Miranda Ween
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Ween - TITLEHOLDER.
Dr Ween is a Senior Postdoctoral Researcher in the Lung Research Laboratory at the Royal Adelaide Hospital. After completing her PhD in 2010 in cell biology of ovarian cancer, she undertook a postdoctoral position in the Research Centre for Infectious Diseases with a focus on lung pathogenic bacteria and metal biology and biochemistry. In 2015, Dr Ween was invited to join the Lung Research Laboratory in the Department of Thoracic Medicine at the Royal Adelaide Hospital. This gives her the unique position of experience in respiratory medicine, microbiology, biochemistry, and cancer biology.
She has established herself as a world-leader in E-cigarette research with invitations to speak around the globe, and at a parliamentary inquiry as well as many radio, newspaper, and TV interviews. She researches which aspects of E-cigarettes are the most damaging to the lungs for non-smokers as well as looking at what the benefits and/or risks for switching to E-cigarettes may be for smokers.
In addition to her E-cigarette research, Dr Ween investigates how smoking affects inflammation in the lung, and the ability of macrophages to phagocytose lung pathogenic bacteria and the mechanisms into COPD, a lung disease which affects up to 1.5 million Australians.
Dr Ween is an adjunct Lecturer in the School of Medicine at the University of Adelaide
What effects do E-cigarettes have on the lung, and how much safer are they than cigarettes?
Understanding the role macrophages play in COPD and other chronic inflammatory lung diseases
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Appointments
Date Position Institution name 2016 - ongoing National Asthma Council Career Development Fellow Royal Adelaide Hospital 2015 - ongoing Adjunct Lecturer University of adelaide 2015 - ongoing Posdtdoctoral Research Fellow Royal Adelaide Hospital 2010 - 2015 Postodctoral Research Fellow University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Award International Journal of Molecular Science Travel Award - - - 2017 Award Biochemical Society Travel Award - - - 2016 Award Schiccitano Award Department of Thoracic Medicine, Royal Adelaide Hospital - - 2015 Award Lillian Roxon Asthma Australia Travel award National Asthma Council/TSANZ - - 2015 Achievement Finalist for THRF 50th anniversary award The Hospital Research Foundation - - 2013 Award Research Career Development Network Achievement Award School of Molecular Biosciences, University of Adelaide - - 2013 Achievement Executive Deans Order of Merit Faculty of Sciences, University of Adelaide - - 2013 Award Faculty of Sciences Research Excellence Award Finalist Faculty of Sciences, University of Adelaide - - 2013 Award CASS Foundation National Travel Grant - - - 2013 Achievement I’m a Scientist national competition zone winner - - - 2010 Award Robert Seamark Postgraduate Award Department of Obstetrics and Gynaecology, University of Adelaide - - -
Education
Date Institution name Country Title 2010 University of Adelaide Australia Doctorate of Philosophy in Cancer Biology 2006 University of Adelaide Australia Diploma of Languages in French 2005 University of Adelaide Australia Bachelor of Science (Hons) in Cell Biology 2004 University of Adelaide Australia Bachelor Science (Biomedical Science) Majoring in Immunity & Infection and Human Physiology -
Research Interests
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Journals
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Book Chapters
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Conference Papers
Year Citation 2019 Ween, M., Tee, V., Nguyen, P., Jersmann, H., Reynold, P., & Hodge, S. (2019). E-CIGARETTES MAY PLAY A ROLE IN GLUCOCORTICOID RESISTANCE IN ASTHMATICS AS WELL AS DECREASING FLAVOUR AND COIL TEMPERATURE DEPENDENT PHAGOCYTOSIS OF BACTERIA. In RESPIROLOGY Vol. 24 (pp. 46). WILEY. 2019 Ween, M., Hamon, R., Jersmann, H., Reynolds, P. N., & Hodge, S. (2019). What's Your Flavour? Effects of E-cigarette Coil Temperature on Flavour Dependent Reductions of Phagocytosis of Bacteria and Apoptotic Airway Cells. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 199 (pp. 2 pages). Dallas, TX: AMER THORACIC SOC. 2019 Macowan, M. G., Liu, H., Keller, M. D., Ween, M., Hamon, R., Tran, H. B., & Hodge, S. (2019). CHRONIC CIGARETTE SMOKE-INDUCED EMPHYSEMA AND LUNG INFLAMMATION ARE CORRELATED WITH CHANGES IN CT AND MRI THAT ARE ATTENUATED BY LOW-DOSE AZITHROMYCIN IN MICE. In RESPIROLOGY Vol. 24 (pp. 10). WILEY. 2018 Ween, M., Whittall, J., Jones, C., Tran, B. H., & Hodge, S. (2018). THE CD1B LIPID ANTIGEN PRESENTATION PATHWAY IN COPD IS ASSOCIATED WITH OXIDIZED AIRWAY LIPIDS AND SPHINGOLIPID SIGNALING. In RESPIROLOGY Vol. 23 (pp. 111). WILEY. 2018 Ween, M., Whittall, J., Tran, H. B., & Hodge, S. J. (2018). Investigation of Cigarette Smoke Oxidised Lipids on Macrophages. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 197 (pp. 1 page). San Diego, CA: AMER THORACIC SOC. 2018 Hai, T., Roscioli, E., Hamon, R., Ween, M., Hodge, G., Jersmann, H., & Hodge, S. (2018). Differential inflammasome activation in alveoli and bronchioles in response to cigarette smoke or double stranded DNA. In EUROPEAN RESPIRATORY JOURNAL Vol. 52 (pp. 2 pages). Paris, FRANCE: EUROPEAN RESPIRATORY SOC JOURNALS LTD.
