| 2025 |
Kan, W. L., Weekley, C. M., Nero, T. L., Hercus, T. R., Yip, K. H., Tumes, D. J., . . . Parker, M. W. (2025). The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities. Immunological Reviews, 329(1), e13430-1-e13430-25. DOI Scopus2 WoS4 Europe PMC1 |
| 2025 |
Ryan, F. J., Clarke, M., Lynn, M. A., Benson, S. C., McAlister, S., Giles, L. C., . . . Lynn, D. J. (2025). Bifidobacteria support optimal infant vaccine responses. Nature, 641(8062), 456-464. DOI Scopus21 WoS20 Europe PMC16 |
| 2025 |
Tedesco, L., Ali, S. B., Erman, B., Baris, S., Pant, H., Hissaria, P., . . . Cildir, G. (2025). IgG4-Related Disease: Emerging Roles of Novel Genetic Variants, Immune Cell Subsets and Therapeutic Targets. Allergy. European Journal of Allergy and Clinical Immunology, 80(10), 2738-2754. DOI Scopus1 WoS1 |
| 2025 |
Yagyu, H., Kiuchi, M., Sasaki, A., Itakura, E., Kokubo, K., Iwamura, C., . . . Hirahara, K. (2025). Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity. Science Immunology, 10(112), 18 pages. DOI Scopus1 WoS1 |
| 2025 |
Kiuchi, M., Nemoto, M., Yagyu, H., Aoki, A., Iwamura, C., Sugimoto, H., . . . Hirahara, K. (2025). Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells. Science, 390(6778), eadp0714. DOI |
| 2025 |
Wang, H., Tumes, D. J., Keam, S., Lim, J. W., Nguyen, Q. A., Vlahos, R., . . . Yip, K. H. (2025). βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism. Frontiers in Immunology, 16, 16 pages. DOI |
| 2024 |
Wang, H., Yip, K. H., Keam, S. P., Vlahos, R., Nichol, K., Wark, P., . . . Tumes, D. J. (2024). Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade. Journal of Allergy and Clinical Immunology, 153(3), 672-683.e6. DOI Scopus9 WoS9 Europe PMC8 |
| 2024 |
Aba, Ü., Maslak, İ. C., İpşir, C., Pehlivan, D., Warnock, N. I., Tumes, D. J., . . . Erman, B. (2024). A novel homozygous germline mutation in transferrin receptor 1 (TfR1) leads to combined immunodeficiency and provides new insights into iron-immunity axis. Journal of Clinical Immunology, 44(2, article no. 55), 1-14. DOI Scopus9 WoS9 Europe PMC7 |
| 2024 |
Wallach, I., Bernard, D., Nguyen, K., Ho, G., Tumes, D., Cildir, G., & Heifets, A. (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14(1), 1-16. DOI Scopus66 WoS73 Europe PMC68 |
| 2024 |
Cildir, G., Aba, U., Pehlivan, D., Tvorogov, D., Warnock, N. I., Ipsir, C., . . . Erman, B. (2024). Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans. Nature Communications, 15(1), 9944-1-9944-18. DOI Scopus1 WoS1 Europe PMC1 |
| 2023 |
Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2023). Correction to: Do more with Less: Improving High Parameter Cytometry Through Overnight Staining (Current Protocols, (2022), 2, 11, 10.1002/cpz1.589). Current Protocols, 3(1), e678. DOI Scopus1 WoS1 Europe PMC1 |
| 2023 |
Yip, K. H., Chao, J., Coolen, C., Pant, H., Kral, A., Smith, W., . . . Tumes, D. J. (2023). IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ. Journal of Allergy and Clinical Immunology, 152(3), 725-735. DOI Scopus5 WoS5 Europe PMC3 |
| 2022 |
Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2022). Do more with less: improving high parameter cytometry through overnight staining. Current Protocols, 2(11, article no. e589), 1-20. DOI Scopus37 WoS34 Europe PMC34 |
| 2022 |
Stevens, N. E., van Wolfswinkel, M., Bao, W., Ryan, F. J., Brook, B., Amenyogbe, N., . . . Lynn, D. J. (2022). Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice. Vaccine, 40(11), 1594-1605. DOI Scopus10 WoS10 Europe PMC8 |
| 2022 |
