2008 Gibson, R., Bowen, J., & Keefe, D. (2008). Technological advances in mucositis research: New insights and new issues. Cancer Treatment Reviews, 34(5), 476-482.
DOI Scopus17 WoS15 Europe PMC8
2008 Bowen, J., & Keefe, D. (2008). New pathways for alimentary mucositis. Journal of Oncology, 2008(907892), 1-7.
DOI WoS21 Europe PMC10
2008 Stringer, A., Gibson, R., Logan, R., Bowen, J., Yeoh, A., & Keefe, D. (2008). Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats. Cancer Biology & Therapy, 7(12), 1919-1925.
DOI Scopus178 WoS157 Europe PMC143
2008 Logan, R., Gibson, R., Bowen, J., Stringer, A., Sonis, S., & Keefe, D. (2008). Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis. Cancer Chemotherapy and Pharmacology, 62(1), 33-41.
DOI Scopus164 WoS150 Europe PMC145
2008 Keefe, D., & Anthony, L. (2008). Tyrosine kinase inhibitors and gut toxicity: A new era in supportive care. Current Opinion in Supportive and Palliative Care, 2(1), 19-21.
DOI Scopus12 Europe PMC10
2008 Barasch, A., Spijkervet, F., Garden, A., Kudrimoti, M. R., Brachman, D., Brennan, M., . . . Sonis, S. (2008). Efficacy of opioid analgesics and effect on functional status of pain caused by radiation-induced mucositis among patients with head and neck cancer. JOURNAL OF CLINICAL ONCOLOGY, 26(15), 1 page.
DOI WoS2
2008 Niscola, P., Scaramucci, L., Romani, C., Cupelli, L., Tendas, A., Dentamaro, T., . . . de Fabritiis, P. (2008). Erratum: Mucositis in the treatment of haematological malignancies (Annals of Oncology (2008) vol. 19 (vii141-vii145)). Annals of Oncology, 19(11), 1982.
DOI
2007 Keefe, D. M. K. (2007). Supportive care silos: time to forge cross-links, using mucositis as an example.. Current Opinion in Supportive and Palliative Care, 1(1), 40-42.
DOI Scopus2 Europe PMC2
2007 Logan, R., Gibson, R., Sonis, S., & Keefe, D. (2007). Nuclear factor-κ B (NF-κ B) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncology, 43(4), 395-401.
DOI Scopus142 WoS122 Europe PMC114
2007 Keefe, D., Schubert, M., Elting, L., Sonis, S., Epstein, J., Raber-Durlacher, J., . . . Peterson, D. (2007). Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer, 109(5), 820-831.
DOI Scopus665 WoS530 Europe PMC448
2007 Bowen, J., Gibson, R., Stringer, A., Chan, T., Prabowo, A., Cummins, A., & Keefe, D. (2007). Role of p53 in irinotecan-induced intestinal cell death and mucosal damage. Anti-Cancer Drugs, 18(2), 197-210.
DOI Scopus24 WoS21 Europe PMC21
2007 Stringer, A., Gibson, R., Logan, R., Bowen, J., Yeoh, A., Burns, J., & Keefe, D. (2007). Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat. Experimental Biology and Medicine (Maywood), 232(1), 96-106.
Scopus98 WoS83 Europe PMC55
2007 Jones, A., Wilson, I., & Keefe, D. (2007). Developing a Process of Continuous Quality Improvement in Medical School Assessment Processes: Lessons from One School. Focus on Health Professional Education, 9(2), 39-46.
2007 Bowen, J., Stringer, A., Gibson, R., Yeoh, A., Hannam, S., & Keefe, D. (2007). VSL#3 probiotic treatment reduces chemotherapy-induced diarrhoea and weight loss. Cancer Biology & Therapy, 6(9), 1449-1454.
DOI Scopus189 WoS169 Europe PMC138
2007 Keefe, D., Rassias, G., O'Neil, L., & Gibson, R. (2007). Severe mucositis: How can nutrition help?. Current Opinion in Clinical Nutrition and Metabolic Care, 10(5), 627-631.
DOI Scopus21 WoS21 Europe PMC18
2007 Stringer, A., Gibson, R., Bowen, J., Logan, R., Yeoh, A., & Keefe, D. (2007). Chemotherapy-induced mucositis: The role of gastrointestinal microflora and mucins in the luminal environment. The Journal of Supportive Oncology, 5(6), 259-267.
Scopus72 Europe PMC48
2007 Bowen, J., Gibson, R., Cummins, A., Tyskin, A., & Keefe, D. (2007). Irinotecan changes gene expression in the small intestine of the rat with breast cancer. Cancer Chemotherapy and Pharmacology, 59(3), 337-348.
DOI Scopus38 WoS34 Europe PMC30
2007 Duggan, P., & Keefe, D. (2007). Paid term-time employment in undergraduate medical students at the University of Adelaide. Focus on Health Professional Education, 19(1), 58-66.
2007 Logan, R., Stringer, A., Bowen, J., Yeoh, A., Gibson, R., Sonis, S., & Keefe, D. (2007). The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: Pathobiology, animal models and cytotoxic drugs. Cancer Treatment Reviews, 33(5), 448-460.
DOI Scopus246 WoS223 Europe PMC193
2007 Bowen, J., Gibson, R., Tsykin, A., Stringer, A., Logan, R., & Keefe, D. (2007). Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy. International Journal of Cancer, 121(8), 1847-1856.
DOI Scopus41 WoS39 Europe PMC36
2007 Yeoh, A., Gibson, R., Yeoh, E., Bowen, J., Stringer, A., Giam, K., & Keefe, D. (2007). A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis p53 nuclear factor-kappa B COX-1 and COX-2. Molecular Cancer Therapeutics, 6(8), 2319-2327.
DOI Scopus53 WoS46 Europe PMC44
2007 Gibson, R., Stringer, A., Bowen, J., Logan, R., Yeoh, A., Burns, J., . . . Keefe, D. (2007). Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats. Cancer Biology & Therapy, 6(4), 541-547.
DOI Scopus16 WoS14 Europe PMC10
2007 Keefe, D. (2007). Intestinal mucositis: mechanisms and management. Current Opinion in Oncology, 19(4), 323-327.
DOI Scopus76 WoS65 Europe PMC56
2007 Joshi, R., Olver, I., Keefe, D., Marafioti, T., & Smith, K. (2007). A phase I study to assess the safety and activity of topical lovastatin (FP252S) for the prevention of chemotherapy-induced alopecia. Supportive Care in Cancer, 15(9), 1109-1112.
DOI Scopus8 WoS5 Europe PMC4
2007 Gibson, R., Bowen, J., Alvarez, E., Finnie, J., & Keefe, D. (2007). Establishment of a Single-Dose Irinotecan Model of Gastrointestinal Mucositis. Chemotherapy, 53(5), 360-369.
DOI Scopus60 WoS47 Europe PMC43
2007 Keefe, D., & Gibson, R. (2007). Mucosal injury from targeted anti-cancer therapy. Supportive Care in Cancer, 15(5), 483-490.
DOI Scopus45 WoS33 Europe PMC28
2006 Gibson, R., & Keefe, D. (2006). Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies. Supportive Care in Cancer, 14(9), 890-900.
DOI Scopus201 WoS163 Europe PMC140
2006 Keefe, D., Lees, J., & Horvath, N. (2006). Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience. Supportive Care in Cancer, 14(6), 580-582.
DOI Scopus24 WoS25 Europe PMC17
2006 Lalla, R., Schubert, M., Bensadoun, R., & Keefe, D. (2006). Anti-inflammatory agents in the management of alimentary mucositis. Supportive Care in Cancer, 14(6), 558-565.
DOI Scopus66 WoS49 Europe PMC39
2006 Bensadoun, R., Schubert, M., Lalla, R., & Keefe, D. (2006). Amifostine in the management of radiation-induced and chemo-induced mucositis. Supportive Care in Cancer, 14(6), 566-572.
DOI Scopus58 WoS47 Europe PMC41
2006 Peterson, D., Keefe, D., Hutchins, R., & Schubert, M. (2006). Alimentary tract mucositis in cancer patients: impact of terminology and assessment on research and clinical practice. Supportive Care in Cancer, 14(6), 499-504.
