Professor Claire Roberts

Claire Roberts
Senior Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences

Professor Claire Roberts is a graduate of Flinders University (BA 1985) and the University of Adelaide (BSc 1988, BSc Hons 1990, PhD 1995). She is Deputy Director of the Robinson Research Institute at the University of Adelaide South Australia where she leads the Pregnancy and Birth Theme and the Cohort and Intergenerational Studies Facility.

Claire Roberts is a placental biologist and pregnancy researcher. Her research takes a bench to bedside approach and includes in vitro and animal models, and human pregnancy cohort and placental studies to unravel the complex cellular and molecular mechanisms that underpin dynamic placental differentiation and function across gestation, fetal growth and development and pregnancy success.

Claire has a strong interest in clinical and lifestyle factors such as maternal BMI, socio-economic and micronutrient status that together interact with genetic factors to influence health in pregnancy and beyond.

Claire Roberts’ research has been funded by NHMRC, NIH NICHD, the Premier’s Science and Research Fund SA government and Channel 7 Children’s Research Foundation.

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Professor Claire Roberts

Professor Claire Roberts is a graduate of Flinders University (BA 1985) and the University of Adelaide (BSc 1988, BSc Hons 1990, PhD 1995). She is Deputy Director of the Robinson Research Institute at the University of Adelaide South Australia where she leads the Pregnancy and Birth Theme and the Cohort and Intergenerational Studies Facility.

Claire Roberts is a placental biologist and pregnancy researcher. Her research takes a bench to bedside approach and includes in vitro and animal models, and human pregnancy cohort and placental studies to unravel the complex cellular and molecular mechanisms that underpin dynamic placental differentiation and function across gestation, fetal growth and development and pregnancy success.

Claire has a strong interest in clinical and lifestyle factors such as maternal BMI, socio-economic and micronutrient status that together interact with genetic factors to influence health in pregnancy and beyond.

Claire Roberts’ research has been funded by NHMRC, NIH NICHD, the Premier’s Science and Research Fund SA government and Channel 7 Children’s Research Foundation.

Research Projects
1. Screening for risk for pregnancy complications and applying results of basic research to clinical problems

We were funded by Government of South Australia to develop predictive tests for couples' risks for complications of late pregnancy, specifically preeclampsia, IUGR, preterm birth and gestational diabetes. This is the Adelaide arm of the SCOPE (SCreening fOr Pregnancy Endpoints) project. SCOPE is an international consortium of clinicians and scientists who by the end of 2011 had assembled a biobank and detailed clinical and lifestyle database for 5,628 women pregnant for the first time and their partners. Recruiting has ceased in all SCOPE centres.  In Adelaide we initially undertook a targeted gene approach and aimed to identify maternal and paternal genes that determine a couple's risk prior to the development of symptoms. These genes have already been shown to be important in the control of placental development, cardiovascular disease, inflammation and cancer. We have a particular interest in how the father imparts risk for pregnancy complications in the mother and baby.
We have recently developed 3-tiered algorithms to predict risk in early pregnancy for subsequent preeclampsia, preterm birth, IUGR and gestational diabetes using combinations of genetic, clinical, family history and lifestyle factors.
We began recruiting women to the Screening Tests to Predict Poor Outcomes of Pregnancy (STOP) study in March 2015. We aim to validate our risk prediction algorithms in this cohort. We expect to have recruited 1,400 women to this cohort by the end of 2017. We will utilise our new software designed to provide an individualised probability of risk for each couple in the STOP Study. We will also continue to collect important clinical and lifestyle data about each pregnancy and health of both mother and child to answer new questions in obstetric research including effects of maternal diet and micronutrient supplementation on pregnancy outcome.
We have another cohort Predicting Adverse Pregnancy Outcomes (PAPO) in whom women suffer recurrent pregnancy complications but primarily recurrent spontaneous miscarriage (RSM). It appears that RSM is in the continuum of pregnancy complications associated with poor placentation. We aim to elucidate molecular mediators in RSM and identify potential therapeutic targets for subsequent development and testing.

 

2. The role of Vitamin D in the placenta and pregnancy success

In recent years, vitamin D has emerged as a micronutrient important for optimal pregnancy outcome. In women, vitamin D deficiency has been associated with complications of pregnancy including preeclampsia, intrauterine growth restriction, gestational diabetes, preterm birth and a greater need for caesarean section but the data are conflicting. Although our understanding of the specific functions of vitamin D in pregnancy is scant, it seems likely that vitamin D deficiency may play a role in complicated pregnancies because robust regulation of vitamin D activation and degradation occurs locally in the placenta. Animal studies have shown that maternal vitamin D deficiency is associated with excessive inflammation in the uterus underlying the placenta (decidua) that impacts fetal growth and health.
Perhaps the best known function of vitamin D is in the maintenance of calcium balance. Indeed, calcium supplementation in women with low dietary calcium has been shown to prevent preeclampsia. However, little is known of the mechanisms by which vitamin D and calcium act in the placenta and in maternal adaptation to pregnancy. We are working to elucidate the molecular mechanisms by which vitamin D and calcium affect placentation and pregnancy outcome.

 

3. Developing omic profiles in maternal blood that reflect those in the placenta

We have been funded by NIH NICHD to develop a non-invasive method to assess placental function across gestation in real time. Using our biobank of placental samples obtained right across gestation with matched maternal blood samples we have been using genome and epigenome wide sequencing technologies to profile placental health. These will be integrated with other data we hold about these pregnancies that indicate aspects of placental function. 

 

4. Epigenetic programming of placental and fetal development

The placenta is derived from the conceptus and is therefore genetically identical to the fetus. Perhaps the best known function of the placenta is to transport gases, nutrients and wastes between mother and fetus. However, the placenta also plays a major role in orchestrating maternal adaptation to pregnancy by secreting a variety of steroid and peptide hormones. These placental hormones stimulate maternal physiological changes that are essential for pregnancy success. To facilitate these functions the placenta invades the decidua, colonizing and transforming the uterine spiral arterioles to sequester a maternal blood supply for efficient maternal-fetal exchange. Invading placental extravillous cytotrophoblasts employ molecular mechanisms that closely match those of a metastatic tumor but unlike cancer this process is strictly controlled both spatially and temporally in the placenta. Such mechanisms are not fully understood but include complex interactions between both extravillous cytotrophoblasts and maternal endothelium and leukocytes.
Emerging evidence suggests that epigenetic regulation of the placental transcriptome is important for the molecular control of placental growth and differentiation. However, the epigenetic landscape affecting placental gene expression may be different to that in other healthy tissues and the role of epigenetic modifications, and particularly DNA methylation, in placental development remains largely unknown. Of particular interest is the fact that the placenta is the most hypomethylated human tissue and is characterized by the presence of large partially methylated domains (PMDs) containing silenced genes. We are working to understand how and why the placenta is hypomethylated and what role DNA methylation plays in regulating placental gene expression across gestation.

 

5. Interactions between maternal micronutrient status, obesity and metabolic health in disadvantaged women 

Large numbers of pregnant women supplement with folic acid in Australia to prevent neural tube defects. This has been shown to be effective for this purpose. However, many supplement formulations that target pregnant women also include a number of other micronutrients with or without good evidence for their benefits. There are some data suggesting positive effects on maternal health and others showing that deficiencies affect child health and well being. There are some data that show that some groups of women benefit such as those who are obese but not all. We aim to determine how maternal status for various micronutrients interacts with obesity, placental genetics and epigenetics to effect maternal and child outcomes.

Appointments

Date Position Institution name
2017 Lloyd Cox Professorial Research Fellow University of Adelaide
2015 Deputy Director Robinson Research Institute
2015 Convenor Healthy Development Adelaide
2014 Pregnancy and Birth Theme Leader Robinson Research Institute
2012 - 2016 NHMRC Senior Research Fellow B University of Adelaide
2011 - 2012 Senior Research Fellow University of Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2016 Inflammation in Reproduction, Pregnancy and Development
2015 Professor Donald Cheek Award
2015 Lloyd Cox Strategic Research Excellence Award
2015 Fellow of the Society for Reproductive Biology
2014 School of Paediatrics and Reproductive Health Award for Excellence in HDR Supervision
2012 ASPIRE International Congress Osaka Japan

Education

Date Institution name Country Title
1995 University of Adelaide Australia PhD
1990 University of Adelaide Australia BSc Hons
1988 University of Adelaide Australia BSc
1985 Flinders University Australia BA

