Dr Cynthia Bottema
School of Animal and Veterinary Sciences
College of Science
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Cynthia Bottema is an Associate Professor at the University of Adelaide in the School of Animal & Veterinary Sciences. Her expertise is in molecular genetics, DNA testing, biotechnology, and lipid biochemistry, particularly as applied to animal science and livestock production. Cindy received her PhD in Microbial Physiology at Oregon State University. Upon completion of a post-doctoral fellowship at Stanford University, Cindy was appointed as a human molecular genetics research associate at the Mayo Clinic. In 1992, Cindy took a position at the University of Adelaide as the JS Davies Professorial Research Fellow in cattle molecular genetics and in 2000, became a tenured academic at the University of Adelaide. Since 2000, Cindy has had several educational roles in the University including acting as the Animal Science Honours Coordinator, Animal Science, Program Coordinator, the School Associate Head of Staff, the Head of the Animal & Veterinary Biosciences Department and a member of the School Executive Committee. Cindy’s teaching interests include genetics, molecular genetics, biotechnology, biochemistry, and microbiology. Her research interests are in livestock molecular genetics and include the genome organization of Bovidae, genome mapping in Bovidae and genetics of lipid metabolism in cattle. Cindy served on the Executive Committee of the International Society of Animal Genetics for many years.
PREVIOUS RESEARCH INTERESTS
Sterol metabolism in yeast. Projects included:
- Characterisation of the enzyme 14D-sterol reductase in the ergosterol biosynthetic pathway of fungi.
- Quantitation and analysis of sterols in yeast mitochondria and plasma membranes.
- Thermotropic and enzymatic studies on yeast membranes with altered sterol compositions.
Steroid binding in yeast. Projects included:
- Characterisation and purification of an estrogen binding protein in the yeast Saccharomyces cerevisiae.
- Isolation and characterisation of ligands of the yeast estrogen binding protein.
- Comparative studies of mammalian estrogen receptors from tissue culture and rats.
Molecular genetics of human disease. Projects included:
- Delineation and characterisation of mutations in the factor IX gene of haemophilia B patients.
- Analysis of the pattern of germline mutations, mutation rates and evolutionary conservation in humans by population-based molecular genetic studies.
- Development of PCR and sequencing techniques for DNA and RNA diagnostics, RFLP analysis and direct carrier testing.
Genome organisation of Bovidae. Projects included:
- Isolation and characterisation of centromeric and interspersed repetitive DNA sequences from cattle and sheep.
- Characterisation of Robertsonian translocations in cattle by in situ hybridisation using centromeric probes.
- Development of comparative physical gene maps for cattle, sheep, goat and deer by fluorescence in situ hybridisation (FISH) using ovine bacterial artificial chromosome (BAC) clones.
- Development of low cost methodologies for parentage testing in cattle and sheep.
CURRENT RESEARCH INTERESTS
Genome mapping in Bovidae. Projects include:
- Mapping quantitative trait loci (QTL) in cattle for meat quality, particularly fat and muscle metabolic traits.
- Isolation and characterisation of genes involved in ruminant lipid metabolism and deposition.
- Isolation and characterisation of genes involved in cattle net feed efficiency.
- Development of molecular marker techniques for livestock applications.
Genetics of lipid metabolism in cattle. Projects include:
- Analysis of the fatty acid composition in the phospholipids and triacylglycerols of muscle and adipose tissues in different cattle breeds.
- Delineation of carotenoid uptake and deposition in bovine adipose tissue.
- Elucidation of genetics controlling intramuscular fat variation in cattle breeds.
- Determination of effects of vitamin A on adipogenesis in Bovidae.
| Date | Position | Institution name |
|---|---|---|
| 1992 - ongoing | Associate Professor | University of Adelaide |
| Date | Institution name | Country | Title |
|---|---|---|---|
| University of Colorado | USA | BA (major: Molecular, Cellular & Developmental Biology) | |
| Oregon State University | USA | PhD |
| Year | Citation |
|---|---|
| 2025 | Paez, S., Mapholi, N. O., Nesengani, L. T., Lamont, S. J., Aggrey, S. E., Hanotte, O., . . . Gill, C. A. (2025). Supporting social justice through equity-based actions for a sustainable future in animal genetics (at the 39th International Society for Animal Genetics Conference). Animal Genetics, 56(1), 7 pages. |
| 2025 | Pineda, P. S., MacPhillamy, C., Ren, Y., Chen, T., Zhong, L., Adelson, D. L., . . . Low, W. Y. (2025). Insights into natural neocentromere evolution from a cattle T2T X chromosome. Nature Communications, 16(1), 16 pages. |
| 2024 | Yao, J., Bottema, C. D. K., & Khatkar, M. S. (2024). Meta-assembly of genomic associations to identify cattle fat depot candidate genes and pleiotropic effects.. BMC Genomics, 25(1), 1242. |