DOI Scopus33 WoS23 Europe PMC24
2006 Brennan, M., von Bultzingslowen, I., Schubert, M., & Keefe, D. (2006). Alimentary mucositis: putting the guidelines into practice. Supportive Care in Cancer, 14(6), 573-579.
DOI Scopus13 WoS10 Europe PMC11
2006 von Bultzingslowen, I., Brennan, M., Spijkervet, F., Logan, R., Stringer, A., Raber-Durlacher, J., & Keefe, D. (2006). Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis. Supportive Care in Cancer, 14(6), 519-527.
DOI Scopus62 WoS52 Europe PMC44
2006 Keefe, D., Peterson, D., & Schubert, M. (2006). Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls. Supportive Care in Cancer, 14(6), 492-498.
DOI Scopus22 WoS18 Europe PMC17
2006 Bowen, J., Gibson, R., Cummins, A., & Keefe, D. (2006). Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Supportive Care in Cancer, 14(7), 713-731.
DOI Scopus102 WoS95 Europe PMC81
2006 Keefe, D. (2006). Supportive care in colon cancer. Supportive Cancer Therapy, 3(3), 171-172.
DOI
2006 Gibson, R., Cummins, A., Bowen, J., Logan, R., Healey, T., & Keefe, D. (2006). Apoptosis occurs early in the basal layer of the oral mucosa following cancer chemotherapy. Asia Pacific Journal of Clinical Oncology, 2(1), 39-49.
DOI Scopus25
2006 Keefe, D., & Gibson, R. (2006). The combination of oral and small intestinal mucositis, pediatrics and biomarkers - A particularly tricky problem!. Cancer Biology & Therapy, 5(10), 1282-1284.
DOI Scopus8 WoS8 Europe PMC10
2006 Keefe, D., & Gibson, R. (2006). Sucrose breath testing and intestinal mucositis. Cancer Biology & Therapy, 5(9), 1196-1198.
DOI Scopus6 WoS5 Europe PMC4
2006 Keefe, D. (2006). Mucositis guidelines: what have they achieved, and where to from here?. Supportive Care in Cancer, 14(6), 489-491.
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2006 Yeoh, A., Gibson, R., Yeoh, E., Bowen, J., Stringer, A., Giam, K., . . . Keefe, D. (2006). Radiation therapy-induced mucositis: Relationships between fractionated radiation, NF-kappa B, COX-1, and COX-2. Cancer Treatment Reviews, 32(8), 645-651.
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2006 Pittman, K., Olver, I., Koczwara, B., Kotasek, D., Patterson, W., Keefe, D., . . . Price, T. (2006). Gemcitabine and carboplatin in carcinoma of unknown primary site: a phase 2 Adelaide Cancer Trials and Education Collaborative study. British Journal of Cancer, 95(10), 1309-1313.
DOI Scopus32 WoS30 Europe PMC26
2006 Keefe, D. (2006). Mucositis management in patients with cancer. Supportive Cancer Therapy, 3(3), 154-157.
DOI Scopus17 Europe PMC9
2006 Bowen, J. M., Gibson, R. J., Cummins, A. G., Tyskin, A., & Keefe, D. M. K. (2006). Irinotecan-induced changes in gene expression in the small intestine of the rat with cancer. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 21, A275.
2006 Stringer, A. M., Gibson, R. J., Logan, R. M., Bowen, J. M., Yeoh, A. S. J., & Keefe, D. M. K. (2006). Chemotherapy-induced changes in mucin secretion and composition. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 21, A266.
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2006 Yeoh, A., Gibson, R., Yeoh, E., Bowen, J., Stringer, A., Giam, K., & Keefe, D. (2006). A novel animal model to investigate radiation-induced mucositis: a qualitative assessment of mucosal injury resulting from fractionated radiotherapy. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 21, A260.
2005 Yeoh, A., Bowen, J., Gibson, R., & Keefe, D. (2005). Nuclear factor kB (NFkB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes. International Journal of Radiation Oncology Biology Physics, 63(5), 1295-1303.
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2005 Olver, I., Keefe, D., Myers, M., & Caruso, D. (2005). A phase I study of prolonged ambulatory infusion of ifosfamide with oral mesna. Chemotherapy, 51(2-3), 142-146.
DOI Scopus3 WoS2 Europe PMC2
2005 Gibson, R., Bowen, J., Cummins, A., & Keefe, D. (2005). Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat. Clinical and Experimental Medicine, 4(4), 188-195.
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2005 Gibson, R., Bowen, J., & Keefe, D. (2005). Palifermin reduces diarrhea and increases survival following Irinotecan treatment in tumor-bearing DA rats. International Journal of Cancer, 116(3), 464-470.
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2005 Olver, I., Keefe, D., & Myers, M. (2005). Phase II study of prolonged ambulatory infusion carboplatin and oral etoposide for patients progressing through hormonal therapy for prostate cancer. Internal Medicine Journal, 35(7), 405-408.
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2005 Bowen, J., Gibson, R., Keefe, D., & Cummins, A. (2005). Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans. Pathology, 37(1), 56-62.
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2004 Keefe, D. (2004). Gastrointestinal mucositis: a new biological model. Supportive Care in Cancer, 12(1), 6-9.
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2004 Elting, L., Keefe, D., & Sonis, S. (2004). Treatment-Induced Gastrointestinal Toxicity in Patients With Cancer. Educational Book, 536-541.
2004 Peterson, D., Beck, S., & Keefe, D. (2004). Novel therapies. Seminars in Oncology Nursing, 20(1), 53-58.
DOI Scopus12 Europe PMC9
2004 Keefe, D., Gibson, R., & Hauer-Jensen, M. (2004). Gastrointestinal mucositis. Seminars in Oncology Nursing, 20(1), 38-47.
DOI Scopus100 Europe PMC77
2004 Sonis, S., Elting, L., Keefe, D., Peterson, D., Schubert, M., Hauer-Jensen, M., . . . Donelly, J. (2004). Perspectives on cancer therapy-induced mucosal injury : Pathogenesis, measurement, epidemiology, and consequences for patients. Cancer, 100(s9), 1995-2025.
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2004 Rubenstein, E., Peterson, D., Schubert, M., Keefe, D., McGuire, D., Epstein, J., . . . Sonis, S. (2004). Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer, 100(s9), 2026-2046.
DOI Scopus676 WoS532 Europe PMC449
2003 Gibson, R., Bowen, J., Inglis, M., Cummins, A., & Keefe, D. (2003). Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer. Journal of Gastroenterology and Hepatology, 18(9), 1095-1100.
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2002 Gibson, R., Keefe, D., Thompson, F., Clarke, J., Goland, G., & Cummins, A. (2002). Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats. Digestive Diseases and Sciences, 47(12), 2751-2757.
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2002 Gibson, R., Keefe, D., Clarke, J., Regester, G., Thompson, F., Goland, G., . . . Cummins, A. (2002). The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer. Cancer Chemotherapy and Pharmacology, 50(1), 53-58.
