Cory Xian

Prof Cory Xian

Research Professor

School of Pharmacy and Biomedical Science

College of Health

Available For Media Comment.

Cory is interested in tissue growth and injury repair research. He leads the Bone Growth and Repair Research Group at University of South Australia. He is established as a leading researcher in paediatric bone biology and cancer chemotherapy-induced bone defects. He has more than 170 publications (including journals: J Bone Miner Res, Endocr Rev, Endocrinology, Nat Rev Rheumatol, Hum Mol Genet, Am J Pathol, Am J Physiol Endocr Metab, PloS One, Bone, J Cell Physiol, and Sci Rep). Cory is Managing Editor for Frontiers in Bioscience, Guest Editor for Journal of Molecular Endocrinolology, Guest Editor for International Journal of Endocrinology, and is an editorial board member for 8 other journals including Scientific Reports.
Cory's current research interests: (1) Bone growth mechanisms and regulation; (2) Mechanisms for injury responses and bone growth defects after growth plate fracture; (3) Development of biological treatments (growth factors or stem cells based) for repairing injured growth plate cartilage and for enhancing bone fracture healing; (4) Mechanisms for chemotherapy-induced bone growth arrest and osteoporosis and development of preventative treatments; (5) Improvement of bone health using natural bioactive compounds and nutraceuticals.
Cory is a member of Bone Health Foundation Research Committee (Australia), and a former member of Channel-7 Children's Research Foundation of South Australia Research Committee.

Cory has a long-standing track record in research on tissue growth, injury repair and roles of growth factors. Since 2002, he has focused his research on bone growth, injury and repair, an exciting area of paediatric bone biology that is relatively unexplored and yet scientifically challenging and clinically critically impacting on children’s bone growth, bone mass accumulation, and adult bone health. His group mainly focuses on the following three areas:

(1) Mechanisms of normal bone growth and regulation: We are interested in understanding the mechanisms for the normal bone growth and currently we are focusing on understanding the growth plate biology and regulation of bone lengthening. We are also investigating whether some micro-nutrients can be used to positively modulate bone growth, bone mass accumulation, populations of skeletal stem cells, and adult bone health outcomes (such as osteoporosis and fractures).

(2) Mechanisms for growth plate trauma injury-induced growth defects: Growth plate trauma injury is a common and significant problem as 20% childhood bone fractures involve growth plate and the inured growth plate cartilage is often undesirably repaired by bony tissue leading to growth defects. Cory's group has been investigating cellular and molecular mechanisms for the faulty repair and developing growth factor- and/or stem cell- based repair.

(3) Mechanisms for and prevention of cancer chemotherapy-induced growth defects: While chemotherapy-based cancer treatment is becoming more successful and thus the use of chemotherapy is becoming more intensified, chemotherapy-induced long-term side effects are becoming more obvious as it stunts the bone growth and causes osteoporosis and frequent bone fractures which persists into adulthood. Cory's group is investigating the underlying cellular and molecular mechanisms for the bone growth defects and regeneration potentials of bone and bone marrow. This group also aims to develop supplementary preventative treatment that will preserve bone growth during chemotherapy.