Journals

Date Citation
2017 Buckberry,S, Bianco-Miotto,T, Bent,S, Clifton,V, Shoubridge,C, Shankar,K, Roberts,C, 2017, Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation, BMC Genomics, 18, 1, 10-1-10-13 10.1186/s12864-016-3384-9
2017 Roberts,C, 2017, Biomedical research: Premature lambs grown in a bag, Nature, 546, 7656, 45-46 10.1038/546045a
2017 Vieira,M, Poston,L, Fyfe,E, Gillett,A, Kenny,L, Roberts,C, Baker,P, Myers,J, Walker,J, Mccowan,L et al, 2017, Clinical and biochemical factors associated with preeclampsia in women with obesity, Obesity, 25, 2, 460-467 10.1002/oby.21715
2017 Hodyl,N, Aboustate,N, Bianco-Miotto,T, Roberts,C, Clifton,V, Stark,M, 2017, Child neurodevelopmental outcomes following preterm and term birth: What can the placenta tell us?, Placenta, 57, 79-86 10.1016/j.placenta.2017.06.009
2017 McCowan,L, Thompson,J, Taylor,R, Baker,P, North,R, Poston,L, Roberts,C, Simpson,N, Walker,J, Myers,J et al, 2017, Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers, PLoS One, 12, 1, 0169311-1-0169311-15 10.1371/journal.pone.0169311
2017 Andraweera,PH, Dekker,GA, Arstall,M, Bianco-Miotto,T, Roberts,CT, 2017, Complications of pregnancy and future cardiovascular risk, Encyclopedia of Cardiovascular Research and Medicine, -
2017 Highet,A, Bianco-Miotto,T, Pringle,K, Peura,A, Bent,S, Zhang,J, Nottle,M, Thompson,J, Roberts,C, 2017, A novel embryo culture media supplement that improves pregnancy rates in mice, Reproduction, 153, 3, 327-340 10.1530/REP-16-0517
2017 Estrella,C, Kind,K, Derks,A, Xiang,R, Faulkner,N, Mohrdick,M, Fitzsimmons,C, Kruk,Z, Grutzner,F, Roberts,C et al, 2017, Remodelling of the bovine placenta: Comprehensive morphological and histomorphological characterization at the late embryonic and early accelerated fetal growth stages, Placenta, 55, 37-46 10.1016/j.placenta.2017.04.009
2017 McAninch,D, Roberts,C, Bianco-Miotto,T, 2017, Mechanistic insight into long noncoding RNAs and the placenta, International Journal of Molecular Sciences, 18, 7, 1371-1371 10.3390/ijms18071371
2017 Gatford,KL, Muhlhausler,BS, Huang,L, Sim,PS-L, Roberts,CT, Velhuis,JD, Chen,C, 2017, Rising maternal circulating GH during murine pregnancy suggests placental regulation, ENDOCRINE CONNECTIONS, 6, 4, 260-266 10.1530/EC-17-0032
2017 Novakovic,B, Fournier,T, Harris,L, James,J, Roberts,C, Yong,H, Kalionis,B, Evain-Brion,D, Ebeling,P, Wallace,E et al, 2017, Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation, Scientific Reports, 7, 1, - 10.1038/s41598-017-04776-5
2017 Van Der Hoek,K, Eyre,N, Shue,B, Khantisitthiporn,O, Glab-Ampi,K, Carr,J, Gartner,M, Jolly,L, Thomas,P, Adikusuma,F et al, 2017, Viperin is an important host restriction factor in control of Zika virus infection, Scientific Reports, 7, 1, - 10.1038/s41598-017-04138-1
2017 Andraweera,P, Gatford,K, Dekker,G, Leemaqz,S, Jayasekara,R, Dissanayake,V, McCowan,L, Roberts,C, 2017, The INSR rs2059806 single nucleotide polymorphism, a genetic risk factor for vascular and metabolic disease, associates with pre-eclampsia, Reproductive BioMedicine Online, 34, 4, 392-398 10.1016/j.rbmo.2017.01.001
2016 Bianco-Miotto,T, Mayne,B, Buckberry,S, Breen,J, Rodriguez Lopez,C, Roberts,C, 2016, Recent progress towards understanding the role of DNA methylation in human placental development, Reproduction, 152, 1, 23-30 10.1530/REP-16-0014
2016 Cecatti,J, Souza,R, Sulek,K, Costa,M, Kenny,L, McCowan,L, Pacagnella,R, Villas-Boas,S, Mayrink,J, Passini,R et al, 2016, Use of metabolomics for the identification and validation of clinical biomarkers for preterm birth: Preterm SAMBA, BMC Pregnancy and Childbirth, 16, 1, - 10.1186/s12884-016-1006-9
2016 Mayne,B, Leemaqz,S, Smith,A, Breen,J, Roberts,C, Bianco-Miotto,T, 2016, Accelerated placental aging in early onset preeclampsia pregnancies identified by DNA methylation., Epigenomics, 9, 3, 279-289 10.2217/epi-2016-0103
2016 Andraweera,P, Dekker,G, Leemaqz,S, McCowan,L, Roberts,C, 2016, The obesity associated FTO gene variant and the risk of adverse pregnancy outcomes: evidence from the SCOPE study, Obesity, 24, 12, 2600-2607 10.1002/oby.21662
2016 Leemaqz,S, Dekker,G, McCowan,L, Kenny,L, Myers,J, Simpson,N, Poston,L, Roberts,C, 2016, Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications, Reproductive Toxicology, 62, 77-86 10.1016/j.reprotox.2016.04.021
2016 Mayne,B, Leemaqz,S, Buckberry,S, Breen,J, Bianco-Miotto,T, Roberts,C, 2016, Sex differences in the human placental methylome, CLINICAL ENDOCRINOLOGY, 84, 48-48
2016 Wilson,R, Grieger,J, Bianco-Miotto,T, Roberts,C, 2016, Association between maternal zinc status, dietary zinc intake and pregnancy complications: a systematic review, Nutrients, 8, 10, 1-28 10.3390/nu8100641
2016 Hodyl,N, Roberts,C, Bianco-Miotto,T, 2016, Cord blood DNA methylation biomarkers for predicting neurodevelopmental outcomes, Genes, 7, 12, 117-117 10.3390/genes7120117
2016 Lie,S, Morrison,J, Williams-Wyss,O, Suter,C, Humphreys,D, Ozanne,S, Zhang,S, Maclaughlin,S, Kleemann,D, Walker,S et al, 2016, Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses, American Journal of Physiology: Endocrinology and Metabolism, 310, 2, E148-E159 10.1152/ajpendo.00600.2014
2016 Mayne,B, Bianco-Miotto,T, Buckberry,S, Breen,J, Clifton,V, Shoubridge,C, Roberts,C, 2016, Large scale gene expression meta-analysis reveals tissue-specific, sex-biased gene expression in humans, Frontiers in Genetics, 7, OCT, 183-1-183-14 10.3389/fgene.2016.00183
2016 Highet,A, Buckberry,S, Mayne,B, Khoda,S, Bianco-Miotto,T, Roberts,C, 2016, First trimester trophoblasts forming endothelial-like tubes in vitro emulate a ‘blood vessel development’ gene expression profile, Gene Expression Patterns, 21, 2, 103-110 10.1016/j.gep.2016.05.001
2016 Delforce,S, Wang,Y, Van-Aalst,M, Corbisier De Meaultsart,C, Morris,B, Broughton-Pipkin,F, Roberts,C, Lumbers,E, Pringle,K, 2016, Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line, Placenta, 37, 1-6 10.1016/j.placenta.2015.11.011
2016 Andraweera,P, Dekker,G, Jayasekara,R, Dissanayake,V, Roberts,C, 2016, Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women, Journal of Maternal-Fetal & Neonatal Medicine, 29, 7, 1072-1076 10.3109/14767058.2015.1034102
2016 Verburg,P, Tucker,G, Scheil,W, Erwich,J, Dekker,G, Roberts,C, 2016, Seasonality of gestational diabetes mellitus: A South Australian population study, BMJ Open Diabetes Research and Care, 4, 1, 1-8 10.1136/bmjdrc-2016-000286
2016 Verburg,P, Tucker,G, Scheil,W, Erwich,J, Dekker,G, Roberts,C, 2016, Sexual dimorphism in adverse pregnancy outcomes - A retrospective Australian population study 1981-2011, PLoS ONE, 11, 7, - 10.1371/journal.pone.0158807
2016 Andraweera,P, Bobek,G, Bowen,C, Burton,G, Correa Frigerio,P, Chaparro,A, Dickinson,H, Duncombe,G, Hyett,J, Illanes,S et al, 2016, IFPA meeting 2015 workshop report II: mechanistic role of the placenta in fetal programming; biomarkers of placental function and complications of pregnancy, Placenta, 48, S7-S11 10.1016/j.placenta.2015.12.012
2016 Zhang,S, Barker,P, Botting,K, Roberts,C, McMillan,C, McMillen,I, Morrison,J, 2016, Early restriction of placental growth results in placental structural and gene expression changes in late gestation independent of fetal hypoxemia, Physiological Reports, 4, 23, e13049-1-e13049-19 10.14814/phy2.13049
2016 Mol,B, Roberts,C, Thangaratinam,S, Magee,L, De Groot,C, Hofmeyr,G, 2016, Pre-eclampsia, The Lancet, 387, 10022, 999-1011 10.1016/S0140-6736(15)00070-7
2015 Stockham,S, Stamford,J, Roberts,C, Fitzsimmons,T, Marchant,C, Bartold,P, Zilm,P, 2015, Abnormal pregnancy outcomes in mice using an induced periodontitis model and the haematogenous migration of Fusobacterium nucleatum sub-species to the murine placenta, PLoS One, 10, 3, e0120050-1-e0120050-16 10.1371/journal.pone.0120050
2015 Andraweera,P, Gatford,K, Dekker,G, Leemaqz,S, Russell,D, Thompson,S, McCowan,L, Roberts,C, 2015, Insulin family polymorphisms in pregnancies complicated by small for gestational age infants, Molecular Human Reproduction, 21, 9, 745-752 10.1093/molehr/gav031
2015 Wilson,R, Buckberry,S, Spronk,F, Laurence,J, Leemaqz,S, O'Leary,S, Bianco-Miotto,T, Du,J, Anderson,P, Roberts,C et al, 2015, Vitamin D receptor gene ablation in the conceptus has limited effects on placental morphology, function and pregnancy outcome, PLoS One, 10, 6, e0131287-1-e0131287-17 10.1371/journal.pone.0131287
2015 Buckberry,S, Spronk,F, Wilson,R, Laurence,J, Bianco-Miotto,T, Leemaqz,S, O'Leary,S, Anderson,P, Roberts,C, 2015, The effect of Vdr gene ablation on global gene expression in the mouse placenta, Genomics Data, 6, 72-73 10.1016/j.gdata.2015.08.022
2015 Highet,A, Khoda,S, Buckberry,S, Leemaqz,S, Bianco-Miotto,T, Harrington,E, Ricciardelli,C, Roberts,C, 2015, Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion, European Journal of Cell Biology, 94, 12, 589-602 10.1016/j.ejcb.2015.10.004
2015 Lie,S, Morrison,J, Williams-Wyss,O, Suter,C, Humphreys,D, Ozanne,S, Zhang,S, MacLaughlin,S, Kleemann,D, Walker,S et al, 2015, Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep, Physiological Reports, 3, 8, e12495-1-e12495-15 10.14814/phy2.12495
2015 Andraweera,P, Dekker,G, Jayasekara,R, Dissanayake,V, Roberts,C, 2015, The obesity-related FTO gene variant associates with the risk of recurrent miscarriage, Acta Obstetricia et Gynecologica Scandinavica, 94, 7, 722-726 10.1111/aogs.12640
2015 Standen,P, Sferruzzi-Perri,A, Taylor,R, Heinemann,G, Zhang,J, Highet,A, Pringle,K, Owens,J, Kumarasamy,V, Lumbers,E et al, 2015, Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig, Growth Hormone & IGF Research, 25, 3, 141-147 10.1016/j.ghir.2015.02.001