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2002 Olver, I., Hercus, T., Lopez, A., Vadas, M., Somogyi, A., Doyle, I., . . . Wigley, P. (2002). A phase I study of the GM-CSF antagonist E21R. Cancer Chemotherapy and Pharmacology, 50(3), 171-178.
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2000 Parnis, F., Olver, I., Kotasek, D., Norman, J., Taylor, A., Russell, J., . . . Marafioti, T. (2000). Phase II study of epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF) for carcinoma of unknown primary site. Annals of Oncology, 11(7), 883-884.
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2000 Keefe, D., Brealey, J., Goland, G., & Cummins, A. (2000). Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut, 47(5), 632-637.
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1999 Basser, R., To, L., Collins, J., Begley, C., Keefe, D., Cebon, J., . . . Green, M. (1999). Multicycle high-dose chemotherapy and filgrastim-mobilized peripheral-blood progenitor cells in women with high-risk stage ii or iii breast cancer: five-year follow-up. Journal of Clinical Oncology, 17(1), 82-92.
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1999 Keefe, D. M. K., Bell, D., Wheeler, H., & Ma, D. D. F. (1999). Severe adverse reaction to high dose epirubicin and cyclophosphamide for poor prognosis breast cancer [4]. Australian and New Zealand Journal of Medicine, 29(2), 275-277.
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1997 Keefe, D., Cummins, A., Dale, B., Kotasek, D., Robb, T., & Sage, R. (1997). Effect of high-dose chemotherapy on intestinal permeability in humans.. Clinical Science, 92(4), 385-389.
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1994 PATTERSON, W. K., SAGE, R. E., & KEEFE, D. M. (1994). Haemorrhagic gastritis in two patients treated with all‐trans‐retinoic acid in acute promyelocytic leukaemia. Australian and New Zealand Journal of Medicine, 24(3), 314-315.
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Year Citation
2013 Sonis, S., & Keefe, D. (Eds.) (2013). Pathobiology of cancer regimen-related toxicities. United States: Springer.
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2013 Sonis, S., & Keefe, D. (Eds.) (2013). Pathobiology of cancer regimen-related toxicities. United States: Springer.
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2013 Al-Dasooqi, N., Keefe, D. M., & Sonis, S. T. (2013). Mucositis.
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2013 Al-Dasooqi, N., Keefe, D. M., & Sonis, S. T. (2013). Mucositis.
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2013 Sonis, S. T., & Keefe, D. M. (2013). Preface.
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2013 Sonis, S. T., & Keefe, D. M. (2013). Preface.
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2013 Sonis, S. T., & Keefe, D. M. (2013). Conclusion.
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2013 Sonis, S. T., & Keefe, D. M. (2013). Conclusion.
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Year Citation
2024 Webb, S., Rahal, R., Salemi, L., Cernigoy, M., Pfefferle, T., Louzado, C., . . . Keefe, D. (2024). Cancer Control Agencies in Australia, Aotearoa New Zealand, and Canada. In Indigenous and Tribal Peoples and Cancer (pp. 53-57). Springer Nature Switzerland.
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2024 Elston, J., Whop, L., Nehill, C., & Keefe, D. (2024). Providing Leadership in Developing National Cancer Control Policy in Australia. In Indigenous and Tribal Peoples and Cancer (pp. 47-52). Springer Nature Switzerland.
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2024 Falzon, K., Johnson, K., Salisbury, J., & Keefe, D. (2024). Our Mob and Cancer. In Indigenous and Tribal Peoples and Cancer (pp. 107-110). Springer Nature Switzerland.
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2024 Denning, W., Nehill, C., Elston, J., & Keefe, D. (2024). Yarn for Life: Improving Cancer Outcomes Through a National Communication Campaign. In Indigenous and Tribal Peoples and Cancer (pp. 103-106). Springer Nature Switzerland.
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2019 Bateman, E., Logan, R., Gibson, R., & Keefe, D. (2019). Mucositis. In Textbook of Palliative Care (pp. 317-333). Springer International Publishing.
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2019 Bateman, E., Logan, R., Gibson, R., & Keefe, D. (2019). Mucositis. In R. MacLeod, & L. Van den Block (Eds.), Textbook of Palliative Care (pp. 1-17). Switzerland: Springer Cham.
2013 Lyng, G., Logan, R., & Mancini, M. (2013). Animal models of regimen-related toxicities. In Pathobiology of Cancer Regimen Related Toxicities (pp. 75-95).
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2013 Lyng, G., Logan, R., & Mancini, M. (2013). Animal models of regimen-related toxicities. In Pathobiology of Cancer Regimen Related Toxicities (pp. 75-95).
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2013 Al-Dasooqi, N., Keefe, D., & Sonis, S. (2013). Mucositis. In S. Sonis, & D. Keefe (Eds.), Pathobiology of Cancer Regimen-Related Toxicities (1 ed., pp. 121-146). United States: Springer.
2013 Gibson, R., Bowen, J., Bateman, E., & Keefe, D. (2013). Biology of treatment-induced mucositis. In A. Berger, J. Shuster, & J. Von Roenn (Eds.), Principles and practice of palliative oncology and supportive oncology (4th ed., pp. 238-246). US: Lippincott Williams & Wilkins.
2012 Al-Dasooqi, N., Gibson, R., Bowen, J., & Keefe, D. (2012). HER2 targeted therapy-induced gastrointestinal toxicity: from the clinical experience to possible molecular mechanisms. In D. Whitehouse, & R. Rapley (Eds.), Molecular and Cellular Therapeutics (1 ed., pp. 69-102). United Kingdom: Wiley.
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2011 Paternotte, D., Tremblay, M., & Johnson, C. (2011). Conclusion. In M. Tremblay, D. Paternotte, & C. Johnson (Eds.), The Lesbian and Gay Movement and the State: Comparative Insights into a Transformed Relationship (1 ed., pp. 213-227). United Kingdom: Ashgate Publishing Limited.
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2011 Paternotte, D., Tremblay, M., & Johnson, C. (2011). Conclusion. In M. Tremblay, D. Paternotte, & C. Johnson (Eds.), The Lesbian and Gay Movement and the State: Comparative Insights into a Transformed Relationship (1 ed., pp. 213-227). United Kingdom: Ashgate Publishing Limited.
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2008 Keefe, D., Bowen, J., & Gibson, R. (2008). Use of project teams in preclinical development. In S. Gad (Ed.), Preclinical Development Handbook: Toxicology (pp. 65-80). USA and Canada: Wiley.
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2008 Gibson, R., Bowen, J., & Keefe, D. (2008). Relationship between animal models and clinical research: using mucositis as a practical example. In S. Gad (Ed.), Preclinical Development Handbook: Toxicology (pp. 81-101). USA and Canada: Wiley.
DOI Scopus1