Year Citation
2025 Wang, B., Ge, F., Wang, W., Wang, B., Xian, C. J., & Zhai, Y. (2025). Hydrogel-Based Therapeutic Strategies for Periodontal Tissue Regeneration: Advances, Challenges, and Future Perspectives. Pharmaceutics, 17(11), 25 pages.
DOI
2025 Su, Y. W., Lee, A. M. C., Xu, X., Hua, B., Tapp, H., Wen, X. S., & Xian, C. J. (2025). Correction to: Methotrexate Chemotherapy Causes Growth Impairments, Vitamin D Deficiency, Bone Loss, and Altered Intestinal Metabolism—Effects of Calcitriol Supplementation (Cancers, (2023), 15, 17, (4367), 10.3390/cancers15174367). Cancers, 17(7), 2 pages.
DOI
2025 Li, N., Wang, B., Yang, M., Feng, M., Xu, X., Xian, C. J., . . . Zhai, Y. (2025). The Multi-Target Action Mechanism for the Anti-Periodontitis Effect of Astragali radix Based on Bioinformatics Analysis and In Vitro Verification. Nutrients, 17(4), 23 pages.
DOI
2025 Liu, Z., Cao, Q., Wang, W., Wang, B., Yang, Y., Xian, C. J., . . . Zhai, Y. (2025). The Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research. Microorganisms, 13(1), 22 pages.
DOI Scopus6 WoS4 Europe PMC3
2025 Yang, M., Sun, M., Wang, J., Cao, Q., Xian, C. J., & Zhai, Y. (2025). The Application of Metal Nanoparticles in Oral Inflammatory Diseases. International Dental Journal, 75(6), 13 pages.
DOI
2025 Wei, L., Sun, Y., Li, Y., Xian, C. J., & Wen, X. S. (2025). Steamed root of Rehmannia glutinosa Libosch. relieves methotrexate-induced intestinal mucositis in mice with manninotriose as a core mediator. Carbohydrate Polymer Technologies and Applications, 11(100919), 12 pages.
DOI
2025 Li, N., Yang, M., Feng, M., Xu, X., Li, Y., Zhang, Y., . . . Zhai, Y. (2025). Locally Delivered Hydrogel with Sustained Release of Flavonol Compound Kaempferol Mitigates Inflammatory Progression of Periodontitis and Enhances the Gut Microflora Composition in Rats (vol 11, pg 1646, 2025). ACS BIOMATERIALS SCIENCE & ENGINEERING, 11(5), 3082.
DOI WoS1
2025 Li, N., Yang, M., Feng, M., Xu, X., Li, Y., Zhang, Y., . . . Zhai, Y. (2025). Locally Delivered Hydrogel with Sustained Release of Flavonol Compound Kaempferol Mitigates Inflammatory Progression of Periodontitis and Enhances the Gut Microflora Composition in Rats. ACS Biomaterials Science and Engineering, 11(3), 1646-1659.
DOI Scopus3 WoS3 Europe PMC1
2025 Yin, B., Yang, M., Wang, B., Zhang, Y., Li, N., Li, Q., . . . Zhai, Y. (2025). Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats. Frontiers in Pharmacology, 16, 14 pages.
DOI Scopus1 WoS1 Europe PMC1
2025 Xuan, Y. Y., Li, L., Wu, Y., Wei, Z. L., Zhang, M., Liu, M. N., . . . Chen, K. M. (2025). Pinoresinol diglucoside alleviates hindlimb unloading-induced bone loss in mice. Life Sciences in Space Research.
DOI
2023 Zhou, J., Ren, X. M., Wang, X., Li, Z., & J Xian, C. (2023). Recent advances and challenges of the use of the CRISPR/Cas system as a non-nucleic acid molecular diagnostic. Heliyon, 9(12), 17 pages.
DOI Scopus9 WoS9 Europe PMC4
2023 Ciavarella, D., Lorusso, M., Fanelli, C., Cazzolla, A. P., Maci, M., Ferrara, D., . . . Minervini, G. (2023). The Correlation between Mandibular Arch Shape and Vertical Skeletal Pattern. MEDICINA-LITHUANIA, 59(11), 12 pages.
DOI WoS5
2023 Liu, J., Leng, F. F., Gao, Y. H., He, W. F., Wang, J. F., Xian, C. J., . . . Chen, K. M. (2023). Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity. Journal of Cellular and Molecular Medicine, 27(1), 36-51.
DOI Scopus11 WoS6 Europe PMC5
2023 Miao, L. W., Liu, T. Z., Sun, Y. H., Cai, N., Xuan, Y. Y., Wei, Z., . . . Chen, K. M. (2023). Simulated microgravity-induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia. Journal of Cellular Physiology, 238(11), 2692-2709.
DOI Scopus17 WoS14 Europe PMC13
2023 Su, Y. W., Lee, A. M. C., Xu, X., Hua, B., Tapp, H., Wen, X. S., & Xian, C. J. (2023). Methotrexate Chemotherapy Causes Growth Impairments, Vitamin D Deficiency, Bone Loss, and Altered Intestinal Metabolism—Effects of Calcitriol Supplementation. Cancers, 15(17), 20 pages.
DOI Scopus7 WoS7 Europe PMC7
2023 Jiang, T., Su, W., Li, Y., Jiang, M., Zhang, Y., Xian, C. J., & Zhai, Y. (2023). Research Progress on Nanomaterials for Tissue Engineering in Oral Diseases. Journal of Functional Biomaterials, 14(8), 28 pages.
DOI Scopus7 WoS4 Europe PMC2
2022 Peymanfar, Y., Su, Y. W., & Xian, C. J. (2022). Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity. Cells, 11(9), 21 pages.
DOI Scopus8 WoS8 Europe PMC6
2022 He, W. F., Qin, R., Gao, Y. H., Zhou, J., Wei, J. J., Liu, J., . . . Chen, K. M. (2022). The interdependent relationship between the nitric oxide signaling pathway and primary cilia in pulse electromagnetic field-stimulated osteoblastic differentiation. FASEB Journal, 36(6), 16 pages.
DOI Scopus14 WoS11 Europe PMC9
2022 Hassanshahi, M., Su, Y. -W., Khabbazi, S., Fan, C. -M., Tang, Q., Wen, X., . . . Xian, C. J. (2022). Icariin attenuates methotrexate chemotherapy-induced bone marrow microvascular damage and bone loss in rats (Retraction of pg 16549, 2019). JOURNAL OF CELLULAR PHYSIOLOGY, 237(5), 2604.
DOI
2022 Patil, S., Hu, L., Zhu, C., Xian, C. J., & Qian, A. (2022). Editorial: Development, metabolism, senescence and mechanotransduction of bone. Frontiers in Cell and Developmental Biology, 10(1103581), 3 pages.
DOI
2022 Zhang, Y., Liu, L., Pillman, K. A., Hayball, J., Su, Y. W., & Xian, C. J. (2022). Differentially expressed miRNAs in bone after methotrexate treatment. Journal of Cellular Physiology, 237(1), 965-982.
DOI Scopus4 WoS6 Europe PMC6
2022 Peymanfar, Y., Su, Y. W., Hassanshahi, M., & Xian, C. J. (2022). Methotrexate treatment suppresses osteoblastic differentiation by inducing Notch2 signaling and blockade of Notch2 rescues osteogenesis by preserving Wnt/β-catenin signaling. Journal of Orthopaedic Research, 40(10), 2258-2270.
DOI Scopus5 WoS6 Europe PMC4
2022 Peymanfar, Y., Su, Y. W., Hassanshahi, M., & Xian, C. J. (2022). Therapeutic Targeting Notch2 Protects Bone Micro-Vasculatures from Methotrexate Chemotherapy-Induced Adverse Effects in Rats. Cells, 11(15), 2382-1-2382-21.
DOI Scopus1 Europe PMC1
2021 Zhang, Y. -L., Liu, L., Su, Y. -W., & Xian, C. J. (2021). miR-6315 Attenuates Methotrexate Treatment-Induced Decreased Osteogenesis and Increased Adipogenesis Potentially through Modulating TGF-β/Smad2 Signalling. Biomedicines, 9(12), 1-20.
DOI Scopus5 WoS6 Europe PMC5
2021 Zhang, Y. -L., Liu, L., Su, Y. -W., & Xian, C. J. (2021). miR-542-3p Attenuates Bone Loss and Marrow Adiposity Following Methotrexate Treatment by Targeting sFRP-1 and Smurf2. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 1-19.
DOI Scopus9 WoS9 Europe PMC7
2021 Mellati, A., Fan, C. M., Tamayol, A., Annabi, N., Dai, S., Bi, J., . . . Zhang, H. (2021). Erratum to: Microengineered 3D cell-laden thermoresponsive hydrogels for mimicking cell morphology and orientation in cartilage tissue engineering: Microengineered 3D Cell-Laden Thermoresponsive Hydrogels (Biotechnology and Bioengineering, (2017), 114, 1, (217-231), 10.1002/bit.26061). Biotechnology and Bioengineering, 118(11), 4530.
DOI
2021 Jiang, H., Zhong, J., Li, W., Dong, J., Xian, C. J., Shen, Y. K., . . . Wang, L. (2021). Gentiopicroside promotes the osteogenesis of bone mesenchymal stem cells by modulation of β-catenin-BMP2 signalling pathway. Journal of Cellular and Molecular Medicine, 25(23), 10825-10836.
DOI Scopus19 WoS17 Europe PMC14
2021 Su, Y. -W., Wong, D. S. K., Fan, J., Chung, R., Wang, L., Chen, Y., . . . Xian, C. J. (2021). Enhanced BMP signalling causes growth plate cartilage dysrepair in rats. Bone, 145, 115874-1-115874-13.
DOI Scopus14 WoS12 Europe PMC12
2021 Zhou, J., Gao, Y. H., Zhu, B. Y., He, W. F., Wang, G., Xian, C. J., & Chen, K. M. (2021). The frequency window effect of sinusoidal electromagnetic fields in promoting osteogenic differentiation and bone formation involves extension of osteoblastic primary cilia and activation of protein kinase A. Cell Biology International, 45(8), 1685-1697.
DOI Scopus8 WoS6 Europe PMC4
2021 Zhang, Y. -L., Liu, L., Peymanfar, Y., Anderson, P., & Xian, C. J. (2021). Roles of microRNAs in osteogenesis or adipogenesis differentiation of bone marrow stromal progenitor cells. International Journal of Molecular Sciences, 22(13), 18 pages.
DOI Scopus28 WoS34 Europe PMC24
2021 Fan, J., Su, Y. -W., Hassanshahi, M., Fan, C. -M., Peymanfar, Y., Piergentili, A., . . . Xian, C. J. (2021). β-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats. Journal of Cellular Physiology, 236(5), 3740-3751.
DOI Scopus6 WoS5 Europe PMC4
2021 Su, Y. -W., Fan, J., Fan, C. -M., Peymanfar, Y., Zhang, Y. -L., & Xian, C. J. (2021). Roles of apoptotic chondrocyte-derived CXCL12 in the enhanced chondroclast recruitment following methotrexate and/or dexamethasone treatment. Journal of Cellular Physiology, 236(8), 5966-5979.
DOI Scopus4 WoS4 Europe PMC4
2021 Tang, Q., Su, Y. -W., Fan, C. -M., Chung, R., Hassanshahi, M., Peymanfar, Y., & Xian, C. J. (2021). Release of CXCL12 From Apoptotic Skeletal Cells Contributes to Bone Growth Defects Following Dexamethasone Therapy in Rats (Retraction of Vol 34, Pg 310, 2019). JOURNAL OF BONE AND MINERAL RESEARCH, 36(11), 2283.
DOI
2021 Wei, L., Wen, X. S., & Xian, C. J. (2021). Chemotherapy-induced intestinal microbiota dysbiosis impairs mucosal homeostasis by modulating toll-like receptor signaling pathways. International Journal of Molecular Sciences, 22(17), 17 pages.
DOI Scopus104 WoS94 Europe PMC79
2020 Lan, H., Huang, T., Xiao, J., Liao, Z., Ouyang, J., Dong, J., . . . Liao, H. (2020). The immuno-reactivity of polypseudorotaxane functionalized magnetic CDMNP-PEG-CD nanoparticles. Journal of Cellular and Molecular Medicine, 25(1), 561-574.
DOI Scopus13 WoS10 Europe PMC11
2020 Dong, J., Jhu, R. J., Wang, L., Jiang, C. P., & Xian, C. J. (2020). A hybrid platform for three-dimensional printing of bone scaffold by combining thermal-extrusion and electrospinning methods. Microsystem Technologies, 26(6), 1847-1860.
DOI Scopus9 WoS8
2020 Che, H., Li, J., Li, Y., Ma, C., Liu, H., Qin, J., . . . Ren, Y. (2020). p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. Elife, 9(e52570), 1-23.
DOI Scopus163 WoS160 Europe PMC133
2020 Tang, Q., Su, Y., Fan, C., Chung, R., Hassanshahi, M., Peymanfar, Y., & Xian, C. (2020). Erratum to: Release of CXCL12 From Apoptotic Skeletal Cells Contributes to Bone Growth Defects Following Dexamethasone Therapy in Rats: CHEMOKINE CXCL12 IN DEX THERAPY-INDUCED BONE GROWTH DEFECTS (Journal of Bone and Mineral Research, (2019), 34, 2, (310-326), 10.1002/jbmr.3597). Journal of Bone and Mineral Research, 35(8), 1612-1613.
DOI Scopus2 WoS1 Europe PMC1
2020 Wong, R. H., Zaw, J. J. T., Xian, C. J., & Howe, P. R. (2020). Regular supplementation with resveratrol improves bone mineral density in postmenopausal women: a randomised, placebo-controlled trial. Journal of Bone and Mineral Research, 35(11), 2121-2131.
DOI Scopus118 WoS109 Europe PMC92
2020 Zhang, Q., Li, J., Li, Y., Che, H., Chen, Y., Dong, J., . . . Ren, Y. (2020). Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment. Journal of Cellular and Molecular Medicine, 24(16), 8950-8961.
DOI Scopus23 WoS21 Europe PMC18
2019 Hassanshahi, M., Hassanshahi, A., Khabbazi, S., Su, Y. W., & Xian, C. J. (2019). Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow. Critical Reviews in Oncology/Hematology, 137, 43-56.
DOI Scopus21 WoS18 Europe PMC16
2019 Zhou, J., Gao, Y. H., Zhu, B. Y., Shao, J. L., Ma, H. P., Xian, C. J., & Chen, K. M. (2019). Sinusoidal electromagnetic fields increase peak bone mass in rats by activating Wnt10b/β-catenin in primary cilia of osteoblasts. Journal of Bone and Mineral Research, 34(7), 1336-1351.
DOI Scopus42 WoS36 Europe PMC29
2019 Zhang, X., Zhang, Y., Fan, J., Yuan, F., Tang, Q., & Xian, C. J. (2019). Analyses of fracture line distribution in intra-articular distal radius fractures. Radiologia Medica, 124(7), 613-619.
DOI Scopus22 WoS20 Europe PMC21
2019 Wang, L., Dong, J., & Xian, C. J. (2019). Computational modeling of bone cells and their biomechanical behaviors in responses to mechanical stimuli. Critical reviews in eukaryotic gene expression, 29(1), 51-67.
DOI Scopus5 WoS5 Europe PMC1
2019 Luo, P., Dong, J., Qi, J., Zhang, Y., Liu, X., Zhong, Y., . . . Wang, L. (2019). An enhanced staining method K-B-2R staining for three-dimensional nerve reconstruction. BMC Neuroscience, 20(1), 32.
DOI Scopus1 WoS1 Europe PMC1
2019 Hu, J., Shi, D., Ding, M., Huang, T., Gu, R., Xiao, J., . . . Liao, H. (2019). Calmodulin-dependent signalling pathways are activated and mediate the acute inflammatory response of injured skeletal muscle. The Journal of Physiology, 597(21), 5161-5177.
DOI Scopus19 WoS21 Europe PMC17
2019 Liu, X., Cui, H., Niu, H., Wang, L., Li, X., Sun, J., . . . Xian, C. J. (2019). Hydrocortisone suppresses early paraneoplastic inflammation and angiogenesis to attenuate early hepatocellular carcinoma progression in rats. OncoTargets and therapy, 12, 9481-9493.
DOI Scopus11 WoS8 Europe PMC9
2019 Hassanshahi, M., Khabbazi, S., Peymanfar, Y., Hassanshahi, A., Hosseini-Khah, Z., Su, Y. W., & Xian, C. J. (2019). Critical limb ischemia: current and novel therapeutic strategies. Journal of Cellular Physiology, 234(9), 14445-14459.
DOI Scopus24 WoS21 Europe PMC17
2019 Khabbazi, S., Hassanshahi, M., Hassanshahi, A., Peymanfar, Y., Su, Y. W., & Xian, C. J. (2019). Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression. Naunyn-Schmiedeberg's Archives of Pharmacology, 392(2), 123-133.
DOI Scopus18 WoS20 Europe PMC16
2019 Hassanshahi, M., Su, Y. W., Khabbazi, S., Fan, C. M., Tang, Q., Wen, X., . . . Xian, C. J. (2019). Icariin attenuates methotrexate chemotherapy-induced bone marrow microvascular damage and bone loss in rats. Journal of Cellular Physiology, 234(9), 16549-16561.
DOI Scopus7 WoS8 Europe PMC3
2019 Chen, C., Dong, J., Chen, H., Wang, X., Mei, J., Wang, L., & Xian, C. J. (2019). Preparation of adriamycin gelatin microsphere-loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells. Journal of Cellular Physiology, 234(7), 10771-10781.
DOI Scopus14 WoS13 Europe PMC10
2019 Hassanshahi, A., Hassanshahi, M., Khabbazi, S., Hosseini-Khah, Z., Peymanfar, Y., Ghalamkari, S., . . . Xian, C. J. (2019). Adipose-derived stem cells for wound healing. Journal of Cellular Physiology, 234(6), 7903-7914.
DOI Scopus177 WoS157 Europe PMC129
2019 Hassanshahi, M., Su, Y. W., Khabbazi, S., Fan, C. M., Chen, K. M., Wang, J. F., . . . Xian, C. J. (2019). Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats. Journal of Cellular Physiology, 234(7), 11276-11286.
DOI Scopus12 WoS12 Europe PMC7
2019 Wang, Y. Y., Pu, X. Y., Shi, W. G., Fang, Q. Q., Chen, X. R., Xi, H. R., . . . Chen, K. M. (2019). Pulsed electromagnetic fields promote bone formation by activating the sAC–cAMP–PKA–CREB signaling pathway. Journal of Cellular Physiology, 234(3), 2807-2821.
DOI Scopus46 WoS32 Europe PMC26
2019 Hassanshahi, M., Su, Y. W., Fan, C. M., Khabbazi, S., Hassanshahi, A., & Xian, C. J. (2019). Methotrexate chemotherapy–induced damages in bone marrow sinusoids: an in vivo and in vitro study. Journal of Cellular Biochemistry, 120(3), 3220-3231.
DOI Scopus14 WoS15
2019 Lee, A., Bowen, J., Su, Y., Plews, E., Chung, R., Keefe, D. M., & Xian, C. (2019). Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats. Journal of Cellular Biochemistry, 120(3), 4180-4191.
DOI Scopus5 WoS5 Europe PMC6
2019 Tang, Q., Su, Y. W., & Xian, C. J. (2019). Determining Oxidative Damage by Lipid Peroxidation Assay in Rat Serum. Bio Protocol, 9(12), 5 pages.
DOI Scopus40 WoS34
2019 Feng., Qiu, H., Zhang, H., Chen, Y., Wang, H., Cai, D., & Xian, C. J. (2019). Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates posttraumatic osteoarthritis (vol 233, pg 6135, 2018). JOURNAL OF CELLULAR PHYSIOLOGY, 234(6), 9873.
DOI
2019 Tang, Q., Su, Y. W., Fan, C. M., Chung, R., Hassanshahi, M., Peymanfar, Y., & Xian, C. J. (2019). Release of CXCL12 from apoptotic skeletal cells contributes to bone growth defects following dexamethasone therapy in rats. Journal of Bone and Mineral Research, 34(2), 310-326.
DOI Scopus6 WoS6 Europe PMC5
2019 Huang, L., Lin, H., Kang, L., Huang, P., Huang, J., Cai, J., . . . Dong, J. (2019). Aberrant expression of long noncoding RNA SNHG15 correlates with liver metastasis and poor survival in colorectal cancer. Journal of Cellular Physiology, 234(5), 7032-7039.
DOI Scopus49 WoS52 Europe PMC46
2019 Cai, J., Huang, L., Huang, J., Kang, L., Lin, H., Huang, P., . . . Xian, C. J. (2019). Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer. Journal of Cellular Biochemistry, 120(4), 4935-4941.
DOI Scopus23 WoS17 Europe PMC17
2018 Guo, Y., Wang, L. -P., Li, C., Xiong, Y. -X., Yan, Y. -T., Zhao, L. -Q., . . . Xian, C. J. (2018). Effects of ginsenoside Rb1 on expressions of phosphorylation Akt/phosphorylation mTOR/phosphorylation PTEN in artificial abnormal hippocampal microenvironment in rats. Neurochemical Research, 43(10), 1927-1937.
DOI Scopus22 WoS18 Europe PMC15
2018 Yan, B., Huang, M., Zeng, C., Yao, N., Zhang, J., Yan, B., . . . Wang, L. (2018). Locally produced IGF-1 promotes hypertrophy of the ligamentum flavum via the mTORC1 signaling pathway. Cellular physiology and biochemistry, 48(1), 293-303.
DOI Scopus15 WoS16 Europe PMC13
2018 Qin, T., Huang, D., Liu, Z., Zhang, X., Jia, Y., Xian, C. J., & Li, K. (2018). Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor-C in a mouse model of lung cancer. Cancer Science, 109(8), 2469-2478.
DOI Scopus18 WoS17 Europe PMC16
2018 Lv, C., Shi, C., Li, L., Wen, X., & Xian, C. J. (2018). Chinese herbal medicines in the prevention and treatment of chemotherapy-induced nausea and vomiting. Current Opinion in Supportive and Palliative Care, 12(2), 174-180.
DOI Scopus22 WoS20 Europe PMC17
2018 Wang, L., Dong, J., & Xian, C. J. (2018). Computational investigation on the biomechanical responses of the osteocytes to the compressive stimulus: a poroelastic model. BioMed Research International, 2018(article no. 4071356), 4071356-1-4071356-16.
DOI Scopus18 WoS13 Europe PMC5
2018 Wang, S., Li, J., Tian, J., Yu, Z., Gao, K., Shao, J., . . . Xian, C. J. (2018). High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF-κB p65 pathway. Journal of Cellular Physiology, 233(9), 7206-7216.
DOI Scopus23 WoS20 Europe PMC22
2018 Yin, C., Zhang, Y., Hu, L., Tian, Y., Chen, Z., Li, D., . . . Xian, C. J. (2018). Cover Image, Volume 233, Number 7, July 2018.. Journal of cellular physiology, 233(7), i.
DOI
2018 Wei, G., Wang, L., Dong, D., Teng, Z., Shi, Z., Wang, K., . . . Xian, C. J. (2018). Promotion of cell growth and adhesion of a peptide hydrogel scaffold via mTOR/cadherin signaling. Journal of Cellular Physiology, 233(2), 822-829.
DOI Scopus11 WoS10 Europe PMC8
2018 Su, Y., Zhou, X., Foster, B., Grills, B., Xu, J., & Xian, C. (2018). Roles of neurotrophins in skeletal tissue formation and healing. Journal of Cellular Physiology, 233(3), 2133-2145.
DOI Scopus63 WoS54 Europe PMC48
2018 Hu, L., Su, P., Yin, C., Zhang, Y., Li, R., Yan, K., . . . Xian, C. (2018). Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis. Journal of Cellular Physiology, 233(2), 1574-1584.
DOI Scopus52 WoS46 Europe PMC39
2018 Jiang, H., Chen, Y., Chen, G., Tian, X., Tang, J., Luo, L., . . . Xian, C. (2018). Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling. Journal of Cellular Physiology, 233(2), 1017-1028.
DOI Scopus47 WoS44 Europe PMC38
2018 Zhang, Y., Yin, C., Hu, L., Chen, Z., Zhao, F., Li, D., . . . Xian, C. J. (2018). MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation. Human gene therapy, 29(2), 259-270.
DOI Scopus23 WoS23 Europe PMC20
2018 Lin, C., Shao, Y., Zeng, C., Zhao, C., Fang, H., Wang, L., . . . Xian, C. J. (2018). Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis. Journal of Cellular Physiology, 233(8), 6135-6147.
DOI Scopus90 WoS82 Europe PMC66