2015 Myers,JE, Thomas,G, Tuytten,R, Van Herrewege,Y, Djiokep,RO, Roberts,CT, Kenny,LC, Simpson,NAB, North,RA, Baker,PN et al, 2015, Mid-trimester maternal ADAM12 levels differ according to fetal gender in pregnancies complicated by preeclampsia, Reproductive Sciences, 22, 2, 235-241 10.1177/1933719114537713
2015 Zhang,S, Regnault,T, Barker,P, Botting,K, McMillen,I, McMillan,C, Roberts,C, Morrison,J, 2015, Placental adaptations in growth restriction, Nutrients, 7, 1, 360-389 10.3390/nu7010360
2014 Andraweera,P, Dekker,G, Thompson,S, Dissanayake,V, Jayasekara,R, Roberts,C, 2014, Hypoxia-inducible factor-1α gene polymorphisms in early and late onset preeclampsia in Sinhalese women, Placenta, 35, 7, 491-495 10.1016/j.placenta.2014.04.008
2014 Gatford,K, Heinemann,G, Thompson,S, Zhang,J, Buckberry,S, Owens,J, Dekker,G, Roberts,C, 2014, Circulating IGF1 and IGF2 and SNP genotypes in men and pregnant and non-pregnant women, Endocrine Connections, 3, 3, 138-149 10.1530/EC-14-0068
2014 Buckberry,S, Bianco-Miotto,T, Roberts,C, 2014, Imprinted and X-linked non-coding RNAs as potential regulators of human placental function, Epigenetics, 9, 1, 81-89 10.4161/epi.26197
2014 Sykes,S, Pringle,K, Zhou,A, Dekker,G, Roberts,C, Lumbers,E, 2014, The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex, Journal of Renin-Angiotensin-Aldosterone System, 15, 4, 523-531 10.1177/1470320313477174
2014 Buckberry,S, Bent,S, Bianco-Miotto,T, Roberts,C, 2014, MassiR: A method for predicting the sex of samples in gene expression microarray datasets, Bioinformatics, 30, 14, 2084-2085 10.1093/bioinformatics/btu161
2014 Sykes,S, Pringle,K, Zhou,A, Dekker,G, Roberts,C, Lumbers,E, 2014, Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension, Journal of Human Hypertension, 28, 2, 133-139 10.1038/jhh.2013.51
2014 Buckberry,S, Bianco-Miotto,T, Bent,S, Dekker,G, Roberts,C, 2014, Integrative transcriptome meta-analysis reveals widespread sex-biased gene expression at the human fetal-maternal interface, Molecular Human Reproduction, 20, 8, 810-819 10.1093/molehr/gau035
2014 Kenny,L, Black,M, Poston,L, Taylor,R, Myers,J, Baker,P, McCowan,L, Simpson,N, Dekker,G, Roberts,C et al, 2014, Early pregnancy prediction of preeclampsia in nulliparous women, combining clinical risk and biomarkers : the screening for pregnancy endpoints (SCOPE) international cohort study, Hypertension, 64, 3, 644-652 10.1161/HYPERTENSIONAHA.114.03578
2014 Lie,S, Morrison,J, Williams-Wyss,O, Suter,C, Roberts,C, 2014, Periconceptional undernutrition programs changes in insulin-signaling molecules and microRNAs in skeletal muscle in singleton and twin fetal sheep, Biology of Reproduction, 90, 1, 1-10 10.1095/biolreprod.113.109751
2014 Andraweera,P, Dekker,G, Thompson,S, Nowak,R, Jayasekara,R, Dissanayake,V, Roberts,C, 2014, Polymorphisms in the fibrinolytic pathway genes and the risk of recurrent spontaneous abortion, Reproductive BioMedicine Online, 29, 6, 745-751 10.1016/j.rbmo.2014.08.014
2014 Williams-Wyss,O, Zhang,S, MacLaughlin,SM, Kleemann,D, Walker,SK, Suter,CM, Cropley,JE, Morrison,JL, Roberts,CT, Caroline McMillen,I et al, 2014, Embryo number and periconceptional undernutrition in the sheep have differential effects on adrenal epigenotype, growth, and development, American Journal of Physiology: Endocrinology and Metabolism, 307, 2, E141-E150 10.1152/ajpendo.00051.2012
2014 Lie,S, Morrison,J, Williams-Wyss,O, Suter,C, Humphreys,D, Ozanne,S, Zhang,S, MacLaughlin,S, Kleemann,D, Walker,S et al, 2014, Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep, American Journal of Physiology: Endocrinology and Metabolism, 306, 9, E1013-E1024 10.1152/ajpendo.00553.2013
2013 Myers,J, Tuytten,R, Thomas,G, Laroy,W, Kas,K, Vanpoucke,G, Roberts,C, Kenny,L, Simpson,N, Baker,P et al, 2013, Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia, Hypertension, 61, 6, 1281-1329 10.1161/HYPERTENSIONAHA.113.01168
2013 Ahmed,M, Aleksunes,L, Boeuf,P, Chung,M, Daoud,G, Desoye,G, Diaz,P, Golos,T, Illsley,N, Kikuchi,K et al, 2013, IFPA Meeting 2012 Workshop Report II: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta, Placenta, 34, SUPPL, S6-S10 10.1016/j.placenta.2012.11.020
2013 Zhou,A, Dekker,G, Lumbers,E, Leemaqz,S, Thompson,S, McCowan,L, Roberts,C, 2013, The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI, Placenta, 34, 1, 75-81 10.1016/j.placenta.2012.10.007
2013 Zhang,S, Wyss,O, MacLaughlin,S, Walker,S, Kleemann,D, Suter,C, Morrison,J, Molloy,L, Cropley,J, Roberts,C et al, 2013, Maternal undernutrition during the first week after conception results in decreased expression of glucocorticoid receptor mRNA in the absence of GR exon 1₇ hypermethylation in the fetal pituitary in late gestation, Journal of Developmental Origins of Health and Disease, 4, 5, 391-401 10.1017/S2040174413000378
2013 McCowan,L, Thompson,J, Taylor,R, North,R, Poston,L, Baker,P, Myers,J, Roberts,C, Dekker,G, Simpson,N et al, 2013, Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort, PLoS One, 8, 8, 1-12 10.1371/journal.pone.0070917
2013 Andraweera,P, Dekker,G, Dissanayake,V, Bianco-Miotto,T, Jayasekara,R, Roberts,C, 2013, Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka, The Journal of Maternal - Fetal & Neonatal Medicine, 26, 5, 532-536 10.3109/14767058.2012.743520
2013 Zhou,A, Dekker,G, Lumbers,E, Leemaqz,S, Thompson,S, Heinemann,G, McCowan,L, Roberts,C, 2013, The association of maternal ACE A11860G with small for gestational age babies is modulated by the environment and by fetal sex: a multicentre prospective case–control study, Molecular Human Reproduction, 19, 9, 618-627 10.1093/molehr/gat029
2013 van der Graaf,A, Zeeman,G, Groen,H, Roberts,C, Dekker,G, 2013, Non-invasive assessment of maternal hemodynamics in early pregnancy, Pregnancy Hypertension, 3, 4, 261-269 10.1016/j.preghy.2013.07.005
2013 Lie,S, Morrison,J, Wyss,O, Ozanne,S, Zhang,S, Walker,S, Kleemann,D, MacLaughlin,S, Roberts,C, McMillen,I et al, 2013, Impact of embryo number and periconceptional undernutrition on factors regulating adipogenesis, lipogenesis, and metabolism in adipose tissue in the sheep fetus, American Journal of Physiology-Endocrinology and Metabolism, 305, 8, 931-941 10.1152/ajpendo.00180.2013
2013 Blankley,R, Fisher,C, Westwood,M, North,R, Baker,P, Walker,M, Williamson,A, Whetton,A, Lin,W, McCowan,L et al, 2013, A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia, Molecular and Cellular Proteomics, 12, 11, 3148-3159 10.1074/mcp.M112.026872
2013 Furness,D, Fenech,M, Dekker,G, Khong,T, Roberts,C, Hague,W, 2013, Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome, Maternal and Child Nutrition, 9, 2, 155-166 10.1111/j.1740-8709.2011.00364.x
2013 Xiang,R, Ghani Poor Samami,M, Johns,W, Eindorf,T, Rutley,D, Kruk,Z, Fitzsimmons,C, Thomsen,D, Roberts,C, Burns,B et al, 2013, Maternal and paternal genomes differentially affect myofibre characteristics and muscle weights of bovine fetuses at midgestation, PLoS One, 8, 1, 1-15 10.1371/journal.pone.0053402
2013 Lie,S, Sim,S, McMillen,I, Wyss,O, MacLaughlin,S, Kleemann,D, Walker,S, Roberts,C, Morrison,J, 2013, Maternal undernutrition around the time of conception and embryo number each impact on the abundance of key regulators of cardiac growth and metabolism in the fetal sheep heart, Journal of Developmental Origins of Health and Disease, 4, 5, 377-390 10.1017/S2040174413000354
2013 McCarthy,F, O'Keeffe,L, Khashan,A, North,R, Poston,L, McCowan,L, Baker,P, Dekker,G, Roberts,C, Walker,J et al, 2013, Association between maternal alcohol consumption in early pregnancy and pregnancy outcomes, Obstetrics and Gynecology, 122, 4, 830-837 10.1097/AOG.0b013e3182a6b226
2012 Andraweera,P, Dekker,G, Thompson,S, Roberts,C, 2012, Single-nucleotide polymorphisms in the KDR gene in pregnancies complicated by gestational hypertensive disorders and small-for-gestational-age infants, Reproductive Sciences, 19, 5, 547-554 10.1177/1933719111428520
2012 Andraweera,P, Dekker,G, North,R, Thompson,S, McCowan,L, Roberts,C, 2012, A functional variant in ANGPT1 and the risk of pregnancies with hypertensive disorders and small-for-gestational age infants, Molecular Human Reproduction, 18, 6, 325-332 10.1093/molehr/gar081
2012 Andraweera,P, Dekker,G, Roberts,C, 2012, The vascular endothelial growth factor family in adverse pregnancy outcomes, Human Reproduction Update, 18, 4, 436-457 10.1093/humupd/dms011
2012 Highet,A, Zhang,V, Heinemann,G, Roberts,C, 2012, Use of Matrigel in culture affects cell phenotype and gene expression in the first trimester trophoblast cell line HTR8/SVneo, Placenta, 33, 7, 586-588 10.1016/j.placenta.2012.04.003
2012 Soo,P, Hiscock,J, Botting,K, Roberts,C, Davey,A, Morrison,J, 2012, Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation, Reproductive Toxicology, 33, 3, 374-381 10.1016/j.reprotox.2012.01.013
2012 Gatford,K, Smits,R, Collins,C, De Blasio,M, Roberts,C, Nottle,M, Van Wettere,W, Kind,K, Owens,J, 2012, Maternal low-dose porcine somatotropin treatment in late gestation increases progeny weight at birth and weaning in sows but not in gilts, Journal of Animal Science, 90, 5, 1428-1435 10.2527/jas.2011-4227
2012 Dekker,G, Leemaqz,S, North,R, McCowan,L, Simpson,N, Roberts,C, 2012, Risk factors for preterm birth in an international prospective cohort of nulliparous women, PLoS One, 7, 7, 1-9 10.1371/journal.pone.0039154
