Carmela Ricciardelli

Dr Carmela Ricciardelli

Research Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


My postdoctoral studies were undertaken in the Department of Surgery, Flinders Medical Centre, South Australia and Dame Roma Mitchell Cancer Research Laboratories, Hanson Institute, South Australia (1996-2003) and I joined the Discipline of Obstetrics and Gynecology, University of Adelaide in 2005. I have received highly competitive fellowships in the Faculty of Health Sciences, University of Adelaide and Cancer Council SA (2004-2014) which have enabled me to build a Reproductive Cancer research group in the Discipline of Obstetrics and Gynaecology, University of Adelaide. I was recently awarded the inaugural Lin Huddleston Ovarian Cancer Research Fellowship,Cancer Council SA (2016-2020).

Dr Ricciardelli a cancer cell biologist; joined the Discipline of Obstetrics and Gynaecology in April 2005. She was awarded her Ph D in 1996 (Flinders University) and has undertaken postdoctoral studies in the Department of Surgery, Flinders Medical Centre, South Australia (1996-2001) and Dame Roma Mitchell Cancer Research Laboratories, Hanson Institute, South Australia (2002-2005). In 2005 Dr Ricciardelli was awarded a Tall Poppy Award for outstanding achievement in the field of biomedical and clinical science. In 2007 she was the recipient of the highly competitive Hilda Farmer Fellowship in Faculty of Health Sciences, University of Adelaide which has enabled her to build a Reproductive cancer research group in the Discipline of O&G, University of Adelaide. In 2012 Dr Ricciardelli was awarded a senior fellowship funded by SAHMRI and Cancer Council SA. In 2015 Dr Ricciardelli was awarded the Lin Huddleston Ovarian Cancer Fellowship funded by  Cancer Council SA & Adelaide Medical School, University of Adelaide

Dr Ricciardelli's research program has focused on hormone-regulated proteins and prognostic markers in breast and prostate cancer. Using a novel approach in her postdoctoral studies by examining the non-cancer stromal cells which surround the cancer cells, Dr Ricciardelli was the first researcher to identify that the expression of the extracellular matrix protein, versican correlated with cancer spread in prostate and breast cancer. This was an exciting and unique discovery that has lead to versican expression being examined in many different cancer types. Versican is a molecule known to regulate cellular movement at critical periods in the developing embryo, and control the movement of normal smooth muscle cells, nerves and fibroblasts. Dr Ricciardelli's recent studies suggest that cancer cells can utilize stromally derived versican to aid their movement.

Dr Ricciardelli current research focuses on further understanding the cross-talk between breast and ovarian cancer cells and the tumour microevironment.The Reproductive Cancer Group seeks to understand the mechanisms involved in ovarian cancer spread, resistance to chemotherapy and the identification of novel biomarkers for early detection.

Project 1
Title: Extracellular vesicles: Identification of novel biomarkers and therapeutic targets for serous ovarian cancer

Description: Extracellular versicles (EVs) are nano-sized membrane-bound particles produced by virtually all cells in the body. They are found in all bodily fluids including the blood of ovarian cancer patients. EVs provide a major route of communication between different cell types throughout the body as they contain DNA, protein, RNA and lipid cargo characteristic of their cells of origin, which can be transferred to distant cells and affect their function. Extracellualr vesicles (EVs) are found in increasing numbers in the blood circulation under certain conditions, e.g. during normal pregnancy, and in cancer. The RNA and protein content of EVs have been characterised in studies of various commercially available cancer cell lines, including ovarian cancer cells; but few studies to date have focussed on ovarian cancer patient blood samples. This study will examine the proteomic profile in EVs isolated from patients with diagnosed late stage serous ovarian cancer, compared to benign serous cystadenomas and healthy controls. Candidate proteins that are differentially expressed will be validated and further characterized in ovarian cancer patient cohorts and using functional assays (adhesion, migration and invasion assays).

