Damon Tumes
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Research themes and projects in the Allergy and Cancer Immunology Laboratory (Tumes Lab):
Epigenetic regulation of Th2 cells in chronic allergic inflammation
Almost every cell in an individual has identical DNA yet can differentiate into all of the specialized cells of the body. This is accomplished via epigenetic regulation of gene expression. Our laboratory investigates how allergy associated T cells called Th2 cells are epigenetically programmed to drive diseases including asthma and chronic rhinosinusitis. Gata3 is a key driver of Th2 cell differentiation, and we have defined an intronic enhancer region of the Gata3 gene that is very important for epigenetic programming of Th2 cells. This project will extend these findings to determine how epigenetic regulation of Gata3 occurs in CD4 T cells using in vitro models of Th2 cell differentiation, 3D analysis of chromatin conformation, and newly developed in vivo asthma models.
Defining inflammatory networks and granulocyte heterogeneity in severe asthma
Severe asthma affects one in six asthmatics, yet this cohort comprises more than half of the $28 b/year asthma cost to Australia as these patients have a higher risk of life-threatening asthma attacks, poorer quality of life and progressive non-reversible loss of airway function. This project will 1) use spatial transcriptomics and computational analysis of cell-cell signalling networks to define inflammatory networks underlying severe steroid resistant airway inflammation and 2) use single cell RNA-Sequencing and proteomics to define new granulocyte subsets in the airways of humans with asthma. Until recently, eosinophils were viewed as homogenous effector cells that attack parasitic worms and viruses and often underlie chronic asthma. We have defined several new subsets of eosinophils in the airways of patients with chronic rhinosinusitis and asthma and this project will determine their functions and the potential to target them to treat severe airway disease.
Hijacking allergic inflammation to treat cancer
Groundbreaking discoveries in immunotherapy, such as inhibition of checkpoint receptors on T cells and chimeric antigen receptor (CAR) T cells have provided new hope in the war against cancer. Allergic inflammation manifests as strong aberrant responses to antigens in the environment; however, how these pathways intersect with cancer remains poorly understood. We have shown that polarisation of CD4 T cells to produce allergy driving cytokines results in enhanced ability to kill established lymphomas. This exciting finding shows that it may be possible to harness the strong pathophysiological mechanisms that normally drive allergic inflammation to treat cancer. This project will define how we can enhance T cell function in cancer and how the effector granulocytes (e.g. eosinophils, mast cells and basophils) that normally drive allergy can be manipulated to abolish solid tumors.
Deciphering epithelial programming events that potentiate development of asthma
Respiratory infections in early life are strongly associated with asthma development yet the mechanisms are unknown. This project uses in vitro 3D tissue organoid differentiation models and analysis of airway tissue from humans to determine how the airway epithelium is epigenetically programmed during differentiation and during early life.
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Journals
Year Citation 2024 Wang, H., Yip, K. H., Keam, S. P., Vlahos, R., Nichol, K., Wark, P., . . . Tumes, D. J. (2024). Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade. Journal of Allergy and Clinical Immunology, 153(3), 672-683.e6.
Scopus12024 Aba, Ü., Maslak, İ. C., İpşir, C., Pehlivan, D., Warnock, N. I., Tumes, D. J., . . . Erman, B. (2024). A Novel Homozygous Germline Mutation in Transferrin Receptor 1 (TfR1) Leads to Combined Immunodeficiency and Provides New Insights into Iron-Immunity Axis. Journal of Clinical Immunology, 44(2), 14 pages.
Scopus2 Europe PMC12024 Inglis, J. M., Medlin, S., Bryant, K., Mangoni, A. A., & Phillips, C. J. (2024). The Clinical Impact of Hospital-Acquired Adverse Drug Reactions in Older Adults: An Australian Cohort Study. Journal of the American Medical Directors Association, 25(8), 9 pages.
2024 Cildir, G., Aba, U., Pehlivan, D., Tvorogov, D., Warnock, N. I., Ipsir, C., . . . Erman, B. (2024). Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans.. Nature communications, 15(1), 9944.