| 2024 | Aldersey, J. E., Chen, T., Petrovski, K., Williams, J. L., & Bottema, C. D. K. (2024). Histological characterisation of the horn bud region in 58 day old bovine fetuses.. The International journal of developmental biology, 68(3), 117-126. Scopus3 WoS3 Europe PMC3 |
| 2023 | Hue, D. T., Petrovski, K., Chen, T., Williams, J. L., & Bottema, C. D. K. (2023). Analysis of immune-related microRNAs in cows and newborn calves. Journal of Dairy Science, 106(4), 2866-2878. Scopus10 WoS7 Europe PMC6 |
| 2023 | Aldersey, J. E., Liu, N., Tearle, R., Low, W. Y., Breen, J., Williams, J. L., & Bottema, C. D. K. (2023). Topologically associating domains in the POLLED region are the same for Angus- and Brahman-specific Hi-C reads from F1 hybrid fetal tissue.. Anim Genet, 54(4), 536-543. Scopus1 WoS1 Europe PMC1 |
| 2023 | Van, T. D., Hue, D. T., Bottema, C. D. K., Weird, G. M., Skirving, R., & Petrovski, K. R. (2023). Meta-Analysis on the Prevalence of Failed Transfer of Passive Immunity in Calves from Pasture-Based Dairy Farms in Australasia. Animals, 13(11), 1792-1-1792-13. Scopus3 WoS3 |
| 2023 | Tian, R., Kharrati-Koopaee, H., Asadollahpour Nanaie, H., Wang, X., Zhao, M., Li, H., . . . Bottema, C. D. K. (2023). Comparative metabolomics analysis shows key metabolites as potential biomarkers for selection of beef fat colour. Animal Production Science, 63(11), 1063-1067. Scopus3 WoS3 |
| 2022 | Tamlin, V. S., Bottema, C. D. K., Woolford, L., Dobson, E. C., Kessell, A. E., & Peaston, A. E. (2022). Canine mast cell tumours part I: Clinical and survival outcomes.. Veterinary medicine and science, 8(4), 1409-1420. Scopus8 WoS7 Europe PMC7 |
| 2022 | Skirving, R., Bottema, C. D. K., Laven, R., Hue, D. T., & Petrovski, K. R. (2022). Incidence of Inadequate Transfer of Passive Immunity in Dairy Heifer Calves in South Australia. Animals, 12(21), 2912-1-2912-10. Scopus3 WoS3 Europe PMC2 |
| 2021 | Tamlin, V. S., Bottema, C. D. K., Campbell-Ward, M. L., Hanshaw, D., & Peaston, A. E. (2021). KIT mutations in mast cell tumours from cheetahs (Acinonyx jubatus) and domestic cats (Felis catus).. Vet Comp Oncol, 19(2), 381-392. Scopus4 WoS4 Europe PMC4 |
| 2021 | Hue, D. T., Skirving, R., Chen, T., Williams, J. L., Bottema, C. D. K., & Petrovski, K. (2021). Colostrum source and passive immunity transfer in dairy bull calves. Journal of Dairy Science, 104(7), 8164-8176. Scopus18 WoS14 Europe PMC11 |
| 2021 | Hue, D. T., Williams, J. L., Petrovski, K., & Bottema, C. D. K. (2021). Predicting colostrum and calf blood components based on refractometry. Journal of Dairy Research, 88(2), 194-200. Scopus14 WoS13 Europe PMC10 |
| 2020 | Hiendleder, S., Bottema, C. D. K., & Brunner, R. M. (2020). Nuclear mitochondrial pseudogenes in the cattle genome. Animal Genetics, 51(1), 148-149. Scopus1 WoS2 Europe PMC1 |
| 2020 | Tamlin, V. S., Bottema, C. D. K., & Peaston, A. E. (2020). Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment.. Veterinary medicine and science, 6(1), 3-18. Scopus27 WoS23 Europe PMC20 |
| 2020 | Bottema, M. J., Kruk, Z. A., Gontar, A., Pitchford, W. S., & Bottema, C. D. K. (2020). Evidence of marbling as a single connected entity in beef striploins.. Meat Sci, 161, 108004. Scopus10 WoS8 Europe PMC6 |
| 2020 | Aldersey, J. E., Sonstegard, T. S., Williams, J. L., & Bottema, C. D. K. (2020). Understanding the effects of the bovine POLLED variants. Animal Genetics, 51(2), 166-176. Scopus33 WoS28 Europe PMC22 |
| 2018 | Kruk, Z., Bottema, M., Reyes-Veliz, L., Forder, R., Pitchford, W., & Bottema, C. (2018). Vitamin A and marbling attributes: intramuscular fat hyperplasia effects in cattle. Meat Science, 137, 139-146. Scopus41 WoS38 Europe PMC28 |
| 2018 | Herd, R., Arthur, P., Bottema, C., Egarr, A., Geesink, G., Lines, D., . . . Pitchford, W. (2018). Genetic divergence in residual feed intake affects growth, feed efficiency, carcass and meat quality characteristics of Angus steers in a large commercial feedlot. Animal Production Science, 58(1), 164-174. Scopus22 WoS22 |
| 2018 | Lines, D., Pitchford, W., Bottema, C., Herd, R., & Oddy, V. (2018). Selection for residual feed intake affects appetite and body composition rather than energetic efficiency. Animal Production Science, 58(1), 175-184. Scopus42 WoS39 |
| 2015 | FAANG Consortium., Andersson, L., Archibald, A., Bottema, C., Brauning, R., Burgess, S., . . . Zhou, H. (2015). Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project. Genome Biology, 16(1), 57-1-57-6. Scopus256 WoS250 Europe PMC234 |
| 2015 | Rosenblatt, A., Hill, P., Davies, S., Webster, N., Lappalainen, A., Bottema, C., & Caraguel, C. (2015). Precision of spinal radiographs as a screening test for intervertebral disc calcification in Dachshunds. Preventive Veterinary Medicine, 122(1-2), 164-173. Scopus5 WoS5 Europe PMC3 |
| 2014 | Rosenblatt, A., Bottema, C., & Hill, P. (2014). Radiographic scoring for intervertebral disc calcification in the Dachshund. The Veterinary Journal, 200(3), 355-361. Scopus10 WoS9 Europe PMC8 |
| 2014 | Chang, L., Pitchford, W., & Bottema, C. (2014). Modeling tenderness for genetic and quantitative trait loci analyses. Journal of Animal Science, 92(1), 39-47. Scopus3 WoS2 Europe PMC1 |