2017 Ween, M., Whittall, J., & Hodge, S. (2017). E-Cigarettes Cause Human Bronchial Epithelial Cell Apoptosis And Death As Well As Altered Cytokine Profile. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 195 (pp. 1 page). Washington, DC: AMER THORACIC SOC. 2011 Ricciardelli, C., Lokman, N. A., Ween, M. P., Hoffman, P., & Oehler, M. K. (2011). Role of annexin A2 in ovarian cancer metastasis. In CLINICAL & EXPERIMENTAL METASTASIS Vol. 28 (pp. 215). SPRINGER. -
Conference Items
Year Citation 2020 Macowan, M., Liu, H., Keller, M., Ween, M., Hamon, R., Tran, H., & Hodge, S. (2020). Cigarette smoke-induced emphysema and lung inflammation are attenuated by low-dose azithromycin in BALB/c mice. Poster session presented at the meeting of Respirology. Melbourne: Wiley. 2020 Bastian, N., Thredgold, L., Hodge, S., Gomez, M., Yeo, A., & Ween, M. (2020). COIL METAL COMPOSITION PLAYS A ROLE IN E-CIGARETTE TOXICITY AND MACROPHAGE FUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2020 Ween, M., Bastian, N., & Thredgold, L. (2020). E-cigarette Coil Metal Composition Contributes to Epithelial Cell Toxicity and Macrophage Phagocytic Dysfunction. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. ELECTR NETWORK: AMER THORACIC SOC. 2019 Ween, M. P., Bastian, N. A., Thredgold, L., Reynolds, P. N., & Hodge, S. J. (2019). DEVICE, FLAVOUR, AND COIL TEMPERATURE IN AN E-CIGARETTE ALL CONTRIBUTE TO VIABILITY OF PRIMARY BRONCHIAL EPITHELIAL CELLS AND EFFEROCYTOSIS OF APOPTOTIC BRONCHIAL CELLS BY MACROPHAGES. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2019 Ram, A., Ween, M., Tran, H., Liu, H., & Hodge, S. (2019). DECREASED MACROPHAGE SIRT-1 IN RESPONSE TO CIGARETTE SMOKE. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Tran, H., Roscioli, E., Hamon, R., Ween, M., Hodge, G., Jersmann, H., & Hodge, S. (2018). DIFFERENTIAL NLRP3/AIM2 INFLAMMASOME ACTIVATION IN COPD AND RESPONSE TO CIGARETTE SMOKE. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2017 Tran, H. B., Hamon, R., Truong, T. T., Ween, M., Riscioli, E., Jerssman, H., . . . Hodge, S. (2017). CIGARETTE SMOKE-INDUCED INFLAMMATION IN MACROPHAGES IS INITIATED BY NLRP3/AIM2 INFLAMMASOMES: INVOLVEMENT OF THE SPHINGOSINE-1-PHOSPHATE (S1P) SIGNALLING. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2017 Ween, M., Jones, C., Tran, H., Whittall, J., & Hodge, S. (2017). INVESTIGATION OF THE CD1B LIPID ANTIGEN PRESENTATION PATHWAY IN COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY.
2017 Ween, M. P., Jones, C., Tran, H. B., Whittall, J. J., & Hodge, S. J. (2017). Investigation of the CD1b lipid antigen presentation pathway In pulmonary COPD. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Canberra, Australia: Wiley.
2017 Whittall, J., Ween, M., & Hodge, S. (2017). Innate immune macrophage response to NTHi and azithromycin in COPD. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Canberra, Australia: Wiley.
2017 Ween, M., Whittall, J., & Hodge, S. (2017). E-CIGARETTES CAUSE INCREASED CELL DEATH, APOPTOSIS AND ALTERED CYTOKINE PROFILE OF HUMAN BRONCHIAL EPITHELIAL CELLS. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2016 Tran, H., Rhys, H., Ween, M., Hodge, G., Barnawi, J., Reynolds, P., . . . Hodge, S. (2016). SPNS2 IN THE AIRWAY EPITHELIAL CELLS AND ALVEOLAR MACROPHAGES CONTRIBUTES DIFFERENTLY INTO CIGARETTE-NDUCED DEREGULATED S1P SIGNALING: A TRANSLATION TO THE MECHANISM OF COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Ween, M., Hodge, G., Reynolds, P., & Hodge, S. (2016). The new kid on the block: e-cigarettes can cause damage to airway cells and cause airway macrophage dysfunction. Poster session presented at the meeting of Abstract of the 2016 International Conference of the American Thoracic Society, as published in American Journal of Respiratory and Critical Care Medicine. San Francisco, CA: American Thoracic Society.