2018 Zhu, B. Y., Yang, Z. D., Chen, X. R., Zhou, J., Gao, Y. H., Xian, C. J., & Chen, K. M. (2018). Exposure duration is a determinant of the effect of sinusoidal electromagnetic fields on peak bone mass of young rats. Calcified Tissue International, 103(1), 95-106.
DOI Scopus9 WoS7 Europe PMC2
2018 Li, W. -Y., Li, X. -Y., Tian, Y. -H., Chen, X. -R., Zhou, J., Zhu, B. -Y., . . . Chen, K. -M. (2018). Pulsed electromagnetic fields prevented the decrease of bone formation in hindlimb-suspended rats by activating sAC/cAMP/PKA/CREB signaling pathway. Bioelectromagnetics, 39(8), 569-584.
DOI Scopus18 WoS14 Europe PMC8
2018 Fan, C., Su, Y., Howe, P., & Xian, C. (2018). Long chain omega-3 polyunsaturated fatty acid supplementation protects against adriamycin and cyclophosphamide chemotherapy-induced bone marrow damage in female rats. International Journal of Molecular Sciences, 19(2), 484-1-484-15.
DOI Scopus10 WoS8 Europe PMC9
2018 Zhang, X., Zhu, Y., Zhang, C., Liu, J., Sun, T., Li, D., . . . Teng, Z. (2018). miR-542-3p prevents ovariectomy-induced osteoporosis in rats via targeting SFRP1. Journal of Cellular Physiology, 233(9), 6798-6806.
DOI Scopus54 WoS54 Europe PMC44
2018 Yin, C., Zhang, Y., Hu, L., Tian, Y., Chen, Z., Li, D., . . . Xian, C. J. (2018). Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation. Journal of Cellular Physiology, 233(7), 5405-5419.
DOI Scopus46 WoS42 Europe PMC37
2018 Teng, Z., Xie, X., Zhu, Y., Liu, J., Hu, X., Na, Q., . . . Xian, C. J. (2018). miR-142-5p in bone marrow-derived Mesenchymal stem cells promotes osteoporosis involving targeting adhesion molecule VCAM-1 and inhibiting cell migration. BioMed Research International, 2018, 3274641-1-3274641-7.
DOI Scopus18 WoS18 Europe PMC12
2018 Sun, J., Cui, H., Gao, Y., Pan, Y., Zhou, K., Huang, J., . . . Xian, C. J. (2018). TGF- α overexpression in breast cancer bone metastasis and primary lesions and TGF- α enhancement of expression of procancer metastasis cytokines in bone marrow mesenchymal stem cells. BioMed Research International, 2018(6565393), 6565393-1-6565393-10.
DOI Scopus20 WoS17 Europe PMC13
2018 Zhai, Y., Wang, Q., Li, Y., Cui, J., Feng, K., Kong, X., & Xian, C. J. (2018). The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K/Akt axis. Biomedicine and Pharmacotherapy, 102, 1015-1024.
DOI Scopus35 WoS34 Europe PMC26
2018 Jiang, Z., Derrick-Roberts, A., Jackson, M., Rossouw, C., Pyragius, C., Xian, C., . . . Byers, S. (2018). Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice. Molecular Genetics and Metabolism, 124(2), 135-142.
DOI Scopus13 WoS12 Europe PMC13
2018 Xi, H. R., Ma, H. P., Yang, F. F., Gao, Y. H., Zhou, J., Wang, Y. Y., . . . Chen, K. M. (2018). Total flavonoid extract of Epimedium herb increases the peak bone mass of young rats involving enhanced activation of the AC10/cAMP/PKA/CREB pathway. Journal of Ethnopharmacology, 223, 76-87.
DOI Scopus28 WoS27 Europe PMC24
2018 Su, Y. W., Chim, S. M., Zhou, L., Hassanshahi, M., Chung, R., Fan, C., . . . Xian, C. J. (2018). Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats. Bone, 116, 232-247.
DOI Scopus18 WoS16 Europe PMC13
2017 Hassanshahi, M., Hassanshahi, A., Khabbazi, S., Su, Y., & Xian, C. (2017). Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy. Angiogenesis, 20(4), 427-442.
DOI Scopus43 WoS43 Europe PMC37
2017 Fan, J., Mei, J., Zhang, M. Z., Yuan, F., Li, S. Z., Yu, G. R., . . . Xian, C. J. (2017). Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma. Oncology Letters, 14(2), 2439-2445.
DOI Scopus14 WoS13 Europe PMC14
2017 Kaisang, L., Siyu, W., Lijun, F., Daoyan, P., Xian, C. J., & Jie, S. (2017). Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing. Journal of Surgical Research, 217, 63-74.
DOI Scopus95 WoS96 Europe PMC73
2017 Shi, W., Xie, Y., He, J., Zhou, J., Gao, Y., Wei, W., . . . Wang, J. (2017). Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia. Scientific Reports, 7(1866), 1866-1-1866-12.
DOI Scopus55 WoS47 Europe PMC35
2017 Fan, J., Yuan, F., Li, S. Z., Tang, Q., & Xian, C. J. (2017). Is the preoperative closed reduction irreplaceable for distal radius fracture surgical treatment? - a retrospective clinical study. International journal of clinical and experimental medicine, 10(1), 1309-1314.
Scopus3 WoS2
2017 Chen, X., Chen, W., Lu, Z., Zhang, Y., Chang, R., Hassan, M. M., . . . Xiang, Y. (2017). MBSA: a lightweight and flexible storage architecture for virtual machines. CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE, 29(16), 10 pages.
DOI WoS2
2017 Shi, W., Gao, Y., Wang, Y., Zhou, J., Wei, Z., Ma, X., . . . Chen, K. (2017). The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts. Journal of Biological Chemistry, 292(51), 20883-20896.
DOI Scopus65 WoS58 Europe PMC43
2017 Lee, A., Shandala, T., Soo, P., Su, Y., King, T., Chen, K., . . . Xian, C. (2017). Effects of resveratrol supplementation on methotrexate chemotherapy-induced bone loss. Nutrients, 9(3), 255-1-255-15.
DOI Scopus28 WoS20 Europe PMC14
2017 Ma, X. N., Ma, C. X., Shi, W. G., Zhou, J., Ma, H. P., Gao, Y. H., . . . Chen, K. M. (2017). Primary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro. Journal of Endocrinological Investigation, 40(4), 357-366.
DOI Scopus9 WoS8 Europe PMC6
2017 Bin, X., Lin, C., Huang, X., Zhou, Q., Wang, L., & Xian, C. J. (2017). FGF-2 gene polymorphism in osteoporosis among Guangxi’s Zhuang Chinese. International Journal of Molecular Sciences, 18(7), 1358-1-1358-13.
DOI Scopus7 WoS6 Europe PMC4
2017 Su, Y., Chen, K., Hassanshahi, M., Tang, Q., Howe, P., & Xian, C. (2017). Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals. Annals of the New York Academy of Sciences, 1403(1), 109-117.
DOI Scopus19 WoS16 Europe PMC13
2017 Fan, C., Georgiou, K., Morris, H., McKinnon, R., Keefe, D., Howe, P., & Xian, C. (2017). Combination breast cancer chemotherapy with doxorubicin and cyclophosphamide damages bone and bone marrow in a female rat model. Breast Cancer Research and Treatment, 165(1), 41-51.
DOI Scopus41 WoS39 Europe PMC36
2017 Mellati, A., Fan, C., Tamayol, A., Annabi, N., Dai, S., Bi, J., . . . Zhang, H. (2017). Microengineered 3D cell-laden thermoresponsive hydrogels for mimicking cell morphology and orientation in cartilage tissue engineering. Biotechnology and Bioengineering, 114(1), 217-231.
DOI Scopus79 WoS70 Europe PMC50
2017 Xie, Y., Yi, L., Weng, T., Huang, J., Luo, F., Jiang, W., . . . Chen, L. (2017). Fibroblast growth factor receptor 3 deficiency does not impair the osteoanabolic action of parathyroid hormone on mice. International Journal of Biological Sciences, 12(8), 990-999.
DOI Scopus7 WoS5 Europe PMC7
2016 Wang, G., Wang, J., Sun, D., Xin, J., Wang, L., Huang, D., . . . Xian, C. J. (2016). Short-term hypoxia accelerates bone loss in ovariectomized rats by suppressing osteoblastogenesis but enhancing osteoclastogenesis. Medical Science Monitor, 22, 2961-2971.
DOI Scopus31 WoS31 Europe PMC28
2016 Hao, J., Gu, F., Zhu, J., Lu, S., Liu, Y., Li, Y., . . . Xian, C. J. (2016). Low night temperature affects the phloem ultrastructure of lateral branches and raffinose family oligosaccharide (RFO) accumulation in RFO-transporting plant melon (Cucumismelo L.) during fruit expansion. PLoS ONE, 11(8), e0160909-1-e0160909-15.
DOI Scopus23 WoS20 Europe PMC10
2016 Cui, H., Li, T., Wang, L., Su, Y., & Xian, C. J. (2016). Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice. Scientific Reports, 6(1), 19185-1-19185-9.
DOI Scopus57 WoS56 Europe PMC38
2016 Su, Y. W., Chung, R., Ruan, C. S., Chim, S. M., Kuek, V., Dwivedi, P. P., . . . Xian, C. J. (2016). Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats. Journal of Bone and Mineral Research, 31(6), 1258-1274.
DOI Scopus74 WoS64 Europe PMC57
2016 Zhou, J., Ma, X., Gao, Y., Yan, J., Shi, W., Xian, C., & Chen, K. (2016). Sinusoidal electromagnetic fields promote bone formation and inhibit bone resorption in rat femoral tissues in vitro. Electromagnetic Biology and Medicine, 35(1), 75-83.
DOI Scopus16 WoS13 Europe PMC12
2016 Xie, Y., Shi, W., Zhou, J., Gao, Y., Li, S., Fang, Q., . . . Chen, K. (2016). Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium. Bone, 93, 22-32.
DOI Scopus75 WoS63 Europe PMC45
2016 Wang, L., & Xian, C. J. (2016). Dynamic analyses of osteoblast vibrational responses: a finite element viscoelastic model. Journal of Vibroengineering, 18(7), 4605-4616.
DOI Scopus6 WoS5
2016 Wang, L., Hsu, H. -Y., Li, X., & Xian, C. J. (2016). Effects of frequency and acceleration amplitude on osteoblast mechanical vibration responses: a finite element study. BioMed Research International, 2016(2735091), 2735091-1-2735091-16.
DOI Scopus23 WoS13 Europe PMC10
2016 Cai, Z., Li, Z., Wang, L., Hsu, H., Xiao, Z., & Xian, C. J. (2016). A three-dimensional finite element modelling of human chest injury following front or side impact loading. Journal of Vibroengineering, 18(1), 539-550.
Scopus13 WoS9
2016 Yang, L., Wang, L., Wang, X., Xian, C. J., & Lu, H. (2016). A possible role of intestinal microbiota in the pathogenesis of ankylosing spondylitis. International Journal of Molecular Sciences, 17(12), 2126-1-2126-17.
DOI Scopus56 WoS50 Europe PMC42
2016 Cai, Z., Li, Z., Dong, J., Mao, Z., Wang, L., & Xian, C. J. (2016). A study on protective performance of bullet-proof helmet under impact loading. Journal of Vibroengineering, 18(4), 2495-2507.
DOI Scopus19 WoS11
2016 Shi, C. -J., Wen, X. -S., Gao, H. -F., Liu, Z. -H., Xu, X. -K., Li, L. -F., . . . Xian, C. J. (2016). Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats. Journal of Ethnopharmacology, 183, 143-150.
DOI Scopus27 WoS23 Europe PMC20
2015 Gao, H., Wen, X., & Xian, C. (2015). Hydroxymethyl furfural in Chinese herbal medicines: Its formation, presence, metabolism, bioactivities and implications. African Journal of Traditional, Complementary and Alternative Medicines, 12(2), 43-54.
DOI Scopus18 WoS13
2015 Wang, L., Dong, J., & Xian, C. J. (2015). Strain amplification analysis of an osteocyte under static and cyclic loading: a finite element study. BioMed Research International, 2015(376474), 376474-1-376474-14.
DOI Scopus34 WoS38 Europe PMC15
2015 Zhang, L., Ge, S., Liu, H., Wang, Q., Wang, L., & Xian, C. (2015). Contact damage failure analyses of fretting wear behavior of the metal stem titanium alloy-bone cement interface. Journal of the Mechanical Behavior of Biomedical Materials, 51, 132-146.
DOI Scopus14 WoS13 Europe PMC7
2015 King, T., Shandala, T., Lee, A., Foster, B., Chen, K., Howe, P., & Xian, C. (2015). Potential effects of phytoestrogen genistein in modulating acute methotrexate chemotherapy-induced osteoclastogenesis and bone damage in rats. International Journal of Molecular Sciences, 16(8), 18293-18311.
DOI Scopus29 WoS22 Europe PMC16
2015 Zhong, Y., Wang, L., Dong, J., Zhang, Y., Luo, P., Qi, J., . . . Xian, C. J. (2015). Three-dimensional reconstruction of peripheral nerve internal fascicular groups. Scientific Reports, 5(1), 17168-1-17168-13.
DOI Scopus30 WoS25 Europe PMC18
2015 Zhou, J., Chen, K., Zhi, D., Xie, Q., Xian, C., & Li, H. (2015). Effects of pyrite bioleaching solution of Acidithiobacillus ferrooxidans on viability, differentiation and mineralization potentials of rat osteoblasts. Archives of Pharmacal Research, 38(12), 2228-2240.
DOI Scopus8 WoS8 Europe PMC5
2015 Cui, H., Yang, M., Wang, L., & Xian, C. J. (2015). Identification of a new marine bacterial strain SD8 and optimization of its culture conditions for producing alkaline protease. PLoS ONE, 10(12), e0146067-1-e0146067-13.
DOI Scopus19 WoS11 Europe PMC10
2015 Fan, C., Georgiou, K. R., McKinnon, R. A., Keefe, D. M. K., Howe, P. R. C., & Xian, C. J. (2015). Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats. Journal of Bone and Mineral Metabolism, 34(3), 277-290.
DOI Scopus31 WoS30 Europe PMC27
2015 Yan, J., Zhou, J., Ma, H., Ma, X., Gao, Y., Shi, W., . . . Chen, K. (2015). Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia. Molecular and Cellular Endocrinology, 404(C), 132-140.
DOI Scopus63 WoS54 Europe PMC43
2015 Georgiou, K., Nadhanan, R., Fan, C., & Xian, C. (2015). Methotrexate-induced bone marrow adiposity Is mitigated by folinic acid supplementation through the regulation of Wnt/β-catenin signalling. Journal of Cellular Physiology, 230(3), 648-656.
DOI Scopus19 WoS17 Europe PMC12
2015 Zhou, F., Yu, Y., Zhou, X., & Xian, C. (2015). Methotrexate chemotherapy triggers touch-evoked pain and increased CGRP-positive sensory fibres in the tibial periosteum of young rats. Bone, 73, 24-31.
DOI Scopus5 WoS5 Europe PMC2
2015 Chim, S., Kuek, V., Chow, S., Lim, B., Tickner, J., Zhao, J., . . . Xu, J. (2015). EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades. Journal of Cellular Physiology, 230(1), 82-94.
DOI Scopus46 WoS48 Europe PMC41
2014 Zhai, Y., Guo, X., Ge, B., Zhen, P., Ma, X., Zhou, J., . . . Chen, K. (2014). Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG. Bone, 66, 189-198.
DOI Scopus117 WoS107 Europe PMC85
2014 Zhou, J., Wang, J., Ge, B., Ma, X., Ma, H., Xian, C., & Chen, K. (2014). Different electromagnetic field waveforms have different effects on proliferation, differentiation and mineralization of osteoblasts in vitro. Bioelectromagnetics, 35(1), 30-40.
DOI Scopus39 WoS34 Europe PMC29
2014 Lee, A., Shandala, T., Nguyen, L., Muhlhausler, B., Chen, K., Howe, P., & Xian, C. (2014). Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats. Nutrients, 6(12), 5871-5887.
DOI Scopus34 WoS38 Europe PMC31
2014 Xiang, R., Lee, A., Eindorf, T., Javadmanesh, A., Ghanipoor-Samami, M., Gugger, M., . . . Hiendleder, S. (2014). Widespread differential maternal and paternal genome effects on fetal bone phenotype at mid-gestation. Journal of Bone and Mineral Research, 29(11), 2392-2404.
DOI Scopus10 WoS9 Europe PMC9
2014 Lee, A., Morrison, J., Botting, K., Shandala, T., & Xian, C. (2014). Effects of maternal hypoxia during pregnancy on bone development in offspring: a guinea pig model. International Journal of Endocrinology, 2014(article no. 916918), 916918-1-916918-12.
DOI Scopus9 WoS9 Europe PMC9
2014 Raghu Nadhanan, R., Fan, C., Su, Y., Howe, P., & Xian, C. (2014). Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone. Journal of Orthopaedic Research, 32(4), 587-596.
DOI Scopus19 WoS13 Europe PMC10
2014 Ma, H., Ma, X., Ge, B., Zhen, P., Zhou, J., Gao, Y., . . . Chen, K. (2014). Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potential in vitro. Cell Proliferation, 47(6), 527-539.
DOI Scopus74 WoS65 Europe PMC50
2014 Fan, C., Garcia, M., Scherer, M., Tran, C., & Xian, C. (2014). Potential roles of metallothioneins I and II in protecting bone growth following acute methotrexate chemotherapy. Journal of Chemotherapy, 26(1), 37-48.
DOI Scopus1 WoS2 Europe PMC1
2014 Zhai, Y., Pan, Y., Niu, Y., Li, C., Wu, X., Fan, W., . . . Xian, C. (2014). The importance of the prenyl group in the activities of osthole in enhancing bone formation and inhibiting bone resorption in vitro. International Journal of Endocrinology, 2014(article no. 921954), 1-16.
DOI Scopus35 WoS33 Europe PMC24
2014 Chung, R., & Xian, C. (2014). Recent research on the growth plate: mechanisms for growth plate injury repair and potential cell-based therapies for regeneration. Journal of Molecular Endocrinology, 53(1), T45-T61.
DOI Scopus60 WoS42 Europe PMC40
2014 Xian, C. J. (2014). Recent research on the growth plate : regulation, bone growth defects, and potential treatments. Journal of molecular endocrinology, 53(1), 1-2.
DOI Scopus12 WoS8
2014 Chung, R., Foster, B., & Xian, C. (2014). The potential role of VEGF-induced vascularisation in the bony repair of injured growth plate cartilage. Journal of Endocrinology, 221(1), 63-75.
DOI Scopus40 WoS31 Europe PMC28
2014 Xian, C. J. (2014). Recent research on the growth plate: Regulation, bone growth defects, and potential treatments. Journal of molecular endocrinology, 53(1), E1-E2.
DOI Scopus1 Europe PMC9
2014 Zhou, J., Wang, J. Q., Ge, B. F., Ma, X. N., Ma, H. P., Xian, C. J., & Chen, K. M. (2014). Erratum: different electromagnetic field waveforms have different effects on proliferation, differentiation and mineralization of osteoblasts in vitro. Bioelectromagnetics, 35(1), 38-40.
DOI
2013 Ming, L. G., Lv, X., Ma, X. N., Ge, B. F., Zhen, P., Song, P., . . . Chen, K. M. (2013). Erratum: The prenyl group contributes to activities of phytoestrogen 8-prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro (Endocrinology (2013) 154 (1202-1214) DOI: 10.1210/en.2012-2086). Endocrinology, 154(9), 3487.
DOI Scopus1
2013 Su, Y. W., Chung, R., Vincent, C., Chim, S. M., Zhou, F., Lee, A., . . . Xian, C. (2013). Potential roles of neurotrophin-3 in growth plate cartilage bony repair and skeletal cell formation. Journal of bone and mineral research, 28(1), 107.
WoS1
2013 Ma, X., Zhou, J., Ge, B., Zhen, P., Ma, H., Shi, W., . . . Chen, K. (2013). Icariin induces osteoblast differentiation and mineralization without dexamethasone in vitro. Planta Medica, 79(16), 1501-1508.
DOI Scopus37 WoS33 Europe PMC25
2013 Shan, P. F., Xian, C. J., Li, M., Xiang, G. D., & Yuan, L. Q. (2013). Osteoporosis. International Journal of Endocrinology, 2013(952858), 1-2.
DOI Scopus5 Europe PMC2
2013 Ming, L., Lv, X., Ma, X., Ge, B., Zhen, P., Song, P., . . . Chen, K. (2013). The prenyl group contributes to activities of phytoestrogen 8-prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro. Endocrinology, 154(3), 1202-1214.
DOI Scopus51 WoS47 Europe PMC40
2013 Chung, R., Wong, D., Macsai, C., Piergentili, A., Del Bello, F., Quaglia, W., & Xian, C. (2013). Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats. Bone, 52(2), 651-658.
DOI Scopus37 WoS33 Europe PMC28
2013 Ming, L., Chen, K., & Xian, C. (2013). Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. Journal of Cellular Physiology, 228(3), 513-521.
DOI Scopus216 WoS185 Europe PMC142
2013 Ming, L. -G., Lv, X., Ma, X. -N., Ge, B. -F., Zhen, P., Song, P., . . . Chen, K. -M. (2013). The Prenyl Group Contributes to Activities of Phytoestrogen 8-Prenynaringenin in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro (vol 154, pg 1202, 2013). ENDOCRINOLOGY, 154(9), 3487.
DOI
2013 Raghu Nadhanan, R., Skinner, J., Chung, R., Su, Y., Howe, P., & Xian, C. (2013). Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats. PLoS One, 8(8), e71592-1-e71592-12.
DOI Scopus32 WoS28 Europe PMC22
2013 Chung, R., Foster, B., & Xian, C. (2013). Inhibition of protein kinase-D promotes cartilage repair at injured growth plate in rats. Injury-international Journal of the Care of the Injured, 44(7), 914-922.
DOI Scopus15 WoS11 Europe PMC10
2013 Dwivedi, P., Grose, R., Filmus, J., Hii, C., Xian, C., Anderson, P., & Powell, B. (2013). Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3. Bone, 55(2), 367-376.
DOI Scopus45 WoS44 Europe PMC44
2012 Fan, C., Foster, B., Hui, S., & Xian, C. (2012). Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate. PLoS One, 7(10), 1-12.
DOI Scopus48 WoS40 Europe PMC32
2012 Jin, M., Yu, Y., Qi, H., Xie, Y., Su, N., Wang, X., . . . Chen, L. (2012). A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia. Human Molecular Genetics, 21(26), 5443-5455.
DOI Scopus45 WoS43 Europe PMC37
2012 Xie, Y., Su, N., Jin, M., Qi, H., Yang, J., Li, C., . . . Chen, L. (2012). Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia. Human Molecular Genetics, 21(18), 3941-3955.
DOI Scopus41 WoS39 Europe PMC35
2012 Du, X., Xie, Y., Xian, C., & Chen, L. (2012). Role of FGFs/FGFRs in skeletal development and bone regeneration. Journal of Cellular Physiology, 227(12), 3731-3743.
DOI Scopus141 WoS98 Europe PMC113
2012 King, T., Georgiou, K., Cool, J., Scherer, M., Ang, E., Foster, B., . . . Xian, C. (2012). Methotrexate chemotherapy promotes osteoclast formation in the long bone of rats via increased pro-inflammatory cytokines and enhanced NF-κB activation. American Journal of Pathology, 181(1), 121-129.