| 2013 | Morris, C., Bottema, C., Cullen, N., Hickey, S., Knowles, S., & Pitchford, W. (2013). Effects of quantitative trait loci and the myostatin locus on trace and macro elements (minerals) in bovine liver, muscle and kidney. Animal Genetics, 44(4), 361-368. Scopus7 WoS7 Europe PMC7 |
| 2012 | Tian, R., Cullen, N., Morris, C., Fisher, P., Pitchford, W., & Bottema, C. (2012). Major effect of retinal short-chain dehydrogenase reductase (RDHE2) on bovine fat colour. Mammalian Genome, 23(5-6), 378-386. Scopus12 WoS11 Europe PMC7 |
| 2011 | Esmailizadeh Koshkoih, A., Morris, C., Cullen, N., Kruk, Z., Lines, D., Hickey, S., . . . Pitchford, W. (2011). Genetic mapping of quantitative trait loci for meat quality and muscle metabolic traits in cattle. Animal Genetics, 42(6), 592-599. Scopus13 WoS11 Europe PMC9 |
| 2011 | Abdolmohammadi, A., Atashi, H., Zamani, P., & Bottema, C. (2011). High resolution melting as an alternative method to genotype diacylglycerol O-acyltransferase 1 (DGAT1) K232A polymorphism in cattle. Czech Journal of Animal Science, 56(8), 370-376. Scopus12 WoS12 |
| 2010 | Morris, C., Bottema, C., Cullen, N., Hickey, S., Esmailizadeh, A., Siebert, B., & Pitchford, W. (2010). Quantitative trait loci for organ weights and adipose fat composition in Jersey and Limousin back-cross cattle finished on pasture or feedlot. Animal Genetics, 41(6), 589-596. Scopus27 WoS28 Europe PMC22 |
| 2010 | Pisani, D., Bottema, C., Butori, C., Dani, C., & Dechesne, C. (2010). Mouse model of skeletal muscle adiposity: A glycerol treatment approach. Biochemical and Biophysical Research Communications, 396(3), 767-773. Scopus61 WoS58 Europe PMC54 |
| 2010 | Tian, R., Pitchford, W., Morris, C., Cullen, N., & Bottema, C. (2010). Genetic variation in the β, β-carotene-9′, 10′-dioxygenase gene and association with fat colour in bovine adipose tissue and milk. Animal Genetics, 41(3), 253-259. Scopus65 WoS59 Europe PMC48 |
| 2009 | Morris, C., Pitchford, W., Cullen, N., Esmailizadeh Koshkoih, A., Hickey, S., Hyndman, D., . . . Bottema, C. (2009). Quantitative trait loci for live animal and carcass composition traits in Jersey and Limousin back-cross cattle finished on pasture or feedlot. Animal Genetics, 40(5), 648-654. Scopus19 WoS21 Europe PMC16 |
| 2009 | Lines, D., Pitchford, W., Kruk, Z., & Bottema, C. (2009). Limousin myostatin F94L variant affects semitendinosus tenderness. Meat Science, 81(1), 126-131. Scopus22 WoS19 Europe PMC13 |
| 2008 | Esmailizadeh, A., Bottema, C., Sellick, G., Verbyla, A., Morris, C., Cullen, N., & Pitchford, W. (2008). Effects of the myostatin F94L substitution on beef traits. Journal of Animal Science, 86(5), 1038-1046. Scopus82 WoS79 Europe PMC51 |
| 2008 | Kurk, Z., Bottema, C., Davis, J., Siebert, B., Harper, G., Di, J., & Pitchford, W. (2008). Effects of vitamin A on growth performance and carcass quality in steers. Livestock Science, 119(1-3), 12-21. Scopus39 WoS31 |
| 2007 | Sellick, G., Pitchford, W., Morris, C., Cullen, N., Crawford, A., Raadsma, H., & Bottema, C. (2007). Effect of myostatin F94L on carcass yield in cattle. Animal Genetics, 38(5), 440-446. Scopus61 WoS60 Europe PMC36 |
| 2007 | Morris, C., Cullen, N., Glass, B., Hyndman, D., Manley, T., Hickey, S., . . . Lee, M. (2007). Fatty acid synthase effects on bovine adipose fat and milk fat. Mammalian Genome, 18(1), 64-74. Scopus132 WoS129 Europe PMC94 |
| 2006 | Reverter, A., Hudson, N., Wang, Y., Tan, S., Barris, W., Byrne, K., . . . Dalrymple, B. (2006). A gene coexpression network for bovine skeletal muscle inferred from microarray data. Physiological Genomics, 28(1), 76-83. Scopus30 WoS27 Europe PMC23 |
| 2006 | Morris, C., Cullen, N., Hickey, S., Dobbie, P., Veenvliet, B., Manley, T., . . . Wilson, T. (2006). Genotypic effects of calpain 1 and calpastatin on the tenderness of cooked M. longissimus dorsi steaks from Jersey x Limousin, Angus and Hereford-cross cattle. Animal Genetics, 37(4), 411-414. Scopus68 WoS68 Europe PMC35 |
| 2006 | Siebert, B., Kruk, Z., Davis, J., Pitchford, W., Harper, G., & Bottema, C. (2006). Effect of low vitamin a status on fat deposition and fatty acid desaturation in beef cattle. Lipids, 41(4), 365-370. Scopus41 WoS37 Europe PMC25 |
| 2006 | Beever, J., Smit, M., Meyers, S., Hadfield, T., Bottema, C., Albretsen, J., & Cockett, N. (2006). A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep. Animal Genetics, 37(1), 66-71. Scopus60 WoS48 Europe PMC41 |
| 2005 | Kruk, Z., & Bottema, C. (2005). The guts of the matter: dietary regulation of intestinal gene expression. Recent Advances in Animal Nutrition in Australia, 15, 87-93. |
| 2005 | Yu, S., Kim, J., Chung, H., Jung, K., Lee, Y., Yoon, D., . . . Lee, J. (2005). Molecular cloning and characterization of bovine PRKAG3 gene: structure, expression and single nucleotide polymorphism detection. Journal of Animal Breeding and Genetics-zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 122(5), 294-301. Scopus14 WoS12 Europe PMC4 |