Yip, K. H., McKenzie, D., Ramshaw, H. S., Chao, J., McClure, B. J., Raquet, E., . . . Tumes, D. J. (2022). Targeting the human βc Receptor inhibits contact dermatitis in a transgenic mouse model. The Journal of Investigative Dermatology, 142(4), 1103-1113. DOI Scopus7 WoS7 Europe PMC7 |
| 2022 |
Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., . . . Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death and Disease, 13(137), 1-11. DOI Scopus29 WoS27 Europe PMC20 |
| 2022 |
Pant, H., Hercus, T. R., Tumes, D. J., Yip, K. H., Parker, M. W., Owczarek, C. M., . . . Huston, D. P. (2022). Translating the biology of β common receptor-engaging cytokines into clinical medicine. Journal of Allergy and Clinical Immunology, 151(2), 324-344. DOI Scopus15 WoS11 Europe PMC11 |
| 2021 |
Nakajima, T., Kanno, T., Yokoyama, S., Sasamoto, S., Asou, H. K., Tumes, D. J., . . . Endo, Y. (2021). ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. Journal of Experimental Medicine, 218(12, article no. e20210639), 1-27. DOI Scopus29 WoS30 Europe PMC28 |
| 2021 |
Cildir, G., & Tumes, D. J. (2021). DOT1L leaves its mark on adaptive immunity. Immunology and Cell Biology, 99(4), 348-350. DOI Scopus1 WoS1 |
| 2021 |
Blake, S. J., James, J., Ryan, F. J., Caparros-Martin, J., Eden, G. L., Tee, Y. C., . . . Lynn, D. J. (2021). The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota. Cell Reports Medicine, 2(12), 100464-1-100464-e9. DOI Scopus29 WoS29 Europe PMC30 |
| 2021 |
Cildir, G., Yip, K. H., Pant, H., Tergaonkar, V., Lopez, A. F., & Tumes, D. J. (2021). Understanding mast cell heterogeneity at single cell resolution. Trends in Immunology, 42(6), 523-535. DOI Scopus32 WoS29 Europe PMC29 |
| 2021 |
De Silva, A. P., Schembri, M. A., Sarah, A. H., Chao, J., Yip, K. H., Cildir, G., . . . Pant, H. (2021). Short-term oral steroids significantly improves chronic rhinosinusitis without nasal polyps. Laryngoscope, 131(10), E2618-E2626. DOI Scopus6 WoS6 Europe PMC4 |
| 2021 |
Zadeh Shirazi, A., McDonnell, M. D., Fornaciari, E., Bagherian, N. S., Scheer, K. G., Samuel, M. S., . . . Gomez, G. A. (2021). A deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma. British Journal of Cancer, 125(3), 337-350. DOI Scopus32 WoS24 Europe PMC29 |
| 2020 |
Yip, K. H., Wilson, N. J., Pant, H., Brown, C. L., Busfield, S., Ng, M., . . . Owczarek, C. M. (2020). Anti-βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model. Allergy, 75(2), 475-478. DOI Scopus10 WoS9 Europe PMC8 |
| 2020 |
Hojyo, S., Tumes, D., Murata, A., & Tokoyoda, K. (2020). Multiple developmental pathways lead to the generation of CD4 T-cell memory. International Immunology, 32(9), 589-595. DOI Scopus9 WoS9 Europe PMC8 |
| 2020 |
Suzuki, A. S., Yagi, R., Kimura, M. Y., Iwamura, C., Shinoda, K., Onodera, A., . . . Nakayama, T. (2020). Essential role for CD30-transglutaminase 2 axis in memory Th1 and Th17 cell generation. Frontiers in Immunology, 11(1536), 1-12. DOI Scopus7 WoS7 Europe PMC10 |
| 2020 |
Sarkander, J., Hojyo, S., Mursell, M., Yamasaki, Y., Wu, T. Y., Tumes, D. J., . . . Tokoyoda, K. (2020). Enhanced cell division is required for the generation of memory CD4 T cells to migrate into their proper location. Frontiers in Immunology, 10(3113), 1-12. DOI Scopus3 WoS3 Europe PMC3 |
| 2019 |
Ichikawa, T., Hirahara, K., Kokubo, K., Kiuchi, M., Aoki, A., Morimoto, Y., . . . Nakayama, T. (2019). CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells. Nature Immunology, 20(11), 1469-1480. DOI Scopus111 WoS105 Europe PMC99 |
| 2019 |