2024 Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., . . . Taglialatela, A. (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14(1), 16 pages.
Scopus19 Europe PMC122024 Le, T. N., Afshar Ali, M., Gadzhanova, S., Lim, R., Bala, I., Bogale, K. N., & Gillam, M. (2024). Hernia repair prevalence by age and gender among the Australian adult population from 2017 to 2021. Critical Public Health, 34(1), 1-11.
2024 Tatar, A., Haghighi, M., & Zeinijahromi, A. (2024). Experiments on image data augmentation techniques for geological rock type classification with convolutional neural networks. Journal of Rock Mechanics and Geotechnical Engineering.
Scopus12023 Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2023). Correction to: Do more with Less: Improving High Parameter Cytometry Through Overnight Staining (Current Protocols, (2022), 2, 11, 10.1002/cpz1.589). Current Protocols, 3(1), e678.
2023 Yip, K. H., Chao, J., Coolen, C., Pant, H., Kral, A., Smith, W., . . . Tumes, D. J. (2023). IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ. Journal of Allergy and Clinical Immunology, 152(3), 725-735.
Scopus2 WoS1 Europe PMC12022 Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2022). Do more with Less: Improving High Parameter Cytometry Through Overnight Staining. Current Protocols, 2(11), 20 pages.
Scopus13 Europe PMC112022 Stevens, N. E., van Wolfswinkel, M., Bao, W., Ryan, F. J., Brook, B., Amenyogbe, N., . . . Lynn, D. J. (2022). Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice. Vaccine, 40(11), 1594-1605.
Scopus8 WoS3 Europe PMC52022 Yip, K. H., McKenzie, D., Ramshaw, H. S., Chao, J., McClure, B. J., Raquet, E., . . . Tumes, D. J. (2022). Targeting the human βc Receptor inhibits contact dermatitis in a transgenic mouse model. The Journal of Investigative Dermatology, 142(4), 1103-1113.
Scopus3 WoS2 Europe PMC22022 Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., . . . Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death and Disease, 13(2), 11 pages.
Scopus14 WoS5 Europe PMC62022 Pant, H., Hercus, T. R., Tumes, D. J., Yip, K. H., Parker, M. W., Owczarek, C. M., . . . Huston, D. P. (2022). Translating the biology of β common receptor-engaging cytokines into clinical medicine. Journal of Allergy and Clinical Immunology, 151(2), 324-344.
Scopus8 WoS1 Europe PMC22021 Nakajima, T., Kanno, T., Yokoyama, S., Sasamoto, S., Asou, H. K., Tumes, D. J., . . . Endo, Y. (2021). Acc1-expressing pathogenic t helper 2 cell populations facilitate lung and skin inflammation in mice. Journal of Experimental Medicine, 218(12), 27 pages.
Scopus19 WoS9 Europe PMC112021 Cildir, G., & Tumes, D. J. (2021). DOT1L leaves its mark on adaptive immunity. Immunology and Cell Biology, 99(4), 348-350.
2021 Blake, S. J., James, J., Ryan, F. J., Caparros-Martin, J., Eden, G. L., Tee, Y. C., . . . Lynn, D. J. (2021). The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota. Cell Reports Medicine, 2(12), 100464-1-100464-e9.
Scopus20 WoS10 Europe PMC172021 Cildir, G., Yip, K. H., Pant, H., Tergaonkar, V., Lopez, A. F., & Tumes, D. J. (2021). Understanding mast cell heterogeneity at single cell resolution. Trends in Immunology, 42(6), 523-535.
Scopus24 WoS15 Europe PMC172021 De Silva, A. P., Schembri, M. A., Sarah, A. H., Chao, J., Yip, K. H., Cildir, G., . . . Pant, H. (2021). Short-term Oral Steroids Significantly Improves Chronic Rhinosinusitis Without Nasal Polyps. Laryngoscope, 131(10), E2618-E2626.
Scopus5 WoS2 Europe PMC22021 Zadeh Shirazi, A., McDonnell, M. D., Fornaciari, E., Bagherian, N. S., Scheer, K. G., Samuel, M. S., . . . Gomez, G. A. (2021). A deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma. British Journal of Cancer, 125(3), 337-350.
