Fiona Zhou

Dr Fiona Zhou

Grant-Funded Researcher (B)

SAIGENCI

College of Health


Fiona Zhou obtained her PhD at University of Adelaide studying the inflammatory response to growth plate injury which results in bony formation. After completion of her PhD, she conducted post-doctoral research in cartilage biology in the US followed by research in liver injury and neuroscience in Adelaide. During the past 3 years Fiona joined the Connie Johnson breast cancer research lab at the Garvan Institute in Sydney to begin her research in testing therapies to combat drug resistant Estrogen Receptor-positive breast cancer using in vitro and in vivo models. In 2025 Fiona has joined Dr Joanna Achinger-Kawecka in the 3D Chromatin Organisation Laboratory at SAiGENCI to continue her interests in cancer research using in vitro and in vivo cancer models of drug resistance to study what roles 3D chromatin alterations may play and identify potential therapeutic targets to test.

Date Position Institution name
2015 - ongoing Post doctoral Research officer University of Adelaide

Date Institution name Country Title
2002 - 2007 University of Adelaide Australia PhD
1998 - 2002 Flinders University, Adelaide Australia BBiotech (Hon)

Year Citation
2025 Alves, C. L., Karimi, L., Terp, M. G., Jakobsen, M. K., Zhou, F. H., Policastro, B., . . . Ditzel, H. J. (2025). Dual PI3K/mTOR inhibition is required to combat resistance to CDK4/6 inhibitor and endocrine therapy in <i>PIK3CA</i>-mutant breast cancer.. Science translational medicine, 17(829), eadp5088.
DOI
2024 Yang, C. -R., Liang, R., Liu, Y., Meng, F. -J., Zhou, F., Zhang, X. -Y., . . . Zhou, X. -F. (2024). Upregulation of proBDNF/p75NTR signaling in immune cells and its correlation with inflammatory markers in patients with major depression.. The FASEB Journal, 38(1), e23312-1-e23312-18.
DOI Scopus14 WoS11 Europe PMC11
2023 Zhou, F. H., Downton, T., Freelander, A., Hurwitz, J., Caldon, C. E., & Lim, E. (2023). CDK4/6 inhibitor resistance in estrogen receptor positive breast cancer, a 2023 perspective. Frontiers in Cell and Developmental Biology, 11, 1148792-1-1148792-12.
DOI Scopus45 WoS42
2022 Yang, C. R., Ding, H. J., Yu, M., Zhou, F. H., Han, C. Y., Liang, R., . . . Zhou, X. F. (2022). proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines. The FASEB Journal, 36(3), e22180-1-e22180-21.
DOI Scopus19 WoS19 Europe PMC18
2022 Downton, T., Zhou, F., Segara, D., Jeselsohn, R., & Lim, E. (2022). Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status. Drug Design, Development and Therapy, 16, 2933-2948.
DOI Scopus55 WoS52 Europe PMC48
2021 Otto, S., Marina, P. F., Zhou, F., & Blencowe, A. (2021). Thermoresponsive polysaccharides with tunable thermoresponsive properties via functionalisation with alkylamide groups. Carbohydrate Polymers, 254(117280), 1172801-117280-12.
DOI Scopus20 WoS18 Europe PMC10
2021 Zhou, S., Li, L., Chen, C., Chen, Y., Zhou, L., Zhou, F. H., . . . Wang, L. (2021). Injectable gelatin microspheres loaded with platelet rich plasma improve wound healing by regulating early inflammation. International Journal of Medical Sciences, 18(9), 1910-1920.
DOI Scopus22 WoS16 Europe PMC13
