Christine Feinle-Bisset

Professor Christine Feinle-Bisset

Prof Res Fellow (E)

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Prof Christine Feinle-Bisset has a PhD in Nutrition and GI Physiology from the University of Stuttgart-Hohenheim (Germany). She joined the University of Adelaide in 2000. She has been an NHMRC-funded Career Development Fellow and, currently, Senior Research Fellow, since 2004, and is a lead investigator in the Centre of Research Excellence in Translating Nutritional Science to Good Health (NHMRC-funded 2007 - 2018). Her research is clinical and relates to the impact of nutrients on appetite, GI motor and hormone function and perception, in health, obesity and functional dyspepsia. It has contributed significantly to current concepts of the role of gastrointestinal mechanisms in the regulation of energy intake in health and obesity, and symptom generation in functional dyspepsia. The overarching aim of her work is to develop novel, nutrient-based treatment approaches for these disorders.

CRE in Translating Nutritional Science To Good Health:
'Gastrointestinal Function and Appetite Regulation' Group

The research that I lead is recognised internationally for elucidating the role of the GI tract, particularly the role of dietary nutrients, in appetite regulation and the generation of dyspeptic symptoms in humans. This research has made major contributions to current understanding of mechanisms underlying highly prevalent disorders (i.e. with substantial health, economic and psychosocial implications), such as obesity and functional dyspepsia (FD), and shaped current concepts of how nutrients interact with GI function in the regulation of appetite (and overeating) on the one hand, and digestive symptoms (associated with a lack of appetite) on the other. Our research has established (i) a key role for GI motor and hormone functions in energy intake regulation in humans, (ii) that very small amounts of specific nutrients (certain fatty acids and amino acids, as well as non-nutritive substances, such as bitter-tasting agents), through their potent GI effects, have major appetite-suppressant and glucoregulatory effects, (iii) adaptive changes in GI function to both high-fat diets and dietary restriction, and (iv) a key role for dietary factors for symptoms in FD. Work continues with (i) and (ii) to develop novel, nutrient-based treatments for obesity and comorbidities, particularly type 2 diabetes, (iii) will lead to novel, dietary weight-loss solutions by targeting key GI functions, (iv) has transformed current treatment approaches to FD, and is reflected in the latest international guidelines for functional GI disorders. 

 

My team

I lead a dynamic, highly productive immediate team of ~12 - 15 members. Current team members include:

Early/mid-career fellows:
Dr Vida Bitarafan
Dr Simon Veedfald
Assoc Prof Shahram Agah

Current PhD students:
Christina McVeay (part-time)
Peyman Rezaie
Javad Anjom Shoae
Maedeh Moradi

Honours/Master students:
Maryam Sayyad

Research officers:
Penelope Fitzgerald
Scott Standfield
Judith Wishart

Biostatistician:
Kylie Lange
 

Examples of current research projects:

Research Project 1

Title: Effects of dietary amino acids on gastric emptying, gut hormone release, blood glucose and energy intake in healthy, normal weight people and people that are overweight or have obesity or type 2 diabetes

Projects available for: Honours / HDR
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce)
Research project start: Semester 1 and 2
Special requirements: N/A

 

Research Project 2

Title: Effects of the fatty acid, lauric acid, as a free fatty acid, triglyceride or part of a mixed medium-chain triglyceride (MCT) oil, on gastric emptying, gut hormone release, blood glucose control, energy expenditure, appetite and energy intake in healthy volunteers and people with obesity and/or type 2 diabetes

Projects available for: Honours / HDR
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce)
Research project start: Semester 1 and 2
Special requirements: N/A

 

Research Project 3

Title: Effects of combining dietary nutrients (e.g. fatty acids and amino acids) on antropyloroduodenal motility, gastric emptying, gut hormone release, blood glucose control and energy intake in health, obesity and type 2 diabetes

Projects available for: Honours / HDR
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce)
Research project start: Semester 1 and 2
Special requirements: N/A

 

Research Project 4

Title: Effects of bitter tastants (e.g. quinine) alone, or in combination with dietary nutrients, on upper gastrointestinal functions, energy intake and blood glucose, in health, obesity and type 2 diabetes

Projects available for: Honours / HDR
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce)
Research project start: Semester 1 and 2
Special requirements: N/A

 

A number of other projects are also available, and ideas for new projects evolve all the time - please contact me any time to discuss.