Scopus24 WoS13 Europe PMC162020 Yip, K. H., Wilson, N. J., Pant, H., Brown, C. L., Busfield, S., Ng, M., . . . Owczarek, C. M. (2020). Anti-βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model. Allergy, 75(2), 475-478.
Scopus9 WoS7 Europe PMC32020 Hojyo, S., Tumes, D., Murata, A., & Tokoyoda, K. (2020). Multiple developmental pathways lead to the generation of CD4 T-cell memory. International Immunology, 32(9), 589-595.
Scopus8 WoS6 Europe PMC72020 Suzuki, A. S., Yagi, R., Kimura, M. Y., Iwamura, C., Shinoda, K., Onodera, A., . . . Nakayama, T. (2020). Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation. Frontiers in Immunology, 11, 12 pages.
Scopus4 WoS2 Europe PMC42020 Sarkander, J., Hojyo, S., Mursell, M., Yamasaki, Y., Wu, T. Y., Tumes, D. J., . . . Tokoyoda, K. (2020). Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location. Frontiers in Immunology, 10, 12 pages.
Scopus1 WoS2 Europe PMC12019 Ichikawa, T., Hirahara, K., Kokubo, K., Kiuchi, M., Aoki, A., Morimoto, Y., . . . Nakayama, T. (2019). CD103<sup>hi</sup> T<inf>reg</inf> cells constrain lung fibrosis induced by CD103<sup>lo</sup> tissue-resident pathogenic CD4 T cells. Nature Immunology, 20(11), 1469-1480.
Scopus88 WoS69 Europe PMC562019 Endo, Y., Onodera, A., Obata-Ninomiya, K., Koyama-Nasu, R., Asou, H. K., Ito, T., . . . Nakayama, T. (2019). ACC1 determines memory potential of individual CD4<sup>+</sup> T cells by regulating de novo fatty acid biosynthesis. Nature Metabolism, 1(2), 261-275.
Scopus43 WoS23 Europe PMC292019 Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., . . . Nakayama, T. (2019). Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology. Journal of Allergy and Clinical Immunology, 144(2), 549-560.e10.
Scopus25 WoS17 Europe PMC162019 Yip, K. H., Papadopoulos, M., Pant, H., & Tumes, D. J. (2019). The role of invariant T cells in inflammation of the skin and airways. Seminars in Immunopathology, 41(3), 401-410.
Scopus12 WoS9 Europe PMC102018 Lynn, M., Tumes, D., Choo, J., Sribnaia, A., Blake, S., Leong, L., . . . Lynn, D. (2018). Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice. Cell Host and Microbe, 23(5), 653-660.
Scopus144 WoS111 Europe PMC1092018 Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., . . . Nakayama, T. (2018). DUSP10 constrains innate IL-33-mediated cytokine production in ST2<sup>hi</sup> memory-type pathogenic Th2 cells. Nature Communications, 9(1), 15 pages.
Scopus36 WoS23 Europe PMC262017 Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., & Nakayama, T. (2017). Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma. Immunological Reviews, 278(1), 8-19.
Scopus75 WoS55 Europe PMC432017 Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., . . . Okamoto, Y. (2017). Th2 cells in health and disease. Annual Review of Immunology, 35(1), 53-84.
Scopus286 WoS214 Europe PMC1792016 Angela, M., Endo, Y., Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., . . . Nakayama, T. (2016). Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. Nature Communications, 7(1), 15 pages.
Scopus184 WoS127 Europe PMC1172016 Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., . . . Nakayama, T. (2016). Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Science Immunology, 1(3), 10 pages.
Scopus54 WoS40 Europe PMC382016 Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., . . . Nakayama, T. (2016). Thy1<sup>+</sup> IL-7<sup>+</sup> lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proceedings of the National Academy of Sciences of the United States of America, 113(20), E2842-E2851.
Scopus101 WoS79 Europe PMC722015 Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., . . . Nakayama, T. (2015). The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity, 42(2), 294-308.