2021 Kelliny, S., Lin, L., Deng, I., Xiong, J., Zhou, F., Al-Hawwas, M., . . . Zhou, X. F. (2021). A new approach to model sporadic Alzheimer’s disease by intracerebroventricular streptozotocin injection in APP/PS1 mice. Molecular Neurobiology, 58(8), 3692-3711.
DOI Scopus19 WoS16 Europe PMC18
2021 Rychkov, G. Y., Zhou, F. H., Adams, M. K., Brierley, S. M., Ma, L., & Barritt, G. J. (2021). Orai1- and Orai2-, but not Orai3-mediated ⁄CRAC is regulated by intracellular pH. The Journal of Physiology, 600(3), 1-12.
DOI Scopus9 WoS7 Europe PMC9
2020 Liu, D., Rychkov, G., Al-Hawwas, M., Manaph, N. P. A., Zhou, F., Bobrovskaya, L., . . . Zhou, X. -F. (2020). Conversion of human urine-derived cells into neuron-like cells by small molecules. Molecular Biology Reports, 47(4), 1-10.
DOI Scopus18 WoS19 Europe PMC18
2020 Hu, S., Hu, M., Liu, J., Zhang, B., Zhang, Z., Zhou, F. H., . . . Dong, J. (2020). Phosphorylation of tau and α-synuclein induced neurodegeneration in MPTP mouse model of Parkinson’s disease. Neuropsychiatric Disease and Treatment, 16, 651-663.
DOI Scopus50 WoS47 Europe PMC40
2020 Shen, Y., Lu, H., Xu, R., Tian, H., Xia, X., Zhou, F. H., . . . Sun, L. (2020). The expression of GLAST and GLT1 in a transient cerebral ischemia mongolian gerbil model. Neuropsychiatric Disease and Treatment, 16, 789-800.
DOI Scopus10 WoS7 Europe PMC7
2020 Yang, C. R., Ning, L., Zhou, F. H., Sun, Q., Meng, H. P., Han, Z., . . . Zhou, X. -F. (2020). Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.. Neurotoxicity Research, 38(4), 914-928.
DOI Scopus17 WoS15 Europe PMC19
2020 Zeng, Z., Chen, J., Luo, S., Dong, J., Hu, H., Yang, Z., . . . Kang, L. (2020). Targeting and imaging colorectal cancer by activatable cell-penetrating peptides. American Journal of Translational Research, 12(5), 1754-1766.
Scopus7 WoS5 Europe PMC4
2020 Chen, J., Zeng, Z., Huang, L., Luo, S., Dong, J., Zhou, F. H., . . . Kang, L. (2020). Photothermal therapy technology of metastatic colorectal cancer. American Journal of Translational Research, 12(7), 3089-3115.
Scopus24 WoS22 Europe PMC19
2020 Yang, C. R., Zhang, X. Y., Liu, Y., Du, J. Y., Liang, R., Yu, M., . . . Zhou, X. F. (2020). Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress. Neurotoxicity Research, 37(1), 171-182.
DOI Scopus40 WoS38 Europe PMC33
2020 Cui, H., Cheng, Y., He, Y., Cheng, W., Zhao, W., Zhao, H., . . . Cai, S. (2020). The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model. Molecular Medicine Reports, 22(5), 3723-3734.
DOI Scopus17 WoS16 Europe PMC15
2019 Mañucat-Tan, N. B., Shen, L. L., Bobrovskaya, L., Al-hawwas, M., Zhou, F. H., Wang, Y. J., & Zhou, X. F. (2019). Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model. Aging, 11(17), 6762-6791.
DOI Scopus22 WoS20 Europe PMC17
2019 Chen, S., Liang, T., Zhou, F. H., Cao, Y., Wang, C., Wang, F. Y., . . . Li, C. Q. (2019). Regular music exposure in juvenile rats facilitates conditioned fear extinction and reduces anxiety after foot shock in adulthood. BioMed Research International, 2019(article no. 8740674), 1-10.
DOI Scopus15 WoS15 Europe PMC9
2018 Kheradpezhouh, E., Zhou, F., Barritt, G., & Rychkov, G. (2018). Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes. Biochemical and Biophysical Research Communications, 503(3), 1891-1896.