Location: Adelaide Health and Medical Science Building , North Terrace

Research project start: Semester 1 & 2

 

Project 2
Title: Novel mechanisms of acquired chemotherapy resistance in serous ovarian cancer

Ovarian cancer is the most lethal gynaecological cancer and ranks as the fifth most common cause of cancer-related death in women in the Western world. Each year over 1,500 women are diagnosed with ovarian cancer and approximately 1,000 women die from this disease in Australia. The standard treatment for advanced ovarian cancer is surgery followed by chemotherapy. Although patients initially respond to this treatment, most patients relapse and develop resistance to chemotherapy and eventually die from the disease. Development of chemoresistance is the main factor contributing to ovarian cancer death. The molecular pathways associated with acquired carboplatin resistant in serous ovarian cancer cells are poorly understood. Links have been demonstrated between chemoresistance and the activation of cancer stem cells, epithelial mesenchymal transition (EMT) and non-coding RNA pathways. A greater understanding of these pathways and mechanisms in a 3D model systems will lead to the identification of novel treatment strategies that can overcome chemotherapy resistance.

Location: Adelaide Health and Medical Science Building , North Terrace

Research project start: Semester 1 & 2

 

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  • Appointments

    Date Position Institution name
    2016 - 2020 Lin Huddleston Ovarian Cancer Fellow University of Adelaide
    2015 - 2015 Lloyd Cox Senior Research Fellow University of Adelaide
    2012 - 2014 Cancer Council South Australia Senior Fellow University of Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2010 Award Most Outstanding Contribution to the Discipline of Obstetrics and Gynaecology
    2008 Award Travel award Cancer Council SA
    2006 Fellowship Hilda Farmer University Fellowship, University of Adelaide
    2005 Award Tall Poppy award, Australian Institute of Political Science for outstanding achievement in the field of biomedical and clinical science
    2003 Fellowship Cancer Research Fellowship, Cancer Council South Australia
    1992 Scholarship Flinders University Scholarship (Postgraduate)
    1986 Award Martin Hansen Award for Dux of Class in B App Science in Medical Laboratory Science (Australian Institute of Medical Laboratory Science)
  • Language Competencies

    Language Competency
    Italian Can read, write, speak and understand spoken
  • Education

    Date Institution name Country Title
    1996 Flinders University Australia Ph D
    1986 University of South Australia Australia B Appl Science
  • Research Interests

Date

Project/ No. Investigators Funding Body Amount
2011 Extracellular matrix-macrophage cross talk in the mammary gland

Ingman WV,

Ricciardelli C,

Sharkey D, 

Russell DL

Robinson Institute

(Collaborative Funding scheme)

$12,000
2011 Infrared fluorescence imager for protein quantitation and cultured cell or whole animal imaging

Russell DL,

Robertson S,

Thompson J,

Rodgers RJ,

Roberts C,

Norman R,

Gilchrist R,

Kennaway D,

Ingman WV, M

ottershead D,

Lane M, 

Robker RL,

Ricciardelli C,

Oehler MK

NHMRC equipment grant $35000
2011-2012 Control of breast cancer density and cancer risk by epithelial-stromal interactions

WV Ingman, 

M Pike,

Ricciardelli C *,

Russell DL *,

Sharkey D *,

Tilley WD*, 

Wu A*

National Breast Cancer Foundation

(Novel concept award)

$199,772
2012

Hyaluronan: a marker of ovarian cancer chemoresistance

Ricciardelli C,

Oehler MK

RAH Clinical Research Fund

$23,000 
2012 High throughput image analysis system for histoquantification of histology images

Ricciardelli C,  

Owens J,

Wittert G,

Roberts CT,

Tilley WD,

Callen D, 

Russell DL, 

Ingman WV, 

Rodgers RJ,

Keefe D,

Findlay D

NHMRC equipment grant (GNT 1038556)

Faculty of Health Sciences

Robinson Institute

$60,000

 

 

$15,000

 

$20,200

2012

Annexin A2: a novel biomarker and therapeutic target for ovarian cancer

Ricciardelli C, 

Oehler MK,

Rodgers RJ

Cancer Council SA/SAHMRI

$93,723

2012-2013 Targeting the cancer peritoneal interaction

Ricciardelli C, 

Oehler MK, 

Hoffmann P

SAHMRI/OCRF $50,000
2013

Hyaluronan: a marker and therapeutic target to overcome ovarian cancer chemoresistance

Ricciardelli C,

Oehler MK,

Heinzelmann-Schwarz V,  

Stephens A *

Cancer Council SA/SAHMRI

$93,891

2013-2014

Targeting the interaction between breast cancer and Toll-like receptors of the immune system to prevent metastasis