Scopus195 WoS146 Europe PMC1242015 Onodera, A., Tumes, D. J., Watanabe, Y., Hirahara, K., Kaneda, A., Sugiyama, F., . . . Nakayama, T. (2015). Spatial interplay between polycomb and trithorax complexes controls transcriptional activity in T lymphocytes. Molecular and Cellular Biology, 35(22), 3841-3853.
Scopus17 WoS14 Europe PMC112015 Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., . . . Nakayama, T. (2015). Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Reports, 12(6), 1042-1055.
Scopus181 WoS126 Europe PMC1242015 Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., . . . Nakayama, T. (2015). Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells. Journal of Biological Chemistry, 290(21), 13095-13103.
Scopus29 WoS23 Europe PMC202014 Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., . . . Nakayama, T. (2014). Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proceedings of the National Academy of Sciences of the United States of America, 111(35), 12829-12834.
Scopus17 WoS12 Europe PMC122014 Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., & Nakayama, T. (2014). Pathogenic memory type Th2 cells in allergic inflammation. Trends in Immunology, 35(2), 69-78.
Scopus108 WoS91 Europe PMC792013 Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., . . . Nakayama, T. (2013). The Polycomb protein Ezh2 regulates differentiation and plasticity of CD4<sup>+</sup> T helper Type 1 and type 2 cells. Immunity, 39(5), 819-832.
Scopus243 WoS192 Europe PMC1802013 Onodera, A., Tumes, D. J., & Nakayama, T. (2013). Too much of a good thing. Nature Immunology, 14(2), 112-114.
Scopus1 WoS1 Europe PMC12013 Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., . . . Nakayama, T. (2013). Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4691-4696.
Scopus68 WoS57 Europe PMC532012 Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., . . . Nakayama, T. (2012). Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proceedings of the National Academy of Sciences of the United States of America, 109(42), 16992-16997.
Scopus23 WoS23 Europe PMC162012 Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., . . . Nakayama, T. (2012). Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leukemia and Lymphoma, 53(3), 479-486.
Scopus3 WoS3 Europe PMC42012 Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., . . . Nakayama, T. (2012). Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proceedings of the National Academy of Sciences of the United States of America, 109(19), 7409-7414.
Scopus100 WoS93 Europe PMC832012 Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., . . . Nakayama, T. (2012). The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T <inf>H</inf>2 differentiation. Nature Immunology, 13(8), 778-786.
Scopus144 WoS116 Europe PMC1152011 Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., . . . Nakayama, T. (2011). Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity, 35(5), 733-745.
Scopus97 WoS85 Europe PMC692011 Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., . . . Nakayama, T. (2011). Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells. Cancer Research, 71(14), 4790-4798.
Scopus25 WoS22 Europe PMC172010 Suzuki, A., Iwamura, C., Shinoda, K., Tumes, D. J., Kimura, M. Y., Hosokawa, H., . . . Nakayama, T. (2010). Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. Journal of Immunology, 184(8), 4510-4520.
Scopus19 WoS16 Europe PMC152009 Tumes, D., Connolly, A., & Dent, L. (2009). Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. International Immunology, 21(6), 633-644.
Scopus20 WoS16 Europe PMC142008 Tumes, D., Wong, A., Sewell, W., McColl, S., Connolly, A., & Dent, L. (2008). Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice. Molecular Immunology, 45(13), 3609-3617.
Scopus8 WoS8 Europe PMC52008 Giacomin, P., Cava, M., Tumes, D., Gauld, A., Iddawela, D., McColl, S., . . . Dent, L. (2008). Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis. Parasite Immunology, 30(8), 435-445.
Scopus12 WoS8 Europe PMC52007 Tumes, D., Cormie, J., Calvert, M., Stewart, K., Nassenstein, C., Braun, A., . . . Dent, L. (2007). Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils. Journal of Leukocyte Biology, 81(6), 1362-1373.
Scopus35 WoS29 Europe PMC222006 Nassenstein, C., Kutschker, J., Tumest, D., & Braun, A. (2006). Neuro-immune interaction in allergic asthma: Role of neurotrophins. Biochemical Society Transactions, 34(4), 591-593.