DOI Scopus16 WoS15 Europe PMC13
2017 Yang, C. R., Bai, Y. Y., Ruan, C. S., Zhou, F. H., Li, F., Li, C. Q., & Zhou, X. F. (2017). Injection of anti-proBDNF in anterior cingulate cortex (ACC) reverses chronic stress-induced adverse mood behaviors in mice. Neurotoxicity Research, 31(2), 298-308.
DOI Scopus32 WoS30 Europe PMC25
2017 Gavriliouk, D., Scrimgeour, N., Grigoryev, S., Ma, L., Zhou, F., Barritt, G., & Rychkov, G. (2017). Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH. Scientific Reports, 7(1), 9829-1-9829-12.
DOI Scopus15 WoS15 Europe PMC12
2016 Zhang, W., Garg, S., Eldi, P., Zhou, F., Johnson, I., Brooks, D., . . . Albrecht, H. (2016). Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide. International Journal of Pharmaceutics, 513(1-2), 270-279.
DOI Scopus28 WoS26 Europe PMC18
2016 Ali, E., Hua, J., Wilson, C., Tallis, G., Zhou, F., Rychkov, G., & Barritt, G. (2016). The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca²⁺ signalling in steatotic hepatocytes. Biochimica et Biophysica Acta-Molecular Cell Research, 1863(9), 2135-2146.
DOI Scopus41 WoS37 Europe PMC29
2016 Luo, C., Zhong, X. -L., Zhou, F. H., Li, J. -Y., Zhou, P., Xu, J. -M., . . . Dai, R. -P. (2016). Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator. Scientific Reports, 6(2, article no. 27171), 27171-1-27171-11.
DOI Scopus54 WoS52 Europe PMC49
2015 Meng, F. -F., Xu, Y., Dan, Q. -Q., Wei, L., Deng, Y. -J., Liu, J., . . . Wang, X. -Y. (2015). Intrathecal injection of lentivirus-mediated glial cell line-derived neurotrophic factor RNA interference relieves bone cancer-induced pain in rats. Cancer Science, 106(4), 430-437.
DOI Scopus14 WoS13 Europe PMC12
2015 Ruan, C., Zhou, F., He, Z., Wang, S., Yang, C., Shen, Y., . . . Zhou, X. (2015). Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors. Neuroscience, 293, 12-22.
DOI Scopus20 WoS18 Europe PMC15
2015 Zhou, F., Yu, Y., Zhou, X., & Xian, C. (2015). Methotrexate chemotherapy triggers touch-evoked pain and increased CGRP-positive sensory fibres in the tibial periosteum of young rats. Bone, 73, 24-31.
DOI Scopus5 WoS5 Europe PMC4
2015 Luo, C., Zhang, Y. -L., Luo, W., Zhou, F. H., Li, C. -Q., Xu, J. -M., & Dai, R. -P. (2015). Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex. Psychopharmacology, 232(24), 4433-4444.
DOI Scopus19 WoS19 Europe PMC15
2014 Jayasuriya, C., Zhou, F., Pei, M., Wang, Z., Lemme, N., Haines, P., & Chen, Q. (2014). Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells. International Journal of Molecular Sciences, 15(8), 14555-14573.
DOI Scopus24 WoS21 Europe PMC21
2014 Ruan, C., Wang, S., Shen, Y., Guo, Y., Yang, C., Zhou, F., . . . Zhou, X. (2014). Deletion of TRIM32 protects mice from anxiety- and depression-like behaviors under mild stress. The European journal of neuroscience, 40(4), 2680-2690.
DOI Scopus33 WoS31 Europe PMC30
2014 Yang, C., Zhang, Z., Bai, Y., Zhou, H., Zhou, L., Ruan, C., . . . Zhou, X. (2014). Foraging activity is reduced in a mouse model of depression. Neurotoxicity Research, 25(3), 235-247.
DOI Scopus22 WoS23 Europe PMC18
2014 Yang, C. R., Bai, Y. Y., Ruan, C. S., Zhou, H. F., Liu, D., Wang, X. F., . . . Zhou, X. F. (2014). Enhanced aggressive behaviour in a mouse model of depression. Neurotoxicity Research, 27(2), 129-142.