Year Citation
2022 Milch, V., Anderson, K., Farrugia, T., Boltong, A., & Keefe, D. (2022). Early design and feasibility assessment of a potential Lung Cancer Screening Program in Australia. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 18 (pp. 85). WILEY.
2022 McNeill, S., Hanson, S., Elston, J., Boltong, A., & Keefe, D. (2022). Embedding equity in the Australian Cancer Plan: Engaging priority populations to improve equitable outcomes for all Australians. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 18 (pp. 101). WILEY.
2022 Moroney, D., Lucas, K., Nehill, C., Williams, D., Mor, S., Keefe, D., & Boltong, A. (2022). A communication skills module for non-Indigenous health care professionals supporting Aboriginal and Torres Strait Islander people with cancer. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 18 (pp. 109). WILEY.
2022 Chaji, D., Austen, M., Cox, R., Der Vartanian, C., Boltong, A., & Keefe, D. (2022). The Australian Cancer Plan: A decision tree approach for assessment against International Standards of National Cancer Control Planning. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 18 (pp. 100). WILEY.
2022 Keefe, D., Cox, R., Vartanian, C. D., Lambert, A., & Boltong, A. (2022). Shaping the future of cancer control - The Australian cancer plan. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 18 (pp. 84). WILEY.
2021 Biondi, C., Milch, V., Nguyen, V., Ryan, R., Roder, D., Woods, A., . . . Keefe, D. M. K. (2021). The COVID-19 pandemic led to a reduction in cancer services in Australia.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 39 (pp. 3 pages). ELECTR NETWORK: LIPPINCOTT WILLIAMS & WILKINS.
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2021 Biondi, C., Milch, V., Nguyen, V., Ryan, R., Roder, D., Woods, A., . . . Keefe, D. (2021). Understanding the impact of the pandemic on cancer services in Australia. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 17 (pp. 35). WILEY.
2020 Biondi, C., Nguyen, V., Milch, V., Roder, D., Woods, A., Anderiesz, C., & Keefe, D. (2020). Measuring the impact of COVID-19 on cancer services using the Medicare Benefits Schedule (MBS). In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 16 (pp. 91-92). WILEY.
2019 Bowen, J. M., Secombe, K. R., Ball, I. A., Shirren, J., Wignall, A. D., Finnie, J. W., . . . Keefe, D. (2019). Budesonide and colesevelam reduce neratinib-induced diarrhea in a rat model. In CANCER RESEARCH Vol. 79 (pp. 2 pages). San Antonio, TX: AMER ASSOC CANCER RESEARCH.
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2018 Korver, S. K., Bowen, J. M., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R., . . . Coller, J. K. (2018). Personalised supportive care for patients receiving 5-fluorouracil (5-FU): analysis of multivariate SNP risk prediction for GI toxicity. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 14 (pp. 58-59). WILEY.
2015 Wan Mohamad Zain, W., Bowen, J., Bateman, E., & Keefe, D. (2015). Investigation of lapatinib-induced diarrhea in a tumour-bearing rat model. In Supportive Care in Cancer Vol. 23 (pp. S387). Copenhagen, Denmark: Springer Verlag (Germany).
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2015 Vanhoecke, B., Mayo, B., Wignall, A., Ziegler, V., Stringer, A., Bateman, E., . . . Keefe, D. (2015). Irinotecan induces DNA damage in the oral cavitiy of the Dark Agouti rats without visual signs of lesions. In Supportive Care in Cancer Vol. 23 (pp. S115). Copenhagen, Denmark: Springer Verlag (Germany).
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2015 Mayo, B., Stringer, A., Lucchesi, C., Bowen, J., Bateman, E., Wignall, A., . . . Keefe, D. (2015). Microbial alterations and toll-like receptor expression play a role in the improvement of irinotecan-induced mucositis after treatment with the new selective GLP-2 receptor agonist, Elsiglutide. In Supportive Care in Cancer Vol. 23 (pp. S111). Copenhagen, Denmark: Springer Verlag (Germany).
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2015 Ruhlmann, C. H., Christensen, T. B., Dohn, L. H., Paludan, M., Ronnengart, E., Hilpert, F., . . . Herrstedt, J. (2015). Fosaprepitant for the prevention of nausea and emesis during five weeks of chemo-radiotherapy: A multinational randomised, placebo-controlled, double-blind trial - the GAND-emesis study. In EUROPEAN JOURNAL OF CANCER Vol. 51 (pp. S727). Vienna, AUSTRIA: ELSEVIER SCI LTD.
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2014 MASCC 2014 (2014). In Supportive Care in Cancer Vol. 22 (pp. 1-238). Springer Science and Business Media LLC.
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2013 Al-Azri, A. S., Logan, R., Gibson, R., Keefe, D., stringer, A., & Bowen, J. (2013). The role of matrix metalloproteinases and tissue inhibitors of metalloproteinase in irinotecan induced-chemotherapy. In Supportive Care in Cancer. Berlin Genrmany: Springer Verlag (Germany).
2013 Abstracts of the MASCC/ISOO (Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology) International Symposium on Supportive Care in Cancer. June 27-29, 2013. Berlin, Germany. (2013). In Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Vol. 21 Suppl 1 (pp. S2-301). Germany: Springer Science and Business Media LLC.
DOI Europe PMC2
2012 Abstracts of the 2012 International MASCC/ISOO (Multiple Association of Supportive Care in Cancer/International Society for Oral Oncology) Symposium. New York City, New York, USA. June 28-30, 2012. (2012). In Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Vol. 20 Suppl 1 (pp. 1-283). Germany: Springer Science and Business Media LLC.
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2012 Peterson, D., Keefe, D., & Sonis, S. (2012). New frontiers in mucositis. In R. Govindan (Ed.), American Society of Clinical Oncology 2012 Educational Book (pp. 545-551). Chicago, Illinois: American Society of Clinical Oncology.
DOI Europe PMC12
2011 Gibson, R., Mahmud, F., Bowen, J., Yeoh, A., Logan, R., & Keefe, D. (2011). Inhibition of NFkB ameliorates long term radiation-induced mucositis. In Proceedings of the 38th COSA Annual Scientific Meeting 2011 Vol. 7 (pp. 110-111). United Kingdom: Blackwell Publishing Ltd..
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2011 Keefe, D., & Bateman, E. (2011). Supportive care in cancer: developments in treatment and symptom management. In 49th Annual Meeting of Japanese Society of Clinical Oncology (pp. 0 pages). Nagoya Conference Centre, Japan: Japanese Society of Clinical Oncology.
2011 Al-Dasooqi, N., Mayo, B., Bowen, J., Stringer, A., Gibson, R., & Keefe, D. (2011). Pilot study of biomarkers of chemotherapy-induced Gastrointestinal Toxicity. In Proceedings of the COSA Annual Scientific Meeting Vol. 7 (pp. 1). United Kingdom: Blackwell Publishing Ltd..
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2011 Stringer, A., Gibson, R., Yeoh, A., Bowen, J., & Keefe, D. (2011). Chemotherapy-induced diarrhoea is associated with a modified intestinal microbiome and intestinal inflammation. In Abstracts of the 2011 International MASCC/ISOO Symposium Vol. 19 (pp. 153). 175 Fifth Ave New York NY 10010: Springer-Verlag.
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2011 Mayo, B., Bowen, J., Stringer, A., Bateman, E., Plews, E., Darby, J., . . . Keefe, D. (2011). The effect of ErbB inhibition on chemotherapy-induced intestinal damage. In Abstracts of the 2011 International MASCC/ISOO Symposium Vol. 19 (pp. 0 pages). 175 Fifth Ave New York NY 10010: Springer-Verlag.
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2011 Elting, L., Lei, X., Nguyen, H., Keefe, D., & Sonis, S. (2011). Risk of patient-reported oral mucositis during chemotherapy for colorectal cancer (CRC): do multiple cycles multiply risk?. In Abstracts of the 2011 International MASCC/ISOO Symposium Vol. 19 (pp. 0 pages). 175 Fifth Ave New York NY 10010: Springer-Verlag.