| 2004 | Kuchel, H., Siebert, B., Bottema, C., Webb, G., Crawford, A., Duncan, S., . . . Pitchford, W. (2004). Physical mapping of the stearoyl-CoA desaturase (SCD) locus in sheep. Animal Genetics, 35(2), 163. Scopus7 WoS7 Europe PMC3 |
| 2004 | Hebart, M., Pitchford, W., Arthur, P., Archer, J., Herd, R., & Bottema, C. (2004). Effect of missing data on the estimate of average daily feed intake in beef cattle. Australian Journal of Experimental Agriculture, 44(4-5), 415-421. Scopus11 WoS10 Europe PMC4 |
| 2003 | Siebert, B., Pitchford, W., Kruk, Z., Kuchel, H., Deland, M., & Bottema, C. (2003). Differences in Δ⁹ desaturase activity between Jersey- and Limousin-sired cattle. Lipids, 38(5), 539-543. Scopus40 WoS38 Europe PMC25 |
| 2003 | Pal, S., Thomson, A., Bottema, C., & Roach, P. (2003). α-Tocopherol modulates the low density lipoprotein receptor of human HepG2 cells-Tocopherol modulates the low density lipoprotein receptor of human HepG2 cells. Nutrition Journal, 2(1), 3-13. Scopus24 WoS24 Europe PMC13 |
| 2002 | Afolayan, R., Deland, M., Rutley, D., Bottema, C., Ewers, A., Ponzoni, R., & Pitchford, W. (2002). Prediction of carcass meat, fat and bone yield across diverse cattle genotypes using live-animal measurements. Animal Production, 24, 13-16. |
| 2002 | Kurar, E., Barendse, W., Bottema, C., Davis, S., Foster, M., Kalm, E., . . . Kirkpatrick, B. (2002). Concensus and comprehensive linkage maps of bovine chromosome 24. Animal Genetics, 33(6), 460-463. Scopus5 WoS4 Europe PMC4 |
| 2002 | Afolayan, R., Pitchford, W., Weatherly, A., & Bottema, C. (2002). Genetic variation in growth and body dimensions of Jersey and Limousin cross cattle. 2. Post-weaning dry and wet season performance. Asian-Australasian Journal of Animal Sciences, 15(10), 1378-1385. Scopus6 WoS3 |
| 2002 | Afolayan, R., Pitchford, W., Weatherly, A., & Bottema, C. (2002). Genetic variation in growth and body dimensions of Jersey and Limousin cross cattle. 1. Pre-weaning performance. Asian-Australasian Journal of Animal Sciences, 15(10), 1371-1377. Scopus8 WoS5 |
| 2002 | Pitchford, W., Deland, M., Siebert, B., Malau-Aduli, A., & Bottema, C. (2002). Genetic variation in fatness and fatty acid composition of crossbred cattle. Journal of Animal Science, 80(11), 2825-2832. Scopus127 WoS120 Europe PMC83 |
| 2002 | Kruk, Z., Pitchford, W., Siebert, B., Deland, M., & Bottema, C. (2002). Factors affecting estimation of marbling in cattle and the relationship between marbling scores and intramuscular fat. Animal Production, 24, 129-132. |
| 2002 | Pal, S., Thomson, A., Bottema, C., & Roach, P. (2002). Polyunsaturated fatty acids downregulate the low density lipoprotein receptor of human HepG2 cells. Journal of Nutritional Biochemistry, 13(1), 55-63. Scopus16 WoS15 Europe PMC15 |
| 2001 | Wheeler, D., Hope, R., Cooper, S., Dolman, G., Webb, G., Bottema, C., . . . Holland, R. (2001). An orphaned mammalian b-globin gene of ancient evolutionary origin. Proceedings of the National Academy of Sciences of the United States of America, 98(3), 1101-1106. Scopus45 WoS45 Europe PMC33 |
| 2001 | Bursill, C., Roach, P., Bottema, C., & Pal, S. (2001). Green tea upregulates the low-density lipoprotein receptor through the sterol-regulated element binding protein in HepG2 liver cells. Journal of Agricultural and Food Chemistry, 49(11), 5639-5645. Scopus60 WoS44 Europe PMC36 |
| 2001 | Bouillet, P., Zhang, L., Huang, D., Webb, G., Bottema, C., Shore, P., . . . Adams, J. (2001). Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mammalian Genome, 12(2), 163-168. Scopus133 WoS128 Europe PMC116 |
| 2001 | Coulthard, M., Lickliter, J., Subanesan, N., Chen, K., Webb, G., Lowry, A., . . . Boyd, A. (2001). Characterization of the EphA1 receptor tyrosine kinase: Expression in epithelial tissues. Growth Factors, 18(4), 303-317. Scopus48 WoS43 Europe PMC36 |
| 2001 | Travers, M., Vallance, A., Gourlay, H., Gill, C., Klein, I., Bottema, C., & Barber, M. (2001). Promoter I of the ovine acetyl-CoA carboxylase-a gene: an E-box motif at - 114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes. Biochemical Journal, 359(Part 2), 273-284. |
| 2001 | Casas, E., Sonstegard, T., Barendse, W., Bennett, G., Bottema, C., Crawford, A., . . . Xu, N. (2001). Comprehensive linkage map of bovine chromosome 27. Animal Genetics, 32(2), 95-97. Scopus4 WoS4 Europe PMC3 |
| 2001 | Casas, E., Bennett, G., Bottema, C., Crawford, A., Kalm, E., Kappes, S., . . . Xu, N. (2001). Comprehensive linkage map of bovine chromosome 11. Animal Genetics, 32(2), 92-94. Scopus3 WoS2 Europe PMC2 |
| 2000 | Siebert, B., Pitchford, W., Kuchel, H., Kruk, Z., & Bottema, C. (2000). The Effect of b-carotene on desaturation of ruminant fat. Asian-Australasian Journal of Animal Sciences, 13(SUPPL. A), 185-188. Scopus6 |
| 2000 | Morris, C., Cullen, N., Bottema, C., Crawford, A., Hyndman, D., & Pitchford, W. (2000). Preliminary beef carcass composition data from breed crosses in a genetic marker trial. New Zealand Society of Animal Production Proceedings, 60, 113-114. |