  • Appointments

    Date Position Institution name
    2011 - ongoing Professor University of Adelaide, Adelaide
    2010 - 2022 NHMRC Senior Research Fellow University of Adelaide, Adelaide
    2008 - 2010 Associate Professor University of Adelaide, Adelaide
    2004 - 2009 NHMRC Career Development Fellow University of Adelaide, Adelaide
    2001 - 2003 Florey Research Fellow Royal Adelaide Hospital, Adelaide
    2000 - 2000 FTT Fricker Research Fellow University of Adelaide, Adelaide
    1995 - 1999 Postdoctoral researcher University Hospital of Zurich, Zurich
  • Language Competencies

    Language Competency
    English Can read, write, speak, understand spoken and peer review
    German Can read, write, speak, understand spoken and peer review
  • Education

    Date Institution name Country Title
    1992 - 1996 University of Hohenheim, Stuttgart Germany PhD
    1991 - 1992 Centre for Human Nutrition, University of Sheffield United Kingdom MMedSci, Human Nutrition
    1985 - 1991 University of Hohenheim, Stuttgart Germany BSci(Honours), Nutritional Sciences
  • Research Interests

COMPETITIVE PROJECT FUNDING (since 2012)
2007 - 2012  NHMRC Centre of Clinical Research Excellence Grant No 453557 ($2,000,000)
Centre of Clinical Research Excellence in nutritional physiology, interventions and outcomes
(Horowitz M, Clifton PM, Wittert GA, Chapman I, Fraser RJ, Rayner CK, Feinle-Bisset C, Jones KL)

2009 - 2012  NHMRC Project Grant No 565311 ($714,000)
Effects of the fatty acid, lauric acid, on energy intake and gut motor and hormonal function in health and obesity
(Feinle-Bisset C, Horowitz M, Clifton PM, Rades T, Jones KL, Rayner CK)

2009 - 2012  NHMRC Project Grant No 565312 ($714,000)
Gastrointestinal function and appetite in obesity – acute and longer-term effects of changes in energy intake
(Feinle-Bisset C, Clifton PM, Horowitz M, Jones KL, Wittert GA)

2010 - 2013  NHMRC Project Grant No 627139 ($753,500)
Upper gastrointestinal function and glycaemic control in diabetes mellitus
(Rayner CK, Horowitz M, Jones KL, Feinle-Bisset C)

2012  Royal Adelaide Hospital/Institute of Medical and Veterinary Sciences Research Committee Clinical Project Grant ($35,000)
Identification and quantification of the fatty acid sensing molecules, CD36, GPR119, GPR120 and GPR40, in the duodenum of lean and obese humans: relationships with BMI and dietary fat intake
(Little TJ, Feinle-Bisset C)

2012  University of Adelaide Discipline of Medicine Equipment Grant ($35,380)
Clinical trials of novel approaches for the prevention and management of chronic diseases
(Feinle-Bisset C, Horowitz M, Wittert GA, Rayner C)

2012 - 2013  Gum Bequest, Royal Adelaide Hospital Endocrine & Metabolic Unit ($40,000)
Chemosensory mechanisms underlying the effects of dietary proteins on the control of gut hormone release – implications for energy intake regulation and blood glucose control
(Feinle-Bisset C)

2013 - 2018  NHMRC Centre of Research Excellence Grant No 1041687 ($2,500,000)
Centre of Research Excellence in Translating Nutritional Science to Good Health
(Horowitz M, Wittert GA, Clifton PM, Rayner CK, Chapman I, Feinle-Bisset C, Jones KL, Noakes M, Chapman M, Nguyen N)

2013  Royal Adelaide Hospital/Institute of Medical and Veterinary Sciences Research Committee Clinical Project Grant ($47,870)
Effects of aromatic and branched-chain amino acids on gastrointestinal motor and hormone functions, energy intake and blood glucose control in healthy humans
(Steinert RE, Feinle-Bisset C)

2014  Diabetes Australia Research Trust General Grant ($60,000)
Regulation of energy intake and glycaemia by dietary nutrients - implications for novel therapeutic approaches to obesity and type 2 diabetes
(Feinle-Bisset C, Steinert R, Horowitz M, Luscombe-Marsh ND)