Endo, Y., Onodera, A., Obata Ninomiya, K., Koyama Nasu, R., Asou, H. K., Ito, T., . . . Nakayama, T. (2019). ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis. Nature metabolism, 1(2), 261-275. DOI Scopus66 WoS70 Europe PMC62 |
| 2019 |
Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., . . . Nakayama, T. (2019). Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology. Journal of allergy and clinical immunology, 144(2), 549-560.e 10. DOI Scopus30 WoS27 Europe PMC25 |
| 2019 |
Yip, K. H., Papadopoulos, M., Pant, H., & Tumes, D. J. (2019). The role of invariant T cells in inflammation of the skin and airways. Seminars in Immunopathology, 41(3), 401-410. DOI Scopus19 WoS18 Europe PMC18 |
| 2018 |
Lynn, M., Tumes, D., Choo, J., Sribnaia, A., Blake, S., Leong, L., . . . Lynn, D. (2018). Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice. Cell Host and Microbe, 23(5), 653-660. DOI Scopus166 WoS152 Europe PMC144 |
| 2018 |
Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., . . . Nakayama, T. (2018). DUSP10 constrains innate IL-33-mediated cytokine production in ST2ʰᶦ memory-type pathogenic Th2 cells. Nature communications, 9(1, article no. 4231), 1-15. DOI Scopus40 WoS41 Europe PMC35 |
| 2017 |
Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., & Nakayama, T. (2017). Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma. Immunological reviews, 278(1), 8-19. DOI Scopus83 WoS76 Europe PMC67 |
| 2017 |
Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., . . . Okamoto, Y. (2017). Th2 cells in health and disease. Annual review of immunology, 35(1), 53-84. DOI Scopus336 WoS300 Europe PMC283 |
| 2016 |
Angela, M., Endo, Y., Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., . . . Nakayama, T. (2016). Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. Nature communications, 7(13683), 1-15. DOI Scopus215 WoS204 Europe PMC204 |
| 2016 |
Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., . . . Nakayama, T. (2016). Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Science immunology, 1(3, article no. eaaf9154), 10 pages. DOI Scopus59 WoS58 Europe PMC50 |
| 2016 |
Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., . . . Nakayama, T. (2016). Thy1+ IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proceedings of the National Academy of Sciences of the United States of America, 113(20), E2842-E2851. DOI Scopus115 WoS101 Europe PMC100 |
| 2015 |
Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., . . . Nakayama, T. (2015). The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity, 42(2), 294-308. DOI Scopus213 WoS188 Europe PMC174 |
| 2015 |
Onodera, A., Tumes, D. J., Watanabe, Y., Hirahara, K., Kaneda, A., Sugiyama, F., . . . Nakayama, T. (2015). Spatial interplay between polycomb and trithorax complexes controls transcriptional activity in T lymphocytes. Molecular and cellular biology, 35(22), 3841-3853. DOI Scopus17 WoS16 Europe PMC13 |
| 2015 |
Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., . . . Nakayama, T. (2015). Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell reports, 12(6), 1042-1055. DOI Scopus221 WoS213 Europe PMC203 |
| 2015 |
Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., . . . Nakayama, T. (2015). Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells. Journal of biological chemistry, 290(21), 13095-13103. DOI Scopus29 WoS28 Europe PMC26 |
| 2014 |
Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata Ninomiya, K., Wada, T., . . . Nakayama, T. (2014). Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proceedings of the National Academy of Sciences of the United States of America, 111(35), 12829-12834. DOI Scopus17 WoS13 Europe PMC14 |