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2010 Al-Dasooqi, N., Bowen, J., Gibson, R., Logan, R., Stringer, A., & Keefe, D. (2010). Irinotecan-induced mucositis encompasses changes in intestinal and colonic cell kinetics and this is associated with altered extracellular matrix component expression. In Abstracts of the 2010 International MASCC/ISOO Symposium Vol. 25 (pp. 0 pages). Vancouver, Canada: Springer-Verlag.
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2010 Al-Dasooqi, N., Gibson, R., Bowen, J., Logan, R., Stringer, A., & Keefe, D. (2010). Matrix metalloproteinases play a pivotal role in the development of alimentary tract mucositis. In Sydney Cancer Conference (pp. 0 pages). The University of Sydney, NSW, Australia.
2010 Ruhlmann, C. H., Iversen, T. Z., Okera, M., Muhic, A., Hjelmtvedt, A., Feyer, P., . . . Herrstedt, J. (2010). IDENTIFICATION AND RANKING OF SIDE-EFFECTS IN PATIENTS RECEIVING RADIOTHERAPY AND CONCOMITANT WEEKLY CISPLATIN. A MULTINATIONAL COLLABORATIVE SURVEY. In ANNALS OF ONCOLOGY Vol. 21 (pp. 382). Milan, ITALY: OXFORD UNIV PRESS.
2010 Keefe, D. M. K. (2010). GASTROINTESTINAL TOXICITY. In ANNALS OF ONCOLOGY Vol. 21 (pp. 34). Milan, ITALY: OXFORD UNIV PRESS.
2009 Stringer, A., Gibson, R., Yeoh, A., Bowen, J., Logan, R., & Keefe, D. (2009). CHEMOTHERAPY-INDUCED DIARRHOEA IS ASSOCIATED WITH A MODIFIED MICROBIOME IN GI CANCER PATIENTS. In ANNALS OF ONCOLOGY Vol. 20 (pp. 73). Barcelona, SPAIN: OXFORD UNIV PRESS.
2008 Keefe, D. M., Elting, L. S., Sonis, S. T., Garden, A., Spijkervet, F., Barasch, A., . . . Harari, P. (2008). Treatment for head and neck cancer and for lung cancer causes significant diarrhea. In INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Vol. 72 (pp. S487). Boston, MA: ELSEVIER SCIENCE INC.
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2008 Sonis, S. T., Jacquin, P., Randolph-Jackson, P., Harari, P., Grunberg, S., Liao, Z., . . . Keefe, D. (2008). Prevalence of mouth and throat soreness (MTS) in patients undergoing lung cancer treatment, with adverse impact on functional and quality of life outcomes. In INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Vol. 72 (pp. S680). Boston, MA: ELSEVIER SCIENCE INC.
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2007 Price, T. J., Morelli, L., Howarth, G. S., Webster, J., Zacharakis, B., Brooker, C., . . . Butler, R. N. (2007). Residual damage to the small intestine induced by chemotherapy can be detected and monitored using the non-invasive <SUP>13</SUP>C Sucrose Breath Test (SBT). In EJC SUPPLEMENTS Vol. 5 (pp. 152). Barcelona, SPAIN: PERGAMON-ELSEVIER SCIENCE LTD.
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2007 Logan, R., Gibson, R., Stringer, A., Bowen, J., Sonis, S., & Keefe, D. (2007). Serum levels of nuclear factor-κB and tumour necrosis factor following irinotecan administration in the Dark Agouti rat. In ORAL ONCOLOGY (pp. 211). Amsterdam, NETHERLANDS: ELSEVIER SCIENCE BV.
2007 Logan, R., Gibson, R., Stringer, A., Bowen, J., Sonis, S., & Keefe, D. (2007). Nuclear factor-KB and cyclooxygenase-2 expression in the oral mucosa following cancer chemotherapy. In ORAL ONCOLOGY (pp. 171). Amsterdam, NETHERLANDS: ELSEVIER SCIENCE BV.
2007 Aprile, G., Ramoni, M., Keefe, D., & Sonis, S. (2007). Acute toxicities in colorectal cancer (CRC) patients undergoing chemotherapy (CT): Clustering and cycle-to-cycle prediction by means of Bayesian analysis. In ANNALS OF ONCOLOGY Vol. 18 (pp. 12). Palermo, ITALY: ELSEVIER.
2007 Joshi, R., O'Neill, S., & Keefe, D. (2007). A prospective audit of inpatient medical oncology consultation patterns in a tertiary teaching hospital in South Australia. In ANNALS OF ONCOLOGY Vol. 18 (pp. 196-197). Lugano, SWITZERLAND: OXFORD UNIV PRESS.
2007 Keefe, D. M. K. (2007). Oral mucositis: pathobiology and treatment guidelines. In ORAL ONCOLOGY (pp. 50). Amsterdam, NETHERLANDS: ELSEVIER SCIENCE BV.
2007 Garden, A. S., Tishler, R. B., Araschl, A., Brennan, M. T., Harari, P. M., Kudrimoti, M. R., . . . Keefe, D. (2007). Adverse impact of mucositis on health related quality of life outcomes and resource use in head and neck cancer patients receiving radiation. In INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Vol. 69 (pp. S179-S180). Los Angeles, CA: ELSEVIER SCIENCE INC.
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2007 Elting, L. S., Calais, G., Selva, N., Brachman, D., Kudrimoti, M., Spijkervet, F., . . . Sonis, S. T. (2007). Patient-reported burden of mucosal injury (MUI): Comparison of clinician-rated MUI and patient-reported outcomes. In JOURNAL OF CLINICAL ONCOLOGY Vol. 25 (pp. 2 pages). AMER SOC CLINICAL ONCOLOGY.
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2007 Aprile, G., Ramoni, M., Keefe, D., & Sonis, S. (2007). Network analyses to define chemotherapy toxicity clusters in patients with colorectal cancer (CRC). In JOURNAL OF CLINICAL ONCOLOGY Vol. 25 (pp. 1 page). AMER SOC CLINICAL ONCOLOGY.
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2007 Keefe, D. M., Garden, A., Barasch, A., Tischler, R., Brennan, M., Trotti, A., . . . Sonis, S. (2007). Oral mucositis is associated with increased resource use among patients receiving treatment for cancers of the head and neck. In JOURNAL OF CLINICAL ONCOLOGY Vol. 25 (pp. 1 page). AMER SOC CLINICAL ONCOLOGY.
2006 Vera-Llonch, M., Sonis, S. T., Keefe, D., Elting, L., Edelsberg, J., Isitt, J., . . . Oster, G. (2006). Identifying potential mucositis-related infection resource use in solid tumor cancer patients. In ANNALS OF ONCOLOGY Vol. 17 (pp. 286). Istanbul, TURKEY: ELSEVIER.
2006 Elting, L. S., Keefe, D., Sonis, S. T., Morales, M., Molassiotis, A., Isitt, J., . . . Vera-Llonch, M. (2006). Burden of illness and economic impact of mucosal injury (MUI) in solid tumor-a multinational prospective observational study design. In ANNALS OF ONCOLOGY Vol. 17 (pp. 297). Istanbul, TURKEY: ELSEVIER.
2005 Pittman, K. B., Olver, I. N., Karapetis, C. S., Kotasek, D., Price, T. J., Patterson, W. K., . . . Greer, D. (2005). Mulicenter phase II study of gemcitabine and carboplatin combination therapy for patients with metastatic carcinoma of unknown primary site: final results.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 23 (pp. 764S). Orlando, FL: AMER SOC CLINICAL ONCOLOGY.
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Year Citation
2021 Secombe, K. R., Ball, I. A., Wignall, A. D., Bateman, E., Diala, I., Lalani, A. S., & Bowen, J. M. (2021). Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats.. Poster session presented at the meeting of CANCER RESEARCH. Philadelphia, PA: AMER ASSOC CANCER RESEARCH.
2019 Coller, J. K., Korver, S. K., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R. M., . . . Bowen, J. M. (2019). Predictors of severe gastrointestinal toxicity risk in patients treated with 5-fluorouracil-based chemotherapy: A validation study. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
2017 Ruhlmann, C. H., Christensen, T. B., Dohn, L. H., Paludan, M., Roennengart, E., Hilpert, F., . . . Herrstedt, J. (2017). Fosaprepitant reduces the impact of nausea on daily function during five weeks of chemo-radiotherapy: A sub-study of the GAND-emesis trial. Poster session presented at the meeting of ANNALS OF ONCOLOGY. Madrid, SPAIN: OXFORD UNIV PRESS.
2017 Bowen, J., Ball, I., Thompson, S., Irvine, T., Chiam, K., Hussey, D., . . . Keefe, D. (2017). Identification of Inflammatory Markers of Chemoradiotherapy-Induced Gastrointestinal Toxicity in Oesophageal Cancer. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
2017 Korver, S. K., Ball, I. A., Gibson, R. J., Logan, R. M., Karapetis, C. S., Keefe, D. M., . . . Coller, J. K. (2017). The Effect of Immune Genetic Variants on Chemotherapy-Induced Gastrointestinal Toxicity (CIGT) Risk in Patients Receiving 5-Fluorouracil. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
2017 Korver, S. K., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R. M., Richards, A., . . . Coller, J. K. (2017). Interleukin-1 Beta (<i>IL1B</i>) Genetic Variability is Predictive of Chemotherapy-Induced Gastrointestinal Toxicity (CIGT) Risk in Patients Receiving 5-Fluorouracil. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