2014  Royal Adelaide Hospital/Institute of Medical and Veterinary Sciences Research Committee Clinical Project Grant ($49,910)
Utilisation of dietary amino acids and fatty acids to reduce energy intake and improve blood glucose control - A proof-of-concept study in obese subjects with type 2 diabetes
(Feinle-Bisset C, Steinert RE)

2015 - 2018  NHMRC Project Grant No 1078471 ($779,900)
Effects of dietary amino and fatty acids on energy intake and glycaemia - implications for novel approaches to the management of obesity and type 2 diabetes
(Feinle-Bisset C, Horowitz M, Clifton PM, Rayner CK)

2016  Royal Adelaide Hospital/Institute of Medical and Veterinary Sciences Research Committee Clinical Project Grant ($49,844)
Does impaired gastrointestinal hormone secretion contribute to disordered appetite and blood glucose control in adolescent anorexia nervosa?
(Feinle-Bisset C, Kohn M)

2016  University of Adelaide School of Medicine Equipment Grant ($43,110)
IRIS – Infrared-13C-Stable-Isotope Multi Sampler Analyser - Measurement of the rate of gastric emptying as a major determinant of the regulation of appetite and energy intake, as well as blood glucose levels and blood pressure
(Feinle-Bisset C, Chapman M, Little TJ, Soenen S)

2016  University of Adelaide School of Medicine Equipment Grant ($8,400)
Multiple-channel infusion pump for clinical studies of appetite and glycaemic regulation in health, the elderly, obesity and type 2 diabetes
(Little TJ, Feinle-Bisset C, Chapman I)

2017  University of Adelaide School of Medicine Core Facilities Grant ($67,485)
Appetite, metabolic control and gut function facilities
(Feinle-Bisset C)

2017  University of Adelaide Faculty of Health and Medical Sciences Research Infrastructure Grant ($26,410)
LOGIQ eR7 Ultrasound system to measure 2D and Doppler ultrasound in nutrition research
(Jones KL. Rayner CK, Feinle-Bisset C, Wu T, Soenen S)

2018 - 2022  NHMRC Project Grant No 1143092 ($987,048)
Intermittent fasting versus daily energy restriction for improved human health
(Heilbronn L, Feinle-Bisset C)

2018 - 2022  NHMRC Project Grant No 1147333 ($725,276)
Bitter taste as a mediator of food intake and postprandial glycaemia in health and type 2 diabetes
(Wu T, Rayner C, Jones K, Young R, Feinle-Bisset C)

2018  University of Adelaide Faculty of Health and Medical Sciences Research Infrastructure Grant ($11,931)
Ussing chamber system - investigations of the physiological function of GI epithelial and endothelial tissue
(Page A, Feinle-Bisset C, Young R, Hughes P)

2019 - 2022  NHMRC Project Grant No 1158296  ($987,048)
A novel nutrient combination with potent appetite-suppressant and glucose-lowering effects
(Feinle-Bisset C, Heilbronn L, Poppitt S, Müllertz A)

2021 - 2022  Diabetes Australia Research Program ($60,000)
Effects of the bitter tastant, quinine, on postprandial glycaemia and energy intake in type 2 diabetes - implications for novel strategies for management
(Feinle-Bisset C, Bitarafan V, Horowitz M, Rades T)

2021  University of Adelaide Faculty of Health and Medical Sciences Research Infrastructure Funding ($58,950)
High-resolution manometry system for the evaluation of gastropyloroduodenal motor function
(Feinle-Bisset C, Kouw I, Chapman I)

2022 - 2023  Diabetes Australia Research Program ($70,000)
Combining calcium and tryptophan to lower postprandial blood glucose and reduce food intake in people with type 2 diabetes
(Feinle-Bisset C, Veedfald S, Kouw I, Jones KL, Horowitz M)

 

FELLOWSHIP FUNDING
1996 - 1999  Postdoctoral Fellowship, Kamillo-Eisner-Stiftung, Switzerland (CHF395,000)
(Feinle C)

2000  FTT Fricker Research Fellowship, University of Adelaide ($53,800)
(Feinle C)

2001 - 2003  Florey Research Fellowship, Royal Adelaide Hospital  ($235,000)
(Feinle-Bisset C)