2012 Andraweera,P, Dekker,G, Laurence,J, Roberts,C, 2012, Placental expression of VEGF family mRNA in adverse pregnancy outcomes, Placenta, 33, 6, 467-472 10.1016/j.placenta.2012.02.013
2012 Buckberry,S, Bianco-Miotto,T, Hiendleder,S, Roberts,C, 2012, Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity, PLoS One, 7, 12, 1-11 10.1371/journal.pone.0051210
2012 Furness,D, Yasin,N, Dekker,G, Thompson,S, Roberts,C, 2012, Maternal red blood cell folate concentration at 10-12 weeks gestation and pregnancy outcome, The Journal of Maternal - Fetal & Neonatal Medicine, 25, 8, 1423-1427 10.3109/14767058.2011.636463
2012 Tung,E, Roberts,C, Heinemann,G, De Blasio,M, Kind,K, Van Wettere,W, Owens,J, Gatford,K, 2012, Increased placental nutrient transporter expression at mid-gestation after maternal growth hormone treatment in pigs: A placental mechanism for increased fetal growth, Biology of Reproduction, online, 5, 1-17 10.1095/biolreprod.112.100222
2012 Andraweera,P, Dekker,G, Thompson,S, North,R, McCowan,L, Roberts,C, 2012, The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth, Molecular Human Reproduction, 18, 9, 459-465 10.1093/molehr/gas016
2011 van der Graaf,AM, Zeeman,GG, Groen,H, Lumbers,ER, Roberts,C, Dekker,GA, 2011, O15. Non-invasive assessment of hemodynamics in early pregnancy., Pregnancy hypertension, 1, 3-4, 264- 10.1016/j.preghy.2011.08.047
2011 Carty,DM, Siwy,J, Brennand,JE, Zuerbig,P, Mullen,W, Franke,J, McCulloch,JW, Roberts,CT, North,RA, Chappell,LC et al, 2011, Urinary Proteomics for Prediction of Preeclampsia (vol 57, pg 561, 2011), HYPERTENSION, 58, 4, E32-E32 10.1161/HYP.0b013e31823163c4
2011 Sferruzzi-Perri,A, Owens,J, Pringle,K, Roberts,C, 2011, The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth, Journal of Physiology-London, 589, 1, 7-20 10.1113/jphysiol.2010.198622
2011 Dekker,G, Robillard,P, Roberts,C, 2011, The etiology of preeclampsia: The role of the father, Journal of Reproductive Immunology, 89, 2, 126-132 10.1016/j.jri.2010.12.010
2011 McCowan,L, North,R, Kho,E, Black,M, Chan,E, Dekker,G, Poston,L, Taylor,R, Roberts,C, 2011, Paternal contribution to small for gestational age babies: a mulitcenter propective study, Obesity, 19, 5, 1035-1039 10.1038/oby.2010.279
2011 Horgan,R, Broadhurst,D, Walsh,S, Dunn,W, Brown,M, Roberts,C, North,R, McCowan,L, Kell,D, Baker,P et al, 2011, Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy, Journal of Proteome Research, 10, 8, 3660-3673 10.1021/pr2002897
2011 Andraweera,P, Dekker,G, Thompson,S, Nowak,R, Zhang,V, McCowan,L, North,R, Roberts,C, 2011, Association of vascular endothelial growth factor +936 C/T single-nucleotide polymorphism with pregnancies complicated by small-for-gestational-age babies, Archives of Pediatrics & Adolescent Medicine, 165, 12, 1123-1130 10.1001/archpediatrics.2011.796
2011 Furness,D, Dekker,G, Roberts,C, 2011, DNA damage and health in pregnancy, Journal of Reproductive Immunology, 89, 2, 153-162 10.1016/j.jri.2011.02.004
2011 O'Connell,B, Moritz,K, Roberts,C, Walker,D, Dickinson,H, 2011, The placental response to excess maternal glucocorticoid exposure differs between the male and female conceptus in spiny mice, Biology of Reproduction, 85, 5, 1040-1047 10.1095/biolreprod.111.093369
2011 Andraweera,P, Dekker,G, Thompson,S, North,R, McCowan,L, Roberts,C, 2011, A functional variant in the thrombospondin-1 gene and the risk of small for gestational age infants, Journal of Thrombosis and Haemostasis, 9, 11, 2221-2228 10.1111/j.1538-7836.2011.04494.x
2011 Carty,D, Siwy,J, Brennand,J, Zurbig,P, Mullen,W, Franke,J, McCulloch,J, Roberts,C, North,R, Chappell,L et al, 2011, Urinary proteomics for prediction of preeclampsia, Hypertension, 57, 3, 561-569 10.1161/HYPERTENSIONAHA.110.164285
2010 McCowan,L, Roberts,C, Dekker,G, Taylor,R, Chan,E, Kenny,L, Baker,P, Moss-Morris,R, Chappell,L, North,R et al, 2010, Risk factors for small-for-gestational-age infants by customised birthweight centiles: data from an international prospective cohort study, BJOG, 117, 13, 1599-1607 10.1111/j.1471-0528.2010.02737.x
2010 Ng,H, Novakovic,B, Hiendleder,S, Craig,J, Roberts,C, Saffery,R, 2010, Distinct patterns of gene-specific methylation in mammalian placentas: Implications for placental evolution and function, Placenta, 31, 4, 259-268 10.1016/j.placenta.2010.01.009
2010 McArdle,A, Maduwegedera,D, Moritz,K, Flower,R, Denton,K, Roberts,C, 2010, Chronic maternal hypertension affects placental gene expression and differentiation in rabbits, Journal of Hypertension, 28, 5, 959-968 10.1097/HJH.0b013e3283369f1e
2010 McArdle,A, Roberts,C, Maduwegedera,D, Flower,R, Denton,K, 2010, Chronic maternal hypertension characterized by renal dysfunction is associated with reduced placental blood flow during late gestation in rabbits, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 298, 4, R1043-R1049 10.1152/ajpregu.00202.2009
2010 Roberts,C, 2010, IFPA Award in Placentology Lecture: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health, Placenta, 24, SUPPL., S47-S53 10.1016/j.placenta.2010.01.001
2010 Roberts,C, 2010, Preface, Placenta, 31, SUPPL., S2-S3 10.1016/j.placenta.2009.12.004
2010 Novakovic,B, Wong,N, Sibson,M, Ng,H, Morley,R, Manuelpillai,U, Down,T, Rakyan,V, Beck,S, Hiendleder,S et al, 2010, DNA methylation-mediated Down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta, Journal of Biological Chemistry, 285, 13, 9583-9593 10.1074/jbc.M109.064956
2010 Pringle,K, Kind,K, Sferruzzi-Perri,A, Thompson,J, Roberts,C, 2010, Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy, Human Reproduction Update, 16, 4, 415-431 10.1093/humupd/dmp046
2010 Gatford,K, Smits,R, Collins,C, Argent,C, De Blasio,M, Roberts,C, Nottle,M, Kind,K, Owens,J, 2010, Maternal responses to daily maternal porcine somatotropin injections during early-mid pregnancy or early-late pregnancy in sows and gilts, Journal of Animal Science, 88, 4, 1365-1378 10.2527/jas.2009-2265
2010 Kenny,L, Broadhurst,D, Dunn,W, Brown,M, North,R, McCowan,L, Roberts,C, Cooper,G, Kell,D, Baker,P et al, 2010, Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers, Hypertension, 56, 4, 741-749 10.1161/HYPERTENSIONAHA.110.157297
2010 Roberts,C, 2010, Predicting Pregnancy and Fertility Outcomes with Genomics and Epigenomics, AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 50, 31-31
2010 Lash,G, Burton,G, Chamley,L, Clifton,V, Constancia,M, Crocker,I, Dantzer,V, Desoye,G, Drewlo,S, Hemmings,D et al, 2010, IFPA Meeting 2009 Workshops Report, Placenta, 31, Suppl, S4-S20 10.1016/j.placenta.2009.12.008
2009 McArdle,A, Denton,K, Maduwegedera,D, Moritz,K, Flower,R, Roberts,C, 2009, Ontogeny of placental structural development and expression of the renin–angiotensin system and 11β-HSD₂ genes in the rabbit, Placenta, 30, 7, 590-598 10.1016/j.placenta.2009.04.006
2009 Gatford,K, De Blasio,M, Roberts,C, Nottle,M, Kind,K, Van Wettere,W, Smits,R, Owens,J, 2009, Responses to maternal GH or ractopamine during early-mid pregnancy are similar in primiparous and multiparous pregnant pigs, Journal of Endocrinology, 203, 1, 143-154 10.1677/JOE-09-0131
2009 Lash,G, Ansari,T, Bischof,P, Burton,G, Chamley,L, Crocker,I, Dantzer,V, Desoye,G, Drewlo,S, Fazleabas,A et al, 2009, IFPA meeting 2008 workshops report, Placenta, 30, Suppl A, S4-S14 10.1016/j.placenta.2008.11.014
2009 Kho,E, McCowan,L, North,R, Roberts,C, Chan,E, Black,M, Taylor,R, Dekker,G, 2009, Duration of sexual relationship and its effect on preeclampsia and small for gestational age perinatal outcome, Journal of Reproductive Immunology, 82, 1, 66-73 10.1016/j.jri.2009.04.011
2009 Sferruzzi-Perri,A, Macpherson,A, Roberts,C, Robertson,S, 2009, Csf2 Null Mutation Alters Placental Gene Expression and Trophoblast Glycogen Cell and Giant Cell Abundance in Mice, Biology of Reproduction, 81, 1, 207-221 10.1095/biolreprod.108.073312
2008 Sferruzzi-Perri,A, Owens,J, Standen,P, Roberts,C, 2008, Maternal insulin-like growth factor-II promotes placental functional development via the type 2 IGF receptor in the guinea pig, Placenta, 29, 4, 347-355 10.1016/j.placenta.2008.01.009
2008 Sferruzzi-Perri,A, Macpherson,A, Roberts,C, Robertson,S, 2008, Granulocyte-macrophage colony-stimulating factor (GM-CSF) regulates junctional zone trophoblast lineage commitment and thereby placental morphogenesis and function, Placenta, 29, 8, A96-A96 10.1016/j.placenta.2008.06.002
2008 Roberts,C, Owens,J, Sferruzzi-Perri,A, 2008, Distinct Actions of Insulin-Like Growth Factors (IGFs) on Placental Development and Fetal Growth: Lessons from Mice and Guinea Pigs., Placenta, 29, Supplement 1, 42-47 10.1016/j.placenta.2007.12.002
2007 Sferruzzi-Perri,A, Owens,J, Standen,P, Taylor,R, Robinson,J, Roberts,C, 2007, Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation, Endocrinology, 148, 9, 4362-4370 10.1210/en.2007-0411
2007 Pringle,K, Roberts,C, 2007, New light on early post-implantation pregnancy in the mouse: Roles for insulin-like growth factor-II (IGF-II)?, Placenta, 28, 4, 286-297 10.1016/j.placenta.2006.04.006
2007 McArdle,A, Mortiz,K, Maduwegedera,D, Roberts,C, Flower,R, Wintour,E, Denton,K, 2007, The effect of chronic hypertension on placental renin-angiotenisn system and 11 beta-hydroxysteriod dehydrogenase type 2 gene expressions during mid and late-gestation in rabbits, EARLY HUMAN DEVELOPMENT, 83, S145-S145 10.1016/S0378-3782(07)70392-4
2007 Sferruzzi-Perri,A, Owens,J, Standen,P, Taylor,R, Heinemann,G, Robinson,J, Roberts,C, 2007, Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term, American Journal of Physiology-Endocrinology and Metabolism, 292, 3, E668-E676 10.1152/ajpendo.00320.2006