DOI Scopus57 WoS56 Europe PMC45
2012 Shen, Z., Bi, J., Shi, B., Nguyen, D., Xian, C., Zhang, H., & Dai, S. (2012). Exploring thermal reversible hydrogels for stem cell expansion in three-dimensions. Soft Matter, 8(27), 7250-7257.
DOI Scopus33 WoS31
2012 Raghu Nadhanan, R., Mashtoub, S., Su, Y., Scherer, M., Howarth, G., & Xian, C. (2012). Dietary emu oil supplementation suppresses 5-fluorouracil chemotherapy-induced inflammation, osteoclast formation, and bone loss. American Journal of Physiology-Endocrinology and Metabolism, 302(11), E1440-E1449.
DOI Scopus37 WoS38 Europe PMC29
2012 Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., & Xian, C. (2012). Attenuated Wnt/β-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233.
DOI Scopus63 WoS60 Europe PMC51
2012 Fong, L., Muhlhausler, B., Gibson, R., & Xian, C. (2012). Perinatal maternal dietary supplementation of ω3-fatty acids transiently affects bone marrow microenvironment, osteoblast and osteoclast formation, and bone mass in male offspring. Endocrinology, 153(5), 2455-2465.
DOI Scopus29 WoS28 Europe PMC25
2012 Pyragius, C., Georgiou, K., Foster, B., Zannettino, A., & Xian, C. (2012). Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair. Bone, 50(5), 1081-1091.
DOI Scopus53 WoS48 Europe PMC46
2012 Shandala, T., Ng, Y., Hopwood, B., Yip, Y., Foster, B., & Xian, C. (2012). The role of osteocyte apoptosis in cancer chemotherapy-induced bone loss. Journal of Cellular Physiology, 227(7), 2889-2897.
DOI Scopus49 WoS42 Europe PMC38
2012 Georgiou, K., Scherer, M., King, T., Foster, B., & Xian, C. (2012). Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy-induced damage and recovery of the bone marrow microenvironment. International Journal of Experimental Pathology, 93(2), 104-114.
DOI Scopus20 WoS17 Europe PMC15
2012 Georgiou, K., Scherer, M., Fan, C., Cool, J., King, T., Foster, B., & Xian, C. (2012). Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow. Journal of Cellular Physiology, 227(3), 909-918.
DOI Scopus79 WoS74 Europe PMC69
2012 Georgiou, K. R., Hui, S., & Xian, C. J. (2012). Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy. American journal of stem cells, 1(3), 205-224.
Scopus80 WoS74 Europe PMC64
2012 Hui, S., Sharkey, L., Kidder, L., Zhang, Y., Fairchild, G., Coghill, K., . . . Yee, D. (2012). The influence of therapeutic radiation on the patterns of bone marrow in ovary-intact and ovariectomized mice. PLoS ONE, 7(8), e42668-1-e42668-9.
DOI Scopus28 WoS28 Europe PMC29
2012 Zhou, J., Ming, L. G., Ge, B. F., Wang, J. Q., Zhu, R. Q., Wei, Z., . . . Chen, K. M. (2012). Corrigendum to "Effects of 50Hz sinusoidal electromagnetic fields of different intensities on proliferation, differentiation and mineralization potentials of rat osteoblasts". Bone, 50(3), 812.
DOI
2011 Zhou, J., Ming, L., Ge, B., Wang, J., Zhu, R., Wei, Z., . . . Chen, K. (2011). Effects of 50Hz sinusoidal electromagnetic fields of different intensities on proliferation, differentiation and mineralization potentials of rat osteoblasts. Bone, 49(4), 753-761.
DOI Scopus90 WoS75 Europe PMC67
2011 Ma, H., Ming, L., Ge, B., Zhai, Y., Song, P., Xian, C., & Chen, K. (2011). Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro. Journal of Cellular Biochemistry, 112(3), 916-923.
DOI Scopus150 WoS133 Europe PMC100
2011 Georgiou, K. R., King, T. J., Scherer, M. A., Foster, B. K., & Xian, C. J. (2011). Roles of Wnt/B-catenin signalling in methotrexate chemotherapy-induced bone loss and marrow adiposity. Bone, 48(Supplement 2), 258.
DOI
2011 Chung, R., Foster, B., & Xian, C. (2011). Preclinical studies on mesenchymal stem cell-based therapy for growth plate cartilage injury repair. Stem Cells International, 2011(570125), 1-10.
DOI Scopus32 WoS28 Europe PMC25
2011 Pyragius, C., Hopwood, B., Chung, R., Foster, B., & Xian, C. (2011). Structural and molecular analyses of bone bridge formation within the growth plate injury site and cartilage degeneration at the adjacent uninjured area. Bone, 49(4), 904-912.
DOI Scopus32 WoS30 Europe PMC26
2011 Chung, R., Foster, B., & Xian, C. (2011). Injury responses and repair mechanisms of the injured growth plate. Frontiers in Bioscience (Scholar Edition), 3(3), 117-125.
DOI Scopus35 Europe PMC23
2011 Fan, C., Georgiou, K., King, T., & Xian, C. (2011). Methotrexate toxicity in growing long bones of young rats: A model for studying cancer chemotherapy-induced bone growth defects in children. Journal of Biomedicine and Biotechnology, 2011(903097), 1-8.
DOI Scopus43 WoS35 Europe PMC19
2011 Fan, C., Foster, B., Wallace, W., & Xian, C. (2011). Pathobiology and prevention of cancer chemotherapy-induced bone growth arrest, bone loss, and osteonecrosis. Current Molecular Medicine, 11(2), 140-151.
DOI Scopus37 WoS34 Europe PMC31
2011 Tran, C., Cool, J., & Xian, C. (2011). Dietary zinc and metallothionein on small intestinal disaccharidases activity in mice. World Journal of Gastroenterology, 17(3), 354-360.
DOI Scopus10 WoS9 Europe PMC7
2011 Muhlhausler, B., Miljkovic, D., Fong, L., Xian, C., Duthoit, E., & Gibson, R. (2011). Maternal omega-3 supplementation increases fat mass in male and female rat offspring. Frontiers in Genetics, 2(48), 1-10.
DOI Scopus32 Europe PMC30
2010 McCarty, R., Xian, C., Gronthos, S., Zannettino, A., & Foster, B. (2010). Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury. The Open Orthopaedics Journal, 4(1), 220-226.
DOI Scopus39 Europe PMC45
2010 Georgiou, K., Foster, B., & Xian, C. (2010). Damage and recovery of the bone marrow microenvironment induced by cancer chemotherapy - potential regulatory role of chemokine CXCL12/receptor CXCR4 signalling. Current Molecular Medicine, 10(5), 440-453.
DOI Scopus49 WoS43 Europe PMC40
2009 Gronthos, S., McCarty, R., Mrozik, K., Fitter, S., Paton, S., Menicanin, D., . . . Zannettino, A. (2009). Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: Generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues. Stem Cells and Development, 18(9), 1253-1261.
DOI Scopus74 WoS62 Europe PMC52
2009 Fong, L., Tan, K., Tran, C., Cool, J., Scherer, M., Elovaris, R., . . . Xian, C. (2009). Interaction of dietary zinc and intracellular binding protein metallothionein in postnatal bone growth. Bone, 44(6), 1151-1162.
DOI Scopus52 WoS48 Europe PMC42
2009 Chung, R., Foster, B., Zannettino, A., & Xian, C. (2009). Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate. Bone, 44(5), 878-885.
DOI Scopus64 WoS58 Europe PMC45
2009 Mc Carty, R., Gronthos, S., Zannettino, A., Foster, B., & Xian, C. (2009). Characterisation and Developmental Potential of Ovine Bone Marrow Derived Mesenchymal Stem Cells. Journal of Cellular Physiology, 219(2), 324-333.
DOI Scopus136 WoS119 Europe PMC102
2009 Fan, C., Cool, J., Scherer, M., Foster, B., Shandala, T., Tapp, H., & Xian, C. (2009). Damaging effects of chronic low-dose methotrexate usage on primary bone formation in young rats and potential protective effects of folinic acid supplementary treatment. Bone, 44(1), 61-70.
DOI Scopus73 WoS63 Europe PMC53
2009 Xian, C. J., & Zhou, X. F. (2009). Treating skeletal pain: limitations of conventional anti-inflammatory drugs, and anti-neurotrophic factor as a possible alternative. Nature clinical practice rheumatology, 5(2), 92-98.
DOI Scopus25 WoS22 Europe PMC17
2009 Li, F., Li, L., Song, X. Y., Zhong, J. H., Luo, X. G., Xian, C. J., & Zhou, X. F. (2009). Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor. European journal of neuroscience, 30(7), 1280-1296.
DOI Scopus20 WoS18 Europe PMC14
2008 Pyragius, C., Foster, B., & Xian, C. (2008). Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair. Journal of Cellular Physiology, 215(3), 578-587.
DOI Scopus145 WoS137 Europe PMC117
2008 Xian, C., Cool, J., Scherer, M., Fan, C., & Foster, B. (2008). Folinic acid attenuates methotrexate chemotherapy-induced damages on bone growth mechanisms and pools of bone marrow stromal cells. Journal of Cellular Physiology, 214(3), 777-785.
DOI Scopus47 WoS41 Europe PMC30
2007 Xian, C., Cool, J., Scherer, M., Pyragius, C., Fan, C., Covino, M., & Foster, B. (2007). Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects. Bone, 41(5), 842-850.
DOI Scopus87 WoS84 Europe PMC71
2007 Xian, C. (2007). Roles of epidermal growth factor family in the regulation of postnatal somatic growth. Endocrine Reviews, 28(3), 284-296.
DOI Scopus73 WoS69 Europe PMC60
2007 Xian, C., Cool, J., Van Gangelen, J., Foster, B., & Howarth, G. (2007). Effects of etoposide and cyclophosphamide acute chemotherapy on growth plate and metaphyseal bone in rats. Cancer Biology & Therapy, 6(2), 170-177.
DOI Scopus30 WoS28 Europe PMC27
2007 Macsai, C. E., Scherer, M. A., Zannettino, A., Foster, B. K., & Xian, C. J. (2007). Expression of Wnt signaling molecules at the injured growth plate cartilage in young rats. CALCIFIED TISSUE INTERNATIONAL, 80, S54.
WoS2
2006 Li, L., Xian, C., Zhong, J., & Zhou, X. (2006). Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats. Neurotoxicity Research, 9(4), 269-283.
DOI Scopus31 WoS29 Europe PMC26
2006 Xian, C., & Foster, B. (2006). Repair of injured articular and growth plate cartilage using mesenchymal stem cells and chondrogenic gene therapy. Current Stem Cell Research & Therapy, 1(2), 213-229.
DOI Scopus80 Europe PMC55
2006 Chung, R., Cool, J., Scherer, M., Foster, B., & Xian, C. (2006). Roles of neutrophil-mediated inflammatory response in the bony repair of injured growth plate cartilage in young rats. Journal of Leukocyte Biology, 80(6), 1272-1280.
DOI Scopus115 WoS103 Europe PMC91
2006 Xian, C., Cool, J., Pyragius, T., & Foster, B. (2006). Damage and recovery of mechanism in young rats the bone growth following 5-fluorouracil acute chemotherapy. Journal of Cellular Biochemistry, 99(6), 1688-1704.
DOI Scopus50 WoS50 Europe PMC46
2006 Arasapam, G., Scherer, M., Cool, J., Foster, B., & Xian, C. (2006). Roles of COX-2 and iNOS in the bony repair of the injured growth plate cartilage. Journal of Cellular Biochemistry, 99(2), 450-461.
DOI Scopus83 WoS73 Europe PMC65
2006 Ngo, T., Scherer, M., Zhou, F., Foster, B., & Xian, C. (2006). Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Journal of Histochemistry & Cytochemistry, 54(8), 945-954.
DOI Scopus37 WoS32 Europe PMC26
2006 Zhou, F., Foster, B., Zhou, X., Cowin, A., & Xian, C. (2006). TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. Journal of Bone and Mineral Research, 21(7), 1075-1088.
DOI Scopus132 WoS110 Europe PMC99
2005 Cool, J., Wright, J., Xian, C., Butler, R., Geier, M., & Howarth, G. (2005). Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats. Growth Hormone & IGF Research, 15(1), 72-82.
DOI Scopus61 WoS65 Europe PMC44
2005 Zhou, X., Li, W., Zhou, F., Zhong, J., Mi, J., Linyan Wu, L., & Xian, C. (2005). Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the P75 neurotrophin receptor. Neuroscience, 132(3), 591-603.
DOI Scopus42 WoS36 Europe PMC32
2004 Xian, C., & Zhou, X. (2004). EGF family of growth factors: essential roles and functional redundancy in the nerve system. Frontiers in Bioscience, 9(1-3), 85-92.
DOI Scopus63 WoS52 Europe PMC47
2004 Zhou, F., Foster, B., Sander, G., & Xian, C. (2004). Expression of proinflammatory cytokines and growth factors at the injured growth plate cartilage in young rats. Bone, 35(6), 1307-1315.
DOI Scopus82 WoS71 Europe PMC58
2004 Xian, C., Howarth, G., Cool, J., & Foster, B. (2004). Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats. Bone, 35(3), 739-749.
DOI Scopus41 WoS40 Europe PMC35
2004 Xian, C., Zhou, F., Mc Carty, R., & Foster, B. (2004). Intramembranous ossification mechanism for bone bridge formation at the growth plate cartilage injury site. Journal of Orthopaedic Research, 22(2), 417-426.
DOI Scopus102 WoS87 Europe PMC69
2003 Li, L., Xian, C., Zhong, J., & Zhou, X. (2003). Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain. Molecular and Cellular Neuroscience, 23(2), 232-250.
DOI Scopus51 WoS50 Europe PMC43
2003 Xian, C. (2003). Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Current Pharmaceutical Biotechnology, 4(4), 260-269.
DOI Scopus29 Europe PMC19
2002 Li, L., Xian, C., Zhong, J., & Zhou, X. (2002). Effect of lumbar 5 ventral root transection on pain behaviours: A novel rat model for neuropathic pain without axotomy of primary sensory neurons. Experimental Neurology, 175(1), 23-34.
DOI Scopus91 WoS88 Europe PMC79
2002 Xian, C., Cool, J., Howarth, G., & Read, L. (2002). Effects of TGF-α gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine. Journal of Cellular Physiology, 191(1), 105-115.
DOI Scopus26 WoS23 Europe PMC20
2002 Li, L., Xian, C. J., Zhong, J. H., & Zhou, X. F. (2002). Erratum: Effect of lumbar 5 ventral root transection on pain behaviors: A novel rat model for neuropathic pain without axotomy of primary sensory neurons (Experimental Neurology (2000) 175:1 (23-34) S0014488602978970). Experimental Neurology, 176(2), 407.
DOI Scopus1 WoS3
2001 Grose, R., Howarth, G. S., Xian, C. J., & Hohmann, A. (2001). Expression of B7-costimulatory molecules in rat ulcerative colitis. Awaiting ISSN.
2001 Xian, C. J., Lil, L., Deng, Y. S., Zhou, S. P., & Zhou, X. (2001). Lack of effects of transforming growth factor-alpha gene knockout on peripheral nerve regeneration may result from compensatory mechanisms. Experimental Neurology, 172(1), 182-188.
DOI Scopus24 WoS20 Europe PMC17
2001 Grose, R., Howarth, G., Xian, C., & Hohmann, A. (2001). Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse. Journal of Gastroenterology and Hepatology, 16(11), 1228-1234.
DOI Scopus14 WoS13 Europe PMC13
2001 Ferguson, I. A., Xian, C. J., Barati, E., & Rush, R. A. (2001). Comparison of wheat germ agglutinin-horseradish peroxidase and biotinylated dextran for anterograde tracing of corticospinal tract following spinal cord injury. Journal of Neuroscience Methods, 109(2), 81-89.
DOI Scopus17 WoS13 Europe PMC10
2001 Troyer, K. L., luetteke, N. C., Saxon, M. L., Qui, T. H., Xian, C. J., & Lee, D. C. (2001). Growth retardation duodenal lesions and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin and TGF-alpha. Gastroenterology, 121(1), 68-78.
DOI Scopus97 WoS89 Europe PMC76
2001 Xian, C. J., & Zhou, X. F. (2001). Sensitive and nonradioactive in situ detection of neurotrophin mRNAs in the nervous system.. Methods in Molecular Biology Clifton N J, 169, 91-98.
DOI Scopus3 Europe PMC2
2001 zhang, J., Lou, X., Xian, C. J., Liu, Z., & Zhou, X. (2001). Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents. European Journal of Neuroscience, 12(12), 4171-4180.
DOI Scopus245 WoS229 Europe PMC204
2000 Kallincos, N. C., Xian, C. J., Dunbar, A. J., Couper, R. T. L., & Read, L. C. (2000). Cloning of rat betacellulin and characterization of its expression in the gastrointestinal tract. Growth Factors, 18(3), 203-213.
DOI Scopus12 WoS9 Europe PMC5
2000 Zhou, X. F., Deng, Y. S., Xian, C. J., & Zhong, J. H. (2000). Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats. European Journal of Neuroscience, 12(1), 100-105.
DOI Scopus121 WoS113 Europe PMC100
2000 Howarth, G., Xian, C., & Read, L. (2000). Predisposition to colonic dysplasia is unaffected by continuous administration of insulin-like growth factor-I for twenty weeks in a rat model of chronic inflammatory bowel disease. Growth Factors, 18(2), 119-133.
DOI Scopus40 WoS37 Europe PMC29
2000 Xian, C., Couper, R., Howarth, G., Read, L., & Kallincos, N. (2000). Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis. British Journal of Cancer, 82(4), 945-952.
DOI Scopus48 WoS44 Europe PMC34
1999 Xian, C., Howarth, G., Mardell, C., Cool, J., Familari, M., Read, L., & Giraud, A. (1999). Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair. American Journal of Physiology - Gastrointestinal and Liver Physiology, 277(4 40-4), G785-G795.
DOI Scopus72 WoS63 Europe PMC43
1999 Xian, C., Xu, X., Mardell, C., Howarth, G., Byard, R., Moore, D., . . . Read, L. (1999). Site-specific changes in transforming growth factor-α and -β1 expression in colonic mucosa of adolescents with inflammatory bowel disease. Scandinavian Journal of Gastroenterology, 34(6), 591-600.
DOI Scopus24 WoS17 Europe PMC12
1999 Xian, C. J. (1999). Expression of transforming growth factor-α mRNA and peptide in rodent kidneys. Histochemistry and Cell Biology, 111(6), 467-475.
DOI Scopus5 WoS5 Europe PMC2
1999 Li, W. P., Xian, C., Rush, R. A., & Zhou, X. F. (1999). Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat. Neuroscience Letters, 260(1), 49-52.
DOI Scopus46 WoS44 Europe PMC40
1999 Xian, C. J., & Zhou, X. F. (1999). Neuronal-glial differential expression of TGF-α and its receptor in the dorsal root ganglia in response to sciatic nerve lesion. Experimental Neurology, 157(2), 317-326.
DOI Scopus52 WoS46 Europe PMC40
1999 Zhou, X. F., Chie, E. T., Deng, Y. S., Zhong, J. H., Xue, Q., Rush, R. A., & Xian, C. J. (1999). Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat. Neuroscience, 92(3), 841-853.
DOI Scopus150 WoS137 Europe PMC123
1999 Xian, C. J., Huang, B. R., & Zhou, X. F. (1999). Distribution of neurturin mRNA and immunoreactivity in the peripheral tissues of adult rats. Brain Research, 835(2), 247-258.
DOI Scopus20 WoS17 Europe PMC14
1999 Zhou, X. F., Deng, Y. S., Chie, E., Xue, Q., Zhong, J. H., McLachlan, E. M., . . . Xian, C. J. (1999). Satellite-cell-derived nerve growth factor and neurotrophin-3 are involved in noradrenergic sprouting in the dorsal root ganglia following peripheral nerve injury in the rat. European Journal of Neuroscience, 11(5), 1711-1722.
DOI Scopus207 WoS186 Europe PMC170
1999 Xian, C. J., Mardell, C. E., & Read, L. C. (1999). Specificity of the localization of transforming growth factor-α immunoreactivity in colon mucosa. Journal of Histochemistry and Cytochemistry, 47(7), 949-957.
DOI Scopus18 WoS12 Europe PMC11
1999 Xian, C. J., & Zhou, X. F. (1999). Roles of transforming growth factor-α and related molecules in the nervous system. Molecular Neurobiology, 20(2-3), 157-183.
DOI Scopus73 WoS72 Europe PMC62
1998 Penttila, I., van Spriel, A., Zhang, M., Xian, C., Steeb, C. B., Cummins, A., . . . Read, L. (1998). Transforming growth factor-β levels in maternal milk and expression in postnatal rat duodenum and ileum. Pediatric Research, 44(4), 524-531.
DOI Scopus90 WoS85 Europe PMC71
1998 Howarth, G., Xian, C., & Read, L. (1998). Insulin-like growth factor-I partially attenuates colonic damage in rats with experimental colitis induced by oral dextran sulphate sodium. Scandinavian Journal of Gastroenterology, 33(2), 180-190.
DOI Scopus73 WoS68 Europe PMC61
1996 Xian, C., Upton, Z., Goddard, C., Shoubridge, C., McNeil, K., Wallace, J., . . . Francis, G. (1996). Production of a human epidermal growth factor fusion protein and its degradation in rat gastrointestinal flushings. Journal of Molecular Endocrinolgy, 16(1), 89-97.
DOI Scopus3 WoS2 Europe PMC1
1995 Xian, C., Shoubridge, C., & Read, L. (1995). Degradation of IGF-1 in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein. Journal of Endocrinology, 146(2), 215-225.
DOI Scopus60 WoS53 Europe PMC30
1995 Xian, C. J., Simmons, R. D., Willenborg, D. O., Vandenbark, A. A., Hashim, G. A., & Carnegie, P. R. (1995). Studies on T‐cell receptors involved in experimental autoimmune encephalomyelitis using the complementary peptide recognition approach. Journal of Neuroscience Research, 41(5), 620-627.
DOI Scopus4 WoS3
1995 Xu, X., Mardell, C., Xian, C. J., Zola, H., & Read, L. C. (1995). Expression of functional insulin-like growth factor-1 receptor on lymphoid cell subsets of rats. Immunology, 85(3), 394-399.
Scopus25 WoS27 Europe PMC16
1991 Xian, J., & Farrell, D. J. (1991). The nutritive value of microwave-processed raw soya beans determined with chickens, rats and rabbits. Animal Feed Science and Technology, 34(1-2), 127-139.
DOI Scopus5 WoS4