2004 - 2009  NHMRC Career Development Fellowship No 299074 ($450,000)
(Feinle-Bisset C)

2010 - 2015  NHMRC Senior Research Fellowship No 627002 ($688,000)
(Feinle-Bisset C)

2016 - 2022  NHMRC Senior Research Fellowship No 1103020 ($741,000)
(Feinle-Bisset C)

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2022 Principal Supervisor Effects of dietary nutrients and non-nutritive substances on energy intake and blood glucose in humans. Doctor of Philosophy Doctorate Full Time Mrs Maedeh Moradi
    2018 Principal Supervisor The effects of the bitter substance, quinine, on postprandial blood glucose, energy intake and associated gut functions in health and type 2 diabetes Doctor of Philosophy Doctorate Full Time Mr Peyman Rezaie
    2015 Principal Supervisor Regulation of Energy Intake and Blood Glucose by Dietary Nutrients - Implications of Novel Therapeutic Approaches to Obesity and Type-2 Diabetes Doctor of Philosophy Doctorate Part Time Mrs Christina McVeay
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 - 2022 Principal Supervisor The effects of the amino acid, L-tryptophan, alone or with the fatty acid, lauric acid, on energy intake and postprandial glycaemia in health, obesity and type 2 diabetes Doctor of Philosophy Doctorate Full Time Ms Maryam Hajishafiee
    2017 - 2020 Principal Supervisor Effects of Bitter Substances on Energy Intake and Blood Glucose, and Associated Gastrointestinal Functions, in Healthy Humans Doctor of Philosophy Doctorate Full Time Miss Vida Bitarafan
    2017 - 2021 Principal Supervisor The Effects of Protein on Gastrointestinal Responses, Associated with Energy Intake and Blood Glucose Regulation – a Management Strategy for Obesity and Type 2 Diabetes Doctor of Philosophy Doctorate Full Time Ms Rachel Anne Elovaris
    2016 - 2020 Co-Supervisor The nutrient-sensing mechanisms of the mouse stomach and the ghrelin cell in health and obesity Doctor of Philosophy Doctorate Full Time Miss Maria Nunez
    2014 - 2017 Principal Supervisor Regulation of Energy Intake and Blood Glucose by Dietary Nutrients - Implications for Novel Therapeutic Approaches to Obesity and Type 2 Diabetes Doctor of Philosophy Doctorate Full Time Miss Sina Stefanie Ullrich
    2012 - 2017 Co-Supervisor Gastrointestinal Nutrient Sensing in Obesity and type 2 Diabetes: Role in Appetite Regulation and Glycaemic Control Doctor of Philosophy Doctorate Full Time Ms Nada Cvijanovic
    2009 - 2012 Principal Supervisor Oral and Small Intestinal Sensitivity to Fats in Lean and Obese Humans: Implications for Energy Intake Regulation in Obesity Doctor of Philosophy Doctorate Full Time Miss Radhika Virginia Seimon
    2009 - 2016 Principal Supervisor Effects of Protein on Gastrointestinal Function and Appetite Regulation Doctor of Philosophy Doctorate Full Time Dr Amy Hutchison
    2006 - 2009 Principal Supervisor Evaluation of Appetite Regulation in Lean and Obese Individuals Doctor of Philosophy Doctorate Full Time Miss Ixchel Brennan
    2004 - 2008 Principal Supervisor The Role of the Free Fatty Acid, Lauric Acid, in Appetite Regulation and its Potential as an Appetite-Suppressant Doctor of Philosophy Doctorate Full Time Miss Kate Lauren Feltrin
    2003 - 2007 Principal Supervisor Investigations into the Gastrointestinal Factors Involved in the Regulation of Appetite and Energy Intake Doctor of Philosophy Doctorate Full Time Dr Tanya Little
    2003 - 2008 Principal Supervisor Factors Involved in the Regulation of Gastrointestinal Motility, Hormone Release, Symptoms and Energy Intake in Health and Patients with Functional Dyspepsia Doctor of Philosophy Doctorate Full Time Ms Amelia Nicole Pilichiewicz
  • Board Memberships

    Date Role Board name Institution name Country
    2013 - 2016 Director Board of Directors Society for the Study of Ingestive Behavior United States
  • Committee Memberships