| 2014 |
Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., & Nakayama, T. (2014). Pathogenic memory type Th2 cells in allergic inflammation. Trends in immunology, 35(2), 69-78. DOI Scopus110 WoS102 Europe PMC97 |
| 2013 |
Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., . . . Nakayama, T. (2013). The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells. Immunity, 39(5), 819-832. DOI Scopus262 WoS249 Europe PMC240 |
| 2013 |
Onodera, A., Tumes, D. J., & Nakayama, T. (2013). Too much of a good thing. Nature Immunology, 14(2), 112-114. DOI Scopus1 WoS1 Europe PMC1 |
| 2013 |
Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., . . . Nakayama, T. (2013). Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4691-4696. DOI Scopus72 WoS67 Europe PMC66 |
| 2012 |
Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., . . . Nakayama, T. (2012). Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proceedings of the National Academy of Sciences of the United States of America, 109(42), 16992-16997. DOI Scopus24 WoS26 Europe PMC22 |
| 2012 |
Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., . . . Nakayama, T. (2012). Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leukemia and lymphoma, 53(3), 479-486. DOI Scopus3 WoS4 Europe PMC4 |
| 2012 |
Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., . . . Nakayama, T. (2012). Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proceedings of the National Academy of Sciences of the United States of America, 109(19), 7409-7414. DOI Scopus113 WoS111 Europe PMC110 |
| 2012 |
Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., . . . Nakayama, T. (2012). The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nature immunology, 13(8), 778-786. DOI Scopus155 WoS146 Europe PMC149 |
| 2011 |
Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., . . . Nakayama, T. (2011). Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity, 35(5), 733-745. DOI Scopus101 WoS95 Europe PMC87 |
| 2011 |
Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., . . . Nakayama, T. (2011). Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells. Cancer Research, 71(14), 4790-4798. DOI Scopus28 WoS24 Europe PMC24 |
| 2010 |
Suzuki, A., Iwamura, C., Shinoda, K., Tumes, D. J., Kimura, M. Y., Hosokawa, H., . . . Nakayama, T. (2010). Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. Journal of immunology, 184(8), 4510-4520. DOI Scopus20 WoS18 Europe PMC15 |
| 2009 |
Tumes, D., Connolly, A., & Dent, L. (2009). Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. International Immunology, 21(6), 633-644. DOI Scopus21 WoS17 Europe PMC16 |
| 2008 |
Tumes, D., Wong, A., Sewell, W., McColl, S., Connolly, A., & Dent, L. (2008). Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice. Molecular Immunology, 45(13), 3609-3617. DOI Scopus8 WoS8 Europe PMC6 |
| 2008 |
Giacomin, P., Cava, M., Tumes, D., Gauld, A., Iddawela, D., McColl, S., . . . Dent, L. (2008). Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis. Parasite Immunology, 30(8), 435-445. DOI Scopus13 WoS10 Europe PMC9 |
| 2007 |
Tumes, D., Cormie, J., Calvert, M., Stewart, K., Nassenstein, C., Braun, A., . . . Dent, L. (2007). Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils. Journal of Leukocyte Biology, 81(6), 1362-1373. DOI Scopus37 WoS36 Europe PMC30 |
| 2006 |
Nassenstein, C., Kutschker, J., Tumest, D., & Braun, A. (2006). Neuro-immune interaction in allergic asthma: Role of neurotrophins. Biochemical Society Transactions, 34(4), 591-593. DOI Scopus33 WoS27 Europe PMC27 |