Year Citation
2013 Chung, R., & Xian, C. J. (2013). Preclinical studies on growth plate cartilage regeneration using chondrocytes or mesenchymal stem cells. In M. K. Danquah, & R. I. Mahato (Eds.), Source details - Title: Emerging trends in cell and gene therapy (pp. 625-636). United States: Humana Press.
DOI
2013 Georgiou, K. R., & Xian, C. J. (2013). Role of Wnt/β-catenin signaling in bone marrow adiposity following cancer chemotherapy. In Y. Lin, & X. Cai (Eds.), Source details - Title: Adipogenesis: signaling pathways, molecular regulation and impact on human disease (pp. 109-126). US: Nova Science Publishers Inc.
2012 Fan, C., & Xian, C. J. (2012). Potential protection of bone growth using folinic acid during paediatric cancer chemotherapy. In H. S. Watanabe (Ed.), Source details - Title: Horizons in cancer research (Vol. 48, pp. 111-123). United States: Nova Science Publishers.
2012 Georgiou, K. R., & Xian, C. J. (2012). Damage and recovery of the bone and bone marrow following methotrexate chemotherapy. In V. S. Castillo, & L. A. Moyano (Eds.), Source details - Title: Methotrexate: update on pharmacology, clinical applications and warnings (pp. 199-207). US: Nova Science Publishers.
2012 Xian, C., & Shandala, T. (2012). Roles of EGF family of growth factors in growth: overview of their roles in postnatal growth and development. In V. Preedy (Ed.), Handbook of Growth and Growth Monitoring in Health and Disease (1 ed., pp. 2857-2870). United States: Springer.
DOI Scopus2
2010 Xian, C. J. (2010). Mechanisms of bony repair at the injured growth plate cartilage. In V. Legard, & R. Schluter (Eds.), Source details - Title: Bone regeneration: growth factors, augmentation procedures and tissue engineering applications (pp. 263-273). Hauppauge, NY: Nova Science Publishers.
2008 Xian, C. J., Chung, R., Macsai, C., & Foster, B. (2008). Injury responses and repair mechanisms at the injured growth plate cartilage of growing long bones. In Source details - Title: Research Advances in Histochemistry and Cytochemistry (pp. 1-7). Kerala, India: Global Research Network.
2002 Coates, P., & Wittert, G. (2002). Osteoporosis. In Practical guide to geriatric medicine (Vol. 20, pp. 797-809). Roseville, NSW: McGraw-Hill.
DOI Scopus2 WoS21 Europe PMC2