    Date Role Committee Institution Country
    2022 - ongoing Chair ANGMA (Australasian Neurogastroenterology and Motility Association) Committee Australasian Neurogastroenterology and Motility Association Australia
    2022 - ongoing Member Rome V Committee Rome Foundation (Guidelines for the diagnosis and treatment of Disorders of Gut Brain Interactions (DGBIs)) United States
    2022 - ongoing Member Nominations Committee Society for the Study of Ingestive Behavior United States
    2020 - 2022 Vice-Chair ANGMA (Australasian Neurogastroenterology and Motility Association) Committee Australasian Neurogastroenterology and Motility Association Australia
    2019 - ongoing Member Executive Committee CRE in Translating Nutritional Sciences to Good Health Australia
    2017 - 2021 Member Local and Scientific Organising Committee International Meeting, Federation of Neurogastroenterology and Motility (FNM), Adelaide, 2021 (postponed from 2020) Australia
    2016 - 2021 Member Program Committee, Annual Scientific Meeting Society for the Study of Ingestive Behavior United States
    2016 - 2017 Chair Local Organising Committee, Annual Meeting 2017 Australasian Neurogastroenterology and Motility Association Australia
    2016 - ongoing Member Adelaide Medical School Research Committee University of Adelaide Australia
    2014 - 2018 Member ANGMA (Australasian Neurogastroenterology and Motility Association) Committee Australasian Neurogastroenterology and Motility Association Australia
    2014 - 2017 Member Gender, Equity and Diversity Committee, Faculty of Health Sciences University of Adelaide Australia
    2013 - 2016 Member Rome IV Committee Rome Foundation (Guidelines for the diagnosis and treatment of Disorders of Gut Brain Interactions (DGBIs)) United States
    2013 - 2018 Member Executive Committee NHMRC CRE in Translating Nutritional Sciences to Good Health Australia
    2012 - 2016 Member Nominations Committee Society for the Study of Ingestive Behavior United States
    2011 - 2015 Member Awards Committee Society for the Study of Ingestive Behavior United States
    2011 - 2015 Member Communication Committee Society for the Study of Ingestive Behavior United States
    2010 - 2016 Chair Space Committee, Discipline of Medicine University of Adelaide Australia
    2010 - 2016 Convener ECR Mentoring Program, School of Medicine University of Adelaide Australia
    2008 - 2011 Member Program Committee, Annual Scientific Meeting Society for the Study of Ingestive Behavior United States
    2008 - 2014 Member Yr 4 MBBS Research Program Assessment Team University of Adelaide Australia
    2008 - 2014 Member Faculty of Health Sciences ECR Fellowship Selection Panel University of Adelaide Australia
    2007 - 2012 Member Executive Committee NHMRC CCRE in Nutritional Physiology, Interventions and Outcomes Australia
  • Offices Held

    Date Office Name Institution Country
    2022 - ongoing President Australasian Neurogastroenterology and Motility Association Australia
    2020 - 2022 President-Elect Australasian Neurogastroenteorlogy and Motility Association Australia
    2007 - 2012 Co-convenor, Honours Program, School of Medicine University of Adelaide Australia
    2004 - 2007 Convenor, Honours Program, Discipline of Medicine University of Adelaide Australia
  • Review, Assessment, Editorial and Advice

    Date Title Type Institution Country
    2020 - ongoing Associate Editor Editorial American Journal of Physiology - Regulatory, Integrative and Comparative Physiology United States
    2020 - 2021 Guest Editor, Special Issue 'Appetite and satiety control - gut mechanisms' Editorial Nutrients Switzerland
    2018 - ongoing Associate Editor Editorial Nutrients Switzerland
    2012 - 2018 Member, Editorial Board Editorial Journal of Gastroenterology and Hepatology United States
    2011 - 2020 Associate Editor Editorial BMC Gastroenterology United Kingdom
    2009 - 2013 Founding member, Editorial Board Editorial Journal of Neurogastroenterology and Motility Korea, Republic of
    2008 - 2014 Member, Editorial Board Editorial World Journal of Gastroenterology China
    2006 - 2009 Member, Editorial Board Editorial Neurogastroenterology and Motility United Kingdom
  • Position: Prof Res Fellow (E)
  • Phone: 83136053
  • Email: christine.feinle@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 5
  • Org Unit: Medical Specialties

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