2017 Bautista, M. J., Ahmedzai, S. H., Bouzid, K., Gibson, R., Gumara, Y., Hassan, A. A. I., . . . Wang, J. J. (2017). A framework for education and advocacy for optimal cancer pain management in resource-limited settings. Poster session presented at the meeting of Annals of Oncology. Netherlands: Elsevier.
DOI
2016 Abstracts of the MASCC/ISOO 2016 Annual Meeting. (2016). Poster session presented at the meeting of Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. Germany: Springer Science and Business Media LLC.
DOI Europe PMC1
2015 Stansborough, R. L., Bateman, E., Al-Dasooqi, N., Keefe, D., & Gibson, R. (2015). Microvascular injury and associated mediator changes occur during acute radiotherapy-induced gut toxicity. Poster session presented at the meeting of Supportive Care in Cancer. Copenhagen, Denmark: Springer Verlag (Germany).
2015 Lacouture, M. E., Keefe, D., Sonis, S. T., Giri, N., Wang, T., Reisman, A., . . . Jatoi, A. (2015). Impact of Prophylactic Doxycycline (Doxy) on Maintaining Planned Dosing of Dacomitinib (D) an Irreversible panHER Inhibitor. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. ELSEVIER SCIENCE INC.
2014 Mayo, B., Bateman, E., Stringer, A., Plews, E., Wignall, A., Wozniak, B., . . . Keefe, D. (2014). The new selective GLP-2 receptor agonist, Elsiglutide, improved irinotecan-induced diarrhoea and mucositis in the rat. Poster session presented at the meeting of Supportive Care in Cancer. Miami, USA: Springer Verlag (Germany).
2014 Mayo, B., Stringer, A., Bateman, E., Bowen, J., Pietra, C., Cantoreggi, S., & Keefe, D. (2014). Apoptosis, proliferation and inflammation are improved after treatment with the new selective GLP-2 receptor agonist, Elsiglutide, in a rat model of irinotecan-induced mucositis. Poster session presented at the meeting of Supportive Care in Cancer. Miami, USA: Springer Verlag (Germany).
2014 Keefe, D. (2014). MUCOSITIS AND ITS LINKS TO OTHER TOXICITIES IN LUNG CANCER. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL.
2014 Mayo, B., Bateman, E., Stringer, A., Plews, E., Wignall, A., Wozniak, B., . . . Keefe, D. (2014). The new selective glp-2 receptor agonist, elsiglutide, improves irinotecan-induced diarrhoea and mucositis in the rat. Poster session presented at the meeting of Asia-Pacific Journal Of Clinical Oncology. Melbourne, Vic.: Wiley.
DOI WoS1
2014 Mayo, B., Stringer, A., Bateman, E., Bowen, J., Wignall, A., Wozniak, B., . . . Keefe, D. (2014). Apoptosis, proliferation and inflammation are improved after treatment with the new selective glp-2 receptor agonist, elsiglutide, in a rat model of irinotecan-induced mucositis. Poster session presented at the meeting of Asia-Pacific Journal Of Clinical Oncology. Melbourne, Vic.: Wiley.
DOI
2014 Bessen, T., Chen, G., Street, J., Eliott, J., Karnon, J., Keefe, D., & Ratcliffe, J. (2014). What sort of follow-up services would Australian breast cancer survivors prefer if we could no longer offer long-term specialist-based care? A discrete choice experiment. Poster session presented at the meeting of Asia-Pacific Journal Of Clinical Oncology. Melbourne, Vic.: Wiley.
DOI
2014 Fan, C., Georgiou, K. R., McKinnon, R. A., Keefe, D. M., Howe, P. R., & Xian, C. J. (2014). ADVERSE EFFECTS OF COMBINATION BREAST CANCER CHEMOTHERAPY ON BONE AND BONE MARROW. Poster session presented at the meeting of OSTEOPOROSIS INTERNATIONAL. Taipei, TAIWAN: SPRINGER LONDON LTD.
2014 Benge, S., Perez, D., Sharples, K., Broom, R., Jeffery, M., Proctor, J., . . . Findlay, M. (2014). ASSESSING THE EFFICACY OF ICE-CREAM-FORMULATED IRON-SATURATED LACTOFERRIN AND ANHYDROUS MILK FAT IN PREVENTING CHEMOTHERAPY INDUCED DIARRHOEA - THE RECHARGE STUDY, A RANDOMISED PHASE IIB TRIAL. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL.
2013 Keefe, D., Kim, H. -K., Chan, A., Hsieh, R. K., Yu, S. Y., Hernandez, A. B., & Burke, T. (2013). CHEMOTHERAPY INDUCED NAUSEA AND VOMITING (CINV) IN THE ASIA-PACIFIC (AP) REGION - THE AUSTRALIAN PERSPECTIVE FROM THE PAN-AUSTRALASIAN CHEMOTHERAPY INDUCED EMESIS STUDY (PRACTICE). Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL.
2013 Mayo, B., Bateman, E., Stringer, A., Plews, E., Pishas, K., Pietra, C., . . . Keefe, D. (2013). The effect of the new selective GLP-2 agonist, elsiglutide, on irinotecan-induced diarrhoea and mucositis in the rat. Poster session presented at the meeting of Asia-Pacific Journal of Clinical Oncology. Adelaide Convention Centre, Adelaide, South Australia: Wiley Publishing Asia.
DOI
2013 Lacouture, M., Grunberg, S., Keefe, D., Sonis, S., Ely, J., Gernhardt, D., . . . Jatoi, A. (2013). Impact of doxycycline (doxy) prophylaxis on dermatologic toxicity from dacomitinib (D) for NSCLC, by CTCAE and patient (pt)-reported outcomes (PRO) measures in a placebo-controlled trial. Poster session presented at the meeting of EUROPEAN JOURNAL OF CANCER. Amsterdam, NETHERLANDS: ELSEVIER SCI LTD.
2013 Radzuan, M., Bateman, E., Bowen, J., Keefe, D., & Stringer, A. (2013). Intestinal Lactobacillus spp. increase following radiotherapy in rats: an unusual finding. Poster session presented at the meeting of Supportive Care in Cancer. Berlin, Germany: Springer Verlag (Germany).
2013 Bateman, E., Wilson, C., Keefe, C., Bowen, J., Wignall, A., Plews, E., & Keefe, D. (2013). Fractionated radiotherapy in a rat model causes dose-dependent changes in collagen deposition, and expression of transforming growth factor β1, Smad3 and smooth muscle actin α1. Poster session presented at the meeting of Supportive Care in Cancer. Berlin, Germany: Springer Verlag (Germany).
DOI
2013 Mayo, B., Bateman, E., Stringer, A., Plews, E., Pishas, K., Pietra, C., . . . Keefe, D. (2013). The effect of the new selective GLP-2 agonist, Elsiglutide, on irinotecan-induced diarrhoea and mucositis in the rat.. Poster session presented at the meeting of Supportive Care in Cancer. Berlin, Germany: Springer Verlag (Germany).
DOI
2013 Wan Mohamad Zain, W., Bowen, J., Bateman, E., & Keefe, D. (2013). Development of a walker 256-TC tumour-bearing rat model to study lapatinib-induced mucosal injury. Poster session presented at the meeting of Supportive Care in Cancer. Berlin, Germany: Springer Verlag (Germany).
DOI
2012 Keefe, D. (2012). GASTROINTESTINAL TOXICITY IN ONCOLOGY: EVOLUTIONARY SCIENCE. Poster session presented at the meeting of ANNALS OF ONCOLOGY. Vienna, AUSTRIA: OXFORD UNIV PRESS.
WoS1
2011 Bateman, E., Bowen, J., Mayo, B., Plews, E., Darby, J., Stringer, A., . . . Keefe, D. (2011). Further characterisation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor-induced diarrhoea. Poster session presented at the meeting of Abstracts of the 2011 International MASCC/ISOO Symposium, as published in Supportive Care in Cancer. Athens: Springer-Verlag.
DOI
2009 Stringer, A. M., Gibson, R. J., Bowen, J. M., Logan, R. M., Al-Dasooqi, N., & Keefe, D. M. K. (2009). Chemotherapy-induced diarrhoea is associated with a modified microbiome in cancer patients. Poster session presented at the meeting of Abstracts of the Australia & New Zealand Medical & Surgical Gastrointestinal Week 2009, as published in Journal of Gastroenterology and Hepatology. Sydney, N.S.W.: Wiley-Blackwell.
DOI
2000 Olver, I., Vadas, M., Lopez, A., Keefe, D., Taylor, A., Brown, M., & To, L. (2000). A phase 1 study of the GM-CSF antagonist E21R. Poster session presented at the meeting of Proceedings of ASCO - Volume 19 2000. USA: American Society of Clinical Oncology.
DOI
2000 Gibson, R., Keefe, D., Clarke, J., Regester, G., Edwards, B., Thompson, F., . . . Cummins, A. (2000). Interleukin-11 (IL-11) reduces, but not completely ameliorates, intestinal mucositis following chemotherapy in the rat with breast cancer. Poster session presented at the meeting of Abstracts for Australian Gastroenterology Week 2000. Victoria, Australia: Blackwell Science Asia.