Year Citation
2023 Peymanfar, Y., Su, Y. -W., & Xian, C. (2023). Targeting Notch2 signalling to overcome methotrexate chemotherapy-induced bone loss and bone marrow adiposity in rats. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 38 (pp. 195). WILEY.
2021 Samarasinghe, C., Uddin, M., Bari, S., & Xian, C. (2021). Temperature and force generation in surgical bone drilling. In M. M. Alam, M. A. Rahman, & M. Ali (Eds.), AIP Conference Proceedings Vol. 2324 (pp. 1-8). US: American Institute of Physics.
DOI Scopus5 WoS5
2020 Samarasinghe, C., Uddin, M., Bari, S., & Xian, C. (2020). Surgical bone drilling: a review. In Conference proceedings: International Mechanical Engineering Congress and Exposition Vol. 3 (pp. 1-8). US: American Society of Mechanical Engineers.
DOI Scopus3 WoS1
2016 Wang, L. P., Hsu, H. Y., & Xian, C. J. (2016). Vibration analyses of a single osteoblast in vitro using the finite element method. In C. T. S. Ching (Ed.), Proceedings of the International Conference on Biomedical and Biological Engineering 2016 (BBE 2016) (pp. 380-385). Netherlands: Atlantis Press.
DOI
2014 Lee, A. M. C., Hua, B., Gregory, C., Morris, H., & Xian, C. (2014). POTENTIAL EFFECTS OF ANTI-INFLAMMATORY EMU OIL AND FISH OIL IN REDUCING AGEING-INDUCED BONE LOSS. In OSTEOPOROSIS INTERNATIONAL Vol. 25 (pp. 608). Taipei, TAIWAN: SPRINGER LONDON LTD.
2012 Xian, C. (2012). MECHANISMS AND PREVENTION OF BONE LOSS AND MARROW ADIPOSITY FOLLOWING CANCER CHEMOTHERAPY. In OSTEOPOROSIS INTERNATIONAL Vol. 23 (pp. S745-S746). Kuala Lumpur, MALAYSIA: SPRINGER LONDON LTD.
2011 Xian, C. (2011). MECHANISMS AND PREVENTION FOR CANCER CHEMOTHERAPY-INDUCED BONE DEFECTS. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S508). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Lee, A. M. C., Morrison, J. L., Botting, K. J., Shandala, T., & Xian, C. J. (2011). EFFECTS OF MATERNAL UNDERNUTRITION AND HYPOXIA DURING PREGNANCY ON BONE DEVELOPMENT OF OFFSPRING. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S663-S664). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Georgiou, K. R., King, T. J., Scherer, M. A., Foster, B. K., & Xian, C. J. (2011). METHOTREXATE CHEMOTHERAPY-INDUCED BONE LOSS AND MARROW ADIPOSITY IS ASSOCIATED WITH DEREGULATION OF THE WNT/B-CATENIN SIGNALLING PATHWAY. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S547). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011 Fan, C., Ng, Y. S., Shandala, F., Georgiou, K. R., King, T. J., Scherer, M., . . . Xian, C. J. (2011). Growth plate dysfunction, reduced osteogenesis, increased osteocyte apoptosis and osteoclastogenesis in methotrexate chemotherapy-induced bone growth defects. In BONE Vol. 48 (pp. S247). Athens, GREECE: ELSEVIER SCIENCE INC.
DOI
2010 Georgiou, K., Fan, C., Ng, Y., Shandala, T., King, T., Scherer, M., . . . Xian, C. (2010). Do cryopreserved autogenous cranial bone flaps remain viable at cranioplasty?. In BONE Vol. 47 (pp. S387-S388). Shenzhen, PEOPLES R CHINA: ELSEVIER SCIENCE INC.
DOI WoS3
2010 Georgiou, K., Fan, C., Ng, Y., Shandala, T., King, T., Scherer, M., . . . Xian, C. (2010). Skeletal cell apoptosis and changes in bone marrow microenvironment in methotrexate cancer chemotherapy-induced bone loss. In BONE Vol. 47 (pp. S388). Shenzhen, PEOPLES R CHINA: ELSEVIER SCIENCE INC.
DOI
2009 Shandala, T., Georgiou, K., Scherer, M., King, T., Foster, B., & Xian, C. (2009). Potential role of protein deacetylase Sirt1 in methotrexate chemotherapy-induced bone and bone marrow damage. In BONE Vol. 44 (pp. S166). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI WoS1
2009 Tran, C., Cool, J., & Xian, C. (2009). Effect of dietary zinc on small intestinal morphology and brush border enzymes in metallothionein-null and wild-type mice. In Journal of Gastroenterology and Hepatology Vol. 24 (pp. 0 pages). Australia: Wiley-Blackwell.
DOI WoS1
2009 Xian, C. J., Fan, C. M., Cool, J. C., Scherer, M. A., King, T., Georgiou, K., . . . Foster, B. K. (2009). Pathophysiology and prevention of cancer chemotherapy-induced bone growth defects. In BONE Vol. 45 (pp. S103). Cambridge, ENGLAND: ELSEVIER SCIENCE INC.
DOI
2009 McCarty, R. C., Gronthos, S., Zannettino, A. C., Foster, B. K., & Xian, C. J. (2009). Characterisation of ovine bone marrow derived mesenchymal stromal/stem cells and autologous application to growth plate cartilage defect. In BONE Vol. 45 (pp. S106-S107). Cambridge, ENGLAND: ELSEVIER SCIENCE INC.
DOI
2009 Georgiou, K. R., Scherer, M. A., Xian, C. J., & Foster, B. K. (2009). Damage and recovery of bone marrow microenvironment after acute Methotrexate chemotherapy. In BONE Vol. 44 (pp. S163). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI
2009 McCarty, R. C., Gronthos, S., Zannettino, A. C., Foster, B. K., & Xian, C. J. (2009). Characterisation of ovine bone marrow derived mesenchymal stem cells and autologous application to growth plate cartilage defect. In BONE Vol. 44 (pp. S159). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI
2008 Scherer, M., Georgiou, K., Cool, J., Foster, B., & Xian, C. (2008). Mechanisms for methotrexate chemotherapy-induced osteopenia and increased adipogenesis in the bone marrow in rats. In BONE Vol. 43 (pp. S38). Beijing, PEOPLES R CHINA: ELSEVIER SCIENCE INC.
DOI
2008 King, T., Scherer, M., Cool, J., Xu, J., Foster, B., & Xian, C. (2008). Osteoclastogenic cytokines - NF-κB signaling in methotrexate chemotherapy-induced osteoporosis. In BONE Vol. 43 (pp. S50). PEOPLES R CHINA, Beijing: ELSEVIER SCIENCE INC.
DOI
2008 Chung, R., Foster, B., & Xian, C. (2008). Potential roles of growth factor PDGF in the mesenchymal progenitor cell infiltration and bony repair at the injured growth plate. In BONE Vol. 43 (pp. S30). PEOPLES R CHINA, Beijing: ELSEVIER SCIENCE INC.
DOI
2008 Xian, C., Zhou, F., Chuog, R., Scherer, M., & Foster, B. (2008). The injury-induced initial inflammatory response modulates downstream bony repair events in the injured growth plate cartilage. In BONE Vol. 43 (pp. S34). PEOPLES R CHINA, Beijing: ELSEVIER SCIENCE INC.
DOI
2007 Xian, C. J., Cool, J., Scherer, M., Macsai, C., Fan, C., King, T., . . . Foster, B. (2007). Mechanisms for methotrexate chemotherapy-induced bone growth defects and protective effects of folinic acid supplementary treatment. In BONE Vol. 40 (pp. S87-S88). Montreal, CANADA: ELSEVIER SCIENCE INC.
DOI
2007 Xian, C. J., Zhou, F. H., Chung, R., Arasapam, G., Scherer, M., Cool, J., & Foster, B. K. (2007). 4th International Conference of Children's Bone health, Montreal, Canada, 2007 Growth Plate Cartilage Injury Responses and Repair Mechanisms. In BONE Vol. 40 (pp. S20-S21). Montreal, CANADA: ELSEVIER SCIENCE INC.
DOI
2007 Xian, C. J., Cool, J. C., Scherer, M. A., Macsai, C. E., Fan, C., & Foster, B. K. (2007). Suppression of endochondral bone formation by methotrexate chemotherapy and the protective effects of folinic acid supplementary treatment. In BONE Vol. 40 (pp. S174-S175). Montreal, CANADA: ELSEVIER SCIENCE INC.
WoS1
2007 King, T., Scherer, M. A., Cool, J. C., Georgiou, K., Foster, B. K., & Xian, C. J. (2007). Acute methotrexate chemotherapy increased expression of osteoclastogenic factors and osteoclastogenesis in bone. In BONE Vol. 40 (pp. S226). Montreal, CANADA: ELSEVIER SCIENCE INC.
2005 Xian, C. J., Cool, J., & Foster, B. K. (2005). Mechanisms for bone growth arrest and osteoporosis in young rats secondary to acute 5-fluorouracil chemotherapy. In BONE Vol. 36 (pp. S391-S392). Geneva, SWITZERLAND: ELSEVIER SCIENCE INC.