| 2000 | Malau-Aduli, A., Edriss, M., Siebert, B., Bottema, C., Deland, M., & Pitchford, W. (2000). Estimates of genetic parameters for triacylglycerol fatty acids in beef cattle at weaning and slaughter. Journal of Animal Physiology and Animal Nutrition-Zeitschrift fur Tierphysiologie Tierernahrung und Futtermittelkunde, 83(4-5), 169-180. Scopus16 WoS15 |
| 2000 | Malau-Aduli, A., Siebert, B., Bottema, C., & Pitchford, W. (2000). Heterosis, sex and breed differences in the fatty acid composition of muscle phospholipids in beef cattle. Journal of Animal Physiology and Animal Nutrition-Zeitschrift fur Tierphysiologie Tierernahrung und Futtermittelkunde, 83(3), 113-120. Scopus17 WoS16 |
| 2000 | Malau-Aduli, A., Edriss, M., Siebert, B., Bottema, C., & Pitchford, W. (2000). Breed differences and heterosis in triacylglycerol fatty acid composition of bovine adipose tissue. Journal of Animal Physiology and Animal Nutrition-Zeitschrift fur Tierphysiologie Tierernahrung und Futtermittelkunde, 83(2), 106-112. Scopus11 WoS11 |
| 2000 | Malau-Aduli, A., Edriss, M., Siebert, B., Bottema, C., & Pitchford, W. (2000). Breed differences and genetic parameters for melting point, marbling score and fatty acid composition of lot-fed cattle. Journal of Animal Physiology and Animal Nutrition-Zeitschrift fur Tierphysiologie Tierernahrung und Futtermittelkunde, 83(2), 95-105. Scopus32 WoS29 |
| 2000 | Maddox, J. F., Andrews, A. E., Gill, C. A., & Bottema, C. D. K. (2000). Linkage and physical mapping of the sheep perforin (PRF1) gene to OAR 25. Animal Genetics, 31(3), 231-232. Scopus1 WoS1 Europe PMC2 |
| 2000 | Pitchford, W. S., & Bottema, C. D. K. (2000). Genetic effects on growth and development in Jersey and Limousin cross cattle. Asian Australasian Journal of Animal Sciences, 13(SUPPL. A), 485-488. Scopus1 |
| 2000 | Duivestein, J., Pitchford, W., Bottema, C., Fassbender, R., Cusack, D., & Meldrum, R. (2000). Detection of vertical fiber hide defect (VFHD) in Hereford cattle hides by biopsy. Journal of the American Leather Chemists Association, 95(3), 92-101. WoS1 |
| 1999 | Koukoulas, I., Webb, G., Bottema, C., Gill, C., Johnston, C., & Aldred, G. (1999). Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23-24 of sheep chromosome 3 and cattle chromosome 5. Gene, 240(1), 183-192. Scopus5 WoS5 Europe PMC5 |
| 1999 | Gill, C., Davis, S., Taylor, J., Cockett, N., & Bottema, C. (1999). Construction and characterizaton of an ovine bacterial artificial chromosome library. Mammalian Genome, 10(11), 1108-1111. Scopus19 WoS20 Europe PMC15 |
| 1998 | Malau-Aduli, A., Siebert, B., Bottema, C., & Pitchford, W. (1998). Breed Comparison of the Fatty Acid Composition of Muscle Phospholipids in Jersey and Limousin Cattle. Journal of Animal Science, 76(3), 766-774. Scopus124 WoS118 Europe PMC59 |
| 1998 | Parsons, Y., Webb, G., & Bottema, C. (1998). Assignment of the growth hormone receptor gene to band q17 of the homoeologous sheep 16 and cattle 20 chromosomes. Mammalian Genome, 9(7), 599-600. Scopus6 WoS6 Europe PMC4 |
| 1997 | Soon, L., Bottema, C., & Breed, W. (1997). Atomic force microscopy and cytochemistry of chromatin from marsupial spermatozoa with special reference to Sminthopsis crassicaudata. Molecular Reproduction and Development, 48(3), 367-374. Scopus8 WoS8 Europe PMC5 |
| 1997 | Jacoby, A., Webb, G., Liu, M., Kofler, B., Hort, Y., Fathi, Z., . . . Iismaa, T. (1997). Structural organization of the mouse and human GALR1 Galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. Genomics, 45(3), 496-508. Scopus35 WoS33 Europe PMC24 |
| 1997 | Webb, G., Jitrapakdee, S., Bottema, C., & Wallace, J. (1997). Assignment of the pyruvate carboxylase gene to rat chromosome band 1q43 by in situ hybridization. Cytogenetics and Cell Genetics, 79(1-2), 151-152. Scopus9 WoS8 Europe PMC3 |
| 1997 | Malau-Aduli, A., Siebert, B., Bottema, C., & Pitchford, W. (1997). A comparison of the fatty acid composition of triacylglycerols in adipose tissue from Limousin and Jersey cattle. Australian Journal of Agricultural Research, 48(5), 715-722. Scopus161 WoS145 |
| 1997 | Chapman, G., Remiszewski, J., Webb, G., Schulz, T., Bottema, C., & Rathjen, P. (1997). The Mouse Homeobox Gene, Gbx2: Genomic Organisation and Expression in Pluripotent Cells in Vitro and in Vivo. Genomics, 46(2), 223-233. Scopus38 WoS38 Europe PMC33 |
| 1997 | Pal, S., Bottema, C. D. K., & Roach, P. D. (1997). The effects of polyunsaturated fatty acids and vitamins on the expression of the low density lipoprotein receptor in human HepG2 hepatoma cells. ATHEROSCLEROSIS, 134(1-2), 361. |
| 1996 | Andersson, L., Bottema, C., Broad, T., Gill, T., & Graves, J. (1996). Comparative Genome Organisation of Vertebrates. Mammalian Genome, 7(10), 717-734. Scopus140 WoS118 Europe PMC87 |
| 1996 | Bernard, O., Burkitt, V., Webb, G., Bottema, C., Nicholl, J., Sutherland, G., & Matthew, P. (1996). Structure and chromosomal localization of the genomic locus encoding the Kiz1 LIM-Kinase gene. Genomics, 35(3), 593-596. Scopus13 WoS12 Europe PMC11 |
| 1995 | Bottema, C. (1995). Genetic testing comes of age. Outlook on Agriculture, 24(4), 203-205. |
| 1993 | Dutton, C. M., Bottema, C. D. K., & Sommer, S. S. (1993). Alu repeats in the human factor IX gene: The rate of polymorphism is not substantially elevated. Human Mutation, 2(6), 468-472. Scopus3 WoS3 Europe PMC4 |