Year Citation
2013 Al-Azri, A. S. (2013). The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model. (PhD Thesis, The University of Adelaide).
2008 Logan, R. M. (2008). Alimentary tract mucositis: NF-kB and pro-inflammatory cytokines in the tissues and serum following chemotherapy. (PhD Thesis).
Date Project/ No. Investigators Funding Body Amount
2014

Role of Inflammatory Signalling on Burden of Illness in Mucositis.

 Keefe D, Gibson R, Bowen J & Coller J TRIAD $12,000
2014

Prevention of dacomitinib induced diarrhoea by targeting chloride secretion.

 Bowen J & Keefe D. Pfizer $80,000
2014

South Australian Health and Medical Research Institute – SAHMRI. Innovative Cancer Imaging and Therapeutics Facility.

 C Mulligan, T Hughes, A Zannettino, S Gronthos, D White, D Keefe, T Mondo, D Roder, W Tilley, T Price and P MacKenzie ACRF $1.8M
2014

Cancer Data and Aboriginal Disparities – CANDAD. Development and testing of an integrated cancer monitoring and surveillance system for Aboriginal People in South Australia.

 A Brown, D, Rodda, M Cargo, D Keefe, M Eckert, G Farshid NHMRC $1,034,270
2013

Studies on the effect of Enteragam on gastrointestinal mucositis.

 D Keefe & E Bateman. Entera Health $100,000
2013

Protecting tissues from chemotherapy.

 Callen D, Keefe D, Neilsen P, Smid S NHMRC $565,847
2012

Study into effect of Elsiglutide on gastrointestinal mucositis

  Keefe, Bowen, Stringer and Bateman Helsinn Healthcare $130,000
2012

Identification Of Biomarkers Of Response And Toxicity To Chemoradiotherapy For Oesophageal Tumours

 D Watson, D Keefe, D Hussey and J Bowen NHMRC $481,175
2012

A Nanostructured Drug Delivery Approach for Improved Colorectal Cancer Therapy.

 C Prestidge, B Boyd & D Keefe NHMRC  $541,010
2012

Cyclotherapy: a promising new approach to prevent the side effects of chemotherapy.

 P M Neilsen & D M K Keefe RAH Research Committee $35,000
2010

Improving colorectal cancer therapy using a novel nanotechnology-based delivery system.

 C Prestidge, B Boyd, MP Brown, D Keefe, A Davey Cancer Council SA $110,000
2010

Oral Mucositis Risk and Multicyle Chemotherapy: do multiple cycles multiply risk

 L Elting, S Sonis and D Keefe NIDCR $150,000
2010

CCRE in Oral Health, University of Adelaide

 M Bartold, J Spencer, G Townsend, K Roberts-Thompson & D Keefe NHMRC $2.5m
2009

Studies of Nutritional Supplements as prevention/treatment for gastrointestinal toxicity of chemotherapy

    Nestec $250,000
2008

Investigation of probiotic VSL #3 in DA rat model of mucosal injury.

   VSL Pharma $100,000
2009

Faecal microflora and circulating pro-inflammatory cytokines: key elements to chemotherapy- induced diarrhoea.

 R Gibson, J Bowen, A Stringer, R Logan and D Keefe. Cancer Australia $75, 000
2008

Characterisation of Tyrosine Kinase inhibitor-induced gastrointestinal toxicity

 D Keefe & F Boyle GSK $620, 000
2008

Distiller image analysis software and server

 Tilley, Owens, Norman, Findlay, Keefe NHMRC equipment grant $52,000
2007

Automated image analysis system for the high throughput immuno-histochemical analysis of clinical and experimental samples.

 Tilley, Owens, Norman, Findlay, Keefe & al NHMRC equipment grant $100,695.83
2007

Triad Mucositis Burden of Illness Study: Chronic mucosal injury study

 Elting, Keefe & Sonis Amgen Inc. USD $900,000
2006

Triad Mucositis Burden of Illness Study: Acute mucosal injury cohort expansion

 Elting, Keefe & Sonis Amgen Inc. USD $609,000
2006

Chemotherapy-induced diarrhoea: Characterisation of mechanism

 D Keefe The Cancer Council South Australia $70,500
2006

Oral mucositis: clinical presentation, histological features and pro-inflammatory cytokine expression

 R Logan, R Gibson, D Keefe & S Sonis Australian Dental Research Foundation Inc. (ADRF) $3000
2005

Assessment of an oral supplement in adult cancer patients with mucositis.

 R Butler, P Bardy, T Price, J Davidson, D Keefe & J Webster Biotechnology Innovation Fund (BIF) Grant $490,000
2005

Triad Mucositis Burden of Illness Study

 Elting, Keefe & Sonis Amgen Inc. USD $3,600,000
2005

Triad Mucositis Burden of Illness Study: project scoping study

 Elting, Keefe & Sonis Amgen Inc. US$ 100,000
2005

Investigation of Probiotic effect on mucositis in the DA rat

 D Keefe: Joint venture with Professor Claudio de Simone VSL $30,000
2004

Studies to investigate CG53135 for mucositis treatment in the DA rat mammary adenocarcinoma (DAMA) model

 D Keefe Curagen USD$300, 000
2004

Oral Mucositis in humans

 D Keefe RAH Research Fund $15,000
2003

Studies of KGF/CPT-11 in the DAMA mucositis model

 D Keefe RAHCC Internal funding $60,000
2001

Keratinocyte growth factor research in mucositis

 D Keefe mgen Inc. $50,000
2001

Further studies in mucositis in rats and humans undergoing cytotoxic chemotherapy f or cancer

  D Keefe Anti-cancer Foundation $54,425
2000

Development of the DAMA model

 D Keefe RAHCC Internal Funding $60,000
1999

Mucositis in the rat with breast cancer.

 D Keefe The Queen Elizabeth Hospital (TQEH) Research Foundation $10,000
1999

Investigation and prevention of intestinal mucositis after chemotherapy in the rat with breast cancer

 D Keefe Anti Cancer Foundation $52,000
1997

Mucositis research

  D Keefe & A Cummins B3 funding University of Adelaide $5,000
1997

Mucositis Research

 D Keefe & A Cummins TQEH Research Foundation $5,400
1995

The effect of cancer and chemotherapy on nutrition, and on inducing malabsorption by an immunological mediated enteropathy

 D Keefe & A Cummins. Anti-Cancer Foundation $52,000

 Teaching and Training Innovations and Materials Developed

Date Course Details
2011-2017

Chair, Board of Examiners Years 4 and 5, MBBS Curriculum, University of Adelaide
2006

Initiated and chaired the inaugural meeting of the Chairs of Australian Medical School Curriculum Committees
2005

Developed and conducted the inaugural "Exam Setting Workshop" for the Year 5 final barrier exam for the new medical school curriculum.
2004-2005

Inaugural Co-ordinating Examiner for the Year 5 final barrier exam
2003-2005

Chair of Common Program subcommittee of the MBBS Curriculum Committee.