Year Citation
2014 Fan, C., Georgiou, K. R., McKinnon, R. A., Keefe, D. M., Howe, P. R., & Xian, C. J. (2014). ADVERSE EFFECTS OF COMBINATION BREAST CANCER CHEMOTHERAPY ON BONE AND BONE MARROW. Poster session presented at the meeting of OSTEOPOROSIS INTERNATIONAL. Taipei, TAIWAN: SPRINGER LONDON LTD.
2011 Fong, L., Muhlhausler, B., Gibson, R. A., & Xian, C. J. (2011). Effects of maternal dietary supplementation of omega-3 fatty acids during pregnancy and lactation on offspring's bone growth and adult bone mass. Poster session presented at the meeting of Bone. Athens, Greece: Elsevier.
DOI
2009 Xian, C. J., Fan, C., Cool, J., Sherer, M., King, T., Georgiou, K., . . . Foster, B. (2009). Pathobiology and prevention of bone growth defects caused by cancer chemotherapy. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD.

Year Citation
- Zhou, J., Chen, K. M., Zhi, D. J., Xie, Q. J., Xian, C. J., & Li, H. Y. (n.d.). Pyrite bioleaching solutions of Acidithiobacillus ferrooxidans promoted osteogenic differentiation of rat bone marrow mesenchymal stem cells through Wnt signaling.