2007 Roberts,CT, Standen,P, Sferruzzi-Perri,AN, Owens,JA, Kumarasamy,V, Lumbers,ER, 2007, P2-61 novel but distinct interactions of insulin-like growth factors (IGFs) with the placental renin-angiotensin system in early gestation in guinea pigs, Early Human Development, 83, Suppl. 1, S146-S146 10.1016/S0378-3782(07)70394-8
2007 Sferruzzi-Perri,A, Owens,J, Standen,R, Roberts,C, 2007, Insulin-like growth factor-II promotes placental functional development and fetal growth via the type 2 IGF receptor, EARLY HUMAN DEVELOPMENT, 83, S61-S61 10.1016/S0378-3782(07)70100-7
2007 Pringle,K, Kind,K, Thompson,J, Roberts,C, 2007, Complex interactions between hypoxia inducible factors, insulin-like growth Factor-II and oxygen in early murine trophoblasts, Placenta, 28, 11-12, 1147-1157 10.1016/j.placenta.2007.05.009
2007 Roberts,C, Ng,R, Heinemann,G, 2007, IGF-II synergises with low oxygen to promote placental trophoblast invasion via the IGF2R/uPA/plasminogen complex, EARLY HUMAN DEVELOPMENT, 83, S51-S51 10.1016/S0378-3782(07)70067-1
2007 Fletcher,C, Roberts,C, Hartwich,K, Walker,S, McMillen,I, 2007, Somatic cell nuclear transfer in the sheep induces placental defects that likely precede fetal demise, Reproduction, 133, 1, 243-255 10.1530/rep.1.01203
2006 Sferruzzi-Perri,A, Owens,J, Pringle,K, Robinson,J, Roberts,C, 2006, Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth, Endocrinology, 147, 7, 3344-3355 10.1210/en.2005-1328
2006 Ferguson-Smith,A, Moore,T, Detmar,J, Lewis,A, Hemberger,J, Jammes,H, Kelsey,G, Roberts,C, Constancia,M, 2006, Epigenetics and imprinting of the trophoblast - A workshop report, Placenta, 27, SUPPL., S122-S126 10.1016/j.placenta.2006.01.015
2006 Inglis,D, Lane,M, Roberts,C, Kelley,R, Edwards,L, Thompson,J, Kind,K, 2006, Effect of culturing mouse embryos under different oxygen concentrations on subsequent fetal and placental development, Journal of Physiology-London, 572, 1, 87-96 10.1113/jphysiol.2005.102681
2006 Ferguson-Smith,A, Moore,T, Detmar,J, Lewis,A, Hemberger,M, Jammes,H, Kelsey,G, Roberts,C, Jones,H, Constancia,M et al, 2006, Erratum to "Epigenetics and Imprinting of the Trophoblast - A Workshop Report" [Placenta 27, supplement A, Trophoblast Research, Vol. 20 S122-S126] (DOI:10.1016/j.placenta.2006.01.015), Placenta, 27, 9-10, 1036- 10.1016/j.placenta.2006.06.004
2005 MacLaughlin,S, Walker,S, Roberts,C, Kleemann,D, McMillen,I, 2005, Periconceptional nutrition and the relationship between maternal body weight changes in the periconceptional period and feto-placental growth in the sheep, Journal of Physiology-London, 565, 1, 111-124 10.1113/jphysiol.2005.084996
2005 Sjoblom,C, Roberts,C, Wikland,M, Robertson,S, 2005, Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis, Endocrinology, 146, 5, 2142-2153 10.1210/en.2004-1260
2005 Sferruzzi-Perrio,A, Owens,J, Pringle,K, Robinson,J, Roberts,C, 2005, Exogenous insulin like growth factors in early pregnancy act via different mechanisms to promote fetal growth, PLACENTA, 26, 8-9, A20-A20
2005 Grant,P, Kind,K, Roberts,C, Sohlstrom,A, Owens,P, Owens,J, 2005, Late pregnancy increases hepatic expression of insulin-like growth factor-I in well nourished guinea pigs, Growth Hormone & IGF Research, 15, 2, 165-171 10.1016/j.ghir.2005.01.002
2005 Sferruzzi-Perri,A, Robinson,J, Roberts,C, 2005, Insulin like growth factor-II mediates the effect of hypoxia on human cytotrophoblast outgrowth, PLACENTA, 26, 8-9, A61-A61
2005 Muhlhausler,B, Adam,C, Marrocco,E, Findlay,P, Roberts,C, McFarlane,J, Kauter,K, McMillen,I, 2005, Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation, Journal of Physiology-London, 565, 1, 185-195 10.1113/jphysiol.2004.079079
2005 Kind,K, Roberts,C, Sohlstrom,A, Katsman,A, Clifton,P, Robinson,J, Owens,J, 2005, Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 288, 1, R119-R126 10.1152/ajpregu.00360.2004
2004 Gude,N, Roberts,C, Kalionis,B, King,R, 2004, Growth and function of the normal human placenta, Thrombosis Research, 114, 5-6 SPEC. ISS., 397-407 10.1016/j.thromres.2004.06.038
2004 Carter,A, Hills,F, O'Gorman,D, Roberts,C, Sooranna,S, Watson,C, Westwood,M, 2004, The insulin-like growth factor system in mammalian pregnancy - workshop report, Placenta, 25, sup A, S53-S56 10.1016/j.placenta.2004.01.019
2004 Bromfield,J, Roberts,C, Robertson,S, 2004, Seminal plasma programs uterine receptivity and pregnancy outcome., BIOLOGY OF REPRODUCTION, 94-94
2004 Robertson,S, Roberts,C, van Beijering,E, Pensa,K, Sheng,Y, Shi,T, Krilis,S, 2004, Effect of β₂‐glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody‐mediated pregnancy pathology in mice, Molecular Human Reproduction, 10, 6, 409-416 10.1093/molehr/gah058
2004 White,C, Johansson,M, Roberts,C, Ramsay,A, Robertson,S, 2004, Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice, Biology of Reproduction, 70, 1, 123-131 10.1095/biolreprod.103.018754
2003 Muhlhausler,B, Roberts,C, Yuen,B, Marrocco,E, Budge,H, Symonds,M, McFarlane,J, Kauter,K, Stagg,P, Pearse,J et al, 2003, Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy, Endocrinology, 144, 11, 4947-4954 10.1210/en.2003-0555
2003 Roberts,C, White,C, Wiemer,N, Ramsay,A, Robertson,S, 2003, Altered placental development in interleukin-10 null mutant mice, Placenta, 24, SUPPL. A, S94-S99 10.1053/plac.2002.0949
2003 Yuen,B, Owens,P, Muhlhausler,B, Roberts,C, Symonds,M, Keisler,D, McFarlane,J, Kauter,K, Evens,Y, McMillen,I et al, 2003, Leptin alters the structural and functional characteristics of adipose tissue before birth, FASEB Journal, 17, 6, www 1-www 22 10.1096/fj.02-0756fje
2003 Kind,K, Clifton,P, Grant,P, Owens,P, Sohlstrom,A, Roberts,C, Robinson,J, Owens,J, 2003, Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 284, 1, R140-R152 10.1152/ajpregu.00587.2001
2003 Roberts,C, Owens,J, Carter,A, Harding,J, Austgulen,R, Wlodek,M, 2003, Insulin-like growth factors and foetal programming - a workshop report, Placenta, 24, 17, S72-S75 10.1053/plac.2002.0935
2002 Muhlhausler,B, Roberts,C, McFarlane,J, Kauter,K, McMillen,I, 2002, Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements, Biology of Reproduction, 67, 2, 493-499 10.1095/biolreprod67.2.493
2002 Roberts,C, Kind,K, Earl,R, Grant,P, Robinson,J, Sohlstrom,A, Owens,P, Owens,J, 2002, Circulating insulin-like growth factor (IGF)-1 and IGF binding proteins -1 and -3 and placental development in the guinea-pig, Placenta, 23, 10, 763-770 10.1053/plac.2002.0849
2002 Thompson,J, Kind,K, Roberts,C, Robertson,S, Robinson,J, 2002, Epigenetic risks related to assisted reproductive technologies - Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?, Human Reproduction, 17, 11, 2783-2786 10.1093/humrep/17.11.2783
2001 Roberts,C, Sohlstrom,A, Kind,K, Earl,R, Khong,T, Robinson,J, Owens,P, Owens,J, 2001, Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig, Placenta, 22, 02-Mar, 177-185 10.1053/plac.2000.0602
2001 Roberts,C, Sohlstrom,A, Kind,K, Grant,P, Earl,R, Robinson,J, Khong,T, Owens,P, Owens,J, 2001, Altered placental structure induced by maternal food restriction in guinea pigs: A role for circulating IGF-II and IGFBP-2 in the mother?, Placenta, 22, Suppl A, S77-S82 10.1053/plac.2001.0643
1999 Robertson,S, Roberts,C, Farr,K, Dunn,A, Seamark,R, 1999, Fertility impairment in granulocyte-macrophage colony-stimulating factor deficient mice, Biology of Reproduction, 60, 2, 251-261 10.1095/biolreprod60.2.251
1998 Sohlstrom,A, Katsman,A, Kind,K, Roberts,C, Owens,P, Robinson,J, Owens,J, 1998, Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig, American Journal of Physiology, Endocrinology and Metabolism, 274, 37, E410-E416
1997 Roberts,C, Selwood,L, Leigh,C, Breed,W, 1997, Anitserum to the egg coats of the fat-tailed dunnart (Marsuplia. Dasyuridae) cross-reacts with egg coats of other marsupial and eutherian species, Journal of Experimental Zoology Part A: Comparative Experimental Biology, 278, 3, 133-139 10.1002/(SICI)1097-010X(19970615)278:3<133::AID-JEZ2>3.0.CO;2-P
1997 Wood,P, Andrew,L, Daniels,C, Orgieg,S, Roberts,C, 1997, Autonomic control of the pulmonary surfactant system and lung compliance in the lizard, Physiological Zoology, 70, 4, 444-455 10.1086/515847
1996 Roberts,C, Breed,W, 1996, The marsupial shell membrane: an ultrastructural and immunogold localization study, Cell and Tissue Research, 284, 1, 99-110 10.1007/s004410050570
1996 Roberts,C, Breed,W, 1996, Changes in structure of the trophectoderm of a marsupial in Mid-pregnancy up to the time of implantation, Reproduction, Fertility and Development, 8, 4, 797-802 10.1071/RD9960797
1996 Roberts,C, Breed,W, 1996, Variation in ultrastructure of mucoid coat and shell membrane secretion of a dasyurid marsupial, Reproduction, Fertility and Development, 8, 4, 645-648 10.1071/RD9960645
1994 Roberts,C, Breed,W, 1994, Placentation in the dasyurid marsupial, Sminthopsis crassicaudata, the fat-tailed dunnart, and notes on placentation of the didelphid Monodelphis domestica, Journal of Reproduction and Fertility, 100, 1, 105-113 10.1530/jrf.0.1000105
1994 Roberts,C, Breed,W, 1994, Embryonic‐maternal cell interactions at implantation in the fat‐tailed dunnart, a dasyurid marsupial, The Anatomical Record, 240, 1, 59-76 10.1002/ar.1092400107
1994 Roberts,C, Breed,W, Mayrhofer,G, 1994, Origin of the oocyte shell membrane of a dasyurid marsupial: An immunohistochemical study, Journal of Experimental Zoology, 270, 3, 321-331 10.1002/jez.1402700311