Developed common program for new medical school curriculum

Curriculum Development 

Date Course Details
2004-2005

Member Assessment Committee, MBBS Curriculum
2004-2005

Member of Year 6 Committee
2003-2005

Member of Year 4/5 Committee
2002-2005

Member MBBS Curriculum Committee during development of new curriculum
1999

Member of Oncology Concept Mapping Group for development of Curriculum 2000

 Curriculum Review

Date Course Details
2006

Submission to the University of Adelaide review of the MBBS program on behalf of the curriculum committee
2006

Member of working group developing submission to the Australian Medical Council regarding accreditation of the University of Adelaide MBBS program. Accreditation achieved until 2011.
2005

Royal Adelaide Hospital Physicians’ Committee Curriculum Workshop. Developed and facilitated a review of medical student selection and assessment, as well as course structure, and generated a report for the University of Adelaide

Post Graduate Medical Training

Date Course Details
2006-2014

RACP State representative for assessment of overseas training in Medical Oncology
2006/2011

Re-accredited supervisor for Medical Oncology Trainees of the Royal Australasian College of Physicians
1996-2007

Long-case FRACP trial examiner, Basic Physician Trainees, RAH
1999-2006

Intern Term Supervisor, Medical Oncology

 Communication Skills Training

Date Course Title
2006

NBCC Train the Trainers workshop

Training future facilitators for communications workshops in cancer
2006

Medical Oncology Group of Australia, Trainee Communications Workshop Training Medical Oncology and Palliative Care Advanced Trainees in communication skills, and mentoring newly trained facilitators
2005

American Society for Clinical Oncology/Clinical Oncological Society of Australia (ASCO/COSA) communication skills workshop: Facilitator

Assessment 

Date Course Title
2008-2017

Chair, MBBS, Year 4/5 Board of Examiners
2007

Member of Academic Progress Review Committee Faculty of Health Sciences
2002-2006

OSCE Examiner for Medical School
2000-2010

Local Examiner for Royal Australasian College of Physicians

Date Role Research Topic Program Degree Type Student Load Student Name
2014 - 2018 Co-Supervisor Intestinal Microvascular Changes and Matrix Metalloproteinases in Radiotherapy-Induced Gastrointestinal Toxicity Doctor of Philosophy Doctorate Full Time Romany Laura Stansborough
2011 - 2012 Co-Supervisor The Safe Administration of Rapid Rituximab Infusion: An Evidence-Based Approach Doctor of Philosophy Doctorate Full Time Miss Siew Ping Lang
2011 - 2016 Principal Supervisor In vitro and in vivo Models to assess the mechanism of Lapatinib - Induced Diarrhoea Doctor of Philosophy Doctorate Full Time Mrs Wan Nor I'zzah Wan Mohamad Zain
2009 - 2013 Co-Supervisor The Role of Matrix Metalloproteinases and their Inhibitors in Irinotecan-Induced Oral Mucositis: An Animal Model Doctor of Clinical Dentistry Doctorate Full Time APrf Abdul Rahman Al 'Azri
2009 - 2014 Co-Supervisor Optimising follow-up for women after primary treatment for early breast cancer Doctor of Philosophy Doctorate Part Time Dr Taryn Bessen
2009 - 2013 Co-Supervisor Assessment of oral mucositis, oral health outcomes, and implementation of a standardized oral health care protocol for a pediatric inpatient population receiving cancer treatment. Doctor of Clinical Dentistry Doctorate Full Time Dr Akram Fareed Qutob
2008 - 2008 Other Exploring the Collective Utility of Population-Based & Clinical Cancer Registries in Assessing Epidemiological, Treatment & Outcome Characteristics of Cancer in South Australia Doctor of Medicine Doctorate Full Time Dr Colin Glen Luke
2008 - 2012 Co-Supervisor Chemotherapy-Induced Mucositis: The Role of Matrix Metalloproteinases and the Extracellular Matrix Doctor of Philosophy Doctorate Full Time Miss Noor Al-Dasooqi
2006 - 2009 Principal Supervisor Chemotherapy-Induced Mucositis: The Role of Gastrointestinal Microflora and Mucins in the Luminal Environment Doctor of Philosophy Doctorate Full Time Dr Andrea Marie Stringer
2004 - 2008 Principal Supervisor Alimentary Tract Mucositis: NF-KB and Pro-Inflammatory Cytokines in the Tissues and Serum Following Chemotherapy Doctor of Philosophy Doctorate Part Time Prof Richard Logan
2002 - 2004 Principal Supervisor Chemotherapy-induced mucositis: Mechanisms of damage, time course of events and possible preventative strategies. Doctor of Philosophy Doctorate Full Time Prof Rachel Gibson
2002 - 2006 Co-Supervisor Chemotherapy-Induced Intestinal Mucositis: The Role of Apoptosis Regulators Doctor of Philosophy Doctorate Full Time Prof Joanne Bowen

Date Role Board name Institution name Country
2014 - ongoing Board Member Breast Cancer Network Australia - Australia

Date Role Committee Institution Country
2014 - ongoing Member Inaugural Palliative Oncology Meeting ASCO United States
2014 - ongoing Member Annual Scientific Meeting ESMO Spain
2014 - ongoing Member Annual Scientific Meeting MASCC United States
2013 - ongoing Member Annual Scientific Meeting MASCC Germany
2013 - ongoing Member SA Comprehensive Cancer Consortium Steering Committee SAHMRI Australia
2013 - 2014 President The Multinational Association for Supportive Care in Cancer - -
2012 - ongoing Member Beat Cancer Project Research Leadership Group SAHMRI Australia
2012 - ongoing Member Clinical Research and Drug and Device Development Pillar Committee SAHMRI Australia
2012 - ongoing Member Annual Scientific Meeting ESMO Austria
2011 - ongoing Member Annual Scientific Meeting MASCC Greece
2010 - ongoing Member Annual Scientific Meeting European Society for Medical Oncology Italy
2010 - ongoing Member Annual Scientific Meeting Multinational Association of Supportive Care in Cancer Canada
2010 - 2012 President The Multinational Association for Supportive Care in Cancer - -
2010 - ongoing Member Scientific Advisory Group SA Cancer Research Collaborative Australia
2009 - 2013 Member South Australian Clinical Senate - Australia
2009 - 2011 Member Cancer Research Advisory Committee The Cancer Council South Australia Australia
2009 - ongoing Member Annual Scientific Meeting Multinational Association of Supportive Care in Cancer Italy
2008 - 2010 Vice-President The Multinational Association of Supportive Care in Cancer) - -
2007 - 2010 Chair Optimising Cancer Care Subcommittee Cancer Clinical Network -
2006 - 2010 Chair Governance Subcommittee MASCC -
2006 - 2008 Member Communication Steering Committee National Breast Cancer Centre Australia
2006 - 2008 Member Cancer Council Helpline Advisory Panel Cancer Council South Australia Australia
2006 - ongoing Member Annual Scientific Meeting Multinational Association of Supportive Care in Cancer/ International Society of Ocular Oncology Canada
2005 - ongoing Member Annual Scientific Meeting The Multinational Association of Supportive Care in Cancer/ International Society of Ocular Oncology Switzerland
2005 - 2006 Member Member Workforce Subcommittee Statewide Cancer Control Plan Australia
2004 - 2008 Member Board of Directors MASCC Australia
2004 - 2008 Chair Mucositis Study Group MASCC Australia
2004 - ongoing Member The Multinational Association of Supportive Care in Cancer/ International Society of Ocular Oncology The Multinational Association of Supportive Care in Cancer/ International Society of Ocular Oncology United States
2003 - 2011 Member Board of Directors The Cancer Council South Australia Australia
2003 - 2006 Member National Grants Steering Committee The Cancer Council Australia Australia
2003 - 2006 Member Peter Nelson Leukemia Research Fellowship Committee - -
2003 - 2006 Chair Cancer Research Advisory Committee The Cancer Council South Australia Australia
2002 - 2006 Member Education Subcommittee Medical Oncology Group of Australia Australia
1999 - 2001 Member Cancer Research Advisory Committee The Cancer Council South Australia Australia

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