| 1993 | Bottema, C. D. K., & Sommer, S. S. (1993). PCR amplification of specific alleles: Rapid detection of known mutations and polymorphisms. Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis, 288(1), 93-102. Scopus110 WoS108 Europe PMC74 |
| 1993 | Gostout, B., Vielhaber, E., Ketterling, R. P., Yoon, H. S., Bottema, C. D. K., Kasper, C. K., . . . Sommer, S. S. (1993). Germline mutations in the factor IX gene: A comparison of the pattern in caucasians and non-caucasians. Human Molecular Genetics, 2(3), 293-298. Scopus25 WoS28 Europe PMC24 |
| 1993 | Bottema, C. D. K., Ketterling, R. P., Vielhaber, E., Yoon, H. S., Gostout, B., Jacobson, D. P., . . . Sommer, S. S. (1993). The pattern of spontaneous germ-line mutation: relative rates of mutation at or near CpG dinucleotides in the factor IX gene. Human Genetics, 91(5), 496-503. Scopus47 WoS47 Europe PMC33 |
| 1993 | Bottema, C. D. K., Sarkar, G., Cassady, J. D., Ii, S., Dutton, C. M., & Sommer, S. S. (1993). Polymerase Chain Reaction Amplification of Specific Alleles: A General Method of Detection of Mutations, Polymorphisms, and Haplotypes. Methods in Enzymology, 218(C), 388-402. Scopus65 WoS64 Europe PMC44 |
| 1993 | Ketterling, R. P., Vielhaber, E., Bottema, C. D. K., Schaid, D. J., Cohen, M. P., Sexauer, C. L., & Sommer, S. S. (1993). Germ-line origins of mutation in families with hemophilia B: The sex ratio varies with the type of mutation. American Journal of Human Genetics, 52(1), 152-166. Scopus75 WoS79 Europe PMC54 |
| 1992 | Sommer, S. S., Bowie, E. J. W., Ketterling, R. P., & Bottema, C. D. K. (1992). Missense mutations and the magnitude of functional deficit: the example of factor IX. Human Genetics, 89(3), 295-297. Scopus22 WoS19 Europe PMC15 |
| 1992 | Sommer, S. S., Groszbach, A. R., & Bottema, C. D. K. (1992). PCR amplification of specific alleles (PASA) is a general method for rapidly detecting known single-base changes. Biotechniques, 12(1), 82-87. Scopus201 WoS207 Europe PMC128 |
| 1992 | KETTERLING, R., BOTTEMA, C. D. K., VIELHABER, E., & SOMMER, S. S. (1992). DIRECT CARRIER DETECTION FOR HEMOPHILIA-B - EXPERIENCE WITH 140 FAMILIES. TRANSFUSION, 32(5), 486. |
| 1991 | Bottema, C. D. K., Ketterling, R. P., Ii, S., Yoon, H. S., Phillips, J. A., & Sommer, S. S. (1991). Missense mutations and evolutionary conservation of amino acids: Evidence that many of the amino acids in factor IX function as "spacer" elements. American Journal of Human Genetics, 49(4), 820-838. Scopus100 WoS103 Europe PMC72 |
| 1991 | Bottema, C. D. K., Bottema, M. J., Ketterling, R. P., Yoon, H. S., Janco, R. L., Phillips, J. A., & Sommer, S. S. (1991). Why does the human factor IX gene have a G + C content of 40%?. American Journal of Human Genetics, 49(4), 839-850. Scopus48 WoS50 Europe PMC34 |
| 1991 | Ketterling, R. P., Bottema, C. D. K., Koeberl, D. D., Ii, S., & Sommer, S. S. (1991). T296→M, a common mutation causing mild hemophilia B in the Amish and others: founder effect, variability in factor IX activity assays, and rapid carrier detection. Human Genetics, 87(3), 333-337. Scopus28 WoS30 Europe PMC22 |
| 1991 | BOTTEMA, C. D. K., KETTERLING, R. P., II, S., YOON, H. S., AXELSEN, P. H., PHILLIPS, J. A., & SOMMER, S. S. (1991). MISSENSE MUTATIONS AND EVOLUTIONARY CONSERVATION OF AMINO-ACIDS - EVIDENCE THAT MANY OF THE AMINO-ACIDS IN FACTOR-IX FUNCTION AS SPACER ELEMENTS. AMERICAN JOURNAL OF HUMAN GENETICS, 49(4), 462. WoS1 |
| 1991 | Ketterling, R. P., Bottema, C. D. K., Phillips, J. A., & Sommer, S. S. (1991). Evidence that descendants of three founders constitute about 25% of hemophilia B in the united states. Genomics, 10(4), 1093-1096. Scopus53 WoS52 Europe PMC44 |
| 1991 | BOTTEMA, C. D. K., PHILLIPS, J. A., & SOMMER, S. S. (1991). MISSENSE MUTATIONS AND MILD HEMOPHILIA B. AMERICAN JOURNAL OF HUMAN GENETICS, 49(4), 15. |
| 1991 | BOTTEMA, C. D. K., BOTTEMA, M. J., KETTERLING, R. P., YOON, H. S., JANCO, R. L., PHILLIPS, J. A., & SOMMER, S. S. (1991). WHY DOES THE HUMAN FACTOR-IX GENE HAVE A G+C CONTENT OF 39 PERCENT. AMERICAN JOURNAL OF HUMAN GENETICS, 49(4), 494. |
| 1990 | Bottema, C. D. K., Koeberl, D. D., Ketterling, R. P., Bowie, E. J. W., Taylor, S. A. M., Lillicrap, D., . . . Sommer, S. S. (1990). A past mutation at Isoleucine397 is now a common cause of moderate/mild haemophilia B. British Journal of Haematology, 75(2), 212-216. Scopus32 WoS35 Europe PMC30 |
| 1990 | Bottema, C. D. K., Ketterling, R. P., Koeberl, D. D., Taylor, S. A., & Sommer, S. S. (1990). Mutations at arginine residues in two Asian hemophilia B patients. Nucleic Acids Research, 18(7), 1924. Scopus8 WoS8 Europe PMC8 |
| 1990 | Bottema, C. D. K., Ketterling, R. P., Yoon, H. S., & Sommer, S. S. (1990). The pattern of factor IX germ-line mutation in asians is similar to that of caucasians. American Journal of Human Genetics, 47(5), 835-841. Scopus45 WoS48 Europe PMC39 |
| 1990 | Koeberl, D. D., Bottema, C. D. K., & Sommer, S. S. (1990). Comparison of direct and indirect methods of carrier detection in an X-linked disease. American Journal of Medical Genetics, 35(4), 600-608. Scopus6 WoS6 Europe PMC4 |