Russell DL, 

Ricciardelli C,

Hutchinson M  

SAHMRI $40,000
2013

Targeting the annexin A2 signalling pathway to block ovarian cancer metastasis

Ricciardelli C, 

Oehler MK

Robinson Institute $13,700 
2014 The annexin A2 signalling pathway: Novel biomarkers and therapeutic targets for serous ovarian cancer

Ricciardelli C, 

Oehler MK,

Rodgers RJ

Robinson Research Institute $22,700
2015   Ricciardelli C

Lloyd Cox Fellowship, School of Paediatrics and Reproductive Health

$132,367 

2015 Annexin A2 as a novel diagnostic marker for ovarian cancer

Ricciardelli C,

Oehler MK

Commercial Accelerator Scheme Development grant, Adelaide Research Innovation

$25,000
2016-2020 Tumour-host signalling pathways: Identification of novel ovarian cancer biomarkers and therapeutic targets Ricciardelli C Lin Huddleston Ovarian Cancer Fellowship, Cancer Council SA & School of Medicine, University of Adelaide $750,000

Dr. Ricciardelli has been actively teaching undergraduates in the 3rd Year unit Human reproduction III of the Bachelor of Health Science degree (lecturing and workshops) since 2007.

  • Problem based learning (PBL) tutor in School of Medicine, Flinders University of SA, Endocrinology, 1999
  • Human Reproduction III course, University of Adelaide Lecture “Cancer: Incidence, Development and Treatment” 2007-present
  • Human Reproduction III course, University of Adelaide Workshop “Fertility preservation in patients diagnosed with cancer” 2007-present

 

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 Principal Supervisor Identifying Novel Biomarker and Therapeutic Targets for Chemotherapy-Resistant Serious Ovarian Cancer Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Ms Tannith Marie Noye
    2018 Principal Supervisor Role of Hyaluronan in Ovarian Cancer Signalling Pathways and Chemoresistance Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Zoe Kathleen Price
    2017 Co-Supervisor Investigating the Role of the PIRNA Pathway in Cancer Progression Doctor of Philosophy Doctorate Full Time Miss Eunice Hsiu Yee Lee
    2016 Principal Supervisor Dynamics of the Ovarian Cancer Microenvironment and Chemotherapy Resistance Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Mr Masato Yoshihara
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2011 - 2014 Principal Supervisor Role of Annexin A2 in Ovarian Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Noor Alia Lokman
    2010 - 2016 Co-Supervisor The Role of Estrogen Receptor and the Androgen Receptor in Human Breast Cancer Doctor of Philosophy Doctorate Part Time Mrs Shalini Jindal
    2010 - 2015 Co-Supervisor Utilising Quantitative Immunoproteomics To Reveal Differential Autoantibody Biomarker Panels In Serous Ovarian Cancer Patients Doctor of Philosophy Doctorate Full Time Mrs Karina Martin
    2009 - 2014 Co-Supervisor Adamts1 is a promoter of metastatic cell behaviour in mammary cancer cells Doctor of Philosophy Doctorate Full Time Miss Izza Maria Doreen De Arao Tan
    2009 - 2010 Principal Supervisor The Biological Role of Extracellular Matrix in Ovarian Cancer Metastasis Doctor of Philosophy Doctorate Full Time Miss Miranda Ween
    2009 - 2012 Co-Supervisor The Role of Small Glutamine-Rich Tetratricopeptide Repeat Containing Protein Alpha in Female Reproductive Tissues Doctor of Philosophy Doctorate Full Time Ms Miriam Simone Butler
    2007 - 2010 Co-Supervisor The Role of Epigenetic Modifications in Prostate Tumourigenesis Doctor of Philosophy Doctorate Full Time Ms Karen Huiqin Chiam
    2004 - 2009 Co-Supervisor Functional Analysis of CBFA2T3: A Breast Cancer Tumour Suppressor from Chromosome Band 16q24.3 Doctor of Philosophy Doctorate Full Time Dr Zarqa Saif
    2002 - 2004 Co-Supervisor Versican: regulation, purification, and biological properties of a candidate prognostic indicator for breast cancer Doctor of Philosophy Doctorate Full Time Miss Supaporn Suwiwat
  • Position: Research Fellow
  • Phone: 83138255
  • Email: carmela.ricciardelli@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 5
  • Room: WS5069
  • Org Unit: Paediatrics and Reproductive Health

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