  • NT-3 as an upstream and potentially master regulator promoting bone fracture healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2021

  • Preventing childhood glucocorticoid therapy-induced bone growth defects by blocking the aggravated chemokine SDF-1 signalling, Channel 7 Children's Research Foundation of SA, 14/11/2016 - 31/12/2018

  • Bone growth for healthy development: physiology, pathophysiology, and regeneration, NHMRC - Research Fellowship, 01/01/2013 - 31/12/2017

  • Preventing childhood methotrexate chemotherapy-induced bone loss by blocking the aggravated proosteoclastogenic cytokine - NF-kB signalling, Channel 7 Children's Research Foundation of SA, 01/01/2016 - 31/12/2017

  • Experimental and computational study on biomechanical behavior of osteocytes, NHMRC - Postgraduate Research Scholarship, 01/01/2015 - 14/03/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2014 - 2018 Co-Supervisor Mechanisms of Growth Failure in Mucopolysaccharidosis VII Mice Doctor of Philosophy Doctorate Full Time Miss Zhirui Jiang
2010 - 2011 Principal Supervisor Role of WNT/ß-Catenin and CXCL12/CXCR4 Signalling Axes in the Damage and Recovery of the Bone Marrow Microenvironment Following Methotrexate Chemotherapy Doctor of Philosophy Doctorate Full Time Ms Kristen Renee Georgiou
2010 - 2011 Principal Supervisor Cellular and Molecular Mechanisms Involved in Bony Tissue Repair of Injured Growth Plate Cartilage in Rats Doctor of Philosophy Doctorate Full Time Ms Rosa Chung
2006 - 2011 Principal Supervisor Prevention of Methotrexate Chemotherapy-Induced Bone Growth Arrest and Osteoporosis with Folinic Acid Doctor of Philosophy Doctorate Full Time Miss Chia Fan
2005 - 2012 Principal Supervisor Cellular and Molecular Mechanisms Involved in the Repair of the Injured Growth Plate in Young Rats Doctor of Philosophy Doctorate Full Time Miss Carmen Elizabeth Macsai
2002 - 2007 Principal Supervisor Roles of TNF-a Signalling and p38 Map Kinase Activation in the Responses to Growth Plate Injury in Young Rats Doctor of Philosophy Doctorate Full Time Dr Fiona Zhou
2002 - 2008 Principal Supervisor Ovine Bone Marrow Mesenchymal Stem Cells: Isolation, Characterisation, and Developmental Potential for Application in Growth Plate Cartilage Regeneration Doctor of Philosophy Doctorate Full Time Miss Rosa Mc Carty

Connect With Me

External Profiles

Other Links