| 1990 | Koeberl, D. D., Bottema, C. D. K., Ketterling, R. P., Bridge, P. J., Lillicrap, D. P., & Sommer, S. S. (1990). Mutations causing hemophilia B: Direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene. American Journal of Human Genetics, 47(2), 202-217. Scopus129 WoS144 Europe PMC104 |
| 1990 | Sarkar, G., Cassady, J., Bottema, C. D. K., & Sommer, S. S. (1990). Characterization of polymerase chain reaction amplification of specific alleles. Analytical Biochemistry, 186(1), 64-68. Scopus146 WoS154 Europe PMC90 |
| 1990 | Koeberl, D. D., Bottema, C. D. K., Sarkar, G., Ketterling, R. P., Chen, S. H., & Sommer, S. S. (1990). Recurrent nonsense mutations at arginine residues cause severe hemophilia B in unrelated hemophiliacs. Human Genetics, 84(5), 387-390. Scopus32 WoS34 Europe PMC27 |
| 1990 | SOMMER, S. S., BOTTEMA, C. D. K., KOEBERL, D. D., & KETTERLING, R. P. (1990). DELINEATION BY DIRECT SEQUENCING OF THE MUTATION IN 62 PERSONS WITH HEMOPHILIA-B AND DIRECT CARRIER TESTING IN 58 AT-RISK WOMEN. TRANSFUSION, 30(3), 281. |
| 1989 | BOTTEMA, C. D. K., KOEBERL, D. D., & SOMMER, S. S. (1989). DIRECT CARRIER TESTING IN 14 FAMILIES WITH HAEMOPHILIA-B. LANCET, 2(8662), 526-529. WoS34 Europe PMC21 |
| 1989 | SOMMER, S. S., CASSADY, J. D., SOBELL, J. L., & BOTTEMA, C. D. K. (1989). A Novel Method for Detecting Point Mutations or Polymorphisms and Its Application to Population Screening for Carriers of Phenylketonuria. Mayo Clinic Proceedings, 64(11), 1361-1372. Scopus130 WoS132 Europe PMC80 |
| 1989 | Koeberl, D. D., Bottema, C. D. K., Buerstedde, J. M., & Sommer, S. S. (1989). Functionally important regions of the factor IX gene have a low rate of polymorphism and a high rate of mutation in the dinucleotide CpG. American Journal of Human Genetics, 45(3), 448-457. Scopus95 WoS106 Europe PMC82 |
| 1989 | Bottema, C. D. K., Ketterling, R. P., Cho, H. I., & Sommer, S. S. (1989). Hemophilia B in a male with a four-base insertion that arose in the germline of his mother. Nucleic Acids Research, 17(23), 10139. Scopus13 WoS13 Europe PMC12 |
| 1989 | SOMMER, S. S., KOEBERL, D. D., BOTTEMA, C. D. K., & BUERSTEDDE, J. M. (1989). FUNCTIONALLY IMPORTANT REGIONS OF THE FACTOR-IX GENE HAVE A LOW RATE OF POLYMORPHISM AND A HIGH-RATE OF MUTATION IN THE DINUCLEOTIDE CPG. THROMBOSIS AND HAEMOSTASIS, 62(1), 203. |
| 1986 | Miller, S. C., Bottema, C. D. K., Stathis, P. A., Tokés, L. G., & Feldman, D. (1986). Unexpected presence of estrogens in culture medium supplements: Subsequent metabolism by the yeast sacchromyces cerevisiae. Endocrinology, 119(3), 1362-1369. Scopus16 WoS18 Europe PMC12 |
| 1985 | Parks, L. W., Bottema, C. D. K., Rodriguez, R. J., & Lewis, T. A. (1985). [18] Yeast Sterols: Yeast Mutants as Tools for the Study of Sterol Metabolism. Methods in Enzymology, 111(C), 333-346. Scopus70 WoS81 Europe PMC66 |
| 1985 | Bottema, C. D. K., Rodriguez, R. J., & Parks, L. W. (1985). Influence of sterol structure on yeast plasma membrane properties. Bba Biomembranes, 813(2), 313-320. Scopus26 WoS26 Europe PMC17 |
| 1985 | Rodriguez, R. J., Low, C., Bottema, C. D. K., & Parks, L. W. (1985). Multiple functions for sterols in Saccharomyces cerevisiae. Biochimica Et Biophysica Acta Bba Lipids and Lipid Metabolism, 837(3), 336-343. Scopus200 WoS215 Europe PMC147 |
| 1984 | MCCAMMON, M. T., HARTMANN, M. A., BOTTEMA, C. D. K., & PARKS, L. W. (1984). STEROL METHYLATION IN SACCHAROMYCES-CEREVISIAE. JOURNAL OF BACTERIOLOGY, 157(2), 475-483. WoS50 Europe PMC48 |
| 1983 | Bottema, C. D. K., McLean-Bowen, C. A., & Parks, L. W. (1983). Role of sterol structure in the thermotropic behavior of plasma membranes of Saccharomyces cerevisiae. Bba Biomembranes, 734(2), 235-248. Scopus28 WoS36 |
| 1983 | BOTTEMA, C., & PARKS, L. (1983). Effect of sterol structure on the physical-properties and function of plasma-membranes from yeast. Federation proceedings, 42(7), 1772. |
| 1982 | Parks, L. W., McLean-Bowen, C., Bottema, C. K., Taylor, F. R., Gonzales, R., Jensen, B. W., & Ramp, J. R. (1982). Aspects of sterol metabolism in the yeast Saccharomyces cerevisiae and in Phytophthora. Lipids, 17(3), 187-196. Scopus12 WoS18 Europe PMC9 |
| 1981 | PARKS, L. W., MCLEANBOWEN, C., & BOTTEMA, C. D. K. (1981). EFFECTS OF LIPID ALTERATIONS ON MEMBRANE-PROPERTIES OF S-CEREVISIAE. FEDERATION PROCEEDINGS, 40(6), 1561. |
| 1980 | Bottema, C. K., & Parks, L. W. (1980). Sterol analysis of the inner and outer mitochondrial membranes in yeast. Lipids, 15(12), 987-992. Scopus15 WoS15 |
| 1978 | Bottema, C., & Parks, L. (1978). Δ¹⁴-sterol reductase in Saccharomyces cerevisiae. Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, 531(3), 301-307. Scopus29 WoS37 Europe PMC13 |
| - | Bottema, C., Do, H., Chen, T., Skirving, R., Petrovski, K., & Williams, J. L. (n.d.). Hue, et al. (2021) Colostrum source and passive immunity transfer in dairy bull calves. Journal of Dairy Science paper Supplementary Files. |
| Year | Citation |
|---|---|