Conference Papers

Date Citation
2016 Wilson,R, Leemaqz,S, Goh,Z, McAninch,D, Jankovic-Karasoulos,T, Bianco-Miotto,T, Roberts,C, 2016, ZINC DEFICIENCY ALTERS PLACENTAL DEVELOPMENT AND MATERNAL HEMODYNAMICS CONTRIBUTING TO FETAL GROWTH RESTRICTION IN MICE, Meeting of the International-Federation-of-Placenta-Associations (IFPA) - Placenta-Back to the Basics, Portland, OR 10.1016/j.placenta.2016.06.069
2015 Barbaux,S, Erwich,J, Favaron,P, Gil,S, Gallot,D, Golos,T, Gonzalez-Bulnes,A, Guibourdenche,J, Heazell,A, Jansson,T et al, 2015, IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction, Joint Meeting of the International-Federation-of-Placenta-Associations (IFPA) and European-Placenta-Group (EPG), Paris, FRANCE 10.1016/j.placenta.2015.01.196
2015 Bianco-Miotto,T, Lopez,CR, Leemaqz,S, Buckberry,S, McCullough,D, Zhuang,Z, Dekker,G, Wilkinson,M, Roberts,C, 2015, DNA METHYLATION BIOMARKERS FOR PREDICTING PREGNANCY COMPLICATIONS 10.1016/j.placenta.2015.07.302
2014 Leemaqz,S, Dekker,G, McCowan,L, Roberts,C, 2014, Prediction model for spontaneous preterm at 15 weeks of gestation, 34th Annual Scientific Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine, New Orleans, LA
2014 Verburg,P, Tucker,G, Scheil,W, Roberts,C, Dekker,G, 2014, Seasonality of gestational diabetes mellitus based on date of conception in South Australia-a retrospective population study 2006-2011, 34th Annual Scientific Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine, New Orleans, LA
2013 Leemaqz,S, Dekker,G, Roberts,C, 2013, Tiered prediction system for preeclampsia: an integrative application of multiple models, International Congress on Modelling and Simulation, Adelaide, South Australia
2012 Andraweera,PH, Dekker,, Thompson,SD, Zhang,VJ, Roberts,CT, 2012, Association of maternal, paternal and fetal single nucleotide polymorphisms in vascular endothelial growth factor family genes with preeclampsia, 17th World Congress of the Society for the Study of Hypertension in Pregnancy, Melbourne, Australia
2012 Andraweera,PH, Dekker,, Dissanayake,VHW, Jayasekara,RW, Roberts,CT, 2012, A candidate gene association study on preeclampsia in Sinhalese women, Human Genome Meeting, Sydney, Australia
2012 Andraweera,PH, Dekker,, Dissanayaye,VHW, Jayasekara,RW, Roberts,CT, 2012, Candidate gene association study on recurrent pregnancy loss in a Sinhalese population from in Sri Lanka, Human Genome Meeting, Sydney, Australia
2012 Lee,S, Lee,S, Dekker,G, Roberts,C, 2012, Multivariate visual clustering of single nucleotide polymorphisms and clinical predictors using Chernoff faces, Annual Applied Statistics Education and Research Collaboration, Wollongong, New South Wales
2011 Dickinson,H, O'Connell,B, Moritz,K, Roberts,C, Walker,D, 2011, THE PLACENTAL RESPONSE TO EXCESS MATERNAL GLUCOCORTICOID EXPOSURE DIFFERS BETWEEN THE MALE AND FEMALE CONCEPTUS, Meeting of the International-Federation-of-Placenta-Associations (IFPA), Geilo, NORWAY
2011 Everard,C, Khashan,A, Kenny,L, North,R, Howard,L, Dekker,G, Roberts,C, McCowan,L, 2011, Prospective cohort study to examine the association between perceived maternal stress and subsequent pregnancy outcomes, 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine, Chicago, IL 10.1016/j.ajog.2010.10.568
2011 Zhou,A, Dekker,G, Lumbers,E, Heinemann,G, North,R, McCowan,L, Roberts,C, 2011, ASSOCIATION OF THE ACE A11860G SINGLE NUCLEOTIDE POLYMORPHISM (SNP) AND FETAL SEX IN SMALL FOR GESTATIONAL AGE (SGA) PREGNANCY, Meeting of the International-Federation-of-Placenta-Associations (IFPA), Geilo, NORWAY
2011 Andraweera,P, Dekker,, Thompson,S, North,R, McCowan,L, Roberts,C, 2011, Single nucleotide polymorphisms in angiogenesis regulating genes and the risk of preeclampsia and small for gestational age birth, 12th International Congress of Human Genetics, Montreal, Canada
2010 Andraweera,P, Furness,D, Thompson,S, Nowak,R, Dissanayake,V, Jayasekara,R, Dekker,G, Roberts,C, 2010, Single nucleotide polymorphisms in genes regulating inflammation and the risk of recurrent pregnancy loss in a Sinhalese population from Sri Lanka, 11th International Congress of Reproductive Immunology, Palm Grove, AUSTRALIA 10.1016/j.jri.2010.06.103
2010 Andraweera,P, Nowak,R, Thompson,S, Furness,D, Dissanayake,V, Jayasekara,R, Dekker,G, Roberts,C, 2010, Single nucleotide polymorphisms in genes modulating inflammation and the risk of preeclampsia in a Sinhalese population from Sri Lanka, 11th International Congress of Reproductive Immunology, Palm Grove, AUSTRALIA 10.1016/j.jri.2010.06.135
2010 O'Connell,BA, Roberts,CT, Moritz,KM, Walker,DW, Dickinson,H, 2010, GENE EXPRESSION IN THE PLACENTA OF A PRECOCIAL SPECIES - THE SPINY MOUSE, International-Federation-of-Placental-Associations Meeting 2010, Santiago, CHILE
2010 Andraweera,PH, Dekker,, Thompson,SD, Dissanayake,VHW, Jayasekara,RW, Roberts,CT, 2010, Insulin like growth factor family genes and the risk of preeclampsia in a Sinhalese population from Sri Lanka, 17th World Congress of the Society for the Study of Hypertension in Pregnancy, Melbourne, Australia
2010 Dekker,G, Roberts,C, 2010, Preeclampsia and intra-uterine growth restriction: the role of the father, 11th International Congress of Reproductive Immunology, Palm Grove, AUSTRALIA 10.1016/j.jri.2010.06.007
2010 O'Connell,BA, Moritz,KM, Roberts,CT, Walker,DW, Dickinson,H, 2010, MATERNAL GLUCOCORTICOID EXPOSURE ALTERS PLACENTAL GENE EXPRESSION DIFFERENTLY, DEPENDING ON THE SEX OF THE FETUS, International-Federation-of-Placental-Associations Meeting 2010, Santiago, CHILE
2010 Kong,W, Nowak,R, Roberts,C, Owens,J, 2010, MICRORNAS ARE DIFFERENTIALLY EXPRESSED IN FIRST TRIMESTER HUMAN PLACENTA, International-Federation-of-Placental-Associations Meeting 2010, Santiago, CHILE
2010 Roberts,CT, Thompson,S, Furness,D, Lee,S, Anderson,P, Morris,H, Dekker,G, 2010, Season, vitamin D-related genes and maternal circulating 25OH vitamin D3 associate with pregnancy complications in an Australian population, 11th International Congress of Reproductive Immunology, Palm Grove, AUSTRALIA 10.1016/j.jri.2010.06.141
2010 Andraweera,PH, Dekker,, Thompson,SD, McCowan,LME, North,RA, Roberts,CT, 2010, Association of single nucleotide polymorphism in the vascular endothelial growth factor gene with small for gestational age birth, 17th World Congress of the Society for the Study of Hypertension in Pregnancy, Melbourne, Australia
2010 Everard,CM, Carrol,GO, Khashan,A, McCowan,L, North,R, Dekker,G, Roberts,C, Howard,L, Kenny,LC, 2010, Prospective Cohort Study To Examine the Association between Maternal Anxiety and Depression and Subsequent Pregnancy Outcomes., 57th Annual Meeting of the Society-for-Gynecologic-Investigation, Orlando, FL
2010 Roberts,C, Thompson,S, Furness,D, Lee,S, Anderson,P, Morris,H, 2010, INTERACTIONS BETWEEN VITAMIN D RELATED GENES AND MATERNAL CIRCULATING 25OH VITAMIN D3 IN PREGNANCY COMPLICATIONS IN AN AUSTRALIAN POPULATION, International-Federation-of-Placental-Associations Meeting 2010, Santiago, CHILE
2010 Andraweera,PH, Nowak,RC, Thompson,SD, Dissanayake,VHW, Jayasekara,RW, Roberts,CT, 2010, Association of single nucleotide polymorphisms in cytokine genes with preeclampsia in a Sinhalese population from Sri Lanka, 17th World Congress of the Society for the Study of Hypertension in Pregnancy, Melbourne, Australia
2009 Kho,EM, McCowan,LM, Roberts,C, Chan,E, Black,MA, North,RA, Dekker,G, 2009, A Short Duration of Sexual Relationship Is Associated with a Doubling of the Risk of Preeclampsia, 56th Annual Meeting of the Society-for-Gynecological-Investigation, Glasgow, SCOTLAND
2009 McCowan,L, Chan,E, Taylor,R, Stewart,A, Roberts,C, Dekker,G, North,R, 2009, Risk factors for infants small for gestational age by customized birthweight centiles, 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine, Chicago, IL
2009 Furness,D, Thompson,S, Nowak,R, Zhang,V, McCormack,C, Dekker,G, Roberts,C, 2009, DNA damage, DNA repair and metabolic detoxification enzyme polymorphisms are associated with adverse pregnancy outcomes, 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine, Chicago, IL
2009 Roberts,C, Thompson,S, Nowak,R, Zhang,V, Furness,D, Dekker,G, 2009, Insulin-like growth factor family related single nucleotide polymorphisms (SNPS) in mother, father and fetus are associated with adverse pregnancy outcomes, 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine, Chicago, IL
2009 Andraweera,PH, Thompson,SD, Nowak,RC, Zhang,VJ, Dekker,, Roberts,CT, 2009, Single nucleotide polymorphisms in angiogenesis regulating genes are associated with pregnancy complications, Annual Conference of the International Federation of Placental Associations (IFPA, Adelaide, Australia
2009 Roberts,C, Thompson,S, Furness,D, Anderson,P, Morris,H, Dekker,G, 2009, Season and vitamin D related genes but not maternal circulating 25OH vitamin D associate with pregnancy complications in an Australian population, 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine, Chicago, IL
2009 Andraweera,P, Thompson,S, Zhang,V, Nowak,R, Dekker,G, Roberts,C, 2009, Maternal, paternal and fetal single nucleotide polymorphisms in vascular endothelial growth factor family genes associate with pregnancy complications, 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine, Chicago, IL
2009 Kho,EM, McCowan,LM, Roberts,C, Chan,E, Black,MA, North,RA, Dekker,GA, 2009, Paternal Truncal Obesity Modifies the Risk of Preeclampsia and Small for Gestational Age Babies, 56th Annual Meeting of the Society-for-Gynecological-Investigation, Glasgow, SCOTLAND
2008 Roberts,C, Thompson,S, Zhou,J, Nowak,R, Dekker,G, 2008, Placental IGF2 genotype and pregnancy success, 14th Meeting of the International-Federation-of-Placental-Associations/12th Meeting of the European-Placenta-Group (IFPA/EPG), Seggau Castle, AUSTRIA
2008 NicArdle,AM, Roberts,CT, Moriz,K, Maduwegedera,D, Flower,RL, Wintour,EM, Denton,KM, 2008, Chronic maternal hypertension affects placental gene expression, blood flow and structure in rabbits, 14th Meeting of the International-Federation-of-Placental-Associations/12th Meeting of the European-Placenta-Group (IFPA/EPG), Seggau Castle, AUSTRIA
2008 Nowak,R, Thompson,S, Zhang,J, Dekker,G, Roberts,C, 2008, Influence of paternal genotype on pregnancy outcome, 14th Meeting of the International-Federation-of-Placental-Associations/12th Meeting of the European-Placenta-Group (IFPA/EPG), Seggau Castle, AUSTRIA
2007 Pringle,KG, Kind,KL, Thompson,JG, Roberts,CT, 2007, Oxygen and IGF-II interact in early murine trophoblasts, 13th International-Federation-of-Placenta-Association Meeting, Kingston, CANADA
2007 Gatford,K, De Blasio,M, Harland,M, Roberts,C, Heinemann,G, Nottle,M, Ashman,R, Kind,K, Van Wettere,W, Pain,S et al, 2007, Effects of maternal somatotropin injections or feeding ractopamine in early-mid pregnancy in gilts and sows -UTV-AC-8/05, Manipulating Pig Production XI, Brisbane
2007 McArdle,AM, Mortiz,K, Maduwegedera,D, Roberts,CT, Flower,RL, Wintour,EM, Denton,KM, 2007, The effect of chronic hypertension on the placental renin-angiotensin system and 11-beta-hydroxysteroid dehydrogenase gene expression during mid and late-gestation in rabbits, Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia, AUSTRALIA
2006 Lumbers,ER, Standen,P, Kumarasamy,V, Sferruzzi-Perri,AN, Taylor,R, Heinemann,G, Roberts,CT, 2006, Novel effects of insulin-like growth factor (IGF)-I and -II on placental renin in the guinea pig, 12th Meeting of the International-Federation-of-Placenta-Association, Kobe, JAPAN
2006 Roberts,C, Standen,P, Sferruzzi-Perri,A, Owens,J, Robinson,J, Taylor,R, Heinemann,G, 2006, Acute effects of endocrine insulin-like growth factor (IGF)-I and -II on the mother, fetus and placenta in the guinea pig, 12th Meeting of the International-Federation-of-Placenta-Association, Kobe, JAPAN
2005 Roberts,C, Sferruzzi-Perri,A, Kind,K, Robinson,J, Owens,J, 2005, Placental perturbations and pregnancy outcome: a common thread, Havenmeyer Foundation Monograph Series No. 17, Victoria, Canada
2005 MacLaughlin,SM, Walker,SK, Roberts,CT, Kleemann,DO, McMillen,IC, 2005, Periconceptional undernutrition alters the relationship between maternal body weight and fetoplacental growth in the sheep during early gestation., 52nd Annual Meeting of the Society-for-Gynecologic-Investigation, Los Angeles, CA
2004 Roberts,CT, Sferruzzi-Perri,AN, Grant,PA, Donaldson,AC, 2004, Placental differentiation is regulated by the interaction of IGF-II and latent TGF beta 1 with IGF2R under the influence of oxygen, Conference of the Placenta-Association-of-the-Americas/10th Meeting of the International-Federation-of-Placenta, Asilomar, CA