WoS22016 Tran, H., Barnawi, J., Ween, M., Hamon, R., Roscioli, E., Hodge, G., . . . Hodge, S. (2016). CHANGED INTRACELLULAR LOCALIZATION OF SPHINGOSINE KINASES BY CIGARETTE SMOKE IN MACROPHAGES MAY CONTRIBUTE TO DEFECTIVE PHAGOCYTIC FUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Ween, M., Hodge, G., Reynolds, P., & Hodge, S. (2016). The new kid on the block: e-cigarettes can cause damage to airway cells and cause airway macrophage dysfunction. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2016 Annual Scientific Meetings, as published in Respirology. Perth, Western Australia: Wiley.
2016 Tran, H., Hamon, R., Ween, M., Hodge, G., Roscioli, E., Barnawi, J., . . . Hodge, S. (2016). DIFFERENTIAL SUBCELLULAR LOCALIZATION AND EXPRESSION OF SPINSTER HOMOLOG 2 (DROSOPHILA) IN AIRWAY EPITHELIAL CELLS AND MACROPHAGES IN RESPONSE TO CIGARETTE SMOKE AND IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE MAY CONTRIBUTE TO MACROPHAGE PHAGOCYTIC DYSFUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Tran, H., Hamon, R., Roscioli, E., Ween, M., Hodge, G., Jersmann, H., . . . Hodge, S. (2016). CIGARETTE SMOKE INDUCED MULTIPLE INFLAMMASOME ACTIVATION AND ANTI-INFLAMMATORY EFFECTS OF S1P AND FTY720 SUGGEST NOVEL TARGETS IN COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2015 Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C., & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Poster session presented at the meeting of Abstract of BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC: BacPath & ASN Events. 2015 Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C., & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. Poster session presented at the meeting of An exchange workshop on antimicrobial resistance. UniSA. 2015 Lokman, N. A., Elder, A. S. F., Ween, M. P., Pyragius, C. E., Hoffmann, P., Ruszkiewicz, A., . . . Ricciardelli, C. (2015). Annexin A2 a potential prognostic marker for serous ovarian cancer promotes ovarian cancer metastasis. Poster session presented at the meeting of CLINICAL & EXPERIMENTAL METASTASIS. SPRINGER.
WoS12015 Ricciardelli, C., Cheruvu, S., Lokman, N. A., Ween, M. P., Tan, I. A., Pyragius, C. E., . . . Oehler, M. K. (2015). Transketolase a protein regulated by ovarian cancer-peritoneal interactions is elevated in omental metastases and regulates serous ovarian cancer proliferation. Poster session presented at the meeting of CLINICAL & EXPERIMENTAL METASTASIS. SPRINGER. 2014 Lokman, N. A., Elder, A. S. F., Ween, M. P., Pyragius, C. E., Hoffmann, P., Ruszkiewicz, A., . . . Oehler, M. K. (2014). ANNEXIN A2 A POTENTIAL PROGNOSTIC MARKER FOR SEROUS OVARIAN CANCER PROMOTES OVARIAN CANCER METATASIS. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. LIPPINCOTT WILLIAMS & WILKINS. 2013 Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C., & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. Poster session presented at the meeting of School of Molecular and Biomedical Sciences 3-Minute Thesis competition. 2011 Pederick, V. G., Ween, M. P., Paton, J. C., & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Poster session presented at the meeting of School of Molecular and Biomedical Science Research Symposium. 2011 Pederick, V. G., Ween, M. P., Paton, J. C., & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Poster session presented at the meeting of Australian Society for Medical Research SA Meeting. 2011 Pederick, V. G., Ween, M. P., Paton, J. C., & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Poster session presented at the meeting of Adelaide Protein Group.
2019 Royal Adelaide Hospital Clinical Project Grant ($50,000)
2018 Rebecca Cooper Foundation project grant ($100,000)
2018 Royal Adelaide Hospital Clinical Project Grant ($50,000)
2018 RAH research committee near miss funding ($50,000)
2018 RAH HSCGB equipment grants ($78,300)
2017 University of Adelaide Faculty of Health and Medical Sciences Development grant ($30,000)
2016 Royal Adelaide Hospital Clinical Project Grant ($50,000)
2016 National Asthma Council/TSANZ Asthma and Airways career development fellowship ($60,000)
2006 – 2009 Practical Demonstrator, School of Molecular and Biomedical Sciences, Adelaide University
2008 – 2010 CBL/PBL Tutor, School of Medicine, Adelaide University
2010 – 2015 School of Molecular Biosciences Centrifuge Trainer
2014 – 2015 Masters of Biotechnology Guest Lecturer
2016 Honours Co-supervisor
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