DOI Scopus48 WoS50 Europe PMC37
2014 Li, C. -Q., Luo, Y. -W., Bi, F. -F., Cui, T. -T., Song, L., Cao, W. -Y., . . . Dai, R. -P. (2014). Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment. Neuropsychopharmacology, 39(12), 2777-2787.
DOI Scopus61 WoS57 Europe PMC49
2013 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., . . . Zhou, X. (2013). Mature BDNF promotes the growth of glioma cells in vitro. Oncology Reports, 30(6), 2719-2724.
DOI Scopus43 WoS39 Europe PMC35
2009 Song, X. Y., Zhang, F. H., Zhou, F. H., Zhong, J., & Zhou, X. F. (2009). Deletion of p75NTR impairs regeneration of peripheral nerves in mice. Life sciences, 84(3-4), 61-68.
DOI Scopus15 WoS14 Europe PMC12
2008 Fitzgerald, J., Rich, C., Zhou, F. H., & Hansen, U. (2008). Three novel collagen VI chains, α4(VI), α5(VI), and α6(VI). Journal of Biological Chemistry, 283(29), 20170-20180.
DOI Scopus161 WoS147 Europe PMC141
2006 Song, X., Zhou, F., Zhong, J., Linyan Wu, L., & Zhou, X. (2006). Knockout of p75NTR impairs re-myelination of injured sciatic nerve in mice. Journal of Neurochemistry, 96(3), 833-842.
DOI Scopus73 WoS70 Europe PMC62
2006 Ngo, T., Scherer, M., Zhou, F., Foster, B., & Xian, C. (2006). Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Journal of Histochemistry & Cytochemistry, 54(8), 945-954.
DOI Scopus38 WoS33 Europe PMC27
2006 Zhou, F., Foster, B., Zhou, X., Cowin, A., & Xian, C. (2006). TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. Journal of Bone and Mineral Research, 21(7), 1075-1088.
DOI Scopus134 WoS111 Europe PMC100
2005 Zhou, X., Li, W., Zhou, F., Zhong, J., Mi, J., Linyan Wu, L., & Xian, C. (2005). Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the P75 neurotrophin receptor. Neuroscience, 132(3), 591-603.
DOI Scopus42 WoS36 Europe PMC32
2004 Zhou, F., Foster, B., Sander, G., & Xian, C. (2004). Expression of proinflammatory cytokines and growth factors at the injured growth plate cartilage in young rats. Bone, 35(6), 1307-1315.
DOI Scopus84 WoS72 Europe PMC59
2004 Xian, C., Zhou, F., Mc Carty, R., & Foster, B. (2004). Intramembranous ossification mechanism for bone bridge formation at the growth plate cartilage injury site. Journal of Orthopaedic Research, 22(2), 417-426.
DOI Scopus103 WoS88 Europe PMC70
2004 Zhou, X. F., Song, X. Y., Zhong, J. H., Barati, S., Zhou, F. H. H., & Johnson, S. M. (2004). Distribution and localization of pro-brain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat. Journal of Neurochemistry, 91(3), 704-715.
DOI Scopus83 WoS77 Europe PMC67
2003 Penttila, I., Flesch, I., McCue, A., Powell, B., Zhou, F., Read, L., & Zola, H. (2003). Maternal milk regulation of cell infiltration and interleukin 18 in the intestine of suckling rat pups. Gut, 52(11), 1579-1586.
DOI Scopus40 Europe PMC33

Year Citation
2007 Xian, C. J., Zhou, F. H., Chung, R., Arasapam, G., Scherer, M., Cool, J., & Foster, B. K. (2007). 4th International Conference of Children's Bone health, Montreal, Canada, 2007 Growth Plate Cartilage Injury Responses and Repair Mechanisms. In BONE Vol. 40 (pp. S20-S21). Montreal, CANADA: ELSEVIER SCIENCE INC.
DOI

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