Conference Items

Date Citation
2017 Gatford,KL, Muhlhausler,BS, Sim,PS-L, Roberts,CT, Veldhuis,JD, Huang,L, Chen,C, 2017, Pulsatile GH profiles in the pregnant mouse reveal marked increases in circulating GH and GH secretion between early and mid-pregnancy
2016 Estrella,C, Kind,K, Ghanipoor-Samami,M, Javadmanesh,A, Roberts,C, Hiendleder,S, 2016, Polar overdominance and maternal genome effects in placenta drive heterosis in utero 10.2134/jas2016.94supplement449a
2015 Buckberry,S, Bianco-Miotto,T, Bent,S, Dekker,G, Roberts,C, 2015, INTEGRATIVE ANALYSIS OF PLACENTAL TRANSCRIPTOME ORGANIZATION REVEALS HIGHLY CONSERVED REGULATORY PROGRAMS AND POINTS TOWARD A PREECLAMPSIA GENE CLUSTER 10.1016/j.placenta.2015.07.207
2015 Zhang,S, Barker,P, Botting,K, Roberts,C, McMillan,C, McMillen,C, Morrison,J, 2015, RESTRICTION OF PLACENTAL GROWTH FROM CONCEPTION IN THE SHEEP RESULTS IN CHANGES IN PLACENTAL STRUCTURE AND GROWTH FACTOR EXPRESSION THAT ARE INDEPENDENT OF WHETHER THE FETUS BECOMES HYPOXAEMIC IN LATE GESTATION
2015 Andraweera,P, Dekker,G, Leemaqz,S, McCowan,L, Roberts,C, 2015, Obesity related FTO gene polymorphism and the risk of adverse pregnancy outcomes, Annual Conference of the International Federation of Placental Associations (IFPA), Brisbane, Australia 10.1016/j.placenta.2015.07.322
2015 Highet,A, Khoda,S, Buckberry,S, Bianco-Miotto,T, Roberts,C, 2015, ANGIOGENESIS-ASSOCIATED PATHWAYS IN TROPHOBLAST PSEUDOVASCULOGENESIS 10.1016/j.placenta.2015.07.287
2015 Bianco-Miotto,, Rodriguez Lopez,, Leemaqz,, Zhuang,Z, McCullough,, Dekker,, Wilkinson,M, Roberts,C, 2015, Predicting Pregnancy Complications from Maternal Buffy Coat DNA at 15 Weeks Gestation, Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB) Annual Scientific Meeting, Adelaide, Australia
2015 Andraweera,P, Highet,A, Heinemann,G, Roberts,C, 2015, The effects of angiogenic growth factors on first trimester trophoblast invasion and proliferation, Annual Conference of the International Federation of Placental Associations (IFPA) 2015, Brisbane, Australia 10.1016/j.placenta.2015.07.251
2015 Verburg,P, Tucker,G, Scheil,W, Erwich,JJ, Roberts,C, Dekker,G, 2015, OPPOSITE TRENDS IN SEASONALITY OF GESTATIONAL DIABETES MELLITUS AND PREGNANCY INDUCED HYPERTENSIVE DISORDERS - A SOUTH AUSTRALIAN POPULATION STUDY.
2015 Verburg,PE, Tucker,G, Scheil,W, Erwich,JJ, Roberts,CT, Dekker,GA, 2015, [213-POS]: Fetal sex and pregnancy outcomes in south Australia - A retrospective population study 1981-2011., Netherlands 10.1016/j.preghy.2014.10.219
2015 Verburg,PE, Tucker,G, Scheil,W, Erwich,JJ, Roberts,CT, Dekker,GA, 2015, [177-POS]: Seasonality of pregnancy induced hypertensive disorders in South Australia - A retrospective population study 2007-2011., Netherlands 10.1016/j.preghy.2014.10.183
2015 Andraweera,P, Dekker,G, Gatford,K, Leemaqz,S, McCowan,L, Jayasekara,R, Dissanayake,V, Roberts,C, 2015, INSR rs2059806 polymorphism and the risk of preeclampsia, Annual Conference of the International Federation of Placental Associations (IFPA) 2015, Brisbane, Australia 10.1016/j.placenta.2015.07.363
2014 Roberts,C, Leemaqz,S, Bianco-Miotto,T, Andraweera,P, Zhou,A, McCowan,L, Dekker,G, 2014, HOW BIG IS BIG ENOUGH? POPULATION DIFFERENCES IN PREGNANCY OUTCOME, International-Federation-of-Placenta-Associations (IFPA)/EPG Meeting, Paris, FRANCE 10.1016/j.placenta.2014.06.008
2014 Myers,JE, Thomas,G, Tuytten,R, Van Herrewege,Y, Ouandji,R, Roberts,CT, Kenny,LC, Simpson,NA, North,RA, Baker,PN et al, 2014, Fetal Sex Differences in Circulating ADAM-12 Levels in Mid Gestation in Women Who Develop Preeclampsia.
2014 Xiang,R, Estrella,CA, Fitzsimmons,CJ, Kruk,ZA, Thomsen,DA, Rutley,DL, Kind,KL, Roberts,CT, Hiendleder,S, 2014, 97 magnitude and specificity of effects of maternal and paternal genomes on the feto-placental unit., Australia 10.1071/rdv27n1ab97
2014 Zhuang,, Rodriguez Lopez,, Chiam,K, Harryanto,H, Ryan,NK, Jindal,S, Kind,KL, Moretta,S, De Blasio,, Gatford, et al, 2014, A high fat diet early in life and prostate cancer risk, The Australian Health and Medical Research Congress, Melbourne, Australia
2013 Leemaqz,S, Dekker,G, McCowan,L, Roberts,C, 2013, A MODEL AT 15 WEEKS GESTATION TO DISCRIMINATE BETWEEN UNCOMPLICATED PREGNANCIES AND THOSE DESTINED TO DEVELOP PREECLAMPSIA, Meeting of the International-Federation-of-Placenta-Associations (IFPA), Whistler, CANADA 10.1016/j.placenta.2013.06.162
2013 McCormack,C, Furness,D, Dekker,G, Roberts,C, 2013, Anti Mullerian hormone (AMH) levels in recurrent miscarriage patients are lower than those in a normal population, and predict pregnancy outcomes, 33rd Annual Meeting/Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine (SMFM), San Francisco, CA
2012 Everard,C, Khashan,A, McCowan,L, Morth,R, Dekker,G, Roberts,C, Kenny,L, 2012, The effect of maternal prenatal stress, anxiety and depression on neonatal biometric measurements, 59th Annual Scientific Meeting 10.1177/1933719112442493
2005 Roberts,C, Moss,T, Button,J, Nitsos,I, Harding,R, Newnham,J, 2005, Placental gene expression is altered by repeated antenatal betamethasone treatment in sheep

Patents

Date Citation
2009 Roberts,C, Owens,P; 2009; Regulation of cytotrophoblast cell differentiation and cell migration
2008 Roberts,C, Owens,P; 2008; Regulation of cytotrophoblast cell differentiation and cell migration
2007 Roberts,C, Owens,P; 2007; Regulation of Cell Differentiation and Cell Migration
2003 Roberts,C, Owens,P; 2003; Regulation of cytotrophoblast cell differentiation and cell migration

Software

Date Citation
2016 Mayne,B, Leemaqz,S, Buckberry,S, rodriguez lopez,CM, roberts,C, bianco-miotto,T, Breen,J; 2016; msgbsR: an R package for analysing methylation sensitive genotyping by sequencing data
Research Grants

(*CT Roberts is first named / sole Chief Investigator)

2011-2012 Role of the renin-angiotensin system vasodepressor pathways in pregnancy NHF grant in aid #1002813 K Denton, C Tikellis, CT Roberts, R Widdop, R Brown $129,000
2011 DNA damage and recurrent pregnancy loss Bonnie Babes Foundation D Furness, CT Roberts, GA Dekker, D McCormack $20,000
2012-2014 *The role of Vitamin D in placentation and pregnancy success NHMRC Project Grant GNT1020754 CT Roberts, PH Anderson, GA Dekker $699,625
2012-2016 *Senior Research Fellowship B NHMRC Senior Research Fellowship GNT1020749 CT Roberts $716,855
2012 Assessment of the placental colonisation of Fusobacterium nucleatum following experimentally induced periodontitis in the mouse and its effect on pre-term birth Australian Dental Research Foundation JE Stamford, P Zilm, CT Roberts, CL Marchant $5,715
2013-2016 Regulation of the placental renin-angiotensin system by microRNAs; implications for pregnancies complicated by placental insufficiency? NHMRC Project Grant GNT1043537 ER Lumbers, CT Roberts, B Morris, F Broughton Pipkin $466,385
2014-2016 *Fetal sex: an important determinant of the placental transcriptome NHMRC Project GNT1059120 CT Roberts, VL Clifton, C Shoubridge, T Bianco-Miotto, SJ Bent $534,021.50
2014 Cytokine profiles in serum and placenta of pregnant mice following experimentally induced periodontitis Australian Dental Research Foundation P Zilm, T Fitzsimmons, CT Roberts $13,760
2014 Investigating the transcriptome of Fusobacterium nucleatum to explain its role in periodontal disease, adverse birth outcomes and systemic health Australian Dental Research Foundation P Zilm, SP Kidd, FT Sumawi, CT Roberts $11,432
2014-2017 *Screening Tests to Predict Poor Outcomes of Pregnancy  (STOP) Study University of Adelaide CT Roberts, GA Dekker $2,000,000
2015 An evaluation of the effect of bacterial contamination on teeth stained with blood in vitro Australian Society of Endodontology P Zilm, CT Roberts, T Fitszimmons $4,543.20
2015  *Lloyd Cox Strategic Research Excellence Award Lloyd Cox O&G Research Fund
University of Adelaide
CT Roberts $50,000
2015 Obesity and Prostate Cancer Risk Waite Research Institute Research Capacity Development Funding T Bianco-Miotto, K Kind, C Rodrigues Lopez, J Breen, CT Roberts, S Buckberry $23,500
2016 Lloyd Cox Strategic Research Excellence Award Lloyd Cox O&G Research Fund
University of Adelaide
CT Roberts $65,000
2016 Genetic and early life determinants of childhood obesity Channel 7 Children’s Research Foundation P Andraweera, CT Roberts, GA Dekker $35,000
2016-2020 EMPOWER: health systems, adversity and child well being NHMRC Centre for Research Excellence APP1099422 J Lynch, M Sawyer, B Mol, CT Roberts, G Dekker, N Stocks, S Schurer, L Gurrin
N Dwyer, K Bowering
$2,497,573
2016   Investigation of the extra-oral migration and virulence determinants of Fusobacterium nucleatum subsp. nucleatum and their role in adverse birth outcomes Australian Dental Research Foundation K Tian, P Zilm, S Kidd, CT Roberts $13,874
2016-2020 Maternal molecular profiles reflect placental function and development across gestation Using Omics to Define Human Placental Development and Function Across Pregnancy NIH oppRFA-HD-16-036 1 R01 HD089685-01 CT Roberts, GA Dekker, T Bianco-Miotto, JM Breen, AK Smith US$ 953,209
2016 Interactions between micronutrients, metabolic health, obesity and pregnancy outcome Faculty of Health Sciences Seed Funding CT Roberts $14,40

 

Industry Sponsored Research
2010-present Prediction of preeclampsia Funds shared across SCOPE Consortium
Alere San Diego USA
  $1,050,000
2010-2011    Prediction of Preeclampsia with proteomics Pronota NV, Ghent, Belgium   $33,000
2011       Prediction of Preeclampsia Mosaiques Diagnostics and Therapeutics GmbH, Hannover, Germany      $15,000
2015 *Validating algorithms that predict risk for pregnancy complications Commercial Accelerator Scheme
Adelaide Research and Innovation Pty Ltd.
CT Roberts, GA Dekker $45,000
2015 *Validating algorithms that predict risk for pregnancy complications Industry Partner Matching Funds for Commercial Accelerator Scheme
Foresight Health, Adelaide
CT Roberts, GA Dekker $45,000
 
Research Grants Pending  
2017-2021 *Combining ‘omics to predict pregnancy complications

NIH NICHD

Global "Omics" Approaches Targeting Adverse Pregnancy and Neonatal Outcomes Utilizing Existing Cohorts (R01) PAR-14-264