| 2024 | Paez, S., Mapholi, N., Nesengani, L. T., Lamont, S., Aggrey, S., Hanotte, O., . . . Gill, C. (2024). Supporting social justice through equity-based actions for a sustainable future in animal genetics (at the 39th International Society for Animal Genetics Conference). DOI |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2023 | Principal Supervisor | Identification of a recessive genetic mutation causing a female sub-fertility in a herd of Limousin cattle | Doctor of Philosophy | Doctorate | Full Time | Miss Rachael Louise Hofmeyer |
| 2023 | Principal Supervisor | Identification of a recessive genetic mutation causing a female sub-fertility in a herd of Limousin cattle | Doctor of Philosophy | Doctorate | Full Time | Miss Rachael Louise Hofmeyer |
| 2022 | Co-Supervisor | Mapping and identification of candidate genes controlling fat related production traits in cattle | Doctor of Philosophy | Doctorate | Full Time | Mr Junpeng Yao |
| 2022 | Co-Supervisor | Mapping and identification of candidate genes controlling fat related production traits in cattle | Doctor of Philosophy | Doctorate | Full Time | Mr Junpeng Yao |
| 2020 | Co-Supervisor | Effects of colostrum intake on fertility and milk production in dairy cattle | Doctor of Philosophy | Doctorate | Part Time | Dr Rebel Skirving |
| 2020 | Co-Supervisor | Effects of colostrum intake on fertility and milk production in dairy cattle | Doctor of Philosophy | Doctorate | Full Time | Dr Rebel Skirving |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2017 - 2021 | Principal Supervisor | Transfer of Colostrum Components to Newborn Calves | Doctor of Philosophy | Doctorate | Full Time | Dr Hue Thi Do |
| 2017 - 2023 | Principal Supervisor | Investigation into the genetic basis of bovine horn development | Doctor of Philosophy | Doctorate | Full Time | Miss Johanna Ellen Aldersey |
| 2016 - 2020 | Principal Supervisor | KIT Mutations in Australian Canine Mast Cell Tumours and Correlations with Patient Prognostic Factors | Doctor of Philosophy | Doctorate | Full Time | Miss Vanessa Tamlin |
| 2015 - 2021 | Co-Supervisor | Application of whole genome sequencing to Australia-wide collections of extraintestinal pathogenic Escherichia coli from companion animals and commensal E. coli from pigs | Doctor of Philosophy | Doctorate | Part Time | Ms Amanda Kidsley |
| 2013 - 2014 | Co-Supervisor | Genetic diversity and measuring genetic parameters for economically import traits in Zambian cattle | Master of Philosophy | Master | Full Time | Mr Ellison Musimuko |
| 2012 - 2012 | Co-Supervisor | Isolation and Characterisation of Tannin-Resistant Bacteria from the Rumen of Feral Goats and Camels | Master of Science | Master | Full Time | Ms Anita Sardiana Tjakradidjaja |
| 2011 - 2017 | Principal Supervisor | Progressing a Scoring Scheme for Intervertebral Disc Clacification Screening in Dachshund Dogs | Master of Philosophy | Master | Part Time | Dr Alana Rosenblatt |
| 2009 - 2016 | Principal Supervisor | Molecular Genetics of Residual Feed Intake and Mitochondrial Function in Cattle | Doctor of Philosophy | Doctorate | Full Time | Mrs Nadiatur Akmar Zulkifli |
| 2007 - 2011 | Principal Supervisor | Molecular Genetics of Cattle Muscularity | Master of Agricultural Science | Master | Full Time | Ms Irida Novianti |
| 2007 - 2012 | Principal Supervisor | Quantitative Trait Loci and Genes Affecting Beef Tenderness | Doctor of Philosophy | Doctorate | Full Time | Mr Lei Yao Chang |
| 2007 - 2012 | Principal Supervisor | Genomic Approach to Understanding Variation in Bovine Fat Colour | Doctor of Philosophy | Doctorate | Full Time | Mr Rugang Tian |
| 2007 - 2016 | Principal Supervisor | Consequences of Selection for Residual Feed Intake | Doctor of Philosophy | Doctorate | Full Time | Mr David Lines |
| 2006 - 2012 | Principal Supervisor | Genetic Independence of Fat Depots in Cattle | Doctor of Philosophy | Doctorate | Full Time | Mr Andrew Egarr |
| 2004 - 2010 | Principal Supervisor | Molecular Characterisation of Primary Wool Follicle Initiation in Merino Sheep | Doctor of Philosophy | Doctorate | Part Time | Dr Hayley McGrice |
| 2003 - 2008 | Principal Supervisor | Identification and Characterization of Genetic Markers and Metabolic Pathways Controlling Net Feed Efficiency in Beef Cattle | Doctor of Philosophy | Doctorate | Full Time | Mr Madan Naik |
| 2003 - 2007 | Co-Supervisor | Multiple Trait Analysis for Genetic Mapping of Quantitative Trait Loci for Carcass and Beef Quality | Doctor of Philosophy | Doctorate | Full Time | Mr Ali Esmailizadeh Koshkoih |
| 1999 - 2003 | Co-Supervisor | Genetics of Growth and Development in Cattle | Doctor of Philosophy | Doctorate | Full Time | Mr Raphael Afolayan |
| 1998 - 2002 | Principal Supervisor | DISCOVERY, ANALYSIS, AND UTILITY OF BOVINE SINGLE NUCLEOTIDE POLYMORPHISMS | Doctor of Philosophy | Doctorate | Part Time | Miss Gabrielle Sellick |
| 1998 - 2004 | Co-Supervisor | Genomics of Feed Efficiency for Livestock | Doctor of Philosophy | Doctorate | Full Time | Dr Michelle Hebart |
| 1995 - 2010 | Co-Supervisor | Comparative Analysis of Two Attachment Variants of Butyrivibrio Fibrisolvens | Doctor of Philosophy | Doctorate | Full Time | Mr Djarot Sasongko Hami Seno |