Scopus33 WoS27 Europe PMC19 -
Conference Papers
Year Citation 2024 Yin, X., Stuart, T., Chen, S. J., Gutruf, P., & Fumeaux, C. (2024). 3D-Printed Wearable Antenna Integrated with Rectifier for Wireless Power Transfer. In 2024 18th European Conference on Antennas and Propagation (EuCAP) (pp. 1-5). IEEE.
DOI2021 Shirazi, A. Z., McDonnell, M. D., Fornaciari, E., Bagherian, N. S., Scheer, K. G., Samuel, M. S., . . . Gomez, G. A. (2021). A deep convolutional neural network for segmentation of whole-slide pathology images in glioblastoma. In CLINICAL CANCER RESEARCH Vol. 27 (pp. 2 pages). AMER ASSOC CANCER RESEARCH.
DOI2016 Tumes, D., Onodera, A., Papadopoulos, M., & Nakayama, T. (2016). Epigenetic control of Gata3 gene expression in T helper 2 cells via histone modification and DNA conformation. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 1213). Melbourne, AUSTRALIA: WILEY-BLACKWELL. 2016 Onodera, A., Tumes, D., Kiuchi, M., Kokubo, K., Watanabe, Y., Hirahara, K., . . . Nakayama, T. (2016). Spatial interplay between Polycomb and trithorax complexes controls transcriptional activity in T lymphocytes. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 336). Melbourne, AUSTRALIA: WILEY-BLACKWELL. 2015 Stuchbery, R., Mangiola, S., Tan, Y., Rupasinghe, T., Dayalan, S., Tull, D., . . . Corcoran, N. (2015). High risk prostate cancer is associated with distinct transcriptional and lipid profiles in adipose tissue. In BJU INTERNATIONAL Vol. 116 (pp. 39-40). AUSTRALIA, Cairns: WILEY-BLACKWELL. 2013 Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., . . . Nakayama, T. (2013). The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells.. In JOURNAL OF IMMUNOLOGY Vol. 190 (pp. 1 page). Honolulu, HI: AMER ASSOC IMMUNOLOGISTS. 2005 Tumes, D., Stewart, K., Calvert, M., Cormie, J., & Dent, L. (2005). Comparative studies of susceptibility to experimental asthma in commonly used mouse strains. In Tissue Antigens Vol. 65 (pp. 570). Melbourne, Australia: Blackwell.
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Preprint
Year Citation 2020 Mangiola, S., Thomas, E., Modrák, M., & Papenfuss, A. (2020). A Bayesian inference tool for identifying artifactual calls from differential transcript abundance analyses.
DOI
MRFF Preventive and Public Health Research Initiative Chronic Respiratory Conditions Grant Proposal – Stream 1 (2024-2028). Role Co-CI. Reducing Steroid and Antibiotic Use in Rhinosinusitis and Asthma with Precision Medicine.
The Hospital Research Foundation project grant (2024-2025). Role Co-CI. Investigating the role of a novel genetic loci underlying urticaria development.
NHMRC Ideas Grant APP (2024-2027). Role AI. Elucidating the function of a novel regulator of IgE-mediated mast cell activation and chronic spontaneous urticaria development.
Channel 7 Children’s Research Foundation (2022-2024). Role CIA. Does airway epithelial progenitor cell reprogramming by viral and bacterial infections cause childhood asthma?
The Hospital Research Foundation project grant (2022-2024). Role CIA. Creating a diagnostic tool to identify antigens causing IgE-and non-IgE-mediated inflammation in people with eczema.
The Hospital Research Foundation project grant (2022-2024). Role CIA. Mapping inflammatory networks in asthmatics for personalised therapy.
NHMRC Ideas Grant APP2004288 (2021-2024). Role: CIB. Resolving eosinophil and inflammatory heterogeneity in chronic allergic airway disease for safer, effective and lasting precision therapies.
The Hospital Research Foundation Mid-Career Fellowship (01 Jan 2019-31 Dec 2021) - Role: Sole CI. Toward personalised medicine for allergic inflammation and harnessing allergic pathways to treat cancer.
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