CT Roberts, AK Smith, GA Dekker, T Bianco-Miotto, JM Breen, A Rajakumar US$2,764,033
2018-2022 Health in Pregnancy and Beyond: Discovery and Translation APP1136877 NHMRC Senior Research Fellowship CT Roberts $782,370
2018-2020 Interactions between micronutrients, metabolic health, obesity and pregnancy outcome APP1140752 NHMRC Project Grant CT Roberts, GA Dekker, T Bianco-Miotto, AV Perkins, J Grieger  
2018-2020 Understanding the impact of early life adversity on child neurodevelopment 
and psycho-social health
APP1140767 NHMRC Project Grant CT Roberts, N Hodyl, J Lynch, M Sawyer, GA Dekker, T Bianco-Miotto, PH Andraweera  
2018-2021 Maternal health in the 10 years following first pregnancy with and without a  pregnancy complication in a disadvantaged population APP1140760 NHMRC Project Grant CT Roberts, GA Dekker, M Arstall, S Jesudason, PH Andraweera, T Bianco-Miotto, J Grieger  
Equipment Grants    
2012 xCELLigence DP real-time cell analyser  Robinson Foundation Equipment Grant CT Roberts, SA Robertson, JA Owens $40,000
2012 xCELLigence DP real-time cell analyser DVCR Equipment Grant University of Adelaide CT Roberts $40,000
2012 Sanyo oxygen -controlled cell culture incubator Research Centre for Reproductive Health Small Equipment Grant CT Roberts $10,000
2012 DakoLink IHC Solution: Autostainer Link48 + PT Link DVCR Equipment Grant University of Adelaide R Gibson, J Bowen, L Butler, CT Roberts $68,500
         
                                                    
Supervision of Research Staff and Students
Post-doctoral Fellows:

Supervision of Postdoctoral Fellows and ECR mentoring

2014-2018  Dr Prabha Andraweera MBBS (Colombo) PhD
NHMRC Peter Doherty Biomedical Training Fellow awarded 2015
Genetic and environmental risk for pregnancy complications and subsequent metabolic syndrome
2013-2015  Sean O’Leary PhD
NHMRC Grant funded Post-doctoral fellow
Role of Vitamin D in the placenta and pregnancy outcome
2011-2012  Tina Bianco-Miotto PhD
W Bruce Hall Cancer Council Fellow
Epigenetics in cancer and the placenta
2010-2016 Amanda Highet  PhD
NHMRC Biomedical Training Fellow
Molecular control of placental development

I am regularly asked to speak to ECRs at various career development forums including NGED, HDA, the discipline and the university. In addition, I am an ECR mentor for ASMR. I take the task of helping the next generation of researchers get established very seriously. I also emphasise the need for work life balance and therefore supreme efficiency at work with clear goals and monitoring of progress.     

 
Supervision of Research Students:
Ph.D. Students *CT Roberts is principal supervisor [scholarship funding source]
2017 *Michelle Plummer BSc Hons [APA scholarship]
Haemodynamics in 8-10 year old children following in utero exposure to a pregnancy complication
2017- Hassen Mohammed BSc Hons [APA Scholarship]
Immunisation for flu and pertussis in pregnancy
(Primary supervisor is H Marshall)
2016 Julia Dalton RN Midwife
Developing a pregnancy app
(Primary Supervisor is V Clifton)
2016- Amy Garrett BSc Hons [APA Scholarship]
Neurodevelopment in 8-10 year old children following in utero exposure to a pregnancy complication
(Primary supervisor is N Hodyl)
2015-  *Benjamin Mayne B Biotech Hons [APA Scholarship]
Fetal sex and gestational differences in the placental transcriptome
2014 *Rebecca Wilson (B.Sc. M.Sc.) [APA Scholarship]
Vitamin D and control of blood pressure during pregnancy
(co-supervised by T Bianco-Miotto, G Dekker)
2013-2015 *Alison Leviton (B.Sc. Hons; MSc) [APA Scholarship] Withdrew to family reasons
Interaction between Vitamin D and genetic factors in pregnancy outcome
(co-supervised by G Dekker and P Anderson)
2013-2016 Consuelo Estrella BSc MSc [Australian Leadership Award]
Genetic and fetal sex effects in bovine pregnancy
Dean’s commendation
2012-2015 *Sam Buckberry (B.Sc. Hons) [APA and Channel 7 Children’s Research Foundation and Healthy Development Adelaide Top-up Scholarships]
Next Generation sequencing of placentas associated with male versus female bearing pregnancies
(co-supervised by T Bianco-Miotto, S Bent and GA Dekker)

Dean’s commendation
Sam was a finalist in the 2012 and 2013 ANZPRA New Investigator Awards and won the Promega Student Award at the 2014 Lorne Genome Conference.

2012-2015 *Sultana Mahabbat-e Khoda (B.Sc. M.HSc) [International Postgraduate Research Scholarship]
HIF1α: master regulator of placental function
(co-supervised by T Bianco-Miotto, A Highet and G Dekker)
Downgraded to MSc
2010-2015 Graham Wallace (OAM) Failed to complete
Factors associated with cleft lip and palate
(Primary Supervisor T Gruner Southern Cross University)
2010-2014 *Shalem Leemaqz (M Applied Stats) University of Adelaide Scholarship
Statistical methods to predict fertility and pregnancy success
(co-supervised by GA Dekker and S Bent)
2010-2014 *Jessica Laurence (B. Biotech. Hons) [Australian Postgraduate Award and Robinson Institute Top-up Scholarship]
The role of Vitamin D in placentation and pregnancy success
(co-supervised by GA Dekker and DL Furness)
Jess was a finalist in the 2011and 2012 ANZPRA New Investigator Awards
2009-2013  Shane Sykes BSc Hons [NHMRC Grant awarded to CTR and EL funded scholarship]
The renin angiotensin system and adverse pregnancy outcome
(Primary Supervisor ER Lumbers, KG Pringle, T Zakaar University of Newcastle)
Shane was a finalist in the 2011 ANZPRA New Investigator Award

  

Completed Ph.D. Students  *CT Roberts is principal supervisor [scholarship funding source]
2013-2015 *Alison Leviton (B.Sc. Hons; MSc) [APA Scholarship] Withdrew for family reasons
Interaction between Vitamin D and genetic factors in pregnancy outcome
(co-supervised by G Dekker and P Anderson)
2013-2016 Consuelo Estrella BSc MSc [Australian Leadership Award]
Genetic and fetal sex effects in bovine pregnancy
Dean’s commendation
2012-2015 *Sam Buckberry (B.Sc. Hons) [APA and Channel 7 Children’s Research Foundation and Healthy Development Adelaide Top-up Scholarships]
Next Generation sequencing of placentas associated with male versus female bearing pregnancies
(co-supervised by T Bianco-Miotto, S Bent and GA Dekker)

Dean’s commendation
Sam was a finalist in the 2012 and 2013 ANZPRA New Investigator Awards and won the Promega Student Award at the 2014 Lorne Genome Conference.

2012-2015 *Sultana Mahabbat-e Khoda (B.Sc. M.HSc) [International Postgraduate Research Scholarship]
HIF1α: master regulator of placental function
(co-supervised by T Bianco-Miotto, A Highet and G Dekker)
Downgraded to MSc
2010-2015 Graham Wallace (OAM)
Factors associated with cleft lip and palate
(Primary Supervisor T Gruner Southern Cross University)
2010-2015 *Shalem Leemaqz (M Applied Stats) University of Adelaide Scholarship
Statistical methods to predict fertility and pregnancy success
(co-supervised by GA Dekker and S Bent)
2010-2015 *Jessica Laurence (B. Biotech. Hons) [Australian Postgraduate Award and Robinson Institute Top-up Scholarship]
The role of Vitamin D in placentation and pregnancy success
(co-supervised by GA Dekker and DL Furness)
Jess was a finalist in the 2011and 2012 ANZPRA New Investigator Awards
2009-2013 Shane Sykes BSc Hons [NHMRC Grant awarded to CTR and EL funded scholarship]
The renin angiotensin system and adverse pregnancy outcome
(Primary Supervisor ER Lumbers, KG Pringle, T Zakaar University of Newcastle)
Shane was a finalist in the 2011 ANZPRA New Investigator Award

Shane’s thesis was awarded in September 2013.

2008-2012 *Dr Prabha Andraweera M.B.B.S. (Colombo) [Australian Leadership Award, AUSAID]
(co-supervised by GA Dekker)
Prediction of pregnancy complications

Prabha has brought DNA samples from Sri Lankan pregnancy cohorts. Prabha submitted 1 of 86 abstracts selected for oral presentation from over 1256 submitted with 750 accepted for posters at the Society for Maternal and Fetal Medicine in Chicago in February 2010. She was a finalist in the 2010and 2011 ANZPRA New Investigator Award. She received a travel grant to attend the International Society for the Study of Hypertension in Pregnancy (ISSHP) meeting in Melbourne in 2010 and won the Zuspan Award for best oral presentation by a New Investigator at ISSHP.

Prabha’s thesis was submitted in March 2012 and passed in April 2012 without change. She was awarded the Dean of Graduate Studies Letter of Commendation for her work.

2008-2012 *Ang Zhou B. Sc. (Biomed) (Hons) [Adelaide International Scholarship]
(co-supervised by GA Dekker)
The renin angiotensin system in normal and complicated pregnancy

Ang was awarded the Centre for Reproduction and Genomics Best Student Poster award at the Society for Reproductive Biology Annual Scientific meeting in Melbourne in 2008

Ang’s thesis was submitted in July 2012 and passed in September 2012.

  

Honours students
2017 *Brooke Loughhead BSc
The effect of maternal nutrition during pregnancy on offspring neurodevelopment aged 8-10 years
Primary Supervisor
2016 Alastair Ludington BSc Awarded First Class
Developing computational tools for assessing the evolution of genetic variation in Ancient European populations
Co-supervisor
2016 *Michelle Plummer BSc Awarded First Class
The effect of exposure to preeclampsia in utero on haemodynamics in 8-10 year old SCOPE children
Primary supervisor
2016 *Emma McBean MBBS Awarded First Class
Effect of folate acid status and gestation on maternal heamodynamics in the STOP Study
Primary Supervisor
2015-2016 *Alexandra Samantha BSc Awarded First Class
Effect of folic acid on placental villous explant cellular behavior
Primary Supervisor
2015 Zona Goh BSc Awarded Second Class
Renin angiotensin system in murine pregnancy
Co-supervisor
2014 Zimin Zhuang BSc Awarded Second Class
Effect of a high fat diet on epigenetic state in prostate in 2 generations of male offspring
Co-supervisor
2014 *Benjamin Mayne (B. Biotechnology) Awarded First Class
The role of folate and vitamin D in placental development
2013 *Fleur Spronk (B. Health Science) Awarded First Class
Placentation and pregnancy outcome in vitamin D receptor knockout mice
2011-2012 Justine Stamford (B. Dent. Sur.) Awarded First Class
Pregnancy outcomes in mice with induced periodontitis
(Co-supervised with P Zilm who was Principal Supervisor)
2011-2012 Sara Stockham (B. Dent. Sur.) Awarded First Class
The Association between Individual Fusobacterium nucleatum subspecies and Adverse Pregnancy Outcomes

      

    

  

Memberships

Date Role Membership Country
2017 President International Federation of Placenta Associations
2011 - 2014 Treasurer International Federation of Placenta Associations
2004 Board Member International Federation of Placenta Associations
2004 Member Research Centre for Reproductive Health, University of Adelaide
1998 Secretary Australian and New Zealand Placental Research Association
1998 Perinatal Society of Australia and New Zealand
1998 Member International Federation of Placenta Associations
1996 Chair Australian Society for Medical Research
1991 Chair Society for Reproductive Biology

Committee Memberships

Date Role Committee Institution Country
2003 - 2008 Member Women’s and Children’s Hospital Young Investigator Award Committee, 2006 Chair Scientific Judging Committee

Editorial Boards

Date Role Editorial Board Name Country
2012 Member Molecular and Cellular Endocrinology
2008 - 2013 Member Placenta
Position
Senior Research Fellow
Phone
83133118
Campus
North Terrace
Building
Adelaide Health and Medical Sciences Building
Room Number
WS6067
Org Unit
Paediatrics and Reproductive Health

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